{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:26:31Z","timestamp":1793107591315,"version":"4.5.0"},"reference-count":333,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.addr.2021.114079","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T02:01:09Z","timestamp":1639101669000},"page":"114079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":530,"special_numbering":"C","title":["To PEGylate or not to PEGylate: Immunological properties of nanomedicine\u2019s most popular component, polyethylene glycol and its alternatives"],"prefix":"10.1016","volume":"180","author":[{"given":"Da","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Beasock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Fessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos","family":"Szebeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Y.","family":"Ljubimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill A.","family":"Afonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.","family":"Dobrovolskaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2021.114079_b0005","series-title":"Developing Solid Oral Dosage Forms","first-page":"181","article-title":"Polymer Properties and Characterization","author":"Brady","year":"2017"},{"key":"10.1016\/j.addr.2021.114079_b0010","first-page":"57","article-title":"Polyethylene glycols (PEGs) and the pharmaceutical industry","author":"Henning","year":"2002","journal-title":"Fine Specialty Performance Chem."},{"key":"10.1016\/j.addr.2021.114079_b0015","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0939-6411(98)00038-1","article-title":"Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats","volume":"46","author":"Roser","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.114079_b0025","doi-asserted-by":"crossref","first-page":"8413","DOI":"10.1039\/C8NR00603B","article-title":"Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery","volume":"10","author":"Newland","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2021.114079_b0030","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.1021\/la9041502","article-title":"Conformational studies of covalently grafted poly(ethylene glycol) on modified solid matrices using X-ray photoelectron spectroscopy","volume":"26","author":"Damodaran","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2021.114079_b0035","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bios.2004.01.034","article-title":"XPS and AFM analysis of antifouling PEG interfaces for microfabricated silicon biosensors","volume":"20","author":"Sharma","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.addr.2021.114079_b0040","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1016\/j.biomaterials.2006.03.039","article-title":"Parameters influencing the stealthiness of colloidal drug delivery systems","volume":"27","author":"Vonarbourg","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0045","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1021\/la904355p","article-title":"Encapsulation of a hydrophobic drug into a polymer-micelle core explored with synchrotron SAXS","volume":"26","author":"Akiba","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2021.114079_b0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0005-2736(91)90162-2","article-title":"Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times","volume":"1070","author":"Lasic","year":"1991","journal-title":"BBA"},{"key":"10.1016\/j.addr.2021.114079_b0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0005-2736(92)90112-Y","article-title":"Repulsive interactions and mechanical stability of polymer-grafted lipid membranes","volume":"1108","author":"Needham","year":"1992","journal-title":"BBA"},{"key":"10.1016\/j.addr.2021.114079_b0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0021-9797(91)90043-8","article-title":"Protein-surface interactions in the presence of polyethylene oxide. I. Simpified theory","volume":"142","author":"Jeon","year":"1991","journal-title":"J. Colloid Interf. Scie."},{"key":"10.1016\/j.addr.2021.114079_b0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2005.06.001","article-title":"Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products","volume":"214","author":"Fruijtier-P\u00f6lloth","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2021.114079_b0070","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5487\/TR.2015.31.2.105","article-title":"Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use","volume":"31","author":"Jang","year":"2015","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.addr.2021.114079_b0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejps.2019.01.015","article-title":"Pharmacokinetics, excretion, distribution, and metabolism of 60-kDa polyethylene glycol used in BAY 94\u20139027 in rats and its value for human prediction","volume":"130","author":"Baumann","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13010123","article-title":"Quantitative Cryo-TEM Reveals New Structural Details of Doxil-Like PEGylated Liposomal Doxorubicin Formulation","volume":"13","author":"Nordstr\u00f6m","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.114079_b0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10717540490433895","article-title":"Colloidal gold: a novel nanoparticle vector for tumor directed drug delivery","volume":"11","author":"Paciotti","year":"2004","journal-title":"Drug Deliv"},{"key":"10.1016\/j.addr.2021.114079_b0090","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1089\/ten.2007.0075","article-title":"Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells","volume":"13","author":"Buxton","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.addr.2021.114079_b0095","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0142-9612(98)00025-8","article-title":"Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels","volume":"19","author":"Cruise","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2017.12.007","article-title":"The impact of functional groups of poly(ethylene glycol) macromers on the physical properties of photo-polymerized hydrogels and the local inflammatory response in the host","volume":"67","author":"Day","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2021.114079_b0105","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1073\/pnas.96.6.3104","article-title":"Transdermal photopolymerization for minimally invasive implantation","volume":"96","author":"Elisseeff","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.addr.2021.114079_b0110","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/ja2084338","article-title":"Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake","volume":"134","author":"Walkey","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.addr.2021.114079_b0115","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/mp400703d","article-title":"Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation","volume":"11","author":"Yang","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0120","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1016\/S0021-9258(17)40291-2","article-title":"Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol","volume":"252","author":"Abuchowski","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b0130","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.2147\/IJN.S167443","article-title":"Effects of PEG surface density and chain length on the pharmacokinetics and biodistribution of methotrexate-loaded chitosan nanoparticles","volume":"13","author":"Ait Bachir","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b0135","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1186\/1556-276X-6-563","article-title":"Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution","volume":"6","author":"Hou","year":"2011","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.addr.2021.114079_b0140","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijpharm.2012.04.004","article-title":"Chitosan-g-PEG nanoparticles ionically crosslinked with poly(glutamic acid) and tripolyphosphate as protein delivery systems","volume":"430","author":"Papadimitriou","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0145","doi-asserted-by":"crossref","first-page":"12203","DOI":"10.1021\/acsami.6b16556","article-title":"Impact of PEG Chain Length on the Physical Properties and Bioactivity of PEGylated Chitosan\/siRNA Nanoparticles in Vitro and in Vivo","volume":"9","author":"Yang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2021.114079_b0150","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jss.2013.02.035","article-title":"High molecular weight polyethylene glycol (PEG 15\u201320) maintains mucosal microbial barrier function during intestinal graft preservation","volume":"183","author":"Valuckaite","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.addr.2021.114079_b0155","unstructured":"L.B. Inc., Compositions containing polyethylene glycol and uses thereof, 1999."},{"key":"10.1016\/j.addr.2021.114079_b0160","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00007890-199210000-00044","article-title":"The immunosuppressive effect of polyethylene glycol in a flush solution for rat liver transplantation","volume":"54","author":"Tokunaga","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/j.addr.2021.114079_b0165","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1046\/j.1537-2995.1994.34594249044.x","article-title":"Polyethylene glycol versus low-ionic-strength solution in pretransfusion testing: a blinded comparison study","volume":"34","author":"Shirey","year":"1994","journal-title":"Transfusion"},{"key":"10.1016\/j.addr.2021.114079_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0011-2240(91)90002-6","article-title":"Effect of polyethylene glycol on lipid peroxidation in cold-stored rat hepatocytes","volume":"28","author":"Mack","year":"1991","journal-title":"Cryobiology"},{"key":"10.1016\/j.addr.2021.114079_b0175","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mvr.2008.11.007","article-title":"Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement","volume":"77","author":"Chiang","year":"2009","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.addr.2021.114079_b0180","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2004.02.027","article-title":"Diffusive oxidative stress following acute spinal cord injury in guinea pigs and its inhibition by polyethylene glycol","volume":"359","author":"Luo","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.addr.2021.114079_b0185","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1089\/0897715041651097","article-title":"Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury","volume":"21","author":"Luo","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.addr.2021.114079_b0190","unstructured":"USFDA, Center for Food Safety and Applied Nutrition. Food additive status list. \u201cPolyethylene glycol.\u201d 2019."},{"key":"10.1016\/j.addr.2021.114079_b0195","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/cea.12760","article-title":"Immediate-type hypersensitivity to polyethylene glycols: a review","volume":"46","author":"Wenande","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.addr.2021.114079_b0200","unstructured":"21CFR, Code of Federal Regulations Title 21. accessdata.fda.gov. (n.d.), 2021."},{"key":"10.1016\/j.addr.2021.114079_b0205","first-page":"5143","article-title":"Polyethylene-glycol suppresses colon cancer and causes dose-dependent regression of azoxymethane-induced aberrant crypt foci in rats","volume":"59","author":"Parnaud","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2021.114079_b0210","first-page":"S11","article-title":"Acute renal insufficiency after colon cleansing","volume":"32","author":"Descamps","year":"2000","journal-title":"Endoscopy"},{"key":"10.1016\/j.addr.2021.114079_b0215","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0196-0644(96)70202-0","article-title":"Acute renal toxicity after ingestion of Lava light liquid","volume":"27","author":"Erickson","year":"1996","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.addr.2021.114079_b0220","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s12264-013-1364-5","article-title":"Polyethylene glycol repairs membrane damage and enhances functional recovery: a tissue engineering approach to spinal cord injury","volume":"29","author":"Shi","year":"2013","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.addr.2021.114079_b0225","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot103176","article-title":"Polyethylene Glycol Fusion for Hybridoma Production","volume":"2018","author":"Greenfield","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.addr.2021.114079_b0230","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/cyto.a.22891","article-title":"High-throughput detection and quantification of mitochondrial fusion through imaging flow cytometry","volume":"89","author":"Nascimento","year":"2016","journal-title":"Cytometry A"},{"key":"10.1016\/j.addr.2021.114079_b0235","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1021\/acsami.9b00704","article-title":"Multimodal Polysilsesquioxane Nanoparticles for Combinatorial Therapy and Gene Delivery in Triple-Negative Breast Cancer","volume":"11","author":"Juneja","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2021.114079_b0240","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201805959","article-title":"RNA Fibers as Optimized Nanoscaffolds for siRNA Coordination and Reduced Immunological Recognition","volume":"28","author":"Rackley","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.addr.2021.114079_b0245","doi-asserted-by":"crossref","first-page":"38873","DOI":"10.1021\/acsami.0c07106","article-title":"Combination of Nucleic Acid and Mesoporous Silica Nanoparticles: Optimization and Therapeutic Performance In Vitro","volume":"12","author":"Juneja","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.addr.2021.114079_b0250","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.biomaterials.2006.08.046","article-title":"Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery","volume":"28","author":"Chan","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0255","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0005-2736(99)00132-7","article-title":"Polyethylene glycol enhances lipoplex-cell association and lipofection","volume":"1421","author":"Ross","year":"1999","journal-title":"BBA"},{"key":"10.1016\/j.addr.2021.114079_b0260","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fphar.2018.00202","article-title":"Poly(Ethylene Glycol)-Polylactide Micelles for Cancer Therapy","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.addr.2021.114079_b0265","doi-asserted-by":"crossref","first-page":"746","DOI":"10.7150\/thno.10732","article-title":"Effect of PEG pairing on the efficiency of cancer-targeting liposomes","volume":"5","author":"Saw","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2021.114079_b0270","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1021\/nn305663e","article-title":"A systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomes","volume":"7","author":"Stefanick","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b0275","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/bit.20160","article-title":"Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production","volume":"86","author":"Bryant","year":"2004","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.114079_b0280","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/bit.22361","article-title":"Hydrogels as extracellular matrix mimics for 3D cell culture","volume":"103","author":"Tibbitt","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.114079_b0285","first-page":"4244","article-title":"Determination of the in vivo degradation mechanism of PEGDA hydrogels","volume":"102","author":"Browning","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2021.114079_b0290","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1073\/pnas.96.6.3104","article-title":"Transdermal photopolymerization for minimally invasive implantation","volume":"96","author":"Elisseeff","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.addr.2021.114079_b0295","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.brainres.2018.10.016","article-title":"Neuro-protective role of nanocapsulated curcumin against cerebral ischemia-reperfusion induced oxidative injury","volume":"1704","author":"Mukherjee","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.addr.2021.114079_b0300","first-page":"187","article-title":"Urticaria as a Rare Side Effect of Polyethylene Glycol-3350 in a Child: Case Report","volume":"57","author":"Sari G\u00f6kay","year":"2018","journal-title":"Acta Clin. Croat."},{"key":"10.1016\/j.addr.2021.114079_b0305","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jaip.2018.12.003","article-title":"Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized","volume":"7","author":"Stone","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.addr.2021.114079_b0310","first-page":"148","article-title":"Urticaria due to polyethylene glycol-3350 and electrolytes for oral solution in a patient with jejunal nodular lymphoid hyperplasia","volume":"28","author":"Zhang","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.addr.2021.114079_b0315","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jaip.2020.11.011","article-title":"Anti-PEG IgE in anaphylaxis associated with polyethylene glycol","volume":"9","author":"Zhou","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.addr.2021.114079_b0320","unstructured":"FDA, Macugen product insert, (2021)."},{"key":"10.1016\/j.addr.2021.114079_b0325","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ajo.2006.10.007","article-title":"Vitreous injections of pegaptanib sodium triggering allergic reactions","volume":"143","author":"Steffensmeier","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.addr.2021.114079_b0330","unstructured":"FDA, Asclera package insert, 2021."},{"key":"10.1016\/j.addr.2021.114079_b0335","unstructured":"FDA, Movantik package insert, 2021."},{"key":"10.1016\/j.addr.2021.114079_b0340","unstructured":"FDA, Palinziq package insert, 2021."},{"key":"10.1016\/j.addr.2021.114079_b0345","unstructured":"WHO, WHO Model List of Essential Medicines. 21st List. , 2019."},{"key":"10.1016\/j.addr.2021.114079_b0350","unstructured":"M.f.M.E.a. Research, Peginterferon ALFA-2A (Subcutaneous route) side effects. Mayo Clinic, (2021)."},{"key":"10.1016\/j.addr.2021.114079_b0355","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.4155\/bio.15.36","article-title":"Anti-PEG antibody bioanalysis: a clinical case study with PEG-IFN-\u03bb-1a and PEG-IFN-\u03b12a in naive patients","volume":"7","author":"Myler","year":"2015","journal-title":"Bioanalysis"},{"key":"10.1016\/j.addr.2021.114079_b0360","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2162-3619-1-10","article-title":"Comparison of safety and toxicity of liposomal doxorubicin vs. conventional anthracyclines: a meta-analysis","volume":"1","author":"Rafiyath","year":"2012","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.addr.2021.114079_b0365","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1208\/s12248-021-00576-y","article-title":"Anthracycline-Induced Cardiotoxicity: Molecular Insights Obtained from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)","volume":"23","author":"Bozza","year":"2021","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2021.114079_b0370","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/ejhpharm-2020-002311","article-title":"Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia: a literature review of pharmaceutical and clinical aspects","volume":"28","author":"Zhu","year":"2020","journal-title":"Eur. J .Hosp. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0375","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.2147\/OTT.S105587","article-title":"Onivyde for the therapy of multiple solid tumors","volume":"9","author":"Zhang","year":"2016","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.addr.2021.114079_b0380","unstructured":"FDA, Onyvide package insert, 2021."},{"issue":"2021","key":"10.1016\/j.addr.2021.114079_b0385","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2217\/nnm-2021-0097","article-title":"an immunotherapy odyssey and the rise of nucleic acid nanotechnology","volume":"16","author":"Panigaj","year":"2021","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.addr.2021.114079_b0390","doi-asserted-by":"crossref","unstructured":"Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine - United States, December 14-23, 2020, MMWR Morb. Mortal. Wkly. Rep. 70 (2021) 46\u201351.","DOI":"10.15585\/mmwr.mm7002e1"},{"key":"10.1016\/j.addr.2021.114079_b0395","doi-asserted-by":"crossref","first-page":"92","DOI":"10.18176\/jiaci.0667","article-title":"Excipients as Potential Agents of Anaphylaxis in Vaccines: Analyzing the Formulations of Currently Authorized COVID-19 Vaccines","volume":"31","author":"Caballero","year":"2021","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b0400","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJMra2035343","article-title":"Maintaining Safety with SARS-CoV-2 Vaccines","volume":"384","author":"Castells","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2021.114079_b0405","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/j.bja.2020.12.020","article-title":"Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?","volume":"126","author":"Garvey","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.addr.2021.114079_b0410","first-page":"1","article-title":"Are the Allergic Reactions of COVID-19 Vaccines Caused by mRNA Constructs or Nanocarriers? Immunological Insights","author":"Selvaraj","year":"2021"},{"key":"10.1016\/j.addr.2021.114079_b0415","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1001\/jama.2021.0600","article-title":"Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine","volume":"325","author":"Shimabukuro","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2021.114079_b0420","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/jama.2021.1967","article-title":"Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US-December 14, 2020-January 18, 2021","volume":"325","author":"Shimabukuro","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2021.114079_b0425","doi-asserted-by":"crossref","DOI":"10.1111\/all.14739","article-title":"EAACI statement on the diagnosis, management and prevention of severe allergic reactions to COVID-19 vaccines","author":"Sokolowska","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.addr.2021.114079_b0430","article-title":"Multisystem Inflammatory Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccination","volume":"27","author":"Salzman","year":"2021","journal-title":"CDC"},{"key":"10.1016\/j.addr.2021.114079_b0435","article-title":"CDC Looks Into Post-COVID Vaccine Heart Inflammation","author":"Crist","year":"2021","journal-title":"WebMD"},{"key":"10.1016\/j.addr.2021.114079_b0440","unstructured":"F. Kawai, Biodegradation of Polyethers (Polyethylene Glycol, Polypropylene Glycol, Polytetramethylene glycol, and Others), Biopolymers Online."},{"key":"10.1016\/j.addr.2021.114079_b0445","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0090-9556(25)09038-5","article-title":"Metabolism and disposition of diethylene glycol in rat and dog","volume":"19","author":"Mathews","year":"1991","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2021.114079_b0450","first-page":"263","article-title":"In vivo per cutaneous absorption of polyoxyethylene lauryl ether surfactants in hairless mice","volume":"34","author":"Nishiyama","year":"1983","journal-title":"J. Soc. Cosmet. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0455","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0041-008X(82)90016-3","article-title":"Toxicity of topical polyethylene glycol","volume":"65","author":"Herold","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2021.114079_b0460","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1177\/1535370214567615","article-title":"Rapid detection of polyethylene glycol sonolysis upon functionalization of carbon nanomaterials","volume":"240","author":"Murali","year":"2015","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.addr.2021.114079_b0465","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.biomaterials.2014.02.029","article-title":"On the biodegradability of polyethylene glycol, polypeptoids and poly(2-oxazoline)s","volume":"35","author":"Ulbricht","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0470","doi-asserted-by":"crossref","first-page":"51e57","DOI":"10.1002\/pol.1960.1204614705","article-title":"Degradation of poly (ethylene oxide)","volume":"46","author":"McGary","year":"1960","journal-title":"J. Polym. Sci"},{"key":"10.1016\/j.addr.2021.114079_b0475","doi-asserted-by":"crossref","first-page":"317e323","DOI":"10.1016\/S0032-3861(97)88175-X","article-title":"Thermal\/oxidative degradation and stabilization of polyethylene glycol","volume":"38","author":"Han","year":"1997","journal-title":"Polymer"},{"key":"10.1016\/j.addr.2021.114079_b0480","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0142-9612(00)00343-4","article-title":"Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture","volume":"22","author":"Branch","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0485","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/jcp.21629","article-title":"Synthetic polymeric substrates as potent pro-oxidant versus anti-oxidant regulators of cytoskeletal remodeling and cell apoptosis","volume":"218","author":"Sung","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.addr.2021.114079_b0490","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/bm201328k","article-title":"Physiologically relevant oxidative degradation of oligo(proline) cross-linked polymeric scaffolds","volume":"12","author":"Yu","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.addr.2021.114079_b0495","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/bc200049d","article-title":"Polyoxazoline: chemistry, properties, and applications in drug delivery","volume":"22","author":"Viegas","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0500","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0168-8278(05)80520-3","article-title":"Hepatic excretion and metabolism of polyethylene glycols and mannitol in the cat","volume":"17","author":"Friman","year":"1993","journal-title":"J. Hepatol."},{"key":"10.1016\/j.addr.2021.114079_b0505","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/0192623318791801","article-title":"Scientific and Regulatory Policy Committee Points to Consider: Histopathologic Evaluation in Safety Assessment Studies for PEGylated Pharmaceutical Products","volume":"46","author":"Irizarry Rovira","year":"2018","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2021.114079_b0510","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/toxsci\/42.2.152","article-title":"Short communication: renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated proteins","volume":"42","author":"Bendele","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0515","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/0192623315591171","article-title":"PEGylated Biopharmaceuticals: Current Experience and Considerations for Nonclinical Development","volume":"43","author":"Ivens","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2021.114079_b0520","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.xphs.2015.11.015","article-title":"PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs","volume":"105","author":"Turecek","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0525","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/0192623317714068","article-title":"Magnetic Resonance and Ultrastructural Characterization of PEGylation-associated Vacuolation in Nonclinical Models","volume":"45","author":"Forest","year":"2017","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.addr.2021.114079_b0530","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.nano.2014.01.009","article-title":"Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles","volume":"10","author":"Dobrovolskaia","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2021.114079_b0535","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nano.2008.08.001","article-title":"Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles","volume":"5","author":"Dobrovolskaia","year":"2009","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2021.114079_b0540","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/acs.molpharmaceut.5b00144","article-title":"Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein","volume":"12","author":"Mima","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0545","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.ijpharm.2012.07.049","article-title":"Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs","volume":"436","author":"Suzuki","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0550","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijpharm.2014.09.047","article-title":"Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin","volume":"476","author":"Suzuki","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0555","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0305-4179(82)90136-X","article-title":"Polyethylene glycol intoxication in burn patients","volume":"9","author":"Bruns","year":"1982","journal-title":"Burns. Incl. Therm. Inj."},{"key":"10.1016\/j.addr.2021.114079_b0560","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23071700","article-title":"Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro","volume":"23","author":"Neun","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.addr.2021.114079_b0565","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3109\/01480545.2010.500292","article-title":"Systemic toxicity and toxicokinetics of a high dose of polyethylene glycol 400 in dogs following intravenous injection","volume":"34","author":"Li","year":"2011","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.addr.2021.114079_b0570","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2168.2001.01608.x","article-title":"Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress","volume":"88","author":"Coskun","year":"2001","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.addr.2021.114079_b0575","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41565-018-0273-1","article-title":"Roadmap and strategy for overcoming infusion reactions to nanomedicines","volume":"13","author":"Szebeni","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2021.114079_b0580","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1021\/acs.chemrev.5b00441","article-title":"Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation","volume":"116","author":"Herzberger","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.addr.2021.114079_b0585","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.polymer.2016.10.015","article-title":"Synthesis of heterobifunctional polyethylene glycols: Polymerization from functional initiators","volume":"105","author":"Vojkovsky","year":"2016","journal-title":"Polymer"},{"key":"10.1016\/j.addr.2021.114079_b0590","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jconrel.2010.02.027","article-title":"A novel size-tunable nanocarrier system for targeted anticancer drug delivery","volume":"144","author":"Li","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0595","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2014.12.008","article-title":"Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy","volume":"199","author":"Pasut","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0600","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.1039\/C8NR00835C","article-title":"Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)","volume":"10","author":"Wang","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2021.114079_b0605","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1021\/acs.nanolett.0c03756","article-title":"Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime","volume":"21","author":"Li","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2021.114079_b0610","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(99)01320-4","article-title":"A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs","volume":"460","author":"Ishida","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2021.114079_b0615","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.1157","article-title":"Recent advances in stealth coating of nanoparticle drug delivery systems","volume":"4","author":"Amoozgar","year":"2012","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.addr.2021.114079_b0620","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1021\/nn502319r","article-title":"Identification of Polyethylene Glycol-Resistant Macrophages on Stealth Imaging in Vitro Using Fluorescent Organosilica Nanoparticles","volume":"9","author":"Nakamura","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b0625","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/088391159701200303","article-title":"Branched and Linear Poly(Ethylene Glycol): Influence of the Polymer Structure on Enzymological, Pharmacokinetic, and Immunological Properties of Protein Conjugates","volume":"12","author":"Veronese","year":"1997","journal-title":"J. Bioactive Compatible Polym."},{"key":"10.1016\/j.addr.2021.114079_b0630","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S1359-6446(05)03575-0","article-title":"PEGylation, successful approach to drug delivery","volume":"10","author":"Veronese","year":"2005","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.addr.2021.114079_b0635","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1021\/bc000082g","article-title":"Rational Design of a Potent, Long-Lasting Form of Interferon: A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon \u03b1-2a for the Treatment of Hepatitis C","volume":"12","author":"Bailon","year":"2001","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0640","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2014.06.046","article-title":"PEG \u2014 A versatile conjugating ligand for drugs and drug delivery systems","volume":"192","author":"Kolate","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0645","doi-asserted-by":"crossref","first-page":"10876","DOI":"10.1021\/ja803688x","article-title":"PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs","volume":"130","author":"Liu","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.addr.2021.114079_b0650","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0169-409X(02)00180-1","article-title":"Effective drug delivery by PEGylated drug conjugates","volume":"55","author":"Greenwald","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b0655","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/bc00031a006","article-title":"A branched monomethoxypoly(ethylene glycol) For protein modification","volume":"6","author":"Monfardini","year":"1995","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0660","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1073\/pnas.0707654105","article-title":"Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy","volume":"105","author":"Liu","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0665","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/ja809086q","article-title":"PEG Branched Polymer for Functionalization of Nanomaterials with Ultralong Blood Circulation","volume":"131","author":"Prencipe","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.addr.2021.114079_b0670","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/bit.21482","article-title":"Size comparison between proteins PEGylated with branched and linear poly(ethylene glycol) molecules","volume":"98","author":"Fee","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.addr.2021.114079_b0675","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/jps.2600830432","article-title":"Distribution and Tissue Uptake of Poly(ethylene glycol) with Different Molecular Weights after Intravenous Administration to Mice","volume":"83","author":"Yamaoka","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0680","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/17425247.2020.1813713","article-title":"Self-assembled non-covalent protein-drug nanoparticles: an emerging delivery platform for anti-cancer drugs","volume":"17","author":"Hassanin","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2021.114079_b0685","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.eurpolymj.2018.04.020","article-title":"In vitro and in vivo biocompatibility study of folate-lysine-PEG-PCL as nanocarrier for targeted breast cancer drug delivery","volume":"103","author":"Zamani","year":"2018","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.addr.2021.114079_b0690","doi-asserted-by":"crossref","first-page":"25831","DOI":"10.3390\/ijms161025831","article-title":"Site-Specific PEGylation of Therapeutic Proteins","volume":"16","author":"Dozier","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0695","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1021\/bc050322y","article-title":"Structure\u2212Function Engineering of Interferon-\u03b2-1b for Improving Stability, Solubility, Potency, Immunogenicity, and Pharmacokinetic Properties by Site-Selective Mono-PEGylation","volume":"17","author":"Basu","year":"2006","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0700","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.copbio.2011.06.012","article-title":"Strategies for extended serum half-life of protein therapeutics","volume":"22","author":"Kontermann","year":"2011","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.addr.2021.114079_b0705","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1021\/acs.jpcb.8b12268","article-title":"Molecular Insight into the Protein-Polymer Interactions in N-Terminal PEGylated Bovine Serum Albumin","volume":"123","author":"Munasinghe","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.addr.2021.114079_b0710","first-page":"271","article-title":"Site-specific conjugation of native antibody","volume":"3","author":"Sadiki","year":"2020","journal-title":"Antib Ther"},{"key":"10.1016\/j.addr.2021.114079_b0715","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s11095-010-0260-1","article-title":"PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications","volume":"27","author":"Yallapu","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.114079_b0720","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1039\/c2cc33600f","article-title":"Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides","volume":"48","author":"Xiong","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.addr.2021.114079_b0725","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1021\/js9800634","article-title":"Attachment of Degradable Poly(Ethylene Glycol) to Proteins has the Potential to Increase Therapeutic Efficacy","volume":"87","author":"Roberts","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0730","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.nano.2014.08.001","article-title":"Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme","volume":"11","author":"Chowdhury","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.addr.2021.114079_b0735","article-title":"Oleanolic acid liposomes with polyethylene glycol modification: promising antitumor drug delivery","volume":"3517","author":"Gao","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b0740","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-5793(90)81016-H","article-title":"Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes","volume":"268","author":"Klibanov","year":"1990","journal-title":"FEBS Lett."},{"key":"10.1016\/j.addr.2021.114079_b0745","doi-asserted-by":"crossref","first-page":"49858","DOI":"10.1002\/app.49858","article-title":"Methoxy polyethylene glycol\u2013cholesterol modified soy lecithin liposomes for poorly water-soluble anticancer drug delivery","volume":"138","author":"Le","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0750","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1023\/A:1020488012264","article-title":"Polyethylene Glycol-Diacyllipid Micelles Demonstrate Increased Acculumation in Subcutaneous Tumors in Mice","volume":"19","author":"Lukyanov","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.114079_b0755","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2165\/00003495-199700544-00004","article-title":"Liposomes","volume":"54","author":"Allen","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.addr.2021.114079_b0760","first-page":"17","article-title":"Bioresponsive materials","volume":"2","author":"Lu","year":"2017","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.addr.2021.114079_b0765","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/138920012798356934","article-title":"PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery","volume":"13","author":"Milla","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.addr.2021.114079_b0770","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/2018\/1575438","article-title":"Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery","volume":"2018","author":"Nguyen","year":"2018","journal-title":"Int. J. Biomater."},{"key":"10.1016\/j.addr.2021.114079_b0775","article-title":"Effect of protein adsorption on cell uptake and blood clearance of methoxy poly(ethylene glycol)-poly(caprolactone) nanoparticles","volume":"133","author":"Li","year":"2016","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0780","doi-asserted-by":"crossref","first-page":"47854","DOI":"10.1002\/app.47854","article-title":"Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle","volume":"136","author":"Shan","year":"2019","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0785","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1039\/c0cs00227e","article-title":"Tailoring nanocarriers for intracellular protein delivery","volume":"40","author":"Gu","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.addr.2021.114079_b0790","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3390\/polym11091515","article-title":"Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma","volume":"11","author":"Cadinoiu","year":"2019","journal-title":"Polymers"},{"key":"10.1016\/j.addr.2021.114079_b0795","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2217\/nnm.10.122","article-title":"Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats","volume":"6","author":"Lankveld","year":"2011","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.addr.2021.114079_b0800","doi-asserted-by":"crossref","first-page":"6574","DOI":"10.1016\/j.biomaterials.2010.05.009","article-title":"Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection","volume":"31","author":"Lipka","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0805","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1021\/nn304347g","article-title":"Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice","volume":"6","author":"Jokerst","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b0810","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41467-017-00622-4","article-title":"A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol","volume":"8","author":"Chang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2021.114079_b0815","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12010015","article-title":"Both IgM and IgG Antibodies Against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice","volume":"12","author":"Chang","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2021.114079_b0820","doi-asserted-by":"crossref","first-page":"10661","DOI":"10.1021\/acs.analchem.6b03109","article-title":"Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals","volume":"88","author":"Chen","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0825","doi-asserted-by":"crossref","first-page":"7808","DOI":"10.1021\/acsnano.9b07218","article-title":"Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex","volume":"14","author":"Chen","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b0830","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.toxrep.2020.12.022","article-title":"Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma","volume":"8","author":"Fang","year":"2021","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.addr.2021.114079_b0835","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.ultrasmedbio.2018.02.006","article-title":"Accelerated Clearance of Ultrasound Contrast Agents Containing Polyethylene Glycol is Associated with the Generation of Anti-Polyethylene Glycol Antibodies","volume":"44","author":"Fix","year":"2018","journal-title":"Ultrasound. Med. Biol."},{"key":"10.1016\/j.addr.2021.114079_b0840","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.actbio.2016.07.019","article-title":"Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus","volume":"43","author":"Henry","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2021.114079_b0845","doi-asserted-by":"crossref","unstructured":"A. Khalil, G. W\u00fcrthwein, J. Golitsch, G. Hempel, M. Fobker, J. Gerss, A. M\u00f6ricke, M. Zimmermann, P. Smisek, M. Zucchetti, C. Nath, A. Attarbaschi, A. Von Stackelberg, N. G\u00f6kbuget, C. Rizzari, V. Conter, M. Schrappe, J. Boos, C. Lanvers-Kaminsky, Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia, Haematologica, Online ahead of print (2020).","DOI":"10.3324\/haematol.2020.258525"},{"key":"10.1016\/j.addr.2021.114079_b0850","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.addr.2020.07.024","article-title":"Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals","volume":"154\u2013155","author":"Kozma","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b0855","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s11095-016-1961-x","article-title":"The Mystery of Antibodies Against Polyethylene Glycol (PEG) - What do we Know?","volume":"33","author":"Lubich","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.114079_b0860","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1021\/acsbiomaterials.7b00147","article-title":"Cross-Reactivity of Select PEG-Binding Antibodies to Other Polymers Containing a C-C-O Backbone","volume":"3","author":"McCallen","year":"2017","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.addr.2021.114079_b0865","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejps.2016.06.007","article-title":"Impact of anti-PEG IgM antibodies on the pharmacokinetics of pegylated asparaginase preparations in mice","volume":"91","author":"Poppenborg","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0870","doi-asserted-by":"crossref","first-page":"11804","DOI":"10.1021\/acs.analchem.6b03437","article-title":"Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population","volume":"88","author":"Yang","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.addr.2021.114079_b0875","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/wnan.1339","article-title":"Anti-PEG immunity: emergence, characteristics, and unaddressed questions","volume":"7","author":"Yang","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.addr.2021.114079_b0880","unstructured":"USFDA, Guidance for Industry Immunogenicity Assessment for Therapeutic Protein Products, 2014."},{"key":"10.1016\/j.addr.2021.114079_b0885","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.01.005","article-title":"Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes","volume":"112","author":"Ishida","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0890","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ijpharm.2010.03.022","article-title":"T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes","volume":"392","author":"Koide","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0895","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jconrel.2009.04.006","article-title":"Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production","volume":"137","author":"Tagami","year":"2009","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0900","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jconrel.2009.10.017","article-title":"CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes","volume":"142","author":"Tagami","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0905","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2010.12.013","article-title":"Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA","volume":"151","author":"Tagami","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0910","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0022-3565(24)39325-5","article-title":"Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose","volume":"293","author":"Laverman","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2021.114079_b0915","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3565(24)29419-2","article-title":"Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection","volume":"298","author":"Laverman","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2021.114079_b0920","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1002\/jps.22682","article-title":"Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance","volume":"100","author":"Kaminskas","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2021.114079_b0925","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2005.01.008","article-title":"Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats","volume":"104","author":"Wang","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0930","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ijpharm.2008.06.004","article-title":"Particle size-dependent triggering of accelerated blood clearance phenomenon","volume":"362","author":"Koide","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0935","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-3659(02)00462-5","article-title":"Accelerated clearance of PEGylated liposomes in rats after repeated injections","volume":"88","author":"Ishida","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0940","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jconrel.2005.04.003","article-title":"Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes","volume":"105","author":"Ishida","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0945","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jconrel.2006.08.017","article-title":"Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection","volume":"115","author":"Ishida","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0950","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jconrel.2003.12.011","article-title":"Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice","volume":"95","author":"Ishida","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0955","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jconrel.2007.11.009","article-title":"The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats","volume":"126","author":"Ishida","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0960","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2007.11.005","article-title":"Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes","volume":"354","author":"Ishida","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b0965","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jconrel.2007.05.015","article-title":"PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner","volume":"122","author":"Ishida","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b0970","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1021\/bm100754e","article-title":"Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers","volume":"11","author":"Ishihara","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.addr.2021.114079_b0975","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1007\/s11095-009-9943-x","article-title":"Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles","volume":"26","author":"Ishihara","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2021.114079_b0980","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0022-3565(24)35391-1","article-title":"Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes","volume":"292","author":"Dams","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2021.114079_b0985","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/08982109809035531","article-title":"Repeat Injection Studies of Technetium-99M-Labeled Peg-Liposomes in the Same Animal","volume":"8","author":"Coins","year":"1998","journal-title":"J Liposome Research"},{"key":"10.1016\/j.addr.2021.114079_b0990","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.biomaterials.2007.10.015","article-title":"Complement activation on surfaces modified with ethylene glycol units","volume":"29","author":"Arima","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b0995","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/bc200551b","article-title":"Role of the methoxy group in immune responses to mPEG-protein conjugates","volume":"23","author":"Sherman","year":"2012","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.addr.2021.114079_b1000","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-5710(98)00039-5","article-title":"PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques","volume":"68","author":"Francis","year":"1998","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.addr.2021.114079_b1005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000233512","article-title":"Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors","volume":"74","author":"Richter","year":"1984","journal-title":"Int. Arch. Allergy. Appl. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1010","article-title":"Normal donor sera contain antibodies tp polyethyleneglycol (PEG)","volume":"41","author":"Leger","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.addr.2021.114079_b1015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cncr.22739","article-title":"Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients","volume":"110","author":"Armstrong","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.addr.2021.114079_b1020","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/ar1861","article-title":"Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase","volume":"8","author":"Ganson","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.addr.2021.114079_b1025","article-title":"Occurance of an antibody to poly(ethylene glycol) in normal donors","volume":"102","author":"Armstrong","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.addr.2021.114079_b1030","unstructured":"E. Chen, B.M. Chen, Y.C. Su, Y.C. Chang, T.L. Cheng, Y. Barenholz, S.R. Roffler, Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex, ACS Nano, (https:\/\/dx.doi.org\/10.1021\/acsnano.9b07218) (2020) (https:\/\/dx.doi.org\/10.1021\/acsnano.1029b07218)."},{"key":"10.1016\/j.addr.2021.114079_b1035","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2016.07.019","article-title":"Anti-PEG antibodies alter the mobility and biodistribution of densely PEGylated nanoparticles in mucus","author":"Henry","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2021.114079_b1040","doi-asserted-by":"crossref","DOI":"10.3390\/polym12020298","article-title":"The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation","volume":"12","author":"Hoang Thi","year":"2020","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.addr.2021.114079_b1045","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jconrel.2016.06.040","article-title":"Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation","volume":"244","author":"Zhang","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1050","doi-asserted-by":"crossref","first-page":"11386","DOI":"10.1021\/acsnano.8b06266","article-title":"Theranostic Imaging May Vaccinate against the Therapeutic Benefit of Long Circulating PEGylated Liposomes and Change Cargo Pharmacokinetics","volume":"12","author":"Borresen","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b1055","first-page":"710","article-title":"PEGylated liposomes: immunological responses, Sci Technol","volume":"20","author":"Mohamed","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.addr.2021.114079_b1060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/1043454217741868","article-title":"Clinical Characteristics of Intravenous PEG-Asparaginase Hypersensitivity Reactions in Patients Undergoing Treatment for Acute Lymphoblastic Leukemia [Formula: see text]","volume":"35","author":"Browne","year":"2018","journal-title":"J. Pediatr. Oncol. Nurs."},{"key":"10.1016\/j.addr.2021.114079_b1065","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/pbc.25319","article-title":"Nordic Society of Paediatric, g. Oncology, PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol","volume":"62","author":"Henriksen","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.addr.2021.114079_b1070","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/1078155214542493","article-title":"Delayed hypersensitivity reaction related to the use of pegfilgrastim","volume":"21","author":"Dadla","year":"2015","journal-title":"J. Oncol. Pharmacy Practice : Off. Publ. Int. Soc. Oncol. Pharmacy Practitioners"},{"key":"10.1016\/j.addr.2021.114079_b1075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2215\/CJN.03570417","article-title":"Efficacy and Long-Term Safety of C.E.R.A. Maintenance in Pediatric Hemodialysis Patients with Anemia of CKD","volume":"13","author":"Fischbach","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.addr.2021.114079_b1080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jim.2019.03.004","article-title":"Depletion of interfering IgG and IgM is critical to determine the role of IgE in pegvaliase-associated hypersensitivity","volume":"468","author":"Larimore","year":"2019","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.addr.2021.114079_b1085","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/pds.3655","article-title":"Relative safety of peginesatide and epoetin alfa","volume":"23","author":"Weinhandl","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.addr.2021.114079_b1090","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13075-017-1396-8","article-title":"Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout","volume":"19","author":"Calabrese","year":"2017","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.addr.2021.114079_b1095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.10.034","article-title":"Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer","volume":"137","author":"Ganson","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1100","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.jaci.2016.04.058","article-title":"Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer","volume":"138","author":"Povsic","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1105","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/eurheartj\/ehs232","article-title":"A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial","volume":"34","author":"Povsic","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.addr.2021.114079_b1110","article-title":"Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes","author":"Staudacher","year":"2017","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.addr.2021.114079_b1115","unstructured":"J. Carrol, Top 10 Phase III disasters of 2014, Fierce Biotech, 2014."},{"key":"10.1016\/j.addr.2021.114079_b1120","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1002\/art.23810","article-title":"Pegloticase Phase 2 Study, Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study","volume":"58","author":"Sundy","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.addr.2021.114079_b1125","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/ar4500","article-title":"Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients","volume":"16","author":"Hershfield","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.addr.2021.114079_b1130","first-page":"71","article-title":"withdrawal of its European marketing authorisation is welcome","volume":"26","author":"Prescrire","year":"2017","journal-title":"Prescrire Int"},{"key":"10.1016\/j.addr.2021.114079_b1135","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1572-0241.2003.07457.x","article-title":"The incidence and management of infusion reactions to infliximab: a large center experience","volume":"98","author":"Cheifetz","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.addr.2021.114079_b1140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1634\/theoncologist.12-5-601","article-title":"Management and preparedness for infusion and hypersensitivity reactions","volume":"12","author":"Lenz","year":"2007","journal-title":"Oncologist"},{"key":"10.1016\/j.addr.2021.114079_b1145","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.gtc.2006.09.006","article-title":"Infusion reactions and their management","volume":"35","author":"Mayer","year":"2006","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.addr.2021.114079_b1150","first-page":"E10-E 21","article-title":"Infusion reactions: Diagnosing, Asessment and management","volume":"14","author":"Vogel","year":"2010","journal-title":"Clin. J. Oncol. Nursing"},{"key":"10.1016\/j.addr.2021.114079_b1155","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.2217\/imt-2017-0111","article-title":"Oral immunotherapy using polymeric nanoparticles loaded with peanut proteins in a murine model of fatal anaphylaxis","volume":"9","author":"Gamazo","year":"2017","journal-title":"Immunotherapy"},{"key":"10.1016\/j.addr.2021.114079_b1160","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2014.08.009","article-title":"Features of complement activation-related pseudoallergy to liposomes with different surface charge and PEGylation: comparison of the porcine and rat responses","volume":"195","author":"Dezsi","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1165","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24183283","article-title":"Complement Activation-Related Pathophysiological Changes in Anesthetized Rats: Activator-Dependent Variations of Symptoms and Mediators of Pseudoallergy","volume":"24","author":"Dezsi","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.addr.2021.114079_b1170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1515\/ejnm-2015-0022","article-title":"Paradoxical rise of hemolytic complement in the blood of mice during zymosan- and liposome induced CARPA: a pilot study","volume":"7","author":"M\u00e9sz\u00e1ros","year":"2015","journal-title":"Eur. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b1175","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2147\/IJN.S187139","article-title":"Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice","volume":"14","author":"Orfi","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b1180","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2174\/156720105774370212","article-title":"Complement activation-related pseudoallergy caused by amphiphilic drug carriers: the role of lipoproteins","volume":"2","author":"Szebeni","year":"2005","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.addr.2021.114079_b1185","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.molimm.2011.06.377","article-title":"Complement mediated hypersensitivity to nanomedicines","volume":"48","author":"Szebeni","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2014.06.038","article-title":"Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals","volume":"61","author":"Szebeni","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10731199909117481","article-title":"Complement-mediated acute effects of liposome-encapsulated hemoglobin","volume":"27","author":"Szebeni","year":"1999","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.addr.2021.114079_b1200","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.addr.2012.07.005","article-title":"A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines","volume":"64","author":"Szebeni","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b1205","doi-asserted-by":"crossref","first-page":"63","DOI":"10.29016\/180427.1","article-title":"A porcine model of complement activation-related pseudoallergy to nano-pharmaceuticals: Pros and cons of translation to a preclinical safety test","volume":"1","author":"Szebeni","year":"2018","journal-title":"Prec. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b1210","doi-asserted-by":"crossref","unstructured":"L. D\u00e9zsi, G. Sz\u00e9n\u00e1si, R. Urbanics, L. Rosivall, J. Szebeni, Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy, (2013).","DOI":"10.4236\/health.2013.56138"},{"key":"10.1016\/j.addr.2021.114079_b1215","first-page":"109","article-title":"Mechanisms of leukocyte regulation by complement-derived factors","volume":"14","author":"Hugli","year":"1984","journal-title":"Contemp. Top. Immunobiol."},{"issue":"Suppl 1","key":"10.1016\/j.addr.2021.114079_b1220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000232882","article-title":"Possible role of serum anaphylatoxins in hypersensitivity reactions","volume":"66","author":"Hugli","year":"1981","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1225","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/00005373-198412000-00006","article-title":"Anaphylatoxin generation in multisystem organ failure","volume":"24","author":"Heideman","year":"1984","journal-title":"J. Trauma"},{"key":"10.1016\/j.addr.2021.114079_b1230","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1164\/ajrccm\/136.2.459","article-title":"Complement activation and membrane lipids in lung vascular injury","volume":"136","author":"Lundberg","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.addr.2021.114079_b1235","first-page":"471","article-title":"C5a-induced hemodynamic and hematologic changes in the rabbit. Role of cyclooxygenase products and polymorphonuclear leukocytes","volume":"128","author":"Lundberg","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.addr.2021.114079_b1240","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0162-3109(87)90031-2","article-title":"Effects of anaphylatoxins on circulation","volume":"14","author":"Marceau","year":"1987","journal-title":"Immunopharmacol"},{"key":"10.1016\/j.addr.2021.114079_b1245","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v15.i1.20","article-title":"The interaction of liposomes with the complement system","volume":"15","author":"Szebeni","year":"1998","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2021.114079_b1250","series-title":"The Complement System: Novel Roles in Health and Disease","first-page":"512","author":"Szebeni","year":"2004"},{"key":"10.1016\/j.addr.2021.114079_b1255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/1-4020-8056-5_17","article-title":"Complement Activation-Related Pseudoallergy","author":"Szebeni","year":"2004","journal-title":"Complement Syst."},{"key":"10.1016\/j.addr.2021.114079_b1260","first-page":"15","article-title":"Nanomedicine: application of nanotechnology in medicine. Opportunities in neuropsychiatry","volume":"13","author":"Szebeni","year":"2011","journal-title":"Neuropsychopharmacol. Hung."},{"key":"10.1016\/j.addr.2021.114079_b1265","series-title":"Handbook of Nanobiomedical Research","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1142\/9789814520652_0053","article-title":"Immunological Issues with Nanomedicines: Immunogenicity, Hypersensitivity, Accelerated Clearance and Immune Suppression","author":"Szebeni","year":"2014"},{"key":"10.1016\/j.addr.2021.114079_b1270","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.addr.2011.06.017","article-title":"Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention","volume":"63","author":"Szebeni","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b1275","doi-asserted-by":"crossref","first-page":"9315","DOI":"10.1021\/acsnano.9b03942","article-title":"Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions","volume":"13","author":"Kozma","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b1280","doi-asserted-by":"crossref","first-page":"102366","DOI":"10.1016\/j.nano.2021.102366","article-title":"Complement-mediated hypersensitivity reactions to an amphotericin B-containing lipid complex (Abelcet) in pediatric patients and anesthetized rats: Benefits of slow infusion","volume":"34","author":"Milosevits","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.addr.2021.114079_b1285","unstructured":"J. Szebeni, The Complement System and the Kidney: Interplays in Health and Disease, Nephrology, Hypertension, Dialysis, Transplantation, (2006) 123."},{"key":"10.1016\/j.addr.2021.114079_b1290","first-page":"1","article-title":"Interactions of Liposomes with Complement Leading to Adverse Reactions","volume":"3","author":"Szebeni","year":"2006","journal-title":"Liposome Technol. Volume III: Interact. Liposomes Biol. Milieu"},{"key":"10.1016\/j.addr.2021.114079_b1295","doi-asserted-by":"crossref","first-page":"H1050","DOI":"10.1152\/ajpheart.00622.2005","article-title":"Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function","volume":"290","author":"Szebeni","year":"2006","journal-title":"Am. J. Physiol. Heart Circ Physiol."},{"key":"10.1016\/j.addr.2021.114079_b1300","first-page":"171","article-title":"Complement activation during heart surgery with cardiopulmonary bypass: lack of correlation between soluble terminal complex formation and inflammatory cell response","author":"Szebeni","year":"2006","journal-title":"Mol. Immunol., Pergamon-Elsevier Science Ltd The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB England"},{"key":"10.1016\/j.addr.2021.114079_b1305","first-page":"e37","article-title":"Maintaining Safety with SARS-CoV-2 Vaccines","volume":"384","author":"Castells","year":"2021","journal-title":"Reply, N Engl. J. Med."},{"key":"10.1016\/j.addr.2021.114079_b1310","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2021.03.073","article-title":"Anaphylactic reactions to mRNA COVID-19 vaccines: A call for further study","author":"Hatziantoniou","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.addr.2021.114079_b1315","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.vaccine.2020.12.084","article-title":"Anaphylactic reactions to novel mRNA SARS-CoV-2\/COVID-19 vaccines","volume":"39","author":"Kelso","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.addr.2021.114079_b1320","doi-asserted-by":"crossref","DOI":"10.1007\/s40629-021-00165-7","article-title":"Practical handling of allergic reactions to COVID-19 vaccines","author":"Klimek","year":"2021","journal-title":"Allergo J. Int."},{"key":"10.1016\/j.addr.2021.114079_b1325","article-title":"Disproportionality Analysis of Anaphylactic Reactions after Vaccination with mRNA COVID-19 Vaccines in the United States","author":"Rodriguez-Nava","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1330","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jconrel.2015.12.032","article-title":"Materials for non-viral intracellular delivery of messenger RNA therapeutics","volume":"240","author":"Kauffman","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1335","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1046\/j.1365-2133.2000.03843.x","article-title":"Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation","volume":"143","author":"R\u00f6nnau","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2021.114079_b1340","doi-asserted-by":"crossref","first-page":"394","DOI":"10.18176\/jiaci.0109","article-title":"Anaphylaxis Due to the Excipient Polysorbate 80","volume":"26","author":"Palacios Casta\u00f1o","year":"2016","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1345","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1600-0536.2007.01020.x","article-title":"Independent sensitization to polidocanol and trometamol or glycerol within same product","volume":"56","author":"Fairhurst","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.addr.2021.114079_b1350","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-0536.2006.01027.x","article-title":"Allergic contact dermatitis due to 1,3-butylene glycol and glycerol","volume":"56","author":"Tamagawa-Mineoka","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.addr.2021.114079_b1355","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0536.2007.01247.x","article-title":"A case of allergic contact dermatitis to polyglyceryl laurate","volume":"58","author":"Washizaki","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.addr.2021.114079_b1360","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.biomaterials.2016.06.002","article-title":"A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity","volume":"101","author":"He","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b1365","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1021\/acsnano.8b01806","article-title":"C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes","volume":"12","author":"Tavano","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2021.114079_b1370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.06.023","article-title":"The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes","volume":"213","author":"Kierstead","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1375","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/cryo.2000.2247","article-title":"Effects of high-molecular-weight cryoprotectants on platelets and the coagulation system","volume":"40","author":"Bakaltcheva","year":"2000","journal-title":"Cryobiology"},{"key":"10.1016\/j.addr.2021.114079_b1380","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0887-7963(03)00040-3","article-title":"Effects of blood product storage protectants on blood coagulation","volume":"17","author":"Bakaltcheva","year":"2003","journal-title":"Transfus. Med. Rev."},{"key":"10.1016\/j.addr.2021.114079_b1385","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/pr.115.011247","article-title":"Pharmacology of Heparin and Related Drugs","volume":"68","author":"Mulloy","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.addr.2021.114079_b1390","unstructured":"FDA, ImmunogenicityRelated Considerations for Low Molecular Weight Heparin Guidance for Industry, 2016."},{"key":"10.1016\/j.addr.2021.114079_b1395","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.med.042808.171814","article-title":"Heparin-induced thrombocytopenia","volume":"61","author":"Arepally","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.addr.2021.114079_b1400","doi-asserted-by":"crossref","first-page":"e1112","DOI":"10.1097\/GOX.0000000000001112","article-title":"Two Cases of Adverse Reactions of Hyaluronic Acid-based Filler Injections","volume":"4","author":"Fan","year":"2016","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"10.1016\/j.addr.2021.114079_b1405","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/jocd.14074","article-title":"Hypersensitivity reaction to Hyaluronic Acid Dermal filler following novel Coronavirus infection - a case report","volume":"20","author":"Rowland-Warmann","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.addr.2021.114079_b1410","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/CCID.S198081","article-title":"Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness","volume":"12","author":"Turkmani","year":"2019","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.addr.2021.114079_b1415","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jconrel.2013.09.010","article-title":"Differential immunotoxicities of poly(ethylene glycol)- vs. poly(carboxybetaine)-coated nanoparticles","volume":"172","author":"Elsabahy","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1420","doi-asserted-by":"crossref","first-page":"13873","DOI":"10.1002\/anie.201808615","article-title":"Revealing the Immunogenic Risk of Polymers","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.addr.2021.114079_b1425","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.2147\/IJN.S230865","article-title":"In vivo Studies on Pharmacokinetics, Toxicity and Immunogenicity of Polyelectrolyte Nanocapsules Functionalized with Two Different Polymers: Poly-L-Glutamic Acid or PEG","volume":"14","author":"Karabasz","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b1430","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1346-8138.2011.01282.x","article-title":"Involvement of poly (\u03b3-glutamic acid) as an allergen in late-onset anaphylaxis due to fermented soybeans (natto)","volume":"39","author":"Inomata","year":"2012","journal-title":"J. Dermatol."},{"key":"10.1016\/j.addr.2021.114079_b1435","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2332\/allergolint.10-CR-0267","article-title":"Late-onset anaphylaxis due to poly (\u03b3-glutamic acid) in the soup of commercial cold Chinese noodles in a patient with allergy to fermented soybeans (natto)","volume":"60","author":"Inomata","year":"2011","journal-title":"Allergol. Int."},{"key":"10.1016\/j.addr.2021.114079_b1440","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jmv.21029","article-title":"Poly(gamma-glutamic acid) nanoparticles as an efficient antigen delivery and adjuvant system: potential for an AIDS vaccine","volume":"80","author":"Wang","year":"2008","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.addr.2021.114079_b1445","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-5173(01)00603-2","article-title":"The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implication in its pharmacokinetics","volume":"217","author":"Fernandes","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b1450","doi-asserted-by":"crossref","first-page":"962","DOI":"10.7150\/thno.19061","article-title":"Development of Sialic Acid-coated Nanoparticles for Targeting Cancer and Efficient Evasion of the Immune System","volume":"7","author":"Kim","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2021.114079_b1455","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nchembio.1696","article-title":"Structural basis for sialic acid-mediated self-recognition by complement factor H","volume":"11","author":"Blaum","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.addr.2021.114079_b1460","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2311-z","article-title":"Sialylation of immunoglobulin E is a determinant of allergic pathogenicity","volume":"582","author":"Shade","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.addr.2021.114079_b1465","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jnc.13121","article-title":"Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders","volume":"134","author":"Watzlawik","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.addr.2021.114079_b1470","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0536.1988.tb02874.x","article-title":"Contact dermatitis from acrylamide","volume":"19","author":"Lambert","year":"1988","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.addr.2021.114079_b1475","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/jbm.a.34853","article-title":"Poly(N-acryloylmorpholine): a simple hydrogel system for temporal and spatial control over cell adhesion","volume":"102","author":"Gorman","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2021.114079_b1480","unstructured":"PubChem, PubChem Compound Summary for CID 98723, 4-Acryloylmorpholine, in: N.C.f.B.I. National Library of Medicine (US) (Ed.)Bethesda (MD), 2021."},{"key":"10.1016\/j.addr.2021.114079_b1485","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.bmc.2017.09.016","article-title":"Prospects of PASylation\u00ae for the design of protein and peptide therapeutics with extended half-life and enhanced action","volume":"26","author":"Gebauer","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.addr.2021.114079_b1490","series-title":"Engineering of Biomaterials for Drug Delivery Systems","first-page":"299","article-title":"11 - Polypeptides: PASylation and XTEN","author":"Anand","year":"2018"},{"key":"10.1016\/j.addr.2021.114079_b1495","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/app7010049","article-title":"FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol","volume":"7","author":"Le\u00f3n","year":"2017","journal-title":"Appl. Sci."},{"key":"10.1016\/j.addr.2021.114079_b1500","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0168-3659(01)00218-8","article-title":"PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats","volume":"71","author":"Li","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1505","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2009.08.024","article-title":"Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles","volume":"141","author":"Hong","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1510","doi-asserted-by":"crossref","first-page":"104467","DOI":"10.1016\/j.microc.2019.104467","article-title":"Site-Specific characterization of peptide-polymer conjugates in various stoichiometries by MALDI-Tandem mass spectrometry","volume":"152","author":"\u00dclk\u00fc","year":"2020","journal-title":"Microchem. J."},{"key":"10.1016\/j.addr.2021.114079_b1515","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/masy.19961100117","article-title":"Characterization of polyethers using different methods: SFC, LAC and SEC with different detectors, and MALDI-TOF-MS","volume":"110","author":"Trathnigg","year":"1996","journal-title":"Macromol. Symposia"},{"key":"10.1016\/j.addr.2021.114079_b1520","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1039\/D0PY01493A","article-title":"A study of the application of graphite MALDI to the analysis of short-chain polyethylene glycols","volume":"12","author":"Conway","year":"2021","journal-title":"Polym. Chem."},{"key":"10.1016\/j.addr.2021.114079_b1525","doi-asserted-by":"crossref","first-page":"7748","DOI":"10.1016\/j.biomaterials.2010.06.053","article-title":"Transferrin-conjugated nanoparticles of Poly(lactide)-d-\u03b1-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood\u2013brain barrier","volume":"31","author":"Gan","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2021.114079_b1530","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijpharm.2018.05.052","article-title":"Pentaglycine lipid derivates \u2013 rp-HPLC analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems","volume":"547","author":"W\u00f6ll","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b1535","article-title":"An efficient PEGylated liposomal nanocarrier containing cell-penetrating peptide and pH-sensitive hydrazone bond for enhancing tumor-targeted drug delivery","volume":"6199","author":"Xie","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2021.114079_b1540","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3390\/molecules26051435","article-title":"Rp-HPLC Determination of Quercetin in a Novel D-\u03b1-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma","volume":"26","author":"Ahmed","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.addr.2021.114079_b1545","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1021\/la011393y","article-title":"Poly(lactic acid)\u2212Poly(ethylene oxide) (PLA\u2212PEG) Nanoparticles: NMR Studies of the Central Solidlike PLA Core and the Liquid PEG Corona","volume":"18","author":"Heald","year":"2002","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2021.114079_b1550","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0939-6411(03)00193-0","article-title":"Comparison of scanning electron microscopy, dynamic light scattering and analytical ultracentrifugation for the sizing of poly(butyl cyanoacrylate) nanoparticles","volume":"57","author":"Bootz","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2021.114079_b1555","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ijpharm.2010.10.025","article-title":"Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles","volume":"403","author":"Crawford","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2021.114079_b1560","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1251652","article-title":"The Resolution Revolution","volume":"343","author":"Kuhlbrandt","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.addr.2021.114079_b1565","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2018.09.012","article-title":"Animal models for analysis of immunological responses to nanomaterials: Challenges and considerations","author":"Zamboni","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2021.114079_b1570","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41565-018-0273-1","article-title":"Roadmap and strategy for overcoming infusion reactions to nanomedicines","volume":"13","author":"Szebeni","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2021.114079_b1575","doi-asserted-by":"crossref","first-page":"584966","DOI":"10.3389\/fimmu.2020.584966","article-title":"The Critical Choice of Animal Models in Nanomedicine Safety Assessment: A Lesson Learned From Hemoglobin-Based Oxygen Carriers","volume":"11","author":"Bed\u0151cs","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1580","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jconrel.2017.11.043","article-title":"Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model: Correlation with physicochemical features and clinical information","volume":"270","author":"F\u00fcl\u00f6p","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2021.114079_b1585","unstructured":"B. Neun, M.A. Dobrovolskaia, NCL Method ITA-36: Detection of naturally occurring antibodies to PEG and PEGylated liposomes in plasma of human donor volunteers, 2020."},{"key":"10.1016\/j.addr.2021.114079_b1590","doi-asserted-by":"crossref","DOI":"10.3791\/1923","article-title":"Measuring the 50% haemolytic complement (CH50) activity of serum","author":"Costabile","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.addr.2021.114079_b1595","unstructured":"B. Neun, E. Cedrone, M. Dobrovolskaia, NCL Method ITA-5.2: Analysis of complement activation by single-plex EIA or multiplex ELISA. , ELISA. https:\/\/ncl.cancer.gov\/resources\/assaycascade-protocols (2020)."},{"key":"10.1016\/j.addr.2021.114079_b1600","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1128\/CDLI.6.1.137-139.1999","article-title":"Comparison of three different methods for measuring classical pathway complement activity","volume":"6","author":"Jaskowski","year":"1999","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1605","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23010012","article-title":"Anticoagulants Influence the Performance of In Vitro Assays Intended for Characterization of Nanotechnology-Based Formulations","volume":"23","author":"Cedrone","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.addr.2021.114079_b1610","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1084\/jem.161.6.1357","article-title":"Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone","volume":"161","author":"Braley-Mullen","year":"1985","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.addr.2021.114079_b1615","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/intimm\/6.6.805","article-title":"Requirement for B cell-derived immunoglobulin for Th activation by the type 2 antigen polyvinylpyrrolidone","volume":"6","author":"Braley-Mullen","year":"1994","journal-title":"Int. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1620","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4049\/jimmunol.139.5.1400","article-title":"In vitro activation of specific helper and suppressor T cells by the type 2 antigen polyvinylpyrrolidone","volume":"139","author":"Van Buskirk","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1625","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.4049\/jimmunol.138.4.1031","article-title":"Characterization of helper T cells induced by the type 2 antigen polyvinylpyrrolidone","volume":"138","author":"Van Buskirk","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2021.114079_b1630","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1517\/17425247.2015.1042857","article-title":"Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics","volume":"12","author":"Dobrovolskaia","year":"2015","journal-title":"Expert Opin. Drug. Deliv."},{"key":"10.1016\/j.addr.2021.114079_b1635","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2015.12.022","article-title":"Current understanding of interactions between nanoparticles and the immune system","volume":"299","author":"Dobrovolskaia","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2021.114079_b1640","series-title":"Cellular and Molecular Immunology","first-page":"279","article-title":"Effector mechanisms of immunoglobulin E-initiated immune reactions","author":"Abbas","year":"1994"},{"key":"10.1016\/j.addr.2021.114079_b1645","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/wnan.1339","article-title":"Anti-PEG immunity: emergence, characteristics, and unaddressed questions","volume":"7","author":"Yang","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.addr.2021.114079_b1650","series-title":"Cellular and molecular immunology","author":"Abbas","year":"2018"},{"key":"10.1016\/j.addr.2021.114079_b1655","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00005-012-0189-7","article-title":"Immunogenicity to biologics: mechanisms, prediction and reduction","volume":"60","author":"Sethu","year":"2012","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.addr.2021.114079_b1660","unstructured":"Labcorp, Allergen panels, 2021."},{"key":"10.1016\/j.addr.2021.114079_b1665","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.ddtec.2009.02.002","article-title":"PEGylation: Posttranslational bioengineering of protein biotherapeutics","volume":"5","author":"Veronese","year":"2008","journal-title":"Drug Discovery Today: Technol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21004725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X21004725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:15:49Z","timestamp":1759209349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X21004725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":333,"alternative-id":["S0169409X21004725"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2021.114079","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"To PEGylate or not to PEGylate: Immunological properties of nanomedicine\u2019s most popular component, polyethylene glycol and its alternatives","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2021.114079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114079"}}