{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:14Z","timestamp":1792784714111,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["23-A-12"],"award-info":[{"award-number":["23-A-12"]}]},{"name":"National Cancer Center Research and Development Fund","award":["23-K-18"],"award-info":[{"award-number":["23-K-18"]}]},{"name":"National Cancer Center Research and Development Fund","award":["26-A-16"],"award-info":[{"award-number":["26-A-16"]}]},{"DOI":"10.13039\/501100006062","name":"Foundation for the Promotion of Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"3rd-Term Comprehensive 10-Year Strategy for Cancer Control","award":["H22-009"],"award-info":[{"award-number":["H22-009"]}]},{"name":"Program for the Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation","award":["09-18"],"award-info":[{"award-number":["09-18"]}],"id":[{"id":"https:\/\/ror.org\/00xvd7584","id-type":"ROR","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["24659185"],"award-info":[{"award-number":["24659185"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.addr.2015.07.007","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T01:00:32Z","timestamp":1439514032000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":381,"special_numbering":"PB","title":["Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment"],"prefix":"10.1016","volume":"99","author":[{"given":"Genichiro","family":"Ishii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2015.07.007_bb0005","first-page":"1571","article-title":"The distribution of secondary growths in cancer of the breast","author":"Paget","year":"1889","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2015.07.007_bb0010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1090922","article-title":"TGF-\u03b2 signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia","volume":"303","author":"Bhowmick","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.07.007_bb0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI117736","article-title":"The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells","volume":"95","author":"Ronnov-Jessen","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2015.07.007_bb0020","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4161\/cbt.6.4.4255","article-title":"Heterogeneity of stromal fibroblasts in tumors","volume":"6","author":"Orimo","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.addr.2015.07.007_bb0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0006-291X(03)01544-4","article-title":"Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction","volume":"309","author":"Ishii","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2015.07.007_bb0035","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1634\/stemcells.2006-0449","article-title":"Presence of human circulating progenitor cells for cancer stromal fibroblasts in the blood of lung cancer patients","volume":"25","author":"Ishii","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2015.07.007_bb0040","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.4161\/cbt.5.12.3354","article-title":"Identification of fibroblast heterogeneity in the tumor microenvironment","volume":"5","author":"Sugimoto","year":"2006","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.addr.2015.07.007_bb0045","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/jcp.24347","article-title":"Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells","volume":"228","author":"Polanska","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.addr.2015.07.007_bb0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fonc.2014.00062","article-title":"Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment","volume":"4","author":"Augsten","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.addr.2015.07.007_bb0055","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/ijc.23611","article-title":"Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma","volume":"123","author":"Kawase","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0060","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1378\/chest.12-0913","volume":"143","author":"Ono","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.addr.2015.07.007_bb0065","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1111\/j.1365-2559.2011.04060.x","article-title":"Podoplanin expression by cancer-associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma","volume":"59","author":"Pula","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.addr.2015.07.007_bb0070","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1158\/0008-5472.CAN-10-3228","article-title":"Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression","volume":"71","author":"Hoshino","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0075","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s13277-012-0638-2","article-title":"High intratumoral expression of fibroblast activation protein (FAP) in colon cancer is associated with poorer patient prognosis","volume":"34","author":"Wikberg","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.addr.2015.07.007_bb0080","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/pros.20946","article-title":"Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts","volume":"69","author":"Zhao","year":"2009","journal-title":"Prostate"},{"key":"10.1016\/j.addr.2015.07.007_bb0085","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.07.007_bb0090","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1038\/ncomms4472","article-title":"Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2015.07.007_bb0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1158\/0008-5472.CAN-14-0350","article-title":"Twist1 is a key regulator of cancer-associated fibroblasts","volume":"75","author":"Lee","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0100","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/ncomms2766","article-title":"Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis","volume":"4","author":"Jung","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2015.07.007_bb0105","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.18632\/oncotarget.2052","article-title":"Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells","volume":"5","author":"Maxwell","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2015.07.007_bb0110","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1073\/pnas.1013805107","article-title":"Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts","volume":"107","author":"Kojima","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.07.007_bb0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","article-title":"Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion","volume":"121","author":"Orimo","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0120","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/bjc.2013.768","article-title":"Cancer-associated fibroblasts induce epithelial\u2013mesenchymal transition of breast cancer cells through paracrine TGF-\u03b2 signalling","volume":"110","author":"Yu","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0125","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng.3225","article-title":"Stromal gene expression defines poor-prognosis subtypes in colorectal cancer","volume":"47","author":"Calon","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.addr.2015.07.007_bb0130","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ccr.2012.08.013","article-title":"Dependency of colorectal cancer on a TGF-\u03b2-driven program in stromal cells for metastasis initiation","volume":"22","author":"Calon","year":"2012","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.addr.2015.07.007_bb0135","doi-asserted-by":"crossref","first-page":"e15313","DOI":"10.1371\/journal.pone.0015313","article-title":"Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis","volume":"6","author":"Tyan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.07.007_bb0140","doi-asserted-by":"crossref","first-page":"e63243","DOI":"10.1371\/journal.pone.0063243","article-title":"Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion","volume":"8","author":"Jia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.07.007_bb0145","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.canlet.2013.02.002","article-title":"Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer","volume":"335","author":"Wu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.addr.2015.07.007_bb0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12885-015-1065-8","article-title":"The role of HGF\/MET and FGF\/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma","volume":"15","author":"Saito","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0155","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.cell.2012.11.024","article-title":"Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration","volume":"151","author":"Luga","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/1541-7786.MCR-10-0372","article-title":"Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers","volume":"9","author":"Camp","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0165","doi-asserted-by":"crossref","first-page":"18691","DOI":"10.1073\/pnas.1412062112","article-title":"TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion","volume":"111","author":"Otomo","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.07.007_bb0170","doi-asserted-by":"crossref","first-page":"21677","DOI":"10.1073\/pnas.1016234107","article-title":"Malignant cells facilitate lung metastasis by bringing their own soil","volume":"107","author":"Duda","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.07.007_bb0175","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1476-4598-13-238","article-title":"Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL\/OPG ratio in human breast cancer cells generating bone metastases","volume":"13","author":"Arrigoni","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0180","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha","volume":"330","author":"Kraman","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.addr.2015.07.007_bb0185","doi-asserted-by":"crossref","first-page":"20212","DOI":"10.1073\/pnas.1320318110","article-title":"Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer","volume":"110","author":"Feig","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.07.007_bb0190","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/cas.12099","article-title":"Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma","volume":"104","author":"Kinoshita","year":"2013","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2015.07.007_bb0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2009.12.041","article-title":"Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner","volume":"17","author":"Erez","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0200","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1002\/ijc.24589","article-title":"Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion","volume":"125","author":"Vosseler","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0205","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cell.2004.12.018","article-title":"PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells","volume":"120","author":"Boire","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0210","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/ncb1658","article-title":"Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells","volume":"9","author":"Gaggioli","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2015.07.007_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.29464","article-title":"Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma","author":"Neri","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0220","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1073\/pnas.1303671110","article-title":"Paracrine Wnt signaling both promotes and inhibits human breast tumor growth","volume":"110","author":"Green","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2015.07.007_bb0225","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1038\/onc.2009.82","article-title":"Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma","volume":"28","author":"Akiri","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.addr.2015.07.007_bb0230","first-page":"3379","article-title":"Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis","volume":"59","author":"Engle","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0235","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1002\/ijc.25612","article-title":"High-throughput live-cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblasts","volume":"128","author":"Flaberg","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0240","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.18632\/oncotarget.3371","article-title":"Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth","volume":"6","author":"Takahashi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2015.07.007_bb0245","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature11183","article-title":"Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion","volume":"487","author":"Straussman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.addr.2015.07.007_bb0250","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.1158\/1078-0432.CCR-09-1001","article-title":"Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors","volume":"15","author":"Wang","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0255","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1158\/1078-0432.CCR-14-0846","article-title":"Podoplanin-positive cancer-associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation","volume":"21","author":"Yoshida","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0260","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/bjc.2013.768","article-title":"Cancer-associated fibroblasts induce epithelial\u2013mesenchymal transition of breast cancer cells through paracrine TGF-\u03b2 signaling","volume":"110","author":"Yu","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0265","doi-asserted-by":"crossref","first-page":"e0125625","DOI":"10.1371\/journal.pone.0125625","article-title":"Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer","volume":"10","author":"Hu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.07.007_bb0270","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/biomedicines2010036","article-title":"Oncolytic adenoviruses in cancer treatment","volume":"2","author":"Ramon","year":"2014","journal-title":"Biomedicines"},{"key":"10.1016\/j.addr.2015.07.007_bb0275","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00006676-200401000-00006","article-title":"Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins","volume":"28","author":"Miyamoto","year":"2004","journal-title":"Pancreas"},{"key":"10.1016\/j.addr.2015.07.007_bb0280","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood.V98.5.1532","article-title":"Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis","volume":"98","author":"van der Kuip","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.addr.2015.07.007_bb0285","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/0008-5472.CAN-10-1855","article-title":"Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2","volume":"71","author":"Dangi-Garimella","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0290","doi-asserted-by":"crossref","first-page":"e64566","DOI":"10.1371\/journal.pone.0064566","article-title":"Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression","volume":"8","author":"Dangi-Garimella","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2015.07.007_bb0295","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0300","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm.2890","article-title":"Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B","volume":"18","author":"Sun","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2015.07.007_bb0305","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1084\/jem.20131195","article-title":"Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A","volume":"210","author":"Lotti","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.addr.2015.07.007_bb0310","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2353\/ajpath.2007.061004","article-title":"Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity","volume":"170","author":"Shekhar","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2015.07.007_bb0315","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4161\/cbt.12.10.17780","article-title":"Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells","volume":"12","author":"Martinez-Outschoorn","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.addr.2015.07.007_bb0320","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/ijc.23546","article-title":"P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy","volume":"123","author":"Lafkas","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.addr.2015.07.007_bb0325","first-page":"689","article-title":"Mesenchymal stem cells and carcinoma-associated fibroblasts sensitize breast cancer cells in 3D cultures to kinase inhibitors","volume":"39","author":"Dittmer","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.addr.2015.07.007_bb0330","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1172\/JCI26532","article-title":"Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake","volume":"116","author":"Loeffler","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2015.07.007_bb0335","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1158\/0008-5472.CAN-12-2130","article-title":"Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma","volume":"73","author":"Mertens","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2015.07.007_bb0340","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1171362","article-title":"Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer","volume":"324","author":"Olive","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.addr.2015.07.007_bb0345","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cell.2014.08.007","article-title":"Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy","volume":"159","author":"Sherman","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.addr.2015.07.007_bb0350","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/bc200158j","article-title":"Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue","volume":"22","author":"Yasunaga","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2015.07.007_bb0355","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cas.12062","article-title":"Tailored immunoconjugate therapy depending on a quantity of tumor stroma","volume":"104","author":"Yasunaga","year":"2013","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2015.07.007_bb0360","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/ijc.21199","article-title":"In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma","volume":"117","author":"Ishii","year":"2005","journal-title":"Int. J. Cancer"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1500160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X1500160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T06:29:35Z","timestamp":1567060175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X1500160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":71,"alternative-id":["S0169409X1500160X"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2015.07.007","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2015.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}