{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:01:22Z","timestamp":1788026482744,"version":"build-2784847793"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.addr.2014.05.007","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T06:30:59Z","timestamp":1400308259000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients"],"prefix":"10.1016","volume":"77","author":[{"given":"Maya","family":"Hites","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Dell'Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Scolletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Silvio","family":"Taccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2014.05.007_bb0005","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/01.TA.0000092378.10660.D1","article-title":"Multiple organ failure in trauma patients","volume":"55","author":"Durham","year":"2003","journal-title":"J. Trauma"},{"key":"10.1016\/j.addr.2014.05.007_bb0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1055\/s-0031-1287866","article-title":"Organ failure in the ICU: cellular alterations","volume":"32","author":"Fullerton","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0015","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/cc7157","article-title":"Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study","volume":"12","author":"Blanco","year":"2008","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0020","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.addr.2014.05.007_bb0025","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1007\/s00134-013-3088-4","article-title":"Clinical implications of antibiotic pharmacokinetic principles in the critically ill","volume":"39","author":"Udy","year":"2013","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0030","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/CCM.0b013e3181961bff","article-title":"Pharmacokinetic issues for antibiotics in the critically ill patient","volume":"37","author":"Roberts","year":"2009","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.addr.2014.05.007_bb0035","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1128\/AAC.00327-13","article-title":"New dosing strategies for an \u2018Old\u2019 antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics of patients with kidney or liver disease","volume":"58","author":"Rao","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/0886022X.2012.684552","article-title":"The pharmacodynamics of vecuronium in chronic renal failure patients: the impact of different priming doses","volume":"34","author":"Tarbeeh","year":"2012","journal-title":"Ren. Fail."},{"key":"10.1016\/j.addr.2014.05.007_bb0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrneph.2011.92","article-title":"Implications of augmented renal clearance in critically ill patients","volume":"7","author":"Udy","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.addr.2014.05.007_bb0050","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/B978-0-7020-4086-3.00027-8","article-title":"Use of antiepileptic drugs in hepatic and renal disease","volume":"119","author":"Asconap\u00e9","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.addr.2014.05.007_bb0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/dmd.107.019869","article-title":"Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia\/reperfusion-induced acute kidney injury","volume":"36","author":"Matsuzaki","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2014.05.007_bb0060","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/jac\/dks257","article-title":"Colistin pharmacokinetics in intensive care unit patients on continuous venovenous haemodiafiltration: an observational study","volume":"67","author":"Markou","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0065","first-page":"12","article-title":"ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO","volume":"28","author":"Shekar","year":"2012","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.addr.2014.05.007_bb0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/MCC.0b013e32835685ad","article-title":"Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation","volume":"18","author":"Jamal","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0075","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/rccm.201201-0059OC","article-title":"Impact of intensive care unit organ failures on mortality during the five years after a critical illness","volume":"186","author":"Lone","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0080","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4065\/81.9.1232","article-title":"Hypoxic liver injury","volume":"81","author":"Ebert","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.addr.2014.05.007_bb0085","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1440-1746.2008.05402.x","article-title":"Etiology and outcome of acute liver failure: retrospective analysis of 50 patients treated at a single center","volume":"23","author":"Hiramatsu","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2014.05.007_bb0090","series-title":"Guide to Drug Dosage in Hepatic Disease: Avery's Drug Treatment. A Guide to the Properties, Choice, Therapeutic Use and Economic Value of Drugs in Disease Management","first-page":"1761","author":"Hebert","year":"1997"},{"key":"10.1016\/j.addr.2014.05.007_bb0095","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/hep.1840140650","article-title":"Therapeutic implications of impaired hepatic oxygen diffusion in chronic liver disease","volume":"14","author":"Morgan","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2014.05.007_bb0100","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hep.1840130428","article-title":"Is glucuronidation truly preserved in patients with liver disease?","volume":"13","author":"Hoyumpa","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2014.05.007_bb0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ccc.2006.02.011","article-title":"Pharmacokinetic changes in critical illness","volume":"22","author":"Boucher","year":"2006","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.addr.2014.05.007_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)06653-0","article-title":"Clearance approaches in pharmacology","volume":"39","author":"Wilkinson","year":"1987","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.addr.2014.05.007_bb0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/bja\/64.5.563","article-title":"Hepatic and extrahepatic disposition of propofol in patients undergoing coronary bypass surgery","volume":"64","author":"Lange","year":"1990","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.addr.2014.05.007_bb0120","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2125.2005.02393.x","article-title":"Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain","volume":"60","author":"Hiraoka","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0125","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/j.1552-4604.1989.tb03327.x","article-title":"Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects","volume":"29","author":"Pentik\u00e4inen","year":"1989","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0130","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/cpt1977214430","article-title":"Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease","volume":"21","author":"Klotz","year":"1977","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0135","first-page":"526","article-title":"Duration of vecuronium-induced neuromuscular block as a predictor of liver allograft dysfunction","volume":"80","author":"Lukin","year":"1995","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.addr.2014.05.007_bb0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1213\/00000539-198704000-00001","article-title":"Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects","volume":"66","author":"Mazoit","year":"1987","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.addr.2014.05.007_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1213\/00000539-198901000-00001","article-title":"Sufentanil pharmacokinetics in patients with cirrhosis","volume":"68","author":"Chauvin","year":"1989","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.addr.2014.05.007_bb0150","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/clpt.2011.133","article-title":"The population pharmaco-kinetics of fentanyl in patients undergoing living-donor liver transplantation","volume":"90","author":"Jin","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0155","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/bja\/81.6.881","article-title":"Metabolism of remifentanil during liver transplantation","volume":"81","author":"Navapurkar","year":"1998","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.addr.2014.05.007_bb0160","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1399-6576.1996.tb04521.x","article-title":"Serum protein binding of propofol in patients with renal failure or hepatic cirrhosis","volume":"40","author":"Costela","year":"1996","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.addr.2014.05.007_bb0165","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2165\/00002018-200528060-00005","article-title":"Dose adjustment in patients with liver disease","volume":"28","author":"Delc\u00f2","year":"2005","journal-title":"Drug Saf."},{"key":"10.1016\/j.addr.2014.05.007_bb0170","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1211\/0022357991772718","article-title":"Distribution of ciprofloxacin into the central nervous system in rats with acute renal or hepatic failure","volume":"51","author":"Naora","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"issue":"Suppl. A","key":"10.1016\/j.addr.2014.05.007_bb0175","first-page":"55","article-title":"Pharmacokinetics of linezolid in patients with liver diseases","volume":"44","author":"Hendershot","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0180","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1345\/aph.1H229","article-title":"Peritoneal fluid penetration of tigecycline","volume":"40","author":"Scheetz","year":"2006","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.addr.2014.05.007_bb0185","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1124\/dmd.31.7.878","article-title":"In vitro metabolism of clindamycin in human liver and intestinal microsomes","volume":"31","author":"Wynalda","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2014.05.007_bb0190","first-page":"216","article-title":"The inter-individual variability of the response to clopidogrel","volume":"98","author":"Gachet","year":"2005","journal-title":"Arch. Mal. Coeur Vaiss."},{"key":"10.1016\/j.addr.2014.05.007_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0749-0690(05)70102-6","article-title":"Oral anticoagulants. Pharmacologic issues for use in the elderly","volume":"17","author":"Hylek","year":"2001","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0200","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3343\/alm.2014.34.2.85","article-title":"Changes in plasma levels of natural anticoagulants in disseminated intravascular coagulation: high prognostic value of antithrombin and protein C in patients with underlying sepsis or severe infection","volume":"34","author":"Choi","year":"2014","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0210","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/cc5949","article-title":"Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units","volume":"11","author":"Bagshaw","year":"2007","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0215","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00134-012-2796-5","article-title":"Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study","volume":"39","author":"Nisula","year":"2013","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000313738","article-title":"Pathophysiology of AKI: injury and normal and abnormal repair","volume":"165","author":"Bonventre","year":"2010","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.addr.2014.05.007_bb0225","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2165\/00003088-199222030-00002","article-title":"Clinical pharmacokinetics of antibiotics in patients with impaired renal function","volume":"22","author":"St Peter","year":"1992","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2014.05.007_bb0230","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc2872","article-title":"Acute renal failure \u2014 definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group","volume":"8","author":"Bellomo","year":"2004","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0235","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00228-009-0678-8","article-title":"Pharmacokinetics and dosage adjustment in patients with renal dysfunction","volume":"65","author":"Verbeeck","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/11318140-000000000-00000","article-title":"Augmented renal clearance: implications for antibacterial dosing in the critically ill","volume":"49","author":"Udy","year":"2010","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2014.05.007_bb0245","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1186\/cc8941","article-title":"Prospective monitoring of cefepime in intensive care unit adult patients","volume":"14","author":"Chapuis","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0250","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0891-5520(03)00057-6","article-title":"Pharmacodynamics and dosing of aminoglycosides","volume":"17","author":"Turnidge","year":"2003","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.addr.2014.05.007_bb0255","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ijantimicag.2011.12.008","article-title":"Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients","volume":"39","author":"Ocampos-Martinez","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.addr.2014.05.007_bb0260","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1186\/cc9091","article-title":"Insufficient \u03b2-lactam concentrations in the early phase of severe sepsis and septic shock","volume":"14","author":"Taccone","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0265","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/cc8945","article-title":"Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock","volume":"14","author":"Taccone","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0270","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1067\/mcp.2000.111934","article-title":"Randomized placebo-controlled trial of activity of the morphine glucuronides","volume":"68","author":"Penson","year":"2000","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0275","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00228-011-1149-6","article-title":"Increased major bleeding risk in patients with kidney dysfunction receiving enoxaparin: a meta-analysis","volume":"68","author":"Hoffmann","year":"2012","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0280","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2165\/00003088-199018050-00004","article-title":"Furosemide (frusemide): a pharmacokinetic\/pharmacodynamic review (part I)","volume":"18","author":"Ponto","year":"1990","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2014.05.007_bb0285","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2165\/00002018-200730110-00001","article-title":"Use of enoxaparin in patients with chronic kidney disease: safety considerations","volume":"30","author":"Brophy","year":"2007","journal-title":"Drug Saf."},{"key":"10.1016\/j.addr.2014.05.007_bb0290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/cc7093","article-title":"Clinical review: drug metabolism and nonrenal clearance in acute kidney injury","volume":"12","author":"Vilay","year":"2008","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0295","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/01.ccx.0000247448.94252.5a","article-title":"The epidemiology of acute renal failure in the world","volume":"12","author":"Uchino","year":"2006","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0300","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1186\/cc12780","article-title":"Continuous renal replacement therapy outcomes in acute kidney injury and end-stage renal disease: a cohort study","volume":"17","author":"Allegretti","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0305","doi-asserted-by":"crossref","first-page":"386","DOI":"10.4103\/0970-9185.98357","article-title":"Renal replacement therapy in ICU","volume":"28","author":"Deepa","year":"2012","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0310","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0272-6386(99)70076-4","article-title":"Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates","volume":"34","author":"Brunet","year":"1999","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.addr.2014.05.007_bb0315","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000092921","article-title":"Elimination of piperacillin and tazobactam by renal replacement therapies with AN69 and polysulfone hemofilters: evaluation of the sieving coefficient","volume":"24","author":"Arzuaga","year":"2006","journal-title":"Blood Purif."},{"key":"10.1016\/j.addr.2014.05.007_bb0320","first-page":"S165","article-title":"Drug dosing adjustments during continuous renal replacement therapies","volume":"66","author":"Golper","year":"1998","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.addr.2014.05.007_bb0325","first-page":"468","article-title":"The effect of adsorption, filter material and point of dilution on antibiotic elimination by haemofiltration an in vitro study of levofloxacin","volume":"24","author":"Choi","year":"2004","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.addr.2014.05.007_bb0330","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1128\/AAC.00858-07","article-title":"Adsorption of amikacin, a significant mechanism of elimination by hemofiltration","author":"Tian","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0345","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1525-1594.2007.00460.x","article-title":"The adsorption of vancomycin by polyacrylonitrile, polyamide, and polysulfone hemofilters","volume":"32","author":"Tian","year":"2008","journal-title":"Artif. Organs"},{"key":"10.1016\/j.addr.2014.05.007_bb0350","series-title":"Critical Care Nephrology","first-page":"1213","article-title":"Principles of solute clearance during continuous renal replacement therapy","author":"Ronco","year":"1998"},{"key":"10.1016\/j.addr.2014.05.007_bb0355","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/clpt.1985.102","article-title":"Multiple-dose ciprofloxacin dose ranging and kinetics","volume":"37","author":"Gonzalez","year":"1985","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0365","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1128\/AAC.45.7.2122-2125.2001","article-title":"Safety and pharmacokinetics of multiple 750-milligram doses of intravenous levofloxacin in healthy volunteers","volume":"45","author":"Chow","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0375","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1034\/j.1399-6576.2001.450802.x","article-title":"Pharmacokinetics and drug dosing adjustments during continuous venovenous hemofiltration or hemodiafiltration in critically ill patients","volume":"45","author":"Bugge","year":"2001","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.addr.2014.05.007_bb0380","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2710.1998.00169.x","article-title":"Use of in vitro models of haemofiltration and haemodiafiltration to estimate dosage regimens for critically ill patients prescribed cefpirome","volume":"23","author":"Phillips","year":"1998","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0385","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1159\/000321488","article-title":"Principles of antibacterial dosing in continuous renal replacement therapy","volume":"30","author":"Choi","year":"2010","journal-title":"Blood Purif."},{"key":"10.1016\/j.addr.2014.05.007_bb0390","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1086\/444500","article-title":"Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy","volume":"41","author":"Trotman","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.addr.2014.05.007_bb0395","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1128\/AAC.45.11.3148-3155.2001","article-title":"Pharmacokinetics of cefepime during continuous renal replacement therapy in critically ill patients","volume":"45","author":"Malone","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0400","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/AAC.44.6.1639-1644.2000","article-title":"Determinants of ceftazidime clearance by continuous venovenous hemofiltration and continuous venovenous hemodialysis","volume":"44","author":"Matzke","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0405","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1128\/AAC.46.5.1557-1560.2002","article-title":"Pharmacokinetics of piperacillin-tazobactam in anuric intensive care patients during continuous venovenous hemodialysis","volume":"46","author":"Mueller","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0410","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/jac\/45.5.701","article-title":"Elimination of meropenem during continuous veno-venous haemofiltration and haemodiafiltration in patients with acute renal failure","volume":"45","author":"Valtonen","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0415","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1097\/CCM.0b013e318241e553","article-title":"Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study","volume":"40","author":"Roberts","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0420","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/cc10257","article-title":"Recommended \u03b2-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy","volume":"15","author":"Seyler","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0425","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/jac\/dkt261","article-title":"A new regimen for continuous infusion of vancomycin during continuous renal replacement therapy","volume":"68","author":"Beumier","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0430","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ijantimicag.2011.01.026","article-title":"Pharmacokinetics of a loading dose of amikacin in septic patients undergoing continuous renal replacement therapy","volume":"37","author":"Taccone","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.addr.2014.05.007_bb0435","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/jac\/48.6.881","article-title":"Elimination of the piperacillin\/tazobactam combination during continuous venovenous haemofiltration and haemodiafiltration in patients with acute renal failure","volume":"48","author":"Valtonen","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0440","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijantimicag.2012.10.018","article-title":"Continuous infusion of vancomycin in septic patients receiving continuous renal replacement therapy","volume":"41","author":"Covajes","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.addr.2014.05.007_bb0445","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/21548331.1984.11702803","article-title":"Extracorporeal oxygenation in neonates","volume":"19","author":"Bartlett","year":"1984","journal-title":"Hosp. Pract."},{"key":"10.1016\/j.addr.2014.05.007_bb0450","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0140-6736(09)61069-2","article-title":"Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial","volume":"374","author":"Peek","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2014.05.007_bb0455","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.jcrc.2013.07.047","article-title":"Extracorporeal membrane oxygenation for severe respiratory failure in adult patients: a systematic review and meta-analysis of current evidence","volume":"28","author":"Zampieri","year":"2013","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0460","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201205-0815OC","article-title":"Extracorporeal membrane oxygenation for pandemic influenza A (H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity-matched analysis","volume":"187","author":"Pham","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0465","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/MAT.0b013e3182904a52","article-title":"Extracorporeal life support organization registry report 2012","volume":"59","author":"Paden","year":"2013","journal-title":"ASAIO J."},{"key":"10.1016\/j.addr.2014.05.007_bb0470","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/cc12681","article-title":"Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study","volume":"17","author":"Aubron","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0475","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1186\/cc12830","article-title":"Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study","volume":"17","author":"Zwiers","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0480","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/MAT.0b013e31819ca3d0","article-title":"Acute renal failure during extracorporeal support in the pediatric cardiac patient","volume":"55","author":"Smith","year":"2009","journal-title":"ASAIO J."},{"key":"10.1016\/j.addr.2014.05.007_bb0485","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/ndt\/gfl326","article-title":"RIFLE classification is predictive of short-term prognosis in critically ill patients with acute renal failure supported by extracorporeal membrane oxygenation","volume":"21","author":"Lin","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.addr.2014.05.007_bb0490","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.hlc.2013.08.009","article-title":"Use of extracorporeal membrane oxygenation in adults","volume":"23","author":"Lafci","year":"2014","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.addr.2014.05.007_bb0495","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.hlc.2008.08.009","article-title":"Review of ECMO (extra corporeal membrane oxygenation) support in critically ill adult patients","volume":"17","author":"Marasco","year":"2008","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.addr.2014.05.007_bb0500","first-page":"171","article-title":"PVC bags considerably reduce availability of diazepam","volume":"44","author":"Mahomed","year":"1998","journal-title":"Cent. Afr. J. Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0505","first-page":"417","article-title":"Factors affecting the availability of diazepam stored in plastic bags and administered through intravenous sets","volume":"40","author":"Kowaluk","year":"1983","journal-title":"Am. J. Hosp. Pharm."},{"key":"10.1016\/j.addr.2014.05.007_bb0510","first-page":"261","article-title":"Interactions between six psychotherapeutic drugs and plastic containers. influence of plastic material and infusion solutions","volume":"31","author":"Airaudo","year":"1993","journal-title":"Int. J. Clin. Pharmacol. Ther. Toxicol."},{"key":"10.1016\/j.addr.2014.05.007_bb0515","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00007691-199308000-00001","article-title":"Preliminary studies of the effects of extracorporeal membrane oxygenator on the disposition of common pediatric drugs","volume":"15","author":"Dagan","year":"1993","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.addr.2014.05.007_bb0520","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1051\/ject\/200739234","article-title":"In vitro drug adsorption and plasma free hemoglobin levels associated with hollow fiber oxygenators in the extracorporeal life support (ECLS) circuit","volume":"39","author":"Preston","year":"2007","journal-title":"J. Extra Corpor. Technol."},{"key":"10.1016\/j.addr.2014.05.007_bb0525","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0011-393X(00)90010-9","article-title":"Effects of neonatal extracorporeal membrane oxygenation circuits on drug disposition","volume":"61","author":"Mulla","year":"2000","journal-title":"Curr. Ther. Res."},{"key":"10.1016\/j.addr.2014.05.007_bb0530","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s00134-010-2041-z","article-title":"Determinants of drug absorption in different ECMO circuits","volume":"36","author":"Wildschut","year":"2010","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0535","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/cc11679","article-title":"Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation","volume":"16","author":"Shekar","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.addr.2014.05.007_bb0540","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/0267659112456894","article-title":"In vitro clearance of dexmedetomidine in extracorporeal membrane oxygenation","volume":"28","author":"Wagner","year":"2013","journal-title":"Perfusion"},{"key":"10.1016\/j.addr.2014.05.007_bb0545","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1191\/0267659105pf827oa","article-title":"Sedative clearance during extracorporeal membrane oxygenation","volume":"20","author":"Bhatt-Mehta","year":"2005","journal-title":"Perfusion"},{"key":"10.1016\/j.addr.2014.05.007_bb0550","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/bja\/82.1.38","article-title":"Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro","volume":"82","author":"Hammaren","year":"1998","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.addr.2014.05.007_bb0555","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1051\/ject\/201042199","article-title":"Modified surface coatings and their effect on drug adsorption within the extracorporeal life support circuit","volume":"42","author":"Preston","year":"2010","journal-title":"J. Extra Corpor. Technol."},{"key":"10.1016\/j.addr.2014.05.007_bb0560","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0022-5223(19)34161-3","article-title":"Plasma fentanyl levels in infants undergoing extracorporeal membrane oxygenation","volume":"105","author":"Leuschen","year":"1993","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.addr.2014.05.007_bb0565","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/1053-0770(93)90158-H","article-title":"Morphine pharmacokinetics in children following cardiac surgery: effects of disease and inotropic support","volume":"7","author":"Dagan","year":"1993","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.addr.2014.05.007_bb0570","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/026765910001500104","article-title":"In vitro evaluation of sedative drug losses during extracorporeal membrane oxygenation","volume":"15","author":"Mulla","year":"2000","journal-title":"Perfusion"},{"key":"10.1016\/j.addr.2014.05.007_bb0575","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0022-3468(92)90547-K","article-title":"Extracellular fluid and total body water changes in neonates undergoing extracorporeal membrane oxygenation","volume":"27","author":"Anderson","year":"1992","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.addr.2014.05.007_bb0580","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2165\/11539220-000000000-00000","article-title":"The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients","volume":"50","author":"Ulldemolins","year":"2011","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2014.05.007_bb0585","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40262-012-0018-5","article-title":"The clinical relevance of plasma protein binding changes","volume":"52","author":"Roberts","year":"2013","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2014.05.007_bb0590","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1378\/chest.11-1396","article-title":"Introduction to drug pharmacokinetics in the critically ill patient","volume":"141","author":"Smith","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.addr.2014.05.007_bb0595","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1007\/s00134-002-1444-x","article-title":"Norepinephrine and vital organ blood flow","volume":"28","author":"Di Giantomasso","year":"2002","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0600","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archsurg.1967.01330170070009","article-title":"The physiologic role of pulsatile and nonpulsatile blood flow. II. Effects on renal function","volume":"95","author":"Many","year":"1967","journal-title":"Arch. Surg."},{"key":"10.1016\/j.addr.2014.05.007_bb0605","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1128\/AAC.01696-09","article-title":"Pharmacokinetics of cefotaxime and desacetylcefotaxime in infants during extracorporeal membrane oxygenation","volume":"54","author":"Ahsman","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0610","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/j.1875-9114.1992.tb02667.x","article-title":"Gentamicin pharmacokinetics in term neonates receiving extracorporeal membrane oxygenation","volume":"12","author":"Bhatt-Mehta","year":"1992","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.addr.2014.05.007_bb0615","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0169-409X(03)00030-9","article-title":"Pharmacokinetics in the newborn","volume":"55","author":"Alcorn","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2014.05.007_bb0620","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/labinvest.2009.119","article-title":"Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine","volume":"90","author":"McILwain","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.addr.2014.05.007_bb0625","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s00134-003-1758-3","article-title":"Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure","volume":"29","author":"Carcillo","year":"2003","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0630","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/00007691-199412000-00004","article-title":"Population pharmacokinetic models: effect of explicit versus assumed constant serum concentration assay error patterns upon parameter values of gentamicin in infants on and off extracorporeal membrane oxygenation","volume":"16","author":"Dodge","year":"1994","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.addr.2014.05.007_bb0635","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1128\/AAC.33.6.817","article-title":"Pharmacokinetics of gentamicin in neonates on extracorporeal membrane oxygenation","volume":"33","author":"Southgate","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0640","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/jac\/dks435","article-title":"Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?","volume":"68","author":"Shekar","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2014.05.007_bb0645","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00134-010-1882-9","article-title":"Oseltamivir carboxylate accumulation in a patient treated by haemodiafiltration and extracorporeal membrane oxygenation","volume":"36","author":"Lemaitre","year":"2010","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0650","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/FTD.0b013e318248672c","article-title":"Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza","volume":"34","author":"Lemaitre","year":"2012","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.addr.2014.05.007_bb0655","first-page":"173","article-title":"The pharmacokinetics of oseltamivir and oseltamivir carboxylate in a critically ill pediatric patient receiving extracorporeal membrane oxygenation and continuous venovenous hemodialysis","volume":"17","author":"Eyler","year":"2012","journal-title":"J. Pediatr. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0660","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","author":"Hypothermia after Cardiac Arrest Study G","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0665","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/01.wco.0000162850.44897.c6","article-title":"Therapeutic hypothermia for hypoxic\u2013ischaemic encephalopathy in the newborn infant","volume":"18","author":"Thoresen","year":"2005","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.addr.2014.05.007_bb0670","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1517\/17425255.2011.574127","article-title":"The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function","volume":"7","author":"Zhou","year":"2011","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.addr.2014.05.007_bb0675","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0022-3565(25)31450-3","article-title":"Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat","volume":"207","author":"Miller","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2014.05.007_bb0680","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/CCM.0b013e31823779f9","article-title":"Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest","volume":"40","author":"Empey","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0685","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/j.1552-4604.1988.tb03229.x","article-title":"Influence of hypo and hyperthermia on disposition of morphine","volume":"28","author":"Bansinath","year":"1988","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2014.05.007_bb0690","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00003246-198510000-00014","article-title":"Influence of hypothermia on the pharmacokinetics of gentamicin and theophylline in piglets","volume":"13","author":"Koren","year":"1985","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.addr.2014.05.007_bb0695","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1124\/dmd.109.031377","article-title":"Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers","volume":"38","author":"Hostler","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2014.05.007_bb0700","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1542\/peds.2007-1987","article-title":"Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy","volume":"121","author":"Roka","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.addr.2014.05.007_bb0705","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000014195","article-title":"Influence of mild hypothermia after hypoxia\u2013ischemia on the pharmacokinetics of gentamicin in newborn pigs","volume":"77","author":"Satas","year":"2000","journal-title":"Biol. Neonate"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1400101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1400101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T23:24:25Z","timestamp":1746228265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X1400101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":136,"alternative-id":["S0169409X1400101X"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2014.05.007","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2014.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}