{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:25:20Z","timestamp":1790112320281,"version":"4.0.1"},"reference-count":207,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL064387"],"award-info":[{"award-number":["R01-HL064387"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01-HL094374"],"award-info":[{"award-number":["P01-HL094374"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-HL100405"],"award-info":[{"award-number":["U01-HL100405"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL117991"],"award-info":[{"award-number":["R01-HL117991"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54-HG007010"],"award-info":[{"award-number":["U54-HG007010"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.addr.2015.05.004","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T03:35:51Z","timestamp":1431574551000},"page":"3-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"special_numbering":"C","title":["Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-1887","authenticated-orcid":false,"given":"Matthew E.","family":"Hartman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-321X","authenticated-orcid":false,"given":"Dao-Fu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Laflamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2015.05.004_bb0005","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1161\/CIRCULATIONAHA.113.001883","article-title":"Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity","volume":"127","author":"Liang","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0010","first-page":"745","article-title":"Comprehensive in vitro proarrhythmia assay, a novel in vitro\/in silico paradigm to detect ventricular proarrhythmic liability: a visionary 21st century initiative","volume":"13","author":"Cavero","year":"2014","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.addr.2015.05.004_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1517\/17460441.2014.867945","article-title":"Can stem-cell-derived models revolutionize drug discovery?","volume":"9","author":"Landgren","year":"2014","journal-title":"Expert Opin. Drug Discovery"},{"key":"10.1016\/j.addr.2015.05.004_bb0020","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature09005","article-title":"Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome","volume":"465","author":"Carvajal-Vergara","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0025","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0030","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1159\/000335753","article-title":"In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells","volume":"28","author":"Fatima","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.addr.2015.05.004_bb0035","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature09747","article-title":"Modelling the long QT syndrome with induced pluripotent stem cells","volume":"471","author":"Itzhaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0050","doi-asserted-by":"crossref","first-page":"7634","DOI":"10.1073\/pnas.78.12.7634","article-title":"Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells","volume":"78","author":"Martin","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0055","first-page":"27","article-title":"The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium","volume":"87","author":"Doetschman","year":"1985","journal-title":"J. Embryol. Exp. Morpholog."},{"key":"10.1016\/j.addr.2015.05.004_bb0060","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.05.004_bb0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF03401776","article-title":"Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers","volume":"6","author":"Itskovitz-Eldor","year":"2000","journal-title":"Mol. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0070","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI200112131","article-title":"Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes","volume":"108","author":"Kehat","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2015.05.004_bb0080","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1073\/pnas.1319738111","article-title":"Derivation of naive human embryonic stem cells","volume":"111","author":"Ware","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0085","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2009.05.015","article-title":"Naive and primed pluripotent states","volume":"4","author":"Nichols","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0090","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.stem.2014.07.002","article-title":"Systematic identification of culture conditions for induction and maintenance of naive human pluripotency","volume":"15","author":"Theunissen","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0095","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature12745","article-title":"Derivation of novel human ground state naive pluripotent stem cells","volume":"504","author":"Gafni","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0100","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1073\/pnas.1004584107","article-title":"Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs","volume":"107","author":"Hanna","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0105","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1089\/scd.2014.0345","article-title":"A view of bivalent epigenetic marks in two human embryonic stem cell lines reveals a different cardiogenic potential","volume":"24","author":"Leschik","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0110","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2008.05.076","article-title":"Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state","volume":"372","author":"Moore","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2015.05.004_bb0115","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0120","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0125","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.05.004_bb0130","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.gpb.2013.09.008","article-title":"Integration-free methods for generating induced pluripotent stem cells","volume":"11","author":"Zhou","year":"2013","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.addr.2015.05.004_bb0135","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0140","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/343657a0","article-title":"Expression pattern of the mouse T gene and its role in mesoderm formation","volume":"343","author":"Wilkinson","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0145","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/CIRCRESAHA.110.227405","article-title":"Myocardial lineage development","volume":"107","author":"Evans","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0150","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1242\/dev.126.21.4691","article-title":"The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo","volume":"126","author":"Kinder","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.addr.2015.05.004_bb0155","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.exphem.2005.06.009","article-title":"Germ layer induction from embryonic stem cells","volume":"33","author":"Gadue","year":"2005","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.addr.2015.05.004_bb0160","doi-asserted-by":"crossref","first-page":"e11134","DOI":"10.1371\/journal.pone.0011134","article-title":"Endogenous Wnt\/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells","volume":"5","author":"Paige","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0165","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1242\/dev.021121","article-title":"Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt\/beta-catenin, Activin\/Nodal and BMP signaling","volume":"135","author":"Sumi","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.addr.2015.05.004_bb0170","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1096\/fj.08-111203","article-title":"Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium","volume":"23","author":"Nakanishi","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2015.05.004_bb0175","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature06894","article-title":"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population","volume":"453","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0180","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000035254.80718.91","article-title":"Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells","volume":"91","author":"Xu","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1432-0436.1991.tb00865.x","article-title":"Visceral-endoderm-like cell lines induce differentiation of murine P19 embryonal carcinoma cells","volume":"46","author":"Mummery","year":"1991","journal-title":"Differentiation"},{"key":"10.1016\/j.addr.2015.05.004_bb0190","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/aja.1002000207","article-title":"Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region","volume":"200","author":"Sugi","year":"1994","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.addr.2015.05.004_bb0195","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/(SICI)1097-0177(199711)210:3<344::AID-AJA13>3.0.CO;2-A","article-title":"Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation","volume":"210","author":"Arai","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.addr.2015.05.004_bb0200","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/9780470151808.sc01f02s2","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes by coculture with endoderm in serum-free medium","author":"Mummery","year":"2007","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0210","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1634\/stemcells.2007-0617","article-title":"Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells","volume":"26","author":"Freund","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0215","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1101\/gad.9.17.2105","article-title":"Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse","volume":"9","author":"Winnier","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0220","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1242\/dev.120.7.1919","article-title":"A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse","volume":"120","author":"Conlon","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.addr.2015.05.004_bb0225","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ydbio.2004.06.004","article-title":"Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior\u2013posterior patterning","volume":"273","author":"Lu","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0230","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nbt1327","article-title":"Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts","volume":"25","author":"Laflamme","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0235","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1001-971","article-title":"Feeder-free growth of undifferentiated human embryonic stem cells","volume":"19","author":"Xu","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0240","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: basement membrane matrix with biological activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0245","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/978-1-61779-201-4_31","article-title":"Methods for the derivation and use of cardiomyocytes from human pluripotent stem cells","volume":"767","author":"Zhu","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0250","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/CIRCRESAHA.112.273144","article-title":"Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method","volume":"111","author":"Zhang","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0255","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1073\/pnas.0702859104","article-title":"Biphasic role for Wnt\/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells","volume":"104","author":"Ueno","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0260","doi-asserted-by":"crossref","first-page":"19812","DOI":"10.1073\/pnas.0605768103","article-title":"Developmental stage-specific biphasic roles of Wnt\/beta-catenin signaling in cardiomyogenesis and hematopoiesis","volume":"103","author":"Naito","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0265","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.devcel.2006.10.002","article-title":"Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages","volume":"11","author":"Kattman","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0270","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.stem.2010.12.008","article-title":"Stage-specific optimization of activin\/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines","volume":"8","author":"Kattman","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0275","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1681\/ASN.2013080831","article-title":"Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers","volume":"25","author":"Lam","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2015.05.004_bb0280","doi-asserted-by":"crossref","first-page":"E1848","DOI":"10.1073\/pnas.1200250109","article-title":"Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling","volume":"109","author":"Lian","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0285","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nprot.2012.150","article-title":"Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt\/beta-catenin signaling under fully defined conditions","volume":"8","author":"Lian","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.addr.2015.05.004_bb0290","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.addr.2015.05.004_bb0295","doi-asserted-by":"crossref","first-page":"051005","DOI":"10.1115\/1.4027145","article-title":"Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts","volume":"136","author":"Rodriguez","year":"2014","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.addr.2015.05.004_bb0300","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/scd.2012.0490","article-title":"Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"22","author":"Lundy","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0305","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/scd.2009.0349","article-title":"Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation","volume":"19","author":"Kim","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0310","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1634\/stemcells.2006-0466","article-title":"Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach","volume":"25","author":"Sartiani","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0315","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.yjmcc.2010.10.029","article-title":"Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy?","volume":"50","author":"Foldes","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0320","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization","volume":"93","author":"He","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0325","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCRESAHA.114.300558","article-title":"Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"114","author":"Yang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0330","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/stem.1331","article-title":"Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes","volume":"31","author":"Robertson","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0335","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1071-9164(98)90240-8","article-title":"New method to evaluate myocyte remodeling from formalin-fixed biopsy and autopsy material","volume":"4","author":"Gerdes","year":"1998","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.addr.2015.05.004_bb0340","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.scr.2010.01.002","article-title":"Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: qualitative effects on electrophysiological responses to drugs","volume":"4","author":"Otsuji","year":"2010","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0345","doi-asserted-by":"crossref","first-page":"H2355","DOI":"10.1152\/ajpheart.00020.2003","article-title":"Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes","volume":"285","author":"Snir","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0350","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1253\/circj.CJ-12-0987","article-title":"Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture","volume":"77","author":"Kamakura","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.addr.2015.05.004_bb0355","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0008-6363(98)00337-X","article-title":"Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart","volume":"42","author":"van der Velden","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0360","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00424-006-0181-3","article-title":"Tension generation and relaxation in single myofibrils from human atrial and ventricular myocardium","volume":"454","author":"Piroddi","year":"2007","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.addr.2015.05.004_bb0365","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvt119","article-title":"Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy","volume":"99","author":"Witjas-Paalberends","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0370","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yjmcc.2014.04.005","article-title":"Tri-iodo-L-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells","volume":"72","author":"Yang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0375","doi-asserted-by":"crossref","first-page":"e37559","DOI":"10.1371\/journal.pone.0037559","article-title":"Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0380","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10544-012-9710-3","article-title":"Sacrificial layer technique for axial force post-assay of immature cardiomyocytes","volume":"15","author":"Taylor","year":"2013","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2015.05.004_bb0385","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1016\/j.biomaterials.2013.04.026","article-title":"Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.004_bb0390","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.CIR.93.1.168","article-title":"Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle","volume":"93","author":"Nabauer","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0395","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0735-1097(98)00330-1","article-title":"Amiodarone reduces transmural heterogeneity of repolarization in the human heart","volume":"32","author":"Drouin","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0400","first-page":"H369","article-title":"Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle","volume":"275","author":"Li","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0405","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.RES.0000062469.83985.9B","article-title":"Cellular basis of abnormal calcium transients of failing human ventricular myocytes","volume":"92","author":"Piacentino","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0410","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yjmcc.2013.03.014","article-title":"Identification and characterization of a transient outward K+ current in human induced pluripotent stem cell-derived cardiomyocytes","volume":"60","author":"Cordeiro","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0415","doi-asserted-by":"crossref","first-page":"E1685","DOI":"10.1073\/pnas.1221022110","article-title":"SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells","volume":"110","author":"Weisbrod","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0420","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.2004.068213","article-title":"Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes","volume":"559","author":"Satin","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0425","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.yjmcc.2012.02.002","article-title":"Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG","volume":"52","author":"Jonsson","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0430","doi-asserted-by":"crossref","first-page":"e45963","DOI":"10.1371\/journal.pone.0045963","article-title":"Human pluripotent stem cell-derived cardiomyocytes: response to TTX and lidocain reveals strong cell to cell variability","volume":"7","author":"Sheng","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0435","doi-asserted-by":"crossref","first-page":"e5407","DOI":"10.1371\/journal.pone.0005407","article-title":"Local control of excitation\u2013contraction coupling in human embryonic stem cell-derived cardiomyocytes","volume":"4","author":"Zhu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0440","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.hrthm.2013.09.061","article-title":"Electronic \u201cexpression\u201d of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells","volume":"10","author":"Bett","year":"2013","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.addr.2015.05.004_bb0445","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fphys.2015.00007","article-title":"Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1","volume":"6","author":"Meijer van Putten","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0450","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/scd.2007.0280","article-title":"In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes","volume":"18","author":"Caspi","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0455","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/cvr\/cvr132","article-title":"Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells","volume":"91","author":"Mehta","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0460","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/CIRCRESAHA.111.262535","article-title":"Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers","volume":"110","author":"Lee","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0465","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pbiomolbio.2007.03.014","article-title":"Influence of anisotropic conduction properties in the propagation of the cardiac action potential","volume":"94","author":"Valderr\u00e1bano","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0470","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/415198a","article-title":"Cardiac excitation\u2013contraction coupling","volume":"415","author":"Bers","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0475","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/01.RES.0000074908.17214.FD","article-title":"T-tubule function in mammalian cardiac myocytes","volume":"92","author":"Brette","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0480","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/304635a0","article-title":"Rapid photochemical inactivation of Ca2+-antagonists shows that Ca2+ entry directly activates contraction in frog heart","volume":"304","author":"Morad","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0485","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1992.sp019398","article-title":"Modulation of contraction by intracellular Na+ via Na(+)\u2013Ca2+ exchange in single shark (Squalus acanthias) ventricular myocytes","volume":"457","author":"Nabauer","year":"1992","journal-title":"J. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0490","doi-asserted-by":"crossref","first-page":"R1781","DOI":"10.1152\/ajpregu.00421.2006","article-title":"Calcium flux in turtle ventricular myocytes","volume":"291","author":"Galli","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0495","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1634\/stemcells.2005-0036","article-title":"Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction","volume":"24","author":"Dolnikov","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0500","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1634\/stemcells.2007-0549","article-title":"Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: insights for driven maturation","volume":"25","author":"Liu","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0505","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1634\/stemcells.2007-0591","article-title":"Calcium handling in human embryonic stem cell-derived cardiomyocytes","volume":"26","author":"Satin","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0510","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ceca.2013.04.004","article-title":"Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects","volume":"54","author":"Zhang","year":"2013","journal-title":"Cell Calcium"},{"key":"10.1016\/j.addr.2015.05.004_bb0515","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1089\/scd.2009.0052","article-title":"Absence of transverse tubules contributes to non-uniform Ca(2+) wavefronts in mouse and human embryonic stem cell-derived cardiomyocytes","volume":"18","author":"Lieu","year":"2009","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0520","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12015-011-9273-3","article-title":"Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes","volume":"7","author":"Lee","year":"2011","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.addr.2015.05.004_bb0525","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s12265-013-9510-z","article-title":"Electrical stimulation promotes maturation of cardiomyocytes derived from human embryonic stem cells","volume":"6","author":"Chan","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0530","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/S0006-3495(04)74271-X","article-title":"The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium","volume":"86","author":"Gyorke","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.addr.2015.05.004_bb0535","doi-asserted-by":"crossref","first-page":"C152","DOI":"10.1152\/ajpcell.00060.2009","article-title":"Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression","volume":"297","author":"Liu","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0540","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.biomaterials.2015.01.067","article-title":"Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro \u2014 correlation between contraction force and electrophysiology","volume":"51","author":"Ribeiro","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.004_bb0545","first-page":"217","article-title":"Oxygenation and metabolism in the developing heart","volume":"8","author":"Fisher","year":"1984","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.addr.2015.05.004_bb0550","first-page":"H1698","article-title":"Glycolysis is predominant source of myocardial ATP production immediately after birth","volume":"261","author":"Lopaschuk","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0555","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1161\/01.RES.56.3.377","article-title":"Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts","volume":"56","author":"Schaper","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052214","article-title":"Analysis of mitochondrial function and localisation during human embryonic stem cell differentiation in vitro","volume":"7","author":"Prowse","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0565","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/978-1-4939-2257-4_37","article-title":"Characterization of mitochondrial populations during stem cell differentiation","volume":"1264","author":"Kerscher","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0570","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1111\/j.1582-4934.2011.01417.x","article-title":"Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure","volume":"15","author":"Gherghiceanu","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0575","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12265-012-9431-2","article-title":"Nuclear reprogramming with c-Myc potentiates glycolytic capacity of derived induced pluripotent stem cells","volume":"6","author":"Folmes","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0580","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.113.302021","article-title":"Unique metabolic features of stem cells, cardiomyocytes, and their progenitors","volume":"114","author":"Gaspar","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0585","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yjmcc.2014.05.009","article-title":"Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation","volume":"74","author":"Hirt","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0590","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1096\/fj.13-228007","article-title":"Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium","volume":"28","author":"Turnbull","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2015.05.004_bb0595","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/CIRCRESAHA.110.223917","article-title":"Neuregulin\/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells","volume":"107","author":"Zhu","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0600","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1089\/scd.2014.0211","article-title":"Neuregulin-1beta induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair","volume":"24","author":"Iglesias-Garcia","year":"2015","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0605","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.RES.74.3.448","article-title":"Electrical stimulation of contractile activity accelerates growth of cultured neonatal cardiocytes","volume":"74","author":"Johnson","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0610","first-page":"H2495","article-title":"Growth effects of electrically stimulated contraction on adult feline cardiocytes in primary culture","volume":"268","author":"Kato","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0615","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0407817101","article-title":"Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds","volume":"101","author":"Radisic","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0620","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nmeth.2524","article-title":"Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"10","author":"Nunes","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.addr.2015.05.004_bb0625","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/scrt507","article-title":"Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"5","author":"Zhu","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2015.05.004_bb0630","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5966\/sctm.2013-0110","article-title":"Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes","volume":"3","author":"Karakikes","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0635","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1089\/scd.2013.0509","article-title":"A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells","volume":"23","author":"Weng","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0640","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrcardio.2011.120","article-title":"The road to biological pacing","volume":"8","author":"Rosen","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0645","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.0000151313.18547.A2","article-title":"Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers","volume":"111","author":"Xue","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0650","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/apha.12061","article-title":"A molecular and genetic outline of cardiac morphogenesis","volume":"207","author":"Rana","year":"2013","journal-title":"Acta Physiol (Oxf.)"},{"key":"10.1016\/j.addr.2015.05.004_bb0655","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1161\/CIRCEP.111.963421","article-title":"Molecular analysis of patterning of conduction tissues in the developing human heart","volume":"4","author":"Sizarov","year":"2011","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0660","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvs120","article-title":"T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells","volume":"94","author":"Bakker","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0665","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0670","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/CIRCRESAHA.116.305913","article-title":"RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells","volume":"116","author":"Vedantham","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0675","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/dvdy.24078","article-title":"Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development","volume":"243","author":"Nelson","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.addr.2015.05.004_bb0680","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCRESAHA.110.218693","article-title":"Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium","volume":"107","author":"Lai","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0685","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0690","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/dbio.1999.9298","article-title":"Chamber-specific cardiac expression of Tbx5 and heart defects in Holt\u2013Oram syndrome","volume":"211","author":"Bruneau","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0695","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/MCB.21.5.1730-1736.2001","article-title":"Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression","volume":"21","author":"Bruneau","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0700","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1006\/dbio.1999.9548","article-title":"Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand","volume":"217","author":"Bruneau","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0705","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.devcel.2013.04.017","article-title":"Atrial identity is determined by a COUP-TFII regulatory network","volume":"25","author":"Wu","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0710","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/01.RES.0000261693.13269.bf","article-title":"CHF1\/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression","volume":"100","author":"Koibuchi","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0715","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/stem.1923","article-title":"Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity","volume":"33","author":"Dorn","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0720","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.stemcr.2014.11.004","article-title":"SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability","volume":"4","author":"Ionta","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.addr.2015.05.004_bb0725","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1073\/pnas.162301699","article-title":"Neuregulin-1 promotes formation of the murine cardiac conduction system","volume":"99","author":"Rentschler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.004_bb0730","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1096\/fj.04-1619fje","article-title":"Endothelin induces differentiation of ANP\u2013EGFP expressing embryonic stem cells towards a pacemaker phenotype","volume":"18","author":"Gassanov","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2015.05.004_bb0735","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1432-0436.2008.00283.x","article-title":"Retinoid acid-induced effects on atrial and pacemaker cell differentiation and expression of cardiac ion channels","volume":"76","author":"Gassanov","year":"2008","journal-title":"Differentiation"},{"key":"10.1016\/j.addr.2015.05.004_bb0740","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/cr.2010.163","article-title":"Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals","volume":"21","author":"Zhang","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0745","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1089\/scd.2011.0254","article-title":"Primitive cardiac cells from human embryonic stem cells","volume":"21","author":"Hudson","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0750","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/stem.1921","article-title":"Isolation and characterization of ESC-derived cardiac Purkinje cells","volume":"33","author":"Maass","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0755","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature10147","article-title":"Heart regeneration","volume":"473","author":"Laflamme","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0760","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature11317","article-title":"Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts","volume":"489","author":"Shiba","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0765","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1074248413520344","article-title":"Electrical integration of human embryonic stem cell-derived cardiomyocytes in a guinea pig chronic infarct model","volume":"19","author":"Shiba","year":"2014","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2015.05.004_bb0770","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","article-title":"Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts","volume":"510","author":"Chong","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0775","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4939-1047-2_20","article-title":"Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts","volume":"1181","author":"Zhu","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb0780","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1529\/biophysj.105.061820","article-title":"Genesis of ectopic waves: role of coupling, automaticity, and heterogeneity","volume":"89","author":"Pumir","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.addr.2015.05.004_bb0785","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1529\/biophysj.107.117630","article-title":"Generation and escape of local waves from the boundary of uncoupled cardiac tissue","volume":"94","author":"Biktashev","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.addr.2015.05.004_bb0790","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/01.CIR.0000027585.05868.67","article-title":"Stem cell-derived cardiomyocytes demonstrate arrhythmic potential","volume":"106","author":"Zhang","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0795","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.jacc.2007.07.054","article-title":"Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts","volume":"50","author":"Caspi","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0800","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.scr.2007.06.001","article-title":"Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction","volume":"1","author":"van Laake","year":"2007","journal-title":"Stem Cell Res."},{"issue":"2002","key":"10.1016\/j.addr.2015.05.004_bb0805","first-page":"288","article-title":"Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats","volume":"92","author":"Min","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0810","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1096\/fj.02-0072com","article-title":"Stem cell differentiation requires a paracrine pathway in the heart","volume":"16","author":"Behfar","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2015.05.004_bb0815","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1096\/fj.06-6769com","article-title":"Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response","volume":"21","author":"Nussbaum","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2015.05.004_bb0820","doi-asserted-by":"crossref","first-page":"I166","DOI":"10.1161\/CIRCULATIONAHA.104.525824","article-title":"Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium","volume":"112","author":"Swijnenburg","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0825","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/CIRCRESAHA.108.175505","article-title":"Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents","volume":"102","author":"van Laake","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0830","doi-asserted-by":"crossref","first-page":"734","DOI":"10.5966\/sctm.2013-0189","article-title":"Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia\/reoxygenation injury in vitro and increases graft size and vascularization in vivo","volume":"3","author":"Luo","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0835","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1016\/j.biomaterials.2013.02.022","article-title":"The use of aggregates of purified cardiomyocytes derived from human ESCs for functional engraftment after myocardial infarction","volume":"34","author":"Moon","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.004_bb0840","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.stem.2014.11.009","article-title":"Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells","volume":"15","author":"Ye","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0845","doi-asserted-by":"crossref","first-page":"e116281","DOI":"10.1371\/journal.pone.0116281","article-title":"Comparison of human induced pluripotent stem-cell derived cardiomyocytes with human mesenchymal stem cells following acute myocardial infarction","volume":"9","author":"Citro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0850","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nbt.2005","article-title":"SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells","volume":"29","author":"Dubois","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0855","doi-asserted-by":"crossref","first-page":"e23657","DOI":"10.1371\/journal.pone.0023657","article-title":"Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression","volume":"6","author":"Uosaki","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0860","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt.1835","article-title":"Karotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells","volume":"29","author":"Taapken","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0865","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1158\/0008-5472.CAN-04-0474","article-title":"Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells","volume":"64","author":"Upender","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.05.004_bb0870","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature13200","article-title":"Domains of genome-wide gene expression dysregulation in Down's syndrome","volume":"508","author":"Letourneau","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0875","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nm.1924","article-title":"Chromosome instability is common in human cleavage-stage embryos","volume":"15","author":"Vanneste","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0880","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1634\/stemcells.2005-0188","article-title":"Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells","volume":"24","author":"Drukker","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0885","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.stem.2013.11.014","article-title":"An effective approach to prevent immune rejection of human ESC-derived allografts","volume":"14","author":"Rong","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0890","doi-asserted-by":"crossref","first-page":"S324","DOI":"10.1016\/j.jaci.2009.11.014","article-title":"Transplantation immunology: solid organ and bone marrow","volume":"125","author":"Chinen","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.addr.2015.05.004_bb0895","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(05)67813-0","article-title":"Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching","volume":"366","author":"Taylor","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2015.05.004_bb0900","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1634\/stemcells.2006-0566","article-title":"Human leukocyte antigen matching estimations in a hypothetical bank of human embryonic stem cell lines in the Japanese population for use in cell transplantation therapy","volume":"25","author":"Nakajima","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0905","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5966\/sctm.2013-0127","article-title":"Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features","volume":"3","author":"Daughtry","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0910","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1634\/stemcells.2008-0421","article-title":"Regulatory issues for personalized pluripotent cells","volume":"26","author":"Condic","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0915","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature10135","article-title":"Immunogenicity of induced pluripotent stem cells","volume":"474","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0920","doi-asserted-by":"crossref","first-page":"e66369","DOI":"10.1371\/journal.pone.0066369","article-title":"Molecular imaging of induced pluripotent stem cell immunogenicity with in vivo development in ischemic myocardium","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.004_bb0925","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.stem.2013.01.006","article-title":"Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells","volume":"12","author":"Guha","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb0930","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nature11807","article-title":"Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells","volume":"494","author":"Araki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb0935","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1002\/stem.1501","article-title":"Costimulation\u2013adhesion blockade is superior to cyclosporine A and prednisone immunosuppressive therapy for preventing rejection of differentiated human embryonic stem cells following transplantation","volume":"31","author":"Huber","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.05.004_bb0940","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005090","article-title":"Pluripotent stem cells: immune to the immune system?","volume":"4","author":"Pearl","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb0945","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1242\/jcs.087718","article-title":"Immunobiology of naive and genetically modified HLA-class-I-knockdown human embryonic stem cells","volume":"124","author":"Deuse","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.addr.2015.05.004_bb0950","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s12015-013-9457-0","article-title":"Generating hypoimmunogenic human embryonic stem cells by the disruption of beta 2-microglobulin","volume":"9","author":"Lu","year":"2013","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.addr.2015.05.004_bb0955","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI40120","article-title":"A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates","volume":"120","author":"Blin","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2015.05.004_bb0960","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nbt.1667","article-title":"Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells","volume":"28","author":"Polo","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.004_bb0965","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jacc.2014.04.056","article-title":"Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cells","volume":"64","author":"Sanchez-Freire","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0970","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1089\/scd.2013.0125","article-title":"Epigenetic regulation of the electrophysiological phenotype of human embryonic stem cell-derived ventricular cardiomyocytes: insights for driven maturation and hypertrophic growth","volume":"22","author":"Chow","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2015.05.004_bb0975","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.jacc.2006.02.002","article-title":"Regeneration gaps: observations on stem cells and cardiac repair","volume":"47","author":"Murry","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0980","first-page":"I141","article-title":"The relationship of myocardial infarct size and prognosis","volume":"53","author":"Caulfield","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2015.05.004_bb0985","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0002-9440(10)62041-X","article-title":"Formation of human myocardium in the rat heart from human embryonic stem cells","volume":"167","author":"Laflamme","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2015.05.004_bb0990","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.yjmcc.2008.03.009","article-title":"Systems approaches to preventing transplanted cell death in cardiac repair","volume":"45","author":"Robey","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.addr.2015.05.004_bb0995","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2217\/rme.10.91","article-title":"Efficient generation and cryopreservation of cardiomyocytes derived from human embryonic stem cells","volume":"6","author":"Xu","year":"2011","journal-title":"Regen. Med."},{"key":"10.1016\/j.addr.2015.05.004_bb1000","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/7651_2014_118","article-title":"The suspension culture of undifferentiated human pluripotent stem cells using spinner flasks","volume":"1283","author":"Chen","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.addr.2015.05.004_bb1005","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.stemcr.2014.09.017","article-title":"Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture","volume":"3","author":"Kempf","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.addr.2015.05.004_bb1010","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1039\/c2ib20191g","article-title":"Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning","volume":"5","author":"Myers","year":"2013","journal-title":"Integr. Biol. (Camb.)"},{"key":"10.1016\/j.addr.2015.05.004_bb1015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jbiosc.2012.08.018","article-title":"Comparative analysis of cardiomyocyte differentiation from human embryonic stem cells under 3-D and 2-D culture conditions","volume":"115","author":"Pal","year":"2013","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.addr.2015.05.004_bb1020","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1089\/ten.tec.2010.0104","article-title":"Scalable platform for human embryonic stem cell differentiation to cardiomyocytes in suspended microcarrier cultures","volume":"16","author":"Lecina","year":"2010","journal-title":"Tissue Eng. Part C Methods"},{"key":"10.1016\/j.addr.2015.05.004_bb1025","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s12015-014-9533-0","article-title":"Combining hypoxia and bioreactor hydrodynamics boosts induced pluripotent stem cell differentiation towards cardiomyocytes","volume":"10","author":"Correia","year":"2014","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.addr.2015.05.004_bb1030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.05.004_bb1035","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.004_bb1040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X15000976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X15000976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T02:55:12Z","timestamp":1651978512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X15000976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":207,"alternative-id":["S0169409X15000976"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2015.05.004","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2015.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}