{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:02:56Z","timestamp":1791327776925,"version":"4.3.1"},"reference-count":271,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.addr.2020.05.011","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T20:15:05Z","timestamp":1591042505000},"page":"87-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":199,"special_numbering":"C","title":["Nanoparticles for topical drug delivery: Potential for skin cancer treatment"],"prefix":"10.1016","volume":"153","author":[{"given":"Vinu","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Mitragotri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2020.05.011_bb0005","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1365-2133.2003.05554.x","article-title":"Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer)","volume":"149","author":"Katalinic","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0010","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0015","first-page":"120","article-title":"Epidemiology of skin cancer","volume":"810","author":"Leiter","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2015","key":"10.1016\/j.addr.2020.05.011_bb0020","first-page":"1081","article-title":"Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. Population","volume":"151","author":"Rogers","year":"2012","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5826\/dpc.0702a01","article-title":"Epidemiological trends in skin cancer","volume":"7","author":"Apalla","year":"2017","journal-title":"Dermatol. Practical Conceptual"},{"key":"10.1016\/j.addr.2020.05.011_bb0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2014.11.001","article-title":"Skin cancer and new treatment perspectives: a review","volume":"357","author":"Simoes","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.addr.2020.05.011_bb0035","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.mayocp.2017.02.015","article-title":"Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: a population-based study in Olmsted County, Minnesota, 2000 to 2010","volume":"92","author":"Muzic","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.addr.2020.05.011_bb0040","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1001\/archderm.138.11.1427-a","article-title":"The demographics of aging in the United States: implications for dermatology","volume":"138","author":"Kosmadaki","year":"2002","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fsc.2017.03.001","article-title":"Anatomy of the skin and the pathogenesis of nonmelanoma skin cancer","volume":"25","author":"Losquadro","year":"2017","journal-title":"Facial Plastic Surg. Clin. North America"},{"key":"10.1016\/j.addr.2020.05.011_bb0050","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archderm.140.7.837","article-title":"Nonmelanoma skin cancer mortality (1988-2000): the Rhode Island follow-back study","volume":"140","author":"Lewis","year":"2004","journal-title":"Arch. Dermatol."},{"issue":"2015","key":"10.1016\/j.addr.2020.05.011_bb0055","first-page":"183","article-title":"and 2007-2011","volume":"48","author":"Guy","year":"2002","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0060","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00403-017-1724-5","article-title":"Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: a systematic review","volume":"309","author":"Barton","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0065","series-title":"Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting, Molecules, 21","author":"Palmer","year":"2016"},{"key":"10.1016\/j.addr.2020.05.011_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2013.12.037","article-title":"Topical pharmacotherapy for skin cancer: part I. Pharmacology","volume":"70","author":"Micali","year":"2014","journal-title":"J. Am. Acad. Dermatol"},{"key":"10.1016\/j.addr.2020.05.011_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3315\/jdcr.2015.1199","article-title":"How to treat actinic keratosis? An update","volume":"9","author":"Costa","year":"2015","journal-title":"J. Dermatol. Case Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb0080","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.2147\/IJN.S46921","article-title":"How nanotechnology can enhance docetaxel therapy","volume":"8","author":"Zhang","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/clpt.2013.174","article-title":"Clinical nanomedicine: a solution to the chemotherapy conundrum in pediatric leukemia therapy","volume":"95","author":"Krishnan","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2020.05.011_bb0090","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2217\/nnm.16.9","article-title":"Recent advances in liposome surface modification for oral drug delivery","volume":"11","author":"Nguyen","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0095","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/btm2.10003","article-title":"Nanoparticles in the clinic","volume":"1","author":"Anselmo","year":"2016","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2019.01.002","article-title":"Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers","volume":"143","author":"Zhao","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/btm2.10003","article-title":"Nanoparticles in the clinic: an update","volume":"1","author":"Anselmo","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2004.06.015","article-title":"Skin penetration and distribution of polymeric nanoparticles","volume":"99","author":"Alvarez-Roman","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0115","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejpb.2006.10.019","article-title":"Nanoparticles--an efficient carrier for drug delivery into the hair follicles","volume":"66","author":"Lademann","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejpb.2008.11.001","article-title":"Follicular transport route--research progress and future perspectives","volume":"71","author":"Knorr","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.4155\/tde.14.61","article-title":"Delivery and targeting of nanoparticles into hair follicles","volume":"5","author":"Fang","year":"2014","journal-title":"Ther. Deliv."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2020.05.011_bb0130","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/S0169-409X(02)00113-8","article-title":"Drug delivery routes in skin: a novel approach","volume":"54","author":"Barry","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 Dalton rule for the skin penetration of chemical compounds and drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0140","series-title":"Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds","first-page":"263","article-title":"Drugs in topical formulations","author":"Ishii","year":"2017"},{"key":"10.1016\/j.addr.2020.05.011_bb0145","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/CCO.0b013e3283252fc5","article-title":"Indoor ultraviolet tanning and skin cancer: health risks and opportunities","volume":"21","author":"Schulman","year":"2009","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.addr.2020.05.011_bb0150","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1200\/JCO.2011.39.3652","article-title":"Use of tanning beds and incidence of skin cancer","volume":"30","author":"Zhang","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.addr.2020.05.011_bb0155","series-title":"Division of Cancer Prevention and Control, Centers for Disease Control and Prevention","author":"What Are the Risk Factors for Skin Cancer?","year":"2019"},{"key":"10.1016\/j.addr.2020.05.011_bb0160","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13555-016-0165-y","article-title":"Skin cancer: epidemiology, disease burden, pathophysiology, diagnosis, and therapeutic approaches","volume":"7","author":"Apalla","year":"2017","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.addr.2020.05.011_bb0165","first-page":"369","article-title":"Non-melanoma skin cancer, sun exposure and sun protection","volume":"150","author":"Calzavara-Pinton","year":"2015","journal-title":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia"},{"key":"10.1016\/j.addr.2020.05.011_bb0170","first-page":"651","article-title":"Development of a treatment algorithm for actinic keratoses: a European Consensus","volume":"18","author":"Stockfleth","year":"2008","journal-title":"Eur.J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jaad.2009.01.008","article-title":"Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis","volume":"60","author":"Anderson","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0180","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1440-0960.2008.00497.x","article-title":"PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study","volume":"50","author":"Siller","year":"2009","journal-title":"Australasian J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0185","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archdermatol.2009.378","article-title":"Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression","volume":"146","author":"Padilla","year":"2010","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0190","first-page":"20","article-title":"Nonsurgical innovations in the treatment of nonmelanoma skin cancer","volume":"3","author":"Amini","year":"2010","journal-title":"J. Clin. Aesth. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0195","series-title":"Updates on the Management of Non-Melanoma Skin Cancer (NMSC), Healthcare (Basel), 5","author":"Fahradyan","year":"2017"},{"key":"10.1016\/j.addr.2020.05.011_bb0200","first-page":"28","article-title":"Actinic keratosis: update on field therapy","volume":"7","author":"Goldenberg","year":"2014","journal-title":"J. Clin. Aesth. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0205","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hed.10334","article-title":"Carcinoma of the skin with perineural invasion","volume":"25","author":"Garcia-Serra","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.addr.2020.05.011_bb0210","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jaad.2005.03.023","article-title":"The incidence of major complications from Mohs micrographic surgery performed in office-based and hospital-based settings","volume":"53","author":"Kimyai-Asadi","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0215","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13555-016-0120-y","article-title":"Acute and chronic cutaneous reactions to ionizing radiation therapy","volume":"6","author":"Bray","year":"2016","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.addr.2020.05.011_bb0220","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/(SICI)1097-0142(19970615)79:12<2282::AID-CNCR2>3.0.CO;2-O","article-title":"5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges","volume":"79","author":"Peng","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.addr.2020.05.011_bb0225","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1046\/j.1365-2133.2001.04407.x","article-title":"A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolaevulinate-based photodynamic therapy alone and with prior curettage","volume":"145","author":"Soler","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0230","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF01965758","article-title":"Retinoic acid: topical treatment of senile or actinic keratoses and basal cell carcinomas","volume":"1","author":"Bollag","year":"1970","journal-title":"Agents Actions"},{"key":"10.1016\/j.addr.2020.05.011_bb0235","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1040-8428(01)00185-8","article-title":"Chemoprevention of human skin cancer","volume":"41","author":"Einspahr","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.addr.2020.05.011_bb0240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2147\/TCRM.S12498","article-title":"Diclofenac gel in the treatment of actinic keratoses","volume":"7","author":"Nelson","year":"2011","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.addr.2020.05.011_bb0245","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1590\/abd1806-4841.20131803","article-title":"Retinoids for prevention and treatment of actinic keratosis","volume":"88","author":"Ianhez","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0250","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamadermatol.2013.2766","article-title":"Long-term follow-up study of ingenol mebutate gel for the treatment of actinic keratoses","volume":"149","author":"Lebwohl","year":"2013","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0255","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fonc.2019.00260","article-title":"Skin directed therapy in cutaneous T-cell lymphoma","volume":"9","author":"Tarabadkar","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.addr.2020.05.011_bb0260","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJM200103293441306","article-title":"Cutaneous squamous-cell carcinoma","volume":"344","author":"Alam","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0265","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.2174\/1381612821666150428145216","article-title":"Nanocarriers and their actions to improve skin permeability and transdermal drug delivery","volume":"21","author":"Khan","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.addr.2020.05.011_bb0270","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/acs.molpharmaceut.8b00047","article-title":"Fluorouracil-loaded gold nanoparticles for the treatment of skin cancer: development, in vitro characterization, and in vivo evaluation in a mouse skin cancer xenograft model","volume":"15","author":"Safwat","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0275","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(93)90023-9","article-title":"The routes of penetration of ions and 5-fluorouracil across human skin and the mechanisms of action of terpene skin penetration enhancers","volume":"94","author":"Cornwell","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0280","first-page":"517","article-title":"Nanoparticles as drug carrier system of 5-fluorouracil in local treatment of patients with superficial basal cell carcinoma","volume":"10","author":"Hadjikirova","year":"2005","journal-title":"J. B.U.ON."},{"key":"10.1016\/j.addr.2020.05.011_bb0285","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijpharm.2008.05.034","article-title":"Effect of poly(amidoamine) (PAMAM) dendrimer on skin permeation of 5-fluorouracil","volume":"361","author":"Venuganti","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0290","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.carbpol.2012.07.060","article-title":"Development and evaluation of 5-fluorouracil loaded chitin nanogels for treatment of skin cancer","volume":"91","author":"Sabitha","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2020.05.011_bb0295","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1208\/s12249-015-0328-7","article-title":"Topical delivery of 5-fluorouracil from pheroid formulations and the in vitro efficacy against human melanoma","volume":"16","author":"Chinembiri","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2020.05.011_bb0300","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/CAD.0b013e328346c7d6","article-title":"Comparative study of transfersomes, liposomes, and niosomes for topical delivery of 5-fluorouracil to skin cancer cells: preparation, characterization, in-vitro release, and cytotoxicity analysis","volume":"22","author":"Alvi","year":"2011","journal-title":"Anti-Cancer Drugs"},{"key":"10.1016\/j.addr.2020.05.011_bb0305","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.4314\/tjpr.v15i11.3","article-title":"Topical nano-delivery of 5-fluorouracil: preparation and characterization of water-in-oil nanoemulsion","volume":"15","author":"Siddalingam","year":"2016","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0310","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/1871520615666150907093551","article-title":"Design, development and characterization of topical microemulsions of 5-fluorouracil for the treatment of non melanoma skin cancer and its precursor lesions","volume":"16","author":"Kumar","year":"2015","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.addr.2020.05.011_bb0315","doi-asserted-by":"crossref","first-page":"12288","DOI":"10.1038\/s41598-019-48180-7","article-title":"Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals","volume":"9","author":"Mohammad","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb0320","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1080\/10717544.2016.1194498","article-title":"5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment","volume":"23","author":"Khallaf","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2020.05.011_bb0325","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.colsurfb.2016.03.036","article-title":"Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention, colloids and surfaces","volume":"143","author":"Boakye","year":"2016","journal-title":"B, Biointerfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0330","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejpb.2016.04.023","article-title":"Development and characterization of novel 1-(1-Naphthyl)piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation","volume":"104","author":"Menezes","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0335","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2014.11.022","article-title":"Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies","volume":"89","author":"Sapino","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0340","doi-asserted-by":"crossref","first-page":"17041","DOI":"10.1039\/C9NR06303J","article-title":"Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment","volume":"11","author":"Lio","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2020.05.011_bb0345","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1021\/acsami.6b16378","article-title":"Transdermal gene delivery by functional peptide-conjugated cationic gold nanoparticle reverses the progression and metastasis of cutaneous melanoma","volume":"9","author":"Niu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0350","doi-asserted-by":"crossref","first-page":"11975","DOI":"10.1073\/pnas.1118425109","article-title":"Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation","volume":"109","author":"Zheng","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.addr.2020.05.011_bb0355","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/btm2.10092","article-title":"Biodegradable bioadhesive nanoparticle incorporation of broad-spectrum organic sunscreen agents","volume":"4","author":"Suh","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0360","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.fct.2013.09.037","article-title":"Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades","volume":"62","author":"Das","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2020.05.011_bb0365","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1468-3083.2009.03100.x","article-title":"Liposomes in dermatology today","volume":"23","author":"de Leeuw","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.addr.2020.05.011_bb0370","doi-asserted-by":"crossref","first-page":"16517","DOI":"10.1038\/s41598-017-16878-1","article-title":"Dacarbazine nanoparticle topical delivery system for the treatment of melanoma","volume":"7","author":"Hafeez","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb0375","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1038\/jid.2008.59","article-title":"Topical CpG enhances the response of murine malignant melanoma to dacarbazine","volume":"128","author":"Najar","year":"2008","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0380","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1021\/am506045k","article-title":"Radiotherapeutic bandage based on electrospun polyacrylonitrile containing holmium-166 iron garnet nanoparticles for the treatment of skin cancer","volume":"6","author":"Munaweera","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0385","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.nucmedbio.2016.02.010","article-title":"Radiotherapeutic bandage for the treatment of squamous cell carcinoma of the skin","volume":"43","author":"Koneru","year":"2016","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.addr.2020.05.011_bb0390","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0140-6736(00)04214-8","article-title":"Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group","volume":"357","author":"Yarosh","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2020.05.011_bb0395","first-page":"970","article-title":"Treatment with a novel topical nanoemulsion (NB-001) speeds time to healing of recurrent cold sores","volume":"11","author":"Kircik","year":"2012","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0400","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.2217\/fon-2017-0247","article-title":"A review of BF-200 ALA for the photodynamic treatment of mild-to-moderate actinic keratosis","volume":"13","author":"Reinhold","year":"2017","journal-title":"Future Oncol."},{"key":"10.1016\/j.addr.2020.05.011_bb0405","series-title":"Study of Topical SOR007 Ointment for Cutaneous Metastases","author":"ClinicalTrials.gov","year":"2017"},{"key":"10.1016\/j.addr.2020.05.011_bb0410","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-0781.2010.00546.x","article-title":"Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma","volume":"26","author":"Kleinpenning","year":"2010","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.addr.2020.05.011_bb0415","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1562\/2004-08-23-IR-283R1.1","article-title":"Drug delivery of aminolevulinic acid from topical formulations intended for photodynamic therapy","volume":"81","author":"Donnelly","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.addr.2020.05.011_bb0420","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1365-2133.2006.07341.x","article-title":"Heterogeneity of fluorescence in psoriasis after application of 5-aminolaevulinic acid: an immunohistochemical study","volume":"155","author":"Kleinpenning","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0425","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jaad.2007.06.031","article-title":"Fluorescence diagnosis in keratinocytic intraepidermal neoplasias","volume":"57","author":"Smits","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0430","series-title":"Transdermal and topical drug delivery : principles and practice","author":"Benson","year":"2012"},{"key":"10.1016\/j.addr.2020.05.011_bb0435","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000330721","article-title":"Full-body skin mapping for six biophysical parameters: baseline values at 16 anatomical sites in 125 human subjects","volume":"25","author":"Kleesz","year":"2012","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.addr.2020.05.011_bb0440","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nantod.2014.04.008","article-title":"Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects","volume":"9","author":"Barua","year":"2014","journal-title":"Nano Today"},{"key":"10.1016\/j.addr.2020.05.011_bb0445","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc1838","article-title":"Modelling cancer in human skin tissue","volume":"6","author":"Khavari","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.addr.2020.05.011_bb0450","first-page":"147","article-title":"Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype","volume":"3","author":"Bhat","year":"2014","journal-title":"Wiley Interdiscip. Rev. Membr. Transp. Signal."},{"key":"10.1016\/j.addr.2020.05.011_bb0455","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.4049\/jimmunol.1200598","article-title":"Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans","volume":"190","author":"Oosterhoff","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2020.05.011_bb0460","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fcimb.2017.00404","article-title":"A Novel 3D Skin Explant Model to Study Anaerobic Bacterial Infection","volume":"7","author":"Maboni","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2020.05.011_bb0465","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/DAD.0b013e3181a58234","article-title":"Viral-associated nonmelanoma skin cancers: a review","volume":"31","author":"Dubina","year":"2009","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.addr.2020.05.011_bb0470","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12094-012-0982-0","article-title":"Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials","volume":"15","author":"Severino","year":"2013","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.addr.2020.05.011_bb0475","doi-asserted-by":"crossref","first-page":"895986","DOI":"10.1155\/2014\/895986","article-title":"Drug delivery nanoparticles in skin cancers","volume":"2014","author":"Dianzani","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.addr.2020.05.011_bb0480","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2015.10.049","article-title":"Nanoparticles and nanofibers for topical drug delivery","volume":"240","author":"Goyal","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0485","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ijpharm.2017.07.078","article-title":"Broad overview of engineering of functional nanosystems for skin delivery","volume":"532","author":"Mota","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0490","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/1574891X13666180911095440","article-title":"Nano-based therapy for treatment of skin cancer","volume":"13","author":"Gilani","year":"2018","journal-title":"Recent Pat. Antiinfect. Drug Discov."},{"key":"10.1016\/j.addr.2020.05.011_bb0495","first-page":"205","article-title":"Polymeric nanoparticles-based topical delivery systems for the treatment of dermatological diseases","volume":"5","author":"Zhang","year":"2013","journal-title":"Wiley Interdisc. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb0500","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.xphs.2016.10.001","article-title":"Recent advances in lipid-based vesicles and particulate carriers for topical and transdermal application","volume":"106","author":"Jain","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0505","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1016\/j.biomaterials.2013.12.099","article-title":"The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy","volume":"35","author":"Liu","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2020.05.011_bb0510","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2014.03.006","article-title":"The role of glucose transporters in the distribution of p-aminophenyl-alpha-d-mannopyranoside modified liposomes within mice brain","volume":"182","author":"Du","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0515","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1039\/C5BM00161G","article-title":"A7RC peptide modified paclitaxel liposomes dually target breast cancer","volume":"3","author":"Cao","year":"2015","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0520","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/0024-3205(80)90268-4","article-title":"Liposomes--a selective drug delivery system for the topical route of administration. Lotion dosage form","volume":"26","author":"Mezei","year":"1980","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0525","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jconrel.2011.01.006","article-title":"Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends","volume":"152","author":"Polat","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0530","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00403-011-1166-4","article-title":"I. Dos Santos Miranda Costa, Liposomal systems as drug delivery vehicles for dermal and transdermal applications","volume":"303","author":"Pierre","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0535","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejps.2008.05.002","article-title":"Liposomes and skin: from drug delivery to model membranes","volume":"34","author":"El Maghraby","year":"2008","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0540","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jps.22513","article-title":"Decrease of liposomal size and retarding effect on fluconazole skin permeation by lysine derivatives","volume":"100","author":"Schwarz","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0545","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1248\/cpb.54.242","article-title":"Enhanced delivery of retinoic acid to skin by cationic liposomes","volume":"54","author":"Kitagawa","year":"2006","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.addr.2020.05.011_bb0550","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2147\/IJN.S150086","article-title":"Increased skin permeation efficiency of imperatorin via charged ultradeformable lipid vesicles for transdermal delivery","volume":"13","author":"Lin","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0555","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/10611860108995632","article-title":"Effect of positively and negatively charged liposomes on skin permeation of drugs","volume":"9","author":"Ogiso","year":"2001","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2020.05.011_bb0560","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijpharm.2011.03.049","article-title":"Liposome surface charge influence on skin penetration behaviour","volume":"411","author":"Gillet","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/4535790","article-title":"Effect of lipid composition on in vitro release and skin deposition of curcumin encapsulated liposomes","volume":"2016","author":"Pamunuwa","year":"2016","journal-title":"J. Nanomater."},{"key":"10.1016\/j.addr.2020.05.011_bb0570","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092978","article-title":"Microfluidic-enabled liposomes elucidate size-dependent transdermal transport","volume":"9","author":"Hood","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2020.05.011_bb0575","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.colsurfb.2018.12.031","article-title":"PEG-coated vesicles from Pluronic\/lipid mixtures for the carrying of photoactive erythrosine derivatives","volume":"175","author":"de Freitas","year":"2019","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0580","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(97)00100-4","article-title":"Proniosome based transdermal delivery of levonorgestrel for effective contraception","volume":"54","author":"Vora","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0585","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000086666","article-title":"Liposomes and niosomes as topical drug delivery systems","volume":"18","author":"Choi","year":"2005","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.addr.2020.05.011_bb0590","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/0110-5558.76435","article-title":"Niosome: a future of targeted drug delivery systems","volume":"1","author":"Kazi","year":"2010","journal-title":"J. Adv. Pharmaceut. Technol. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0595","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2133.1995.tb16940.x","article-title":"Interactions between liposomes and human stratum corneum in vitro: freeze fracture electron microscopical visualization and small angle X-ray scattering studies","volume":"132","author":"Hofland","year":"1995","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb0600","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejps.2011.04.003","article-title":"Lipid-mediated gene delivery to the skin","volume":"43","author":"Geusens","year":"2011","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0605","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3109\/10731199.2011.611476","article-title":"Effect of surfactants on the characteristics of fluconazole niosomes for enhanced cutaneous delivery","volume":"39","author":"Gupta","year":"2011","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.addr.2020.05.011_bb0610","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/03639040802498864","article-title":"Development of naftifine hydrochloride alcohol-free niosome gel","volume":"35","author":"Barakat","year":"2009","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0615","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3109\/08982101003596125","article-title":"Development and characterization of effective topical liposomal system for localized treatment of cutaneous candidiasis","volume":"20","author":"Gupta","year":"2010","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0620","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3109\/03639040903585150","article-title":"Studies on nonionic surfactant bilayer vesicles of ciclopirox olamine","volume":"36","author":"Shaikh","year":"2010","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0625","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0005-2760(96)00126-9","article-title":"Interaction of liposomes with human skin in vitro--the influence of lipid composition and structure","volume":"1304","author":"Kirjavainen","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2020.05.011_bb0630","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0928-0987(98)00037-2","article-title":"Liposome-skin interactions and their effects on the skin permeation of drugs","volume":"7","author":"Kirjavainen","year":"1999","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0635","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ddtec.2005.05.003","article-title":"Vesicles as a tool for transdermal and dermal delivery","volume":"2","author":"Honeywell-Nguyen","year":"2005","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.addr.2020.05.011_bb0640","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/17425247.5.7.737","article-title":"Colloidal carriers for the enhanced delivery through the skin","volume":"5","author":"Cosco","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2020.05.011_bb0645","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0005-2736(92)90154-E","article-title":"Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force","volume":"1104","author":"Cevc","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2020.05.011_bb0650","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fphar.2015.00219","article-title":"Lipid-based nano-delivery systems for skin delivery of drugs and bioactives","volume":"6","author":"Hua","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.addr.2020.05.011_bb0655","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/187221108783331375","article-title":"Liposomal formulation for dermal and transdermal drug delivery: past, present and future","volume":"2","author":"Nounou","year":"2008","journal-title":"Recent patents on drug delivery & formulation"},{"key":"10.1016\/j.addr.2020.05.011_bb0660","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.2147\/IJN.S86186","article-title":"Development, characterization, and skin delivery studies of related ultradeformable vesicles: transfersomes, ethosomes, and transethosomes","volume":"10","author":"Ascenso","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0665","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0168-3659(99)00222-9","article-title":"Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties","volume":"65","author":"Touitou","year":"2000","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0670","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v20.i1.20","article-title":"Ethosomes: new prospects in transdermal delivery","volume":"20","author":"Godin","year":"2003","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2020.05.011_bb0675","first-page":"368","article-title":"Ethosomes: a novel delivery system for antifungal drugs in the treatment of topical fungal diseases","volume":"47","author":"Bhalaria","year":"2009","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.addr.2020.05.011_bb0680","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijpharm.2008.01.020","article-title":"Comparison of 5-aminolevulinic acid-encapsulated liposome versus ethosome for skin delivery for photodynamic therapy","volume":"356","author":"Fang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0685","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.colsurfb.2011.12.004","article-title":"A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro\/in vivo evaluation","volume":"92","author":"Song","year":"2012","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0690","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpharm.2004.02.032","article-title":"Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery","volume":"278","author":"Souto","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0695","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.chemphyslip.2012.01.006","article-title":"Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis","volume":"165","author":"Gupta","year":"2012","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.addr.2020.05.011_bb0700","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/157016311796799062","article-title":"20 years of lipid nanoparticles (SLN and NLC): present state of development and industrial applications","volume":"8","author":"Muller","year":"2011","journal-title":"Curr. Drug Discovery Technol."},{"key":"10.1016\/j.addr.2020.05.011_bb0705","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/0250-474X.57282","article-title":"Solid lipid nanoparticles: a modern formulation approach in drug delivery system","volume":"71","author":"Mukherjee","year":"2009","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0710","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-511X-8-6","article-title":"Lipid nanoparticles for transdermal delivery of flurbiprofen: formulation, in vitro, ex vivo and in vivo studies","volume":"8","author":"Bhaskar","year":"2009","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.addr.2020.05.011_bb0715","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1002\/jps.24152","article-title":"An in vitro and in vivo comparison of solid and liquid-oil cores in transdermal aconitine nanocarriers","volume":"103","author":"Zhang","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0720","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0939-6411(03)00040-7","article-title":"The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study","volume":"56","author":"Wissing","year":"2003","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0725","first-page":"4409","article-title":"Development of terbinafine solid lipid nanoparticles as a topical delivery system","volume":"7","author":"Chen","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0730","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1211\/jpp.59.8.0002","article-title":"Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in-vitro characterization, ex-vivo and in-vivo studies","volume":"59","author":"Sanna","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2020.05.011_bb0735","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1208\/s12249-009-9199-0","article-title":"Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery","volume":"10","author":"Bhalekar","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2020.05.011_bb0740","first-page":"131","article-title":"Design and evaluation of itraconazole loaded solid lipid nanoparticulate system for improving the antifungal therapy","volume":"22","author":"Mukherjee","year":"2009","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0745","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/09687688.2010.522203","article-title":"Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery","volume":"27","author":"Desai","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.addr.2020.05.011_bb0750","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.addr.2003.12.002","article-title":"Solid lipid nanoparticles for parenteral drug delivery","volume":"56","author":"Wissing","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb0755","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-5173(02)00080-7","article-title":"Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin","volume":"238","author":"Cavalli","year":"2002","journal-title":"Int. J. Pharm."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2020.05.011_bb0760","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/S0169-409X(02)00118-7","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations","volume":"54","author":"Muller","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb0765","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12951-018-0389-3","article-title":"Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties","volume":"16","author":"Gu","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.addr.2020.05.011_bb0770","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/NSA.S19419","article-title":"Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness","volume":"4","author":"Smijs","year":"2011","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.addr.2020.05.011_bb0775","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1016\/j.biomaterials.2010.03.010","article-title":"Translocation of cell penetrating peptide engrafted nanoparticles across skin layers","volume":"31","author":"Patlolla","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2020.05.011_bb0780","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s11095-012-0789-2","article-title":"Dermal microdialysis technique to evaluate the trafficking of surface-modified lipid nanoparticles upon topical application","volume":"29","author":"Desai","year":"2012","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0785","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jconrel.2012.05.011","article-title":"Enhanced skin permeation using polyarginine modified nanostructured lipid carriers","volume":"161","author":"Shah","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0790","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-006-9132-0","article-title":"Micellar nanocarriers: pharmaceutical perspectives","volume":"24","author":"Torchilin","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0795","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2011.03.003","article-title":"Novel micelle formulations to increase cutaneous bioavailability of azole antifungals","volume":"153","author":"Bachhav","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0800","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1211\/jpp.61.12.0004","article-title":"Chitosan-tripolyphosphate nanoparticles as a possible skin drug delivery system for aciclovir with enhanced stability","volume":"61","author":"Hasanovic","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2020.05.011_bb0805","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpharm.2013.01.024","article-title":"Self-assembled polymeric nanoparticles for percutaneous co-delivery of hydrocortisone\/hydroxytyrosol: an ex vivo and in vivo study using an NC\/Nga mouse model","volume":"444","author":"Hussain","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0810","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijpharm.2016.05.005","article-title":"In-vivo dermal pharmacokinetics, efficacy, and safety of skin targeting nanoparticles for corticosteroid treatment of atopic dermatitis","volume":"507","author":"Siddique","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0815","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1039\/C6MD00502K","article-title":"Chitosan nanoparticles for nitric oxide delivery in human skin","volume":"8","author":"Pelegrino","year":"2017","journal-title":"MedChemComm"},{"key":"10.1016\/j.addr.2020.05.011_bb0820","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.3390\/ijms11125152","article-title":"Applications of chitin and its derivatives in biological medicine","volume":"11","author":"Park","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0825","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijpharm.2006.03.040","article-title":"Retinol-encapsulated low molecular water-soluble chitosan nanoparticles","volume":"319","author":"Kim","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0830","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3923\/pjbs.2013.601.609","article-title":"Biocompatible nanoparticles for sustained topical delivery of anticancer phytoconstituent quercetin","volume":"16","author":"Sahu","year":"2013","journal-title":"Pakistan J. Biol. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0835","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jconrel.2017.03.385","article-title":"Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel","volume":"254","author":"Sun","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0840","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0939-6411(01)00188-6","article-title":"Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection","volume":"52","author":"Alvarez-Roman","year":"2001","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0845","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1021\/bm060860t","article-title":"Effect of tyrosine-derived triblock copolymer compositions on nanosphere self-assembly and drug delivery","volume":"8","author":"Sheihet","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.addr.2020.05.011_bb0850","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijpharm.2016.10.072","article-title":"Polymeric nanospheres for topical delivery of vitamin D3","volume":"516","author":"Ramezanli","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0855","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/btm2.10094","article-title":"Scalable synthesis and validation of PAMAM dendrimer-N-acetyl cysteine conjugate for potential translation","volume":"3","author":"Sharma","year":"2018","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb0860","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejpb.2008.09.023","article-title":"Dendrimers as versatile platform in drug delivery applications","volume":"71","author":"Svenson","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0865","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2147\/RRTD.S32621","article-title":"Nanocarriers for transdermal drug delivery","volume":"2012","author":"Escobar-Ch\u00e1vez","year":"2012","journal-title":"Res. Rep. Transdermal Drug Delivery"},{"key":"10.1016\/j.addr.2020.05.011_bb0870","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/jps.21603","article-title":"Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration","volume":"98","author":"Venuganti","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0875","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1007\/s11095-011-0455-0","article-title":"Structure-skin permeability relationship of dendrimers","volume":"28","author":"Venuganti","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb0880","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jps.20745","article-title":"Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers","volume":"96","author":"Cheng","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0885","article-title":"The role of dendrimers in topical drug delivery","volume":"32","author":"Editors","year":"2008","journal-title":"Pharm. Technol."},{"key":"10.1016\/j.addr.2020.05.011_bb0890","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1002\/anie.200900441","article-title":"Nanogels as pharmaceutical carriers: finite networks of infinite capabilities","volume":"48","author":"Kabanov","year":"2009","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.addr.2020.05.011_bb0895","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijpharm.2010.08.011","article-title":"Nanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skin","volume":"401","author":"Samah","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0900","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.2174\/0929867311209025029","article-title":"Functional nanogels for biomedical applications","volume":"19","author":"Asadian-Birjand","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.addr.2020.05.011_bb0905","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1039\/C5PY00924C","article-title":"Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration","volume":"6","author":"Asadian-Birjand","year":"2015","journal-title":"Polym. Chem."},{"key":"10.1016\/j.addr.2020.05.011_bb0910","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.nano.2015.02.017","article-title":"Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules","volume":"11","author":"Witting","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0915","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jconrel.2016.02.047","article-title":"Effects of thermoresponsivity and softness on skin penetration and cellular uptake of polyglycerol-based nanogels","volume":"228","author":"Rancan","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0920","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1039\/C6NR06435C","article-title":"Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle","volume":"9","author":"Sahle","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2020.05.011_bb0925","doi-asserted-by":"crossref","first-page":"450","DOI":"10.7150\/thno.21668","article-title":"Breaking the barrier - potent anti-inflammatory activity following efficient topical delivery of etanercept using thermoresponsive nanogels","volume":"8","author":"Giulbudagian","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2020.05.011_bb0930","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jconrel.2017.03.023","article-title":"Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: in vitro and ex vivo studies","volume":"253","author":"Sahu","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb0935","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.colsurfb.2018.11.018","article-title":"pH responsive 5-fluorouracil loaded biocompatible nanogels for topical chemotherapy of aggressive melanoma","volume":"174","author":"Sahu","year":"2019","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb0940","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejpb.2016.06.019","article-title":"Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis","volume":"107","author":"Divya","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0945","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ijpharm.2013.05.042","article-title":"Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc)","volume":"453","author":"Abu Samah","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0950","series-title":"Micro- and Nanotechnology in Vaccine Development","first-page":"327","article-title":"Chapter seventeen - Nano- and microtechnology in skin delivery of vaccines","author":"Dang","year":"2017"},{"key":"10.1016\/j.addr.2020.05.011_bb0955","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0378-5173(99)00055-1","article-title":"Effect of ethanol\/propylene glycol on the in vitro percutaneous absorption of aspirin, biophysical changes and macroscopic barrier properties of the skin","volume":"181","author":"Levang","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0960","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5173(00)00490-7","article-title":"Combined effect of oleic acid and polyethylene glycol 200 on buccal permeation of [D-ala2, D-leu5]enkephalin from a cubic phase of glyceryl monooleate","volume":"204","author":"Lee","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb0965","first-page":"1867","article-title":"Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate","volume":"11","author":"Hsiao","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb0970","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-42047-7","article-title":"Preferential accumulation of phospholipid-PEG and cholesterol-PEG decorated gold nanorods into human skin layers and their photothermal-based antibacterial activity","volume":"9","author":"Mahmoud","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb0975","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jcis.2006.07.055","article-title":"Formation and stability of paraffin oil-in-water nano-emulsions prepared by the emulsion inversion point method","volume":"303","author":"Liu","year":"2006","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0980","doi-asserted-by":"crossref","DOI":"10.1208\/pt0804104","article-title":"Nanoemulsions as vehicles for transdermal delivery of aceclofenac","volume":"8","author":"Shakeel","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2020.05.011_bb0985","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cis.2003.10.023","article-title":"Formation and stability of nano-emulsions","volume":"108-109","author":"Tadros","year":"2004","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0990","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cocis.2005.06.004","article-title":"Nano-emulsions","volume":"10","author":"Solans","year":"2005","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb0995","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4155\/ppa.13.79","article-title":"Pharmaceutical and biomedical applications of lipid-based nanocarriers","volume":"3","author":"Carbone","year":"2014","journal-title":"Pharmaceutical Patent Analyst"},{"key":"10.1016\/j.addr.2020.05.011_bb1000","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/ics.12260","article-title":"Nanoemulsion: process selection and application in cosmetics--a review","volume":"38","author":"Yukuyama","year":"2016","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13205-014-0214-0","article-title":"Nanoemulsion: an advanced mode of drug delivery system","volume":"5","author":"Jaiswal","year":"2015","journal-title":"3 Biotech"},{"key":"10.1016\/j.addr.2020.05.011_bb1010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijpharm.2004.05.016","article-title":"Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation","volume":"280","author":"Bouchemal","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1015","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0168-3659(03)00342-0","article-title":"Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer","volume":"92","author":"Verreck","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1020","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.biotechadv.2010.01.004","article-title":"Electrospinning: a fascinating fiber fabrication technique","volume":"28","author":"Bhardwaj","year":"2010","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.addr.2020.05.011_bb1025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1163\/156856204322977184","article-title":"Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)\/poly(ethylene glycol)-g-chitosan electrospun membranes","volume":"15","author":"Jiang","year":"2004","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.addr.2020.05.011_bb1030","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1517\/14712598.4.5.659","article-title":"Development of novel tissue engineering scaffolds via electrospinning","volume":"4","author":"Nair","year":"2004","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.addr.2020.05.011_bb1035","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jconrel.2012.04.035","article-title":"Ultrafast and fast bioerodible electrospun fiber mats for topical delivery of a hydrophilic peptide","volume":"161","author":"Macri","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1040","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1021\/acsami.6b15914","article-title":"Transdermal vascular endothelial growth factor delivery with surface engineered gold nanoparticles","volume":"9","author":"Chen","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2020.05.011_bb1045","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.yrtph.2018.04.006","article-title":"In vitro percutaneous penetration of silver nanoparticles in pig and human skin","volume":"95","author":"Kraeling","year":"2018","journal-title":"Regulatory Toxicol. Pharmacol."},{"key":"10.1016\/j.addr.2020.05.011_bb1050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jconrel.2015.03.004","article-title":"Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: nanotechnology from the bench to clinic","volume":"206","author":"Paithankar","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejpb.2016.04.022","article-title":"Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment","volume":"104","author":"Leite-Silva","year":"2016","journal-title":"Eur. J. Pharmaceut. Biopharmaceut."},{"key":"10.1016\/j.addr.2020.05.011_bb1060","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jid.2018.08.024","article-title":"Support for the safe use of zinc oxide nanoparticle sunscreens: lack of skin penetration or cellular toxicity after repeated application in volunteers","volume":"139","author":"Mohammed","year":"2019","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1065","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10717540500455975","article-title":"Dermal and transdermal drug delivery systems: current and future prospects","volume":"13","author":"Brown","year":"2006","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2020.05.011_bb1070","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12272-010-0301-7","article-title":"Recent advances in transdermal drug delivery","volume":"33","author":"Subedi","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb1075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-3495(66)86636-5","article-title":"Analysis of permeability data for the case of parallel diffusion pathways","volume":"6","author":"Scheuplein","year":"1966","journal-title":"Biophys. J."},{"key":"10.1016\/j.addr.2020.05.011_bb1080","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.addr.2007.07.004","article-title":"Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models","volume":"59","author":"Godin","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb1085","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1152\/physrev.1971.51.4.702","article-title":"Permeability of the skin","volume":"51","author":"Scheuplein","year":"1971","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2020.05.011_bb1090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1016250422596","article-title":"Transfollicular drug delivery","volume":"12","author":"Lauer","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb1095","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1002\/jps.10483","article-title":"Mobility of water in human stratum corneum","volume":"92","author":"Kasting","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1100","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000093119","article-title":"Hair follicles - a long-term reservoir for drug delivery","volume":"19","author":"Lademann","year":"2006","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.addr.2020.05.011_bb1105","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jps.2600800505","article-title":"Follicles play an important role in percutaneous absorption","volume":"80","author":"Illel","year":"1991","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1211\/jpp.60.2.0002","article-title":"In-vitro permeation of drugs into porcine hair follicles: is it quantitatively equivalent to permeation into human hair follicles?","volume":"60","author":"Frum","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2020.05.011_bb1115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jconrel.2010.11.015","article-title":"Selective follicular targeting by modification of the particle sizes","volume":"150","author":"Patzelt","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1120","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1248\/bpb.33.1394","article-title":"Permeation pathway of macromolecules and nanospheres through skin","volume":"33","author":"Todo","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2020.05.011_bb1125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/17425247.2014.875528","article-title":"Skin permeabilization for transdermal drug delivery: recent advances and future prospects","volume":"11","author":"Schoellhammer","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2020.05.011_bb1130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/pharmaceutics7040438","article-title":"Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum","volume":"7","author":"Alkilani","year":"2015","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2020.05.011_bb1135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.01.019","article-title":"Breaching the skin barrier through temperature modulations","volume":"202","author":"Shahzad","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijpharm.2018.11.032","article-title":"Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases","volume":"555","author":"Carter","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1145","series-title":"Drugs\u2014 Cosmetics\u2014Mechanisms\u2014Methodology","first-page":"515","article-title":"Stratum corneum and barrier performance: A model lamellar structural approach","author":"Moghimi","year":"1999"},{"key":"10.1016\/j.addr.2020.05.011_bb1150","series-title":"Dermatological and Transdermal Formulations","first-page":"89","article-title":"Skin transport","author":"Roberts","year":"2002"},{"key":"10.1016\/j.addr.2020.05.011_bb1155","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/sj.jid.5700733","article-title":"Penetration of metallic nanoparticles in human full-thickness skin","volume":"127","author":"Baroli","year":"2007","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1160","doi-asserted-by":"crossref","first-page":"16908","DOI":"10.1038\/srep16908","article-title":"Shape-Dependent Skin Penetration of Silver Nanoparticles: Does It Really Matter?","volume":"5","author":"Tak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb1165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2008.11.014","article-title":"Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation","volume":"370","author":"Hoeller","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpharm.2003.10.038","article-title":"Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge","volume":"275","author":"Kohli","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1175","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/jps.20352","article-title":"Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification-diffusion technique: penetration across the stratum corneum","volume":"94","author":"Olvera-Martinez","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0005-2736(99)00176-5","article-title":"Interactions of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy","volume":"1461","author":"van den Bergh","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2020.05.011_bb1185","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.0022-202X.2004.23441.x","article-title":"Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo","volume":"123","author":"Honeywell-Nguyen","year":"2004","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1190","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/17435390.2011.569092","article-title":"Quantum dot penetration into viable human skin","volume":"6","author":"Prow","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.addr.2020.05.011_bb1195","first-page":"31","article-title":"The effect of heat, pH and organic solvents on the electrical impedance and permeability of excised human skin","volume":"82","author":"A. A.C., F. J., S. C., T. T.F.S","year":"1969","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1200","doi-asserted-by":"crossref","first-page":"E167","DOI":"10.1208\/pt060225","article-title":"The effect of pH and organic ester penetration enhancers on skin permeation kinetics of terbutaline sulfate from pseudolatex-type transdermal delivery systems through mouse and human cadaver skins","volume":"6","author":"Panigrahi","year":"2005","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2020.05.011_bb1205","first-page":"276","article-title":"Transdermal drug delivery: the inherent challenges and technological advancements","volume":"6","author":"Ahad","year":"2010","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1210","series-title":"Dermatology","author":"Bolognia","year":"2012"},{"key":"10.1016\/j.addr.2020.05.011_bb1215","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pharep.2018.10.008","article-title":"Nanostructured lipid carriers: A potential use for skin drug delivery systems","volume":"71","author":"Czajkowska-Kosnik","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.addr.2020.05.011_bb1220","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ejpb.2014.12.020","article-title":"Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: a review","volume":"89","author":"Han","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/03639045.2013.828219","article-title":"Recent advances in gel technologies for topical and transdermal drug delivery","volume":"40","author":"Rehman","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1230","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/btm2.10098","article-title":"Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques","volume":"3","author":"Perez Cuevas","year":"2018","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb1235","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.2174\/092986712803306358","article-title":"Transdermal drug delivery in vitro using diffusion cells","volume":"19","author":"Bartosova","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.addr.2020.05.011_bb1240","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2016.04.030","article-title":"Chemical penetration enhancers in stratum corneum - Relation between molecular effects and barrier function","volume":"232","author":"Pham","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1245","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/1566523217666170510151540","article-title":"Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery","volume":"17","author":"Amjadi","year":"2017","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.addr.2020.05.011_bb1250","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/btm2.10083","article-title":"Ionic liquids for addressing unmet needs in healthcare","volume":"3","author":"Agatemor","year":"2018","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2020.05.011_bb1255","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00403-011-1163-7","article-title":"Nanoparticles in dermatology","volume":"303","author":"Papakostas","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.addr.2020.05.011_bb1260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2010.11.003","article-title":"Potentials of new nanocarriers for dermal and transdermal drug delivery","volume":"77","author":"Neubert","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1265","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1467-2494.1997.tb00175.x","article-title":"Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum","volume":"19","author":"Dussert","year":"1997","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1270","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000066249","article-title":"Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice","volume":"12","author":"Lademann","year":"1999","journal-title":"Skin Pharmacol. Appl. Ski. Physiol."},{"key":"10.1016\/j.addr.2020.05.011_bb1275","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000098701","article-title":"Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation","volume":"20","author":"Cross","year":"2007","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.addr.2020.05.011_bb1280","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.tiv.2005.08.008","article-title":"The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin","volume":"20","author":"Gamer","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.addr.2020.05.011_bb1285","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1038\/sj.jid.5700374","article-title":"Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs","volume":"126","author":"Stracke","year":"2006","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1290","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tox.2008.09.025","article-title":"Human skin penetration of silver nanoparticles through intact and damaged skin","volume":"255","author":"Larese","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2020.05.011_bb1295","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1289\/ehp.5999","article-title":"Skin as a route of exposure and sensitization in chronic beryllium disease","volume":"111","author":"Tinkle","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2020.05.011_bb1300","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-5173(01)00811-0","article-title":"PLGA microparticles: possible vehicles for topical drug delivery","volume":"226","author":"de Jalon","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1305","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1242\/jcs.94.2.175","article-title":"Confocal scanning optical microscopy and its applications for biological specimens","volume":"94","author":"Shotton","year":"1989","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.addr.2020.05.011_bb1310","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1021\/mp9001188","article-title":"Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin","volume":"6","author":"Wu","year":"2009","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1315","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2012.06.024","article-title":"Objective assessment of nanoparticle disposition in mammalian skin after topical exposure","volume":"162","author":"Campbell","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1320","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejpb.2008.02.024","article-title":"Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo","volume":"70","author":"Patzelt","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1325","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2014.01.018","article-title":"Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm","volume":"179","author":"Raber","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1330","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2016.09.015","article-title":"Do nanoparticles have a future in dermal drug delivery?","volume":"246","author":"Patzelt","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2020.05.011_bb1335","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/sj.jid.5700226","article-title":"40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin","volume":"126","author":"Vogt","year":"2006","journal-title":"J. Inves. Dermatol."},{"key":"10.1016\/j.addr.2020.05.011_bb1340","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nano.2012.04.004","article-title":"Interaction of inorganic nanoparticles with the skin barrier: current status and critical review","volume":"9","author":"Labouta","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2020.05.011_bb1345","doi-asserted-by":"crossref","DOI":"10.1117\/1.3078813","article-title":"Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles","volume":"14","author":"Lademann","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.addr.2020.05.011_bb1350","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpb.2016.10.005","article-title":"Ratchet effect for nanoparticle transport in hair follicles","volume":"116","author":"Radtke","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2020.05.011_bb1355","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nbt920","article-title":"Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping","volume":"22","author":"Kim","year":"2004","journal-title":"Nat. Biotechnol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X20300442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X20300442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:49:07Z","timestamp":1759207747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X20300442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":271,"alternative-id":["S0169409X20300442"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2020.05.011","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanoparticles for topical drug delivery: Potential for skin cancer treatment","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2020.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}