{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T14:04:13Z","timestamp":1794060253570,"version":"4.8.0"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur Le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-18-CE14-0006-01"],"award-info":[{"award-number":["ANR-18-CE14-0006-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016944","name":"Regenerative Medicine Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016944","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.addr.2021.05.026","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T23:03:11Z","timestamp":1622588591000},"page":"113816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"special_numbering":"C","title":["Role of extracellular vesicles in liver diseases and their therapeutic potential"],"prefix":"10.1016","volume":"175","author":[{"given":"Enis","family":"Kostallari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-2104","authenticated-orcid":false,"given":"Shantha","family":"Valainathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-6543","authenticated-orcid":false,"given":"Louise","family":"Biquard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-1859","authenticated-orcid":false,"given":"Pierre-Emmanuel","family":"Rautou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.addr.2021.05.026_b0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/liv.13682","article-title":"Liver diseases: a major, neglected global public health problem requiring urgent actions and large-scale screening","volume":"38","author":"Marcellin","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.addr.2021.05.026_b0010","doi-asserted-by":"crossref","unstructured":"J.M. Paik, P. Golabi, Y. Younossi, A. Mishra, Z.M. Younossi, Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of NAFLD, Hepatology, 72 (2020) 1605-1616.","DOI":"10.1002\/hep.31173"},{"key":"10.1016\/j.addr.2021.05.026_b0015","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal","year":"2010","journal-title":"Lancet"},{"issue":"2018","key":"10.1016\/j.addr.2021.05.026_b0025","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles, (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Thery","year":"2018","journal-title":"J. Extracell Vesicles"},{"key":"10.1016\/j.addr.2021.05.026_b0030","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jhep.2020.07.014","article-title":"Extracellular vesicles as biomarkers in liver diseases: a clinician's point of view","volume":"73","author":"Thietart","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2018.02.002","article-title":"Subpopulations of extracellular vesicles and their therapeutic potential","volume":"60","author":"Lasser","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.addr.2021.05.026_b0040","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.addr.2021.05.026_b0045","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jhep.2019.01.030","article-title":"Extracellular vesicles, the liquid biopsy of the future","volume":"70","author":"Eguchi","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0050","doi-asserted-by":"crossref","first-page":"G739","DOI":"10.1152\/ajpgi.00183.2019","article-title":"Emerging role of extracellular vesicles in liver diseases","volume":"317","author":"Malhi","year":"2019","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"10.1016\/j.addr.2021.05.026_b0055","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.28838","article-title":"Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood","volume":"65","author":"Eguchi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0060","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nrgastro.2014.7","article-title":"The emerging roles of microvesicles in liver diseases","volume":"11","author":"Lemoinne","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","article-title":"Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles","volume":"64","author":"Verma","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0075","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/s41467-018-04470-8","article-title":"Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy","volume":"9","author":"You","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0080","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1053\/j.gastro.2020.06.031","article-title":"IRE1A Stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis","volume":"159","author":"Dasgupta","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0085","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.28785","article-title":"The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0090","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0095","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/hep.28709","article-title":"Bile acids and nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives","volume":"65","author":"Arab","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0100","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"150","author":"Machado","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0105","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0110","doi-asserted-by":"crossref","unstructured":"T.G. Cotter, M. Rinella, Nonalcoholic Fatty Liver Disease 2020: The State of the Disease, Gastroenterology, 158 (2020) 1851-1864.","DOI":"10.1053\/j.gastro.2020.01.052"},{"key":"10.1016\/j.addr.2021.05.026_b0115","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/gutjnl-2017-315691","article-title":"Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation","volume":"67","author":"Ibrahim","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0120","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1194\/jlr.M063412","article-title":"Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner","volume":"57","author":"Kakazu","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.addr.2021.05.026_b0125","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/hep4.1556","article-title":"Characterization and proteome of circulating extracellular vesicles as potential biomarkers for NASH","volume":"4","author":"Povero","year":"2020","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0130","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/hep.23148","article-title":"Immature myeloid cells induced by a high-fat diet contribute to liver inflammation","volume":"50","author":"Deng","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0135","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/hep.28252","article-title":"Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes","volume":"63","author":"Ibrahim","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0140","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jhep.2019.07.019","article-title":"Integrin beta1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH","volume":"71","author":"Guo","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0145","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1002\/jcb.25973","article-title":"Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity","volume":"118","author":"Tomita","year":"2017","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.addr.2021.05.026_b0150","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/hep4.1069","article-title":"TRAIL deletion prevents liver, but not adipose tissue, inflammation during murine diet-induced obesity","volume":"1","author":"Hirsova","year":"2017","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0155","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.3389\/fimmu.2018.02980","article-title":"Hepatocyte-derived lipotoxic extracellular vesicle sphingosine 1-phosphate induces macrophage chemotaxis","volume":"9","author":"Liao","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2021.05.026_b0160","doi-asserted-by":"crossref","first-page":"165753","DOI":"10.1016\/j.bbadis.2020.165753","article-title":"Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles","volume":"1866","author":"Hernandez","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.addr.2021.05.026_b0165","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI83885","article-title":"Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9","volume":"126","author":"Garcia-Martinez","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2021.05.026_b0170","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.31031","article-title":"Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets","volume":"72","author":"Hwang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0175","doi-asserted-by":"crossref","first-page":"e113651","DOI":"10.1371\/journal.pone.0113651","article-title":"Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease","volume":"9","author":"Povero","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.05.026_b0180","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3390\/jcm9072032","article-title":"Role of extracellular vesicles in the pathophysiology, diagnosis and tracking of non-alcoholic fatty liver disease","volume":"9","author":"Newman","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0185","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.addr.2021.05.026_b0190","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/hep.31050","article-title":"Lipotoxic Hepatocyte-Derived Exosomal MicroRNA 192\u20135p Activates Macrophages Through Rictor\/Akt\/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease","volume":"72","author":"Liu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0195","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1","volume":"72","author":"Jiang","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0200","doi-asserted-by":"crossref","first-page":"e141513","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2021.05.026_b0205","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1038\/srep15878","article-title":"Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle","volume":"5","author":"Choi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.05.026_b0210","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/oby.20847","article-title":"Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells","volume":"22","author":"Kranendonk","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.addr.2021.05.026_b0215","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jss.2014.06.050","article-title":"Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease","volume":"192","author":"Koeck","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.addr.2021.05.026_b0220","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.7150\/thno.42167","article-title":"Current understanding of the role of Adipose-derived Extracellular Vesicles in Metabolic Homeostasis and Diseases: Communication from the distance between cells\/tissues","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2021.05.026_b0225","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41467-020-14450-6","article-title":"Liver governs adipose remodelling via extracellular vesicles in response to lipid overload","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0230","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1002\/hep.30369","article-title":"Alcohol-related liver disease: areas of consensus, unmet needs and opportunities for further study","volume":"69","author":"Szabo","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12967-015-0623-9","article-title":"Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis","volume":"13","author":"Momen-Heravi","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0240","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hep.31256","article-title":"Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis","volume":"73","author":"Sehrawat","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0245","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.29080","article-title":"A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis","volume":"66","author":"Bissonnette","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0250","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/apt.14564","article-title":"Microvesicles in hepatic and peripheral vein can predict nonresponse to corticosteroid therapy in severe alcoholic hepatitis","volume":"47","author":"Sukriti","year":"2018","journal-title":"Aliment Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.05.026_b0255","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00109-020-01926-7","article-title":"Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1beta and IL-17 upregulation in alcoholic hepatitis mice","volume":"98","author":"Eguchi","year":"2020","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.addr.2021.05.026_b0260","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1074\/jbc.M115.694133","article-title":"MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages","volume":"291","author":"Saha","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.05.026_b0265","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1038\/srep09991","article-title":"Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS","volume":"5","author":"Momen-Heravi","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.addr.2021.05.026_b0270","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1002\/hep.30766","article-title":"Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease","volume":"70","author":"Babuta","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0275","doi-asserted-by":"crossref","first-page":"e92634","DOI":"10.1172\/jci.insight.92634","article-title":"Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity","volume":"2","author":"Cai","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.addr.2021.05.026_b0280","doi-asserted-by":"crossref","first-page":"e136496","DOI":"10.1172\/jci.insight.136496","article-title":"Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1\/p38MAPKalpha-dependent mechanisms","volume":"5","author":"Ma","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.addr.2021.05.026_b0285","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbrc.2017.07.145","article-title":"Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications","volume":"491","author":"Kumar","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0290","doi-asserted-by":"crossref","first-page":"603771","DOI":"10.3389\/fphar.2020.603771","article-title":"Intestinal epithelial cell-derived extracellular vesicles modulate hepatic injury via the gut-liver axis during acute alcohol injury","volume":"11","author":"Lamas-Paz","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.addr.2021.05.026_b0295","doi-asserted-by":"crossref","first-page":"587628","DOI":"10.3389\/fcimb.2020.587628","article-title":"Pathogenesis of viral hepatitis-induced chronic liver disease: role of extracellular vesicles","volume":"10","author":"Lim","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.addr.2021.05.026_b0300","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.chom.2012.08.010","article-title":"Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity","volume":"12","author":"Dreux","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2021.05.026_b0305","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fimmu.2016.00335","article-title":"Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection","volume":"7","author":"Kouwaki","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2021.05.026_b0310","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/cmi.2016.24","article-title":"Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction","volume":"14","author":"Yang","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.addr.2021.05.026_b0315","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1189\/jlb.5A1214-582R","article-title":"HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production","volume":"99","author":"Harwood","year":"2016","journal-title":"J. Leukoc Biol."},{"key":"10.1016\/j.addr.2021.05.026_b0320","doi-asserted-by":"crossref","first-page":"e9504","DOI":"10.1371\/journal.pone.0009504","article-title":"A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection","volume":"5","author":"Mengshol","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.05.026_b0325","doi-asserted-by":"crossref","first-page":"e0205886","DOI":"10.1371\/journal.pone.0205886","article-title":"The immunological function of extracellular vesicles in hepatitis B virus-infected hepatocytes","volume":"13","author":"Kakizaki","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.05.026_b0330","doi-asserted-by":"crossref","first-page":"12449","DOI":"10.1074\/jbc.RA120.014317","article-title":"Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model","volume":"295","author":"Kakizaki","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.05.026_b0335","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jhep.2019.03.006","article-title":"Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes","volume":"71","author":"Deng","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0340","doi-asserted-by":"crossref","first-page":"1716513","DOI":"10.1080\/20013078.2020.1716513","article-title":"Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles","volume":"9","author":"Jiang","year":"2020","journal-title":"J. Extracell Vesicles"},{"key":"10.1016\/j.addr.2021.05.026_b0345","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41564-020-0740-y","article-title":"Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection","volume":"5","author":"Costafreda","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.addr.2021.05.026_b0350","doi-asserted-by":"crossref","first-page":"e12833","DOI":"10.1111\/cpr.12833","article-title":"Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade >\/= A2 promoted the progression of liver cancer by transferring miR-25-3p to inhibit the co-expression of TCF21 and HHIP","volume":"53","author":"Ouyang","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.addr.2021.05.026_b0355","first-page":"e02225","article-title":"Exosome-Mediated Intercellular Communication between Hepatitis C Virus-Infected Hepatocytes and Hepatic Stellate Cells","volume":"91","author":"Devhare","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.addr.2021.05.026_b0360","doi-asserted-by":"crossref","first-page":"G990","DOI":"10.1152\/ajpgi.00093.2010","article-title":"Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia","volume":"299","author":"Masyuk","year":"2010","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"10.1016\/j.addr.2021.05.026_b0365","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1002\/hep.30542","article-title":"Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA","volume":"69","author":"McDaniel","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0370","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.29838","article-title":"Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans","volume":"68","author":"Li","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0375","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/hep.30698","article-title":"Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia","volume":"70","author":"Xiao","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0380","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.30662","article-title":"Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0385","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/cells9010190","article-title":"Cholangiocyte-derived exosomal lncRNA H19 promotes macrophage activation and hepatic inflammation under cholestatic conditions","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0390","doi-asserted-by":"crossref","first-page":"C788","DOI":"10.1152\/ajpcell.00250.2019","article-title":"Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11","volume":"317","author":"Katsumi","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.addr.2021.05.026_b0395","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-030-11093-2_9","article-title":"Pericytes in the liver","volume":"1122","author":"Kostallari","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.addr.2021.05.026_b0400","first-page":"646","article-title":"Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gamma, Cell Mol","volume":"1","author":"Povero","year":"2015","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0405","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1038\/s41598-017-03389-2","article-title":"Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.05.026_b0410","doi-asserted-by":"crossref","first-page":"30684","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration","volume":"290","author":"Wang","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.05.026_b0415","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/hep.29803","article-title":"Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2","volume":"68","author":"Kostallari","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0420","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"Gao","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0425","doi-asserted-by":"crossref","first-page":"G491","DOI":"10.1152\/ajpgi.00140.2015","article-title":"Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: role of exosomes in horizontal transfer of Twist1","volume":"309","author":"Chen","year":"2015","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"10.1016\/j.addr.2021.05.026_b0430","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1158\/1541-7786.MCR-17-0298","article-title":"A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer","volume":"15","author":"Yochum","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.addr.2021.05.026_b0435","first-page":"hep.31617","article-title":"Endothelial p300 promotes portal hypertension and hepatic fibrosis through CCL2-mediated angiocrine signaling","author":"Gao","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0440","doi-asserted-by":"crossref","first-page":"G246","DOI":"10.1152\/ajpgi.00118.2016","article-title":"Angiocrine signaling in the hepatic sinusoids in health and disease","volume":"311","author":"Kostallari","year":"2016","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"10.1016\/j.addr.2021.05.026_b0445","doi-asserted-by":"crossref","first-page":"ra88","DOI":"10.1126\/scisignal.2004512","article-title":"Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells","volume":"6","author":"Povero","year":"2013","journal-title":"Sci. Signal"},{"key":"10.1016\/j.addr.2021.05.026_b0450","doi-asserted-by":"crossref","first-page":"21906","DOI":"10.1038\/srep21906","article-title":"Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes","volume":"6","author":"van Diepen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.05.026_b0455","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/j.gastro.2008.09.066","article-title":"Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells","volume":"136","author":"Witek","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0460","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/hep.27318","article-title":"Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles","volume":"61","author":"Lemoinne","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0465","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/cells7080085","article-title":"Coagulation, Microenvironment and Liver Fibrosis","volume":"7","author":"Bitto","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0470","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jhep.2015.08.017","article-title":"Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury","volume":"64","author":"Rautou","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0475","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/hep.27033","article-title":"Circulating microparticle tissue factor activity is increased in patients with cirrhosis","volume":"60","author":"Rautou","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0480","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2012.03.040","article-title":"Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis","volume":"143","author":"Rautou","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.05.026_b0485","doi-asserted-by":"crossref","first-page":"e00333","DOI":"10.14309\/ctg.0000000000000333","article-title":"M.S.G. and the, Small Annexin V-Positive Platelet-Derived Microvesicles Affect Prognosis in Cirrhosis: A Longitudinal Study","volume":"12","author":"Weil","year":"2021","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.addr.2021.05.026_b0490","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2010.03.021","article-title":"Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension","volume":"53","author":"Bosch","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0495","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jhep.2012.03.007","article-title":"Functional aspects on the pathophysiology of portal hypertension in cirrhosis","volume":"57","author":"Garcia-Pagan","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0500","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41575-018-0097-3","article-title":"Hepatic microcirculation and mechanisms of portal hypertension","volume":"16","author":"Gracia-Sancho","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0505","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1172\/JCI124566","article-title":"Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm","volume":"130","author":"Poisson","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2021.05.026_b0510","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gutjnl-2015-309600","article-title":"Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis","volume":"66","author":"Klein","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0515","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jhep.2019.12.010","article-title":"Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension","volume":"72","author":"Garcia-Tsao","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0520","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/hep.30199","article-title":"Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension","volume":"69","author":"Garcia-Tsao","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0525","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep4.1360","article-title":"Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism","volume":"3","author":"Gracia-Sancho","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0530","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0535","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12275-020-0026-3","article-title":"Bacterial bug-out bags: outer membrane vesicles and their proteins and functions","volume":"58","author":"Dineshkumar","year":"2020","journal-title":"J. Microbiol."},{"key":"10.1016\/j.addr.2021.05.026_b0540","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri3837","article-title":"Immune modulation by bacterial outer membrane vesicles","volume":"15","author":"Kaparakis-Liaskos","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2021.05.026_b0545","first-page":"163","article-title":"Comparative study of effect of Akkermansia muciniphila and its extracellular vesicles on toll-like receptors and tight junction","volume":"12","author":"Ashrafian","year":"2019","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"10.1016\/j.addr.2021.05.026_b0550","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1038\/emm.2017.282","article-title":"Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0555","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","article-title":"Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease","volume":"67","author":"Grander","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0560","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1136\/gut.2009.181834","article-title":"MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome","volume":"59","author":"Zhou","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0565","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gutjnl-2018-317726","article-title":"Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction","volume":"69","author":"Tulkens","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0570","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0575","doi-asserted-by":"crossref","unstructured":"V. Arroyo, P. Angeli, R. Moreau, R. Jalan, J. Claria, J. Trebicka, J. Fernandez, T. Gustot, P. Caraceni, M. Bernardi, G.C. investigators from the Easl-Clif Consortium, F. European Foundation for the Study of Chronic Liver, The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis, J Hepatol, 74 (2021) 670-685.","DOI":"10.1016\/j.jhep.2020.11.048"},{"key":"10.1016\/j.addr.2021.05.026_b0580","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fimmu.2019.00069","article-title":"Compartmentalization of immune response and microbial translocation in decompensated cirrhosis","volume":"10","author":"Alvarez-Silva","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2021.05.026_b0585","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1038\/ncomms14188","article-title":"Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites","volume":"8","author":"Braig","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0590","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/gut.2008.155028","article-title":"Vascular endothelial growth factor and angiopoietin-2 play a major role in the pathogenesis of vascular leakage in cirrhotic rats","volume":"58","author":"Melgar-Lesmes","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0595","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/hep.29903","article-title":"Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis","volume":"68","author":"Payance","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0600","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5114\/ceh.2015.55567","article-title":"Elevated circulating endothelial cell-derived microparticle levels in patients with liver cirrhosis: a preliminary report","volume":"1","author":"Zuwala-Jagiello","year":"2015","journal-title":"Clin. Exp. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0605","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12967-017-1288-3","article-title":"Absolute quantification of microparticles by flow cytometry in ascites of patients with decompensated cirrhosis: a cohort study","volume":"15","author":"Engelmann","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0610","doi-asserted-by":"crossref","first-page":"36691","DOI":"10.1074\/jbc.M113.512806","article-title":"Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling","volume":"288","author":"Bretz","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.05.026_b0615","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0973-6883(11)60126-6","article-title":"Pathogenesis, diagnosis, and treatment of hepatic encephalopathy","volume":"1","author":"Atluri","year":"2011","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0620","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/cells9030572","article-title":"Extracellular vesicles from hyperammonemic rats induce neuroinflammation and motor incoordination in control rats","volume":"9","author":"Izquierdo-Altarejos","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0625","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"Balusu","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0630","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrgastro.2012.123","article-title":"Hepatopulmonary syndrome: update on pathogenesis and clinical features","volume":"9","author":"Zhang","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0635","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1002\/hep.30079","article-title":"Potential clinical targets in hepatopulmonary syndrome: lessons from experimental models","volume":"68","author":"Raevens","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0640","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41419-019-2087-y","article-title":"Hepatocyte-derived exosomal MiR-194 activates PMVECs and promotes angiogenesis in hepatopulmonary syndrome","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.addr.2021.05.026_b0645","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jhep.2020.02.021","article-title":"Portopulmonary hypertension in the current era of pulmonary hypertension management","volume":"73","author":"Savale","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0650","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chest.2018.09.017","article-title":"Evidence for an association between intrahepatic vascular changes and the development of hepatopulmonary syndrome","volume":"155","author":"Lejealle","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.addr.2021.05.026_b0655","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/cvr\/cvt184","article-title":"Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice","volume":"100","author":"Aliotta","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.addr.2021.05.026_b0660","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1947601913499020","article-title":"Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: a Mechanism of Intercellular Signaling in Human Hepatocellular Cancer","volume":"4","author":"Kogure","year":"2013","journal-title":"Genes Cancer"},{"key":"10.1016\/j.addr.2021.05.026_b0665","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12943-015-0426-x","article-title":"CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA","volume":"14","author":"Conigliaro","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.addr.2021.05.026_b0670","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.dld.2021.01.003","article-title":"Tumor cells derived-extracellular vesicles transfer miR-3129 to promote hepatocellular carcinoma metastasis by targeting TXNIP","volume":"53","author":"Yang","year":"2021","journal-title":"Dig Liver Dis."},{"key":"10.1016\/j.addr.2021.05.026_b0675","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41467-017-02583-0","article-title":"Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer","volume":"9","author":"Fang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0680","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/s41467-020-14869-x","article-title":"Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation","volume":"11","author":"Ji","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0685","doi-asserted-by":"crossref","first-page":"e184","DOI":"10.1038\/emm.2015.68","article-title":"Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma","volume":"47","author":"Sohn","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0690","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1136\/gutjnl-2019-320282","article-title":"Liquid biopsy in the clinical management of hepatocellular carcinoma","volume":"69","author":"von Felden","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.05.026_b0695","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.30607","article-title":"Endoplasmic Reticulum Stress Causes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate Programmed Death Ligand 1 Expression in Macrophages","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0700","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13045-018-0625-1","article-title":"Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties","volume":"11","author":"Wang","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.addr.2021.05.026_b0705","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s13046-018-0965-2","article-title":"Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts","volume":"37","author":"Zhou","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.addr.2021.05.026_b0710","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13105-019-00692-6","article-title":"Adipose-derived exosomes deliver miR-23a\/b to regulate tumor growth in hepatocellular cancer by targeting the VHL\/HIF axis","volume":"75","author":"Liu","year":"2019","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.addr.2021.05.026_b0715","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1038\/s41388-018-0619-z","article-title":"Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7","volume":"38","author":"Zhang","year":"2019","journal-title":"Oncogene"},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2021.05.026_b0720","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/hep.31410","article-title":"The tumor microenvironment in cholangiocarcinoma progression","volume":"73","author":"Fabris","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0725","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/hep.31493","article-title":"A novel circular RNA, circ-CCAC1, contributes to CCA progression, induces angiogenesis, and disrupts vascular endothelial barriers","volume":"73","author":"Xu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0730","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.28735","article-title":"Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model","volume":"65","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0735","doi-asserted-by":"crossref","first-page":"16400","DOI":"10.18632\/oncotarget.24711","article-title":"Extracellular vesicle-encapsulated miR-30e suppresses cholangiocarcinoma cell invasion and migration via inhibiting epithelial-mesenchymal transition","volume":"9","author":"Ota","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.addr.2021.05.026_b0740","doi-asserted-by":"crossref","first-page":"16070","DOI":"10.1038\/s41598-018-34309-7","article-title":"Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice","volume":"8","author":"Cho","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.addr.2021.05.026_b0745","doi-asserted-by":"crossref","unstructured":"M. Schmelzle, K. Splith, L.W. Andersen, M. Kornek, D. Schuppan, C. Jones-Bamman, M. Nowak, V. Toxavidis, S.D. Salhanick, L. Han, J. Schulte am Esch, S. Jonas, M.W. Donnino, S.C. Robson, Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury, Transplantation, 95 (2013) 63-69.","DOI":"10.1097\/TP.0b013e318278d3cd"},{"key":"10.1016\/j.addr.2021.05.026_b0750","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13287-020-01738-z","article-title":"Plasma membrane vesicles of human umbilical cord mesenchymal stem cells ameliorate acetaminophen-induced damage in HepG2 cells: a novel stem cell therapy","volume":"11","author":"Lin","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2021.05.026_b0755","doi-asserted-by":"crossref","first-page":"31869","DOI":"10.1038\/srep31869","article-title":"Isolation and characterization of vesicular and non-vesicular microRNAs circulating in sera of partially hepatectomized rats","volume":"6","author":"Castoldi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.05.026_b0760","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/stem.2548","article-title":"Transplantation of Thy1(+) Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling","volume":"35","author":"Ichinohe","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0765","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3390\/cells9051243","article-title":"Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation","volume":"9","author":"Meyer","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0770","doi-asserted-by":"crossref","unstructured":"S. Kuhn, K. Splith, C. Ballschuh, L. Feldbrugge, F. Krenzien, G. Atanasov, C. Benzing, H.M. Hau, C. Engelmann, T. Berg, J. Schulte Am Esch, J. Pratschke, S.C. Robson, M. Schmelzle, Mononuclear-cell-derived microparticles attenuate endothelial inflammation by transfer of miR-142-3p in a CD39 dependent manner, Purinergic Signal, 14 (2018) 423-432.","DOI":"10.1007\/s11302-018-9624-5"},{"key":"10.1016\/j.addr.2021.05.026_b0775","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2015.07.030","article-title":"Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate","volume":"64","author":"Nojima","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0780","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jhep.2009.10.005","article-title":"ATP release after partial hepatectomy regulates liver regeneration in the rat","volume":"52","author":"Gonzales","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.05.026_b0785","doi-asserted-by":"crossref","first-page":"118821","DOI":"10.1016\/j.lfs.2020.118821","article-title":"hUCB-MSC derived exosomal miR-124 promotes rat liver regeneration after partial hepatectomy via downregulating Foxg1","volume":"265","author":"Song","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2021.05.026_b0790","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.29605","article-title":"Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia\/reperfusion injury","volume":"67","author":"Yang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.addr.2021.05.026_b0795","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1089\/scd.2019.0085","article-title":"Human mesenchymal stromal cell-derived extracellular vesicles improve liver regeneration after ischemia reperfusion injury in mice","volume":"28","author":"Anger","year":"2019","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.addr.2021.05.026_b0800","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12015-020-10078-7","article-title":"Protective effects of human liver stem cell-derived extracellular vesicles in a mouse model of hepatic ischemia-reperfusion injury","volume":"17","author":"Calleri","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.addr.2021.05.026_b0805","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1074\/jbc.M114.605253","article-title":"The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes","volume":"290","author":"Guo","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.05.026_b0810","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s12079-017-0421-7","article-title":"Pathways of production and delivery of hepatocyte exosomes","volume":"12","author":"Chen","year":"2018","journal-title":"J. Cell Commun Signal"},{"key":"10.1016\/j.addr.2021.05.026_b0815","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2337\/db20-0146","article-title":"A High-Fat Diet Attenuates AMPK alpha1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo","volume":"70","author":"Yan","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2021.05.026_b0820","doi-asserted-by":"crossref","first-page":"e92821","DOI":"10.1172\/jci.insight.92821","article-title":"Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms","volume":"2","author":"Drinane","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.addr.2021.05.026_b0825","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/lt.25874","article-title":"Extracellular vesicles as a novel therapeutic option in liver transplantation","volume":"26","author":"Carlson","year":"2020","journal-title":"Liver Transpl."},{"key":"10.1016\/j.addr.2021.05.026_b0830","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jcyt.2018.12.006","article-title":"Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing","volume":"21","author":"Rohde","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.addr.2021.05.026_b0835","first-page":"e125652","article-title":"Human induced pluripotent stem cell-derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis, JCI","volume":"5","author":"Povero","year":"2019","journal-title":"Insight"},{"key":"10.1016\/j.addr.2021.05.026_b0840","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1159\/000480533","article-title":"Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia\/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway","volume":"43","author":"Du","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.addr.2021.05.026_b0845","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/scrt465","article-title":"Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models","volume":"5","author":"Tan","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2021.05.026_b0850","doi-asserted-by":"crossref","first-page":"3212643","DOI":"10.1155\/2018\/3212643","article-title":"Extracellular vesicles from amnion-derived mesenchymal stem cells ameliorate hepatic inflammation and fibrosis in rats","volume":"2018","author":"Ohara","year":"2018","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.addr.2021.05.026_b0855","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/j.1582-4934.2009.00860.x","article-title":"Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats","volume":"14","author":"Herrera","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.addr.2021.05.026_b0860","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ymthe.2019.10.016","article-title":"HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis","volume":"28","author":"Bruno","year":"2020","journal-title":"Mol Ther"},{"key":"10.1016\/j.addr.2021.05.026_b0865","doi-asserted-by":"crossref","first-page":"1461505","DOI":"10.1080\/20013078.2018.1461505","article-title":"Therapeutic effects of serum extracellular vesicles in liver fibrosis","volume":"7","author":"Chen","year":"2018","journal-title":"J. Extracell Vesicles"},{"key":"10.1016\/j.addr.2021.05.026_b0870","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4939-7652-2_15","article-title":"Milk-derived extracellular vesicles for therapeutic delivery of small interfering RNAs","volume":"1740","author":"Matsuda","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.addr.2021.05.026_b0875","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/hep4.1462","article-title":"Targeting liver cancer stem cells using engineered biological nanoparticles for the treatment of hepatocellular cancer","volume":"4","author":"Ishiguro","year":"2020","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.addr.2021.05.026_b0880","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.3390\/cells8121560","article-title":"Extracellular vesicles-encapsulated MicroRNA-125b produced in genetically modified mesenchymal stromal cells inhibits hepatocellular carcinoma cell proliferation","volume":"8","author":"Baldari","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.addr.2021.05.026_b0885","doi-asserted-by":"crossref","first-page":"11550","DOI":"10.18632\/aging.103302","article-title":"Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.addr.2021.05.026_b0890","doi-asserted-by":"crossref","unstructured":"O.P.B. Wiklander, M.A. Brennan, J. Lotvall, X.O. Breakefield, S. El Andaloussi, Advances in therapeutic applications of extracellular vesicles, Sci Transl Med, 11 (2019) eaav8521.","DOI":"10.1126\/scitranslmed.aav8521"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21001903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21001903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:24:18Z","timestamp":1777515858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X21001903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":178,"alternative-id":["S0169409X21001903"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2021.05.026","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of extracellular vesicles in liver diseases and their therapeutic potential","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2021.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113816"}}