{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:46:07Z","timestamp":1789721167705,"version":"4.0.1"},"reference-count":121,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.addr.2013.05.011","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T05:01:59Z","timestamp":1370581319000},"page":"2098-2110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Genotoxicity and carcinogenicity risk of carbon nanotubes"],"prefix":"10.1016","volume":"65","author":[{"given":"Shinya","family":"Toyokuni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2013.05.011_bb0005","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev.pharmtox.45.120403.100120","article-title":"The magic bullets and tuberculosis drug targets","volume":"45","author":"Zhang","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1953","key":"10.1016\/j.addr.2013.05.011_bb0010","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/171737a0","article-title":"Molecular structure of nucleic acids","volume":"4356","author":"Watson","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2796.2008.01965.x","article-title":"The molecular mechanisms of the thrombotic complications of atherosclerosis","volume":"263","author":"Libby","year":"2008","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.CIR.102.3.313","article-title":"Common carotid artery intima-media thickness and brain infarction: the Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) case-control study","volume":"102","author":"Touboul","year":"2000","journal-title":"The GENIC Investigators, Circulation"},{"key":"10.1016\/j.addr.2013.05.011_bb0025","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature03095","article-title":"Targeted cancer therapy","volume":"432","author":"Sawyers","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrc3236","article-title":"Antibody therapy of cancer","volume":"12","author":"Scott","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.addr.2013.05.011_bb0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1615\/CritRevOncog.v17.i2.20","article-title":"Src kinase inhibitors: promising cancer therapeutics?","volume":"17","author":"Creedon","year":"2012","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.addr.2013.05.011_bb0040","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0045","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMoa1006448","article-title":"Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer","volume":"363","author":"Kwak","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0050","series-title":"The biology of cancer, Garland Science","author":"Weinberg","year":"2007"},{"key":"10.1016\/j.addr.2013.05.011_bb0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3164\/jcbn.39.3","article-title":"What has been learned from the studies of oxidative stress-induced carcinogenesis: Proposal of the concept of oxygenomics","volume":"39","author":"Toyokuni","year":"2006","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.addr.2013.05.011_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1349-7006.2008.01001.x","article-title":"Role of iron in carcinogenesis: cancer as a ferrotoxic disease","volume":"100","author":"Toyokuni","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0162-0134(92)84069-Y","article-title":"Iron-mediated DNA damage: sensitive detection of DNA strand breakage catalyzed by iron","volume":"47","author":"Toyokuni","year":"1992","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.addr.2013.05.011_bb0070","first-page":"5574","article-title":"Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice","volume":"50","author":"Toyokuni","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0075","first-page":"107","article-title":"Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum- nitrilotriacetate complexes in rats","volume":"76","author":"Ebina","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.addr.2013.05.011_bb0080","first-page":"1867","article-title":"Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate","volume":"47","author":"Li","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0085","doi-asserted-by":"crossref","first-page":"e43403","DOI":"10.1371\/journal.pone.0043403","article-title":"Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer","volume":"7","author":"Akatsuka","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2013.05.011_bb0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/jnci\/djn209","article-title":"Decreased cancer risk after iron reduction in patients with peripheral arterial disease: Results from a randomized trial","volume":"100","author":"Zacharski","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.addr.2013.05.011_bb0095","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10534-010-9361-x","article-title":"Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye view","volume":"23","author":"Chu","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.addr.2013.05.011_bb0100","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3109\/10715762.2011.564170","article-title":"Iron as a target of chemoprevention for longevity in humans","volume":"45","author":"Toyokuni","year":"2011","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0105","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/j.gastro.2004.09.019","article-title":"Iron, hemochromatosis, and hepatocellular carcinoma","volume":"127","author":"Kowdley","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2013.05.011_bb0110","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1067\/mhj.2000.106646","article-title":"Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data","volume":"140","author":"Zacharski","year":"2000","journal-title":"Am. Heart J."},{"key":"10.1016\/j.addr.2013.05.011_bb0115","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cell.2004.09.005","article-title":"At the crossroads of inflammation and cancer","volume":"118","author":"Clevers","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.addr.2013.05.011_bb0120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.addr.2013.05.011_bb0130","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2005-05-2049","article-title":"The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study","volume":"107","author":"Nemeth","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.addr.2013.05.011_bb0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.nutr.26.061505.111303","article-title":"Regulation of iron metabolism by hepcidin","volume":"26","author":"Nemeth","year":"2006","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.addr.2013.05.011_bb0140","first-page":"1","article-title":"Mechanisms of asbestos-induced carcinogenesis","volume":"71","author":"Toyokuni","year":"2009","journal-title":"Nagoya J. Med. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10937404.2011.556051","article-title":"Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases","volume":"14","author":"Huang","year":"2011","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.addr.2013.05.011_bb0150","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/ng.912","article-title":"Germline BAP1 mutations predispose to malignant mesothelioma","volume":"43","author":"Testa","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.addr.2013.05.011_bb0155","series-title":"The Daily Yomiuri","article-title":"79 Kubota workers killed by asbestos over 26years (2005.06.30)","year":"2005"},{"key":"10.1016\/j.addr.2013.05.011_bb0160","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","article-title":"Advances in malignant mesothelioma","volume":"353","author":"Robinson","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0165","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","volume":"366","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2013.05.011_bb0170","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/icvts\/ivs465","article-title":"Multimodal therapy of malignant pleural mesothelioma: is the replacement of radical surgery imminent?","volume":"16","author":"Lindenmann","year":"2012","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"8","key":"10.1016\/j.addr.2013.05.011_bb0175","first-page":"868","article-title":"Editorials this week: Asbestos scandal","volume":"46","author":"Editorial","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0180","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nnano.2008.111","article-title":"Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study","volume":"3","author":"Poland","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2013.05.011_bb0185","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/srep01144","article-title":"Metamorphosis of mesothelial cells wtih active horizontal motility in tissue culture","volume":"3","author":"Nagai","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2013.05.011_bb0190","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1111\/j.1349-7006.2008.00934.x","article-title":"Characteristics and modifying factors of asbestos-induced oxidative DNA damage","volume":"99","author":"Jiang","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0195","doi-asserted-by":"crossref","first-page":"E1330","DOI":"10.1073\/pnas.1110013108","article-title":"Diameter of multi-walled carbon nanotubes is a critical factor in mesothelial injury and subsequent carcinogenesis","volume":"108","author":"Nagai","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2013.05.011_bb0200","first-page":"221","article-title":"Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite","volume":"51","author":"Kubo","year":"2012","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.addr.2013.05.011_bb0205","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1111\/j.1349-7006.2011.02087.x","article-title":"Asbestos surface provides a niche for oxidative modification","volume":"102","author":"Nagai","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0210","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/path.4075","article-title":"Iron overload signature in chrysotile-induced malignant mesothelioma","volume":"228","author":"Jiang","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0215","first-page":"965","article-title":"Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals","volume":"67","author":"Stanton","year":"1981","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.addr.2013.05.011_bb0220","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ajpath.2010.10.039","article-title":"Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma","volume":"178","author":"Jean","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0225","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.855","article-title":"The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma","volume":"43","author":"Bott","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.addr.2013.05.011_bb0230","first-page":"511","article-title":"Codeletion of p15 and p16 in primary malignant mesothelioma","volume":"11","author":"Xio","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.addr.2013.05.011_bb0235","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1038\/sj.onc.1202707","article-title":"High incidence of allelic loss on chromosome 5 and inactivation of p15 INK4B and p16 INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats","volume":"18","author":"Tanaka","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.addr.2013.05.011_bb0240","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0002-9440(10)64860-2","article-title":"Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis","volume":"160","author":"Hiroyasu","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0245","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/labinvest.2009.140","article-title":"Homozygous deletion of CDKN2A\/2B is a hallmark of iron-induced high-grade rat mesothelioma","volume":"90","author":"Hu","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2013.05.011_bb0250","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0165-1218(88)90113-9","article-title":"The genetic toxicity of human carcinogens and its implications","volume":"204","author":"Shelby","year":"1988","journal-title":"Mutat. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0255","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1161(83)90010-9","article-title":"Revised methods for the Salmonella mutagenicity test","volume":"113","author":"Maron","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0260","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/jama.287.9.1132","article-title":"Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution","volume":"287","author":"Pope","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2013.05.011_bb0265","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1349-7006.2003.tb01506.x","article-title":"The implication of background anthracosis in the development and progression of pulmonary adenocarcinoma","volume":"94","author":"Wang","year":"2003","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0270","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1164\/rccm.201106-1011OC","article-title":"Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers","volume":"184","author":"Turner","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0275","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/(SICI)1097-0215(19991222)84:6<609::AID-IJC12>3.0.CO;2-Q","article-title":"DNA methylation and expression of p16(INK4A) gene in pulmonary adenocarcinoma and anthracosis in background lung","volume":"84","author":"Hou","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2013.05.011_bb0280","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/318162a0","article-title":"C60: Buckminsterfullerene","volume":"318","author":"Kroto","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0285","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/354056a0","article-title":"Helical microtubules of graphitic carbon","volume":"354","author":"Iijima","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0290","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1073\/pnas.0509009103","article-title":"Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers","volume":"103","author":"Singh","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2013.05.011_bb0295","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0192623310390705","article-title":"Nanotoxicology \u2014 a pathologist's perspective","volume":"39","author":"Hubbs","year":"2011","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0300","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mrgentox.2011.11.017","article-title":"Single-walled carbon nanotube-induced mitotic disruption","volume":"745","author":"Sargent","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0305","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2131\/jts.33.105","article-title":"Induction of mesothelioma in p53+\/\u2212 mouse by intraperitoneal application of multi-wall carbon nanotube","volume":"33","author":"Takagi","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0310","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2131\/jts.33.381","article-title":"Re: Induction of mesothelioma in p53+\/- mouse by intraperitoneal application of multi-wall carbon nanotube","volume":"33","author":"Ichihara","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0610","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2131\/jts.33.385","article-title":"Re: induction of mesothelioma in p53+\/\u2212 mouse by intraperitoneal application of multi-wall carbon nanotube","volume":"33","author":"Donaldson","year":"2008","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0320","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1111\/j.1349-7006.2012.02318.x","article-title":"Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice","volume":"103","author":"Takagi","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0325","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2131\/jts.34.65","article-title":"Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats","volume":"34","author":"Sakamoto","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0330","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/019262338701500205","article-title":"Spontaneous mesotheliomas in Fischer rats\u2013a histological and electron microscopic study","volume":"15","author":"Tanigawa","year":"1987","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0335","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0092-8674(95)90412-3","article-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","volume":"80","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.addr.2013.05.011_bb0340","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jnci\/90.8.606","article-title":"Multiple primary cancers in families with Li-Fraumeni syndrome","volume":"90","author":"Hisada","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.addr.2013.05.011_bb0345","series-title":"The Genetic Basis of Human Cancer","author":"Vogelstein","year":"1998"},{"key":"10.1016\/j.addr.2013.05.011_bb0350","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/tx200255h","article-title":"Thickness of multiwalled carbon nanotubes affects their lung toxicity","volume":"25","author":"Fenoglio","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.addr.2013.05.011_bb0355","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5858\/133.8.1317","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group","volume":"133","author":"Husain","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0360","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tox.2009.10.017","article-title":"Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes","volume":"269","author":"Porter","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2013.05.011_bb0365","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1743-8977-7-28","article-title":"Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes","volume":"7","author":"Mercer","year":"2010","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.addr.2013.05.011_bb0370","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/cas.12005","article-title":"Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats [In Process Citation]","volume":"103","author":"Xu","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0375","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/toxsci\/kfp100","article-title":"Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat","volume":"110","author":"Muller","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0380","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.ajpath.2011.02.040","article-title":"Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura","volume":"178","author":"Murphy","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0385","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/srep00498","article-title":"Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice","volume":"2","author":"Takanashi","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2013.05.011_bb0390","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/01926230252824851","article-title":"The Tg rasH2 mouse in cancer hazard identification","volume":"30","author":"Morton","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2013.05.011_bb0395","article-title":"Genotoxicity of multi-walled carbon nanotubes in both invitro and in vivo assay systems","author":"Kato","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.addr.2013.05.011_bb0400","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0891-5849(91)90080-M","article-title":"Chemical determination of free radical-induced damage to DNA","volume":"10","author":"Dizdaroglu","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0405","first-page":"365","article-title":"Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model","volume":"76","author":"Toyokuni","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2013.05.011_bb0410","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1349-7006.2012.02326.x","article-title":"Differences and similarities between carbon nanotubes and asbestos fibers during mesothelila carcinogenesis","volume":"103","author":"Nagai","year":"2012","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0415","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2131\/jts.37.177","article-title":"Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice","volume":"37","author":"Yamaguchi","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.addr.2013.05.011_bb0420","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2105\/AJPH.2009.176834","article-title":"Decreases in smoking prevalence in Asian communities served by the Racial and Ethnic Approaches to Community Health (REACH) project","volume":"100","author":"Liao","year":"2010","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.addr.2013.05.011_bb0425","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1001\/jama.2011.334","article-title":"Prevalence of heavy smoking in California and the United States, 1965-2007","volume":"305","author":"Pierce","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2013.05.011_bb0430","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/eurpub\/ckr108","article-title":"Predicting the future prevalence of cigarette smoking in Italy over the next three decades","volume":"22","author":"Carreras","year":"2012","journal-title":"Eur. J. Public Health"},{"key":"10.1016\/j.addr.2013.05.011_bb0435","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrc1190","article-title":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","volume":"3","author":"Hecht","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.addr.2013.05.011_bb0440","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/sim.2602","article-title":"Assessing the combined effect of asbestos exposure and smoking on lung cancer: a Bayesian approach","volume":"26","author":"Wraith","year":"2007","journal-title":"Stat. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0445","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/bjc.2012.75","article-title":"Occupational risk factors have to be considered in the definition of high-risk lung cancer populations","volume":"106","author":"Wild","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.addr.2013.05.011_bb0450","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0891-5849(96)00155-4","article-title":"Role of oxidants\/antioxidants in smoking-induced lung diseases","volume":"21","author":"Rahman","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0455","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0033-0620(03)00079-3","article-title":"Epidemiology of smoking-induced cardiovascular disease","volume":"46","author":"Burns","year":"2003","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.addr.2013.05.011_bb0460","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/MCP.0b013e32834f0e2a","article-title":"Diesel exhaust particles and airway inflammation","volume":"18","author":"Ghio","year":"2012","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0465","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/oemed-2012-101088","article-title":"Diesel engine exhaust classified as a human lung carcinogen. How will this affect occupational exposures?","volume":"69","author":"Scheepers","year":"2012","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0470","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1056\/NEJMra0804752","article-title":"Immunologic aspects of chronic obstructive pulmonary disease","volume":"360","author":"Cosio","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0475","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJM200003233421207","article-title":"Spontaneous pneumothorax","volume":"342","author":"Sahn","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2013.05.011_bb0480","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1289\/ehp.9688","article-title":"Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes","volume":"115","author":"Li","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2013.05.011_bb0485","unstructured":"J. Nakanishi, Risk assessment of Manufactured Nanomaterilas: Carbon Nanotubes (CNT). Final report issued on August 17, 2011. NEDO project (P06041) \"Research and Development of Nanoparticle Chracterization Methods\", 2011."},{"key":"10.1016\/j.addr.2013.05.011_bb0490","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.addr.2013.05.011_bb0495","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/hep.24267","article-title":"The hepcidin circuits act: balancing iron and inflammation","volume":"53","author":"Maliken","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2013.05.011_bb0500","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1080\/15287390701601251","article-title":"Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells","volume":"70","author":"Kisin","year":"2007","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.addr.2013.05.011_bb0505","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.yrtph.2011.07.008","article-title":"Evaluation of the genotoxic potential of single-wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays","volume":"61","author":"Naya","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.addr.2013.05.011_bb0510","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.toxlet.2008.11.024","article-title":"Studies on the in vitro genotoxicity of baytubes, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT)","volume":"186","author":"Wirnitzer","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2013.05.011_bb0515","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.toxlet.2008.11.007","article-title":"Multi-walled carbon nanotubes: lack of mutagenic activity in the bacterial reverse mutation assay","volume":"184","author":"Di Sotto","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2013.05.011_bb0520","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/em.20406","article-title":"Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C(60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells","volume":"49","author":"Jacobsen","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.addr.2013.05.011_bb0525","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1289\/ehp.10924","article-title":"Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappaB, and Akt in normal and malignant human mesothelial cells","volume":"116","author":"Pacurari","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2013.05.011_bb0530","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jat.1385","article-title":"Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition","volume":"29","author":"Yang","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.addr.2013.05.011_bb0535","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.toxlet.2008.11.019","article-title":"Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro","volume":"186","author":"Lindberg","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2013.05.011_bb0540","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/em.20545","article-title":"Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells","volume":"51","author":"Migliore","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.addr.2013.05.011_bb0545","article-title":"Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells","volume":"20","author":"Patlolla","year":"2010","journal-title":"Ethn. Dis."},{"key":"10.1016\/j.addr.2013.05.011_bb0550","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.taap.2012.02.010","article-title":"Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells","volume":"260","author":"Guo","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2013.05.011_bb0555","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3390\/s8010488","article-title":"Cytotoxicity investigation on cultured human blood cells treated with single-walled carbon nanotubes","volume":"8","author":"Zeni","year":"2008","journal-title":"Sensors"},{"key":"10.1016\/j.addr.2013.05.011_bb0560","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1539\/joh.L9150","article-title":"Genotoxicity and cytotoxicity of multi-wall carbon nanotubes in cultured Chinese hamster lung cells in comparison with chrysotile A fibers","volume":"52","author":"Asakura","year":"2010","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.addr.2013.05.011_bb0565","first-page":"349","article-title":"Lack of genotoxicity of carbon nanotubes in a pilot study","volume":"28","author":"Szendi","year":"2008","journal-title":"Anticancer. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0570","doi-asserted-by":"crossref","first-page":"015102","DOI":"10.1088\/0957-4484\/21\/1\/015102","article-title":"Using carbon nanotubes to induce micronuclei and double strand breaks of the DNA in human cells","volume":"21","author":"Cveticanin","year":"2010","journal-title":"Nanotechnology"},{"key":"10.1016\/j.addr.2013.05.011_bb0575","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/carcin\/bgm243","article-title":"Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells","volume":"29","author":"Muller","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.addr.2013.05.011_bb0580","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1021\/nl071303v","article-title":"DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells","volume":"7","author":"Zhu","year":"2007","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2013.05.011_bb0585","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.mrgentox.2011.01.014","article-title":"Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro","volume":"721","author":"Guo","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.addr.2013.05.011_bb0590","doi-asserted-by":"crossref","first-page":"L552","DOI":"10.1152\/ajplung.90287.2008","article-title":"Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL\/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis","volume":"295","author":"Shvedova","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.addr.2013.05.011_bb0595","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-8977-6-2","article-title":"Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE\u2212\/\u2212 mice","volume":"6","author":"Jacobsen","year":"2009","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.addr.2013.05.011_bb0600","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1289\/ehp.11922","article-title":"Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and single-walled carbon nanotubes","volume":"117","author":"Folkmann","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2013.05.011_bb0605","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/tox.20621","article-title":"Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice","volume":"25","author":"Patlolla","year":"2010","journal-title":"Environ. Toxicol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1300149X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1300149X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:34:44Z","timestamp":1759206884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X1300149X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":121,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0169409X1300149X"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2013.05.011","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotoxicity and carcinogenicity risk of carbon nanotubes","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2013.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}