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Lungile Nomcebo Thwala, Ana Beloqui, Noemi Stefania Csaba, David Gonz\u00e1lez-Touceda, Sulay Tovar, Carlos Dieguez, Maria Jose Alonso, The interaction of protamine nanocapsules with the intestinal epithelium: A mechanistic approach, J. Control. 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Heppner, Jr., Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S\/AS01B and RTS,S\/AS02A in malaria-naive adults: Safety, efficacy, and immunologic associates of protection, J. Infect. Dis. 200 (2009) 337\u2013346. https:\/\/doi.org\/10.1086\/600120.","DOI":"10.1086\/600120"},{"issue":"1","key":"10.1016\/j.addr.2021.113899_b0985","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/14760584.2016.1213632","article-title":"Adjuvant system AS01: helping to overcome the challenges of modern vaccines","volume":"16","author":"Didierlaurent","year":"2017","journal-title":"Expert Rev. Vaccines."},{"key":"10.1016\/j.addr.2021.113899_b0990","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1023\/A:1012128907225","article-title":"Chitosan and Chitosan\/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines","volume":"14","author":"Calvo","year":"1997","journal-title":"Pharm. 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Nanobiotechnology."},{"issue":"4","key":"10.1016\/j.addr.2021.113899_b1200","first-page":"1349","article-title":"Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity, Nanomedicine Nanotechnology","volume":"14","author":"Wang","year":"2018","journal-title":"Biol. Med."},{"key":"10.1016\/j.addr.2021.113899_b1205","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3389\/fimmu.2018.00791","article-title":"Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System","volume":"9","author":"Peleteiro","year":"2018","journal-title":"Front. 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Ther."},{"issue":"10","key":"10.1016\/j.addr.2021.113899_b1230","doi-asserted-by":"crossref","first-page":"e0186079","DOI":"10.1371\/journal.pone.0186079","article-title":"Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One."},{"issue":"8","key":"10.1016\/j.addr.2021.113899_b1235","doi-asserted-by":"crossref","first-page":"e0202997","DOI":"10.1371\/journal.pone.0202997","article-title":"Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques","volume":"13","author":"Li","year":"2018","journal-title":"PLoS One."},{"key":"10.1016\/j.addr.2021.113899_b1240","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.3389\/fimmu.2020.01935","article-title":"Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens","volume":"11","author":"Toledo","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.addr.2021.113899_b1245","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s13346-020-00721-8","article-title":"Technological challenges in the preclinical development of an HIV nanovaccine candidate","volume":"10","author":"Dacoba","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.addr.2021.113899_b1250","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.biomaterials.2015.10.034","article-title":"Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands","volume":"75","author":"Pavot","year":"2016","journal-title":"Biomaterials."},{"key":"10.1016\/j.addr.2021.113899_b1255","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/nano9101389","article-title":"Calcium Phosphate Nanoparticle-Based Vaccines as a Platform for Improvement of HIV-1 Env Antibody Responses by Intrastructural Help","volume":"9","author":"Damm","year":"2019","journal-title":"Nanomaterials."},{"issue":"8","key":"10.1016\/j.addr.2021.113899_b1260","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41565-020-0737-y","article-title":"COVID-19 vaccine development and a potential nanomaterial path forward","volume":"15","author":"Shin","year":"2020","journal-title":"Nat. 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Kamata, Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice, Nat. Biomed. Eng. 3 (2019) 706\u2013716. https:\/\/doi.org\/10.1038\/s41551-019-0434-z.","DOI":"10.1038\/s41551-019-0434-z"},{"key":"10.1016\/j.addr.2021.113899_b1755","doi-asserted-by":"crossref","unstructured":"M. Qin, L. Wang, D. Wu, C.K. Williams, D. Xu, E. Kranz, Q. Guo, J. Guan, H. V Vinters, Y.J. Lee, Y. Xie, Y. Luo, G. Sun, X. Sun, Z. He, Y. Lu, M. Kamata, J. Wen, I.S.Y. Chen, Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates, Front. 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