{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:46:15Z","timestamp":1792205175492,"version":"4.4.0"},"reference-count":406,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.addr.2021.113924","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T23:28:18Z","timestamp":1628724498000},"page":"113924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["In vitro models to evaluate ingestible devices: Present status and current trends"],"prefix":"10.1016","volume":"178","author":[{"given":"Connor","family":"O'Farrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Batchelor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2021.113924_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejps.2016.12.004","article-title":"Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies","volume":"99","author":"Grignard","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0010","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2174\/1389200216666150812123836","article-title":"Physiologically based in vitro models to predict the oral dissolution and absorption of a solid drug delivery system","volume":"16","author":"Li","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.addr.2021.113924_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2019.00144","article-title":"Advances and current challenges in intestinal in vitro model engineering: a digest","volume":"7","author":"Costa","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.addr.2021.113924_b0020","series-title":"Shackelford's Surgery of the Alimentary Tract, 2 Volume Set (Eighth Edition)","first-page":"817","article-title":"Anatomy and Physiology of the Small Intestine","author":"Campbell","year":"2019"},{"key":"10.1016\/j.addr.2021.113924_b0025","first-page":"1","article-title":"Mechanisms, physiology, and recent research progress of gastric emptying","author":"Liu","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b0030","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.mpsur.2020.08.005","article-title":"Anatomy of the stomach","volume":"38","author":"Mahadevan","year":"2020","journal-title":"Surgery (Oxford)"},{"key":"10.1016\/j.addr.2021.113924_b0035","doi-asserted-by":"crossref","first-page":"105812","DOI":"10.1016\/j.ejps.2021.105812","article-title":"Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review","volume":"162","author":"Vinarov","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0040","series-title":"In vivo models to evaluate ingestible devices: present status and current trends","author":"Stamatopolous","year":"2021"},{"key":"10.1016\/j.addr.2021.113924_b0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coph.2017.07.003","article-title":"Oral delivery of biologics using drug-device combinations","volume":"36","author":"Caffarel-Salvador","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.addr.2020.05.004","article-title":"Orally ingestible medical devices for gut engineering","volume":"165\u2013166","author":"Mandsberg","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/acssensors.7b00045","article-title":"Ingestible sensors","volume":"2","author":"Kalantar-zadeh","year":"2017","journal-title":"ACS Sensors"},{"key":"10.1016\/j.addr.2021.113924_b0060","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1021\/mp1001203","article-title":"Dynamic dissolution: a step closer to predictive dissolution testing?","volume":"7","author":"McAllister","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0065","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1080\/10408398.2017.1421900","article-title":"Can dynamic in vitro digestion systems mimic the physiological reality?","volume":"59","author":"Dupont","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.addr.2019.06.010","article-title":"In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends","volume":"142","author":"Berthelsen","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tifs.2019.12.015","article-title":"Current in vitro digestion systems for understanding food digestion in human upper gastrointestinal tract","volume":"96","author":"Li","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.addr.2021.113924_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2020.109296","article-title":"A comparison of different physical stomach models and an analysis of shear stresses and strains in these system","volume":"135","author":"Zhong","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0085","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnaa097","article-title":"Intestinal fermentation in vitro models to study food-induced gut microbiota shift: an updated review","volume":"367","author":"Nissen","year":"2020","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.addr.2021.113924_b0090","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.gie.2010.01.064","article-title":"Remote magnetic manipulation of a wireless capsule endoscope in the esophagus and stomach of humans","volume":"71","author":"Swain","year":"2010","journal-title":"Gastrointest. Endosc."},{"issue":"4","key":"10.1016\/j.addr.2021.113924_b0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1756283X11401645","article-title":"PillCam COLON capsule endoscopy: recent advances and new insights","volume":"4","author":"Adler","year":"2011","journal-title":"Therapeutic Adv. Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1055\/s-0030-1255521","article-title":"Feasibility of stomach exploration with a guided capsule endoscope","volume":"42","author":"Rey","year":"2010","journal-title":"Endoscopy"},{"key":"10.1016\/j.addr.2021.113924_b0105","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.gie.2007.01.033","article-title":"Endoscopic placement of the small-bowel video capsule by using a capsule endoscope delivery device","volume":"65","author":"Holden","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.addr.2021.113924_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/mi10120868","article-title":"Passive wireless pressure sensing for gastric manometry","volume":"10","author":"Benken","year":"2019","journal-title":"Micromachines"},{"key":"10.1016\/j.addr.2021.113924_b0115","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-011014","article-title":"SmartPill\u00aeas an objective parameter for determination of severity and duration of postoperative ileus: study protocol of a prospective, two-arm, open-label trial (the PIDuSA study)","volume":"6","author":"Vilz","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.addr.2021.113924_b0120","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13107","article-title":"Validation of SmartPill\u00aewireless motility capsule for gastrointestinal transit time: Intra-subject variability, software accuracy and comparison with video capsule endoscopy","volume":"29","author":"Diaz Tartera","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41928-017-0004-x","article-title":"A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gut","volume":"1","author":"Kalantar-Zadeh","year":"2018","journal-title":"Nat. Electron."},{"key":"10.1016\/j.addr.2021.113924_b0130","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s11095-005-5272-x","article-title":"A novel in vitro and numerical analysis of shear-induced drug release from extended-release tablets in the fed stomach","volume":"22","author":"Abrahamsson","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0135","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113924_b0140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0016-5085(76)80010-8","article-title":"Measurement of gastric functions during digestion of ordinary solid meals in man","volume":"70","author":"Malagelada","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0145","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1211\/0022357023367","article-title":"Media to simulate the postprandial stomach I. Matching the physicochemical characteristics of standard breakfasts","volume":"56","author":"Klein","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0150","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.addr.2016.03.009","article-title":"Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers","volume":"101","author":"Koziolek","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0155","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s11095-009-9927-x","article-title":"Characterization of the contents of ascending colon to which drugs are exposed after oral administration to healthy adults","volume":"26","author":"Diakidou","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1211\/0022357022511","article-title":"Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine","volume":"56","author":"Kostewicz","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0165","doi-asserted-by":"crossref","unstructured":"C.H. Gu, D. Rao, R.B. Gandhi, J.o.n. Hilden, K. Raghavan, Using a novel multicompartment dissolution system to predict the effect of gastric pH on the oral absorption of weak bases with poor intrinsic solubility, J. Pharm. Sci., 94 (2005) 199-208.","DOI":"10.1002\/jps.20242"},{"key":"10.1016\/j.addr.2021.113924_b0170","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejps.2015.11.012","article-title":"An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation","volume":"82","author":"Kourentas","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0175","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1023\/A:1026147620304","article-title":"Use of a physiologic bicarbonate buffer system for dissolution characterization of ionizable drugs","volume":"20","author":"McNamara","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2009.08.003","article-title":"Physiological bicarbonate buffers: stabilisation and use as dissolution media for modified release systems","volume":"382","author":"Fadda","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0185","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ijpharm.2014.09.003","article-title":"Predicting the gastrointestinal behaviour of modified-release products: utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers","volume":"475","author":"Merchant","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0190","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1208\/s12249-013-9933-5","article-title":"An automated system for monitoring and regulating the pH of bicarbonate buffers","volume":"14","author":"Garbacz","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2021.113924_b0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejps.2013.09.020","article-title":"A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds","volume":"51","author":"Garbacz","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101986","article-title":"Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of their dissolution characteristics using biorelevant dissolution methods","volume":"60","author":"Zakowiecki","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.addr.2021.113924_b0205","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1021\/acs.nanolett.8b05051","article-title":"Biomimetic micromotor enables active delivery of antigens for oral vaccination","volume":"19","author":"Wei","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2021.113924_b0210","article-title":"Micromotor-enabled active drug delivery for in vivo treatment of stomach infection","volume":"8","author":"de \u00c1vila","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.addr.2021.113924_b0215","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/anie.201611774","article-title":"Micromotors spontaneously neutralize gastric acid for pH-responsive payload release","volume":"56","author":"Li","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.addr.2021.113924_b0220","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/nn507097k","article-title":"Artificial micromotors in the mouse\u2019s stomach: a step toward in vivo use of synthetic motors","volume":"9","author":"Gao","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.113924_b0225","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1021\/nl072275j","article-title":"Catalytic motors for transport of colloidal cargo","volume":"8","author":"Sundararajan","year":"2008","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2021.113924_b0230","doi-asserted-by":"crossref","first-page":"7000","DOI":"10.1002\/anie.201301643","article-title":"Self-propelled polymer-based multilayer nanorockets for transportation and drug release","volume":"52","author":"Wu","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.addr.2021.113924_b0235","doi-asserted-by":"crossref","first-page":"10486","DOI":"10.1039\/C4NR03124E","article-title":"Synthetic micro\/nanomotors in drug delivery","volume":"6","author":"Gao","year":"2014","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2021.113924_b0240","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/ange.201611774","article-title":"Micromotors spontaneously neutralize gastric acid for pH-responsive payload release","volume":"129","author":"Li","year":"2017","journal-title":"Angew. Chem."},{"key":"10.1016\/j.addr.2021.113924_b0245","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/smll.200901254","article-title":"Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small-molecule release through a cell monolayer under flow","volume":"5","author":"Ainslie","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.addr.2021.113924_b0250","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2005.09.019","article-title":"Micromachined devices: The impact of controlled geometry from cell-targeting to bioavailability","volume":"109","author":"Tao","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113924_b0255","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1359-6446(05)03489-6","article-title":"Gastrointestinal patch systems for oral drug delivery","volume":"10","author":"Tao","year":"2005","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.addr.2021.113924_b0260","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-3659(03)00005-1","article-title":"Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery","volume":"88","author":"Tao","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113924_b0265","doi-asserted-by":"crossref","DOI":"10.1039\/b800604k","article-title":"Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics","volume":"8","author":"Ainslie","year":"2008","journal-title":"Lab Chip"},{"key":"10.1016\/j.addr.2021.113924_b0270","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/smll.200600240","article-title":"Fabrication of particulate reservoir-containing, capsulelike, and self-folding polymer microstructures for drug delivery","volume":"3","author":"Guan","year":"2007","journal-title":"Small"},{"key":"10.1016\/j.addr.2021.113924_b0275","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/adhm.201200200","article-title":"Top-down fabrication of polyelectrolyte-thermoplastic hybrid microparticles for unidirectional drug delivery to single cells","volume":"2","author":"Zhang","year":"2013","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.addr.2021.113924_b0280","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/adhm.201300676","article-title":"Planar microdevices for enhanced in vivo retention and oral bioavailability of poorly permeable drugs","volume":"3","author":"Chirra","year":"2014","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.addr.2021.113924_b0285","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/btm2.10053","article-title":"Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading","volume":"2","author":"Fox","year":"2017","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2021.113924_b0290","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1021\/acsnano.6b00809","article-title":"Fabrication of sealed nanostraw microdevices for oral drug delivery","volume":"10","author":"Fox","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.113924_b0295","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0168-3659(02)00074-3","article-title":"Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery","volume":"81","author":"Ahmed","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113924_b0300","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1021\/acsnano.0c05426","article-title":"An ingestible self-polymerizing system for targeted sampling of gut microbiota and biomarkers","volume":"14","author":"Chen","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.113924_b0305","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1126\/science.aas9315","article-title":"An ingestible bacterial-electronic system to monitor gastrointestinal health","volume":"360","author":"Mimee","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.addr.2021.113924_b0310","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ydbio.2018.01.006","article-title":"Patterning the gastrointestinal epithelium to confer regional-specific functions","volume":"435","author":"Thompson","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2021.113924_b0315","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1101\/gad.1674008","article-title":"The intestinal stem cell","volume":"22","author":"Barker","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2021.113924_b0320","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.addr.2017.11.001","article-title":"Mucus models to evaluate the diffusion of drugs and particles","volume":"124","author":"Lock","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0325","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejps.2018.01.043","article-title":"Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery","volume":"115","author":"Afonso-Pereira","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0330","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/pharmaceutics12040296","article-title":"Effect of food and an animal's sex on P-glycoprotein expression and luminal fluids in the gastrointestinal tract of wistar rats","volume":"12","author":"Dou","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.014","article-title":"Let's talk about sex: differences in drug therapy in males and females","author":"Madla","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0340","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.1152\/ajpcell.00281.2013","article-title":"Do you know the sex of your cells?","volume":"306","author":"Shah","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.addr.2021.113924_b0345","article-title":"Organoid-based models to study the role of host-microbiota interactions in IBD","author":"Poletti","year":"2020","journal-title":"J. Crohn's and Colitis"},{"key":"10.1016\/j.addr.2021.113924_b0350","doi-asserted-by":"crossref","DOI":"10.1038\/srep03224","article-title":"Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells","volume":"3","author":"Hisha","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b0355","doi-asserted-by":"crossref","DOI":"10.1038\/srep17185","article-title":"Characterization of stem\/progenitor cell cycle using murine circumvallate papilla taste bud organoid","volume":"5","author":"Aihara","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b0360","doi-asserted-by":"crossref","first-page":"16401","DOI":"10.1073\/pnas.1409064111","article-title":"Single Lgr5- or Lgr6-expressing taste stem\/progenitor cells generate taste bud cells ex vivo","volume":"111","author":"Ren","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0365","doi-asserted-by":"crossref","unstructured":"Lalitha S.Y. Nanduri, M. Baanstra, H. Faber, C. Rocchi, E. Zwart, G. deHaan, R. vanOs, RobertP. Coppes, Purification and exvivo expansion of fully functional salivary gland stem cells, Stem Cell Rep., 3 (2014) 957-964.","DOI":"10.1016\/j.stemcr.2014.09.015"},{"key":"10.1016\/j.addr.2021.113924_b0370","doi-asserted-by":"crossref","unstructured":"AaronD. DeWard, J. Cramer, E. Lagasse, Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population, Cell Rep., 9 (2014) 701-711.","DOI":"10.1016\/j.celrep.2014.09.027"},{"key":"10.1016\/j.addr.2021.113924_b0375","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0380","doi-asserted-by":"crossref","first-page":"G1359","DOI":"10.1152\/ajpgi.00493.2011","article-title":"A nomenclature for intestinal in vitro cultures","volume":"302","author":"Stelzner","year":"2012","journal-title":"Am. J. Physiol.-Gastrointestinal Liver Physiology"},{"key":"10.1016\/j.addr.2021.113924_b0385","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/nm.2695","article-title":"Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell","volume":"18","author":"Yui","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2021.113924_b0390","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.stem.2017.05.020","article-title":"Differentiation of human pluripotent stem cells into colonic organoids via transient activation of BMP signaling","volume":"21","author":"M\u00fanera","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2021.113924_b0395","doi-asserted-by":"crossref","first-page":"E2357","DOI":"10.1073\/pnas.1701219114","article-title":"Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids","volume":"114","author":"Fumagalli","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0400","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jcmgh.2018.09.008","article-title":"An organoid-based preclinical model of human gastric cancer","volume":"7","author":"Steele","year":"2019","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b0405","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nm.3802","article-title":"Modeling colorectal cancer using CRISPR-Cas9\u2013mediated engineering of human intestinal organoids","volume":"21","author":"Matano","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2021.113924_b0410","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1074\/jbc.R114.635995","article-title":"Human enteroids\/colonoids and intestinal organoids functionally recapitulate normal intestinal physiology and pathophysiology","volume":"291","author":"Zachos","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.113924_b0415","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nprot.2017.137","article-title":"A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression","volume":"13","author":"Fumagalli","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.addr.2021.113924_b0420","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12015-017-9739-z","article-title":"Emulating host-microbiome ecosystem of human gastrointestinal tract in vitro","volume":"13","author":"Park","year":"2017","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.addr.2021.113924_b0425","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/btm2.10013","article-title":"Microfluidics-based 3D cell culture models: Utility in novel drug discovery and delivery research","volume":"1","author":"Gupta","year":"2016","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.addr.2021.113924_b0430","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jcmgh.2017.12.010","article-title":"Microfluidic organ-on-a-chip models of human intestine","volume":"5","author":"Bein","year":"2018","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b0435","first-page":"6","article-title":"Intestine-on-a-chip: Next level in vitro research model of the human intestine, Current Opinion","volume":"25","author":"Donkers","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2021.113924_b0440","doi-asserted-by":"crossref","unstructured":"M. Kasendra, R. Luc, J. Yin, D.V. Manatakis, G. Kulkarni, C. Lucchesi, J. Sliz, A. Apostolou, L. Sunuwar, J. Obrigewitch, K.-J. Jang, G.A. Hamilton, M. Donowitz, K. Karalis, Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model, eLife, 9 (2020).","DOI":"10.7554\/eLife.50135"},{"key":"10.1016\/j.addr.2021.113924_b0445","doi-asserted-by":"crossref","DOI":"10.1039\/c3ib40126j","article-title":"Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation","volume":"5","author":"Kim","year":"2013","journal-title":"Integr. Biol."},{"key":"10.1016\/j.addr.2021.113924_b0450","doi-asserted-by":"crossref","DOI":"10.1039\/c2lc40074j","article-title":"Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow","volume":"12","author":"Kim","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.addr.2021.113924_b0455","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-015-9966-5","article-title":"A microfluidic cell culture device (\u03bcFCCD) to culture epithelial cells with physiological and morphological properties that mimic those of the human intestine","volume":"17","author":"Chi","year":"2015","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113924_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225661","article-title":"Development of a gut-on-a-chip model for high throughput disease modeling and drug discovery","volume":"20","author":"Beaurivage","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0465","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-016-0143-2","article-title":"Microfluidic Gut-liver chip for reproducing the first pass metabolism","volume":"19","author":"Choe","year":"2017","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113924_b0470","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2019-0065","article-title":"Autologous induced pluripotent stem cell-derived four-organ-chip","volume":"5","author":"Ramme","year":"2019","journal-title":"Future Sci. OA"},{"key":"10.1016\/j.addr.2021.113924_b0475","doi-asserted-by":"crossref","first-page":"G536","DOI":"10.1152\/ajpgi.00350.2012","article-title":"Antral recirculation in the stomach during gastric mixing","volume":"304","author":"Imai","year":"2012","journal-title":"Am. J. Physiol.-Gastrointestinal Liver Physiology"},{"key":"10.1016\/j.addr.2021.113924_b0480","series-title":"Gastrointestinal Motility in Health and Disease","first-page":"349","article-title":"Direct measurement of pyloric diameter and tone in man and their response to cholecystokinin","author":"Munk","year":"1978"},{"key":"10.1016\/j.addr.2021.113924_b0485","first-page":"331","article-title":"Measurement of the diameter of the pylorus in man: Part I","volume":"124","author":"Salessiotis","year":"1972","journal-title":"Exp. Project Clin. Appl., Am. J. Surg."},{"key":"10.1016\/j.addr.2021.113924_b0490","first-page":"313","article-title":"Targeting in the gastrointestinal tract: new approaches","volume":"13","author":"Ritschel","year":"1991","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0495","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1383\/anes.2006.7.2.57","article-title":"Gut motility, sphincters and reflex control","volume":"7","author":"Thomas","year":"2006","journal-title":"Anaesthesia & Intensive Care Med."},{"key":"10.1016\/j.addr.2021.113924_b0500","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.suc.2005.05.009","article-title":"Anatomy and physiology of the stomach","volume":"85","author":"Soybel","year":"2005","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.addr.2021.113924_b0505","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000022151","article-title":"The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori","volume":"46","author":"Newton","year":"2000","journal-title":"Gerontology"},{"key":"10.1016\/j.addr.2021.113924_b0510","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/gut.43.4.470","article-title":"Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised","volume":"43","author":"Newton","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b0515","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejps.2019.04.013","article-title":"Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review","volume":"134","author":"Vertzoni","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0520","article-title":"Gastric secretion","volume":"30","author":"Schubert","year":"2014","journal-title":"Curr. Opin. Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0525","doi-asserted-by":"crossref","first-page":"38","DOI":"10.35755\/jmedassocthai.2021.01.10967","article-title":"Volume and pH of gastric contents in patients undergoing gynecologic laparoscopic surgery during emergence from general anesthesia: A prospective observational study","volume":"104","author":"Buayam","year":"2021","journal-title":"J. Med. Assoc. Thai."},{"issue":"12","key":"10.1016\/j.addr.2021.113924_b0530","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1590\/1806-9282.66.12.1725","article-title":"Ultrasonographic evaluation of gastric content and volume: A systematic review","volume":"66","author":"Rocha","year":"2020","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.addr.2021.113924_b0535","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.burns.2018.05.011","article-title":"Measuring gastric residual volumes in critically ill burn patients \u2014 A systematic review","volume":"45","author":"Pham","year":"2019","journal-title":"Burns"},{"key":"10.1016\/j.addr.2021.113924_b0540","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0924-8579(01)00447-2","article-title":"Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics","volume":"18","author":"Matsumoto","year":"2001","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.addr.2021.113924_b0545","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113924_b0550","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/00365520600610451","article-title":"Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study","volume":"41","author":"Steingoetter","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113924_b0555","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2982.2007.00904.x","article-title":"Intersubject and intrasubject variability of gastric volumes in response to isocaloric liquid meals in functional dyspepsia and health","volume":"19","author":"Fruehauf","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b0560","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1021\/mp500210c","article-title":"Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state","volume":"11","author":"Mudie","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0565","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1021\/mp500022u","article-title":"Intragastric volume changes after intake of a high-caloric, high-fat standard breakfast in healthy human subjects investigated by MRI","volume":"11","author":"Koziolek","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0570","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/acs.molpharmaceut.7b00623","article-title":"Gastric water emptying under fed state clinical trial conditions is as fast as under fasted conditions","volume":"14","author":"Grimm","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0575","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1021\/acs.molpharmaceut.7b00919","article-title":"Gastric emptying and small bowel water content after administration of grapefruit juice compared to water and isocaloric solutions of glucose and fructose: a four-way crossover MRI pilot study in healthy subjects","volume":"15","author":"Grimm","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0580","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejpb.2018.03.002","article-title":"Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water","volume":"127","author":"Grimm","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0585","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/pharmaceutics12070670","article-title":"Exploring the effect of esomeprazole on gastric and duodenal fluid volumes and absorption of ritonavir","volume":"12","author":"de Waal","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b0590","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1023\/A:1012107801889","article-title":"Characterization of fluids from the stomach and proximal jejunum in men and women","volume":"14","author":"Lindahl","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0595","doi-asserted-by":"crossref","unstructured":"M. Efentakis, J.B. Dressman, Gastric juice as a dissolution medium: Surface tension and pH, Eur. J. Drug Metab. Pharmacokinetics, 23 (1998) 97-102.","DOI":"10.1007\/BF03189322"},{"key":"10.1016\/j.addr.2021.113924_b0600","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11095-005-8476-1","article-title":"Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability\/bioequivalence studies","volume":"23","author":"Kalantzi","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0605","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ejpb.2013.05.007","article-title":"Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities","volume":"85","author":"Pedersen","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0610","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/acs.molpharmaceut.7b00426","article-title":"Low buffer capacity and alternating motility along the human gastrointestinal tract: implications for in vivo dissolution and absorption of ionizable drugs","volume":"14","author":"Hens","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0615","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s11095-016-1882-8","article-title":"Characteristics of the human upper gastrointestinal contents in the fasted state under hypo- and A-chlorhydric gastric conditions under conditions of typical drug - drug interaction studies","volume":"33","author":"Litou","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0620","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1023\/A:1007576713216","article-title":"A comparison of the solubility of danazol in human and simulated gastrointestinal fluids","volume":"17","author":"Pedersen","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105535","article-title":"Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions","volume":"155","author":"Pentafragka","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.addr.2021.113924_b0630","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/bdd.670","article-title":"Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates","volume":"30","author":"Diakidou","year":"2009","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2021.113924_b0635","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2019.03.005","article-title":"Variations in gastrointestinal lipases, pH and bile acid levels with food intake, age and diseases: Possible impact on oral lipid-based drug delivery systems","volume":"142","author":"Amara","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.113924_b0640","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejpb.2005.03.002","article-title":"Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds","volume":"60","author":"Vertzoni","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0645","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s11095-006-9209-9","article-title":"Estimation of intragastric solubility of drugs: in what medium?","volume":"24","author":"Vertzoni","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0650","doi-asserted-by":"crossref","DOI":"10.14227\/DT180311P15","article-title":"Simulated biological fluids with possible application in dissolution testing","author":"Marques","year":"2011","journal-title":"Dissolution Technologies"},{"key":"10.1016\/j.addr.2021.113924_b0655","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0378-5173(87)90239-0","article-title":"Dissolution of 4 controlled-release theophylline formulations in milk","volume":"36","author":"Macheras","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0660","first-page":"45","article-title":"Bio relevant media to simulate postprandial conditions in the proximal gut","volume":"4","author":"Janssen","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2021.113924_b0665","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodres.2015.12.006","article-title":"The harmonized INFOGEST in vitro digestion method: From knowledge to action","volume":"88","author":"Egger","year":"2016","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0670","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41596-018-0119-1","article-title":"INFOGEST static in vitro simulation of gastrointestinal food digestion","volume":"14","author":"Brodkorb","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.addr.2021.113924_b0675","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jbiomech.2006.06.006","article-title":"A stomach road or \u201cMagenstrasse\u201d for gastric emptying","volume":"40","author":"Pal","year":"2007","journal-title":"J. Biomech."},{"key":"10.1016\/j.addr.2021.113924_b0680","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1208\/s12248-016-9953-7","article-title":"A quantitative review and meta-models of the variability and factors affecting oral drug absorption-Part II: Gastrointestinal transit time","volume":"18","author":"Abuhelwa","year":"2016","journal-title":"The AAPS J."},{"key":"10.1016\/j.addr.2021.113924_b0685","article-title":"Gastric Emptying, Reference Module in Biomedical Sciences","author":"Jacoby","year":"2017","journal-title":"Elsevier"},{"key":"10.1016\/j.addr.2021.113924_b0690","doi-asserted-by":"crossref","first-page":"38","DOI":"10.14227\/DT260319P38","article-title":"Workshop report: USP workshop on exploring the science of drug absorption","volume":"26","author":"Martinez","year":"2019","journal-title":"Dissolution Technologies"},{"key":"10.1016\/j.addr.2021.113924_b0695","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejpb.2015.03.009","article-title":"In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media","volume":"93","author":"Markopoulos","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0700","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s11095-009-9906-2","article-title":"In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self emulsifying excipients Labrasol and Gelucire 44\/14","volume":"26","author":"Fernandez","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0705","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/08910609409141354","article-title":"Validation of the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) Reactor Using Microorganism-associated Activities","volume":"7","author":"Molly","year":"1994","journal-title":"Microbial Ecology in Health and Disease"},{"key":"10.1016\/j.addr.2021.113924_b0710","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1093\/jn\/130.10.2599","article-title":"Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem is improved by supplementing a soygerm powder","volume":"130","author":"De Boever","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b0715","series-title":"The Impact of Food Bioactives on Health","article-title":"The Simulator of the Human Intestinal Microbial Ecosystem (SHIME\u00ae)","author":"Van de Wiele","year":"2015"},{"key":"10.1016\/j.addr.2021.113924_b0720","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12876-021-01687-8","article-title":"Onset of acid-neutralizing action of a calcium\/magnesium carbonate-based antacid using an artificial stomach model: an in vitro evaluation","volume":"21","author":"Voropaiev","year":"2021","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0725","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1023\/B:PHAM.0000022404.70478.4b","article-title":"A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions","volume":"21","author":"Blanquet","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b0730","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3920\/BM2019.0209","article-title":"Survival of a probiotic-containing product using capsule-within-capsule technology in an in vitro model of the stomach and small intestine","volume":"11","author":"Venema","year":"2020","journal-title":"Beneficial Microbes"},{"key":"10.1016\/j.addr.2021.113924_b0735","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/lam.13211","article-title":"Probiotic survival during a multi-layered tablet development as tested in a dynamic, computer-controlled in vitro model of the stomach and small intestine","volume":"69","author":"Venema","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b0740","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jps.20495","article-title":"Relative bioavailability estimation of carbamazepine crystal forms using an artificial stomach-duodenum model","volume":"95","author":"Carino","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0745","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/mp100116g","article-title":"Use of artificial stomach-duodenum model for investigation of dosing fluid effect on clinical trial variability","volume":"7","author":"Polster","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0750","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejpb.2008.05.029","article-title":"Irregular absorption profiles observed from diclofenac extended release tablets can be predicted using a dissolution test apparatus that mimics in vivo physical stresses","volume":"70","author":"Garbacz","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0755","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/jphp.12332","article-title":"Dissolution of mesalazine modified release tablets under standard and bio-relevant test conditions","volume":"67","author":"Garbacz","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0760","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1039\/c3sm52758a","article-title":"Effect of gel structure on the gastric digestion of whey protein emulsion gels","volume":"10","author":"Guo","year":"2014","journal-title":"Soft Matter"},{"key":"10.1016\/j.addr.2021.113924_b0765","doi-asserted-by":"crossref","first-page":"E627","DOI":"10.1111\/j.1750-3841.2010.01856.x","article-title":"A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach","volume":"75","author":"Kong","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.addr.2021.113924_b0770","unstructured":"A. Selen, W.J. Rodriguez, W.H. Doub, L.F. Buhse, E.G. Chikhale, S.K. De, Z. Gao, A.S. Gehris, L. Hughes, R. Lu, H. Mahayni, P.K. Maturu, T.D. Mehta, AAPS 2011 Poster Presentation: Application of FloVitro\u2122 Technology to Evaluate Dissolution of Furosemide and Danazol in Simulated Media at Fed and Fasted Conditions, https:\/\/pqri.org\/wp-content\/uploads\/2015\/10\/03-PQRI-Dissolution-Buhse-2015.pdf, Accessed March 2021 (2011)."},{"key":"10.1016\/j.addr.2021.113924_b0775","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1039\/c0fo00159g","article-title":"Development of a simple model device for in vitro gastric digestion investigation","volume":"2","author":"Chen","year":"2011","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b0780","series-title":"The Impact of Food Bioactives on Health: in vitro and ex vivo models","first-page":"47","article-title":"Dynamic Gastric Model (DGM)","author":"Thuenemann","year":"2015"},{"key":"10.1016\/j.addr.2021.113924_b0785","doi-asserted-by":"crossref","first-page":"14","DOI":"10.14227\/DT190412P14","article-title":"A formulation case study comparing the dynamic gastric model with conventional dissolution methods","volume":"19","author":"Mann","year":"2012","journal-title":"Dissolution Technologies"},{"key":"10.1016\/j.addr.2021.113924_b0790","article-title":"Assessing drug release and dissolution in the stomach by means of Dynamic Gastric Model: a biorelevant approach","volume":"61","author":"Mercuri","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b0795","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ijpharm.2011.07.046","article-title":"Predicting the human in vivo performance of different oral capsule shell types using a novel in vitro dynamic gastric model","volume":"419","author":"Vardakou","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0800","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.fm.2012.02.013","article-title":"Survival of Lactobacillus rhamnosus strains inoculated in cheese matrix during simulated human digestion","volume":"31","author":"Pitino","year":"2012","journal-title":"J. Food Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b0805","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s13228-012-0018-9","article-title":"Venturing into in vitro physiological upper GI system focusing on the motility effect provided by a mechanised rat stomach model","volume":"4","author":"Chen","year":"2013","journal-title":"Food Digestion"},{"key":"10.1016\/j.addr.2021.113924_b0810","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-5198(19)39988-3","article-title":"Gastric motility changes in capsaicin-induced cytoprotection in the rat stomach","volume":"55","author":"Takeuchi","year":"1991","journal-title":"Japanese J. Pharmacology"},{"key":"10.1016\/j.addr.2021.113924_b0815","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/1750-3841.13683","article-title":"Enhancement of digestibility of casein powder and raw rice particles in an improved dynamic rat stomach model through an additional rolling mechanism","volume":"82","author":"Wu","year":"2017","journal-title":"J. Food Sci."},{"key":"10.1016\/j.addr.2021.113924_b0820","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.foodres.2017.12.082","article-title":"Effects of the gastric juice injection pattern and contraction frequency on the digestibility of casein powder suspensions in an in vitro dynamic rat stomach made with a 3D printed model","volume":"106","author":"Zhang","year":"2018","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0825","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodchem.2013.09.036","article-title":"Validation of a new in vitro dynamic system to simulate infant digestion","volume":"145","author":"M\u00e9nard","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.addr.2021.113924_b0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128276","article-title":"Food-dependent set-up of the DiDGI\u00ae dynamic in vitro system: Correlation with the porcine model for protein digestion of soya-based food","volume":"341","author":"Reynaud","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.addr.2021.113924_b0835","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.lwt.2014.12.014","article-title":"Development of human colonic microbiota in the computer-controlled dynamic SIMulator of the GastroIntestinal tract SIMGI","volume":"61","author":"Barroso","year":"2015","journal-title":"LWT - Food Sci. Technol."},{"key":"10.1016\/j.addr.2021.113924_b0840","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfoodeng.2016.02.025","article-title":"Gastric emptying and morphology of a \u2018near real\u2019 in vitro human stomach model","volume":"183","author":"Chen","year":"2016","journal-title":"J. Food Eng."},{"key":"10.1016\/j.addr.2021.113924_b0845","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/bit.25890","article-title":"Development and validation of a new dynamic computer-controlled model of the human stomach and small intestine","volume":"113","author":"Guerra","year":"2016","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.113924_b0850","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.lwt.2015.08.054","article-title":"Using a dynamic stomach model to study efficacy of supplemental enzymes during simulated digestion","volume":"65","author":"Tran Do","year":"2016","journal-title":"LWT - Food Sci. Technol."},{"key":"10.1016\/j.addr.2021.113924_b0855","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.foodres.2016.10.049","article-title":"Development of an in vitro mechanical gastric system (IMGS) with realistic peristalsis to assess lipid digestibility","volume":"90","author":"Barros","year":"2016","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0860","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.foodres.2016.01.030","article-title":"Development of an advanced in vitro model of the stomach and its evaluation versus human gastric physiology","volume":"88","author":"Bellmann","year":"2016","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0865","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.xphs.2018.03.019","article-title":"Using computational fluid dynamics to compare shear rate and turbulence in the TIM-automated gastric compartment with USP apparatus II","volume":"107","author":"Hopgood","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b0870","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.foodhyd.2016.12.039","article-title":"Dairy food structures influence the rates of nutrient digestion through different in vitro gastric behaviour","volume":"67","author":"Mulet-Cabero","year":"2017","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.addr.2021.113924_b0875","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","article-title":"A standardised static in vitro digestion method suitable for food\u2013an international consensus","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b0880","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189807","article-title":"In vitro dynamic model simulating the digestive tract of 6-month-old infants","volume":"12","author":"Passannanti","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b0885","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bej.2016.10.013","article-title":"Mixing characterization of liquid contents in human gastric digestion simulator equipped with gastric secretion and emptying","volume":"122","author":"Kozu","year":"2017","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.addr.2021.113924_b0890","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2017.07.067","article-title":"A novel mechanical antrum model for the prediction of the gastroretentive potential of dosage forms","volume":"530","author":"Neumann","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0895","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1021\/acs.molpharmaceut.9b00799","article-title":"Application of the GastroDuo as an in vitro dissolution tool to simulate the gastric emptying of the postprandial stomach","volume":"16","author":"Schick","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b0900","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2020.03.013","article-title":"Application of the GastroDuo to study the interplay of drug release and gastric emptying in case of immediate release Aspirin formulations","volume":"151","author":"Schick","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b0905","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11120659","article-title":"Comparison of in vitro and in vivo results using the GastroDuo and the salivary tracer technique: immediate release dosage forms under fasting conditions","volume":"11","author":"Sager","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b0910","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.foodres.2019.04.015","article-title":"Development and validation of a new artificial gastric digestive system","volume":"122","author":"Liu","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108598","article-title":"Development of a Gastric Simulation Model (GSM) incorporating gastric geometry and peristalsis for food digestion study","volume":"125","author":"Li","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.addr.2021.113924_b0920","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1039\/C8FO02586J","article-title":"An advanced near real dynamic: In vitro human stomach system to study gastric digestion and emptying of beef stew and cooked rice","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b0925","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1039\/C8FO02586J","article-title":"An advanced near real dynamic in vitro human stomach system to study gastric digestion and emptying of beef stew and cooked rice","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b0930","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2019.107431","article-title":"New dynamic digestion model reactor that mimics gastrointestinal function","volume":"154","author":"Li","year":"2020","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.addr.2021.113924_b0935","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2019.07.021","article-title":"Characterization of individual particle movement during in vitro gastric digestion in the Human Gastric Simulator (HGS)","volume":"264","author":"Keppler","year":"2020","journal-title":"J. Food Eng."},{"key":"10.1016\/j.addr.2021.113924_b0940","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1515\/ijfe-2020-0159","article-title":"Gastric emptying pattern and disintegration kinetics of cooked rice in a 3D printed in vitro dynamic digestion model ARK\u00ae","volume":"17","author":"Ranganathan","year":"2021","journal-title":"Int. J. Food Eng."},{"key":"10.1016\/j.addr.2021.113924_b0945","first-page":"15","article-title":"The Design","volume":"19","author":"Wickham","year":"2012","journal-title":"Operation, and Application of a Dynamic Gastric Model, Dissolution Technologies"},{"key":"10.1016\/j.addr.2021.113924_b0950","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chom.2015.07.002","article-title":"Chemodetection and destruction of host urea allows helicobacter pylori to locate the epithelium","volume":"18","author":"Huang","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2021.113924_b0955","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/gutjnl-2014-307949","article-title":"A novel human gastric primary cell culture system for modellingHelicobacter pyloriinfection in vitro","volume":"65","author":"Schlaermann","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b0960","article-title":"CD44 plays a functional role in helicobacter pylori-induced epithelial cell proliferation","volume":"11","author":"Blanke","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.addr.2021.113924_b0965","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.stem.2018.09.016","article-title":"A comprehensive human gastric cancer organoid biobank captures tumor subtype heterogeneity and enables therapeutic screening","volume":"23","author":"Yan","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2021.113924_b0970","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b0975","first-page":"23","article-title":"Generation and use of gastric organoids for the study of Helicobacter pylori pathogenesis","author":"Chakrabarti","year":"2020","journal-title":"Human Pluripotent Stem Cell Derived Organoid Models"},{"key":"10.1016\/j.addr.2021.113924_b0980","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/gutjnl-2017-314549","article-title":"Human gastric cancer modelling using organoids","volume":"68","author":"Seidlitz","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b0985","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/gutjnl-2014-307650","article-title":"Helicobacter pyloritargets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells","volume":"64","author":"Wroblewski","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b0990","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"McCracken","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.addr.2021.113924_b0995","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0428-9","article-title":"Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer","volume":"15","author":"Nadauld","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.addr.2021.113924_b1000","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-4939-8600-2_16","article-title":"Mouse-derived gastric organoid and immune cell co-culture for the study of the tumor microenvironment","author":"Chakrabarti","year":"2018","journal-title":"Epithelial Cell Culture"},{"key":"10.1016\/j.addr.2021.113924_b1005","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1113\/jphysiol.2014.283028","article-title":"The use of murine-derived fundic organoids in studies of gastric physiology","volume":"593","author":"Schumacher","year":"2015","journal-title":"J. Physiology"},{"key":"10.1016\/j.addr.2021.113924_b1010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nmeth.2737","article-title":"Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny","volume":"11","author":"Yin","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.addr.2021.113924_b1015","doi-asserted-by":"crossref","unstructured":"T.-a.K. Noguchi, N. Ninomiya, M. Sekine, S. Komazaki, P.-C. Wang, M. Asashima, A. Kurisaki, Generation of stomach tissue from mouse embryonic stem cells, Nat. Cell Biol., 17 (2015) 984-993.","DOI":"10.1038\/ncb3200"},{"key":"10.1016\/j.addr.2021.113924_b1020","doi-asserted-by":"crossref","DOI":"10.1186\/s40164-018-0122-9","article-title":"Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine","volume":"7","author":"Xu","year":"2018","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.addr.2021.113924_b1025","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1039\/C8LC00910D","article-title":"Human stomach-on-a-chip with luminal flow and peristaltic-like motility","volume":"18","author":"Lee","year":"2018","journal-title":"Lab Chip"},{"key":"10.1016\/j.addr.2021.113924_b1030","series-title":"Comprehensive Toxicology (Third Edition)","first-page":"16","article-title":"Physiology of the Gastrointestinal System\u2606","author":"Sauer","year":"2018"},{"key":"10.1016\/j.addr.2021.113924_b1035","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.addr.2021.113924_b1040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract - revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113924_b1045","doi-asserted-by":"crossref","unstructured":"L. Marciani, E.F. Cox, C.L. Hoad, S. Pritchard, J.J. Totman, S. Foley, A. Mistry, S. Evans, P.A. Gowland, R.C. Spiller, Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome, Gastroenterology, 138 (2010) 469-477. e461.","DOI":"10.1053\/j.gastro.2009.10.055"},{"key":"10.1016\/j.addr.2021.113924_b1050","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jps.2600510520","article-title":"Cellulose acetate succinate as an enteric coating for some compressed tablets","volume":"51","author":"Wilken","year":"1962","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1055","unstructured":"V. Gray, J. Dressman, Change of pH requirements for simulated intestinal fluid TS, Pharmacopeial Forum, US PHARMACOPEIAL CONVENTION 12601 TWINBROOK PKWY, ROCKVILLE, MD 20852, 1996, pp. 1943-1945."},{"key":"10.1016\/j.addr.2021.113924_b1060","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1208\/s12248-016-9952-8","article-title":"A quantitative review and meta-models of the variability and factors affecting oral drug absorption-Part I: gastrointestinal pH","volume":"18","author":"Abuhelwa","year":"2016","journal-title":"The AAPS J."},{"key":"10.1016\/j.addr.2021.113924_b1065","doi-asserted-by":"crossref","unstructured":"E. Stippler, S. Kopp, J.B. Dressman, Comparison of US Pharmacopeia Simulated Intestinal Fluid TS (without pancreatin) and Phosphate Standard Buffer pH 6.8, TS of the International Pharmacopoeia with Respect to Their Use in In Vitro Dissolution Testing, Dissolution Technologies, http:\/\/dissolutiontech.com\/DTresour\/200405Articles\/DT200405_A01.pdf (2004).","DOI":"10.14227\/DT110204P6"},{"key":"10.1016\/j.addr.2021.113924_b1070","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1002\/jps.24460","article-title":"<em>In Vivo<\/em> predictive dissolution: comparing the effect of bicarbonate and phosphate buffer on the dissolution of weak acids and weak bases","volume":"104","author":"Krieg","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1075","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2016.03.020","article-title":"Prediction of the precipitation profiles of weak base drugs in the small intestine using a simplified transfer (\u201cdumping\u201d) model coupled with in silico modeling and simulation approach","volume":"103","author":"Kambayashi","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1080","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1023\/A:1011910801212","article-title":"Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs","volume":"15","author":"Galia","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1023\/A:1011984216775","article-title":"Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms","volume":"15","author":"Dressman","year":"1998","journal-title":"Pharm. Res."},{"issue":"7","key":"10.1016\/j.addr.2021.113924_b1090","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s11095-008-9569-4","article-title":"Dissolution media simulating conditions in the proximal human gastrointestinal tract: an update","volume":"25","author":"Jantratid","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejpb.2015.05.015","article-title":"Advances in the design of fasted state simulating intestinal fluids: FaSSIF-V3","volume":"94","author":"Fuchs","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1100","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1208\/s12248-010-9203-3","article-title":"The use of biorelevant dissolution media to forecast the in vivo performance of a drug","volume":"12","author":"Klein","year":"2010","journal-title":"The AAPS J."},{"key":"10.1016\/j.addr.2021.113924_b1105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105138","article-title":"Dissolution behavior of various drugs in different FaSSIF versions","volume":"142","author":"Klumpp","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1110","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1208\/s12248-017-0085-5","article-title":"Evolution of choice of solubility and dissolution media after two decades of biopharmaceutical classification system","volume":"19","author":"Bou-Chacra","year":"2017","journal-title":"The AAPS J."},{"key":"10.1016\/j.addr.2021.113924_b1115","doi-asserted-by":"crossref","unstructured":"A.R. Mackie, N. Rigby, InfoGest Consensus Method, in: Verhoeckx K, Cotter P, L.-E. I (Eds.) The Impact of Food Bioactives on Health: in vitro and ex vivo models, Springer, [Internet]. Cham (CH), 2015.","DOI":"10.1007\/978-3-319-16104-4_2"},{"key":"10.1016\/j.addr.2021.113924_b1120","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1039\/C9FO01293A","article-title":"A standardised semi-dynamic in vitro digestion method suitable for food - an international consensus","volume":"11","author":"Mulet-Cabero","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b1125","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiy096","article-title":"A microbial endocrinology-based simulated small intestinal medium for the evaluation of neurochemical production by gut microbiota","volume":"94","author":"Villageli\u00fa","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.addr.2021.113924_b1130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/03602532.2018.1497647","article-title":"Gut microbiota modulates drug pharmacokinetics","volume":"50","author":"Zhang","year":"2018","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.addr.2021.113924_b1135","first-page":"375","article-title":"The impact of the gut microbiota on drug metabolism and clinical outcome","volume":"89","author":"Enright","year":"2016","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.addr.2021.113924_b1140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/03602532.2020.1718691","article-title":"The metabolic effect of gut microbiota on drugs","volume":"52","author":"Xie","year":"2020","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.addr.2021.113924_b1145","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0016-5085(86)90573-1","article-title":"Human interdigestive motility: Variations in patterns from esophagus to colon","volume":"91","author":"Kellow","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b1150","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2020.00018","article-title":"Manometry of the human ileum and ileocaecal junction in health, disease and surgery: a systematic review","volume":"7","author":"Liu","year":"2020","journal-title":"Frontiers in Surgery"},{"key":"10.1016\/j.addr.2021.113924_b1155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105280","article-title":"Impact of gastrointestinal physiology on drug absorption in special populations\u2013\u2013An UNGAP review","volume":"147","author":"Stillhart","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1160","doi-asserted-by":"crossref","unstructured":"S. Ceuppens, M. Uyttendaele, K. Drieskens, M. Heyndrickx, A. Rajkovic, N. Boon, T.V.d. Wiele, Survival and Germination of Bacillus cereus Spores without Outgrowth or Enterotoxin Production during <i>In Vitro<\/i> Simulation of Gastrointestinal Transit, Applied and Environmental Microbiology, 78 (2012) 7698-7705.","DOI":"10.1128\/AEM.02142-12"},{"key":"10.1016\/j.addr.2021.113924_b1165","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1208\/s12248-012-9333-x","article-title":"An investigation into the utility of a multi-compartmental, dynamic, system of the upper gastrointestinal tract to support formulation development and establish bioequivalence of poorly soluble drugs","volume":"14","author":"Dickinson","year":"2012","journal-title":"The AAPS J."},{"key":"10.1016\/j.addr.2021.113924_b1170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105377","article-title":"The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation","volume":"151","author":"Van Den Abeele","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1175","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s11095-006-9054-x","article-title":"Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats","volume":"23","author":"Dahan","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1180","doi-asserted-by":"crossref","first-page":"E339","DOI":"10.1111\/j.1750-3841.2010.01659.x","article-title":"Mass transfer and nutrient absorption in a simulated model of small intestine","volume":"75","author":"Tharakan","year":"2010","journal-title":"J. Food Sci."},{"key":"10.1016\/j.addr.2021.113924_b1185","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1574-6968.2010.01898.x","article-title":"In vitro evaluation of the prebiotic properties of almond skins","volume":"304","author":"Mandalari","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.addr.2021.113924_b1190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijpharm.2015.11.048","article-title":"Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms","volume":"498","author":"Verwei","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1195","unstructured":"R. Havenaar, Physiologically relevant in vitro methodology to determine true digestibility of carbohydrates and to predict the glycaemic response, http:\/\/www.agfdt.de\/loads\/st06\/havenabb.pdf, 2006."},{"key":"10.1016\/j.addr.2021.113924_b1200","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fny231","article-title":"The Smallest Intestine (TSI)\u2014a low volume in vitro model of the small intestine with increased throughput","volume":"365","author":"Cieplak","year":"2018","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.addr.2021.113924_b1205","doi-asserted-by":"crossref","first-page":"29","DOI":"10.32604\/biocell.2019.04790","article-title":"Design and development of a dual-flow bioreactor mimicking intestinal peristalsis and permeability in epithelial tissue barriers for drug transport assessment","volume":"43","author":"Ram\u00edrez-Fern\u00e1ndez","year":"2019","journal-title":"Biocell"},{"key":"10.1016\/j.addr.2021.113924_b1210","first-page":"319","article-title":"The Computer-Controlled Multicompartmental Dynamic Model of the Gastrointestinal System SIMGI","author":"Barroso","year":"2015","journal-title":"The Impact of Food Bioactives on Health"},{"key":"10.1016\/j.addr.2021.113924_b1215","series-title":"The Impact of Food Bioactives on Health: in vitro and ex vivo models","first-page":"37","article-title":"The TNO Gastro-Intestinal Model (TIM)","author":"Minekus","year":"2015"},{"key":"10.1016\/j.addr.2021.113924_b1220","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.aaf5211","article-title":"Replication of human noroviruses in stem cell-derived human enteroids","volume":"353","author":"Ettayebi","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.addr.2021.113924_b1225","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1128\/JVI.01930-15","article-title":"Human intestinal enteroids: a new model to study human rotavirus infection host restriction, and pathophysiology","volume":"90","author":"Saxena","year":"2016","journal-title":"J. Virology"},{"key":"10.1016\/j.addr.2021.113924_b1230","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-018-0177-8","article-title":"Modelling cryptosporidium infection in human small intestinal and lung organoids","volume":"3","author":"Heo","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1235","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3201\/eid2408.180126","article-title":"Human norovirus replication in human intestinal enteroids as model to evaluate virus inactivation","volume":"24","author":"Costantini","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.addr.2021.113924_b1240","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00250-18","article-title":"Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells","volume":"92","author":"Holly","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.addr.2021.113924_b1245","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/7651_2017_1","article-title":"Human intestinal enteroids: new models to study gastrointestinal virus infections","author":"Zou","year":"2017","journal-title":"Organoids"},{"key":"10.1016\/j.addr.2021.113924_b1250","article-title":"Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape","volume":"15","author":"Boulant","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.addr.2021.113924_b1255","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.antiviral.2015.09.010","article-title":"Modeling rotavirus infection and antiviral therapy using primary intestinal organoids","volume":"123","author":"Yin","year":"2015","journal-title":"Antiviral Res."},{"key":"10.1016\/j.addr.2021.113924_b1260","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12147","article-title":"Salmonella-infected crypt-derived intestinal organoid culture system for host-bacterial interactions","volume":"2","author":"Zhang","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1265","doi-asserted-by":"crossref","DOI":"10.1186\/s13567-017-0478-6","article-title":"Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids","volume":"48","author":"Huang","year":"2017","journal-title":"Vet. Res."},{"key":"10.1016\/j.addr.2021.113924_b1270","doi-asserted-by":"crossref","DOI":"10.1186\/s13567-019-0672-9","article-title":"Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection","volume":"50","author":"Resende","year":"2019","journal-title":"Vet. Res."},{"key":"10.1016\/j.addr.2021.113924_b1275","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4161\/cc.23369","article-title":"Immunosurveillance against tetraploidization-induced colon tumorigenesis","volume":"12","author":"Boil\u00e8ve","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.addr.2021.113924_b1280","doi-asserted-by":"crossref","unstructured":"S.R. Finkbeiner, X.-L. Zeng, B. Utama, R.L. Atmar, N.F. Shroyer, M.K. Estes, T.S. Dermody, Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses, mBio, 3 (2012).","DOI":"10.1128\/mBio.00159-12"},{"key":"10.1016\/j.addr.2021.113924_b1285","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1128\/IAI.00161-15","article-title":"Interaction of salmonella enterica serovar typhimurium with intestinal organoids derived from human induced pluripotent stem cells","volume":"83","author":"Forbester","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.addr.2021.113924_b1290","doi-asserted-by":"crossref","unstructured":"D.R. Hill, S. Huang, M.S. Nagy, V.K. Yadagiri, C. Fields, D. Mukherjee, B. Bons, P.H. Dedhia, A.M. Chin, Y.-H. Tsai, S. Thodla, T.M. Schmidt, S. Walk, V.B. Young, J.R. Spence, Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium, eLife, 6 (2017).","DOI":"10.7554\/eLife.29132"},{"key":"10.1016\/j.addr.2021.113924_b1295","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jcmgh.2018.11.001","article-title":"Human norovirus propagation in human induced pluripotent stem cell-derived intestinal epithelial cells","volume":"7","author":"Sato","year":"2019","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b1300","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1073\/pnas.1617363114","article-title":"Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner","volume":"114","author":"Drummond","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1305","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/s41591-020-0912-6","article-title":"Infection of bat and human intestinal organoids by SARS-CoV-2","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2021.113924_b1310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169412","article-title":"Human gut-on-a-chip supports polarized infection of coxsackie B1 virus in vitro","volume":"12","author":"Villenave","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1315","first-page":"E7","article-title":"Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1320","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-017-0179-y","article-title":"Microfluidic gut-on-a-chip with three-dimensional villi structure","volume":"19","author":"Shim","year":"2017","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113924_b1325","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104815","article-title":"Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models","volume":"65","author":"Kulthong","year":"2020","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.addr.2021.113924_b1330","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1039\/C0LC00273A","article-title":"Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model","volume":"11","author":"Sung","year":"2011","journal-title":"Lab Chip"},{"key":"10.1016\/j.addr.2021.113924_b1335","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/bit.24518","article-title":"In vitro 3D human small intestinal villous model for drug permeability determination","volume":"109","author":"Yu","year":"2012","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.113924_b1340","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s10544-012-9669-0","article-title":"On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic \u2018body-on-a-chip\u2019 devices","volume":"14","author":"Esch","year":"2012","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113924_b1345","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/bit.25180","article-title":"Synthetic small intestinal scaffolds for improved studies of intestinal differentiation","volume":"111","author":"Costello","year":"2014","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.113924_b1350","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1039\/c4ib00157e","article-title":"Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression","volume":"6","author":"Kim","year":"2014","journal-title":"Integr. Biol."},{"key":"10.1016\/j.addr.2021.113924_b1355","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1021\/mp5001422","article-title":"3-D intestinal scaffolds for evaluating the therapeutic potential of probiotics","volume":"11","author":"Costello","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1360","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12984-2","article-title":"Microscale Bioreactors for in situ characterization of GI epithelial cell physiology","volume":"7","author":"Costello","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1365","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-016-0035-5","article-title":"Characterization of tight junction disruption and immune response modulation in a miniaturized Caco-2\/U937 coculture-based in vitro model of the human intestinal barrier","volume":"18","author":"Ramadan","year":"2016","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.addr.2021.113924_b1370","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21201-7","article-title":"Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids","volume":"8","author":"Kasendra","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1375","article-title":"Fluid shear stress enhances differentiation of jejunal human enteroids in intestine-chip","author":"Yin","year":"2020","journal-title":"Am. J. Physiol.-Gastrointestinal Liver Physiol."},{"key":"10.1016\/j.addr.2021.113924_b1380","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.638014","article-title":"Harnessing colon chip technology to identify commensal bacteria that promote host tolerance to infection","volume":"11","author":"Gazzaniga","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1385","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144964","article-title":"Direct on-chip differentiation of intestinal tubules from induced pluripotent stem cells","volume":"21","author":"Naumovska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1390","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-84187-9","article-title":"A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses","volume":"11","author":"de Haan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1395","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700506","article-title":"Organ-on-a-chip platforms: a convergence of advanced materials, cells, and microscale technologies","volume":"7","author":"Ahadian","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.addr.2021.113924_b1400","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113156","article-title":"Gut-on-a-chip: Mimicking and monitoring the human intestine","volume":"181","author":"Marrero","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.addr.2021.113924_b1405","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.trac.2019.04.006","article-title":"Online and in situ analysis of organs-on-a-chip","volume":"115","author":"Santbergen","year":"2019","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.addr.2021.113924_b1410","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41551-019-0397-0","article-title":"A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip","volume":"3","author":"Jalili-Firoozinezhad","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.addr.2021.113924_b1415","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-0304-8","article-title":"Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip","volume":"9","author":"Jalili-Firoozinezhad","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.addr.2021.113924_b1420","doi-asserted-by":"crossref","first-page":"E10539","DOI":"10.1073\/pnas.1810819115","article-title":"Intestinal barrier dysfunction orchestrates the onset of inflammatory host\u2013microbiome cross-talk in a human gut inflammation-on-a-chip","volume":"115","author":"Shin","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1425","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jcmgh.2017.12.008","article-title":"Enhanced utilization of induced pluripotent stem cell-derived human intestinal organoids using microengineered chips","volume":"5","author":"Workman","year":"2018","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b1430","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1021\/acsbiomaterials.7b00023","article-title":"Intestine-on-a-chip microfluidic model for efficient in vitro screening of oral chemotherapeutic uptake","volume":"3","author":"Pocock","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.addr.2021.113924_b1435","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11535","article-title":"A microfluidics-based in vitro model of the gastrointestinal human\u2013microbe interface","volume":"7","author":"Shah","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.113924_b1440","article-title":"Robust bioengineered 3D functional human intestinal epithelium","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1445","doi-asserted-by":"crossref","DOI":"10.1039\/c2lc41215b","article-title":"Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device","volume":"13","author":"Gao","year":"2013","journal-title":"Lab Chip"},{"key":"10.1016\/j.addr.2021.113924_b1450","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2116\/analsci.25.1403","article-title":"A microfluidic system to evaluate intestinal absorption","volume":"25","author":"Imura","year":"2009","journal-title":"Anal. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1455","first-page":"1","article-title":"Anatomy of the caecum, appendix and colon","volume":"38","author":"Mahadevan","year":"2020","journal-title":"Surgery - Oxford International Edition"},{"key":"10.1016\/j.addr.2021.113924_b1460","doi-asserted-by":"crossref","unstructured":"A. Erdogan, Y.Y. Lee, Colon and pelvic floor anatomy and physiology, in: S.S.C. Rao, Y.Y. Lee, U.C. Ghoshal (Eds.) Clinical and Basic Neurogastroenterology and Motility, Academic Press, 2020, pp. 113-126.","DOI":"10.1016\/B978-0-12-813037-7.00008-X"},{"key":"10.1016\/j.addr.2021.113924_b1465","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1021\/acs.molpharmaceut.7b00095","article-title":"Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans","volume":"14","author":"Murray","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1470","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2036.2012.05127.x","article-title":"The effects of loperamide, or loperamide plus simethicone, on the distribution of gut water as assessed by MRI in a mannitol model of secretory diarrhoea","volume":"36","author":"Placidi","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2021.113924_b1475","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/nmo.12243","article-title":"Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI","volume":"26","author":"Pritchard","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1480","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/nmo.12673","article-title":"Quantification and variability in colonic volume with a novel magnetic resonance imaging method","volume":"27","author":"Nilsson","year":"2015","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1485","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1007\/s00261-015-0475-z","article-title":"A novel semi-automatic segmentation method for volumetric assessment of the colon based on magnetic resonance imaging","volume":"40","author":"Sandberg","year":"2015","journal-title":"Abdom. Imaging"},{"key":"10.1016\/j.addr.2021.113924_b1490","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0007114515004183","article-title":"Effect of bread gluten content on gastrointestinal function: a crossover MRI study on healthy humans","volume":"115","author":"Coletta","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b1495","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/nmo.12784","article-title":"Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation","volume":"28","author":"Lam","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1500","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.3945\/ajcn.115.125047","article-title":"Corticotropin-releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomized controlled trial","volume":"103","author":"Murray","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b1505","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/MEG.0000000000000574","article-title":"Opioid-induced bowel dysfunction in healthy volunteers assessed with questionnaires and MRI","volume":"28","author":"Nilsson","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2021.113924_b1510","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12930","article-title":"Colonic content: effect of diet, meals, and defecation","volume":"29","author":"Bendez\u00fa","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1515","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13091","article-title":"Assessment of motion of colonic contents in the human colon using MRI tagging","volume":"29","author":"Pritchard","year":"2017","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1520","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13400","article-title":"Demonstration of differences in colonic volumes, transit, chyme consistency, and response to psyllium between healthy and constipated subjects using magnetic resonance imaging","volume":"30","author":"Major","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1525","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5056\/jnm17058","article-title":"Colorectal transit and volume during treatment with prolonged-release oxycodone\/naloxone versus oxycodone plus macrogol 3350","volume":"24","author":"Poulsen","year":"2018","journal-title":"J. Neurogastroenterology Motility"},{"key":"10.1016\/j.addr.2021.113924_b1530","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00383-009-2387-x","article-title":"Colonic transit studies: normal values for adults and children with comparison of radiological and scintigraphic methods","volume":"25","author":"Southwell","year":"2009","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.addr.2021.113924_b1535","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.46.2.205","article-title":"Effects of fat and carbohydrate meals on colonic motor response","volume":"46","author":"Rao","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b1540","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00151","article-title":"Current sampling methods for gut microbiota: a call for more precise devices","volume":"10","author":"Tang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1545","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s11095-010-0223-6","article-title":"Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility","volume":"27","author":"Vertzoni","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1550","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/gut.22.9.763","article-title":"Short chain fatty acids in the human colon","volume":"22","author":"Cummings","year":"1981","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b1555","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejpb.2011.01.001","article-title":"Evolution of a physiological pH6.8 bicarbonate buffer system: Application to the dissolution testing of enteric coated products","volume":"78","author":"Liu","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1560","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2007.10.026","article-title":"Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora","volume":"125","author":"Yang","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.113924_b1565","doi-asserted-by":"crossref","unstructured":"M. Wahlgren, M. Axenstrand, \u00c5. H\u00e5kansson, A. Marefati, B. Lomstein Pedersen, In Vitro Methods to Study Colon Release: State of the Art and An Outlook on New Strategies for Better In-Vitro Biorelevant Release Media, Pharmaceutics, 11 (2019) 95","DOI":"10.3390\/pharmaceutics11020095"},{"key":"10.1016\/j.addr.2021.113924_b1570","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s11095-010-0223-6","article-title":"Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility","volume":"27","author":"Vertzoni","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160533","article-title":"A single-batch fermentation system to simulate human colonic microbiota for high-throughput evaluation of prebiotics","volume":"11","author":"Takagi","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1580","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.01844","article-title":"The use of a mini-bioreactor fermentation system as a reproducible, high-throughput ex vivo batch model of the distal colon","volume":"9","author":"O\u2019Donnell","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1585","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/jphp.12777","article-title":"Assessing the influence of media composition and ionic strength on drug release from commercial immediate-release and enteric-coated aspirin tablets","volume":"69","author":"Karkossa","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2021.113924_b1590","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijpharm.2016.10.020","article-title":"In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions","volume":"515","author":"Mercuri","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1595","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejps.2015.06.012","article-title":"In vitro solubility, dissolution and permeability studies combined with semi-mechanistic modeling to investigate the intestinal absorption of desvenlafaxine from an immediate- and extended release formulation","volume":"77","author":"Franek","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1600","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejps.2006.09.004","article-title":"A novel dissolution method relevant to intestinal release behaviour and its application in the evaluation of modified release mesalazine products","volume":"30","author":"Schellekens","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1605","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejpb.2018.12.004","article-title":"Individualized in vitro and in silico methods for predicting in vivo performance of enteric-coated tablets containing a narrow therapeutic index drug","volume":"135","author":"Karkossa","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1610","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1021\/acs.molpharmaceut.9b00057","article-title":"Methacrylate-copolymer eudragit EPO as a solubility-enabling excipient for anionic drugs: investigation of drug solubility intestinal permeability, and their interplay","volume":"16","author":"Fine-Shamir","year":"2019","journal-title":"Mol. Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b1615","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1021\/acs.molpharmaceut.6b01129","article-title":"Evaluation of dissolution in the lower intestine and its impact on the absorption process of high dose low solubility drugs","volume":"14","author":"Georgaka","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1620","doi-asserted-by":"crossref","DOI":"10.4103\/japtr.JAPTR_70_17","article-title":"Novel biorelevant dissolution medium as a prognostic tool for polysaccharide-based colon-targeted drug delivery system","volume":"8","author":"Gulati","year":"2017","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.addr.2021.113924_b1625","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejps.2017.03.011","article-title":"Mechanistic investigation of the negative food effect of modified release zolpidem","volume":"102","author":"Andreas","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1630","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejpb.2016.06.010","article-title":"Can dosage form-dependent food effects be predicted using biorelevant dissolution tests? Case example extended release nifedipine","volume":"105","author":"Andreas","year":"2016","journal-title":"Eur. J. Pharmaceutics Biopharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b1635","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejpb.2015.09.002","article-title":"In vitro biorelevant models for evaluating modified release mesalamine products to forecast the effect of formulation and meal intake on drug release","volume":"97","author":"Andreas","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1640","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejps.2015.03.012","article-title":"A novel dissolution method for evaluation of polysaccharide based colon specific delivery systems: A suitable alternative to animal sacrifice","volume":"73","author":"Singh","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.addr.2021.113924_b1645","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejpb.2013.01.002","article-title":"A novel coating concept for ileo-colonic drug targeting: Proof of concept in humans using scintigraphy","volume":"84","author":"Varum","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1650","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1128\/aem.54.11.2750-2755.1988","article-title":"Use of a three-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria","volume":"54","author":"Gibson","year":"1988","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1655","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bpg.2013.03.002","article-title":"Experimental models of the gut microbiome","volume":"27","author":"Venema","year":"2013","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"key":"10.1016\/j.addr.2021.113924_b1660","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s002489900072","article-title":"Validation of a three-stage compound continuous culture system for investigating the effect of retention time on the ecology and metabolism of bacteria in the human colon","volume":"35","author":"Macfarlane","year":"1998","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.addr.2021.113924_b1665","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.femsec.2004.05.002","article-title":"PCR-DGGE-based quantification of stability of the microbial community in a simulator of the human intestinal microbial ecosystem","volume":"49","author":"Possemiers","year":"2004","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.addr.2021.113924_b1670","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2672.1989.tb02524.x","article-title":"Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system","volume":"67","author":"Macfarlane","year":"1989","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.addr.2021.113924_b1675","doi-asserted-by":"crossref","unstructured":"M. Marzorati, B. Vanhoecke, T. De Ryck, M. Sadaghian Sadabad, I. Pinheiro, S. Possemiers, P. Van den Abbeele, L. Derycke, M. Bracke, J. Pieters, T. Hennebel, H.J. Harmsen, W. Verstraete, T. Van de Wiele, The HMI\u2122 module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro, BMC Microbiol., 14 (2014).","DOI":"10.1186\/1471-2180-14-133"},{"key":"10.1016\/j.addr.2021.113924_b1680","doi-asserted-by":"crossref","first-page":"F698","DOI":"10.1152\/ajprenal.2000.279.4.F698","article-title":"A hydrodynamic mechanosensory hypothesis for brush border microvilli","volume":"279","author":"Guo","year":"2000","journal-title":"Am. J. Physiology-Renal Physiology"},{"key":"10.1016\/j.addr.2021.113924_b1685","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2003.12.015","article-title":"Amylose formulations for drug delivery to the colon: a comparison of two fermentation models to assess colonic targeting performance in vitro","volume":"273","author":"Siew","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b1690","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1205\/fbp.04396","article-title":"An engineering model of the human colon","volume":"83","author":"Spratt","year":"2005","journal-title":"Food Bioprod. Process."},{"key":"10.1016\/j.addr.2021.113924_b1695","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1207\/s15327914nc5201_12","article-title":"In vitro effects on polydextrose by colonic bacteria and Caco-2 cell cyclooxygenase gene expression","volume":"52","author":"Makivuokko","year":"2005","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.addr.2021.113924_b1700","doi-asserted-by":"crossref","first-page":"M153","DOI":"10.1111\/j.1750-3841.2007.00350.x","article-title":"The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator","volume":"72","author":"M\u00e4kel\u00e4inen","year":"2007","journal-title":"J. Food Sci."},{"key":"10.1016\/j.addr.2021.113924_b1705","first-page":"203","article-title":"Synbiotic effects of galacto-oligosaccharide, polydextrose and Bifidobacterium lactis Bi-07 in vitro","volume":"5","author":"M\u00e4kel\u00e4inen","year":"2010","journal-title":"Int. J. Probiotics & Prebiotics"},{"key":"10.1016\/j.addr.2021.113924_b1710","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1271\/bbb.60022","article-title":"Effects of lactose on colon microbial community structure and function in a four-stage semi-continuous culture system","volume":"70","author":"M\u00e4kivuokko","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2021.113924_b1715","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1271\/bbb.60706","article-title":"The effect of cocoa and polydextrose on bacterial fermentation in gastrointestinal tract simulations","volume":"71","author":"M\u00e4kivuokko","year":"2014","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.addr.2021.113924_b1720","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49497-z","article-title":"The effect of 2\u2032-fucosyllactose on simulated infant gut microbiome and metabolites; a pilot study in comparison to GOS and lactose","volume":"9","author":"Salli","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1725","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1079\/BJN19950137","article-title":"Estimation of the fermentability of dietary fibrein vitro: a European interlaboratory study","volume":"74","author":"Barry","year":"2007","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b1730","first-page":"281","article-title":"One compartment fermentation model","author":"Aura","year":"2015","journal-title":"The Impact of Food Bioactives on Health"},{"key":"10.1016\/j.addr.2021.113924_b1735","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1021\/jf3008037","article-title":"Formation of phenolic microbial metabolites and short-chain fatty acids from rye, wheat, and oat bran and their fractions in the metabolical in vitro colon model","volume":"60","author":"Nordlund","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.addr.2021.113924_b1740","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00394-012-0391-8","article-title":"Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches","volume":"52","author":"Aura","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b1745","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00394-008-0747-2","article-title":"Factors affecting the conversion of apple polyphenols to phenolic acids and fruit matrix to short-chain fatty acids by human faecal microbiota in vitro","volume":"47","author":"Bazzocco","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.addr.2021.113924_b1750","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/00365528909093060","article-title":"Effect of human faecal donor on in vitro fermentation variables","volume":"24","author":"McBurney","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113924_b1755","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3109\/00365529108998626","article-title":"Fermentation to short-chain fatty acids and lactate in human faecal batch cultures intra- and inter-individual variations versus variations caused by changes in fermented saccharides","volume":"26","author":"Mortensen","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.113924_b1760","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1007\/s11095-011-0620-5","article-title":"Use of artificial digestive systems to investigate the biopharmaceutical factors influencing the survival of probiotic yeast during gastrointestinal transit in humans","volume":"29","author":"Blanquet-Diot","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b1765","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/microorganisms3040725","article-title":"Dynamic in vitro models of the human gastrointestinal tract as relevant tools to assess the survival of probiotic strains and their interactions with gut microbiota","volume":"3","author":"Cordonnier","year":"2015","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2021.113924_b1770","doi-asserted-by":"crossref","first-page":"9097","DOI":"10.1007\/s00253-015-6704-0","article-title":"Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer\u2019s patches","volume":"99","author":"Th\u00e9venot","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.addr.2021.113924_b1775","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1128\/AEM.03303-12","article-title":"Enterohemorrhagic Escherichia coli O157:H7 Survival in anIn VitroModel of the Human Large Intestine and Interactions with Probiotic Yeasts and Resident Microbiota","volume":"79","author":"Th\u00e9venot","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1780","article-title":"Novel Polyfermentor Intestinal Model (PolyFermS) for Controlled Ecological Studies: Validation and Effect of pH","volume":"8","author":"Sanz","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1785","doi-asserted-by":"crossref","unstructured":"R. De Weirdt, T. Van de Wiele, Micromanagement in the gut: microenvironmental factors govern colon mucosal biofilm structure and functionality, npj Biofilms and Microbiomes, 1 (2015).","DOI":"10.1038\/npjbiofilms.2015.26"},{"key":"10.1016\/j.addr.2021.113924_b1790","doi-asserted-by":"crossref","unstructured":"L. Bircher, C. Schwab, A. Geirnaert, A. Greppi, C. Lacroix, P. Wilmes, Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct Composition and Reestablish Differently upon Frozen and Freeze-Dried Long-Term Storage, mSystems, 5 (2020).","DOI":"10.1128\/msystems.00521-19"},{"key":"10.1016\/j.addr.2021.113924_b1795","article-title":"Design and investigation of PolyFermS in vitro continuous fermentation models inoculated with immobilized fecal microbiota mimicking the elderly colon","volume":"10","author":"Weir","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1800","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fix088","article-title":"Effect of dietary nucleosides and yeast extracts on composition and metabolic activity of infant gut microbiota in PolyFermS colonic fermentation models","volume":"93","author":"Doo","year":"2017","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.addr.2021.113924_b1805","article-title":"In vitro continuous fermentation model (PolyFermS) of the swine proximal colon for simultaneous testing on the same gut microbiota","volume":"9","author":"Heimesaat","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1810","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01166","article-title":"Stepwise development of an in vitro continuous fermentation model for the murine caecal microbiota","volume":"10","author":"Poeker","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1815","series-title":"The Impact of Food Bioactives on Health: in vitro and ex vivo models","first-page":"293","article-title":"The TNO in vitro model of the colon (TIM-2)","author":"Venema","year":"2015"},{"key":"10.1016\/j.addr.2021.113924_b1820","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/08910600310018959","article-title":"The effect of various inulins and clostridium difficile on the metabolic activity of the human colonic microbiota in vitro","volume":"15","author":"van Nuenen","year":"2003","journal-title":"Microbial Ecol. Health Dis."},{"key":"10.1016\/j.addr.2021.113924_b1825","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jff.2018.09.028","article-title":"Understanding the impact of chia seed mucilage on human gut microbiota by using the dynamic gastrointestinal model simgi\u00ae","volume":"50","author":"Tamargo","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.addr.2021.113924_b1830","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1751-7915.2011.00308.x","article-title":"Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli","volume":"5","author":"Van den Abbeele","year":"2012","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.addr.2021.113924_b1835","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1039\/C6FO00784H","article-title":"Dietary supplement based on stilbenes: a focus on gut microbial metabolism by the in vitro simulator M-SHIME\u00ae","volume":"7","author":"Giuliani","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2021.113924_b1840","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jff.2017.02.004","article-title":"Long chain arabinoxylans shift the mucosa-associated microbiota in the proximal colon of the simulator of the human intestinal microbial ecosystem","volume":"32","author":"Truchado","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.addr.2021.113924_b1845","article-title":"Establishing a mucosal gut microbial community in vitro using an artificial simulator","volume":"13","author":"Liu","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1850","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160533","article-title":"A single-batch fermentation system to simulate human colonic microbiota for high-throughput evaluation of prebiotics","volume":"11","author":"Takagi","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.addr.2021.113924_b1855","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4268","article-title":"CoMiniGut\u2014a small volumein vitrocolon model for the screening of gut microbial fermentation processes","volume":"6","author":"Wiese","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.addr.2021.113924_b1860","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnaa135","article-title":"A toddler SHIME\u00ae model to study microbiota of young children","volume":"367","author":"Bondue","year":"2020","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.addr.2021.113924_b1865","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12070659","article-title":"Dynamic colon model (DCM): A cine-MRI informed biorelevant in vitro model of the human proximal large intestine characterized by positron imaging techniques","volume":"12","author":"Stamatopoulos","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.113924_b1870","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/nmo.12403","article-title":"Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose","volume":"26","author":"Marciani","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1875","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/jphysiol.1899.sp000752","article-title":"The movements and innervation of the small intestine","volume":"24","author":"Bayliss","year":"1899","journal-title":"J. Physiology"},{"key":"10.1016\/j.addr.2021.113924_b1880","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2016.08.004","article-title":"Dissolution profile of theophylline modified release tablets, using a biorelevant Dynamic Colon Model (DCM)","volume":"108","author":"Stamatopoulos","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1885","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/nmo.12408","article-title":"Quantification ofin vivocolonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry","volume":"26","author":"Dinning","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2021.113924_b1890","article-title":"The use of a mini-bioreactor fermentation system as a reproducible, high-throughput ex vivo batch model of the distal colon","volume":"9","author":"O'Donnell","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2021.113924_b1895","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2016.08.004","article-title":"Dissolution profile of theophylline modified release tablets, using a biorelevant Dynamic Colon Model (DCM)","volume":"108","author":"Stamatopoulos","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.113924_b1900","first-page":"G497","article-title":"HumanClostridium difficileinfection: inhibition of NHE3 and microbiota profile, American Journal of Physiology-Gastrointestinal and Liver","volume":"308","author":"Engevik","year":"2015","journal-title":"Physiology"},{"key":"10.1016\/j.addr.2021.113924_b1905","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.antiviral.2016.07.017","article-title":"Mycophenolic acid potently inhibits rotavirus infection with a high barrier to resistance development","volume":"133","author":"Yin","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.addr.2021.113924_b1910","doi-asserted-by":"crossref","first-page":"E2993","DOI":"10.1073\/pnas.1605997113","article-title":"Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge","volume":"113","author":"Fischer","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.113924_b1915","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/21505594.2017.1326443","article-title":"PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target","volume":"9","author":"Yin","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.addr.2021.113924_b1920","article-title":"Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1925","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcmgh.2015.10.001","article-title":"Enterohemorrhagic escherichia coli reduces mucus and intermicrovillar bridges in human stem cell-derived colonoids","volume":"2","author":"In","year":"2016","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b1930","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2013.11.002","article-title":"Functional repair of CFTR by CRISPR\/Cas9 in intestinal stem cell organoids of cystic fibrosis patients","volume":"13","author":"Schwank","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2021.113924_b1935","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2015.03.053","article-title":"Prospective derivation of a living organoid biobank of colorectal cancer patients","volume":"161","author":"van de Wetering","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.addr.2021.113924_b1940","doi-asserted-by":"crossref","first-page":"C794","DOI":"10.1152\/ajpcell.00420.2020","article-title":"Porcine colonoids and enteroids keep the memory of their origin during regeneration","volume":"320","author":"Barnett","year":"2021","journal-title":"Am. J. Physiology-Cell Physiology"},{"key":"10.1016\/j.addr.2021.113924_b1945","doi-asserted-by":"crossref","unstructured":"J.F. Dekkers, G. Berkers, E. Kruisselbrink, A. Vonk, H.R. de Jonge, H.M. Janssens, I. Bronsveld, E.A. van de Graaf, E.E.S. Nieuwenhuis, R.H.J. Houwen, F.P. Vleggaar, J.C. Escher, Y.B. de Rijke, C.J. Majoor, H.G.M. Heijerman, K.M. de Winter\u2013de Groot, H. Clevers, C.K. van der Ent, J.M. Beekman, Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis, Science Translational Medicine, 8 (2016) 344ra384-344ra384.","DOI":"10.1126\/scitranslmed.aad8278"},{"key":"10.1016\/j.addr.2021.113924_b1950","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis","volume":"63","author":"Johansson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.addr.2021.113924_b1955","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jcmgh.2019.07.009","article-title":"Building a thick mucus hydrogel layer to improve the physiological relevance of in vitro primary colonic epithelial models","volume":"8","author":"Wang","year":"2019","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b1960","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jcmgh.2019.11.008","article-title":"Human colon-on-a-chip enables continuous in vitro analysis of colon mucus layer accumulation and physiology","volume":"9","author":"Sontheimer-Phelps","year":"2020","journal-title":"Cell. Mol. Gastroenterology Hepatology"},{"key":"10.1016\/j.addr.2021.113924_b1965","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78359-2","article-title":"Development of a human primary gut-on-a-chip to model inflammatory processes","volume":"10","author":"Beaurivage","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2021.113924_b1970","doi-asserted-by":"crossref","DOI":"10.3389\/fmedt.2020.00002","article-title":"Robust formation of an epithelial layer of human intestinal organoids in a polydimethylsiloxane-based gut-on-a-chip microdevice","volume":"2","author":"Shin","year":"2020","journal-title":"Frontiers in Medical Technol."},{"key":"10.1016\/j.addr.2021.113924_b1975","doi-asserted-by":"crossref","unstructured":"A. Apostolou, R.A. Panchakshari, A. Banerjee, D.V. Manatakis, M.D. Paraskevopoulou, R. Luc, G. AbuAli, A. Dimitriou, C. Lucchesi, G. Kulkarni, T.I. Maulana, B. Bleck, E.S. Manolakos, G.A. Hamilton, C. Giallourakis, K. Karalis, A Micro-engineered Human Colon Intestine-Chip Platform to Study Leaky Barrier, BioRxiv, Preprint (2020)","DOI":"10.1101\/2020.08.28.271759"},{"key":"10.1016\/j.addr.2021.113924_b1980","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-019-0650-5","article-title":"Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites","volume":"7","author":"Tovaglieri","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.addr.2021.113924_b1985","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.isci.2019.04.037","article-title":"Human intestinal morphogenesis controlled by transepithelial morphogen gradient and flow-dependent physical cues in a microengineered gut-on-a-chip","volume":"15","author":"Shin","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.addr.2021.113924_b1990","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.crfs.2021.04.004","article-title":"A review on the food digestion in the digestive tract and the used in vitro models","volume":"4","author":"Sensoy","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.addr.2021.113924_b1995","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s11095-005-8192-x","article-title":"The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids","volume":"22","author":"Persson","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.113924_b2000","doi-asserted-by":"crossref","unstructured":"M. Perez de la Cruz Moreno, M. Oth, S. Deferme, F. Lammert, J. Tack, J. Dressman, P. Augustijns, Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum, J. Pharmacy Pharmacology, 58 (2006) 1079-1089.","DOI":"10.1211\/jpp.58.8.0009"},{"key":"10.1016\/j.addr.2021.113924_b2005","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jps.20553","article-title":"Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: A case study with amprenavir","volume":"95","author":"Brouwers","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b2010","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jps.21502","article-title":"Postprandial evolution in composition and characteristics of human duodenal fluids in different nutritional states","volume":"98","author":"Clarysse","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b2015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijpharm.2010.12.007","article-title":"Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid","volume":"405","author":"Heikkil\u00e4","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.113924_b2020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejps.2013.01.012","article-title":"Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine","volume":"49","author":"Holmstock","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b2025","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejps.2014.07.009","article-title":"Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability","volume":"63","author":"Stappaerts","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.113924_b2030","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jps.24603","article-title":"Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions","volume":"105","author":"Riethorst","year":"2016","journal-title":"J. Pharm. Sci."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21003173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21003173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:10:03Z","timestamp":1759209003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X21003173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":406,"alternative-id":["S0169409X21003173"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2021.113924","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro models to evaluate ingestible devices: Present status and current trends","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2021.113924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113924"}}