{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:47:59Z","timestamp":1791978479583,"version":"4.4.0"},"reference-count":292,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.addr.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T01:54:43Z","timestamp":1484877283000},"page":"73-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":134,"special_numbering":"C","title":["Xenobiotic transporters and kidney injury"],"prefix":"10.1016","volume":"116","author":[{"given":"Blessy","family":"George","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-4604","authenticated-orcid":false,"given":"Dahea","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie S.","family":"Joy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Aleksunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2017.01.005_bb0005","series-title":"The Kidney","first-page":"2923","article-title":"Disposition and dose requirements of drugs in renal insufficiency","author":"Brater","year":"2000"},{"key":"10.1016\/j.addr.2017.01.005_bb0010","first-page":"F122","article-title":"Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney","volume":"276","author":"Hosoyamada","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2017.01.005_bb0015","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1681\/ASN.V103464","article-title":"Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney","volume":"10","author":"Tojo","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0020","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1074\/jbc.M508050200","article-title":"Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice","volume":"281","author":"Eraly","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0025","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/jpet.301.3.797","article-title":"Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors","volume":"301","author":"Enomoto","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0030","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1124\/mol.59.5.1277","article-title":"Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney","volume":"59","author":"Cha","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0035","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1681\/ASN.V134848","article-title":"Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney","volume":"13","author":"Kojima","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0040","doi-asserted-by":"crossref","first-page":"C1075","DOI":"10.1152\/ajpcell.00619.2004","article-title":"Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites","volume":"289","author":"Bahn","year":"2005","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0045","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1124\/dmd.114.062364","article-title":"Characterization of organic anion transporter 2 (SLC22A7): a highly efficient transporter for creatinine and species-dependent renal tubular expression","volume":"43","author":"Shen","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0050","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1254\/jphs.94.297","article-title":"Human organic anion transporter 4 is a renal apical organic anion\/dicarboxylate exchanger in the proximal tubules","volume":"94","author":"Ekaratanawong","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb0055","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1124\/jpet.105.088583","article-title":"Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules","volume":"315","author":"Anzai","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0014-2999(02)01306-7","article-title":"Interaction of human organic anion transporters with various cephalosporin antibiotics","volume":"438","author":"Takeda","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0065","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0026-895X(24)23181-3","article-title":"Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes","volume":"55","author":"Apiwattanakul","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00240295","article-title":"Functional expression of renal organic anion transport in Xenopus laevis oocytes","volume":"114","author":"Wolff","year":"1992","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.addr.2017.01.005_bb0075","doi-asserted-by":"crossref","first-page":"18526","DOI":"10.1074\/jbc.272.30.18526","article-title":"Expression cloning and characterization of a novel multispecific organic anion transporter","volume":"272","author":"Sekine","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0080","doi-asserted-by":"crossref","first-page":"30088","DOI":"10.1074\/jbc.272.48.30088","article-title":"Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney","volume":"272","author":"Sweet","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000074539","article-title":"Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux","volume":"13","author":"Bakhiya","year":"2003","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.addr.2017.01.005_bb0090","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00424-003-1089-9","article-title":"The SLC22 drug transporter family","volume":"447","author":"Koepsell","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.addr.2017.01.005_bb0095","doi-asserted-by":"crossref","first-page":"F679","DOI":"10.1152\/ajprenal.2000.279.4.F679","article-title":"Localization of organic cation transporters OCT1 and OCT2 in rat kidney","volume":"279","author":"Karbach","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0100","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1681\/ASN.V134866","article-title":"Gene expression levels and immunolocalization of organic ion transporters in the human kidney","volume":"13","author":"Motohashi","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11095-004-1193-3","article-title":"Metformin transport by renal basolateral organic cation transporter hOCT2","volume":"22","author":"Kimura","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2017.01.005_bb0110","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/S0002-9440(10)61234-5","article-title":"Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2","volume":"167","author":"Ciarimboli","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2017.01.005_bb0115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bcp.2007.03.004","article-title":"Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity","volume":"74","author":"Yokoo","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-5793(97)01441-5","article-title":"Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1","volume":"419","author":"Tamai","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0005-2736(01)00328-5","article-title":"Na(+)-coupled transport of l-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney","volume":"1512","author":"Tamai","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.01.005_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1021\/mp0340082","article-title":"Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations","volume":"1","author":"Tamai","year":"2004","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2017.01.005_bb0135","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0022-3565(24)35167-5","article-title":"Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance","volume":"291","author":"Ohashi","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2000","key":"10.1016\/j.addr.2017.01.005_bb0140","article-title":"Beta-lactam antibiotics as substrates for OCTN2, an organic cation\/carnitine transporter","volume":"275","author":"Ganapathy","year":"1699","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0145","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1073\/pnas.0304987101","article-title":"Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney","volume":"101","author":"Mikkaichi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.01.005_bb0150","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2133\/dmpk.19.171","article-title":"The organic anion transporter (OATP) family","volume":"19","author":"Mikkaichi","year":"2004","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.addr.2017.01.005_bb0155","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-3565(24)29609-9","article-title":"Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes","volume":"297","author":"Nakai","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0160","first-page":"F756","article-title":"Cyclosporin a treatment induces overexpression of P-glycoprotein in the kidney and other tissues","volume":"270","author":"Jette","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2017.01.005_bb0165","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000190289","article-title":"Expression of MDR1 (multidrug resistance) gene and its protein in normal human kidney","volume":"77","author":"Ernest","year":"1997","journal-title":"Nephron"},{"key":"10.1016\/j.addr.2017.01.005_bb0170","first-page":"213","article-title":"Multidrug resistance mediated by P-glycoproteins","volume":"2","author":"Schinkel","year":"1991","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.addr.2017.01.005_bb0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/bi00001a005","article-title":"Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators","volume":"34","author":"Tang-Wai","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2017.01.005_bb0180","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1124\/dmd.107.019125","article-title":"Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics","volume":"36","author":"Kato","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0185","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.V881213","article-title":"Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules","volume":"8","author":"Schaub","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0190","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1124\/jpet.105.090613","article-title":"Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats","volume":"315","author":"Ghanem","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0195","first-page":"5269","article-title":"Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies","volume":"60","author":"Scheffer","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2017.01.005_bb0200","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1681\/ASN.V133595","article-title":"The MRP4\/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP","volume":"13","author":"van Aubel","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0205","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1097\/01.ASN.0000143473.64430.AC","article-title":"Contribution of multidrug resistance protein 2 (MRP2\/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter","volume":"15","author":"Smeets","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0210","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1124\/dmd.104.003319","article-title":"Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP\/ABCG2)","volume":"33","author":"Merino","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0215","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4161\/cbt.4.2.1440","article-title":"ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy","volume":"4","author":"Robey","year":"2005","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0220","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2005.07.032","article-title":"Membrane transporters and channels in chemoresistance and sensitivity of tumor cells","volume":"239","author":"Huang","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0225","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1124\/dmd.107.014969","article-title":"Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones","volume":"35","author":"Ando","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0230","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1124\/mol.107.034751","article-title":"Effect of breast cancer resistance protein (Bcrp\/Abcg2) on the disposition of phytoestrogens","volume":"72","author":"Enokizono","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0235","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1124\/dmd.106.014274","article-title":"Abcg2\/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine","volume":"35","author":"Pan","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0240","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.taap.2008.07.006","article-title":"ABCG2\/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta","volume":"232","author":"Myllynen","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0245","first-page":"22","article-title":"The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells","volume":"8","author":"Kim","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.addr.2017.01.005_bb0250","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/sj.ki.5002645","article-title":"The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane","volume":"73","author":"Huls","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb0255","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1128\/JB.187.5.1552-1558.2005","article-title":"Identification of essential amino acid residues of the NorM Na+\/multidrug antiporter in Vibrio parahaemolyticus","volume":"187","author":"Otsuka","year":"2005","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.addr.2017.01.005_bb0260","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1681\/ASN.2006030205","article-title":"Identification and functional characterization of a new human kidney-specific H+\/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2","volume":"17","author":"Masuda","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0265","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.bcp.2006.12.034","article-title":"Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats","volume":"73","author":"Nishihara","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0270","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bcp.2007.04.010","article-title":"Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions\/H(+)-organic cation antiporters","volume":"74","author":"Tanihara","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0275","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1124\/dmd.106.010876","article-title":"Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation\/H+ antiporter in the kidney","volume":"34","author":"Ohta","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0280","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s11095-006-9016-3","article-title":"Molecular cloning, functional characterization and tissue distribution of rat H+\/organic cation antiporter MATE1","volume":"23","author":"Terada","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2017.01.005_bb0285","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/jpet.107.123554","article-title":"Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family","volume":"322","author":"Chen","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0290","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"Dehghan","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2017.01.005_bb0295","doi-asserted-by":"crossref","first-page":"35123","DOI":"10.1074\/jbc.M110.121301","article-title":"Human sodium phosphate transporter 4 (hNPT4\/SLC17A3) as a common renal secretory pathway for drugs and urate","volume":"285","author":"Jutabha","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0300","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s004320050186","article-title":"Renal cell cancer correlated with occupational exposure to trichloroethene","volume":"124","author":"Vamvakas","year":"1998","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.addr.2017.01.005_bb0305","first-page":"777","article-title":"Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: epidemiological aspects","volume":"50","author":"Charbotel","year":"2006","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.addr.2017.01.005_bb0310","series-title":"Carcinogenesis Studies of Trichloroethylene (without Epichlorhydrin) (CAS No. 79-01-6) in F344\/N Rats and B6C3F1 Mice (Gavage Studies)","year":"1990"},{"key":"10.1016\/j.addr.2017.01.005_bb0315","series-title":"Toxicology and Carcinogenesis Studies of Trichloroethylene (CAS No. 79-01-6) in four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)","year":"1988"},{"key":"10.1016\/j.addr.2017.01.005_bb0320","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3109\/10408448809037470","article-title":"Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites","volume":"18","author":"Anders","year":"1988","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0325","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1021\/bi00534a041","article-title":"Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide","volume":"21","author":"Miller","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.addr.2017.01.005_bb0330","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0090-9556(24)14910-0","article-title":"Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation","volume":"27","author":"Lash","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0335","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2007.03.001","article-title":"Modulation of hepatic and renal metabolism and toxicity of trichloroethylene and perchloroethylene by alterations in status of cytochrome P450 and glutathione","volume":"235","author":"Lash","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb0340","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/15287390500360133","article-title":"Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine","volume":"69","author":"Lash","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.addr.2017.01.005_bb0345","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s002040050319","article-title":"Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves","volume":"70","author":"Lock","year":"1996","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002040050461","article-title":"Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates","volume":"72","author":"Birner","year":"1997","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0355","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0090-9556(25)06667-X","article-title":"Glutathione-dependent metabolism of trichloroethylene in isolated liver and kidney cells of rats and its role in mitochondrial and cellular toxicity","volume":"23","author":"Lash","year":"1995","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/009841099158204","article-title":"Identification of S-(1,2-dichlorovinyl)glutathione in the blood of human volunteers exposed to trichloroethylene","volume":"56","author":"Lash","year":"1999","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.addr.2017.01.005_bb0365","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-3565(24)29523-9","article-title":"Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: sex-, species-, and tissue-dependent differences","volume":"297","author":"Lash","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0370","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1021\/tx990090p","article-title":"Acylase-catalyzed deacetylation of haloalkene-derived mercapturates","volume":"12","author":"Uttamsingh","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0375","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/tx980084d","article-title":"Chlorothioketene, the ultimate reactive intermediate formed by cysteine conjugate beta-lyase-mediated cleavage of the trichloroethene metabolite S-(1,2-dichlorovinyl)-l-cysteine, forms cytosine adducts in organic solvents, but not in aqueous solution","volume":"11","author":"Volkel","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0380","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0009-2797(88)90093-2","article-title":"Thioacylating agents as ultimate intermediates in the beta-lyase catalysed metabolism of S-(pentachloro-butadienyl)-l-cysteine","volume":"67","author":"Dekant","year":"1988","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.addr.2017.01.005_bb0385","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1021\/tx9701438","article-title":"Reactivity of haloketenes and halothioketenes with nucleobases: chemical characterization of reaction products","volume":"11","author":"Muller","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0390","doi-asserted-by":"crossref","first-page":"18415","DOI":"10.1016\/S0021-9258(18)55074-2","article-title":"Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts","volume":"266","author":"Hayden","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0395","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/01480548608998281","article-title":"Early biological indicators of S-(1,2-dichlorovinyl)-l-cysteine nephrotoxicity in the rabbit","volume":"9","author":"Silber","year":"1986","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9295","article-title":"Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-l-cysteine in primary cultures of human proximal tubular cells","volume":"177","author":"Lash","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0405","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1289\/ehp.9399281","article-title":"Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-l-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure","volume":"99","author":"Birner","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0410","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0041-008X(89)90270-6","article-title":"N-acetyl S-(1,2-dichlorovinyl)-l-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-l-cysteine in rabbit renal slices: differential transport and metabolism","volume":"101","author":"Wolfgang","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0415","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0022-3565(24)37556-1","article-title":"Relation of cysteine conjugate nephrotoxicity to transport by the basolateral organic anion transport system in isolated S2 segments of rabbit proximal renal tubules","volume":"286","author":"Dantzler","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0420","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1124\/jpet.102.043455","article-title":"Interaction of cysteine conjugates with human and rabbit organic anion transporter 1","volume":"304","author":"Groves","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0425","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0022-3565(25)23734-X","article-title":"Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells","volume":"248","author":"Lash","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0430","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0026-895X(25)10461-6","article-title":"The transport of S-cysteine conjugates in LLC-PK1 cells and its role in toxicity","volume":"31","author":"Schaeffer","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0435","first-page":"293","article-title":"Mechanism of transport for toxic cysteine conjugates in rat kidney cortex membrane vesicles","volume":"32","author":"Schaeffer","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0440","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-3565(24)37405-1","article-title":"Na-dependent transport of S-(1,2-dichlorovinyl)-l-cysteine by renal brush-border membrane vesicles","volume":"285","author":"Wright","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0445","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.taap.2009.12.035","article-title":"Transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2)","volume":"244","author":"Tsirulnikov","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0450","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1136\/bmj.1.5498.1272","article-title":"Accidental poisoning by paraquat: report of two cases in man","volume":"1","author":"Bullivant","year":"1966","journal-title":"Br. Med. J."},{"key":"10.1016\/j.addr.2017.01.005_bb0455","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/096032719000900103","article-title":"Toxicokinetics of paraquat in humans","volume":"9","author":"Houze","year":"1990","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0460","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/252314b0","article-title":"Evidence for energy-dependent accumulation of paraquat into rat lung","volume":"252","author":"Rose","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.addr.2017.01.005_bb0465","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nbdi.2002.0507","article-title":"Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat","volume":"10","author":"McCormack","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.addr.2017.01.005_bb0470","first-page":"133","article-title":"Absorption and excretion of diquat and paraquat in rats","volume":"23","author":"Daniel","year":"1966","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4274(96)03820-9","article-title":"The mechanism of excretion of paraquat in rats","volume":"90","author":"Chan","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0480","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/096032718700600105","article-title":"Mechanism of paraquat toxicity in lung and its relevance to treatment","volume":"6","author":"Smith","year":"1987","journal-title":"Hum. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0485","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0041-008X(75)90185-4","article-title":"Nephrotoxicity of paraquat in mice","volume":"34","author":"Ecker","year":"1975","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0490","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0041-008X(79)90039-5","article-title":"The effect of paraquat and diquat on renal function in the rat","volume":"48","author":"Lock","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0495","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0041-008X(79)90493-9","article-title":"The acute toxic effects of paraquat and diquat on the rat kidney","volume":"50","author":"Lock","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0500","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3109\/15563657108990492","article-title":"Paraquat poisoning-prolonged excretion","volume":"4","author":"Beebeejaun","year":"1971","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0505","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0300-9432(73)90018-6","article-title":"Poisoning with paraquat","volume":"2","author":"Kodagoda","year":"1973","journal-title":"Forensic Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb0510","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/096032718700600107","article-title":"Paraquat poisoning: clinical features and immediate general management","volume":"6","author":"Vale","year":"1987","journal-title":"Hum. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0515","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/archinte.1979.03630390032014","article-title":"Nephrotoxicity of paraquat in man","volume":"139","author":"Vaziri","year":"1979","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb0520","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0022-3565(25)21170-3","article-title":"Transport of paraquat in a renal epithelial cell line LLC-PK1","volume":"279","author":"Chan","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0525","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/096032719601501202","article-title":"Characterisation and uptake of paraquat by rat renal proximal tubular cells in primary culture","volume":"15","author":"Chan","year":"1996","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0530","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1124\/dmd.106.013581","article-title":"Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population","volume":"35","author":"Kang","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb0535","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1080\/00498250802130039","article-title":"Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes","volume":"38","author":"Song","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.addr.2017.01.005_bb0540","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0005-2736(95)00166-0","article-title":"Paraquat2+\/H+ exchange in isolated renal brush-border membrane vesicles","volume":"1240","author":"Wright","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.01.005_bb0545","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1021\/mp200395f","article-title":"Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice","volume":"8","author":"Li","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2017.01.005_bb0550","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.freeradbiomed.2006.06.012","article-title":"P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity","volume":"41","author":"Dinis-Oliveira","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb0555","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/toxsci\/kfu141","article-title":"MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells","volume":"141","author":"Wen","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb0560","first-page":"193","article-title":"Handbook of Foodborne Diseases of Biological Origin","author":"Harwig","year":"1983"},{"key":"10.1016\/j.addr.2017.01.005_bb0565","series-title":"Toxicology of Kidney","first-page":"895","article-title":"Mycotoxins affecting the kidney","author":"O'Brien","year":"2004"},{"key":"10.1016\/j.addr.2017.01.005_bb0570","first-page":"243","article-title":"Ochratoxin A contamination of foodstuffs in an area with Balkan (endemic) nephropathy","volume":"87","author":"Pavlovic","year":"1979","journal-title":"Acta Pathol. Microbiol. Scand. B"},{"key":"10.1016\/j.addr.2017.01.005_bb0575","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1751-0813.1984.tb05993.x","article-title":"Experimental ochratoxicosis A in pigs","volume":"61","author":"Tapia","year":"1984","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.addr.2017.01.005_bb0580","series-title":"Mycotoxins: Risks in Plant, Animal, and Human Systems, Task Force Report No. 139","first-page":"199","author":"C.C.f.A.S.a. Technology","year":"2003"},{"key":"10.1016\/j.addr.2017.01.005_bb0585","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0300-483X(84)90080-5","article-title":"Teratogenic effects of ochratoxin A in rats with impaired renal function","volume":"32","author":"Mayura","year":"1984","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb0590","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/AEM.41.4.1040-1042.1981","article-title":"Immunosuppression by ochratoxin A and its prevention by phenylalanine","volume":"41","author":"Haubeck","year":"1981","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0595","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0278-6915(85)90112-7","article-title":"Ochratoxin A: plasma concentration and excretion into bile and urine in albumin-deficient rats","volume":"23","author":"Kumagai","year":"1985","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0600","first-page":"33","article-title":"High affinity binding of ochratoxin A to plasma constituents","volume":"9","author":"Stojkovic","year":"1984","journal-title":"Biochem. Int."},{"key":"10.1016\/j.addr.2017.01.005_bb0605","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jat.2550090204","article-title":"Toxicokinetics of ochratoxin A in several species and its plasma-binding properties","volume":"9","author":"Hagelberg","year":"1989","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0610","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2005.10.106","article-title":"Toxicokinetics and toxicodynamics of ochratoxin A, an update","volume":"159","author":"Ringot","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.addr.2017.01.005_bb0615","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/15287398509530766","article-title":"Renal tubular secretion and reabsorption as factors in ochratoxicosis: effects of probenecid on nephrotoxicity","volume":"16","author":"Stein","year":"1985","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb0620","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0015-6264(79)90347-X","article-title":"The kidney and ochratoxin A","volume":"17","author":"Cooper","year":"1979","journal-title":"Food Cosmet. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0625","first-page":"733","article-title":"Ochratoxin A carcinogenesis in the (C57BL\/6J X C3H)F1 mouse","volume":"75","author":"Bendele","year":"1985","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.addr.2017.01.005_bb0630","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0278-6915(84)90170-4","article-title":"Inhibition of protein synthesis in mice by ochratoxin A and its prevention by phenylalanine","volume":"22","author":"Creppy","year":"1984","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0635","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2014.01.016","article-title":"Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin a","volume":"132","author":"Poor","year":"2014","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.addr.2017.01.005_bb0640","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1021\/tx200430f","article-title":"An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity","volume":"25","author":"Pfohl-Leszkowicz","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0645","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/toxins5101742","article-title":"Toxicity of ochratoxin A and its modulation by antioxidants: a review","volume":"5","author":"Sorrenti","year":"2013","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.addr.2017.01.005_bb0650","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0024-3205(01)01296-6","article-title":"Characterization of ochratoxin A transport by human organic anion transporters","volume":"69","author":"Jung","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb0655","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-3565(25)22073-0","article-title":"Mechanism of ochratoxin A transport in kidney","volume":"246","author":"Sokol","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0660","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0022-3565(24)37350-1","article-title":"Peritubular transport of ochratoxin A in rabbit renal proximal tubules","volume":"284","author":"Groves","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0665","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0022-3565(24)38273-4","article-title":"Transport of ochratoxin A by renal multispecific organic anion transporter 1","volume":"289","author":"Tsuda","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0670","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0167-4889(02)00187-8","article-title":"Role of human organic anion transporter 4 in the transport of ochratoxin A","volume":"1590","author":"Babu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.01.005_bb0675","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1681\/ASN.V9111973","article-title":"Peritubular transport of ochratoxin A by single rabbit renal proximal tubules","volume":"9","author":"Welborn","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0680","first-page":"G231","article-title":"Immunologic distribution of an organic anion transport protein in rat liver and kidney","volume":"271","author":"Bergwerk","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2017.01.005_bb0685","first-page":"G1037","article-title":"Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells","volume":"276","author":"Eckhardt","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.addr.2017.01.005_bb0690","doi-asserted-by":"crossref","first-page":"F236","DOI":"10.1152\/ajprenal.00012.2004","article-title":"Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney","volume":"287","author":"Youngblood","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0695","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0022-3565(24)29326-5","article-title":"Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2","volume":"299","author":"Takeuchi","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0700","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3565(24)37570-6","article-title":"Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms","volume":"286","author":"Dahlmann","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0705","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1046\/j.1523-1755.2000.00007.x","article-title":"ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2","volume":"57","author":"Leier","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb0710","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00204-005-0041-5","article-title":"Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 cells","volume":"80","author":"Schrickx","year":"2006","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0715","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-291X(02)02389-6","article-title":"Functional analysis of ABCA8, a new drug transporter","volume":"298","author":"Tsuruoka","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2017.01.005_bb0720","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1440-1681.2005.04301.x","article-title":"Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver","volume":"32","author":"Wakaumi","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0725","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1254\/jphs.10227SC","article-title":"A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A","volume":"116","author":"Jutabha","year":"2011","journal-title":"J. Pharmacol. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2017.01.005_bb0730","first-page":"1","article-title":"Health effects of cadmium exposure\u2013a review of the literature and a risk estimate","volume":"24","author":"Jarup","year":"1998","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb0735","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1289\/ehp.941021058","article-title":"Intestinal absorption of dietary cadmium in women depends on body iron stores and fiber intake","volume":"102","author":"Berglund","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0740","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1289\/ehp.6751","article-title":"Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke","volume":"112","author":"Satarug","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0745","first-page":"385","article-title":"Immunotoxicology of cadmium","author":"Descotes","year":"1992","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.addr.2017.01.005_bb0750","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000402891","article-title":"Cadmium nephropathy","volume":"16","author":"Kazantzis","year":"1979","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb0755","first-page":"301","article-title":"Mechanism and epidemiology of bone effects of cadmium","author":"Kjellstrom","year":"1992","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.addr.2017.01.005_bb0760","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1289\/ehp.7928199","article-title":"Mortality and cancer morbidity among cadmium-exposed workers","volume":"28","author":"Kjellstrom","year":"1979","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0765","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/ATVBAHA.109.190082","article-title":"Cadmium is a novel and independent risk factor for early atherosclerosis mechanisms and in vivo relevance","volume":"29","author":"Messner","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.addr.2017.01.005_bb0770","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2337\/diacare.26.2.468","article-title":"Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III","volume":"26","author":"Schwartz","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.addr.2017.01.005_bb0775","first-page":"161","article-title":"Pulmonary effects of chronic exposure to airborne cadmium","volume":"114","author":"Smith","year":"1976","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.addr.2017.01.005_bb0780","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/oem.57.1.19","article-title":"Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study","volume":"57","author":"Viaene","year":"2000","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb0785","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1078\/0171-9335-00159","article-title":"The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (cadmium, heat, X-rays)","volume":"80","author":"Galan","year":"2001","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.addr.2017.01.005_bb0790","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1289\/ehp.8454153","article-title":"Histopathology of early effects of oral cadmium in the rat kidney","volume":"54","author":"Aughey","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0795","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10534-010-9328-y","article-title":"Heavy metal poisoning: the effects of cadmium on the kidney","volume":"23","author":"Johri","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.addr.2017.01.005_bb0800","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1289\/ehp.8454175","article-title":"Long-term observations on tubular and glomerular function in cadmium-exposed persons","volume":"54","author":"Piscator","year":"1984","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb0805","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0009-2797(76)90138-1","article-title":"The biosynthesis of metallothionein rat liver and kidney after administration of cadmium","volume":"15","author":"Shaikh","year":"1976","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.addr.2017.01.005_bb0810","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0014-5793(73)80764-1","article-title":"Cadmium-induced synthesis of hepatic metallothionein in chicken and rats","volume":"32","author":"Weser","year":"1973","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0815","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/15287397709529493","article-title":"Biliary excretion of cadmium in rat. I. Dose-dependent biliary excretion and the form of cadmium in the bile","volume":"2","author":"Cherian","year":"1977","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb0820","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.toxlet.2009.12.007","article-title":"Potential mechanisms involved in the absorptive transport of cadmium in isolated perfused rabbit renal proximal tubules","volume":"193","author":"Wang","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0825","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/taap.1999.8854","article-title":"Evidence for basolateral uptake of cadmium in the kidneys of rats","volume":"164","author":"Zalups","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0830","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.toxlet.2011.04.005","article-title":"Renal organic cation transporters mediated cadmium-induced nephrotoxicity","volume":"204","author":"Soodvilai","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0835","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1021\/mp400113d","article-title":"Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+","volume":"10","author":"Thevenod","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2017.01.005_bb0840","doi-asserted-by":"crossref","first-page":"F393","DOI":"10.1152\/ajprenal.00233.2003","article-title":"Megalin mediates renal uptake of heavy metal metallothionein complexes","volume":"287","author":"Klassen","year":"2004","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0845","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10534-010-9309-1","article-title":"Catch me if you can! Novel aspects of cadmium transport in mammalian cells","volume":"23","author":"Thevenod","year":"2010","journal-title":"Biometals"},{"key":"10.1016\/j.addr.2017.01.005_bb0850","doi-asserted-by":"crossref","first-page":"F562","DOI":"10.1152\/ajprenal.2001.280.4.F562","article-title":"Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule","volume":"280","author":"Christensen","year":"2001","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb0855","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/jpet.106.102574","article-title":"Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells","volume":"318","author":"Wolff","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb0860","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.taap.2004.09.007","article-title":"Molecular and ionic mimicry and the transport of toxic metals","volume":"204","author":"Bridges","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0865","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.pa.33.040193.002553","article-title":"Molecular and ionic mimicry of toxic metals","volume":"33","author":"Clarkson","year":"1993","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0870","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1039\/c2mt20024d","article-title":"Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells","volume":"4","author":"Fujishiro","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.addr.2017.01.005_bb0875","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.taap.2009.02.017","article-title":"Discovery of ZIP transporters that participate in cadmium damage to testis and kidney","volume":"238","author":"He","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0880","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0041-008X(91)90091-R","article-title":"Effect of chronic dietary zinc deficiency on cadmium toxicity and carcinogenesis in the male Wistar [Hsd: (WI)BR] rat","volume":"108","author":"Waalkes","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0885","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0016-5085(78)90138-5","article-title":"Increased dietary cadmium absorption in mice and human subjects with iron deficiency","volume":"74","author":"Flanagan","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.01.005_bb0890","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2007.10.011","article-title":"Involvement of intestinal calcium transporter 1 and metallothionein in cadmium accumulation in the liver and kidney of mice fed a low-calcium diet","volume":"176","author":"Min","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0895","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0013-9351(84)90073-2","article-title":"Organ distribution and protein binding of cadmium in autopsy material from heavy smokers","volume":"34","author":"Post","year":"1984","journal-title":"Environ. Res."},{"key":"10.1016\/j.addr.2017.01.005_bb0900","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1074\/jbc.275.3.1887","article-title":"Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis","volume":"275","author":"Thevenod","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb0905","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/taap.2002.9533","article-title":"Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK","volume":"185","author":"Endo","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0910","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tox.2004.11.015","article-title":"Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL 150","volume":"208","author":"Kimura","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb0915","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/toxsci\/kfr071","article-title":"ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport","volume":"121","author":"Lee","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb0920","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0378-4274(96)03707-1","article-title":"Comparative studies of cadmium and mercury accumulation by LLC-PK1 cells: effects of pH on uptake and efflux","volume":"87","author":"Endo","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0925","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0378-4274(98)00139-8","article-title":"pH-dependent transport of cadmium in rat renal brush border membrane vesicles: cadmium efflux via H+-antiport","volume":"99","author":"Endo","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb0930","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0300-483X(98)00133-4","article-title":"Bidirectional transport of cadmium across apical membrane of renal epithelial cell lines via H+-antiporter and inorganic anion exchanger","volume":"131","author":"Endo","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb0935","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.bcp.2010.08.019","article-title":"Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity","volume":"80","author":"Nakamura","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0940","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2016.11.007","article-title":"Multidrug and toxin extrusion proteins mediate cellular transport of cadmium","volume":"314","author":"Yang","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0945","series-title":"Toxicological Profile for Mercury","author":"ATSDR","year":"2008"},{"key":"10.1016\/j.addr.2017.01.005_bb0950","first-page":"19","article-title":"Behavior of mercury in the animal organism following inhalation","volume":"7","author":"Ashe","year":"1953","journal-title":"AMA Arch. Ind. Hyg. Occup. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb0955","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1042\/bj0990062","article-title":"Studies on the binding of mercury in tissue homogenates","volume":"99","author":"Clarkson","year":"1966","journal-title":"Biochem. J."},{"key":"10.1016\/j.addr.2017.01.005_bb0960","first-page":"162","article-title":"On the value of measuring mercury and cadmium concentration in urine","volume":"11","author":"Friberg","year":"1959","journal-title":"Prac. Lek."},{"key":"10.1016\/j.addr.2017.01.005_bb0965","first-page":"163","article-title":"Distribution of two mercury compounds in rabbits after a single subcutaneous injection; a radiometric and autoradiographic study of the distribution of mercuric chloride and phenylmercuric acetate","volume":"16","author":"Friberg","year":"1957","journal-title":"AMA Arch. Ind. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb0970","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1096\/fasebj.4.14.2227216","article-title":"Whole-body imaging of the distribution of mercury released from dental fillings into monkey tissues","volume":"4","author":"Hahn","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2017.01.005_bb0975","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00278031","article-title":"Time-dependent accumulation of inorganic mercury in subcellular fractions of kidney, liver, and brain of rats exposed to methylmercury","volume":"44","author":"Omata","year":"1980","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0980","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00333983","article-title":"The kinetics of methylmercury administered repeatedly to rats","volume":"35","author":"Magos","year":"1976","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb0985","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/00039896.1970.10667325","article-title":"Studies on the biotransformation of 203Hg-labeled methyl mercury chloride in rats","volume":"21","author":"Norseth","year":"1970","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb0990","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/0006-2952(70)90104-8","article-title":"Biotransformation of methylmercury salts in the rat studied by specific determination of inorganic mercury","volume":"19","author":"Norseth","year":"1970","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb0995","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0300-483X(93)90213-C","article-title":"Early aspects of the intrarenal distribution of mercury after the intravenous administration of mercuric chloride","volume":"79","author":"Zalups","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb1000","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/00039896.1963.10663450","article-title":"Renal uptake, excretion, and retention of mercury. I. A study in the rabbit during infusion of mercuric chloride","volume":"6","author":"Berlin","year":"1963","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb1005","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/00039896.1963.10663447","article-title":"Accumulation and retention of mercury in the mouse. I. An autoradiographic study after a single intravenous injection of mercuric chloride","volume":"6","author":"Berlin","year":"1963","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb1010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/00039896.1963.10663449","article-title":"Accumulation and retention of mercury in the mouse. III. An autoradiographic comparison of methylmercuric dicyandiamide with inorganic mercury","volume":"6","author":"Berlin","year":"1963","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.addr.2017.01.005_bb1015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF02438769","article-title":"On the localization of mercuric chloride concentration in the rat kidney","volume":"340","author":"Taugner","year":"1966","journal-title":"Virchows Arch. Pathol. Anat. Physiol. Klin. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb1020","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1749-6632.1956.tb36650.x","article-title":"A physicochemical rationale for the biological activity of mercury and its compounds","volume":"65","author":"Hughes","year":"1957","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0300-483X(92)90056-K","article-title":"Renal metallothionein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism","volume":"71","author":"Zalups","year":"1992","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb1030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0300-483X(93)90092-7","article-title":"Mercury-metallothionein and the renal accumulation and handling of mercury","volume":"83","author":"Zalups","year":"1993","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb1035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(24)38871-8","article-title":"Temporal changes in metallothionein gene transcription in rat kidney and liver: relationship to content of mercury and metallothionein protein","volume":"295","author":"Zalups","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1040","doi-asserted-by":"crossref","first-page":"26391","DOI":"10.1074\/jbc.M111.249292","article-title":"Deletion of multispecific organic anion transporter Oat1\/Slc22a6 protects against mercury-induced kidney injury","volume":"286","author":"Torres","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb1045","doi-asserted-by":"crossref","first-page":"10523","DOI":"10.3390\/ijms130810523","article-title":"Gender related differences in kidney injury induced by mercury","volume":"13","author":"Hazelhoff","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1050","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/mol.63.3.590","article-title":"Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells","volume":"63","author":"Aslamkhan","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1523-1755.2004.00726.x","article-title":"Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury","volume":"66","author":"Zalups","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb1060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0378-4274(88)90184-1","article-title":"Probenecid-induced protection against acute hexachloro-1,3-butadiene and methyl mercury toxicity to the mouse kidney","volume":"40","author":"Ban","year":"1988","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb1065","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1124\/mol.62.4.921","article-title":"Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1","volume":"62","author":"Koh","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1070","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1523-1755.2005.00585.x","article-title":"Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1","volume":"68","author":"Zalups","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb1075","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1124\/jpet.105.086645","article-title":"Transport of N-acetylcysteine S-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1","volume":"314","author":"Zalups","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1080","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1124\/jpet.105.090530","article-title":"Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters","volume":"315","author":"Zalups","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1085","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1681\/ASN.V113394","article-title":"Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule","volume":"11","author":"Cannon","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb1090","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0022-3565(24)29439-8","article-title":"Amino acid transporters involved in luminal transport of mercuric conjugates of cysteine in rabbit proximal tubule","volume":"298","author":"Cannon","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.toxlet.2012.07.003","article-title":"Luminal transport of thiol S-conjugates of methylmercury in isolated perfused rabbit renal proximal tubules","volume":"213","author":"Wang","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb1100","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/jpet.106.109371","article-title":"System b0,+ and the transport of thiol-s-conjugates of methylmercury","volume":"319","author":"Bridges","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1105","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1124\/jpet.301.2.578","article-title":"Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule","volume":"301","author":"Terlouw","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tox.2004.07.003","article-title":"Endogenous thiols and MRP transporters contribute to Hg2+ efflux in HgCl2-treated tubular MDCK cells","volume":"206","author":"Aleo","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb1115","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.taap.2010.11.015","article-title":"MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury","volume":"251","author":"Bridges","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1120","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/toxsci\/kfu171","article-title":"Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule","volume":"142","author":"Zalups","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1289\/ehp.1204951","article-title":"Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining","volume":"121","author":"Engstrom","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2017.01.005_bb1130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.taap.2015.03.027","article-title":"Toxicological significance of renal Bcrp: another potential transporter in the elimination of mercuric ions from proximal tubular cells","volume":"285","author":"Bridges","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1135","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1124\/mol.54.2.353","article-title":"Mechanisms of action of 2,3-dimercaptopropane-1-sulfonate and the transport, disposition, and toxicity of inorganic mercury in isolated perfused segments of rabbit proximal tubules","volume":"54","author":"Zalups","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1140","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/jpet.107.130708","article-title":"Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid","volume":"324","author":"Bridges","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/toxsci\/kfn107","article-title":"MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR(\u2212) and control rats exposed to thiol S-conjugates of inorganic mercury","volume":"105","author":"Bridges","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2008.11.003","article-title":"MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA","volume":"235","author":"Zalups","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073559","article-title":"Glutathione status and the renal elimination of inorganic mercury in the Mrp2(\u2212\/\u2212) mouse","volume":"8","author":"Bridges","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.01.005_bb1160","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.bi.52.070183.004141","article-title":"Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics","volume":"52","author":"Waxman","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.addr.2017.01.005_bb1165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1021\/jm00247a008","article-title":"Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-mandelamido-3-cephem-4-carboxylic acids","volume":"17","author":"Hoover","year":"1974","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb1170","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0006-2952(95)02237-6","article-title":"Cephalosporin and carbacephem nephrotoxicity. Roles of tubular cell uptake and acylating potential","volume":"51","author":"Tune","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1175","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0041-008X(66)90050-0","article-title":"Acute toxicity of cephaloridine, an antibiotic derived from cephalosporin C","volume":"8","author":"Atkinson","year":"1966","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9343(85)90097-X","article-title":"Carbapenems, a new class of beta-lactam antibiotics. Discovery and development of imipenem\/cilastatin","volume":"78","author":"Birnbaum","year":"1985","journal-title":"Am. J. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb1185","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ki.1980.177","article-title":"Mechanisms of cephalosporin nephrotoxicity: a comparison of cephaloridine and cephaloglycin","volume":"18","author":"Tune","year":"1980","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb1190","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0022-3565(25)32275-5","article-title":"Cephalosporin nephrotoxicity. Transport, cytotoxicity and mitochondrial toxicity of cephaloglycin","volume":"215","author":"Tune","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1195","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0041-008X(83)90246-6","article-title":"Lipid peroxidation: a possible mechanism of cephaloridine-induced nephrotoxicity","volume":"67","author":"Kuo","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1200","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0006-2952(89)90233-5","article-title":"Oxidative and mitochondrial toxic effects of cephalosporin antibiotics in the kidney. A comparative study of cephaloridine and cephaloglycin","volume":"38","author":"Tune","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0005-2760(85)90014-1","article-title":"Cephaloridine-induced lipid peroxidation initiated by reactive oxygen species as a possible mechanism of cephaloridine nephrotoxicity","volume":"834","author":"Cojocel","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.01.005_bb1210","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0006-2952(83)90485-9","article-title":"Carrier-mediated transport of amino-cephalosporins by brush border membrane vesicles isolated from rat kidney cortex","volume":"32","author":"Inui","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1215","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1021\/jm00217a021","article-title":"Hydrolysis of 3-chloro-3-cephems. Intramolecular nucleophilic attack in cefaclor","volume":"20","author":"Indelicato","year":"1977","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb1220","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0041-008X(66)90051-2","article-title":"Subacute toxicity of cephaloridine to various species","volume":"8","author":"Atkinson","year":"1966","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1225","first-page":"863","article-title":"Toxicity, distribution, and excretion of cephaloridine in laboratory animals","volume":"5","author":"Welles","year":"1965","journal-title":"Antimicrob. Agents Chemother. (Bethesda)"},{"key":"10.1016\/j.addr.2017.01.005_bb1230","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-3565(25)29201-1","article-title":"Effect of organic acid transport inhibitors on renal cortical uptake and proximal tubular toxicity of cephaloridine","volume":"181","author":"Tune","year":"1972","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1235","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1476-5381.1967.tb02142.x","article-title":"Nephron transport and renal tubular effects of cephaloridine in animals","volume":"30","author":"Child","year":"1967","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.addr.2017.01.005_bb1240","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1046\/j.1523-1755.1999.00789.x","article-title":"Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity","volume":"56","author":"Takeda","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb1245","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/S0024-3205(02)01500-X","article-title":"Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1","volume":"70","author":"Jung","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(03)01381-5","article-title":"Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics","volume":"465","author":"Khamdang","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1255","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1124\/dmd.108.025015","article-title":"Carnitine\/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice","volume":"37","author":"Kano","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb1260","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0041-008X(79)90078-4","article-title":"The effect of renal cation transport inhibition on cephaloridine nephrotoxicity","volume":"47","author":"Wold","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1265","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0022-3565(25)33636-0","article-title":"Effect of cephaloridine on the transport of organic ions in dog kidney plasma membrane vesicles","volume":"225","author":"Kasher","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1270","first-page":"357","article-title":"Effect of cephalosporins on organic ion transport in renal membrane vesicles from rat and rabbit kidney cortex","volume":"47","author":"Williams","year":"1985","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1275","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1124\/mol.106.031823","article-title":"Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney","volume":"71","author":"Ci","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1280","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1073\/pnas.83.21.8333","article-title":"Phosphorylation of 3\u2032-azido-3\u2032-deoxythymidine and selective interaction of the 5\u2032-triphosphate with human immunodeficiency virus reverse transcriptase","volume":"83","author":"Furman","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.01.005_bb1285","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.antiviral.2009.09.014","article-title":"Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25years after zidovudine","volume":"85","author":"Cihlar","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.addr.2017.01.005_bb1290","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/AAC.39.11.2401","article-title":"Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients","volume":"39","author":"Cundy","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2017.01.005_bb1295","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/AAC.39.6.1247","article-title":"Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients","volume":"39","author":"Cundy","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2017.01.005_bb1300","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3748\/wjg.v21.i7.2116","article-title":"Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B","volume":"21","author":"Shimizu","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2017.01.005_bb1305","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/hupa.2001.25586","article-title":"Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion","volume":"32","author":"Tanji","year":"2001","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.addr.2017.01.005_bb1310","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/mol.56.3.570","article-title":"The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1","volume":"56","author":"Cihlar","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1315","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1681\/ASN.V113383","article-title":"Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1","volume":"11","author":"Ho","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb1320","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1081\/NCN-100002341","article-title":"Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs","volume":"20","author":"Cihlar","year":"2001","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.addr.2017.01.005_bb1325","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s11095-006-9196-x","article-title":"Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2)","volume":"24","author":"Uwai","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2017.01.005_bb1330","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1124\/jpet.300.3.918","article-title":"Human organic anion transporters and human organic cation transporters mediate renal antiviral transport","volume":"300","author":"Takeda","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1335","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1124\/dmd.111.042036","article-title":"Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs","volume":"40","author":"Cheng","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2017.01.005_bb1340","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/AAC.01183-08","article-title":"Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation","volume":"53","author":"Cihlar","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2017.01.005_bb1345","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.fct.2014.09.013","article-title":"The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity","volume":"74","author":"Dkhil","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb1350","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0022-3565(24)29264-8","article-title":"Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule","volume":"299","author":"Miller","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1355","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/mol.106.028233","article-title":"Functional involvement of multidrug resistance-associated protein 4 (MRP4\/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir","volume":"71","author":"Imaoka","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1360","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/12487","article-title":"MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs","volume":"5","author":"Schuetz","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.01.005_bb1365","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1124\/mol.63.5.1094","article-title":"Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5","volume":"63","author":"Reid","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1370","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00001813-200602000-00013","article-title":"Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer","volume":"17","author":"Shord","year":"2006","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.addr.2017.01.005_bb1375","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/BF00263904","article-title":"Nonlinear renal clearance of ultrafilterable platinum in patients treated with cis-dichlorodiammineplatinum (II)","volume":"15","author":"Reece","year":"1985","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1380","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/toxsci\/47.2.181","article-title":"A transfected cell model for the renal toxin transporter, rOCT2","volume":"47","author":"Pan","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2017.01.005_bb1385","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0300-483X(00)00176-1","article-title":"Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line","volume":"146","author":"Endo","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.01.005_bb1390","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00280-002-0537-0","article-title":"Inhibition of basolateral transport and cellular accumulation of cDDP and N-acetyl-l-cysteine-cDDP by TEA and PAH in the renal proximal tubule","volume":"51","author":"Kolb","year":"2003","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1395","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1523-1755.2004.00720.x","article-title":"Nephrotoxicity of platinum complexes is related to basolateral organic cation transport","volume":"66","author":"Ludwig","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.addr.2017.01.005_bb1400","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1124\/jpet.106.110346","article-title":"Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)","volume":"319","author":"Yonezawa","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1405","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/clpt.2009.139","article-title":"Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity","volume":"86","author":"Filipski","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1410","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10157-012-0638-y","article-title":"Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events","volume":"16","author":"Iwata","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.addr.2017.01.005_bb1415","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.fct.2012.03.077","article-title":"Ameliorative effects of SLC22A2 gene polymorphism 808 G\/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients","volume":"50","author":"Zhang","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2017.01.005_bb1420","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/jcpt.12097","article-title":"Absence of effect of SLC22A2 genotype on cisplatin-induced nephrotoxicity in oesophageal cancer patients receiving cisplatin and 5-fluorouracil: report of results discordant with those of earlier studies","volume":"38","author":"Hinai","year":"2013","journal-title":"J. Clin. Pharm. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1425","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1152\/ajprenal.90545.2008","article-title":"The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity","volume":"296","author":"Pabla","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.addr.2017.01.005_bb1430","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1124\/mol.113.085068","article-title":"A re-evaluation of the role of hCTR1, the human high-affinity copper transporter, in platinum-drug entry into human cells","volume":"83","author":"Ivy","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1435","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0026-895X(24)23190-4","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.addr.2017.01.005_bb1440","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0014-5793(99)00979-5","article-title":"Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT\/MRP2)","volume":"456","author":"Kawabe","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2017.01.005_bb1445","doi-asserted-by":"crossref","first-page":"20116","DOI":"10.1016\/S0021-9258(20)80702-9","article-title":"Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance","volume":"268","author":"Ishikawa","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.01.005_bb1450","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/clpt.2011.330","article-title":"Associations between ABCC2 polymorphisms and cisplatin disposition and efficacy","volume":"91","author":"Sprowl","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2017.01.005_bb1455","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.ajpath.2014.01.025","article-title":"Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice","volume":"184","author":"Wen","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2017.01.005_bb1460","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.tibtech.2015.11.001","article-title":"Kidney-on-a-chip technology for drug-induced nephrotoxicity screening","volume":"34","author":"Wilmer","year":"2016","journal-title":"Trends Biotechnol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X17300224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X17300224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T13:45:01Z","timestamp":1749908701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X17300224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":292,"alternative-id":["S0169409X17300224"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2017.01.005","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xenobiotic transporters and kidney injury","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}