{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T16:04:30Z","timestamp":1794413070546,"version":"4.9.1"},"reference-count":329,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"am","delay-in-days":395,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NIDDK","award":["DK099558"],"award-info":[{"award-number":["DK099558"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","award":["ERC-2014-AdG-671231HEPCIR"],"award-info":[{"award-number":["ERC-2014-AdG-671231HEPCIR"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006984","name":"Irma T. Hirschl Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-16-1-0363"],"award-info":[{"award-number":["W81XWH-16-1-0363"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.addr.2017.05.007","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T05:19:19Z","timestamp":1494566359000},"page":"27-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1382,"special_numbering":"C","title":["Hepatic stellate cells as key target in liver fibrosis"],"prefix":"10.1016","volume":"121","author":[{"given":"Takaaki","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Hoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2017.05.007_bb0005","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis\u2014a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0010","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/S0140-6736(15)00128-2","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"386","author":"Collaborators","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2017.05.007_bb0015","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2017.05.007_bb0020","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJMra1504367","article-title":"Treatment of patients with cirrhosis","volume":"375","author":"Ge","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0025","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004700","article-title":"Therapy for fibrotic diseases: nearing the starting line","volume":"5","author":"Friedman","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2017.05.007_bb0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver\u2014from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024993","article-title":"Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage","volume":"6","author":"D'Ambrosio","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0050","doi-asserted-by":"crossref","first-page":"G948","DOI":"10.1152\/ajpgi.00359.2011","article-title":"Preproendothelin-1 expression is negatively regulated by IFNgamma during hepatic stellate cell activation","volume":"302","author":"Li","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2017.05.007_bb0055","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.8822.1","article-title":"Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis","volume":"5","author":"Dobie","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.addr.2017.05.007_bb0060","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1002\/hep.27606","article-title":"Cre-ativity in the liver: transgenic approaches to targeting hepatic nonparenchymal cells","volume":"61","author":"Greenhalgh","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0065","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jconrel.2012.02.011","article-title":"Drug targeting to the diseased liver","volume":"161","author":"Poelstra","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2017.05.007_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fphys.2015.00329","article-title":"Cytoglobin as a marker of hepatic stellate cell-derived myofibroblasts","volume":"6","author":"Kawada","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.addr.2017.05.007_bb0075","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gutjnl-2015-309655","article-title":"A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection","volume":"65","author":"Zhang","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0080","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.27822","article-title":"Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma","volume":"62","author":"Ji","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(87)90673-7","article-title":"Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan","volume":"161","author":"Friedman","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.addr.2017.05.007_bb0090","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hep.24508","article-title":"Cross-presentation of antigen by diverse subsets of murine liver cells","volume":"54","author":"Ebrahimkhani","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0095","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121161","article-title":"Establishment and characterization of rat portal myofibroblast cell lines","volume":"10","author":"Fausther","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0110","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3727\/000000003108747064","article-title":"Establishment of an immortalized human hepatic stellate cell line to develop antifibrotic therapies","volume":"12","author":"Shibata","year":"2003","journal-title":"Cell Transplant."},{"key":"10.1016\/j.addr.2017.05.007_bb0115","doi-asserted-by":"crossref","first-page":"33750","DOI":"10.1074\/jbc.273.50.33750","article-title":"Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9\/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury","volume":"273","author":"Kim","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056116","article-title":"Overexpression of endoglin modulates TGF-beta1-signalling pathways in a novel immortalized mouse hepatic stellate cell line","volume":"8","author":"Meurer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF02623469","article-title":"Establishment of a continuous cell line from fibrotic schistosomal granulomas in mice livers","volume":"21","author":"Borojevic","year":"1985","journal-title":"In Vitro Cell. Dev. Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb0130","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/hep.22697","article-title":"Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses","volume":"49","author":"Guo","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0135","first-page":"644","article-title":"Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6","volume":"65","author":"Greenwel","year":"1991","journal-title":"Lab. Investig."},{"key":"10.1016\/j.addr.2017.05.007_bb0140","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb0145","doi-asserted-by":"crossref","first-page":"E3297","DOI":"10.1073\/pnas.1400062111","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","author":"Iwaisako","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2006.04.014","article-title":"Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis","volume":"45","author":"Kisseleva","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0155","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jhep.2011.09.021","article-title":"The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis","volume":"56","author":"Kisseleva","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0160","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.28948","article-title":"The origin of fibrogenic myofibroblasts in fibrotic liver","volume":"65","author":"Kisseleva","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0165","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1073\/pnas.1214136110","article-title":"Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0170","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice","volume":"51","author":"Taura","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0175","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/hep.24191","article-title":"Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury","volume":"53","author":"Scholten","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0180","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/hep.24206","article-title":"Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis","volume":"53","author":"Chu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0185","first-page":"2380","article-title":"Smoothened is a master regulator of adult liver repair","volume":"123","author":"Michelotti","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-0035-1550060","article-title":"Emerging and disease-specific mechanisms of hepatic stellate cell activation","volume":"35","author":"Wallace","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb0195","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0200","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.27348","article-title":"Mouse hepatocyte overexpression of NF-kappaB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis","volume":"60","author":"Shen","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0205","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0210","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0215","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1172\/JCI62423","article-title":"Alarmins: awaiting a clinical response","volume":"122","author":"Chan","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0220","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1478-3231.2012.02802.x","article-title":"IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology","volume":"32","author":"Arshad","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb0225","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2013.07.018","article-title":"Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis","volume":"39","author":"McHedlidze","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.addr.2017.05.007_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129743","article-title":"Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation","volume":"10","author":"Lan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0235","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1053\/j.gastro.2010.05.074","article-title":"Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo","volume":"139","author":"Jiang","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0240","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1002\/hep.25938","article-title":"Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent","volume":"56","author":"Aoyama","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0245","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/hep.28493","article-title":"Keratins: biomarkers and modulators of apoptotic and necrotic cell death in the liver","volume":"64","author":"Ku","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0250","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.22193","article-title":"The role of matrix stiffness in regulating cell behavior","volume":"47","author":"Wells","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0255","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0260","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fphys.2015.00359","article-title":"Interplay of matrix stiffness and c-SRC in hepatic fibrosis","volume":"6","author":"Gortzen","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.addr.2017.05.007_bb0265","doi-asserted-by":"crossref","first-page":"21387","DOI":"10.1038\/srep21387","article-title":"Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation","volume":"6","author":"Caliari","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb0270","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1039\/C6IB00027D","article-title":"Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression","volume":"8","author":"Caliari","year":"2016","journal-title":"Integr. Biol. (Camb.)"},{"key":"10.1016\/j.addr.2017.05.007_bb0275","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb0280","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12079-011-0141-3","article-title":"CCN3\/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC","volume":"6","author":"Borkham-Kamphorst","year":"2012","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.addr.2017.05.007_bb0285","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nm.2208","article-title":"Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment","volume":"16","author":"Barry-Hamilton","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0290","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2013.12.025","article-title":"Macrophage heterogeneity in liver injury and fibrosis","volume":"60","author":"Tacke","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0295","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0300","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/hep.26754","article-title":"Macrophage plasticity and polarization in liver homeostasis and pathology","volume":"59","author":"Sica","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0305","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2013.03.020","article-title":"Non-cell-autonomous tumor suppression by p53","volume":"153","author":"Lujambio","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb0310","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075361","article-title":"Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease","volume":"8","author":"Traber","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0320","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/apt.13816","article-title":"Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo in patients having non-alcoholic steatohepatitis with advanced fibrosis","volume":"44","author":"Harrison","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2017.05.007_bb0325","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/hep.23894","article-title":"The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes","volume":"52","author":"Karlmark","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0330","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.25567","article-title":"Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis","volume":"55","author":"Pellicoro","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0335","doi-asserted-by":"crossref","first-page":"345803","DOI":"10.1155\/2011\/345803","article-title":"Role of IL-17 and Th17 cells in liver diseases","volume":"2011","author":"Hammerich","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0340","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2012.05.049","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0345","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0350","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3748\/wjg.v21.i5.1531","article-title":"Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines","volume":"21","author":"Lu","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2017.05.007_bb0355","first-page":"103","article-title":"Emerging role of interleukin 22 in hepatitis B virus infection: a double-edged sword","volume":"1","author":"Gao","year":"2013","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0360","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jhep.2013.04.011","article-title":"Intrahepatic IL-8 producing Foxp3(+)CD4(+) regulatory T cells and fibrogenesis in chronic hepatitis C","volume":"59","author":"Langhans","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0365","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/hep.26697","article-title":"Chemokine receptor CCR6-dependent accumulation of gammadelta T cells in injured liver restricts hepatic inflammation and fibrosis","volume":"59","author":"Hammerich","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0370","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI24798","article-title":"Attenuated liver fibrosis in the absence of B cells","volume":"115","author":"Novobrantseva","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0375","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/hep.27761","article-title":"Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity","volume":"61","author":"Thapa","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0380","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0385","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jhep.2016.04.020","article-title":"Interleukin-15 receptor alpha on hepatic stellate cells regulates hepatic fibrogenesis in mice","volume":"65","author":"Jiao","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0390","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jhep.2014.08.038","article-title":"Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type","volume":"62","author":"Langhans","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0395","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/gutjnl-2011-301857","article-title":"NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease","volume":"61","author":"Syn","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0400","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbadis.2012.09.008","article-title":"Natural killer and natural killer T cells in liver fibrosis","volume":"1832","author":"Gao","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb0405","doi-asserted-by":"crossref","first-page":"5226","DOI":"10.4049\/jimmunol.1202909","article-title":"Chemokine receptor CXCR6-dependent hepatic NK T cell accumulation promotes inflammation and liver fibrosis","volume":"190","author":"Wehr","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0410","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2016.07.009","article-title":"Liver sinusoidal endothelial cells: physiology and role in liver diseases","volume":"66","author":"Poisson","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0415","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2011.12.017","article-title":"Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats","volume":"142","author":"Xie","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0420","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/j.gastro.2013.11.034","article-title":"Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion","volume":"146","author":"Williams","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0425","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1172\/JCI74119","article-title":"Hepatic stellate cells contribute to progenitor cells and liver regeneration","volume":"124","author":"Kordes","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0430","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1136\/gutjnl-2013-306373","article-title":"Osteopontin induces ductular reaction contributing to liver fibrosis","volume":"63","author":"Wang","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0435","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.7150\/ijbs.16445","article-title":"Role of osteopontin in liver diseases","volume":"12","author":"Wen","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb0440","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1053\/j.gastro.2010.02.054","article-title":"Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice","volume":"138","author":"Kodama","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0445","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1136\/gutjnl-2016-312431","article-title":"Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease","volume":"66","author":"Rotman","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0450","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/hep.26695","article-title":"Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice","volume":"59","author":"De Minicis","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0455","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1096\/fj.14-259515","article-title":"Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice","volume":"29","author":"Mazagova","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2017.05.007_bb0460","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.26604","article-title":"Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice","volume":"59","author":"Tomita","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0465","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(16)30579-7","article-title":"The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013","volume":"388","author":"Stanaway","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2017.05.007_bb0470","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbrc.2013.04.098","article-title":"Hepatitis B virus e antigen induces activation of rat hepatic stellate cells","volume":"435","author":"Zan","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb0475","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/ijmm.2012.1148","article-title":"HBV promotes the proliferation of hepatic stellate cells via the PDGF-B\/PDGFR-beta signaling pathway in vitro","volume":"30","author":"Bai","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0480","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/gutjnl-2013-305634","article-title":"Human hepatic stellate cells are not permissive for hepatitis C virus entry and replication","volume":"64","author":"Florimond","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0485","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1053\/j.gastro.2003.11.018","article-title":"Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells","volume":"126","author":"Bataller","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004355","article-title":"Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition","volume":"4","author":"Battaglia","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0495","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.jhep.2013.07.036","article-title":"HCV core-mediated activation of latent TGF-beta via thrombospondin drives the crosstalk between hepatocytes and stromal environment","volume":"59","author":"Benzoubir","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056367","article-title":"Activation of TGF-beta1 promoter by hepatitis C virus-induced AP-1 and Sp1: role of TGF-beta1 in hepatic stellate cell activation and invasion","volume":"8","author":"Presser","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0505","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/hep.27328","article-title":"IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells","volume":"60","author":"Preisser","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0510","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/cid\/ciw380","article-title":"Trends in incidences and risk factors for hepatocellular carcinoma and other liver events in HIV and hepatitis C virus-coinfected individuals from 2001 to 2014: a multicohort study","volume":"63","author":"Gjaerde","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb0515","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jhep.2005.07.006","article-title":"Slower fibrosis progression in HIV\/HCV-coinfected patients with successful HIV suppression using antiretroviral therapy","volume":"44","author":"Brau","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0520","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/hep.23679","article-title":"Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV\/hepatitis C virus-induced liver fibrosis","volume":"52","author":"Tuyama","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0525","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033659","article-title":"X4 human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4","volume":"7","author":"Hong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0530","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1002\/hep.28766","article-title":"Exposure to human immunodeficiency virus\/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types","volume":"64","author":"Salloum","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0535","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature10152","article-title":"Latent TGF-beta structure and activation","volume":"474","author":"Shi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.addr.2017.05.007_bb0540","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF-beta in progression of liver disease","volume":"347","author":"Dooley","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.addr.2017.05.007_bb0545","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1073\/pnas.0832466100","article-title":"Transglutaminase 2\u2212\/\u2212 mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells","volume":"100","author":"Szondy","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0550","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jhep.2009.01.028","article-title":"Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis","volume":"50","author":"Li","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0555","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000341704","article-title":"TGF-beta signaling in onset and progression of hepatocellular carcinoma","volume":"30","author":"Meindl-Beinker","year":"2012","journal-title":"Dig. Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb0560","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.92.7.2572","article-title":"Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions","volume":"92","author":"Sanderson","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0565","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0959-8049(99)00224-5","article-title":"Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver","volume":"35","author":"Schnur","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.addr.2017.05.007_bb0570","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","article-title":"Hepatic fibrosis: concept to treatment","volume":"62","author":"Trautwein","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0575","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.taap.2014.08.006","article-title":"TGF-beta1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-beta1\/Smad pathway","volume":"280","author":"Fang","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0580","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.taap.2013.08.009","article-title":"TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways","volume":"272","author":"Fang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0585","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1872-034X.2012.00983.x","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II mediates transforming growth factor-beta-induced hepatic stellate cells proliferation but not in collagen alpha1(I) production","volume":"42","author":"An","year":"2012","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.addr.2017.05.007_bb0590","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1038\/ncomms13498","article-title":"CUG-binding protein 1 regulates HSC activation and liver fibrogenesis","volume":"7","author":"Wu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb0595","first-page":"257","article-title":"Antifibrotic activity of sorafenib in experimental hepatic fibrosis: refinement of inhibitory targets, dosing, and window of efficacy in vivo","volume":"58","author":"Hong","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb0600","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2015.01.036","article-title":"Beta-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis","volume":"63","author":"Kocabayoglu","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0605","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jhep.2006.04.010","article-title":"Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice","volume":"45","author":"Czochra","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0610","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1478-3231.2012.02806.x","article-title":"Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylate","volume":"32","author":"Kim","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb0615","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.taap.2013.11.017","article-title":"Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs","volume":"274","author":"Westra","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0620","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2010.11.035","article-title":"Inhibition of PDGF, TGF-beta, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib","volume":"55","author":"Liu","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0625","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/hep.21921","article-title":"Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats","volume":"46","author":"Tugues","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0630","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1136\/gutjnl-2014-308325","article-title":"CD248\/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism","volume":"65","author":"Wilhelm","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0635","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbamcr.2013.10.010","article-title":"The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling","volume":"1843","author":"Tibaldi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb0640","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1159\/000369746","article-title":"PTPRO-associated hepatic stellate cell activation plays a critical role in liver fibrosis","volume":"35","author":"Zhang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.addr.2017.05.007_bb0645","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1073\/pnas.0409722102","article-title":"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma","volume":"102","author":"Campbell","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb0650","article-title":"Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor","volume":"9","author":"Tsai","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0655","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10238-013-0229-6","article-title":"Inhibition of connective tissue growth factor suppresses hepatic stellate cell activation in vitro and prevents liver fibrosis in vivo","volume":"14","author":"Hao","year":"2014","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0660","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1517\/13543784.2015.997874","article-title":"Early to phase II drugs currently under investigation for the treatment of liver fibrosis","volume":"24","author":"Hauff","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.addr.2017.05.007_bb0665","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1186\/1755-1536-5-S1-S24","article-title":"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis","volume":"5","author":"Lipson","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.addr.2017.05.007_bb0670","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.26898","article-title":"Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma","volume":"59","author":"Fuchs","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0675","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ncb3031","article-title":"EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation","volume":"16","author":"Lanaya","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb0680","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/hep.21375","article-title":"Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice","volume":"44","author":"Choi","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0685","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1478-3231.2005.01142.x","article-title":"Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells","volume":"25","author":"Fukushima","year":"2005","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb0690","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.22589","article-title":"Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition","volume":"49","author":"Sohail","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0695","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0168-8278(01)00169-6","article-title":"Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells","volume":"35","author":"Murata","year":"2001","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0700","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jhep.2012.07.033","article-title":"HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects","volume":"57","author":"Klein","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0705","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1038\/ncomms12502","article-title":"PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis","volume":"7","author":"Martin","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb0710","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1128\/MCB.00049-13","article-title":"Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts","volume":"33","author":"Kim","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb0715","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/hep.27117","article-title":"Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis","volume":"60","author":"Granzow","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0720","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gutjnl-2015-309600","article-title":"Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis","volume":"66","author":"Klein","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0725","doi-asserted-by":"crossref","first-page":"249","DOI":"10.21037\/hbsn.2016.02.06","article-title":"Losartan may inhibit the progression of liver fibrosis in chronic HCV patients","volume":"5","author":"Salama","year":"2016","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.addr.2017.05.007_bb0730","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00535-015-1104-x","article-title":"Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis","volume":"51","author":"Namisaki","year":"2016","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.addr.2017.05.007_bb0735","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1038\/emboj.2011.139","article-title":"AT1R-CB(1)R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II","volume":"30","author":"Rozenfeld","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.addr.2017.05.007_bb0740","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1124\/jpet.116.234179","article-title":"Swertiamarin attenuates experimental rat hepatic fibrosis by suppressing angiotensin II-angiotensin type 1 receptor-extracellular signal-regulated kinase signaling","volume":"359","author":"Li","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2017.05.007_bb0745","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","article-title":"Wnt signaling in liver fibrosis: progress, challenges and potential directions","volume":"95","author":"Miao","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.addr.2017.05.007_bb0750","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3892\/mmr.2014.2099","article-title":"Beta-catenin is overexpressed in hepatic fibrosis and blockage of Wnt\/beta-catenin signaling inhibits hepatic stellate cell activation","volume":"9","author":"Ge","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb0755","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00263.2007","article-title":"Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis","volume":"294","author":"Cheng","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2017.05.007_bb0760","doi-asserted-by":"crossref","first-page":"10355","DOI":"10.1074\/jbc.M111.312751","article-title":"Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration","volume":"287","author":"Zhu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb0765","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.ebiom.2015.10.010","article-title":"Inhibition of cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)\/beta-catenin reduces liver fibrosis in mice","volume":"2","author":"Osawa","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.addr.2017.05.007_bb0770","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2007.12.085","article-title":"Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells","volume":"367","author":"Kordes","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb0775","doi-asserted-by":"crossref","first-page":"63767","DOI":"10.18632\/oncotarget.11654","article-title":"RSPOs facilitated HSC activation and promoted hepatic fibrogenesis","volume":"7","author":"Xinguang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2017.05.007_bb0780","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142794","article-title":"Non-canonical Wnt predominates in activated rat hepatic stellate cells, influencing HSC survival and paracrine stimulation of Kupffer cells","volume":"10","author":"Corbett","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0785","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/liv.12757","article-title":"Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis","volume":"35","author":"Chatani","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb0790","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jhep.2015.10.007","article-title":"Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model","volume":"64","author":"Chung","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0795","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1053\/j.gastro.2012.07.115","article-title":"Hedgehog controls hepatic stellate cell fate by regulating metabolism","volume":"143","author":"Chen","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0800","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00018-015-2127-4","article-title":"Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction","volume":"73","author":"Gorojankina","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb0805","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2014.11.004","article-title":"Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis","volume":"16","author":"Kramann","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb0810","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1111\/bph.13611","article-title":"Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats","volume":"173","author":"El-Agroudy","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0815","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3109\/1061186X.2012.719900","article-title":"Attenuation of early liver fibrosis by pharmacological inhibition of smoothened receptor signaling","volume":"20","author":"Pratap","year":"2012","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2017.05.007_bb0820","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070599","article-title":"Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis","volume":"8","author":"Hirsova","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb0825","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/hep.26511","article-title":"Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice","volume":"58","author":"Xie","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0830","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jhep.2013.03.032","article-title":"Cannabinoid signaling and liver therapeutics","volume":"59","author":"Mallat","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0835","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyw068","article-title":"The CB1 neutral antagonist AM4113 retains the therapeutic efficacy of the inverse agonist rimonabant for nicotine dependence and weight loss with better psychiatric tolerability","volume":"19","author":"Gueye","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0840","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2016.10.004","article-title":"Crystal structure of the human cannabinoid receptor CB1","volume":"167","author":"Hua","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb0845","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cgh.2013.05.008","article-title":"Association between a polymorphism in cannabinoid receptor 2 and severe necroinflammation in patients with chronic hepatitis C","volume":"12","author":"Coppola","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0850","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.26598","article-title":"Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver","volume":"59","author":"Guillot","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0855","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00210-015-1181-7","article-title":"Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors","volume":"389","author":"El Swefy","year":"2016","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0860","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1007\/s10620-014-3487-6","article-title":"Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo","volume":"60","author":"Tang","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb0865","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/nm.2490","article-title":"Stimulating healthy tissue regeneration by targeting the 5-HT(2)B receptor in chronic liver disease","volume":"17","author":"Ebrahimkhani","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0870","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/liv.12110","article-title":"5-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis","volume":"33","author":"Kim","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb0875","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1136\/gutjnl-2016-312729","article-title":"Gut microbiome and liver diseases","volume":"65","author":"Tilg","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb0880","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature13568","article-title":"Alterations of the human gut microbiome in liver cirrhosis","volume":"513","author":"Qin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.addr.2017.05.007_bb0885","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.4254\/wjh.v8.i32.1354","article-title":"Toll-like receptors in pathophysiology of liver diseases","volume":"8","author":"Kiziltas","year":"2016","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0890","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb0895","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ccr.2012.02.007","article-title":"Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4","volume":"21","author":"Dapito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb0900","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/hep.21867","article-title":"Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9","volume":"46","author":"Watanabe","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0905","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0910","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1053\/j.gastro.2012.07.099","article-title":"Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice","volume":"143","author":"Hartmann","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb0915","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hep.26081","article-title":"Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice","volume":"57","author":"Miura","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0920","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/hep.28644","article-title":"Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by gammadelta T cells in liver fibrosis","volume":"64","author":"Seo","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0925","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/hep.28973","article-title":"Hepatocyte autotaxin expression promotes liver fibrosis and cancer","volume":"65","author":"Kaffe","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb0930","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ccell.2016.11.004","article-title":"Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition","volume":"30","author":"Nakagawa","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb0935","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0940","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)62476-5","article-title":"The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology","volume":"166","author":"Ding","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2017.05.007_bb0945","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tem.2015.01.002","article-title":"Adipocytokines and hepatic fibrosis","volume":"26","author":"Saxena","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.addr.2017.05.007_bb0950","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/bph.12114","article-title":"The beta-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis","volume":"169","author":"Zhai","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb0955","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00109-015-1313-z","article-title":"Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells","volume":"93","author":"Dong","year":"2015","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.addr.2017.05.007_bb0960","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1074\/jbc.M114.598011","article-title":"Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion","volume":"290","author":"Ramezani-Moghadam","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb0965","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/jgh.13415","article-title":"Adiponectin regulates aquaglyceroporin expression in hepatic stellate cells altering their functional state","volume":"32","author":"Tardelli","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb0970","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1096\/fj.14-253229","article-title":"Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis","volume":"28","author":"Kumar","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2017.05.007_bb0975","doi-asserted-by":"crossref","first-page":"19445","DOI":"10.1038\/srep19445","article-title":"Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb0980","doi-asserted-by":"crossref","first-page":"983","DOI":"10.4049\/jimmunol.169.2.983","article-title":"Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells","volume":"169","author":"Lalor","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0985","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI73722","article-title":"Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis","volume":"125","author":"Weston","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2017.05.007_bb0990","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fimmu.2014.00039","article-title":"TWEAK and LTbeta signaling during chronic liver disease","volume":"5","author":"Dwyer","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb0995","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/path.4707","article-title":"Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation","volume":"239","author":"Wilhelm","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.addr.2017.05.007_bb1000","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cbin.10706","article-title":"TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence","volume":"41","author":"Zhang","year":"2017","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.addr.2017.05.007_bb1005","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1074\/jbc.M115.692244","article-title":"Sirtuin 3 (SIRT3) regulates alpha-smooth muscle actin (alpha-SMA) production through the succinate dehydrogenase-G protein-coupled receptor 91 (GPR91) pathway in hepatic stellate cells","volume":"291","author":"Li","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb1010","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jhep.2015.04.013","article-title":"Gas6\/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation","volume":"63","author":"Barcena","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1015","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2017.05.007_bb1020","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/hep.28709","article-title":"Bile acids and nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives","volume":"65","author":"Arab","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1025","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/hep.26939","article-title":"Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats","volume":"59","author":"Verbeke","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1030","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/iub.1492","article-title":"Dihydroartemisinin restricts hepatic stellate cell contraction via an FXR-S1PR2-dependent mechanism","volume":"68","author":"Xu","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.addr.2017.05.007_bb1035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/febs.13956","article-title":"Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction","volume":"284","author":"Xu","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.addr.2017.05.007_bb1040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"Suppl. 3","key":"10.1016\/j.addr.2017.05.007_bb1045","first-page":"S102","article-title":"Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation","volume":"21","author":"Tsukamoto","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1050","first-page":"305","article-title":"Peroxisome proliferator-activated receptor-gamma interrupts angiogenic signal transduction by transrepression of platelet-derived growth factor-beta receptor in hepatic stellate cells","volume":"127","author":"Zhang","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb1055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.phrs.2012.06.003","article-title":"Beta-catenin pathway is required for TGF-beta1 inhibition of PPARgamma expression in cultured hepatic stellate cells","volume":"66","author":"Qian","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1060","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcmgh.2015.07.007","article-title":"Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gamma","volume":"1","author":"Povero","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1065","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1096\/fj.14-251751","article-title":"Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor gamma","volume":"29","author":"Jiang","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2017.05.007_bb1070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mce.2010.03.005","article-title":"Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver damage","volume":"323","author":"Zhou","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.addr.2017.05.007_bb1075","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.bbadis.2014.10.001","article-title":"GATA binding protein 2 mediates leptin inhibition of PPARgamma1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation","volume":"1842","author":"Zhou","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb1080","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.ajpath.2011.02.035","article-title":"Adiponectin regulation of stellate cell activation via PPARgamma-dependent and -independent mechanisms","volume":"178","author":"Shafiei","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2017.05.007_bb1085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2014.10.055","article-title":"Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro","volume":"746","author":"Zhai","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb1090","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.92","article-title":"Activation of PPARgamma\/P53 signaling is required for curcumin to induce hepatic stellate cell senescence","volume":"7","author":"Jin","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb1095","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1100","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2016.01.038","article-title":"Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening","volume":"150","author":"Ratziu","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1053\/j.gastro.2010.11.053","article-title":"Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease","volume":"140","author":"Beaven","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2119\/molmed.2011.00243","article-title":"p38 mitogen-activated protein kinase and liver X receptor-alpha mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells","volume":"18","author":"Yan","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1115","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb1120","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ccell.2016.09.004","article-title":"p62\/SQSTM1 by binding to vitamin D receptor inhibits hepatic stellate cell activity, fibrosis, and liver cancer","volume":"30","author":"Duran","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb1125","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/gutjnl-2014-307024","article-title":"Vitamin D counteracts fibrogenic TGF-beta signalling in human hepatic stellate cells both receptor-dependently and independently","volume":"64","author":"Beilfuss","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1130","doi-asserted-by":"crossref","first-page":"14210","DOI":"10.3390\/ijms160614210","article-title":"Transcriptional factors mediating retinoic acid signals in the control of energy metabolism","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb1135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/mnfr.201300538","article-title":"Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids","volume":"58","author":"Shimizu","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00535-014-0956-9","article-title":"Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma: a randomized double-blind placebo-controlled study","volume":"50","author":"Okita","year":"2015","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.addr.2017.05.007_bb1145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/gut.45.1.134","article-title":"All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially","volume":"45","author":"Hellemans","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1150","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1478-3231.2008.01745.x","article-title":"All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production","volume":"28","author":"Hisamori","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2017.05.007_bb1155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076541","article-title":"Amplified inhibition of stellate cell activation pathways by PPAR-gamma, RAR and RXR agonists","volume":"8","author":"Sharvit","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2017.05.007_bb1160","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s10620-008-0336-5","article-title":"Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor","volume":"54","author":"Bruck","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2017.05.007_bb1165","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrd4100","article-title":"REV-ERB and ROR nuclear receptors as drug targets","volume":"13","author":"Kojetin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2017.05.007_bb1170","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/hep.27049","article-title":"Novel role of nuclear receptor Rev-erbalpha in hepatic stellate cell activation: potential therapeutic target for liver injury","volume":"59","author":"Li","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1175","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biocel.2016.11.007","article-title":"Rev-erb agonist and TGF-beta similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype","volume":"81","author":"Thomes","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb1180","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.semcdb.2016.08.015","article-title":"Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas","volume":"63","author":"Yin","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb1185","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.bbadis.2016.09.001","article-title":"Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARgamma1 expression in hepatic stellate cells","volume":"1862","author":"Qiao","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb1190","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/hep.25758","article-title":"Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans","volume":"56","author":"Pritchett","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1195","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1002\/hep.27005","article-title":"GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice","volume":"59","author":"Delgado","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1200","doi-asserted-by":"crossref","first-page":"16549","DOI":"10.1073\/pnas.0404678101","article-title":"Lhx2\u2212\/\u2212 mice develop liver fibrosis","volume":"101","author":"Wandzioch","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb1205","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jhep.2014.07.029","article-title":"Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells","volume":"62","author":"Tian","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1210","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biocel.2015.12.005","article-title":"Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-beta signaling","volume":"71","author":"Tian","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb1215","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nm.3777","article-title":"Orphan nuclear receptor NR4A1 regulates transforming growth factor-beta signaling and fibrosis","volume":"21","author":"Palumbo-Zerr","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1220","doi-asserted-by":"crossref","first-page":"33593","DOI":"10.1038\/srep33593","article-title":"Adenovirus-mediated expression of orphan nuclear receptor NR4A2 targeting hepatic stellate cell attenuates liver fibrosis in rats","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb1225","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/hep.26056","article-title":"Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury","volume":"57","author":"Ghiassi-Nejad","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1230","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2012.08.026","article-title":"The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins","volume":"58","author":"Marrone","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1235","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.7732381","article-title":"Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor","volume":"268","author":"Fernandez-Salguero","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.addr.2017.05.007_bb1240","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/hep.20004","article-title":"Reversal of liver fibrosis in aryl hydrocarbon receptor null mice by dietary vitamin A depletion","volume":"39","author":"Andreola","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1245","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tox.2016.02.001","article-title":"Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases human hepatic stellate cell activation","volume":"344-346","author":"Harvey","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.05.007_bb1250","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1038\/ncomms5451","article-title":"GIV\/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis","volume":"5","author":"Lopez-Sanchez","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb1255","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","article-title":"The Hippo pathway effector YAP controls mouse hepatic stellate cell activation","volume":"63","author":"Mannaerts","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1260","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jhep.2015.05.031","article-title":"Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease","volume":"63","author":"Machado","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1265","doi-asserted-by":"crossref","first-page":"8399","DOI":"10.1074\/jbc.M115.700088","article-title":"The role of embryonic stem cell-expressed RAS (ERAS) in the maintenance of quiescent hepatic stellate cells","volume":"291","author":"Nakhaei-Rad","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb1270","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2015-311292","article-title":"Epigenetics in liver disease: from biology to therapeutics","author":"Hardy","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1275","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jhep.2015.11.024","article-title":"Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape","volume":"64","author":"Page","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1280","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.gastro.2009.10.002","article-title":"MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis","volume":"138","author":"Mann","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1285","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.addr.2017.05.007_bb1290","doi-asserted-by":"crossref","first-page":"26729","DOI":"10.18632\/oncotarget.4925","article-title":"Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells","volume":"6","author":"El Taghdouini","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2017.05.007_bb1295","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","article-title":"DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats","volume":"264","author":"Bian","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2017.05.007_bb1300","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/hep.25754","article-title":"Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation","volume":"56","author":"Perugorria","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1305","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.27649","article-title":"Low-molecular-weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down-regulation of Delta-like1","volume":"61","author":"Pan","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1310","doi-asserted-by":"crossref","first-page":"15713","DOI":"10.1073\/pnas.1522163112","article-title":"BRD4 is a novel therapeutic target for liver fibrosis","volume":"112","author":"Ding","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb1315","article-title":"Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease","author":"Hardy","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1320","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2014.09.033","article-title":"Alcohol directly stimulates epigenetic modifications in hepatic stellate cells","volume":"62","author":"Page","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1325","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/alcalc\/agh170","article-title":"Histone h3 modifications in rat hepatic stellate cells by ethanol","volume":"40","author":"Kim","year":"2005","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.addr.2017.05.007_bb1330","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.2893","article-title":"Multigenerational epigenetic adaptation of the hepatic wound-healing response","volume":"18","author":"Zeybel","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1335","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5030038","article-title":"Hepatic stellate cells and microRNAs in pathogenesis of liver fibrosis","volume":"5","author":"Kitano","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1340","doi-asserted-by":"crossref","first-page":"81","DOI":"10.18632\/oncotarget.6447","article-title":"MicroRNA-17-5p-activated Wnt\/beta-catenin pathway contributes to the progression of liver fibrosis","volume":"7","author":"Yu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2017.05.007_bb1345","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1038\/srep11549","article-title":"Integrative miRNA and gene expression profiling analysis of human quiescent hepatic stellate cells","volume":"5","author":"Coll","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb1350","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1038\/ncomms10993","article-title":"MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression","volume":"7","author":"Hyun","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb1355","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.molimm.2016.05.018","article-title":"MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt\/beta-catenin pathway","volume":"75","author":"Zhou","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.addr.2017.05.007_bb1360","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1002\/jcp.22598","article-title":"Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-beta-induced inhibition of hepatic stellate cell proliferation","volume":"226","author":"Sekiya","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.addr.2017.05.007_bb1365","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-013-1895-0","article-title":"Participation of miR-200a in TGF-beta1-mediated hepatic stellate cell activation","volume":"388","author":"Sun","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.addr.2017.05.007_bb1370","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00011-016-1020-4","article-title":"miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1\/Notch1 signal pathway","volume":"66","author":"Yang","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1375","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.cellsig.2014.07.016","article-title":"MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis","volume":"26","author":"Yang","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.addr.2017.05.007_bb1380","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2016.06.016","article-title":"MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R","volume":"359-360","author":"Yang","year":"2016","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2017.05.007_bb1385","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.19082\/1804","article-title":"Circulating miRNAs as predictor markers for activation of hepatic stellate cells and progression of HCV-induced liver fibrosis","volume":"8","author":"El-Ahwany","year":"2016","journal-title":"Electron. Physician"},{"key":"10.1016\/j.addr.2017.05.007_bb1390","doi-asserted-by":"crossref","first-page":"34157","DOI":"10.1038\/srep34157","article-title":"Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb1395","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/1751-2980.12348","article-title":"Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure","volume":"17","author":"Wang","year":"2016","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb1400","doi-asserted-by":"crossref","first-page":"869390","DOI":"10.1155\/2014\/869390","article-title":"Autophagy: a multifaceted partner in liver fibrosis","volume":"2014","author":"Mallat","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.addr.2017.05.007_bb1405","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.jhep.2011.07.010","article-title":"A role for autophagy during hepatic stellate cell activation","volume":"55","author":"Thoen","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1410","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1053\/j.gastro.2011.12.044","article-title":"Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues","volume":"142","author":"Hernandez-Gea","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1415","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2013.02.016","article-title":"Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy","volume":"59","author":"Hernandez-Gea","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1420","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/j.gastro.2015.09.039","article-title":"Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and up-regulation of SMAD2","volume":"150","author":"Koo","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1425","doi-asserted-by":"crossref","first-page":"39342","DOI":"10.1038\/srep39342","article-title":"The XBP1 arm of the unfolded protein response induces fibrogenic activity in hepatic stellate cells through autophagy","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb1430","doi-asserted-by":"crossref","first-page":"729","DOI":"10.15252\/emmm.201505925","article-title":"Endoplasmic reticulum stress enhances fibrosis through IRE1alpha-mediated degradation of miR-150 and XBP-1 splicing","volume":"8","author":"Heindryckx","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1435","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00592-015-0763-7","article-title":"Advanced glycation end product (AGE)-induced hepatic stellate cell activation via autophagy contributes to hepatitis C-related fibrosis","volume":"52","author":"He","year":"2015","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.addr.2017.05.007_bb1440","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11010-014-2298-6","article-title":"Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy","volume":"402","author":"Zhan","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.addr.2017.05.007_bb1445","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1074\/jbc.M114.592139","article-title":"Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells","volume":"290","author":"Kawasaki","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2017.05.007_bb1450","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt1396","article-title":"Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone","volume":"26","author":"Sato","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2017.05.007_bb1455","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/hep.24200","article-title":"Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis","volume":"53","author":"Zhang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1460","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/hepr.12324","article-title":"Nogo-B: a potential indicator for hepatic cirrhosis and regulator in hepatic stellate cell activation","volume":"45","author":"Men","year":"2015","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1465","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbrc.2014.10.076","article-title":"Hypoxia-inducible factor-1alpha regulates autophagy to activate hepatic stellate cells","volume":"454","author":"Deng","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb1470","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbrc.2016.11.010","article-title":"Dimethyl alpha-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cells","volume":"481","author":"Zhao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2017.05.007_bb1475","doi-asserted-by":"crossref","first-page":"9922","DOI":"10.18632\/oncotarget.14266","article-title":"Antagonism of interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10\/STAT3-suppressed autophagy in hepatocytes","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2017.05.007_bb1480","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phrs.2016.11.040","article-title":"Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation","volume":"117","author":"Jiang","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1485","first-page":"913","article-title":"Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells","volume":"26","author":"Okuno","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1490","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/hep.27137","article-title":"Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice","volume":"60","author":"Yi","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1495","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/gut.2010.209551","article-title":"Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis","volume":"60","author":"Kluwe","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1500","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.yexcr.2016.01.012","article-title":"Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence","volume":"341","author":"Yoneda","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1505","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00109-016-1434-z","article-title":"A retinoic acid receptor beta2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease","volume":"94","author":"Trasino","year":"2016","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.addr.2017.05.007_bb1510","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1194\/jlr.M062372","article-title":"ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6","volume":"56","author":"Eichmann","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1515","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/hep.27645","article-title":"Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein","volume":"62","author":"O'Mahony","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1520","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.redox.2016.12.021","article-title":"Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell","volume":"11","author":"Zhang","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb1525","doi-asserted-by":"crossref","DOI":"10.1002\/hep.29041","article-title":"The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells","author":"Bruschi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1530","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.jhep.2015.07.034","article-title":"Ubiquitin C-terminal hydrolase 1: a novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease","volume":"63","author":"Wilson","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2017.05.007_bb1535","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/gutjnl-2014-306968","article-title":"Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease","volume":"64","author":"Arndt","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.addr.2017.05.007_bb1540","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2017.05.007_bb1545","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2017.05.007_bb1550","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2016.01.010","article-title":"Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis","volume":"18","author":"Song","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb1555","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/jhep.2003.50097","article-title":"Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype","volume":"37","author":"Schnabl","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1560","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis","volume":"134","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb1565","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbamcr.2014.01.023","article-title":"The anti-fibrotic effects of CCN1\/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-beta signaling","volume":"1843","author":"Borkham-Kamphorst","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb1570","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/labinvest.2012.106","article-title":"Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats","volume":"92","author":"Klein","year":"2012","journal-title":"Lab. Investig."},{"key":"10.1016\/j.addr.2017.05.007_bb1575","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1021\/pr3000927","article-title":"Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver","volume":"11","author":"Rashid","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.addr.2017.05.007_bb1580","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.3892\/mmr.2014.3048","article-title":"Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence","volume":"11","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.addr.2017.05.007_bb1585","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005268","article-title":"Soluble egg antigens of Schistosoma japonicum induce senescence of activated hepatic stellate cells by activation of the FoxO3a\/SKP2\/P27 pathway","volume":"10","author":"Duan","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb1590","article-title":"Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings","author":"Panebianco","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.addr.2017.05.007_bb1595","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/hep.21036","article-title":"Proteasome inhibition induces hepatic stellate cell apoptosis","volume":"43","author":"Anan","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1600","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/JLB.0309135","article-title":"Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases","volume":"86","author":"Gao","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.addr.2017.05.007_bb1605","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/hep.24395","article-title":"Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice","volume":"54","author":"Bansal","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2017.05.007_bb1610","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.bbamcr.2013.02.033","article-title":"Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases","volume":"1833","author":"Shaker","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2017.05.007_bb1615","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/CAD.0000000000000316","article-title":"Sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the JNK and Akt signaling pathways","volume":"27","author":"Hao","year":"2016","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.addr.2017.05.007_bb1620","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000444556","article-title":"Liver fibrosis: from pathogenesis to novel therapies","volume":"34","author":"Weiskirchen","year":"2016","journal-title":"Dig. Dis."},{"key":"10.1016\/j.addr.2017.05.007_bb1625","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells","volume":"329","author":"Taniguchi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.addr.2017.05.007_bb1630","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cell.2016.11.038","article-title":"Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens","volume":"167","author":"Dixit","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.addr.2017.05.007_bb1635","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2017.05.007_bb1640","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2017.07.004","article-title":"3D in vitro models of liver fibrosis","author":"van Grunsven","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2017.05.007_bb1645","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","volume":"90","author":"Crespo Yanguas","year":"2016","journal-title":"Arch. Toxicol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X17300637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X17300637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:37:52Z","timestamp":1759207072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X17300637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":329,"alternative-id":["S0169409X17300637"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2017.05.007","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic stellate cells as key target in liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2017.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}