{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:43:36Z","timestamp":1793256216725,"version":"4.5.0"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.addr.2021.113915","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T04:40:33Z","timestamp":1628397633000},"page":"113915","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["In vivo models to evaluate ingestible devices: Present status and current trends"],"prefix":"10.1016","volume":"177","author":[{"given":"Konstantinos","family":"Stamatopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"O'Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Batchelor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2021.113915_b0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/bdd.2510160502","article-title":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals","volume":"16","author":"Kararli","year":"1995","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2021.113915_b0010","doi-asserted-by":"crossref","first-page":"2632368","DOI":"10.1155\/2016\/2632368","article-title":"Surgical Anatomy of the Gastrointestinal Tract and Its Vasculature in the Laboratory Rat","volume":"2016","author":"Vdoviakov\u00e1","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.addr.2021.113915_b0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4253\/wjge.v7.i1.13","article-title":"Small bowel capsule endoscopy: Where are we after almost 15 years of use?","volume":"7","author":"Van de Bruaene","year":"2015","journal-title":"World J. Gastrointest. Endosc."},{"key":"10.1016\/j.addr.2021.113915_b0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jcmgh.2016.04.003","article-title":"Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals","volume":"2","author":"Camilleri","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.113915_b0025","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1053\/gast.2000.20844","article-title":"A randomized trial comparing wireless capsule endoscopy with push enteroscopy for the detection of small-bowel lesions","volume":"119","author":"Appleyard","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0030","doi-asserted-by":"crossref","first-page":"898","DOI":"10.2460\/ajvr.71.8.898","article-title":"Assessment of the relationship between body weight and gastrointestinal transit times measured by use of a wireless motility capsule system in dogs","volume":"71","author":"Boillat","year":"2010","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.addr.2021.113915_b0035","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2460\/ajvr.71.8.903","article-title":"Variability associated with repeated measurements of gastrointestinal tract motility in dogs obtained by use of a wireless motility capsule system and scintigraphy","volume":"71","author":"Boillat","year":"2010","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.addr.2021.113915_b0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/vaa.12093","article-title":"Effect of prolonged general anesthesia with sevoflurane and laparoscopic surgery on gastric and small bowel propulsive motility and pH in dogs","volume":"41","author":"Boscan","year":"2014","journal-title":"Vet Anaesth Analg"},{"key":"10.1016\/j.addr.2021.113915_b0045","first-page":"763","article-title":"The use of wireless capsule enteroscopy in a preclinical study: a novel diagnostic tool for indomethacin-induced gastrointestinal injury in experimental pigs","volume":"29","author":"Kvetina","year":"2008","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.addr.2021.113915_b0050","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s10544-014-9890-0","article-title":"In Vitro and In Vivo characterization of wireless and passive micro system enabling gastrointestinal pressure monitoring","volume":"16","author":"Shi","year":"2014","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113915_b0055","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.2042-3306.2011.00533.x","article-title":"Evaluation of a wireless ambulatory capsule (SmartPill\u00ae) to measure gastrointestinal tract pH, luminal pressure and temperature, and transit time in ponies","volume":"44","author":"Stokes","year":"2012","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.addr.2021.113915_b0060","series-title":"In vitro models to evaluate ingestible devices: present status and current trends","author":"O'Farrell","year":"2021"},{"key":"10.1016\/j.addr.2021.113915_b0065","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11695-020-05012-2","article-title":"Sleeve Volume and Preoperative Gastric Volume Assessment Using Three-dimensional MDCT Gastrography and Their Correlation to Short-term Post-Sleeve Gastrectomy Weight Loss","volume":"31","author":"El-Sayes","year":"2021","journal-title":"Obes. Surg."},{"key":"10.1016\/j.addr.2021.113915_b0070","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1381\/0960892055002158","article-title":"Size, Volume and Weight of the Stomach in Patients with Morbid Obesity Compared to Controls","volume":"15","author":"Csendes","year":"2005","journal-title":"Obes. Surg."},{"key":"10.1016\/j.addr.2021.113915_b0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11695-019-04189-5","article-title":"Stomach Volume Assessment Using Three-dimensional Computed Tomography Gastrography for Bariatric Treatment","volume":"30","author":"Kim","year":"2020","journal-title":"Obes. Surg."},{"key":"10.1016\/j.addr.2021.113915_b0080","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0031-9384(88)90333-2","article-title":"Gastric distension and gastric capacity in relation to food intake in humans","volume":"44","author":"Geliebter","year":"1988","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.addr.2021.113915_b0085","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/jps.24365","article-title":"Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans","volume":"104","author":"Hatton","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2019.101488","article-title":"In vivo measurement of gastric fluid volume in anesthetized dogs","volume":"55","author":"Wang","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.addr.2021.113915_b0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/bdd.1828","article-title":"Size discrimination in rat and mouse gastric emptying","volume":"34","author":"Jang","year":"2013","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2021.113915_b0100","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1208\/s12248-021-00590-0","article-title":"Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics","volume":"23","author":"Martinez","year":"2021","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2021.113915_b0105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/bdd.2155","article-title":"Quantification of in vivo gastric fluid volume in Bama miniature pigs in fasted state","volume":"39","author":"Guo","year":"2018","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2021.113915_b0110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jddst.2014.12.002","article-title":"A dynamic in vitro model to evaluate the intestinal release behaviour of modified-release corticosteroid products","volume":"25","author":"Goyanes","year":"2015","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.addr.2021.113915_b0115","doi-asserted-by":"crossref","unstructured":"D. Armstrong, Review article: gastric pH -- the most relevant predictor of benefit in reflux disease?, Aliment. Pharmacol. Therap., 20(Suppl 5) (2004) 19\u201326; discussion 38\u2013119.","DOI":"10.1111\/j.1365-2036.2004.02140.x"},{"key":"10.1016\/j.addr.2021.113915_b0120","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1007\/s10620-005-3048-0","article-title":"Regional postprandial differences in pH within the stomach and gastroesophageal junction","volume":"50","author":"Simonian","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0125","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1012107801889","article-title":"Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women","volume":"14","author":"Lindahl","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0130","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/gut.30.5.573","article-title":"Comparison of gastric body and antral pH: a 24 hour ambulatory study in healthy volunteers","volume":"30","author":"McLauchlan","year":"1989","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0135","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/1751-2980.12676","article-title":"Effect of high-fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects","volume":"19","author":"Fan","year":"2018","journal-title":"J. Digest. Dis."},{"key":"10.1016\/j.addr.2021.113915_b0140","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1002\/jps.24274","article-title":"Investigation of pH and temperature profiles in the GI tract of fasted human subjects using the Intellicap\u00ae system","volume":"104","author":"Koziolek","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0145","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1023\/A:1015827908309","article-title":"Upper gastrointestinal (GI) pH in young, healthy men and women","volume":"7","author":"Dressman","year":"1990","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1018970323716","article-title":"Upper gastrointestinal pH in seventy-nine healthy, elderly, North American men and women","volume":"10","author":"Russell","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0155","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.3748\/wjg.v16.i43.5496","article-title":"Gastric juice acidity in upper gastrointestinal diseases","volume":"16","author":"Lu","year":"2010","journal-title":"World J. Gastroenterol.: WJG"},{"key":"10.1016\/j.addr.2021.113915_b0160","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/BF01535781","article-title":"24-hour study of intragastric acidity in duodenal ulcer patients and normal subjects using continuous intraluminal pH-metry","volume":"33","author":"Savarino","year":"1988","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0165","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-2036.1998.00358.x","article-title":"Gastrointestinal pH profiles in patients with inflammatory bowel disease","volume":"12","author":"Press","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113915_b0170","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2036.1989.tb00254.x","article-title":"pH-profile and regional transit times of the normal gut measured by a radiotelemetry device","volume":"3","author":"Fallingborg","year":"1989","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113915_b0175","article-title":"Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn's disease","volume":"92","author":"Sasaki","year":"1997","journal-title":"Am. J. Gastroenterol. (Springer Nature)"},{"key":"10.1016\/j.addr.2021.113915_b0180","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s11095-008-9580-9","article-title":"Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems","volume":"25","author":"Ibekwe","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0185","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/BF03015530","article-title":"Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery","volume":"46","author":"Lydon","year":"1999","journal-title":"Can. J. Anesth."},{"key":"10.1016\/j.addr.2021.113915_b0190","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11095-005-8476-1","article-title":"Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability\/bioequivalence studies","volume":"23","author":"Kalantzi","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0195","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1208\/s12248-016-9952-8","article-title":"A Quantitative Review and Meta-Models of the Variability and Factors Affecting Oral Drug Absorption-Part I: Gastrointestinal pH","volume":"18","author":"Abuhelwa","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2021.113915_b0200","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejps.2010.09.019","article-title":"Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development","volume":"42","author":"Merchant","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105627","article-title":"Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule","volume":"156","author":"Henze","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0215","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1023\/A:1015936426906","article-title":"Gastrointestinal transit of nondisintegrating, nonerodible oral dosage forms in pigs","volume":"7","author":"Hossain","year":"1990","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1098-2299(199606)38:2<73::AID-DDR1>3.0.CO;2-H","article-title":"Evaluation of gastrointestinal pH and gastric residence time via the Heidelberg Radiotelemetry Capsule: Pharmaceutical application","volume":"38","author":"Mojaverian","year":"1996","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.addr.2021.113915_b0225","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/jps.23159","article-title":"Gastric pH and Gastric Residence Time in Fasted and Fed Conscious Beagle Dogs using the Bravo\u00ae pH System","volume":"101","author":"Mahar","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0230","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1002\/jps.21602","article-title":"Fed and fasted gastric pH and gastric residence time in conscious beagle dogs","volume":"98","author":"Sagawa","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0235","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0939-6411(99)00070-3","article-title":"Gastric pH profiles of beagle dogs and their use as an alternative to human testing","volume":"49","author":"Akimoto","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0240","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11095-007-9358-5","article-title":"Gastric pH and gastric residence time in fasted and fed conscious cynomolgus monkeys using the Bravo\u00ae pH system","volume":"25","author":"Chen","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0245","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejpb.2019.01.026","article-title":"Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule","volume":"136","author":"Koziolek","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0250","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1021\/mp500022u","article-title":"Intragastric Volume Changes after Intake of a High-Caloric, High-Fat Standard Breakfast in Healthy Human Subjects Investigated by MRI","volume":"11","author":"Koziolek","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0255","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/gut.18.7.541","article-title":"Gastric emptying of barium sulphate suspension compared with that of water","volume":"18","author":"Ramsbottom","year":"1977","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0260","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/gut.23.6.524","article-title":"Measurement of gastric emptying by real-time ultrasound","volume":"23","author":"Bateman","year":"1982","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0265","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0016-5085(92)90823-H","article-title":"Measurement of gastric emptying by magnetic resonance imaging in humans","volume":"103","author":"Schwizer","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0270","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1021\/mp500210c","article-title":"Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State","volume":"11","author":"Mudie","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0275","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/acs.molpharmaceut.7b00623","article-title":"Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions","volume":"14","author":"Grimm","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0280","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/acs.molpharmaceut.7b00919","article-title":"Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects","volume":"15","author":"Grimm","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0285","doi-asserted-by":"crossref","first-page":"G1227","DOI":"10.1152\/ajpgi.2001.280.6.G1227","article-title":"Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI","volume":"280","author":"Marciani","year":"2001","journal-title":"Am. J. Physiol.-Gastroint. Liver Physiol."},{"key":"10.1016\/j.addr.2021.113915_b0290","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13733","article-title":"Codeine delays gastric emptying through inhibition of gastric motility as assessed with a novel diagnostic intragastric balloon catheter","volume":"32","author":"Goelen","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0295","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1208\/s12248-016-9953-7","article-title":"A Quantitative Review and Meta-models of the Variability and Factors Affecting Oral Drug Absorption-Part II: Gastrointestinal Transit Time","volume":"18","author":"Abuhelwa","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2021.113915_b0300","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0168-3659(94)00118-E","article-title":"The effect of food on the gastrointestinal transit and systemic absorption of naproxen from a novel sustained release formulation","volume":"34","author":"Kenyon","year":"1995","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113915_b0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-5173(93)90127-2","article-title":"Gastrointestinal transit and absorption of theophylline from a multiparticulate controlled release formulation","volume":"97","author":"Yuen","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(94)00200-O","article-title":"Comparative gastrointestinal transit of pellet systems of varying density","volume":"114","author":"Clarke","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0315","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0378-5173(93)90078-T","article-title":"Gastrointestinal transit of pellets of differing size and density","volume":"100","author":"Clarke","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0320","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-5173(96)04604-2","article-title":"Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR\/ZOK) and a non-disintegrating tablet with the emphasis on colon","volume":"140","author":"Abrahamsson","year":"1996","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0325","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0378-5173(93)90276-L","article-title":"Do pellet formulations empty from the stomach with food?","volume":"92","author":"Coupe","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0330","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1023\/A:1015849700421","article-title":"Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects","volume":"8","author":"Coupe","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0335","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0378-5173(84)90191-1","article-title":"The effect of food on the gastrointestinal transit of pellets and an osmotic device","volume":"21","author":"Davis","year":"1984","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0340","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.2042-7158.1985.tb05013.x","article-title":"The use of gamma scintigraphy to follow the gastrointestinal transit of pharmaceutical formulations","volume":"37","author":"Christensen","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0345","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF01300748","article-title":"Gastric emptying of indigestible tablets in relation to composition and time of ingestion of meals studied by metal detector","volume":"36","author":"Ewe","year":"1991","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0350","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11095-008-9749-2","article-title":"Meal-induced acceleration of tablet transit through the human small intestine","volume":"26","author":"Fadda","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(89)90082-3","article-title":"Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects","volume":"52","author":"Khosla","year":"1989","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0360","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5173(00)00399-9","article-title":"Gamma-scintigraphic study of the gastrointestinal transit and in vivo dissolution of a controlled release diclofenac sodium formulation in xanthan gum matrices","volume":"201","author":"Billa","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0365","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jconrel.2005.08.018","article-title":"Impact of the intragastric location of extended release tablets on food interactions","volume":"108","author":"Weitschies","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113915_b0370","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1211\/jpp.59.1.0004","article-title":"The influence of non-disintegrating tablet dimensions and density on their gastric emptying in fasted volunteers","volume":"59","author":"Podczeck","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0375","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s11095-008-9580-9","article-title":"Interplay between intestinal pH, transit time and feed status on the in vivo performance of pH responsive ileo-colonic release systems","volume":"25","author":"Ibekwe","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0380","first-page":"1199","article-title":"Dissolution rate and transit times of technetium-99m DTPA-labeled tablets","volume":"28","author":"Maublant","year":"1987","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.addr.2021.113915_b0385","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0378-5173(86)90102-X","article-title":"Gastrointestinal transit of a controlled release naproxen tablet formulation","volume":"32","author":"Davis","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0390","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1015894626403","article-title":"Mechanism of gastric emptying of a nondisintegrating radiotelemetry capsule in man","volume":"8","author":"Mojaverian","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0395","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2982.2007.01061.x","article-title":"Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy","volume":"20","author":"Cassilly","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0400","first-page":"333","article-title":"Gastrointestinal pH profile in subjects with irritable bowel syndrome","volume":"25","author":"Lalezari","year":"2012","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113915_b0405","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/BF01296029","article-title":"Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects","volume":"32","author":"Youngberg","year":"1987","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129076","article-title":"Gastrointestinal pH and transit time profiling in healthy volunteers using the IntelliCap system confirms ileo-colonic release of ColoPulse tablets","volume":"10","author":"Maurer","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113915_b0415","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.2042-7158.1988.tb05220.x","article-title":"Gastric emptying of large single unit dosage forms","volume":"40","author":"Davis","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0420","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejpb.2009.01.004","article-title":"Assessing gastrointestinal motility and disintegration profiles of magnetic tablets by a novel magnetic imaging device and gamma scintigraphy","volume":"74","author":"Goodman","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0425","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-5173(98)00400-1","article-title":"Gastrointestinal transit of pellets in rats: effect of size and density","volume":"180","author":"Tuleu","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0430","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0378-5173(88)90166-4","article-title":"The fate of multiple-unit enteric-coated formulations in the stomach of the dog","volume":"42","author":"Hein\u00e4m\u00e4ki","year":"1988","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0435","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1023\/A:1018939204809","article-title":"Variability in gastric pH and delayed gastric emptying in yucatan miniature pigs","volume":"11","author":"Oberle","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0440","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/BF01296429","article-title":"Variability of migrating motor complex in humans","volume":"37","author":"Dooley","year":"1992","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0445","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrgastro.2012.57","article-title":"The migrating motor complex: control mechanisms and its role in health and disease","volume":"9","author":"Deloose","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.113915_b0450","doi-asserted-by":"crossref","first-page":"8201","DOI":"10.1073\/pnas.1002292107","article-title":"Understanding gastric forces calculated from high-resolution pill tracking","volume":"107","author":"Laulicht","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0455","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-5173(01)00844-4","article-title":"Evaluation of the mechanical destructive force in the stomach of dog","volume":"228","author":"Kamba","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0460","series-title":"Anatomy","author":"Lopez","year":"2021"},{"key":"10.1016\/j.addr.2021.113915_b0465","first-page":"817","article-title":"Anatomy and Physiology of the Small Intestine, Shackelford's Surgery of the Alimentary Tract","author":"Campbell","year":"2019","journal-title":"2 Volume Set"},{"key":"10.1016\/j.addr.2021.113915_b0470","first-page":"200","article-title":"Imaging Approach and Differential Diagnosis","author":"Intestine","year":"2018","journal-title":"Imaging in Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0475","series-title":"Quantitative Human Physiology (Second Edition)","first-page":"796","article-title":"8.3 - Intestinal and Colonic Chemoreception and Motility","author":"Feher","year":"2017"},{"key":"10.1016\/j.addr.2021.113915_b0480","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract - revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113915_b0485","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5455\/javar.2016.c144","article-title":"Topographical and biometrical anatomy of the digestive tract of White New Zealand Rabbit (Oryctolagus cuniculus)","volume":"3","author":"Nath","year":"2016","journal-title":"Journal of Advanced Veterinary and Animal Research"},{"key":"10.1016\/j.addr.2021.113915_b0490","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0306-4522(87)90369-1","article-title":"The number of neurons in the small intestine of mice, guinea-pigs and sheep","volume":"22","author":"Gabella","year":"1987","journal-title":"Neuroscience"},{"key":"10.1016\/j.addr.2021.113915_b0495","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1002\/jps.24274","article-title":"Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap\u00ae System","volume":"104","author":"Koziolek","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0500","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/gut.25.4.386","article-title":"Duodenal pH in health and duodenal ulcer disease: effect of a meal, Coca-Cola, smoking, and cimetidine","volume":"25","author":"McCloy","year":"1984","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0505","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/gut.10.7.569","article-title":"Duodenal pH values in normal controls and in patients with duodenal ulcer","volume":"10","author":"Rune","year":"1969","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0510","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","article-title":"Measurement of gastrointestinal pH profiles in normal ambulant human subjects","volume":"29","author":"Evans","year":"1988","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0515","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1023\/A:1018893409596","article-title":"Small intestinal transit time and intraluminal pH in ileocecal resected patients with Crohn's disease","volume":"43","author":"Fallingborg","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0520","first-page":"681","article-title":"Gastrointestinal pH profiles in ulcerative colitis","volume":"102","author":"Raimundo","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0525","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/gut.15.12.999","article-title":"Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device","volume":"15","author":"Bown","year":"1974","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0530","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2460\/ajvr.1985.46.07.1516","article-title":"Radiotelemetric determination of gastrointestinal pH in four healthy Beagles","volume":"46","author":"Youngberg","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.addr.2021.113915_b0535","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0378-5173(89)90234-2","article-title":"Gastrointestinal transit of non-disintegrating tablets in fed subjects","volume":"53","author":"Khosla","year":"1989","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0540","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1038\/ctg.2015.22","article-title":"Assessment of Tandem Measurements of pH and Total Gut Transit Time in Healthy Volunteers","volume":"6","author":"Mikolajczyk","year":"2015","journal-title":"Clin. Transl. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113915_b0545","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/A:1016353705970","article-title":"Comparison of Canine and Human Gastrointestinal Physiology","volume":"3","author":"Dressman","year":"1986","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0550","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1211\/0022357011775163","article-title":"Gastrointestinal transit of dosage forms in the pig","volume":"53","author":"Davis","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0555","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jconrel.2003.09.015","article-title":"Gastrointestinal transit time of nondisintegrating radio-opaque pellets in suckling and recently weaned piglets","volume":"94","author":"Snoeck","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113915_b0560","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1248\/bpb.26.1442","article-title":"Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology","volume":"26","author":"Ikegami","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2021.113915_b0565","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/bdd.348","article-title":"Gastrointestinal transit of liquids in unfed cynomolgus monkeys","volume":"24","author":"Kondo","year":"2003","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2021.113915_b0570","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S000711459900166X","article-title":"Enhancement of butyrate production in the rat caecocolonic tract by long-term ingestion of resistant potato starch","volume":"82","author":"Le Blay","year":"1999","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.addr.2021.113915_b0575","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.2042-7158.1997.tb06823.x","article-title":"Prediction of the Plasma Concentration Profiles of Orally Administered Drugs in Rats on the Basis of Gastrointestinal Transit Kinetics and Absorbability","volume":"49","author":"Sawamoto","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0580","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-5173(93)90029-F","article-title":"Gastrointestinal transit of a matrix tablet formulation: comparison of canine and human data","volume":"94","author":"Davis","year":"1993","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0585","article-title":"Assessment of the Variation Associated with Repeated Measurement of Gastrointestinal Transit Times and Assessment of the Effect of Oral Ranitidine on Gastrointestinal Transit Times Using a Wireless Motility Capsule System in Dogs","volume":"2012","author":"Lidbury","year":"2012","journal-title":"Veterin. Med. Int."},{"key":"10.1016\/j.addr.2021.113915_b0590","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1094-9194(02)00024-5","article-title":"Rabbit gastrointestinal physiology","volume":"6","author":"Davies","year":"2003","journal-title":"Veterin. Clin. North Am. Exotic Animal Pract."},{"key":"10.1016\/j.addr.2021.113915_b0595","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5599\/admet.4.1.258","article-title":"Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range","volume":"4","author":"Berghausen","year":"2016","journal-title":"ADMET DMPK"},{"key":"10.1016\/j.addr.2021.113915_b0600","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ejpb.2013.01.010","article-title":"Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state","volume":"84","author":"Arndt","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0605","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2020.06.009","article-title":"Development and evaluation of a biorelevant medium simulating porcine gastrointestinal fluids","volume":"154","author":"Henze","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0610","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/jphp.12361","article-title":"Gastrointestinal characterisation and drug solubility determination in animals","volume":"67","author":"Merchant","year":"2015","journal-title":"The Journal of pharmacy and pharmacology"},{"key":"10.1016\/j.addr.2021.113915_b0615","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s11095-006-0207-8","article-title":"Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents","volume":"23","author":"Kalantzi","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0620","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1139\/o65-128","article-title":"Osmolality of Blood and Intestinal Contents in the Pig, Guinea Pig, and Ascaris Lumbricoides","volume":"43","author":"Harpur","year":"1965","journal-title":"Can. J. Biochem."},{"key":"10.1016\/j.addr.2021.113915_b0625","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01062909","article-title":"Intraluminal pressure of the small intestine of the unanesthetized dog","volume":"364","author":"Tasaka","year":"1976","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.addr.2021.113915_b0630","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2982.2004.00605.x","article-title":"A quantitative approach to recording peristaltic activity from segments of rat small intestine in vivo","volume":"17","author":"Bogeski","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0635","first-page":"G738","article-title":"Propagation velocities and frequencies of contractions along canine small intestine","volume":"258","author":"Siegle","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.addr.2021.113915_b0640","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1152\/ajplegacy.1969.217.6.1757","article-title":"A migrating electric complex of canine small intestine","volume":"217","author":"Szurszewski","year":"1969","journal-title":"Am. J. Physiol.-Legacy Content"},{"key":"10.1016\/j.addr.2021.113915_b0645","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0016-5085(75)80138-7","article-title":"Electrical spiking activity and propulsion in small intestine in fed and fasted rats","volume":"68","author":"Ruckebusch","year":"1975","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0650","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0378-5173(02)00043-1","article-title":"Comparison of the mechanical destructive force in the small intestine of dog and human","volume":"237","author":"Kamba","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0655","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/gut.43.2.294","article-title":"Salt and water absorption in the human colon: a modern appraisal","volume":"43","author":"Sandle","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0660","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4253\/wjge.v5.i5.226","article-title":"Colonoscopy in rats: An endoscopic, histological and tomographic study","volume":"5","author":"Bartol\u00ed","year":"2013","journal-title":"World J. Gastrointest. Endosc."},{"key":"10.1016\/j.addr.2021.113915_b0665","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejps.2014.05.004","article-title":"Influence of ageing on the gastrointestinal environment of the rat and its implications for drug delivery","volume":"62","author":"Merchant","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0670","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/(SICI)1097-0185(199803)250:3<292::AID-AR4>3.0.CO;2-2","article-title":"Intestinal dimensions of mice divergently selected for body weight","volume":"250","author":"Ogiolda","year":"1998","journal-title":"Anatom. Rec."},{"key":"10.1016\/j.addr.2021.113915_b0675","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1258\/la.2009.009112","article-title":"Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man","volume":"44","author":"Casteleyn","year":"2010","journal-title":"Lab. Anim."},{"key":"10.1016\/j.addr.2021.113915_b0680","first-page":"483","article-title":"A Geometric Modeling of Dog Intestine","volume":"30","author":"Arslan","year":"2006","journal-title":"Turkish J. Vet. Anim. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0685","doi-asserted-by":"crossref","DOI":"10.1002\/ajp.23035","article-title":"Gross intestinal morphometry and allometry in primates","volume":"81","author":"McGrosky","year":"2019","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.addr.2021.113915_b0690","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1520-6505(1998)7:1<8::AID-EVAN3>3.0.CO;2-C","article-title":"Primate digestion: Interactions among anatomy, physiology, and feeding ecology","volume":"7","author":"Lambert","year":"1998","journal-title":"Evolutionary Anthropology: Issues, News, and Reviews"},{"key":"10.1016\/j.addr.2021.113915_b0695","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1071\/BI9750161","article-title":"Rates of Passage of Digesta and Water Absorption along the Large Intestines of Sheep","volume":"28","author":"Hecker","year":"1975","journal-title":"Cows and Pigs, Australian Journal of Biological Sciences"},{"key":"10.1016\/j.addr.2021.113915_b0700","series-title":"Pediatric Gastrointestinal and Liver Disease (Fourth Edition)","first-page":"324","article-title":"31 - Anatomy and Physiology of the Small and Large Intestines","author":"Shroyer","year":"2011"},{"key":"10.1016\/j.addr.2021.113915_b0705","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3390\/pharmaceutics11040146","article-title":"MRI of the Colon in the Pharmaceutical Field: The Future before us","volume":"11","author":"Sulaiman","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113915_b0710","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.2042-7158.2011.01399.x","article-title":"Mucus thickness in the gastrointestinal tract of laboratory animals","volume":"64","author":"Varum","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113915_b0715","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/pharmaceutics12040296","article-title":"Effect of Food and an Animal's Sex on P-Glycoprotein Expression and Luminal Fluids in the Gastrointestinal Tract of Wistar Rats","volume":"12","author":"Dou","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113915_b0720","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejps.2018.01.043","article-title":"Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery","volume":"115","author":"Afonso-Pereira","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0725","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejps.2014.02.010","article-title":"In vivo methods for drug absorption \u2013 Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation\/API\/excipient characterization including food effects","volume":"57","author":"Sj\u00f6gren","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0730","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jmor.1051660306","article-title":"Morphology of the gastrointestinal tract in primates: Comparisons with other mammals in relation to diet","volume":"166","author":"Chivers","year":"1980","journal-title":"J. Morphol."},{"key":"10.1016\/j.addr.2021.113915_b0735","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/gut.16.11.894","article-title":"Bile acids and colonic motility in the rabbit and the human","volume":"16","author":"Kirwan","year":"1975","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0740","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0021-9258(18)84086-8","article-title":"The pH of the Contents of the Gastrointestinal Tract in Dogs, in relation to Diet and Rickets","volume":"76","author":"Grayzel","year":"1928","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.113915_b0745","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0016-5085(84)80165-1","article-title":"Colonic compensation in transmissible gastroenteritis of swine","volume":"86","author":"Argenzio","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0750","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/expphysiol.1989.sp003299","article-title":"Water absorption from the pig proximal colon: relations with feeding and flow of digesta","volume":"74","author":"Theodorou","year":"1989","journal-title":"Quart. J. Exp. Physiol."},{"key":"10.1016\/j.addr.2021.113915_b0755","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s11095-009-9927-x","article-title":"Characterization of the Contents of Ascending Colon to Which Drugs are Exposed After Oral Administration to Healthy Adults","volume":"26","author":"Diakidou","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0760","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1007\/s11095-015-1710-6","article-title":"Characterization of Contents of Distal Ileum and Cecum to Which Drugs\/Drug Products are Exposed During Bioavailability\/Bioequivalence Studies in Healthy Adults","volume":"32","author":"Reppas","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0765","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1007\/s11095-010-0158-y","article-title":"Characterization of the Ascending Colon Fluids in Ulcerative Colitis","volume":"27","author":"Vertzoni","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113915_b0770","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1021\/mp100198q","article-title":"Drug solubility in luminal fluids from different regions of the small and large intestine of humans","volume":"7","author":"Fadda","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113915_b0775","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jcmgh.2016.09.003","article-title":"Large Animal Models: The Key to Translational Discovery in Digestive Disease Research","volume":"2","author":"Ziegler","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.113915_b0780","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13734","article-title":"Normative values for region-specific colonic and gastrointestinal transit times in 111 healthy volunteers using the 3D-Transit electromagnet tracking system: Influence of age, gender, and body mass index","volume":"32","author":"Nandhra","year":"2020","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0785","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/gut.10.10.842","article-title":"A new method for studying gut transit times using radioopaque markers","volume":"10","author":"Hinton","year":"1969","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0790","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/BF02605761","article-title":"Segmental colonic transit time","volume":"24","author":"Arhan","year":"1981","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.addr.2021.113915_b0795","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0016-5085(87)90837-7","article-title":"Simplified assessment of segmental colonic transit","volume":"92","author":"Metcalf","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0800","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2982.2007.01025.x","article-title":"Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary centre","volume":"20","author":"Sadik","year":"2008","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0805","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/j.1365-2982.2010.01543.x","article-title":"Accuracy in assessment of colonic transit time with particles: how many markers should be used?","volume":"22","author":"Abrahamsson","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0810","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.gtc.2007.07.013","article-title":"Constipation: Evaluation and Treatment of Colonic and Anorectal Motility Disorders","volume":"36","author":"Rao","year":"2007","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.addr.2021.113915_b0815","first-page":"G856","article-title":"Transit of solids through the human colon: regional quantification in the unprepared bowel, American Journal of Physiology-Gastrointestinal and Liver","volume":"258","author":"Proano","year":"1990","journal-title":"Physiology"},{"key":"10.1016\/j.addr.2021.113915_b0820","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0016-5085(92)91092-I","article-title":"Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders","volume":"103","author":"Camilleri","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0825","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1111\/j.1572-0241.2000.03195.x","article-title":"Whole gut transit scintigraphy in the clinical evaluation of patients with upper and lower gastrointestinal symptoms","volume":"95","author":"Bonapace","year":"2000","journal-title":"The Am. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113915_b0830","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s10620-009-1041-8","article-title":"Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome","volume":"55","author":"Deiteren","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0835","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2982.2009.01441.x","article-title":"Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions","volume":"22","author":"Deiteren","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0840","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/gutjnl-2011-301181","article-title":"Regional colon transit in patients with dys-synergic defaecation or slow transit in patients with constipation","volume":"61","author":"Nullens","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113915_b0845","first-page":"509","article-title":"Pharmacodynamic and clinical endpoints for functional colonic disorders: statistical considerations","volume":"58","author":"Zinsmeister","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2021.113915_b0850","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/nmo.12242","article-title":"Prevalence of colonic motor or evacuation disorders in patients presenting with chronic nausea and vomiting evaluated by a single gastroenterologist in a tertiary referral practice","volume":"26","author":"Kolar","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0855","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1056\/NEJM199310073291503","article-title":"Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea","volume":"329","author":"von der Ohe","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2021.113915_b0860","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cgh.2008.02.060","article-title":"Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome","volume":"6","author":"Camilleri","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.addr.2021.113915_b0865","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/apt.13351","article-title":"Review article: biomarkers and personalised therapy in functional lower gastrointestinal disorders","volume":"42","author":"Camilleri","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113915_b0870","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.cgh.2009.01.017","article-title":"Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation","volume":"7","author":"Rao","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.addr.2021.113915_b0875","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2982.2010.01517.x","article-title":"Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation","volume":"22","author":"Camilleri","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0880","doi-asserted-by":"crossref","first-page":"G1107","DOI":"10.1152\/ajpgi.00136.2009","article-title":"Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS","volume":"297","author":"Hasler","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2021.113915_b0885","doi-asserted-by":"crossref","first-page":"12TR01","DOI":"10.1088\/1361-6579\/abcd1e","article-title":"Magnetic tracking of gastrointestinal motility","volume":"41","author":"Brinck","year":"2020","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.addr.2021.113915_b0890","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1365-2982.2004.00587.x","article-title":"Magnetic pill tracking: a novel non-invasive tool for investigation of human digestive motility","volume":"17","author":"Stathopoulos","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0895","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-230X-11-145","article-title":"Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system","volume":"11","author":"Wors\u00f8e","year":"2011","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.addr.2021.113915_b0900","first-page":"237","article-title":"Radiographie estimation of colonie transit time with kolomark\u2122 in normal Dogs","volume":"29","author":"Cho","year":"2012","journal-title":"J. Veterinary Clin."},{"key":"10.1016\/j.addr.2021.113915_b0905","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11547-009-0409-3","article-title":"Colonic total and segmental transit times in healthy Italian adults","volume":"114","author":"Pomerri","year":"2009","journal-title":"Radiol. Med. (Torino)"},{"key":"10.1016\/j.addr.2021.113915_b0910","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5056\/jnm.2012.18.1.64","article-title":"Colon transit time according to physical activity level in adults","volume":"18","author":"Song","year":"2012","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0915","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s00384-005-0787-5","article-title":"Colonic response to food in constipation","volume":"21","author":"Bouchoucha","year":"2006","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.addr.2021.113915_b0920","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13020","article-title":"Clinical application of a gadolinium-based capsule as an MRI contrast agent in slow transit constipation diagnostics","volume":"29","author":"Zhi","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0925","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejpb.2016.09.009","article-title":"Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed state","volume":"108","author":"Schneider","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113915_b0930","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13396","article-title":"Technical report: Inter- and intra-rater reliability of regional gastrointestinal transit times measured using the 3D-Transit electromagnet tracking system","volume":"30","author":"Kalsi","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0935","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00330-006-0414-z","article-title":"Assessment of colonic transit time using MRI: a feasibility study","volume":"17","author":"Buhmann","year":"2007","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.addr.2021.113915_b0940","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13451","article-title":"Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system","volume":"31","author":"Mark","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0945","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1440-1746.2004.03492.x","article-title":"Normal colon transit time in healthy Chinese adults in Hong Kong","volume":"19","author":"Chan","year":"2004","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.113915_b0950","first-page":"141","article-title":"Simplified measurement of colonic transit time by one radiography of the abdomen and a single type of marker. Normal values in 82 volunteers related to the sexes","volume":"18","author":"Danquechin Dorval","year":"1994","journal-title":"Gastroenterol. Clin. Biol."},{"key":"10.1016\/j.addr.2021.113915_b0955","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10151-006-0295-9","article-title":"Different segmental transit times in patients with irritable bowelsyndrome and \u201cnormal\u201d colonic transit time: is there a correlation withsymptoms?","volume":"10","author":"Bouchoucha","year":"2006","journal-title":"Tech. Coloproctol."},{"key":"10.1016\/j.addr.2021.113915_b0960","doi-asserted-by":"crossref","DOI":"10.1007\/BF02050328","article-title":"What is the meaning of colorectal transit time measurement?","volume":"35","author":"Bouchoucha","year":"1992","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.addr.2021.113915_b0965","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2460\/ajvr.67.2.342","article-title":"Evaluation of association between body size and large intestinal transit time in healthy dogs","volume":"67","author":"Hernot","year":"2006","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.addr.2021.113915_b0970","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/nmo.12461","article-title":"Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules","volume":"26","author":"Haase","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0975","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/nmo.12713","article-title":"Regional gastrointestinal transit times in severe ulcerative colitis","volume":"28","author":"Haase","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113915_b0980","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1051\/rnd:19890402","article-title":"Flow and passage rate studies at the ileal level in the rabbit","volume":"29","author":"Gidenne","year":"1989","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.addr.2021.113915_b0985","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1113\/jphysiol.1983.sp014661","article-title":"Colonic motility and transit of digesta during hard and soft faeces formation in rabbits","volume":"338","author":"Ehrlein","year":"1983","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.addr.2021.113915_b0990","first-page":"G85","article-title":"Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis, American Journal of Physiology-Gastrointestinal and Liver","volume":"312","author":"Robinson","year":"2017","journal-title":"Physiology"},{"key":"10.1016\/j.addr.2021.113915_b0995","doi-asserted-by":"crossref","first-page":"10140","DOI":"10.3748\/wjg.v22.i46.10140","article-title":"Correlation between colonic secretion and colonic motility in rats: Role of ghrelin","volume":"22","author":"Huang","year":"2016","journal-title":"World J. Gastroenterol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21003082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21003082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:00:55Z","timestamp":1759208455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X21003082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":199,"alternative-id":["S0169409X21003082"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2021.113915","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo models to evaluate ingestible devices: Present status and current trends","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2021.113915","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113915"}}