{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:18:52Z","timestamp":1793837932567,"version":"4.6.1"},"reference-count":689,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science Foundation Ireland Centre for Medical Devices (CURAM)","award":["13\/RC\/2073"],"award-info":[{"award-number":["13\/RC\/2073"]}],"id":[{"id":"https:\/\/ror.org\/0271asj38","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["281035"],"award-info":[{"award-number":["281035"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RCSI School of Pharmacy"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.addr.2016.06.005","type":"journal-article","created":{"date-parts":[[2016,6,19]],"date-time":"2016-06-19T23:36:04Z","timestamp":1466379364000},"page":"277-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":378,"special_numbering":"PB","title":["Intestinal permeation enhancers for oral peptide delivery"],"prefix":"10.1016","volume":"106","author":[{"given":"Sam","family":"Maher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Mrsny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2016.06.005_bb0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0169-409X(92)90015-I","article-title":"(C) Means to enhance penetration: (2) intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity","volume":"8","author":"Swenson","year":"1992","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0010","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4155\/ppa.14.15","article-title":"Formulation strategies to improve oral peptide delivery","volume":"3","author":"Maher","year":"2014","journal-title":"Pharm. Pat. Anal."},{"key":"10.1016\/j.addr.2016.06.005_bb0015","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1210\/jc.2012-1179","article-title":"Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression","volume":"97","author":"Tuvia","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2016.06.005_bb0020","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.addr.2016.02.004","article-title":"Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials","volume":"106","author":"Aguirre","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2016.06.005_bb0030","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4155\/tde.14.111","article-title":"Challenges in the delivery of peptide drugs: an industry perspective","volume":"6","author":"Lewis","year":"2015","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4155\/tde.14.5","article-title":"Recent developments in protein and peptide parenteral delivery approaches","volume":"5","author":"Patel","year":"2014","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0040","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1089\/dia.2013.0081","article-title":"Clinical evidence for the earlier initiation of insulin therapy in type 2 diabetes","volume":"15","author":"Owens","year":"2013","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MED.0b013e328322f92e","article-title":"Pro's and con's of the early use of insulin in the management of type 2 diabetes: a clinical evaluation","volume":"16","author":"Davidson","year":"2009","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.addr.2016.06.005_bb0050","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/193229680900300322","article-title":"Oral insulin: the rationale for this approach and current developments","volume":"3","author":"Arbit","year":"2009","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.addr.2016.06.005_bb0055","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrd836","article-title":"New horizons--alternative routes for insulin therapy","volume":"1","author":"Owens","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2016.06.005_bb0060","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.bmcl.2013.05.022","article-title":"Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity","volume":"23","author":"Lorenz","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.addr.2016.06.005_bb0065","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/mp500809f","article-title":"Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs","volume":"12","author":"Wang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1517\/17425247.2.1.29","article-title":"Commercial challenges of protein drug delivery","volume":"2","author":"Brown","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0075","doi-asserted-by":"crossref","first-page":"e59524","DOI":"10.1371\/journal.pone.0059524","article-title":"Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study","volume":"8","author":"Eldor","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2016.06.005_bb0080","article-title":"A Single-Blind, Two-Period Study to Assess the Safety and Pharmacodynamics of an Orally Delivered GLP-1 Analog (Exenatide) in Healthy Subjects","author":"Eldor","year":"2010","journal-title":"70th Meeting of the American Diabetes Association (Florida, USA)"},{"key":"10.1016\/j.addr.2016.06.005_bb0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1517\/17425247.2013.736962","article-title":"Eudragit: a technology evaluation","volume":"10","author":"Thakral","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0090","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-5173(86)90069-4","article-title":"Targeted enteral delivery of insulin to rats","volume":"30","author":"Touitou","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0100","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1248\/bpb.16.68","article-title":"Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin","volume":"16","author":"Morishita","year":"1993","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb0105","first-page":"61","article-title":"Enzymatic barriers for GI peptide and protein delivery","volume":"11","author":"Woodley","year":"1994","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2016.06.005_bb0110","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-3-642-00477-3_12","article-title":"Improving oral delivery","author":"Gabor","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0115","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1023\/A:1018968611962","article-title":"Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats","volume":"11","author":"Yamamoto","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0120","series-title":"Oral Delivery of Macromolecular Drugs","first-page":"65","article-title":"Strategies to Overcome the Enzymatic Barrier","author":"Werle","year":"2009"},{"key":"10.1016\/j.addr.2016.06.005_bb0125","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ejpb.2013.12.017","article-title":"The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition","volume":"86","author":"Welling","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0130","unstructured":"Oramed Ltd US20110046053 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1211\/146080800128735935","article-title":"Oral delivery of proteins: effect of chicken and duck ovomucoid on the stability of insulin in the presence of \u03b1-chymotrypsin and trypsin","volume":"6","author":"Agarwal","year":"2000","journal-title":"Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.addr.2016.06.005_bb0140","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1211\/0022357022052","article-title":"Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats","volume":"55","author":"Liu","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jat.2550090307","article-title":"Hypertrophy and hyperplasia of the rat pancreas produced by short-term dietary administration of soya-derived protein and soybean trypsin inhibitor","volume":"9","author":"Smith","year":"1989","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.addr.2016.06.005_bb0155","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0304-4165(76)90294-4","article-title":"Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soybean trypsin inhibitor","volume":"421","author":"Melmed","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10611860701349141","article-title":"Design and evaluation of a chitosan-aprotinin conjugate for the peroral delivery of therapeutic peptides and proteins susceptible to enzymatic degradation","volume":"15","author":"Werle","year":"2007","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2016.06.005_bb0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/10611869808997895","article-title":"Development and in vitro evaluation of a drug delivery system based on chitosan\u2013EDTA BBI conjugate","volume":"6","author":"Bernkop-Schnurch","year":"1998","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2016.06.005_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0168-3659(96)01352-1","article-title":"Structural requirements for intestinal absorption of peptide drugs","volume":"41","author":"Pauletti","year":"1996","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0175","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(96)01586-6","article-title":"The challenge of proteolytic enzymes in intestinal peptide delivery","volume":"46","author":"Langguth","year":"1997","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0180","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1211\/0022357011776522","article-title":"Transport studies of insulin across rat jejunum in the presence of chicken and duck ovomucoids","volume":"53","author":"Agarwal","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0185","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0006-2952(87)90411-4","article-title":"Absorption of protein via the intestinal wall. A quantitative model","volume":"36","author":"Ziv","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0190","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/bm301024x","article-title":"Lamellar structures of MUC2-rich mucin: a potential role in governing the barrier and lubricating functions of intestinal mucus","volume":"13","author":"Round","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.addr.2016.06.005_bb0195","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","article-title":"Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0200","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ejpb.2015.01.014","article-title":"Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation","volume":"95","author":"Boegh","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0205","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijpharm.2005.03.004","article-title":"Role of the mucous\/glycocalyx layers in insulin permeation across the rat ileal membrane","volume":"297","author":"Aoki","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0210","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1021\/js960503w","article-title":"Diffusion of drugs in native and purified gastrointestinal mucus","volume":"86","author":"Larhed","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2005.07.008","article-title":"Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant","volume":"62","author":"Takatsuka","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0220","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2006.02.053","article-title":"Synergistic absorption enhancement of salmon calcitonin and reversible mucosal injury by applying a mucolytic agent and a non-ionic surfactant","volume":"316","author":"Takatsuka","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0225","first-page":"799","article-title":"Peroral polypeptide delivery. A comparative in vitro study of mucolytic agents","volume":"49","author":"Bernkop-Schnurch","year":"1999","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.addr.2016.06.005_bb0230","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.addr.2016.03.011","article-title":"How to design the surface of peptide-loaded nanoparticles for efficient oral bioavailability?","volume":"106","author":"Malhaire","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0240","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-004-9004-4","article-title":"Predicting drug disposition via application of BCS: transport\/absorption\/ elimination interplay and development of a biopharmaceutics drug disposition classification system","volume":"22","author":"Wu","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0250","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1002\/jps.22217","article-title":"The developability classification system: application of biopharmaceutics concepts to formulation development","volume":"99","author":"Butler","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0255","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-food-032814-014043","article-title":"The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability","volume":"6","author":"McClements","year":"2015","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.addr.2016.06.005_bb0260","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead- and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.addr.2016.06.005_bb0265","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1023\/A:1007596821702","article-title":"Regional differences in intestinal spreading and pH recovery and the impact on salmon calcitonin absorption in dogs","volume":"17","author":"Lee","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0270","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11095-007-9523-x","article-title":"The use of BDDCS in classifying the permeability of marketed drugs","volume":"25","author":"Benet","year":"2008","journal-title":"Pharm. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2016.06.005_bb0275","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0169-409X(01)00178-8","article-title":"The drug efflux-metabolism alliance: biochemical aspects","volume":"50","author":"Benet","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0280","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0041-1345(98)00393-5","article-title":"Modification of the pharmacokinetics of cyclosporine A and metabolites by the concomitant use of Neoral and diltiazem or ketoconazol in stable adult kidney transplants","volume":"30","author":"Foradori","year":"1998","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.addr.2016.06.005_bb0285","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bdd.302","article-title":"The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats","volume":"23","author":"Lee","year":"2002","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2016.06.005_bb0290","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1023\/A:1018991713064","article-title":"Enhanced bioavailability of cefoxitin using palmitoylcarnitine. II. Use of directly compressed tablet formulations in the rat and dog","volume":"10","author":"Sutton","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0295","series-title":"Biopharmaceutics Applications in Drug Development","first-page":"139","article-title":"Excipients as Absorption Enhancers","author":"Junginger","year":"2008"},{"key":"10.1016\/j.addr.2016.06.005_bb0300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v20.i23.30","article-title":"Emerging trends in oral delivery of peptide and protein drugs","volume":"20","author":"Mahato","year":"2003","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2016.06.005_bb0305","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.27.8.886","article-title":"Transit of pharmaceutical dosage forms through the small intestine","volume":"27","author":"Davis","year":"1986","journal-title":"Gut"},{"key":"10.1016\/j.addr.2016.06.005_bb0310","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4155\/tde.10.5","article-title":"Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate","volume":"1","author":"Wang","year":"2010","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0315","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-5173(91)90287-X","article-title":"An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop","volume":"70","author":"Lehr","year":"1991","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0320","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.addr.2005.07.001","article-title":"The basics and underlying mechanisms of mucoadhesion","volume":"57","author":"Smart","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0325","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.reactfunctpolym.2013.04.008","article-title":"Thiomer: A potential carrier for therapeutic delivery","volume":"73","author":"Kumar","year":"2013","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.addr.2016.06.005_bb0330","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ddtec.2005.05.001","article-title":"Mucoadhesive systems in oral drug delivery","volume":"2","author":"Bernkop-Schnurch","year":"2005","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.addr.2016.06.005_bb0335","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1002\/jps.24102","article-title":"In vivo evaluation of thiolated chitosan tablets for oral insulin delivery","volume":"103","author":"Millotti","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0340","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1023\/A:1020416918624","article-title":"Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers","volume":"19","author":"Dorkoosh","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0345","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jconrel.2004.06.012","article-title":"Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy","volume":"99","author":"Dorkoosh","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0350","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1208\/s12248-014-9634-3","article-title":"Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative","volume":"16","author":"Brayden","year":"2014","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2016.06.005_bb0355","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1271\/bbb.63.680","article-title":"Recovery of Caco-2 cell monolayers to normal from the transport-enhanced state induced by capric acid sodium salt and its monoacylglycerol","volume":"63","author":"Shima","year":"1999","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2016.06.005_bb0360","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1517\/17425247.3.5.685","article-title":"Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET","volume":"3","author":"Leonard","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0365","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0022-3565(25)38218-2","article-title":"In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa","volume":"265","author":"Lecluyse","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0370","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5173(98)00288-9","article-title":"The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations","volume":"176","author":"Baluom","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0375","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11095-007-9509-8","article-title":"Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer","volume":"25","author":"Narkar","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0380","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1023\/A:1026449527891","article-title":"Synchronized release of sulpiride and sodium decanoate from HPMC matrices: a rational approach to enhance sulpiride absorption in the rat intestine","volume":"17","author":"Baluom","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0385","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1023\/A:1011092613951","article-title":"Intestinal absorption of octreotide using trimethyl chitosan chloride: studies in pigs","volume":"18","author":"Thanou","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0390","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0169-409X(96)00491-7","article-title":"Solubilisation of hydrophilic drugs in oily formulations","volume":"25","author":"New","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0395","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1023\/A:1016043715791","article-title":"Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2\u20135 solutions","volume":"13","author":"Strickley","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0400","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3109\/03639045.2012.693503","article-title":"A study of the chemical and biological stability of vasoactive intestinal peptide","volume":"39","author":"Cui","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0405","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1208\/s12248-014-9688-2","article-title":"Physicochemical and formulation developability assessment for therapeutic peptide delivery\u2014a primer","volume":"17","author":"Bak","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2016.06.005_bb0410","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/A:1018819012405","article-title":"Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin (sCT)","volume":"16","author":"Sinko","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0415","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1023\/A:1012112219578","article-title":"Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate","volume":"14","author":"Lindmark","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0420","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ijpharm.2013.05.043","article-title":"Film coatings for oral colon delivery","volume":"457","author":"Maroni","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0425","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-3659(96)01582-9","article-title":"The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools","volume":"46","author":"Rubinstein","year":"1997","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0430","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2004.12.017","article-title":"Improvement of absorption enhancing effects of n-dodecyl-beta-d-maltopyranoside by its colon-specific delivery using chitosan capsules","volume":"293","author":"Fetih","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0435","first-page":"G965","article-title":"Ethanol modulation of intestinal epithelial tight junction barrier","volume":"276","author":"Ma","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0440","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1248\/bpb.17.753","article-title":"Comparison of absorption-enhancing effect between sodium caprate and disodium ethylenediaminetetraacetate in Caco-2 cells","volume":"17","author":"Tomita","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb0445","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.addr.2009.09.006","article-title":"Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic","volume":"61","author":"Maher","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0450","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1476-5381.1996.tb15177.x","article-title":"Permeation enhancement of octreotide by specific bile salts in rats and human subjects: in vitro, in vivo correlations","volume":"117","author":"Fricker","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0455","doi-asserted-by":"crossref","first-page":"G927","DOI":"10.1152\/ajpgi.00236.2012","article-title":"Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1","volume":"303","author":"Fukui","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb0460","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0169-409X(01)00231-9","article-title":"Oral drug absorption enhancement by chitosan and its derivatives","volume":"52","author":"Thanou","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0465","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1124\/mol.104.008375","article-title":"A novel strategy for the enhancement of drug absorption using a claudin modulator","volume":"67","author":"Kondoh","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0470","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/190263a0","article-title":"Gastro-intestinal absorption of heparin and synthetic heparinoids","volume":"190","author":"Windsor","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.addr.2016.06.005_bb0475","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0002-9343(64)90197-4","article-title":"An investigation of routes of administration of heparin other than injection","volume":"37","author":"Windsor","year":"1964","journal-title":"Am. J. Med."},{"key":"10.1016\/j.addr.2016.06.005_bb0480","doi-asserted-by":"crossref","first-page":"C854","DOI":"10.1152\/ajpcell.1987.253.6.C854","article-title":"Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction","volume":"253","author":"Madara","year":"1987","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0485","first-page":"G416","article-title":"Functional coupling of tight junctions and microfilaments in T84 monolayers","volume":"254","author":"Madara","year":"1988","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0490","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI119271","article-title":"Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model","volume":"99","author":"Fasano","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb0495","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0022-3565(24)29666-X","article-title":"Modulation of intestinal permeability by nitric oxide donors: implications in intestinal delivery of poorly absorbable drugs","volume":"296","author":"Yamamoto","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0500","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1023\/A:1011094025008","article-title":"Improving the selectivity of HAV-peptides in modulating E-cadherin-E-cadherin interactions in the intercellular junction of MDCK cell monolayers","volume":"18","author":"Makagiansar","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0505","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1124\/mol.64.6.1530","article-title":"A new principle for tight junction modulation based on occludin peptides","volume":"64","author":"Tavelin","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0510","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.147.1.195","article-title":"Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: evidence for direct involvement of claudins in tight junction barrier","volume":"147","author":"Sonoda","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb0515","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2174\/187221108784534117","article-title":"Inventions designed to enhance drug delivery across epithelial and endothelial cells through the paracellular pathway","volume":"2","author":"Gonzalez-Mariscal","year":"2008","journal-title":"Recent Pat. Drug Deliv. Formul."},{"key":"10.1016\/j.addr.2016.06.005_bb0520","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.addr.2003.10.045","article-title":"Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins","volume":"56","author":"Fasano","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0525","series-title":"Physiology of the Gastrointestinal Tract (Fourth Edition)","first-page":"1559","article-title":"CHAPTER 61 \u2014 Tight Junctions and the Intestinal Barrier","author":"Ma","year":"2006"},{"key":"10.1016\/j.addr.2016.06.005_bb0530","unstructured":"University of Maryland at Baltimore US5665389 (1997)."},{"key":"10.1016\/j.addr.2016.06.005_bb0535","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0540","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.peptides.2012.02.016","article-title":"Larazotide acetate promotes tight junction assembly in epithelial cells","volume":"35","author":"Gopalakrishnan","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.addr.2016.06.005_bb0545","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/apt.12147","article-title":"Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study","volume":"37","author":"Kelly","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0550","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/ajg.2012.211","article-title":"A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge","volume":"107","author":"Leffler","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.addr.2016.06.005_bb0555","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpharm.2008.08.047","article-title":"Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer","volume":"365","author":"Gopalakrishnan","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0560","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijpharm.2009.12.022","article-title":"Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin","volume":"387","author":"Maher","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0565","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1172\/JCI118114","article-title":"Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro","volume":"96","author":"Fasano","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb0570","doi-asserted-by":"crossref","first-page":"19160","DOI":"10.1074\/jbc.M009674200","article-title":"Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain","volume":"276","author":"Di Pierro","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb0575","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijpharm.2007.09.011","article-title":"Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A","volume":"351","author":"Song","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0580","doi-asserted-by":"crossref","first-page":"6944","DOI":"10.1073\/pnas.86.18.6944","article-title":"Melittin binding causes a large calcium-dependent conformational change in calmodulin","volume":"86","author":"Kataoka","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2016.06.005_bb0585","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.bcp.2006.01.012","article-title":"Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro","volume":"71","author":"Maher","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0590","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ejps.2009.07.011","article-title":"Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies","volume":"38","author":"Maher","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0595","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejps.2009.09.001","article-title":"Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae","volume":"38","author":"Maher","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0600","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1242\/jcs.01425","article-title":"The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells","volume":"117","author":"Nava","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0605","unstructured":"Mariscal-Gonzalez L, Nava-Dominguez, P. US2006\/0251663 (2006)."},{"key":"10.1016\/j.addr.2016.06.005_bb0610","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.3390\/toxins2061336","article-title":"On the interaction of Clostridium perfringens enterotoxin with claudins","volume":"2","author":"Veshnyakova","year":"2010","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.addr.2016.06.005_bb0615","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2353\/ajpath.2008.070698","article-title":"A key claudin extracellular loop domain is critical for epithelial barrier integrity","volume":"172","author":"Mrsny","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2016.06.005_bb0620","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biomaterials.2015.03.007","article-title":"Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers","volume":"54","author":"Staat","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2016.06.005_bb0625","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1126\/science.1261833","article-title":"Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin","volume":"347","author":"Saitoh","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.addr.2016.06.005_bb0630","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.bcp.2010.01.010","article-title":"A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide","volume":"79","author":"Uchida","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0635","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1016\/j.biomaterials.2012.01.017","article-title":"Creation and biochemical analysis of a broad-specific claudin binder","volume":"33","author":"Takahashi","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2016.06.005_bb0640","first-page":"G467","article-title":"Tight junctions and the molecular basis for regulation of paracellular permeability","volume":"269","author":"Anderson","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0645","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0022-3565(24)37216-7","article-title":"Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells","volume":"284","author":"Lindmark","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb0650","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2133\/dmpk.22.67","article-title":"Mechanistic analysis for drug permeation through intestinal membrane","volume":"22","author":"Hayashi","year":"2007","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.addr.2016.06.005_bb0655","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0167-4889(94)90163-5","article-title":"Paracellular barrier and junctional protein distribution depend on basolateral extracellular Ca2+ in cultured epithelia","volume":"1222","author":"Collares-Buzato","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0660","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-5173(93)90195-L","article-title":"Cell-polarity dependent effect of chelation on the paracellular permeability of confluent caco-2 cell monolayers","volume":"90","author":"Noach","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0665","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jps.2600790710","article-title":"Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells","volume":"79","author":"Artursson","year":"1990","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0670","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.cellbio.13.1.119","article-title":"Molecular and functional analysis of cadherin-based adherens junctions","volume":"13","author":"Yap","year":"1997","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb0675","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/1097-0029(20001015)51:2<156::AID-JEMT7>3.0.CO;2-J","article-title":"Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: role of cytoskeletal involvement","volume":"51","author":"Ma","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.addr.2016.06.005_bb0680","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1021\/js9504604","article-title":"Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells","volume":"85","author":"Tomita","year":"1996","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0685","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bbamem.2007.08.018","article-title":"Crosstalk of tight junction components with signaling pathways","volume":"1778","author":"Gonzalez-Mariscal","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0690","doi-asserted-by":"crossref","first-page":"C554","DOI":"10.1152\/ajpcell.1999.277.3.C554","article-title":"PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase","volume":"277","author":"Turner","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0695","unstructured":"Oramed Ltd. US20110014247 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb0700","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1463-1326.2009.01153.x","article-title":"Open-label study to assess the safety and pharmacodynamics of five oral insulin formulations in healthy subjects","volume":"12","author":"Eldor","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.addr.2016.06.005_bb0705","series-title":"WO 2002034880","author":"University of Kansas","year":"2002"},{"key":"10.1016\/j.addr.2016.06.005_bb0710","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1083\/jcb.136.2.399","article-title":"A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier","volume":"136","author":"Wong","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb0715","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/scdb.2000.0180","article-title":"\u2018Putting the squeeze\u2019 on the tight junction: understanding cytoskeletal regulation","volume":"11","author":"Turner","year":"2000","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb0720","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/labinvest.3700373","article-title":"Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease","volume":"86","author":"Blair","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb0725","doi-asserted-by":"crossref","first-page":"G875","DOI":"10.1152\/ajpgi.2000.279.5.G875","article-title":"Cytochalasin B modulation of Caco-2 tight junction barrier: role of myosin light chain kinase","volume":"279","author":"Ma","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb0730","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s11095-007-9527-6","article-title":"Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro","volume":"25","author":"Feighery","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0735","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2015.05.270","article-title":"Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation","volume":"210","author":"Taverner","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0740","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/BF02915334","article-title":"A classification of biologic lipids based upon their interaction in aqeous systems","volume":"45","author":"Small","year":"1968","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.addr.2016.06.005_bb0745","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejpb.2015.05.013","article-title":"Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol","volume":"94","author":"Brayden","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0750","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ejpb.2014.10.008","article-title":"A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells","volume":"88","author":"Brayden","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0755","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-4157(75)90016-7","article-title":"Solubilization of membranes by detergents","volume":"415","author":"Helenius","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0760","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0304-4157(83)90004-7","article-title":"Solubilization of phospholipids by detergents. Structural and kinetic aspects","volume":"737","author":"Lichtenberg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0765","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5173(98)00345-7","article-title":"Surfactants in membrane solubilisation","volume":"177","author":"Jones","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0770","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jcis.2013.06.019","article-title":"Adsorption of sodium hexanoate on alpha-alumina","volume":"407","author":"Lee","year":"2013","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0775","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3402\/tellusb.v60i3.16935","article-title":"Surfactant partitioning in cloud droplet activation: a study of C8, C10, C12 and C14 normal fatty acid sodium salts","volume":"60","author":"Prisle","year":"2008","journal-title":"Tellus B"},{"key":"10.1016\/j.addr.2016.06.005_bb0780","first-page":"1","article-title":"Environmental Risk Assessment on ingredients of European household cleaning products","author":"Human health risk assessment","year":"2012","journal-title":"Fat. Acid Salts"},{"key":"10.1016\/j.addr.2016.06.005_bb0785","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.colsurfb.2007.01.009","article-title":"Micellization of bile salts in aqueous medium: a fluorescence study","volume":"57","author":"Subuddhi","year":"2007","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2016.06.005_bb0790","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.farmac.2005.08.008","article-title":"Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers","volume":"60","author":"Sharma","year":"2005","journal-title":"Farmaco"},{"key":"10.1016\/j.addr.2016.06.005_bb0795","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/mp500776a","article-title":"Interaction with mixed micelles in the intestine attenuates the permeation enhancing potential of alkyl-maltosides","volume":"12","author":"Gradauer","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0800","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrd2197","article-title":"Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs","volume":"6","author":"Porter","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2016.06.005_bb0805","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1248\/bpb.27.418","article-title":"Studies on the intestinal absorption of low molecular weight heparin using saturated fatty acids and their derivatives as an absorption enhancer in rats","volume":"27","author":"Mori","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb0810","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1023\/A:1018909210879","article-title":"Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route","volume":"10","author":"Anderberg","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0815","first-page":"3270","article-title":"Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans","volume":"56","author":"Govers","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0820","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jconrel.2013.05.002","article-title":"A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine","volume":"172","author":"Gupta","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb0825","series-title":"Biological Implications Of Surfactant Presence In Formulations, Surfactant Systems","first-page":"388","author":"Attwood","year":"1983"},{"key":"10.1016\/j.addr.2016.06.005_bb0830","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1248\/cpb.33.282","article-title":"Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of beta-lactam antibiotics in rats","volume":"33","author":"Nishimura","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb0835","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1152\/physiol.00032.2006","article-title":"Lipid rafts, detergent-resistant membranes, and raft targeting signals","volume":"21","author":"Brown","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.addr.2016.06.005_bb0840","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.1983.tb31672.x","article-title":"Modification of cell membrane composition by dietary lipids and its implications for atherosclerosis","volume":"414","author":"Kummerow","year":"1983","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0845","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1021\/bi00579a022","article-title":"Studies on the molecular packing of mixed dispersions of Triton X-100 and sphingomyelin and its dependence on temperature and cloud point","volume":"18","author":"Lichtenberg","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2016.06.005_bb0850","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0304-4157(80)90006-4","article-title":"Sphingomyelins in bilayers and biological membranes","volume":"604","author":"Barenholz","year":"1980","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb0855","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/bi00122a017","article-title":"Structure and cohesive properties of sphingomyelin\/cholesterol bilayers","volume":"31","author":"McIntosh","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2016.06.005_bb0860","series-title":"Phospholipids","first-page":"129","article-title":"Sphingomyelin: metabolism, chemical synthesis, chemical and physical properties","author":"Barenholz","year":"1982"},{"key":"10.1016\/j.addr.2016.06.005_bb0865","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.colsurfb.2006.01.001","article-title":"Kinetic studies of the interaction of fatty acids with phosphatidylcholine vesicles (liposomes)","volume":"48","author":"Rogerson","year":"2006","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2016.06.005_bb0870","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1021\/bi00262a010","article-title":"Solubilization of phosphatidylcholine bilayers by octyl glucoside","volume":"21","author":"Jackson","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2016.06.005_bb0875","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1021\/bi00583a013","article-title":"Structural and kinetic studies on the solubilization of lecithin by sodium deoxycholate","volume":"18","author":"Lichtenberg","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2016.06.005_bb0880","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1023\/A:1015854127486","article-title":"Differences in the enhancing effects of sodium caprate on colonic and jejunal drug absorption","volume":"9","author":"Tomita","year":"1992","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0885","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1023\/A:1015992819290","article-title":"Enhancement of colonic drug absorption by the transcellular permeation route","volume":"5","author":"Tomita","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0890","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0003-9861(74)90305-1","article-title":"Formation and characterization of mixed micelles of the nonionic surfactant Triton X-100 with egg, dipalmitoyl, and dimyristoyl phosphatidylcholines","volume":"165","author":"Dennis","year":"1974","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.addr.2016.06.005_bb0895","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1023\/A:1015840921203","article-title":"Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate","volume":"8","author":"Sawada","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0900","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/jps.20051","article-title":"Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate","volume":"93","author":"Raoof","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0905","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.4155\/tde.11.132","article-title":"Oral delivery of macromolecules: rationale underpinning Gastrointestinal Permeation Enhancement Technology (GIPET)","volume":"2","author":"Walsh","year":"2011","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb0910","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00280-009-1038-1","article-title":"Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics","volume":"64","author":"Amory","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0915","series-title":"WO20000050012","author":"Cumming","year":"2000"},{"key":"10.1016\/j.addr.2016.06.005_bb0920","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1211\/0022357991776976","article-title":"Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-d-maltopyranoside","volume":"51","author":"Uchiyama","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb0925","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3109\/03639049309062992","article-title":"The effects of fatty acids and their derivatives on the intestinal absorption of insulin in rat","volume":"19","author":"Muranushi","year":"1993","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0930","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0928-0987(02)00162-8","article-title":"Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs","volume":"17","author":"Raoof","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0935","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jps.21084","article-title":"Oral delivery of antisense oligonucleotides in man","volume":"97","author":"Tillman","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0940","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1023\/A:1016289200422","article-title":"The effect of absorption enhancers on the oral absorption of the GP IIB\/IIIA receptor antagonist, DMP 728, in rats and dogs","volume":"12","author":"Burcham","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0945","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0021-9797(70)90215-8","article-title":"Some micellar properties of long-chain acylcarnitines","volume":"34","author":"Yalkowsky","year":"1970","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb0950","first-page":"G332","article-title":"Acylcarnitines: drug absorption-enhancing agents in the gastrointestinal tract","volume":"251","author":"Fix","year":"1986","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb0955","author":"Enteris BioPharma"},{"key":"10.1016\/j.addr.2016.06.005_bb0960","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/jbmr.1602","article-title":"A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial","volume":"27","author":"Binkley","year":"2012","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0965","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s40262-013-0083-4","article-title":"Pharmacokinetics of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis","volume":"52","author":"Sturmer","year":"2013","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2016.06.005_bb0970","unstructured":"Unigene Laboratories Ltd. US6086918 (2000)."},{"key":"10.1016\/j.addr.2016.06.005_bb0975","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ijpharm.2013.04.034","article-title":"Food, physiology and drug delivery","volume":"457","author":"Varum","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb0980","unstructured":"Unigene Laboratories Ltd. US5912014 (1999)."},{"key":"10.1016\/j.addr.2016.06.005_bb0985","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0169-409X(00)00063-6","article-title":"Oral delivery of salmon calcitonin","volume":"42","author":"Lee","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb0990","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1023\/A:1014849630520","article-title":"Impact of regional intestinal pH modulation on absorption of peptide drugs: oral absorption studies of salmon calcitonin in beagle dogs","volume":"16","author":"Lee","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb0995","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0939-6411(00)00102-8","article-title":"Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs","volume":"50","author":"Hee Lee","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1000","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s00198-014-2796-0","article-title":"Efficacy and safety of oral recombinant calcitonin tablets in postmenopausal women with low bone mass and increased fracture risk: a randomized, placebo-controlled trial","volume":"25","author":"Binkley","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.addr.2016.06.005_bb1005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3109\/03639040903173580","article-title":"Evaluation of salmon calcitonin (sCT) enteric-coated capsule for enhanced absorption and GI tolerability in rats","volume":"36","author":"Wu","year":"2010","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1010","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0168-3659(99)00031-0","article-title":"Physiological mechanism for enhancement of paracellular drug transport","volume":"62","author":"Hayashi","year":"1999","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1015","first-page":"4","article-title":"Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract","volume":"271","author":"Guarini","year":"1984","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb1020","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1351\/pac198153112057","article-title":"Surfactant interactions with biomembranes and drug absorption","author":"Florence","year":"1981","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.2042-7158.1981.tb13759.x","article-title":"Non-ionic surfactants and gastric mucosal transport of paraquat1","volume":"33","author":"Walters","year":"1981","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1030","first-page":"1","article-title":"Absorption enhancers","volume":"7","author":"Muranishi","year":"1990","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2016.06.005_bb1035","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.addr.2007.09.006","article-title":"Approaches for the development of solid and semi-solid lipid-based formulations","volume":"60","author":"Jannin","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb1040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1015930821648","article-title":"Site dependence of absorption-promoting actions of laureth-9, Na salicylate, Na2EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery","volume":"5","author":"Aungst","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1045","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.2042-7158.1987.tb03124.x","article-title":"Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat","volume":"39","author":"Ishizawa","year":"1987","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1050","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.2042-7158.1978.tb13402.x","article-title":"Increased intestinal absorption of insulin: an insulin suppository","volume":"30","author":"Shichiri","year":"1978","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1055","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1248\/bpb.24.1294","article-title":"Relative hypoglycemic effect of insulin suppositories in diabetic beagle dogs: optimization of various concentrations of sodium salicylate and polyoxyethylene-9-lauryl ether","volume":"24","author":"Hosny","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb1060","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.2042-7158.1985.tb04963.x","article-title":"Effect of non-ionic surfactants in a polyacrylic acid gel base on the rectal absorption of [Asu1,7]-eel calcitonin in rats","volume":"37","author":"Morimoto","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1065","series-title":"Introduction to Protein Purification, Protein Purification","first-page":"1","author":"Ersson","year":"2011"},{"key":"10.1016\/j.addr.2016.06.005_bb1070","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1023\/A:1018920728800","article-title":"Intestinal permeability enhancement: structure\u2013activity and structure\u2013toxicity relationships for nonylphenoxypolyoxyethylene surfactant permeability enhancers","volume":"11","author":"Swenson","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHAM.0000016235.32639.23","article-title":"Solubilizing excipients in oral and injectable formulations","volume":"21","author":"Strickley","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1080","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jps.2600810908","article-title":"Epithelial transport of drugs in cell culture. VII: effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells","volume":"81","author":"Anderberg","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1211\/0022357001773805","article-title":"Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells","volume":"52","author":"Dimitrijevic","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1090","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1248\/cpb.31.3255","article-title":"Effect of pharmaceutical adjuvants on the rectal permeability of drugs. II. Effect of Tween-type surfactants on the permeability of drugs in the rat rectum","volume":"31","author":"Nakanishi","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb1095","first-page":"353","article-title":"Investigation of physical and hypoglycaemic properties of rectal suppositories with chosen insulin","volume":"59","author":"Kosior","year":"2002","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2012.04.076","article-title":"Sucrose esters as natural surfactants in drug delivery systems\u2014a mini-review","volume":"433","author":"Szuts","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1248\/yakushi.13-00221-1","article-title":"Improvement of intestinal absorption of poorly absorbable drugs by various sugar esters","volume":"134","author":"Yamamoto","year":"2014","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.addr.2016.06.005_bb1110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2174\/156720112802650699","article-title":"Enhancement potential of sucrose laurate (L-1695) on intestinal absorption of water-soluble high molecular weight compounds","volume":"9","author":"Onishi","year":"2012","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb1115","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.actbio.2010.01.044","article-title":"Sucrose esters with various hydrophilic\u2013lipophilic properties: novel controlled release agents for oral drug delivery matrix tablets prepared by direct compaction","volume":"6","author":"Chansanroj","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2016.06.005_bb1120","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-5173(92)90107-D","article-title":"Assessment of enhancing ability of medium-chain alkyl saccharides as new absorption enhancers in rat rectum","volume":"79","author":"Masahiro","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1125","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0378-5173(94)90105-8","article-title":"Site-dependence and structure\u2013effect relationships for alkylglycosides as transmucosal absorption promoters for insulin","volume":"105","author":"Aungst","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1130","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1517\/17425247.3.4.529","article-title":"Intravail: highly effective intranasal delivery of peptide and protein drugs","volume":"3","author":"Maggio","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb1135","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejps.2012.08.010","article-title":"Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers","volume":"47","author":"Petersen","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1140","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.ejps.2013.01.009","article-title":"Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer","volume":"48","author":"Petersen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijpharm.2005.09.028","article-title":"Effects of absorption promoters on insulin absorption through colon-targeted delivery","volume":"307","author":"Katsuma","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0168-3659(92)90068-3","article-title":"Insulin stabilization and GI absorption","volume":"19","author":"Hovgaard","year":"1992","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1155","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1248\/bpb.22.611","article-title":"Development of an oral formulation of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, using n-lauryl-beta-d-maltopyranoside as an absorption enhancer","volume":"22","author":"Sasaki","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb1160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.regpep.2011.02.009","article-title":"Oral delivery of octreotide acetate in Intravail(R) improves uptake, half-life, and bioavailability over subcutaneous administration in male Swiss webster mice","volume":"167","author":"Maggio","year":"2011","journal-title":"Regul. Pept."},{"key":"10.1016\/j.addr.2016.06.005_bb1165","unstructured":"Aegis Therapeutics Llc. US20130034597 (2013)."},{"key":"10.1016\/j.addr.2016.06.005_bb1170","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.regpep.2009.12.008","article-title":"Oral delivery of mouse [d-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, in male Swiss Webster mice: a study comparing the pharmacokinetics of oral delivery to intraperitoneal, subcutaneous, intramuscular, and intranasal administration","volume":"160","author":"Lee","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.addr.2016.06.005_bb1175","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/apt.13333","article-title":"Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?","volume":"42","author":"Pavlidis","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb1180","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3748\/wjg.15.804","article-title":"Bile acids: chemistry, physiology, and pathophysiology","volume":"15","author":"Monte","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2016.06.005_bb1185","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0378-5173(94)00117-0","article-title":"Effects of bile salts on brush-border and cytosolic proteolytic activities of intestinal enterocytes","volume":"111","author":"Bai","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1190","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0006-2952(83)90575-0","article-title":"Bile salts facilitate the absorption of heparin from the intestine","volume":"32","author":"Ziv","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1195","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0378-5173(94)90082-5","article-title":"Enhancement of human calcitonin absorption across the rat colon in vivo","volume":"101","author":"Hastewella","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1200","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0024-3205(81)90036-9","article-title":"Bile salts promote the absorption of insulin from the rat colon","volume":"29","author":"Ziv","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1205","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0378-5173(95)04395-0","article-title":"Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergistic effects of acylation and absorption enhancers","volume":"134","author":"Fujita","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0928-0987(99)00092-5","article-title":"Evaluation of absorption enhancement for a potent cyclopeptidic alpha(nu)beta(3)-antagonist in a human intestinal cell line (Caco-2)","volume":"10","author":"Kamm","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1215","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF02976964","article-title":"Effect of excipients on the stability and transport of recombinant human epidermal growth factor (rhEGF) across Caco-2 cell monolayers","volume":"26","author":"Kim","year":"2003","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0378-5173(85)90148-6","article-title":"Colorectal administration of human interferon-\u03b1","volume":"24","author":"Bocci","year":"1985","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1225","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.2042-7158.1997.tb06041.x","article-title":"Effects of different absorption enhancers on the permeation of ebiratide, an ACTH analogue, across intestinal membranes","volume":"49","author":"Yamamoto","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1230","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.2042-7158.1992.tb05466.x","article-title":"Effects of salicylate and other enhancers on rectal absorption of erythropoietin in rats","volume":"44","author":"Mizuno","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1235","unstructured":"Generex Pharmaceutical Inc. US7255102 (2007)."},{"key":"10.1016\/j.addr.2016.06.005_bb1240","unstructured":"Biocon Ltd. US7196059 (2007)."},{"key":"10.1016\/j.addr.2016.06.005_bb1245","unstructured":"Aegis Therapeutics Llc. US7998927B2 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb1250","unstructured":"William L, Lu F. US20120128767 (2012)."},{"key":"10.1016\/j.addr.2016.06.005_bb1255","first-page":"173","article-title":"Rectal administration of insulin","volume":"20","author":"Raz","year":"1984","journal-title":"Isr. J. Med. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1260","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1463-1326.2010.01213.x","article-title":"A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects","volume":"12","author":"Khedkar","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.addr.2016.06.005_bb1265","unstructured":"Biocon Ltd. US2010\/0285143 (2010)."},{"key":"10.1016\/j.addr.2016.06.005_bb1270","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jps.2600651011","article-title":"Interaction of sodium alkyl sulfates with everted rat small intestinal membrane","volume":"65","author":"Feldman","year":"1976","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1275","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/jps.2600820412","article-title":"Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells","volume":"82","author":"Anderberg","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1280","doi-asserted-by":"crossref","unstructured":"T. Hargreaves, Surfactants in Action, in: T. Hargreaves (Ed.) In: Chemical Formulation: An Overview of Surfactant Based Chemical Preparations Used in Everyday Life, The Royal Society of Chemistry 2003, pp. P007-P012.","DOI":"10.1039\/9781847550385-00048"},{"key":"10.1016\/j.addr.2016.06.005_bb1285","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1271\/bbb.62.83","article-title":"The relationship between transport-enhancement effects and cell viability by capric acid sodium salt, monocaprin, and dicaproin","volume":"62","author":"Shima","year":"1998","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2016.06.005_bb1290","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1248\/bpb1978.9.532","article-title":"Effect of medium-chain glycerides (MGK) on the intestinal absorption and the hepatobiliary transport of bromthymol blue","volume":"9","author":"Higaki","year":"1986","journal-title":"J. Pharmacobiodyn."},{"issue":"Suppl. 2","key":"10.1016\/j.addr.2016.06.005_bb1295","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/S0928-0987(00)00167-6","article-title":"Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and \u2018self-microemulsifying\u2019 drug delivery systems","volume":"11","author":"Pouton","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1300","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1021\/mp8001667","article-title":"Structure and dynamics of glyceride lipid formulations, with propylene glycol and water","volume":"6","author":"Warren","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1305","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0378-5173(94)00272-7","article-title":"Particle size determination of phase-inverted water-in-oil microemulsions under different dilution and storage conditions","volume":"115","author":"Constantinides","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1310","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1211\/0022357044175","article-title":"Oil-based formulations for oral delivery of insulin","volume":"56","author":"Li","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1315","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejps.2010.01.006","article-title":"Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery","volume":"39","author":"Wang","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1320","series-title":"EP1460992B1","author":"Dor Biopharm Inc.","year":"2009"},{"key":"10.1016\/j.addr.2016.06.005_bb1325","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0169-409X(97)00073-2","article-title":"Absorption-promoting adjuvants: enhancing action on rectal absorption","volume":"28","author":"Nishihata","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb1330","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1248\/bpb1978.7.856","article-title":"Improvement of bioavailability of poorly absorbed drugs. I. Effect of medium chain glyceride base on the rectal absorption of cefmetazole sodium in rats","volume":"7","author":"Sekine","year":"1984","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb1335","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jps.2600771007","article-title":"Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats","volume":"77","author":"Watanabe","year":"1988","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1340","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejps.2006.04.016","article-title":"Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system","volume":"29","author":"Pouton","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1345","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11095-011-0541-3","article-title":"A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid\/surfactant\/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development","volume":"29","author":"Prajapati","year":"2012","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1350","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1248\/bpb1978.8.286","article-title":"Improvement of bioavailability of poorly absorbed drugs. II. Effect of medium chain glyceride base on the intestinal absorption of cefmetazole sodium in rats and dogs","volume":"8","author":"Sekine","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb1355","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1015864022305","article-title":"Rectal absorption enhancement of des-enkephalin-gamma-endorphin (DE gamma E) by medium-chain glycerides and EDTA in conscious rats","volume":"6","author":"van Hoogdalem","year":"1989","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1360","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1248\/bpb1978.8.645","article-title":"Improvement of bioavailability of poorly absorbed drugs. IV. Mechanism of the promoting effect of medium chain glyceride on the rectal absorption of water soluble drugs","volume":"8","author":"Sekine","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb1365","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1248\/bpb1978.13.591","article-title":"Duration of absorption-enhancing effect of sodium octanoate, sodium hexanoate or glyceryl-1-monooctanoate on rectal absorption of gentamicin in rabbits","volume":"13","author":"Matsumoto","year":"1990","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb1370","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.2042-7158.1987.tb03123.x","article-title":"Effect of triglyceride on small intestinal absorption of cefoxitin in rats","volume":"39","author":"Yoshitomi","year":"1987","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1375","series-title":"Oral Lipid-Based Formulations: Enhancing The Bioavailability Of Poorly Water-Soluble Drugs","article-title":"Currently Marketed Oral Lipid Based Dosage Forms: Drug Products And Excipients","author":"RG","year":"2007"},{"key":"10.1016\/j.addr.2016.06.005_bb1380","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v16.i5.20","article-title":"Microemulsions: an overview and pharmaceutical applications","volume":"16","author":"Tenjarla","year":"1999","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2016.06.005_bb1385","series-title":"Currently Marketed Oral Lipid-Based Dosage Forms, Oral Lipid-Based Formulations","first-page":"1","author":"Robert","year":"2007"},{"key":"10.1016\/j.addr.2016.06.005_bb1390","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0001-8686(98)00063-3","article-title":"Structure, dynamics and transport properties of microemulsions","volume":"78","author":"Moulik","year":"1998","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1395","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijpharm.2003.11.013","article-title":"In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer","volume":"271","author":"Rama Prasad","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1400","series-title":"Enhancement in Drug Delivery","first-page":"37","article-title":"Enhancers For Enteral Delivery Of Macromolecules With Emphasis On Surfactants","author":"Godin","year":"2011"},{"key":"10.1016\/j.addr.2016.06.005_bb1405","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1023\/A:1016033702220","article-title":"The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system","volume":"13","author":"Nerurkar","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1410","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0168-3659(96)01353-3","article-title":"Enhancement of the intestinal absorption of peptides and nonpeptides","volume":"41","author":"Aungst","year":"1996","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1415","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ejps.2005.01.001","article-title":"Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells","volume":"24","author":"Sha","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1420","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2005.11.009","article-title":"Gastro-intestinal patch system for the delivery of erythropoietin","volume":"111","author":"Venkatesan","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1425","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijpharm.2009.06.018","article-title":"The effects of common solubilizing agents on the intestinal membrane barrier functions and membrane toxicity in rats","volume":"379","author":"Hamid","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1430","unstructured":"Novo Nordisk A\/S US20120196800 (2012)."},{"key":"10.1016\/j.addr.2016.06.005_bb1435","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/10611860290022688","article-title":"Absorption enhancing effect of labrasol on the intestinal absorption of insulin in rats","volume":"10","author":"Eaimtrakarn","year":"2002","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2016.06.005_bb1440","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.1016\/j.biomaterials.2005.05.012","article-title":"Liquid filled nanoparticles as a drug delivery tool for protein therapeutics","volume":"26","author":"Venkatesan","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2016.06.005_bb1445","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2006.02.056","article-title":"Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies","volume":"317","author":"Ito","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1450","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijpharm.2011.08.029","article-title":"Preliminary evaluation of a novel oral delivery system for rhPTH1-34: in vitro and in vivo","volume":"420","author":"Guo","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1455","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpb.2009.09.004","article-title":"Nano-sized water-in-oil-in-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound","volume":"74","author":"Koga","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1460","unstructured":"Novo Nordisk A\/S US2011\/0144010 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb1465","unstructured":"Novo Nordisk A\/S US2013\/0058999 (2013)."},{"key":"10.1016\/j.addr.2016.06.005_bb1470","unstructured":"Novo Nordisk A\/S US20110293714 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb1475","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejps.2015.09.001","article-title":"In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill(R)) of salmon calcitonin","volume":"79","author":"Aguirre","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1480","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-5173(97)00248-2","article-title":"Formulation and physical characterization of water-in-oil microemulsions containing long- versus medium-chain glycerides","volume":"158","author":"Constantinides","year":"1997","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1485","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/10717540500313109","article-title":"Lecithin-based microemulsion of a peptide for oral administration: preparation, characterization, and physical stability of the formulation","volume":"13","author":"Cilek","year":"2006","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb1490","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijpharm.2005.04.016","article-title":"A lecithin-based microemulsion of rh-insulin with aprotinin for oral administration: Investigation of hypoglycemic effects in non-diabetic and STZ-induced diabetic rats","volume":"298","author":"Cilek","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1495","first-page":"712","article-title":"Macrulin Cortecs Ltd","volume":"1","author":"Luo","year":"1998","journal-title":"IDrugs"},{"key":"10.1016\/j.addr.2016.06.005_bb1500","first-page":"199","article-title":"Development of a colonic release capsule dosage form and the absorption of insulin","volume":"14","author":"Kraeling","year":"1992","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1505","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejpb.2010.07.002","article-title":"Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats","volume":"76","author":"Sharma","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1510","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1021\/la00102a014","article-title":"Spontaneous formation of a water-continuous emulsion from a w\/o microemulsion","volume":"6","author":"Greiner","year":"1990","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2016.06.005_bb1515","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1520","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1208\/s12248-012-9441-7","article-title":"In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery","volume":"15","author":"Liu","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2016.06.005_bb1525","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0168-3659(94)00129-I","article-title":"Enhanced intestinal absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle size","volume":"34","author":"Constantinides","year":"1995","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1530","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1023\/A:1016030812272","article-title":"Water-in-oil microemulsions containing medium-chain fatty acids\/salts: formulation and intestinal absorption enhancement evaluation","volume":"13","author":"Constantinides","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1535","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/0-306-46803-4_7","article-title":"Multiple emulsions for the delivery of proteins","volume":"10","author":"Shively","year":"1997","journal-title":"Pharm. Biotechnol."},{"key":"10.1016\/j.addr.2016.06.005_bb1540","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/219856a0","article-title":"Insulin: intestinal absorption as water-in-oil-in-water emulsions","volume":"219","author":"Engel","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.addr.2016.06.005_bb1545","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF02627733","article-title":"Enteral absorption of water-in-oil-in-water insulin emulsions in rabbits","volume":"10","author":"Shichiri","year":"1974","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2016.06.005_bb1550","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1365-2710.2000.00306.x","article-title":"Oral multiple w\/o\/w emulsion formulation of a peptide salmon calcitonin: in vitro-in vivo evaluation","volume":"25","author":"Dogru","year":"2000","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb1555","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-5173(99)00119-2","article-title":"Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats","volume":"184","author":"Barichello","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1560","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF02581062","article-title":"Increased intestinal absorption of insulin in a micellar solution: water-in-oil-in-water insulin micelles","volume":"15","author":"Shichiri","year":"1978","journal-title":"Acta Diabetol. Lat."},{"key":"10.1016\/j.addr.2016.06.005_bb1565","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0378-5173(97)00249-4","article-title":"W\/O\/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: preparation, characterization and determination of stability towards proteases in vitro","volume":"158","author":"Silva-Cunha","year":"1997","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1570","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1021\/js980125q","article-title":"Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid","volume":"87","author":"Suzuki","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1575","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/BF02536028","article-title":"Evaluation of an oleic acid water-in-oil-in-water-type multiple emulsion as potential drug carrier via the enteral route","volume":"27","author":"Oba","year":"1992","journal-title":"Lipids"},{"key":"10.1016\/j.addr.2016.06.005_bb1580","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0378-5173(00)00411-7","article-title":"The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA","volume":"201","author":"Morishita","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1585","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2003.09.008","article-title":"Hydrolysis of the oil phase of a W\/O\/W emulsion by pancreatic lipase","volume":"94","author":"Shima","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1590","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.foodhyd.2005.05.002","article-title":"Oral administration of insulin included in fine W\/O\/W emulsions to rats","volume":"20","author":"Shima","year":"2006","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.addr.2016.06.005_bb1595","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00396-003-0960-8","article-title":"Improved formulation of W\/O\/W multiple emulsion for insulin encapsulation. Influence of the chemical structure of insulin","volume":"282","author":"Cournarie","year":"2004","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1600","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1248\/bpb.18.1718","article-title":"Absorption of insulin using water-in-oil-in-water emulsion from an enteral loop in rats","volume":"18","author":"Matsuzawa","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb1605","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejpb.2013.10.013","article-title":"Encapsulation of immunoglobulin G by solid-in-oil-in-water: effect of process parameters on microsphere properties","volume":"86","author":"Marquette","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1610","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-5173(02)00674-9","article-title":"Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S\/O\/W) emulsion","volume":"252","author":"Toorisaka","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1615","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2005.05.022","article-title":"An enteric-coated dry emulsion formulation for oral insulin delivery","volume":"107","author":"Toorisaka","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1620","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejpb.2009.06.004","article-title":"Formulation and characterization of an oily-based system for oral delivery of insulin","volume":"73","author":"Elsayed","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1625","series-title":"WO2005094785","author":"Ben-Sasson","year":"2005"},{"key":"10.1016\/j.addr.2016.06.005_bb1630","unstructured":"Salama P, Mamluk R, Marom K, Weinstein I, Tzabari M. US20120009229 (2012)."},{"key":"10.1016\/j.addr.2016.06.005_bb1635","unstructured":"Salama P, Karmeli I, Tuvia S, Marom K, Harush-Frenkel O, Gelbaum D, Mamluk R, Price FD, Peikin SR, US20110311621 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb1640","series-title":"WO2011116139","author":"Chiasma Inc.","year":"2011"},{"key":"10.1016\/j.addr.2016.06.005_bb1645","unstructured":"Salama P, Mamluk R, Marom K, Weinstein I, Tzabari M, US20100105627 (2010)."},{"key":"10.1016\/j.addr.2016.06.005_bb1650","unstructured":"Chiasma Inc., US8241670 (2012)."},{"key":"10.1016\/j.addr.2016.06.005_bb1655","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s11095-014-1303-9","article-title":"A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms","volume":"31","author":"Tuvia","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1660","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1210\/jc.2014-4113","article-title":"Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial","volume":"100","author":"Melmed","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2016.06.005_bb1665","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1023\/A:1015948720256","article-title":"Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration\u2013effect relationship","volume":"5","author":"van Hoogdalem","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1670","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2125.1989.tb05337.x","article-title":"Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers","volume":"27","author":"Van Hoogdalem","year":"1989","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1675","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/mp900319k","article-title":"Anticoagulant efficacy of solid oral formulations containing a new heparin derivative","volume":"7","author":"Park","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1680","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF01960074","article-title":"Ion pair absorption of ionized drugs\u2014fact or fiction?","volume":"5","author":"Jonkman","year":"1983","journal-title":"Pharm. Weekbl. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1685","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1021\/mp9002688","article-title":"Diabetes correction in pancreatectomized canines by orally absorbable insulin-deoxycholate complex","volume":"7","author":"Kim","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1690","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1073\/pnas.91.1.143","article-title":"Detergent-enabled transport of proteins and nucleic acids through hydrophobic solvents","volume":"91","author":"Bromberg","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2016.06.005_bb1695","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0005-2795(79)90088-6","article-title":"Precipitation of egg white proteins below their isoelectric points by sodium dodecyl sulphate and temperature","volume":"579","author":"Hegg","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb1700","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1023\/A:1011998014474","article-title":"Hydrophobic ion pairing: altering the solubility properties of biomolecules","volume":"15","author":"Meyer","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1705","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1016\/S0021-9258(18)62118-0","article-title":"The binding of detergents to proteins. I. The maximum amount of dodecyl sulfate bound to proteins and the resistance to binding of several proteins","volume":"246","author":"Nelson","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1710","series-title":"Critical Micelle Concentrations of Aqueous Surfactant Systems (National Bureau of Standards 36, Washington, D.C.)","author":"Mukerjee","year":"1971"},{"key":"10.1016\/j.addr.2016.06.005_bb1715","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/ja00057a006","article-title":"Structure and stability of insulin dissolved in 1-octanol","volume":"115","author":"Matsuura","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.addr.2016.06.005_bb1720","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1002\/jps.23640","article-title":"Preparation and characterization of insulin\u2013surfactant complexes for loading into lipid-based drug delivery systems","volume":"102","author":"Li","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1725","doi-asserted-by":"crossref","unstructured":"Mediplex Corp., US7906137 (2011).","DOI":"10.1016\/S1359-6128(11)70112-4"},{"key":"10.1016\/j.addr.2016.06.005_bb1730","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00125-004-1658-2","article-title":"A new drug carrier, Nalpha-deoxycholyl-l: -lysyl-methylester, for enhancing insulin absorption in the intestine","volume":"48","author":"Lee","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2016.06.005_bb1735","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1128\/AAC.50.5.1869-1871.2006","article-title":"Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats","volume":"50","author":"Lee","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2016.06.005_bb1740","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jconrel.2007.07.013","article-title":"Liphophilic complexation of heparin based on bile acid for oral delivery","volume":"123","author":"Lee","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1745","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1007\/s12272-013-0297-x","article-title":"Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats","volume":"37","author":"Park","year":"2014","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1750","first-page":"3049","article-title":"Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin","volume":"6","author":"Sun","year":"2011","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2016.06.005_bb1755","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2006.05.013","article-title":"Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation","volume":"114","author":"Cui","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1760","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijpharm.2015.04.075","article-title":"Reversible hydrophobic ion-paring complex strategy to minimize acylation of octreotide during long-term delivery from PLGA microparticles","volume":"489","author":"Vaishya","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1765","unstructured":"Emisphere Technologies Inc., US5401516 (1995)."},{"key":"10.1016\/j.addr.2016.06.005_bb1770","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1021\/jm00021a015","article-title":"N-acylated alpha-amino acids as novel oral delivery agents for proteins","volume":"38","author":"Leone-Bay","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1775","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1021\/jm00021a014","article-title":"Microsphere formation in a series of derivatized alpha-amino acids: properties, molecular modeling, and oral delivery of salmon calcitonin","volume":"38","author":"Leone-Bay","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1780","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/jm970811m","article-title":"Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin","volume":"41","author":"Leone-Bay","year":"1998","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.addr.2016.06.005_bb1785","first-page":"586","article-title":"Oral delivery of rhGH: preliminary mechanistic considerations","volume":"9","author":"Leone-Bay","year":"1996","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.addr.2016.06.005_bb1790","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1021\/jm960038f","article-title":"4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone","volume":"39","author":"Leone-Bay","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1795","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1023\/A:1016034913181","article-title":"Oral delivery of sodium cromolyn: preliminary studies in vivo and in vitro","volume":"13","author":"Leone-Bay","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1800","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1023\/A:1012192115828","article-title":"Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers","volume":"14","author":"Brayden","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1805","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1023\/A:1012160703533","article-title":"Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate: pharmacological considerations","volume":"14","author":"Rivera","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1810","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-3659(97)00101-6","article-title":"Acylated non-alpha-amino acids as novel agents for the oral delivery of heparin sodium, USP","volume":"50","author":"Leone-Bay","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb1815","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/1567201053586001","article-title":"Oral delivery of insulin with the eligen technology: mechanistic studies","volume":"2","author":"Malkov","year":"2005","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb1820","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejps.2005.03.003","article-title":"Investigation of the enhancing mechanism of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate effect on the intestinal permeability of polar molecules utilizing a voltage clamp method","volume":"25","author":"Hess","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb1825","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11095-007-9438-6","article-title":"Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative","volume":"25","author":"Alani","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1830","series-title":"WO 2000048589 A1","author":"Cumming","year":"2000"},{"key":"10.1016\/j.addr.2016.06.005_bb1840","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/1091581809337737","article-title":"Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague\u2013Dawley and Wistar rats","volume":"28","author":"Riley","year":"2009","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.addr.2016.06.005_bb1845","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1161\/01.CIR.98.16.1610","article-title":"Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans","volume":"98","author":"Baughman","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2016.06.005_bb1850","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1177\/0091270007307242","article-title":"Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects","volume":"47","author":"Mousa","year":"2007","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1855","author":"Emisphere Technologies Inc"},{"key":"10.1016\/j.addr.2016.06.005_bb1860","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3945\/ajcn.2010.29663","article-title":"Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects","volume":"92","author":"Steinert","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.addr.2016.06.005_bb1865","author":"Emisphere Technologies"},{"key":"10.1016\/j.addr.2016.06.005_bb1870","unstructured":"Oramed Ltd., US20110142800 (2011)."},{"key":"10.1016\/j.addr.2016.06.005_bb1875","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1464-5491.2004.01160.x","article-title":"A novel per-oral insulin formulation: proof of concept study in non-diabetic subjects","volume":"21","author":"Kidron","year":"2004","journal-title":"Diabet. Med."},{"key":"10.1016\/j.addr.2016.06.005_bb1880","doi-asserted-by":"crossref","DOI":"10.2337\/dc15-0165","article-title":"A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes","author":"Nauck","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.addr.2016.06.005_bb1885","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/acs.jmedchem.5b00726","article-title":"Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide","volume":"58","author":"Lau","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb1890","first-page":"227-227","article-title":"Oral GLP1 analogue rounds phase II corner","volume":"14","author":"Mullard","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2016.06.005_bb1895","unstructured":"Novo Nordisk A\/S US20130345134 A1 (2013)."},{"key":"10.1016\/j.addr.2016.06.005_bb1900","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1359\/JBMR.040715","article-title":"Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover","volume":"19","author":"Tanko","year":"2004","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1905","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.bone.2012.01.009","article-title":"The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women","volume":"50","author":"Hammerle","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.addr.2016.06.005_bb1910","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1023\/A:1014809916407","article-title":"Transcellular and lipophilic complex-enhanced intestinal absorption of human growth hormone","volume":"16","author":"Wu","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1915","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1472-6904-8-12","article-title":"Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin","volume":"8","author":"Karsdal","year":"2008","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1920","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.joca.2009.08.004","article-title":"The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study","volume":"18","author":"Karsdal","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.addr.2016.06.005_bb1925","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1472-6904-8-5","article-title":"Optimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon Calcitonin","volume":"8","author":"Karsdal","year":"2008","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1930","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bone.2005.04.032","article-title":"Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis","volume":"37","author":"Bagger","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.addr.2016.06.005_bb1935","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1002\/art.22075","article-title":"Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis","volume":"54","author":"Manicourt","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.addr.2016.06.005_bb1940","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1359\/JBMR.040609","article-title":"Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency","volume":"19","author":"Behets","year":"2004","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb1945","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.joca.2014.12.019","article-title":"Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials","volume":"23","author":"Karsdal","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.addr.2016.06.005_bb1950","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/0091270010372625","article-title":"Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials","volume":"51","author":"Karsdal","year":"2011","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1955","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2125.2009.03371.x","article-title":"Influence of food intake on the bioavailability and efficacy of oral calcitonin","volume":"67","author":"Karsdal","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb1960","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(97)00130-0","article-title":"Intestinal delivery of calcitonin in pig","volume":"156","author":"New","year":"1997","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb1965","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bej.2008.04.001","article-title":"Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone","volume":"41","author":"Yoshiura","year":"2008","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.addr.2016.06.005_bb1970","unstructured":"Axcess Ltd, US7303762 B2 (2007)."},{"key":"10.1016\/j.addr.2016.06.005_bb1975","series-title":"Proceedings of 44th European Association for the Study of Diabetes Annual Meeting. Rome, Italy","article-title":"Repeat-dosing of oral insulin (Capsulin) in persons with type 2 diabetes","author":"Broke-Smith","year":"2008"},{"key":"10.1016\/j.addr.2016.06.005_bb1980","series-title":"Absorption Enhancers","author":"New","year":"2007"},{"key":"10.1016\/j.addr.2016.06.005_bb1985","unstructured":"Axcess Ltd., US7651995 (2010)."},{"key":"10.1016\/j.addr.2016.06.005_bb1990","unstructured":"Axcess Ltd., US20100056425 (2010)."},{"key":"10.1016\/j.addr.2016.06.005_bb1995","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0168-3659(92)90097-B","article-title":"The synthesis, characterization and biological testing of a novel class of mucosal permeation enhancers","volume":"22","author":"Lee","year":"1992","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2000","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1248\/cpb.29.1998","article-title":"Studies on absorption promoters for rectal delivery preparations. I. Promoting efficacy of enamine derivatives of amino acids for the rectal absorption of beta-lactam antibiotics in rabbits","volume":"29","author":"Murakami","year":"1981","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.2042-7158.1983.tb04294.x","article-title":"Enhancement of rectal absorption of insulin using salicylates in dogs","volume":"35","author":"Nishihata","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2010","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ejps.2013.05.013","article-title":"Characteristics of reversible absorption-enhancing effect of sodium nitroprusside in rat small intestine","volume":"49","author":"Takizawa","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2015","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1248\/cpb.29.2012","article-title":"Study of enamine derivatives of phenylglycine as adjuvants for the rectal absorption of insulin","volume":"29","author":"Kamada","year":"1981","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2020","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-5173(87)90101-3","article-title":"An effective formulation for an insulin suppository; examination in normal dogs","volume":"38","author":"Toshiaki","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0378-5173(86)90007-4","article-title":"Absorption enhancement of growth hormone from the gastrointestinal tract of rats","volume":"34","author":"Moore","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2030","first-page":"611","article-title":"Effect of sodium salicylate on insulin rectal absorption in humans","volume":"44","author":"Hosny","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.addr.2016.06.005_bb2035","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-5173(86)90023-2","article-title":"Trials of rectal insulin suppositories in healthy humans","volume":"34","author":"Toshiaki","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.2042-7158.1983.tb04301.x","article-title":"Insulin suppository: enhanced rectal absorption of insulin using an enamine derivative as a new promoter","volume":"35","author":"Yagi","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2016.06.005_bb2045","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1016\/S0169-409X(01)00180-6","article-title":"Chitosan and its derivatives as intestinal absorption enhancers","volume":"50","author":"Thanou","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb2050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejpb.2004.03.023","article-title":"Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs","volume":"58","author":"van der Merwe","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(99)00365-8","article-title":"Chitosan and its derivatives: potential excipients for peroral peptide delivery systems","volume":"194","author":"Bernkop-Schnurch","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2060","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1517\/17425247.2.5.843","article-title":"The potential of chitosan for the oral administration of peptides","volume":"2","author":"Prego","year":"2005","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb2065","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1023\/A:1016444808000","article-title":"Chitosans as absorption enhancers for poorly absorbable drugs. 1: influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells","volume":"13","author":"Schipper","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2070","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1023\/A:1016488623022","article-title":"Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo","volume":"13","author":"Luessen","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2075","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0378-5173(97)00287-1","article-title":"Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers","volume":"159","author":"Kotz\u00e9","year":"1997","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2004.06.008","article-title":"Characterization of chitosan acetate as a binder for sustained release tablets","volume":"99","author":"Nunthanid","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2085","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3109\/03639045.2013.782501","article-title":"Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets","volume":"40","author":"Viljoen","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2090","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1007\/s11095-014-1613-y","article-title":"The influence of chitosan on the oral bioavailability of acyclovir\u2014a comparative bioavailability study in humans","volume":"32","author":"Kubbinga","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.yrtph.2009.09.015","article-title":"The safety of chitosan as a pharmaceutical excipient","volume":"56","author":"Baldrick","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2100","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2174\/1567201811310030012","article-title":"Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance","volume":"10","author":"Buys","year":"2013","journal-title":"Curr. Drug Deliv."},{"issue":"3","key":"10.1016\/j.addr.2016.06.005_bb2105","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1208\/pt070375","article-title":"Evaluation of powder and tableting properties of chistosan","volume":"7","author":"Picker-Freyer","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2016.06.005_bb2110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1208\/pt070375","article-title":"Evaluation of powder and tableting properties of chitosan","volume":"7","author":"Picker-Freyer","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2016.06.005_bb2115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-5173(99)00126-X","article-title":"Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea","volume":"185","author":"Thanou","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2120","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/0883911503040432","article-title":"Optimized synthesis and characterization of N-triethyl chitosan","volume":"18","author":"Avadi","year":"2003","journal-title":"J. Bioact. Compat. Polym."},{"key":"10.1016\/j.addr.2016.06.005_bb2125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/1520-6017(200101)90:1<38::AID-JPS5>3.0.CO;2-3","article-title":"Mono-N-carboxymethyl chitosan (MCC), a polyampholytic chitosan derivative, enhances the intestinal absorption of low molecular weight heparin across intestinal epithelia in vitro and in vivo","volume":"90","author":"Thanou","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-3659(97)00154-5","article-title":"Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)","volume":"51","author":"Kotze","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2135","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0939-6411(03)00152-8","article-title":"N-trimethyl chitosan chloride as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablet and granule formulations","volume":"57","author":"van der Merwe","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1211\/jpp.60.3.3001","article-title":"Thiolated chitosans: useful excipients for oral drug delivery","volume":"60","author":"Werle","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2003.05.001","article-title":"Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer\/GSH systems","volume":"93","author":"Bernkop-Schnurch","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2011.09.010","article-title":"Thiolated chitosan: development and in vivo evaluation of an oral delivery system for leuprolide","volume":"80","author":"Iqbal","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jconrel.2005.04.004","article-title":"The use of thiolated polymers as carrier matrix in oral peptide delivery\u2014proof of concept","volume":"106","author":"Bernkop-Schnurch","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2160","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijpharm.2007.07.004","article-title":"Thiolated chitosan: development and in vitro evaluation of an oral delivery system for acyclovir","volume":"348","author":"Palmberger","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2165","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jconrel.2003.12.017","article-title":"Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats","volume":"95","author":"Krauland","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-3659(03)00299-2","article-title":"Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin","volume":"92","author":"Guggi","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2175","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1023\/A:1018961204325","article-title":"Mucus gel thickness and turnover in the gastrointestinal tract of the rat: response to cholinergic stimulus and implication for mucoadhesion","volume":"11","author":"Rubinstein","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2180","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.addr.2011.12.014","article-title":"Oral biodrug delivery using cell-penetrating peptide","volume":"64","author":"Khafagy el","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb2185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1096\/fasebj.12.1.67","article-title":"Cell penetration by transportan","volume":"12","author":"Pooga","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2016.06.005_bb2190","series-title":"Cell-Penetrating Peptides","first-page":"3","article-title":"Classes and Prediction of Cell-Penetrating Peptides","author":"Lindgren","year":"2011"},{"key":"10.1016\/j.addr.2016.06.005_bb2195","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1476-5381.2009.00057.x","article-title":"Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics","volume":"157","author":"Heitz","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2200","unstructured":"Unigene Laboratories Ltd., US6673574B2 (2004)."},{"key":"10.1016\/j.addr.2016.06.005_bb2205","unstructured":"Unigene Laboratories Ltd., US6673574 (2004)."},{"key":"10.1016\/j.addr.2016.06.005_bb2210","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj20030760","article-title":"Passage of cell-penetrating peptides across a human epithelial cell layer in vitro","volume":"377","author":"Lindgren","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.addr.2016.06.005_bb2215","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijpharm.2009.07.022","article-title":"Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins","volume":"381","author":"Khafagy","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2220","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jps.23364","article-title":"Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps","volume":"102","author":"Kamei","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2225","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1208\/s12248-015-9804-y","article-title":"Region-dependent role of cell-penetrating peptides in insulin absorption across the rat small intestinal membrane","volume":"17","author":"Khafagy el","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2016.06.005_bb2230","doi-asserted-by":"crossref","unstructured":"Toray Industries Inc., US20120065124 (2012).","DOI":"10.1016\/S1359-6128(12)70110-6"},{"key":"10.1016\/j.addr.2016.06.005_bb2235","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.bpj.2009.08.003","article-title":"Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance","volume":"97","author":"Krug","year":"2009","journal-title":"Biophys. J."},{"key":"10.1016\/j.addr.2016.06.005_bb2240","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biomaterials.2012.09.051","article-title":"Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells","volume":"34","author":"Krug","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2016.06.005_bb2245","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s11095-008-9542-2","article-title":"Mechanistic analysis of chemical permeation enhancers for oral drug delivery","volume":"25","author":"Whitehead","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2250","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ejps.2008.09.011","article-title":"Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate","volume":"36","author":"Sugibayashi","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2255","first-page":"F524","article-title":"A role for intracellular calcium in tight junction reassembly after ATP depletion-repletion","volume":"277","author":"Ye","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb2260","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/physrev.00012.2006","article-title":"Restoration of barrier function in injured intestinal mucosa","volume":"87","author":"Blikslager","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb2265","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0022-3565(25)12150-2","article-title":"Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers","volume":"275","author":"Lindmark","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb2270","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1023\/A:1018835829643","article-title":"Absorption-enhancing effects of sodium caprate and palmitoyl carnitine in rat and human colons","volume":"43","author":"Shimazaki","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2275","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1248\/bpb.20.446","article-title":"The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway","volume":"20","author":"Takahashi","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2280","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijpharm.2004.09.018","article-title":"A practical note on the use of cytotoxicity assays","volume":"288","author":"Weyermann","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2285","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejpb.2015.05.012","article-title":"In silico modelling of permeation enhancement potency in Caco-2 monolayers based on molecular descriptors and random forest","volume":"94","author":"Welling","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2290","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S1461-5347(00)00302-3","article-title":"Enhancing paracellular permeability by modulating epithelial tight junctions","volume":"3","author":"Ward","year":"2000","journal-title":"Pharm. Sci. Technol. Today"},{"key":"10.1016\/j.addr.2016.06.005_bb2295","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/jps.23458","article-title":"Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells","volume":"102","author":"Kiss","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2300","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/109158180302200507","article-title":"Toxicity of excipients\u2014a Food and Drug Administration perspective","volume":"22","author":"Osterberg","year":"2003","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.addr.2016.06.005_bb2305","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0006-2952(00)00576-1","article-title":"Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited","volume":"61","author":"Lichtenberger","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2310","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3109\/00365529709011204","article-title":"Effect of growth factors on epithelial restitution of human colonic mucosa in vitro","volume":"32","author":"Riegler","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2016.06.005_bb2315","first-page":"G384","article-title":"Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion","volume":"261","author":"Kvietys","year":"1991","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb2320","first-page":"G62","article-title":"Restitution of barrier and transport function of porcine colon after acute mucosal injury","volume":"255","author":"Argenzio","year":"1988","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb2325","first-page":"237","article-title":"Rapid barrier restitution in an in vitro model of intestinal epithelial injury","volume":"60","author":"Moore","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb2330","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/gut.38.2.216","article-title":"Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease","volume":"38","author":"Daig","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.addr.2016.06.005_bb2335","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/cs0970385","article-title":"Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro","volume":"97","author":"Wilson","year":"1999","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.addr.2016.06.005_bb2340","first-page":"42","article-title":"CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway","volume":"29","author":"Sturm","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.addr.2016.06.005_bb2345","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/cyto.1999.0518","article-title":"Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro","volume":"12","author":"Brew","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.addr.2016.06.005_bb2350","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1248\/cpb.31.4161","article-title":"Effect of pharmaceutical adjuvants on the rectal permeability of drugs. III. Effect of repeated administration and recovery of the permeability","volume":"31","author":"Nakanishi","year":"1983","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2355","doi-asserted-by":"crossref","first-page":"G157","DOI":"10.1152\/ajpgi.00005.2001","article-title":"Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum","volume":"283","author":"Gookin","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb2360","first-page":"G274","article-title":"Villus contraction aids repair of intestinal epithelium after injury","volume":"257","author":"Moore","year":"1989","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb2365","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1172\/JCI119723","article-title":"Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum","volume":"100","author":"Blikslager","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb2370","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3748\/wjg.v17.i17.2161","article-title":"Wound healing of intestinal epithelial cells","volume":"17","author":"Iizuka","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2016.06.005_bb2375","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11095-007-9354-9","article-title":"In vitro interactions between the oral absorption promoter, sodium caprate (C(10)) and S. typhimurium in rat intestinal ileal mucosae","volume":"25","author":"Cox","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2380","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1016\/j.biomaterials.2011.07.086","article-title":"Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins","volume":"32","author":"Sonaje","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2016.06.005_bb2385","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1248\/bpb.b14-00517","article-title":"Safety of the cell-penetrating peptide penetratin as an oral absorption enhancer","volume":"38","author":"Nielsen","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2390","series-title":"Bacterial Translocation In: Pathophysiology of Shock, Sepsis, And Organ Failure","first-page":"265","author":"Mainous","year":"2012"},{"key":"10.1016\/j.addr.2016.06.005_bb2395","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.mehy.2003.10.037","article-title":"Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?","volume":"63","author":"Ilback","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.addr.2016.06.005_bb2400","first-page":"G224","article-title":"Polyamines attenuate jejunal mucosal injury induced by oleic acid","volume":"263","author":"Kvietys","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb2405","first-page":"24","article-title":"Intestinal epithelium in inflammatory bowel disease","volume":"1","author":"Coskun","year":"2014","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.addr.2016.06.005_bb2410","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.semcdb.2015.05.006","article-title":"Claudin-related intestinal diseases","volume":"42","author":"Barmeyer","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.addr.2016.06.005_bb2415","first-page":"95","article-title":"Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA\u2013EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA","volume":"21","author":"Lanigan","year":"2002","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.addr.2016.06.005_bb2420","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2012.06536.x","article-title":"A phosphorylation hotspot within the occludin C-terminal domain","volume":"1257","author":"Dorfel","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2425","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1073\/pnas.90.16.7824","article-title":"Reversible opening of the blood-brain barrier by anti-bacterial antibodies","volume":"90","author":"Tuomanen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2016.06.005_bb2430","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejps.2013.10.018","article-title":"Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin","volume":"52","author":"Li","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2440","series-title":"42nd Annual Meeting and Exposition of the CRS, Edinburgh, Scotland (Poster 295)","article-title":"Design of a histological score card to standardise the assessment of intestinal toxicity of candidate pharmaceutical excipients","author":"McCartney","year":"2015"},{"key":"10.1016\/j.addr.2016.06.005_bb2445","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0168-3659(92)90007-E","article-title":"A novel in vitro screen to discover agents which increase the absorption of molecules across the intestinal epithelium","volume":"21","author":"Schasteen","year":"1992","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2450","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0022-3565(25)10333-9","article-title":"A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit","volume":"263","author":"Yamamoto","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb2455","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jps.2600750414","article-title":"Contribution of calcium ion sequestration by polyoxyethylated nonionic surfactants to the enhanced colonic absorption of p-aminobenzoic acid","volume":"75","author":"Sakai","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2460","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.2042-7158.1980.tb12927.x","article-title":"Rectal absorption of insulin suppositories in rabbits","volume":"32","author":"Ichikawa","year":"1980","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2465","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1248\/bpb.30.1301","article-title":"Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats","volume":"30","author":"Lin","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2470","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2004.10.010","article-title":"Effect of adsorbents on the absorption of lansoprazole with surfactant","volume":"289","author":"Ito","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2475","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0378-5173(01)00967-X","article-title":"Diethyl ether fraction of Labrasol having a stronger absorption enhancing effect on gentamicin than Labrasol itself","volume":"234","author":"Hu","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2480","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-5173(02)00544-6","article-title":"Enhanced intestinal absorption of vancomycin with Labrasol and D-alpha-tocopheryl PEG 1000 succinate in rats","volume":"250","author":"Prasad","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2485","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpharm.2003.08.008","article-title":"Evaluation of oral formulations of gentamicin containing labrasol in beagle dogs","volume":"268","author":"Rama Prasad","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2495","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10717541003604882","article-title":"Effect of dodecylmaltoside (DDM) on uptake of BCS III compounds, tiludronate and cromolyn, in Caco-2 cells and rat intestine model","volume":"17","author":"Deshmukh","year":"2010","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2016.06.005_bb2500","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.nbt.2013.05.008","article-title":"The Caco-2 cell culture model enables sensitive detection of enhanced protein permeability in the presence of N-decyl-beta-d-maltopyranoside","volume":"30","author":"Marusic","year":"2013","journal-title":"New Biotechnol."},{"key":"10.1016\/j.addr.2016.06.005_bb2505","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1248\/bpb.20.812","article-title":"Effects of various absorption enhancers on the intestinal absorption of water soluble drugs by in vitro Ussing chamber method: correlation with an in situ absorption experiment","volume":"20","author":"Sugiyama","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2510","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.2042-7158.1996.tb03937.x","article-title":"Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane","volume":"48","author":"Yamamoto","year":"1996","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2515","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1248\/bpb.19.1618","article-title":"Effectiveness and toxicity screening of various absorption enhancers in the large intestine: intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane","volume":"19","author":"Uchiyama","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2520","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1248\/bpb.21.615","article-title":"Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers","volume":"21","author":"Quan","year":"1998","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2525","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/jps.21118","article-title":"Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers","volume":"97","author":"Tippin","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2530","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1248\/bpb1978.10.63","article-title":"Effect of phenothiazines, disodium ethylenediaminetetraacetic acid and diethyl maleate on in vitro rat colonic transport of cefmetazole and inulin","volume":"10","author":"Suzuka","year":"1987","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb2535","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(03)00257-6","article-title":"Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate","volume":"260","author":"Dos Santos","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2540","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1023\/A:1015838508656","article-title":"Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines","volume":"8","author":"LeCluyse","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2545","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2133\/dmpk.DMPK-10-RG-071","article-title":"Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers","volume":"26","author":"Doi","year":"2011","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.addr.2016.06.005_bb2550","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/10611860400020191","article-title":"Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin","volume":"13","author":"Yang","year":"2005","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2016.06.005_bb2555","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1023\/A:1012106907708","article-title":"N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2)","volume":"14","author":"Kotze","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2560","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1007558206506","article-title":"N-trimethylated chitosan chloride (TMC) improves the intestinal permeation of the peptide drug buserelin in vitro (Caco-2 cells) and in vivo (rats)","volume":"17","author":"Thanou","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2565","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0022-3565(25)38767-7","article-title":"In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine","volume":"269","author":"Hochman","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb2570","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jps.2600840302","article-title":"Mechanisms of acylcarnitine-mediated enhancement of calcium transport in the Caco-2 cell monolayer model","volume":"84","author":"Surendran","year":"1995","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2575","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1021\/js990094e","article-title":"Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers","volume":"88","author":"Liu","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2580","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/10611869808997879","article-title":"Molecular weight-dependent paracellular transport of fluorescent model compounds induced by palmitoylcarnitine chloride across the human intestinal epithelial cell line Caco-2","volume":"6","author":"Chao","year":"1998","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2016.06.005_bb2585","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2014.06.022","article-title":"In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin","volume":"189","author":"Nielsen","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2590","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1002\/jps.23708","article-title":"Mechanistic study of the uptake\/permeation of cell-penetrating peptides across a caco-2 monolayer and their stimulatory effect on epithelial insulin transport","volume":"102","author":"Kamei","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2600","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/mp400493b","article-title":"Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery","volume":"11","author":"Zhu","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2605","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1161\/hc5001.100837","article-title":"Oral heparin prevents neointimal hyperplasia after arterial injury: inhibitory potential depends on type of vascular injury","volume":"104","author":"Welt","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.addr.2016.06.005_bb2610","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.2042-7158.1990.tb06589.x","article-title":"The effect of fatty acids on the rectal absorption of acyclovir in rats","volume":"42","author":"Yamazaki","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2615","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1023\/A:1015999309353","article-title":"Enhancement of colonic drug absorption by the paracellular permeation route","volume":"5","author":"Tomita","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2620","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jps.2600720615","article-title":"Effects of surfactants on the GI absorption of beta-lactam antibiotics in rats","volume":"72","author":"Miyamoto","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2625","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/03639049809085625","article-title":"Hypoglycemic effect of oral insulin in diabetic rabbits using pH-dependent coated capsules containing sodium salicylate without and with sodium cholate","volume":"24","author":"Hosny","year":"1998","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2630","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1081\/DDC-100107248","article-title":"Effect of different bile salts on the relative hypoglycemia of witepsol W35 suppositories containing insulin in diabetic Beagle dogs","volume":"27","author":"Hosny","year":"2001","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2635","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/jps.2600830606","article-title":"Oral administration of insulin in solid form to nondiabetic and diabetic dogs","volume":"83","author":"Ziv","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2640","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/js960529n","article-title":"Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: assessment by confocal laser scanning microscopy","volume":"86","author":"Sakai","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2645","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/0024-3205(82)90673-7","article-title":"The absorption of insulin from various regions of the rat intestine","volume":"31","author":"Kidron","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2650","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0006-2952(99)00377-9","article-title":"Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats","volume":"59","author":"Lo","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2655","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0024-3205(98)00235-5","article-title":"Effects of absorption enhancers on cytoskeletal actin filaments in Caco-2 cell monolayers","volume":"63","author":"Sakai","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2660","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.farmac.2005.08.007","article-title":"In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies","volume":"60","author":"Sharma","year":"2005","journal-title":"Farmaco"},{"key":"10.1016\/j.addr.2016.06.005_bb2665","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0016-5085(76)80318-6","article-title":"Effect of bile salts and fatty acids on the colonic absorption of oxalate","volume":"70","author":"Dobbins","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2016.06.005_bb2670","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/jps.2600660531","article-title":"Effect of surfactants on absorption through membranes V: concentration-dependent effect of a bile salt (sodium deoxycholate) on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans","volume":"66","author":"Gouda","year":"1977","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2675","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0016-5085(19)32131-6","article-title":"Effects of anionic surfactants on hamster small intestinal membrane structure and function: relationship to surface activity","volume":"73","author":"Gullikson","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2016.06.005_bb2680","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1021\/jf703640p","article-title":"Transport of Val-Leu-Pro-Val-Pro in human intestinal epithelial (Caco-2) cell monolayers","volume":"56","author":"Lei","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb2685","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jps.2600590529","article-title":"Physiologic surface-active agents and drug absorption. VII. Effect of sodium deoxycholate on phenol red absorption in the rat","volume":"59","author":"Feldman","year":"1970","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2690","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijpharm.2005.10.036","article-title":"The evaluation of some pharmaceutically acceptable excipients as permeation enhancers for amoxicillin","volume":"308","author":"Legen","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2695","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1248\/cpb.21.2161","article-title":"Effect of surfactants on drug absorption. IV. Mechanism of the action of sodium glycocholate on the absorption of benzoylthiamine disulfide in the presence of sodium laurylsulfate and polysorbate 80","volume":"21","author":"Utsumi","year":"1973","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2700","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/BF02975268","article-title":"Enhancement of paracellular transport of heparin disaccharide across Caco-2 cell monolayers","volume":"25","author":"Cho","year":"2002","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2705","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1023\/A:1016020505313","article-title":"Effects of permeation enhancers on the transport of a peptidomimetic thrombin inhibitor (CRC 220) in a human intestinal cell line (Caco-2)","volume":"13","author":"Werner","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2710","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1248\/bpb1978.8.578","article-title":"Differences in effects on drug absorption between dihydroxy and trihydroxy bile salts","volume":"8","author":"Kimura","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb2715","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1248\/cpb.18.275","article-title":"Effect of bile salts on the gastrointestinal absorption of drugs. I","volume":"18","author":"Kakemi","year":"1970","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2720","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1248\/cpb.20.1656","article-title":"Effect of bile salts on the gastrointestinal absorption of drugs. IV. Site of intestinal absorption of sodium taurocholate and its consequence on drug absorption in the rat","volume":"20","author":"Kimura","year":"1972","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2725","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0378-5173(93)90280-S","article-title":"Application of sucrose laurate, a new pharmaceutical excipient, in peroral formulations of cyclosporin A","volume":"92","author":"Lerk","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2730","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s11095-012-0785-6","article-title":"CriticalSorb promotes permeation of flux markers across isolated rat intestinal mucosae and Caco-2 monolayers","volume":"29","author":"Brayden","year":"2012","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2735","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1023\/A:1018908903475","article-title":"Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats","volume":"11","author":"Takahashi","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2740","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.2042-7158.1988.tb05333.x","article-title":"The influence of concentration of two salicylate derivatives on rectal insulin absorption enhancement","volume":"40","author":"Hauss","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2745","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1021\/jm020001x","article-title":"Structure\u2013activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines","volume":"45","author":"Ouyang","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb2750","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.2042-7158.1989.tb06468.x","article-title":"3-Amino-1-hydroxypropylidene-1,1-diphosphonate (APD): a novel enhancer of rectal cefoxitin absorption in rats","volume":"41","author":"van Hoogdalem","year":"1989","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2755","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/jps.2600710806","article-title":"Enhanced rectal absorption of theophylline, lidocaine, cefmetazole, and levodopa by several adjuvants","volume":"71","author":"Nishihata","year":"1982","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2760","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2014.03.022","article-title":"In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers","volume":"732","author":"Zhang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2765","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1023\/A:1010936227570","article-title":"Oral delivery of biologically active parathyroid hormone","volume":"18","author":"Leone-Bay","year":"2001","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2770","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2337\/diab.30.12.1065","article-title":"Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate","volume":"30","author":"Nishihata","year":"1981","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2016.06.005_bb2775","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/jps.2600710529","article-title":"Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter","volume":"71","author":"Yoshioka","year":"1982","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2780","first-page":"503","article-title":"Absorption-promoting adjuvants: animal studies on their effects on rectal drug absorption","volume":"6","author":"Caldwell","year":"1984","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2785","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.2042-7158.1981.tb13796.x","article-title":"Enhanced rectal absortion of insulin and heparin in rats in the presence of non-surfactant adjuvants","volume":"33","author":"Nishihata","year":"1981","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2790","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-5173(84)90098-X","article-title":"Enhancement of rectal absorption of water-soluble antibiotics in dogs","volume":"21","author":"Nishihata","year":"1984","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2795","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jps.2600761202","article-title":"Effects of sodium 5-methoxysalicylate on macromolecule absorption and mucosal morphology in a vascularly perfused rat gut preparation in vivo","volume":"76","author":"Peters","year":"1987","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2800","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-5173(84)90092-9","article-title":"Effect of gelatin in the formulation on rectal insulin absorption in the presence of enamine in normal rats and depancreatized dogs","volume":"21","author":"Suni","year":"1984","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2805","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.2042-7158.1983.tb04277.x","article-title":"Effect of enamine derivatives on the rectal absorption of insulin in dogs and rabbits","volume":"35","author":"Kim","year":"1983","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2810","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jps.2600580612","article-title":"Intestinal absorption of heparin facilitated by sulfated or sulfonated surfactants","volume":"58","author":"Engel","year":"1969","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2815","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1055\/s-0029-1185341","article-title":"Intestinal drug transport enhancement by Aloe vera","volume":"75","author":"Chen","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.addr.2016.06.005_bb2820","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1128\/IAI.65.9.3561-3570.1997","article-title":"Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro","volume":"65","author":"Chambers","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.addr.2016.06.005_bb2830","first-page":"155","article-title":"Effects of fatty ethers and stearic acid on the gastrointestinal absorption of insulin","volume":"9","author":"Guzman","year":"1990","journal-title":"P. R. Health Sci. J."},{"key":"10.1016\/j.addr.2016.06.005_bb2835","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1248\/cpb.26.1061","article-title":"Tanaka, rectal absorption of Gly1-alpha1(-18) adrenocorticotropin amide","volume":"26","author":"HirataM","year":"1978","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2840","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jps.2600590708","article-title":"Normal and promoted gastrointestinal absorption of water-soluble substances. I. Induced rapidly reversible hyperabsorptive state in the canine fundic stomach pouch","volume":"59","author":"Davis","year":"1970","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2845","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2337\/diab.21.2.S637","article-title":"New forms of insulin","volume":"21","author":"Galloway","year":"1972","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2016.06.005_bb2850","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0887-2333(00)00014-X","article-title":"Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers","volume":"14","author":"Okada","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.addr.2016.06.005_bb2855","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0168-3659(99)00144-3","article-title":"A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics","volume":"64","author":"Stoll","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2860","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5173(99)00322-1","article-title":"Carrier-enhanced human growth hormone absorption across isolated rabbit intestinal tissue","volume":"197","author":"Mlynek","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2865","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1098-1128(200003)20:2<169::AID-MED4>3.0.CO;2-0","article-title":"The development of delivery agents that facilitate the oral absorption of macromolecular drugs","volume":"20","author":"Leone-Bay","year":"2000","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.addr.2016.06.005_bb2870","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0168-3659(99)00035-8","article-title":"Transport of human growth hormone across Caco-2 cells with novel delivery agents: evidence for P-glycoprotein involvement","volume":"62","author":"Wu","year":"1999","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2875","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0168-3659(97)00259-9","article-title":"Partially unfolded proteins efficiently penetrate cell membranes\u2014implications for oral drug delivery","volume":"53","author":"Milstein","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2880","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.2042-7158.1980.tb12863.x","article-title":"Effective intestinal absorption of insulin in diabetic rats using a new formulation approach","volume":"32","author":"Touitou","year":"1980","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2885","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1476-5381.1981.tb16766.x","article-title":"Enteral administration of insulin in the rat","volume":"73","author":"Bar-On","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb2890","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1128\/AAC.19.5.696","article-title":"Increase of the intestinal absorption of gentamicin and amikacin by a nonionic surfactant","volume":"19","author":"Rubinstein","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2016.06.005_bb2895","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0049-3848(79)90226-3","article-title":"Enteral administration of heparin","volume":"16","author":"Kidron","year":"1979","journal-title":"Thromb. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2900","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0168-3659(95)00146-8","article-title":"The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro","volume":"39","author":"Borchard","year":"1996","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb2905","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0928-0987(99)00093-7","article-title":"Improvement of intestinal peptide absorption by a synthetic bile acid derivative, cholylsarcosine","volume":"10","author":"Michael","year":"2000","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2910","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1073\/pnas.92.23.10629","article-title":"Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia","volume":"92","author":"Nusrat","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2016.06.005_bb2915","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1172\/JCI113760","article-title":"Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers","volume":"82","author":"Hecht","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb2920","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1128\/IAI.69.3.1329-1336.2001","article-title":"Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins","volume":"69","author":"Nusrat","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.addr.2016.06.005_bb2925","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1083\/jcb.102.6.2125","article-title":"Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity","volume":"102","author":"Madara","year":"1986","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb2930","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1023\/A:1018997101542","article-title":"Cyclodextrins as mucosal absorption promoters of insulin. II. Effects of beta-cyclodextrin derivatives on alpha-chymotryptic degradation and enteral absorption of insulin in rats","volume":"11","author":"Shao","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb2935","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-3565(25)24472-X","article-title":"Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells","volume":"272","author":"Tomita","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb2940","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ejpb.2014.10.013","article-title":"Investigation of coco-glucoside as a novel intestinal permeation enhancer in rat models","volume":"88","author":"Aguirre","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2945","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1248\/cpb.34.2628","article-title":"Effect of nonsteroidal anti-inflammatory drugs on the absorption of macromolecular drugs in rat rectum","volume":"34","author":"Nakanishi","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2950","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1248\/cpb.33.740","article-title":"Rectal absorption of [Asu1,7]-eel calcitonin in rats","volume":"33","author":"Miyake","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2955","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0378-5173(86)90042-6","article-title":"The effect of adjuvants on the colonie absorption of cefmetazole and [Asu1,7]-eel calcitonin in rats: concentration dependent absorption pathways","volume":"33","author":"Nishihata","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2960","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1248\/bpb1978.7.607","article-title":"Study of the mechanism behind adjuvant action of diethylethoxymethylene malonate enhancing the rectal absorption of cefmetazole and lysozyme","volume":"7","author":"Nishihata","year":"1984","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb2965","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2004.12.016","article-title":"Diethyl methyl chitosan as an intestinal paracellular enhancer: ex vivo and in vivo studies","volume":"293","author":"Avadi","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb2970","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.lfs.2006.01.044","article-title":"Difructose anhydride III and sodium caprate activate paracellular transport via different intracellular events in Caco-2 cells","volume":"79","author":"Suzuki","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2975","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1248\/cpb.49.1261","article-title":"Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers","volume":"49","author":"Uchida","year":"2001","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2980","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1248\/cpb.40.3042","article-title":"Absorption enhancement of polypeptide drugs by cyclodextrins. I. Enhanced rectal absorption of insulin from hollow-type suppositories containing insulin and cyclodextrins in rabbits","volume":"40","author":"Watanabe","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb2985","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/jps.2600640620","article-title":"Effect of surfactants on absorption through membranes III: effects of dioctyl sodium sulfosuccinate and poloxalene on absorption of a poorly absorbable drug, phenolsulfonphthalein, in rats","volume":"64","author":"Malik","year":"1975","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2990","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jps.2600640621","article-title":"Effect of surfactants on absorption through membranes IV: effects of dioctyl sodium sulfosuccinate on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans","volume":"64","author":"Khalafallah","year":"1975","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb2995","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/jps.2600731106","article-title":"Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs","volume":"73","author":"Nishihata","year":"1984","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3000","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1248\/bpb.18.566","article-title":"Promotion of rectal absorption of sodium ampicillin by disodium glycyrrhetinic acid 3 beta-O-monohemiphthalate in rats","volume":"18","author":"Mishima","year":"1995","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3005","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1128\/IAI.66.11.5125-5131.1998","article-title":"Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells","volume":"66","author":"Gerhard","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.addr.2016.06.005_bb3010","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1021\/js9700309","article-title":"Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size","volume":"86","author":"Knipp","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3015","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1248\/cpb.32.2020","article-title":"Rectal absorption of lysozyme and heparin in rabbits in the presence of non-surfactant adjuvants","volume":"32","author":"Miyake","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jps.2600720318","article-title":"Adjuvant effects of glyceryl esters of acetoacetic acid on rectal absorption of insulin and inulin in rabbits","volume":"72","author":"Nishihata","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3025","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ddr.20087","article-title":"Evaluation of the Oral Bioavailability of Low Molecular Weight Heparin Formulated With Glycyrrhetinic Acid as Permeation Enhancer","volume":"67","author":"Motlekar","year":"2006","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb3030","first-page":"355","article-title":"The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption","volume":"10","author":"Matsumura","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.addr.2016.06.005_bb3035","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bbrc.2005.07.142","article-title":"Insulin-cell penetrating peptide hybrids with improved intestinal absorption efficiency","volume":"335","author":"Liang","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2016.06.005_bb3040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejpb.2014.12.012","article-title":"Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers","volume":"89","author":"Watari","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3045","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1211\/0022357044085","article-title":"Mucoadhesive and penetration enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum","volume":"56","author":"Sandri","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0005-2736(84)90180-9","article-title":"Ortho-hydroxybenzoates may act at the protein fraction to enhance membrane permeability","volume":"775","author":"Nishihata","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb3055","first-page":"G1279","article-title":"Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin","volume":"276","author":"Youakim","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3060","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI113938","article-title":"Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers","volume":"83","author":"Madara","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb3065","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2016.06.005_bb3070","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.150.6.2356","article-title":"IFN-gamma modulation of epithelial barrier function. Time course, reversibility, and site of cytokine binding","volume":"150","author":"Adams","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2016.06.005_bb3075","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.4049\/jimmunol.169.8.4417","article-title":"Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function","volume":"169","author":"Madden","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2016.06.005_bb3080","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.4049\/jimmunol.180.8.5653","article-title":"Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability","volume":"180","author":"Al-Sadi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2016.06.005_bb3085","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2016.06.005_bb3090","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1023\/A:1010664626431","article-title":"Alterations of epithelial permeability by Helicobacter and IL-1beta in vitro: protective effect of rebamipide","volume":"46","author":"Matysiak-Budnik","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3095","doi-asserted-by":"crossref","first-page":"29132","DOI":"10.1074\/jbc.M003516200","article-title":"Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement","volume":"275","author":"Ceponis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2016.06.005_bb3100","doi-asserted-by":"crossref","first-page":"C1046","DOI":"10.1152\/ajpcell.1999.276.5.C1046","article-title":"Role for IL-4 in macromolecular transport across human intestinal epithelium","volume":"276","author":"Berin","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3105","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00383-003-1003-8","article-title":"Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model","volume":"19","author":"Tazuke","year":"2003","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.addr.2016.06.005_bb3110","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1211\/jpp.58.5.0003","article-title":"Modulation of gastrointestinal permeability of low-molecular-weight heparin by L-arginine: in-vivo and in-vitro evaluation","volume":"58","author":"Motlekar","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0378-5173(86)90157-2","article-title":"Promoting effect of Azone on intestinal absorption of poorly absorbable drugs in rats","volume":"31","author":"Murakami","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3120","series-title":"Topics in Pharmaceutical Science","first-page":"445","article-title":"Absorption barriers and absorption promoters in the intestine","author":"Muranishi","year":"1987"},{"key":"10.1016\/j.addr.2016.06.005_bb3125","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/00365529409090437","article-title":"Alteration of colonic absorption by long-chain unsaturated fatty acids. Influence of hydroxylation and degree of unsaturation","volume":"29","author":"Ramakrishna","year":"1994","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2016.06.005_bb3130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00383-002-0860-x","article-title":"Lysophosphatidylcholine alters enterocyte monolayer permeability via a protein kinase C\/Ca2+ mechanism","volume":"18","author":"Sawai","year":"2002","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.addr.2016.06.005_bb3135","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0378-5173(94)00232-T","article-title":"Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines","volume":"114","author":"Hovgaard","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/gut.26.4.369","article-title":"Lysophosphatidylcholine increases rat ileal permeability to macromolecules","volume":"26","author":"Tagesson","year":"1985","journal-title":"Gut"},{"key":"10.1016\/j.addr.2016.06.005_bb3145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0168-3659(95)00057-F","article-title":"Site-specific drug delivery and penetration enhancement in the gastrointestinal tract","volume":"36","author":"Yeh","year":"1995","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1248\/bpb1978.8.653","article-title":"Improvement of bioavailability of poorly absorbed drugs. V. Effect of surfactants on the promoting effect of medium chain glyceride for the rectal absorption of beta-lactam antibiotics in rats and dogs","volume":"8","author":"Sekine","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb3155","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0022-3565(24)36863-6","article-title":"Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP)","volume":"282","author":"Lundin","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb3160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0939-6411(99)00014-4","article-title":"Evaluation of cytotoxicity and absorption enhancing effects of melittin \u2013 a novel absorption enhancer","volume":"48","author":"Liu","year":"1999","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3165","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1007\/s11095-007-9246-z","article-title":"Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae","volume":"24","author":"Maher","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb3170","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1248\/bpb1978.8.1041","article-title":"Enhanced rectal absorption of beta-lactam antibiotics in rat by monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi)","volume":"8","author":"Yata","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2016.06.005_bb3175","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/jps.2600741007","article-title":"Enhanced rectal absorption of sodium ampicillin by N-acyl derivatives of collagen peptide in rabbits and rats","volume":"74","author":"Yata","year":"1985","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3180","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jps.2600760703","article-title":"Enhancement of the rectal absorption of sodium ampicillin by N-acylamino acids in rats","volume":"76","author":"Wu","year":"1987","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00232-008-9099-3","article-title":"Epithelial barrier modulation by a channel forming peptide","volume":"222","author":"Somasekharan","year":"2008","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.addr.2016.06.005_bb3190","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0005-2736(88)90067-3","article-title":"Intestinal absorption enhanced by unsaturated fatty acids: inhibitory effect of sulfhydryl modifiers","volume":"939","author":"Murakami","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2016.06.005_bb3195","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jconrel.2005.05.017","article-title":"Nitric oxide donors can enhance the intestinal transport and absorption of insulin and [Asu(1,7)]-eel calcitonin in rats","volume":"106","author":"Fetih","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3200","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2133\/dmpk.21.222","article-title":"Excellent absorption enhancing characteristics of NO donors for improving the intestinal absorption of poorly absorbable compound compared with conventional absorption enhancers","volume":"21","author":"Fetih","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.addr.2016.06.005_bb3205","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1023\/A:1011920530771","article-title":"Nitric oxide donors enhance rectal absorption of macromolecules in rabbits","volume":"15","author":"Utoguchi","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb3210","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2006.11.002","article-title":"N-sulfonato-N,O-carboxymethylchitosan: a novel polymeric absorption enhancer for the oral delivery of macromolecules","volume":"117","author":"Thanou","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3215","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1021\/mp500626a","article-title":"Absorption Mechanism of a Physical Complex of Monomeric Insulin and Deoxycholyl-l-lysyl-methylester in the Small Intestine","volume":"12","author":"Mahmud","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3220","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/taap.2001.9254","article-title":"The mycotoxin ochratoxin A alters intestinal barrier and absorption functions but has no effect on chloride secretion","volume":"176","author":"Maresca","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3225","doi-asserted-by":"crossref","first-page":"C1412","DOI":"10.1152\/ajpcell.00007.2004","article-title":"Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms","volume":"287","author":"McLaughlin","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb3230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/A:1016368714631","article-title":"Effect of oleic Acid vesicles on intestinal absorption of carboxyfluorescein in rats","volume":"3","author":"Murakami","year":"1986","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb3235","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tiv.2008.10.009","article-title":"The mycotoxin patulin, modulates tight junctions in caco-2 cells","volume":"23","author":"McLaughlin","year":"2009","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.addr.2016.06.005_bb3240","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1016\/j.fct.2012.07.036","article-title":"The mycotoxin patulin increases colonic epithelial permeability in vitro","volume":"50","author":"Mohan","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2016.06.005_bb3245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0378-5173(94)00407-V","article-title":"Intestinal permeation and metabolism of a model peptide (leuprolide) and mechanisms of permeation enhancement by non-ionic surfactants","volume":"120","author":"Imanidis","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3250","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0378-5173(83)90063-7","article-title":"Promoted rectal absorption of insulin: formulative parameters involved in the absorption from hydrophilic bases","volume":"15","author":"Touitou","year":"1983","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3255","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1248\/cpb.33.3527","article-title":"Assessment of pharmaceutical excipient-induced gastrointestinal mucosal damage in rats in vivo by measuring the permeation of phenolsulfonphthalein","volume":"33","author":"Nakamura","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3260","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1248\/cpb.22.523","article-title":"Mechanism of drug absorption from micellar solution. II. Effect of polysorbate 80 on the absorption of micelle-free drugs","volume":"22","author":"Kaneda","year":"1974","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3265","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1476-5381.1993.tb12799.x","article-title":"Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether","volume":"108","author":"Drewe","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3270","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0378-5173(88)90106-8","article-title":"Increased systemic availability of cyclosporin A by formulation design: pharmacokinetic consideration on its transport","volume":"44","author":"Takada","year":"1988","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3275","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1023\/A:1010696005958","article-title":"Phorbol ester treatment increases paracellular permeability across IEC-18 gastrointestinal epithelium in vitro","volume":"46","author":"Marano","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3280","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1007\/BF02209017","article-title":"Phorbol myristate acetate ex vivo model of enhanced colonic epithelial permeability. Reactive oxygen metabolite and protease independence","volume":"40","author":"Berin","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3285","first-page":"G214","article-title":"Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester","volume":"266","author":"Hecht","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3290","first-page":"G955","article-title":"Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C","volume":"265","author":"Stenson","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3295","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.2042-7158.1998.tb06187.x","article-title":"The effect of a drug-delivery system consisting of soybean phosphatidyl choline and medium-chain monoacylglycerol on the intestinal permeability of hexarelin in the rat","volume":"50","author":"Fagerholm","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3300","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jconrel.2008.07.016","article-title":"Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery","volume":"131","author":"Kamei","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3305","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2006.12.022","article-title":"A novel approach using functional peptides for efficient intestinal absorption of insulin","volume":"118","author":"Morishita","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3310","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1248\/bpb.b12-00974","article-title":"Effect of poly-L-arginine on intestinal absorption of hydrophilic macromolecules in rats","volume":"36","author":"Yamaki","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3315","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0955-2863(01)00208-X","article-title":"The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1)","volume":"13","author":"Ranaldi","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.addr.2016.06.005_bb3320","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-3565(25)12024-7","article-title":"Role of Na+ in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across rabbit colonic segments and Caco-2 cell monolayers","volume":"275","author":"Yen","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb3325","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1021\/js9800735","article-title":"Enhancement of intestinal model compound transport by DS-1, a modified Quillaja saponin","volume":"87","author":"Chao","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3330","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijpharm.2013.02.003","article-title":"Rhamnolipids enhance epithelial permeability in Caco-2 monolayers","volume":"446","author":"Jiang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3335","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jps.21093","article-title":"Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer","volume":"97","author":"Tsutsumi","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3340","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0022-3565(25)24258-6","article-title":"Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter","volume":"244","author":"Aungst","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb3345","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1271\/bbb.62.443","article-title":"Physico-chemical Properties of Fatty Acids for Assessing the Threshold Concentration to Enhance the Absorption of a Hydrophilic Substance","volume":"62","author":"Kimura","year":"1998","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2016.06.005_bb3350","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1271\/bbb.65.743","article-title":"Effects of medium-chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco-2) cell monolayers","volume":"65","author":"Kimura","year":"2001","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2016.06.005_bb3355","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jconrel.2004.06.007","article-title":"Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine","volume":"99","author":"Miyake","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3360","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.2042-7158.1981.tb13931.x","article-title":"Rectal absorption of some glycosaminoglycan sulphates and heparin in rats","volume":"33","author":"Stanzani","year":"1981","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2016.06.005_bb3365","first-page":"G361","article-title":"Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers","volume":"268","author":"Salzman","year":"1995","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3370","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/AAC.28.2.211","article-title":"Use of adjuvants for enhancement of rectal absorption of cefoxitin in humans","volume":"28","author":"Davis","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2016.06.005_bb3375","first-page":"361","article-title":"Evaluation of efficiency of insulin suppository formulations containing sodium salicylate or sodium cholate in insulin dependent diabetic patients","volume":"142","author":"Hosny","year":"2003","journal-title":"Boll. Chim. Farm."},{"key":"10.1016\/j.addr.2016.06.005_bb3380","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0022-3565(25)39367-5","article-title":"Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy","volume":"267","author":"Hurni","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb3385","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2010.12.001","article-title":"Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption","volume":"13","author":"Chopra","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.addr.2016.06.005_bb3390","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/jps.2600721006","article-title":"Influence of ionic strength on rectal absorption of gentamicin sulfate in the presence and absence of sodium salicylate","volume":"72","author":"Fix","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3395","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-5173(90)90117-M","article-title":"Intestinal absorption enhancement by sodium taurodihydrofusidate of a peptide hormone analogue (dDAVP) and a macromolecule (BSA) in vitro and in vivo","volume":"59","author":"Lundin","year":"1990","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2016.06.005_bb3400","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0022-3565(25)20872-2","article-title":"Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats","volume":"251","author":"van Hoogdalem","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2016.06.005_bb3405","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1023\/A:1015837004307","article-title":"Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats","volume":"7","author":"van Hoogdalem","year":"1990","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2016.06.005_bb3410","first-page":"G816","article-title":"Role of tight-junctional pathways in bile salt-induced increases in colonic permeability","volume":"245","author":"Freel","year":"1983","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2016.06.005_bb3415","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/jps.2600580813","article-title":"Physiologic surface-active agents and drug absorption II. Comparison of the effect of sodium taurodeoxycholate and ethylenediaminetetraacetic acid on salicylamide and salicylate transfer across the everted rat small intestine","volume":"58","author":"Feldman","year":"1969","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3420","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0742-8413(98)00042-5","article-title":"Spermine affects intestinal in vitro permeability to different-sized molecules in rats","volume":"120","author":"Osman","year":"1998","journal-title":"Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol."},{"key":"10.1016\/j.addr.2016.06.005_bb3425","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jconrel.2006.07.015","article-title":"Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption","volume":"115","author":"Miyake","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3430","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1177\/1087057107310216","article-title":"Phage display screening of epithelial cell monolayers treated with EGTA: identification of peptide FDFWITP that modulates tight junction activity","volume":"12","author":"Herman","year":"2007","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.addr.2016.06.005_bb3435","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb3440","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1749-6632.2000.tb05242.x","article-title":"Epithelial barrier defects in HT-29\/B6 colonic cell monolayers induced by tumor necrosis factor-alpha","volume":"915","author":"Gitter","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.addr.2016.06.005_bb3445","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1006\/cyto.1995.0060","article-title":"Tumour necrosis factor-alpha induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers","volume":"7","author":"Rodriguez","year":"1995","journal-title":"Cytokine"},{"key":"10.1016\/j.addr.2016.06.005_bb3450","doi-asserted-by":"crossref","first-page":"G422","DOI":"10.1152\/ajpgi.00412.2004","article-title":"Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression","volume":"288","author":"Ma","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2016.06.005_bb3455","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jconrel.2010.01.019","article-title":"Structural requirements of penetratin absorption enhancement efficiency for insulin delivery","volume":"143","author":"Khafagy el","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2016.06.005_bb3460","first-page":"339","article-title":"Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery","volume":"54","author":"Younessi","year":"2004","journal-title":"Acta Pharm. (Zagreb, Croatia)"},{"key":"10.1016\/j.addr.2016.06.005_bb3465","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI2764","article-title":"Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin","volume":"102","author":"Papini","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2016.06.005_bb3470","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1248\/bpb.25.678","article-title":"Pharmacokinetics and pharmacodynamics of human chorionic gonadotropin (hCG) after rectal administration of hollow-type suppositories containing hCG","volume":"25","author":"Kowari","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2016.06.005_bb3475","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0939-6411(99)00083-1","article-title":"Enhancing effect of 5 alpha-cyprinol sulfate on mucosal membrane permeability to sodium ampicillin in rats","volume":"49","author":"Murakami","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X16301892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X16301892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T18:14:11Z","timestamp":1748974451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X16301892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":689,"alternative-id":["S0169409X16301892"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2016.06.005","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal permeation enhancers for oral peptide delivery","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2016.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}