{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:21:57Z","timestamp":1769084517187,"version":"3.49.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.addr.2007.08.033","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T12:20:48Z","timestamp":1195561248000},"page":"114-123","source":"Crossref","is-referenced-by-count":41,"title":["Beta-cell replacement for insulin-dependent diabetes mellitus"],"prefix":"10.1016","volume":"60","author":[{"given":"Shimon","family":"Efrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2007.08.033_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2007-979040","article-title":"Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones","volume":"29","author":"Sorenson","year":"1997","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.addr.2007.08.033_bib2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2007.08.033_bib4","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.2337\/diabetes.50.2007.S25","article-title":"Regulation of beta-cell mass by hormones and growth factors","volume":"50","author":"Nielsen","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib5","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.2337\/diabetes.48.12.2270","article-title":"Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats","volume":"48","author":"Xu","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib6","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2337\/diabetes.51.5.1443","article-title":"Persistent improvement of type 2 diabetes in the Goto\u2013Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4","volume":"51","author":"Tourrel","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1210\/er.20.6.876","article-title":"The glucagon-like peptides","volume":"20","author":"Kieffer","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.addr.2007.08.033_bib8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1034\/j.1600-0773.2002.910621.x","article-title":"Pharmacological treatment of chronic diabetes by stimulating pancreatic \u03b2-cell regeneration with systemic co-administration of EGF and gastrin","volume":"91","author":"Brand","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.addr.2007.08.033_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00125-003-1287-1","article-title":"Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycemia in C57BL6\/J mice treated with alloxan","volume":"47","author":"Rooman","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib10","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.transproceed.2004.06.069","article-title":"Beta-cell replacement therapy (pancreas and islet transplantation) for treatment of diabetes mellitus: an integrated approach","volume":"36","author":"Sutherland","year":"2004","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.addr.2007.08.033_bib11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib12","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.2337\/diabetes.54.7.2060","article-title":"Five-year follow-up after clinical islet transplantation","volume":"54","author":"Ryan","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib13","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/diabetes.44.12.1458","article-title":"Growth factor\/matrix-induced proliferation of human adult beta-cells","volume":"44","author":"Hayek","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib14","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1210\/jc.82.6.1852","article-title":"Ex vivo expansion of human pancreatic endocrine cells","volume":"82","author":"Beattie","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2007.08.033_bib15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2337\/diabetes.48.5.1013","article-title":"Sustained proliferation of PDX-1+ cells derived from human islets. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro","volume":"48","author":"Beattie","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1677\/joe.0.1660103","article-title":"Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro","volume":"166","author":"Halvorsen","year":"2000","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.addr.2007.08.033_bib17","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2337\/diabetes.45.9.1223","article-title":"Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell\u2013cell contact","volume":"45","author":"Beattie","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib18","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.2337\/diabetes.51.12.3435","article-title":"A novel approach to increase human islet cell mass while preserving beta-cell function","volume":"51","author":"Beattie","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib19","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.1101968","article-title":"Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells","volume":"306","author":"Gershengorn","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.addr.2007.08.033_bib20","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2337\/db06-1545","article-title":"Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing \u03b2-cells","volume":"56","author":"Kayali","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbrc.2005.12.187","article-title":"S. Efrat, Expansion and redifferentiation of adult human pancreatic islet cells","volume":"341","author":"Ouziel-Yahalom","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2007.08.033_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2337\/db06-1165","article-title":"Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells","volume":"56","author":"Chase","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.2337\/db06-1654","article-title":"Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells","volume":"56","author":"Weinberg","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2337\/db06-1446","article-title":"No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro","volume":"56","author":"Atouf","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2007.02.005","article-title":"Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells","volume":"270","author":"Morton","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.addr.2007.08.033_bib26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nm1367","article-title":"Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas","volume":"12","author":"Hao","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00125-004-1606-1","article-title":"In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells","volume":"48","author":"Baeyens","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib28","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2353\/ajpath.2006.050926","article-title":"Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas","volume":"169","author":"Rooman","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2007.08.033_bib29","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1073\/pnas.0507567102","article-title":"Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells","volume":"102","author":"Minami","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib30","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/73128","article-title":"Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells","volume":"6","author":"Ramiya","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib32","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2337\/diabetes.52.8.2007","article-title":"Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture","volume":"52","author":"Gao","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib33","first-page":"521","volume":"vol. 50","author":"Zulewski","year":"2001"},{"key":"10.1016\/j.addr.2007.08.033_bib34","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1634\/stemcells.22-6-1070","article-title":"Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny","volume":"22","author":"Choi","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib35","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1634\/stemcells.2005-0367","article-title":"The defined combination of growth factors controls generation of long-term-replicating islet progenitor-like cells from cultures of adult mouse pancreas","volume":"24","author":"Ta","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib36","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nbt1004","article-title":"Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages","volume":"22","author":"Seaberg","year":"2004","journal-title":"Nat. Biotechnol"},{"key":"10.1016\/j.addr.2007.08.033_bib37","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1073\/pnas.0609490104","article-title":"Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS","volume":"104","author":"Sugiyama","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.addr.2007.08.033_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib39","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib40","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.addr.2007.08.033_bib41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1634\/stemcells.22-3-265","article-title":"Differentiation of human embryonic stem cells into insulin-producing clusters","volume":"22","author":"Segev","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib42","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1073\/pnas.0237371100","article-title":"Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells","volume":"100","author":"Blyszczuk","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib43","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2337\/diabetes.53.4.1030","article-title":"Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells","volume":"53","author":"Miyazaki","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib44","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2337\/diabetes.54.3.720","article-title":"TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro","volume":"54","author":"Dominguez-Bendala","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib45","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1634\/stemcells.2006-0082","article-title":"Differentiation of embryonic stem cells conditionally expressing neurogenin 3","volume":"24","author":"Treff","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.1077838","article-title":"Insulin staining of ES cell progeny from insulin uptake","volume":"299","author":"Rajagopal","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.addr.2007.08.033_bib47","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.2337\/diabetes.53.10.2603","article-title":"Artifactual insulin release from differentiated embryonic stem cells","volume":"53","author":"Hansson","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00125-004-1349-z","article-title":"Insulin expressing cells from differentiated embryonic stem cells are not beta cells","volume":"47","author":"Sipione","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib49","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1242\/dev.01044","article-title":"Development of definitive endoderm from embryonic stem cells in culture","volume":"131","author":"Kubo","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.addr.2007.08.033_bib50","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nbt1163","article-title":"Efficient differentiation of human embryonic stem cells to definitive endoderm","volume":"23","author":"D'Amour","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2007.08.033_bib51","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D'Amour","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2007.08.033_bib52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrm2146","article-title":"Metaplasia and transdifferentiation: from pure biology to the clinic","volume":"8","author":"Slack","year":"2007","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.addr.2007.08.033_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF02255915","article-title":"Transcription factors involved in pancreatic islet development","volume":"7","author":"Huang","year":"2000","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.addr.2007.08.033_bib54","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0959-437X(02)00338-6","article-title":"Signaling and transcriptional control of pancreatic organogenesis","volume":"12","author":"Kim","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.addr.2007.08.033_bib55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00125-004-1368-9","article-title":"Transcriptional networks controlling pancreatic development and beta cell function","volume":"47","author":"Servitja","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib56","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2337\/diabetes.52.7.1732","article-title":"PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells","volume":"52","author":"Noguchi","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib57","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.200108066","article-title":"Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver","volume":"156","author":"Suzuki","year":"2002","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.addr.2007.08.033_bib58","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib59","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and Duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"Ferber","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00125-006-0509-8","article-title":"Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach","volume":"50","author":"Fodor","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(02)01434-3","article-title":"Experimental conversion of liver to pancreas","volume":"13","author":"Horb","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.addr.2007.08.033_bib62","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"Kojima","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib63","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1242\/jcs.115.13.2679","article-title":"Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes","volume":"115","author":"Malhi","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.addr.2007.08.033_bib64","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1053\/gast.2003.50064","article-title":"Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential","volume":"124","author":"Wege","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2007.08.033_bib65","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1073\/pnas.1136854100","article-title":"Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells","volume":"100","author":"Zalzman","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib66","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.2337\/diabetes.54.9.2568","article-title":"Differentiation of human liver-derived insulin-producing cells towards the beta-cell phenotype","volume":"54","author":"Zalzman","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib67","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1073\/pnas.0405277102","article-title":"Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells","volume":"102","author":"Sapir","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib68","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1073\/pnas.0936260100","article-title":"Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells","volume":"100","author":"Suzuki","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib69","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2337\/diabetes.51.5.1398","article-title":"Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin","volume":"51","author":"Kojima","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib70","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.2337\/diabetes.51.8.2505","article-title":"PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells","volume":"51","author":"Yoshida","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.addr.2007.08.033_bib72","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1634\/stemcells.22-4-487","article-title":"Plasticity of bone marrow-derived stem cells","volume":"22","author":"Grove","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib73","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1073\/pnas.0308690100","article-title":"Extrapancreatic insulin-producing cells in multiple organs in diabetes","volume":"101","author":"Kojima","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.addr.2007.08.033_bib74","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI200316502","article-title":"In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion","volume":"111","author":"Ianus","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2007.08.033_bib75","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1007\/s00125-003-1182-9","article-title":"Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells","volume":"46","author":"Choi","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib76","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2337\/diabetes.53.3.616","article-title":"No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo","volume":"53","author":"Lechner","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib77","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2337\/diabetes.55.02.06.db05-1212","article-title":"Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate","volume":"55","author":"Taneera","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib78","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nbt841","article-title":"Bone marrow-derived stem cells initiate pancreatic regeneration","volume":"21","author":"Hess","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2007.08.033_bib79","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1073\/pnas.0608249103","article-title":"Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD\/scid mice","volume":"103","author":"Lee","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.addr.2007.08.033_bib80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1634\/stemcells.2005-0052","article-title":"Formation of pancreatic duct epithelium from bone marrow during neonatal development","volume":"24","author":"Wang","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2337\/diabetes.53.1.91","article-title":"Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury","volume":"53","author":"Mathews","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib82","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2337\/diabetes.53.7.1721","article-title":"In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow","volume":"53","author":"Tang","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib83","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/labinvest.3700074","article-title":"Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes","volume":"84","author":"Oh","year":"2004","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2007.08.033_bib84","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1634\/stemcells.2004-0123","article-title":"Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and\/or microenvironmental manipulation in vitro","volume":"23","author":"Moriscot","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2007.08.033_bib85","unstructured":"O. Karnieli, Y. Izhar-Prato, S. Bulvik, S. Efrat, Generation of insulin- 843 producing cells from human bone marrow mesenchymal stem cells by genetic manipulation, Stem Cells (Jul 5) (in press) [Electronic publication ahead of print]."},{"key":"10.1016\/j.addr.2007.08.033_bib86","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jcp.20897","article-title":"Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells","volume":"211","author":"Li","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.addr.2007.08.033_bib87","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-9255-2-8","article-title":"Mesenchymal stem cells avoid allogeneic rejection","volume":"2","author":"Ryan","year":"2005","journal-title":"J. Inflam. (Lond)"},{"key":"10.1016\/j.addr.2007.08.033_bib88","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1568-9972(02)00033-2","article-title":"Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis","volume":"1","author":"Burt","year":"2002","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.addr.2007.08.033_bib89","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0891-5849(96)02051-5","article-title":"Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues","volume":"20","author":"Lenzen","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib90","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2337\/diabetes.48.6.1223","article-title":"Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction","volume":"48","author":"Rabinovitch","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib91","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/sj.gt.3300922","article-title":"Lentivirus-mediated Bcl-2 expression in beta TC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion","volume":"6","author":"Dupraz","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.addr.2007.08.033_bib92","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.190.8.1135","article-title":"A20 inhibits cytokine-induced apoptosis and nuclear factor kB-dependent gene activation in islets","volume":"190","author":"Grey","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib93","doi-asserted-by":"crossref","first-page":"980","DOI":"10.2337\/diabetes.50.5.980","article-title":"Adenovirus early region 3 (E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in nonobese diabetic (NOD) mice","volume":"50","author":"Efrat","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib94","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s001250051035","article-title":"Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine, and rat pancreatic islets","volume":"41","author":"Benhamou","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib95","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1084\/jem.188.8.1445","article-title":"Pancreatic \u03b2 cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes","volume":"188","author":"Hotta","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.addr.2007.08.033_bib96","doi-asserted-by":"crossref","first-page":"37672","DOI":"10.1074\/jbc.M005150200","article-title":"Dominant negative MyD88 proteins inhibit interleukin-1beta \/interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells","volume":"275","author":"Dupraz","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2007.08.033_bib97","doi-asserted-by":"crossref","first-page":"25862","DOI":"10.1074\/jbc.M103235200","article-title":"SOCS-1 protein prevents Janus Kinase\/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma","volume":"276","author":"Cottet","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2007.08.033_bib98","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.4049\/jimmunol.172.9.5714","article-title":"Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction","volume":"172","author":"Chong","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2007.08.033_bib99","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.2337\/diabetes.52.11.2696","article-title":"Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse","volume":"52","author":"Flodstrom-Tullberg","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib100","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1073\/pnas.92.15.6947","article-title":"Prolonged survival of murine pancreatic islet allografts mediated by adenovirus early region 3 immunoregulatory transgenes","volume":"92","author":"Efrat","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib101","doi-asserted-by":"crossref","first-page":"9808","DOI":"10.1073\/pnas.94.18.9808","article-title":"Expression of adenoviral E3 transgenes in \u03b2 cells prevents autoimmune diabetes","volume":"94","author":"von Herrath","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.addr.2007.08.033_bib102","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2337\/diabetes.52.5.1119","article-title":"Adenovirus early region 3 (E3) anti-apoptotic 10.4\u00a0K, 14.5\u00a0K, and 14.7\u00a0K genes decrease the incidence of autoimmune diabetes in NOD mice","volume":"52","author":"Pierce","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib103","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1089\/hum.1998.9.18-2717","article-title":"Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis","volume":"9","author":"Gallichan","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.addr.2007.08.033_bib104","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1172\/JCI2992","article-title":"Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic TGF-\u03b21","volume":"102","author":"Moritani","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2007.08.033_bib105","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1073\/pnas.251532298","article-title":"Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice","volume":"98","author":"Goudy","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2007.08.033_bib106","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1126\/science.1763328","article-title":"Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets","volume":"254","author":"Lacy","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.addr.2007.08.033_bib107","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI118929","article-title":"Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression","volume":"98","author":"Sun","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2007.08.033_bib108","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00125-001-0729-x","article-title":"Considerations for successful transplantation of encapsulated pancreatic islets","volume":"45","author":"de Vos","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2007.08.033_bib109","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.2337\/diabetes.50.8.1698","article-title":"Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane","volume":"50","author":"Duvivier-Kali","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2007.08.033_bib110","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/S0142-9612(03)00118-2","article-title":"Multifunctional microcapsules for pancreatic islet cell entrapment: design, preparation and in vitro characterization","volume":"24","author":"Luca","year":"2003","journal-title":"Biomaterials"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X07002384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X07002384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T21:09:36Z","timestamp":1684098576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X07002384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":110,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0169409X07002384"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2007.08.033","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}