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Surg."},{"key":"10.1016\/j.addr.2015.05.013_bb0400","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.biomaterials.2010.10.052","article-title":"Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants","volume":"32","author":"Macdonald","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0405","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/jbm.a.32798","article-title":"Epidermal and dermal integration into sphere-templated porous poly(2-hydroxyethyl methacrylate) implants in mice","volume":"94","author":"Fukano","year":"2010","journal-title":"J. Biomed. Mater. Res. 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Exp. Med."},{"key":"10.1016\/j.addr.2015.05.013_bb0480","doi-asserted-by":"crossref","first-page":"8540","DOI":"10.1016\/j.biomaterials.2012.07.039","article-title":"Selective local delivery of RANK siRNA to bone phagocytes using bone augmentation biomaterials","volume":"33","author":"Wang","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0485","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2353\/ajpath.2007.061213","article-title":"Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation","volume":"171","author":"Jay","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2015.05.013_bb0490","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jconrel.2010.08.019","article-title":"Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation","volume":"147","author":"Takahashi","year":"2010","journal-title":"J. Control. 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A"},{"key":"10.1016\/j.addr.2015.05.013_bb0510","first-page":"111","article-title":"Pathophysiological aspects of hip implants","volume":"15","author":"Sargeant","year":"2006","journal-title":"J. Surg. Orthop. Adv."},{"key":"10.1016\/j.addr.2015.05.013_bb0515","doi-asserted-by":"crossref","first-page":"e2438","DOI":"10.1371\/journal.pone.0002438","article-title":"Immunogenecity of modified alkane polymers is mediated through TLR1\/2 activation","volume":"3","author":"Maitra","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.05.013_bb0520","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jbm.a.32409","article-title":"Ectopic expression of macrophage scavenger receptor MARCO in synovial membrane-like interface tissue in aseptic loosening of total hip replacement implants","volume":"92","author":"Zhao","year":"2010","journal-title":"J. Biomed. Mater. Res. 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Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0535","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1016\/S0142-9612(02)00097-2","article-title":"Cytotoxicity and MMP-9 activation induced in human mononuclear cells by UHMWPE oxidation","volume":"23","author":"Reno","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0540","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0142-9612(02)00526-4","article-title":"In vitro evaluation of the inflammatory activity of ultra-high molecular weight polyethylene","volume":"24","author":"Bosetti","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0545","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2106\/JBJS.A.02039pp","article-title":"Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study","volume":"87","author":"Willert","year":"2005","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.addr.2015.05.013_bb0550","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.2106\/JBJS.I.00695","article-title":"Postmortem study of femoral osteolysis associated with metal-on-metal articulation in total hip replacement: an analysis of nine cases","volume":"92","author":"Huber","year":"2010","journal-title":"J. Bone Joint Surg. Am. Vol."},{"key":"10.1016\/j.addr.2015.05.013_bb0555","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1016\/j.biomaterials.2010.03.046","article-title":"Cellular chemotaxis induced by wear particles from joint replacements","volume":"31","author":"Goodman","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0560","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bone.2009.05.020","article-title":"Co-Cr-Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: a role for osteocytes in particle-induced inflammation","volume":"45","author":"Kanaji","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.addr.2015.05.013_bb0565","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jbm.a.32531","article-title":"In vivo response to cross-linked polyethylene and polycarbonate-urethane particles","volume":"93","author":"Smith","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2015.05.013_bb0570","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jbm.a.31996","article-title":"Response of human osteoblasts exposed to wear particles generated at the interface of total hip stems and bone cement","volume":"89","author":"Lenz","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2015.05.013_bb0575","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1002\/jbm.a.34599","article-title":"Macrophages\u2014key cells in the response to wear debris from joint replacements","volume":"101","author":"Nich","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2015.05.013_bb0580","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/672395","article-title":"DAMPening inflammation by modulating TLR signalling","volume":"2010","author":"Piccinini","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.addr.2015.05.013_bb0585","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.biomaterials.2004.04.035","article-title":"The role of macrophages in osteolysis of total joint replacement","volume":"26","author":"Ingham","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0590","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.4049\/jimmunol.107.6.1547","article-title":"The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces","volume":"107","author":"Henson","year":"1971","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0595","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1755-1536-2-5","article-title":"Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty","volume":"2","author":"Freeman","year":"2009","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.addr.2015.05.013_bb0600","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1126\/science.1158398","article-title":"Immunology. How frustration leads to inflammation","volume":"320","author":"O'Neill","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.05.013_bb0605","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jor.20826","article-title":"Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity","volume":"27","author":"Caicedo","year":"2009","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0610","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-065X.2008.00730.x","article-title":"Inflammasomes: guardians of cytosolic sanctity","volume":"227","author":"Lamkanfi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.addr.2015.05.013_bb0615","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molimm.2009.09.023","article-title":"Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis","volume":"47","author":"Maitra","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0620","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.292.4.490","article-title":"Clinical implications of the osteoprotegerin\/RANKL\/RANK system for bone and vascular diseases","volume":"292","author":"Hofbauer","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2015.05.013_bb0625","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jbm.a.32001","article-title":"Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro","volume":"89","author":"Chiu","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2015.05.013_bb0630","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jbm.a.32063","article-title":"Biocompatibility of total joint replacements: a review","volume":"90","author":"Goodman","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2015.05.013_bb0635","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/01.blo.0000150451.50452.da","article-title":"The microenvironment around total hip replacement prostheses","author":"Konttinen","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0640","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1359\/jbmr.1999.14.2.288","article-title":"Expression of gelatinase A and its activator MT1-MMP in the inflammatory periprosthetic response to polyethylene","volume":"14","author":"Nawrocki","year":"1999","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0645","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/1097-4636(20001215)52:4<613::AID-JBM5>3.0.CO;2-8","article-title":"Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone\u2013implant interface tissues of loose artificial hip joints","volume":"52","author":"Takei","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0650","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0736-0266(02)00240-1","article-title":"Polyethylene cross-linking by two different methods reduces acetabular liner wear in a hip joint wear simulator","volume":"21","author":"D'Lima","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0655","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1016\/j.biomaterials.2003.10.054","article-title":"The influence of molecular weight, crosslinking and counterface roughness on TNF-alpha production by macrophages in response to ultra high molecular weight polyethylene particles","volume":"25","author":"Ingram","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0660","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.arth.2006.07.005","article-title":"Damage of oxinium femoral heads subsequent to hip arthroplasty dislocation three retrieval case studies","volume":"22","author":"Kop","year":"2007","journal-title":"J. Arthroplast."},{"key":"10.1016\/j.addr.2015.05.013_bb0665","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1007\/s10856-008-3417-2","article-title":"On the possibility of silicon nitride as a ceramic for structural orthopaedic implants. Part I: processing, microstructure, mechanical properties, cytotoxicity","volume":"19","author":"Mazzocchi","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.addr.2015.05.013_bb0670","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1874325000802010043","article-title":"Load-bearing biomedical applications of diamond-like carbon coatings\u2014current status","volume":"2","author":"Alakoski","year":"2008","journal-title":"Open Orthop. J."},{"key":"10.1016\/j.addr.2015.05.013_bb0675","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0142-9612(99)00246-X","article-title":"The in-vivo wear performance of prosthetic femoral heads with titanium nitride coating","volume":"21","author":"Raimondi","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0680","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1016\/j.biomaterials.2012.02.034","article-title":"Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine","volume":"33","author":"Brown","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0685","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0142-9612(99)00152-0","article-title":"Evaluation of protein-modulated macrophage behavior on biomaterials: designing biomimetic materials for cellular engineering","volume":"20","author":"Kao","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0690","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jbm.a.32971","article-title":"Macrophage and dendritic cell phenotypic diversity in the context of biomaterials","volume":"96","author":"Kou","year":"2011","journal-title":"J. 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A."},{"key":"10.1016\/j.addr.2015.05.013_bb0725","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.actbio.2011.11.031","article-title":"Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials","volume":"8","author":"Brown","year":"2012","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2015.05.013_bb0730","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1016\/j.biomaterials.2008.07.010","article-title":"Topographical control of human macrophages by a regularly microstructured polyvinylidene fluoride surface","volume":"29","author":"Paul","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2015.05.013_bb0735","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0740","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/cvr\/cvt161","article-title":"MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease","volume":"100","author":"Hulsmans","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0750","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2015.05.013_bb0760","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/CIRCRESAHA.111.251546","article-title":"Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132","volume":"109","author":"Katare","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0770","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jconrel.2013.09.015","article-title":"Progress in microRNA delivery","volume":"172","author":"Zhang","year":"2013","journal-title":"J. Control. 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(Baltimore, Md.: 1950)"},{"key":"10.1016\/j.addr.2015.05.013_bb0830","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.4049\/jimmunol.0900707","article-title":"MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2","volume":"183","author":"Hou","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0835","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/art.24436","article-title":"MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins","volume":"60","author":"Tang","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.addr.2015.05.013_bb0840","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.1300613","article-title":"Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation","volume":"192","author":"Das","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0845","doi-asserted-by":"crossref","first-page":"7956","DOI":"10.1074\/jbc.M112.445429","article-title":"MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase","volume":"288","author":"Lai","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2015.05.013_bb0850","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4049\/jimmunol.1102348","article-title":"TLR2 expression is regulated by microRNA miR-19 in rheumatoid fibroblast-like synoviocytes","volume":"188","author":"Philippe","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0855","doi-asserted-by":"crossref","first-page":"23107","DOI":"10.1074\/jbc.M109.013862","article-title":"Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes","volume":"284","author":"Benakanakere","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2015.05.013_bb0860","doi-asserted-by":"crossref","first-page":"28929","DOI":"10.1074\/jbc.M702633200","article-title":"A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection","volume":"282","author":"Chen","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2015.05.013_bb0865","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.4049\/jimmunol.1201516","article-title":"NLRP3 inflammasome activity is negatively controlled by miR-223","volume":"189","author":"Bauernfeind","year":"2012","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.addr.2015.05.013_bb0870","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.4049\/jimmunol.1200312","article-title":"Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1\u03b2 production","volume":"189","author":"Haneklaus","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0875","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbrc.2013.08.056","article-title":"MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2","volume":"439","author":"Bandyopadhyay","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2015.05.013_bb0880","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bbagrm.2014.08.002","article-title":"MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation","volume":"1839","author":"Dou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2015.05.013_bb0885","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4049\/jimmunol.1102477","article-title":"Cutting edge: microRNA regulation of macrophage fusion into multinucleated giant cells","volume":"189","author":"Sissons","year":"2012","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.addr.2015.05.013_bb0890","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.20050645","article-title":"DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells","volume":"202","author":"Yagi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.addr.2015.05.013_bb0895","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/bit.25175","article-title":"Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype","volume":"111","author":"Boehler","year":"2014","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2015.05.013_bb0900","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.febslet.2011.05.029","article-title":"MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation","volume":"585","author":"Liu","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2015.05.013_bb0755","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.4049\/jimmunol.0902308","article-title":"MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation","volume":"184","author":"Ma","year":"2010","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.addr.2015.05.013_bb0905","first-page":"145","article-title":"The role of microRNAs in the control and mechanism of action of IL-10","volume":"380","author":"Quinn","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0910","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.4049\/jimmunol.1203450","article-title":"Type I IFN inhibits innate IL-10 production in macrophages through histone deacetylase 11 by downregulating microRNA-145","volume":"191","author":"Lin","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0915","doi-asserted-by":"crossref","first-page":"E3101","DOI":"10.1073\/pnas.1209100109","article-title":"IL-10-induced microRNA-187 negatively regulates TNF-\u03b1, IL-6, and IL-12p40 production in TLR4-stimulated monocytes","volume":"109","author":"Rossato","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.013_bb0920","first-page":"11499","article-title":"Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b","volume":"110","author":"Curtale","year":"2013"},{"key":"10.1016\/j.addr.2015.05.013_bb0925","doi-asserted-by":"crossref","first-page":"20492","DOI":"10.1074\/jbc.M110.102111","article-title":"IL-10 inhibits miR-155 induction by toll-like receptors","volume":"285","author":"McCoy","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2015.05.013_bb0930","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.4049\/jimmunol.1100922","article-title":"Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10\u2212\/\u2212 mice precedes expression in the colon","volume":"187","author":"Schaefer","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2015.05.013_bb0935","doi-asserted-by":"crossref","first-page":"E2110","DOI":"10.1073\/pnas.1209414109","article-title":"MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response","volume":"109","author":"Fabbri","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.05.013_bb0940","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/clpt.2008.174","article-title":"Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides","volume":"84","author":"Sepp-Lorenzino","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2015.05.013_bb0945","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.neuroscience.2004.11.038","article-title":"Spinal distribution and metabolism of 2\u2032-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats","volume":"131","author":"Butler","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.addr.2015.05.013_bb0950","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1076\/ceyr.26.1.45.14252","article-title":"Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization","volume":"26","author":"Danis","year":"2002","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.addr.2015.05.013_bb0955","first-page":"585","article-title":"Medicinal chemistry of antisense oligonucleotides\u2014future opportunities","volume":"6","author":"Cook","year":"1991","journal-title":"Anticancer Drug Des."},{"key":"10.1016\/j.addr.2015.05.013_bb0765","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/PPO.0b013e318258b5d6","article-title":"The therapeutic potential of microRNAs in cancer","volume":"18","author":"Thorsen","year":"2012","journal-title":"Cancer J. (Sudbury, Mass.)"},{"key":"10.1016\/j.addr.2015.05.013_bb0960","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1261\/rna.789808","article-title":"Strand-specific 5\u2032-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity","volume":"14","author":"Chen","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.addr.2015.05.013_bb0965","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1261\/rna.2340906","article-title":"Induction of the interferon response by siRNA is cell type- and duplex length-dependent","volume":"12","author":"Reynolds","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.addr.2015.05.013_bb0970","first-page":"9200","article-title":"Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic","volume":"133","author":"Peacock","year":"2011","journal-title":"RNA"},{"key":"10.1016\/j.addr.2015.05.013_bb0975","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/onc.2009.445","article-title":"Regression of murine lung tumors by the let-7 microRNA","volume":"29","author":"Trang","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.addr.2015.05.013_bb0980","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.05.013_bb0985","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/nm.2791","article-title":"Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2","volume":"18","author":"Miyazaki","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2015.05.013_bb0990","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nm1549","article-title":"CD8(+) T-cell responses to adeno-associated virus capsid in humans","volume":"13","author":"Mingozzi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2015.05.013_bb0995","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3899\/jrheum.090817","article-title":"Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1\/2 study","volume":"37","author":"Mease","year":"2010","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.addr.2015.05.013_bb1000","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/gt.2011.50","article-title":"MicroRNA therapeutics","volume":"18","author":"Broderick","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.addr.2015.05.013_bb1005","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1007\/s11095-010-0156-0","article-title":"A direct comparison of anti-microRNA oligonucleotide potency","volume":"27","author":"Lennox","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1010","first-page":"1111","article-title":"Chemical modification and design of anti-miRNA","volume":"18","author":"Lennox","year":"2011","journal-title":"Oligonucleotides"},{"key":"10.1016\/j.addr.2015.05.013_bb1015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u2018antagomirs\u2019","volume":"438","author":"Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.013_bb1020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","article-title":"Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs","volume":"432","author":"Soutschek","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.013_bb1025","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1093\/nar\/gkm024","article-title":"Specificity, duplex degradation and subcellular localization of antagomirs","volume":"35","author":"Kr\u00fctzfeldt","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1030","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1093\/nar\/gkl183","article-title":"Improved targeting of miRNA with antisense oligonucleotides","volume":"34","author":"Davis","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.gene.2005.12.031","article-title":"LNA-modified oligonucleotides mediate specific inhibition of microRNA function","volume":"372","author":"\u00d8rom","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.addr.2015.05.013_bb1040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nature06783","article-title":"LNA-mediated microRNA silencing in non-human primates","volume":"452","author":"Elm\u00e9n","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.05.013_bb1045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1126\/science.1178178","article-title":"Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection","volume":"327","author":"Lanford","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.05.013_bb1050","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1093\/nar\/gkp577","article-title":"Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c\/ebp Beta and down-regulation of G-CSF","volume":"37","author":"Worm","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1055","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2015.05.013_bb1060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MOL.0b013e328350a425","article-title":"Lipid-based carriers of microRNAs and intercellular communication","volume":"23","author":"Vickers","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.addr.2015.05.013_bb1065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/15227950290097606","article-title":"Liposome-mediated delivery of oligodeoxynucleotides in vivo","volume":"9","author":"Dass","year":"2002","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2015.05.013_bb1070","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1158\/1078-0432.CCR-05-1260","article-title":"Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies","volume":"12","author":"Dritschilo","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1075","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1158\/1535-7163.MCT-11-0152","article-title":"Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice","volume":"10","author":"Pramanik","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.addr.2015.05.013_bb1080","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcb.22733","article-title":"Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy","volume":"111","author":"Tian","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.addr.2015.05.013_bb1085","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood-2011-02-338004","article-title":"Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes","volume":"119","author":"Montecalvo","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.addr.2015.05.013_bb1090","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","article-title":"MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins","volume":"13","author":"Vickers","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2015.05.013_bb1095","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2006.04.014","article-title":"Toxicity of cationic lipids and cationic polymers in gene delivery","volume":"114","author":"Lv","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2015.05.013_bb1100","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/mt.2011.48","article-title":"Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice","volume":"19","author":"Trang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.addr.2015.05.013_bb1105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nbt0713-577","article-title":"First microRNA mimic enters clinic","author":"Bouchie","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2015.05.013_bb1110","first-page":"2231","article-title":"Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity","volume":"119","author":"Cubillos-Ruiz","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2015.05.013_bb1115","first-page":"484","article-title":"Polyethylenimines for siRNA and miRNA delivery in vivo","volume":"5","author":"H\u00f6bel","year":"2013"},{"key":"10.1016\/j.addr.2015.05.013_bb1120","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1158\/0008-5472.CAN-10-4645","article-title":"MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma","volume":"71","author":"Ibrahim","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.05.013_bb1125","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4161\/onci.20020","article-title":"Good things come in small packages: therapeutic anti-tumor immunity induced by microRNA nanoparticles","volume":"1","author":"Cubillos-Ruiz","year":"2012","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.addr.2015.05.013_bb1130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jconrel.2008.04.002","article-title":"High loading efficiency and tunable release of plasmid DNA encapsulated in submicron particles fabricated from PLGA conjugated with poly-L-lysine","volume":"129","author":"Blum","year":"2008","journal-title":"J. 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