{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:05:28Z","timestamp":1792623928771,"version":"4.5.0"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.addr.2023.115007","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T07:59:07Z","timestamp":1689494347000},"page":"115007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems"],"prefix":"10.1016","volume":"200","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2023.115007_b0005","article-title":"Global and multi-national prevalence of fungal diseases-estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0010","doi-asserted-by":"crossref","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2023.115007_b0015","doi-asserted-by":"crossref","unstructured":"J.R. Perfect, W.E. Dismukes, F. Dromer, D.L. Goldman, J.R. Graybill, R.J. Hamill, T.S. Harrison, R.A. Larsen, O. Lortholary, M.H. Nguyen, P.G. Pappas, W.G. Powderly, N. Singh, J.D. Sobel, T.C. Sorrell, Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America, Clin Infect Dis, 50 (2010) 291-322.","DOI":"10.1086\/649858"},{"key":"10.1016\/j.addr.2023.115007_b0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"Park","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.addr.2023.115007_b0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/21505594.2016.1276692","article-title":"The unmet clinical need of novel antifungal drugs","volume":"8","author":"Krysan","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.addr.2023.115007_b0030","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41579-021-00511-0","article-title":"Treatment strategies for cryptococcal infection: challenges, advances and future outlook","volume":"19","author":"Iyer","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41579-019-0322-2","article-title":"Drug resistance and tolerance in fungi","volume":"18","author":"Berman","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0040","unstructured":"W.H. Organization, WHO fungal priority pathogens list to guide research, development and public health action 2022. https:\/\/www.who.int\/publications\/i\/item\/9789240060241. Accessed 30th March 2023."},{"key":"10.1016\/j.addr.2023.115007_b0045","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1073\/pnas.1117280109","article-title":"Amphotericin primarily kills yeast by simply binding ergosterol","volume":"109","author":"Gray","year":"2012","journal-title":"PNAS"},{"key":"10.1016\/j.addr.2023.115007_b0050","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1289\/ehp.5785","article-title":"Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase","volume":"111","author":"Zarn","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.addr.2023.115007_b0055","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/jphp.12780","article-title":"Echinocandins in antifungal pharmacotherapy","volume":"69","author":"Patil","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115007_b0060","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd.2017.46","article-title":"The antifungal pipeline: a reality check","volume":"16","author":"Perfect","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2023.115007_b0065","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"Fisher","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.addr.2023.115007_b0070","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1146\/annurev-micro-030117-020345","article-title":"Molecular evolution of antifungal drug resistance","volume":"71","author":"Robbins","year":"2017","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0075","doi-asserted-by":"crossref","first-page":"507","DOI":"10.12688\/f1000research.28327.1","article-title":"Novel antifungal agents in clinical trials","volume":"10","author":"Jacobs","year":"2021","journal-title":"F1000Res"},{"key":"10.1016\/j.addr.2023.115007_b0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.drup.2015.10.001","article-title":"Defining the frontiers between antifungal resistance, tolerance and the concept of persistence","volume":"23","author":"Delarze","year":"2015","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.addr.2023.115007_b0085","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.2147\/IJN.S93105","article-title":"Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?","volume":"11","author":"Voltan","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.addr.2023.115007_b0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpharm.2017.03.019","article-title":"Nanoparticles as safe and effective delivery systems of antifungal agents: achievements and challenges","volume":"523","author":"Soliman","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115007_b0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40506-021-00250-z","article-title":"Salvage therapy for the treatment of mucormycosis","volume":"13","author":"Patel","year":"2021","journal-title":"Curr. Treatment Options in Infectious Dis."},{"key":"10.1016\/j.addr.2023.115007_b0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41579-022-00720-1","article-title":"Tackling the emerging threat of antifungal resistance to human health","volume":"20","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0105","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.apsb.2021.04.010","article-title":"Delivery strategies of amphotericin B for invasive fungal infections","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.addr.2023.115007_b0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/jac\/35.1.103","article-title":"Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis","volume":"35","author":"Johnson","year":"1995","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0115","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/jac\/dkl022","article-title":"Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis","volume":"57","author":"Laverdi\u00e8re","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jhin.2016.08.004","article-title":"Multidrug-resistant Candida auris: 'new kid on the block' in hospital-associated infections?","volume":"94","author":"Chowdhary","year":"2016","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.addr.2023.115007_b0125","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/acs.chemrev.0c00199","article-title":"Antifungal drug resistance: molecular mechanisms in Candida albicans and beyond","volume":"121","author":"Lee","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.addr.2023.115007_b0130","series-title":"Principles and procedures for the development of epidemiological cutoff values for antifungal susceptibility testing","author":"Clsi","year":"2016"},{"key":"10.1016\/j.addr.2023.115007_b0135","series-title":"Performance standards for antifungal susceptibility testing of yeasts","author":"Clsi","year":"2022"},{"key":"10.1016\/j.addr.2023.115007_b0140","unstructured":"EUCAST, Clinical breakpoints and dosing of antibiotics, 2023. https:\/\/www.eucast.org\/clinical_breakpoints. 2023. Accessed 30th March 2023."},{"key":"10.1016\/j.addr.2023.115007_b0145","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/mmy\/myab046","article-title":"Antifungal susceptibility testing with YeastONE\u2122 is not predictive of clinical outcomes of Cryptococcus neoformans var. grubii fungemia","volume":"59","author":"Yang","year":"2021","journal-title":"Med. Mycol."},{"key":"10.1016\/j.addr.2023.115007_b0150","doi-asserted-by":"crossref","unstructured":"M.C. Arendrup, T.F. Patterson, Multidrug-resistant Candida: epidemiology, molecular mechanisms, and treatment, J Infect Dis, 216 (2017) S445-s451.","DOI":"10.1093\/infdis\/jix131"},{"key":"10.1016\/j.addr.2023.115007_b0155","doi-asserted-by":"crossref","unstructured":"D.S. Perlin, R. Rautemaa-Richardson, A. Alastruey-Izquierdo, The global problem of antifungal resistance: prevalence, mechanisms, and management, Lancet Infect Dis, 17 (2017) e383-e392.","DOI":"10.1016\/S1473-3099(17)30316-X"},{"key":"10.1016\/j.addr.2023.115007_b0160","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/cid\/cit136","article-title":"Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations","volume":"56","author":"Alexander","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0165","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/myc.12747","article-title":"A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species","volume":"61","author":"Bongomin","year":"2018","journal-title":"Mycoses"},{"key":"10.1016\/j.addr.2023.115007_b0170","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.addr.2023.115007_b0175","doi-asserted-by":"crossref","first-page":"e1008921","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.addr.2023.115007_b0180","first-page":"876","volume":"26","author":"Arensman","year":"2020","journal-title":"Clinical outcomes of patients treated for Candida auris infections in a multisite health system"},{"key":"10.1016\/j.addr.2023.115007_b0185","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/jac\/dkn015","article-title":"Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutations","volume":"61","author":"Xu","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0190","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.medmal.2019.07.014","article-title":"Azole-resistant Aspergillus fumigatus: a global phenomenon originating in the environment?","volume":"50","author":"Jeanvoine","year":"2020","journal-title":"Med. Mal. Infect."},{"key":"10.1016\/j.addr.2023.115007_b0195","first-page":"1","article-title":"Structural and mechanistic insights into fungal \u03b2-1,3-glucan synthase FKS1","author":"Hu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.addr.2023.115007_b0200","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1128\/AAC.48.11.4377-4386.2004","article-title":"Molecular mechanisms of primary resistance to flucytosine in Candida albicans","volume":"48","author":"Hope","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0205","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/AAC.01343-10","article-title":"Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans","volume":"55","author":"Schubert","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0210","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1038\/s41467-021-23745-1","article-title":"Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci","volume":"12","author":"Chang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0215","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1128\/AAC.00605-10","article-title":"Mutational analysis of flucytosine resistance in Candida glabrata","volume":"54","author":"Edlind","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0220","volume":"8","author":"Boyce","year":"2017","journal-title":"Mismatch repair of DNA replication errors contributes to microevolution in the pathogenic fungus Cryptococcus neoformans, mBio"},{"key":"10.1016\/j.addr.2023.115007_b0225","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1038\/ncomms11128","article-title":"Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance","volume":"7","author":"Healey","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145975","article-title":"Transposons: unexpected players in cancer","volume":"808","author":"Pradhan","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.addr.2023.115007_b0235","doi-asserted-by":"crossref","first-page":"9973","DOI":"10.1073\/pnas.2001451117","article-title":"Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro","volume":"117","author":"Gusa","year":"2020","journal-title":"PNAS"},{"key":"10.1016\/j.addr.2023.115007_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.fgb.2019.103253","article-title":"Epigenetic mechanisms of drug resistance in fungi","volume":"132","author":"Chang","year":"2019","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.addr.2023.115007_b0245","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1093\/jac\/dkv070","article-title":"The Rpd3\/Hda1 family of histone deacetylases regulates azole resistance in Candida albicans","volume":"70","author":"Li","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0250","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01344-17","article-title":"Candida albicans Swi\/Snf and mediator complexes differentially regulate Mrr1-induced MDR1 expression and fluconazole resistance","volume":"61","author":"Liu","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0255","first-page":"1001","volume":"7","author":"Law","year":"2017","journal-title":"The Saccharomyces cerevisiae Cdk8 mediator represses AQY1 transcription by inhibiting Set1p-dependent histone methylation, G3"},{"key":"10.1016\/j.addr.2023.115007_b0260","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41564-022-01183-z","article-title":"Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans","volume":"7","author":"Priest","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0265","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45954","article-title":"Genome plasticity in Candida albicans is driven by long repeat sequences","volume":"8","author":"Todd","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.addr.2023.115007_b0270","doi-asserted-by":"crossref","first-page":"e1001653","DOI":"10.1371\/journal.pbio.1001653","article-title":"Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans","volume":"11","author":"Ni","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.addr.2023.115007_b0275","doi-asserted-by":"crossref","DOI":"10.3390\/genes10100787","article-title":"A double-edged sword: aneuploidy is a prevalent strategy in fungal adaptation","volume":"10","author":"Tsai","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0280","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41467-023-36882-6","article-title":"Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance","volume":"14","author":"Arastehfar","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00294-016-0613-3","article-title":"Persistence and drug tolerance in pathogenic yeast","volume":"63","author":"Bojsen","year":"2017","journal-title":"Curr. Genet."},{"key":"10.1016\/j.addr.2023.115007_b0290","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1038\/s41467-018-04926-x","article-title":"Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia","volume":"9","author":"Rosenberg","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0295","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nrmicro.2016.34","article-title":"Distinguishing between resistance, tolerance and persistence to antibiotic treatment","volume":"14","author":"Brauner","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0300","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41579-019-0196-3","article-title":"Definitions and guidelines for research on antibiotic persistence","volume":"17","author":"Balaban","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0305","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/mmy.38.3.201.207","article-title":"Timed-kill curves for Cryptococcus neoformans isolated from patients with AIDS","volume":"38","author":"Rodero","year":"2000","journal-title":"Med. Mycol."},{"key":"10.1016\/j.addr.2023.115007_b0310","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11046-015-9871-8","article-title":"Comparison of different in vitro tests to detect Cryptococcus neoformans not susceptible to amphotericin B","volume":"179","author":"C\u00f3rdoba","year":"2015","journal-title":"Mycopathologia"},{"key":"10.1016\/j.addr.2023.115007_b0315","article-title":"Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and azole tolerance and Cdr1 in azole resistance","volume":"10","author":"Kim","year":"2019","journal-title":"MBio"},{"key":"10.1016\/j.addr.2023.115007_b0320","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1038\/s41598-019-41513-6","article-title":"Gene duplication associated with increased fluconazole tolerance in Candida auris cells of advanced generational age","volume":"9","author":"Bhattacharya","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2023.115007_b0325","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1517\/14656566.9.6.927","article-title":"Fungicidal versus fungistatic: what's in a word?","volume":"9","author":"Lewis","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.addr.2023.115007_b0330","doi-asserted-by":"crossref","first-page":"e51034","DOI":"10.15252\/embr.202051034","article-title":"Antibiotic resistance and persistence-implications for human health and treatment perspectives","volume":"21","author":"Huemer","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.addr.2023.115007_b0335","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-5173(94)90035-3","article-title":"Vehicle effects on in vitro heparin release and skin penetration from different gels","volume":"102","author":"Bonina","year":"1994","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115007_b0340","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.aay3041","article-title":"Effect of tolerance on the evolution of antibiotic resistance under drug combinations","volume":"367","author":"Liu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.addr.2023.115007_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.fgb.2019.103247","article-title":"Antifungal resistance in Aspergillus terreus: a current scenario","volume":"131","author":"Vahedi Shahandashti","year":"2019","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.addr.2023.115007_b0350","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mib.2021.09.017","article-title":"Antibiotic persistence and tolerance: not just one and the same","volume":"64","author":"Ronneau","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0355","doi-asserted-by":"crossref","first-page":"e1000471","DOI":"10.1371\/journal.ppat.1000471","article-title":"Hsp90 orchestrates stress response signaling governing fungal drug resistance","volume":"5","author":"Cowen","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.addr.2023.115007_b0360","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4268","article-title":"Mechanisms of bacterial persistence during stress and antibiotic exposure","volume":"354","author":"Harms","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.addr.2023.115007_b0365","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0002-2016","article-title":"Antifungal drugs: the current armamentarium and development of new agents","volume":"4","author":"Robbins","year":"2016","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.addr.2023.115007_b0370","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00053-16","article-title":"Central role of the trehalose biosynthesis pathway in the pathogenesis of human fungal infections: opportunities and challenges for therapeutic development","volume":"81","author":"Thammahong","year":"2017","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.addr.2023.115007_b0375","article-title":"Platforms for high-throughput screening and force measurements on fungi and oomycetes","volume":"12","author":"Sun","year":"2021","journal-title":"Micromachines (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0380","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2164-12-75","article-title":"Comparative genomics allowed the identification of drug targets against human fungal pathogens","volume":"12","author":"Abadio","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.addr.2023.115007_b0385","volume":"7","author":"Park","year":"2016","journal-title":"Identification of multiple cryptococcal fungicidal drug targets by combined gene dosing and drug affinity responsive target stability screening, mBio"},{"key":"10.1016\/j.addr.2023.115007_b0390","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cels.2015.12.003","article-title":"Prediction of synergism from chemical-genetic interactions by machine learning","volume":"1","author":"Wildenhain","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.addr.2023.115007_b0395","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cell.2008.07.046","article-title":"Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans","volume":"135","author":"Liu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.addr.2023.115007_b0400","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/s41467-020-15329-2","article-title":"Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0405","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1038\/ncomms12766","article-title":"Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0410","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.cell.2014.10.044","article-title":"Unraveling the biology of a fungal meningitis pathogen using chemical genetics","volume":"159","author":"Brown","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.addr.2023.115007_b0415","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2958.2003.03697.x","article-title":"Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery","volume":"50","author":"Roemer","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0420","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1038\/s41467-021-26850-3","article-title":"Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets","volume":"12","author":"Fu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115007_b0425","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.aca.2015.11.023","article-title":"Microfluidics for cell-based high throughput screening platforms - A review","volume":"903","author":"Du","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.addr.2023.115007_b0430","doi-asserted-by":"crossref","first-page":"8087","DOI":"10.1038\/s41598-019-44298-w","article-title":"A novel anti Candida albicans drug screening system based on high-throughput microfluidic chips","volume":"9","author":"Qiang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2023.115007_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/mps2020031","article-title":"High efficiency drug repurposing design for new antifungal agents","volume":"2","author":"Kim","year":"2019","journal-title":"Methods Protoc"},{"key":"10.1016\/j.addr.2023.115007_b0440","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/534314a","article-title":"Can you teach old drugs new tricks?","volume":"534","author":"Nosengo","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.addr.2023.115007_b0445","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fcimb.2019.00049","article-title":"Activity and impact on resistance development of two antivirulence fluoropyrimidine drugs in Pseudomonas aeruginosa","volume":"9","author":"Imperi","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0450","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-0039-3400291","article-title":"Antifungal therapy: new and evolving therapies","volume":"41","author":"Nivoix","year":"2020","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.addr.2023.115007_b0455","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s40265-022-01757-5","article-title":"Treatment of cryptococcal meningitis: how have we got here and where are we going?","volume":"82","author":"Ngan","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.addr.2023.115007_b0460","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/jac\/dkg184","article-title":"Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity","volume":"51","author":"Young","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0465","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1128\/AAC.00212-12","article-title":"The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections","volume":"56","author":"Zhai","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0470","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S1473-3099(19)30127-6","article-title":"Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial","volume":"19","author":"Rhein","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0475","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.drudis.2007.07.016","article-title":"Therapeutic potential of antifungal plant and insect defensins","volume":"12","author":"Thevissen","year":"2007","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2023.115007_b0480","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2174\/1568005043340597","article-title":"IPC synthase as a useful target for antifungal drugs","volume":"4","author":"Sugimoto","year":"2004","journal-title":"Curr. Drug Targets Infect. Disord."},{"key":"10.1016\/j.addr.2023.115007_b0485","first-page":"e00647","volume":"6","author":"Mor","year":"2015","journal-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids, mBio"},{"key":"10.1016\/j.addr.2023.115007_b0490","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.856001","article-title":"Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans","volume":"15","author":"Luberto","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2023.115007_b0495","first-page":"ofaa016","article-title":"Hope on the horizon: novel fungal treatments in development, Open Forum","volume":"7","author":"Rauseo","year":"2020","journal-title":"Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0500","article-title":"Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures","volume":"1866","author":"Kumar","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.addr.2023.115007_b0505","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.7164\/antibiotics.46.1414","article-title":"Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic","volume":"46","author":"Takesako","year":"1993","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.addr.2023.115007_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.128013","article-title":"Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans","volume":"41","author":"Teymuri","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.addr.2023.115007_b0515","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1128\/AAC.00633-08","article-title":"Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A","volume":"53","author":"Aeed","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0520","doi-asserted-by":"crossref","first-page":"359","DOI":"10.7164\/antibiotics.51.359","article-title":"Syntheses of antifungal aureobasidin A analogs with alkyl chains for structure-activity relationship","volume":"51","author":"Kurome","year":"1998","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.addr.2023.115007_b0525","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/acsmedchemlett.5b00029","article-title":"Generation of broad-spectrum antifungal drug candidates from the natural product compound aureobasidin A","volume":"6","author":"Wuts","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.addr.2023.115007_b0530","doi-asserted-by":"crossref","first-page":"e1009699","DOI":"10.1371\/journal.ppat.1009699","article-title":"Aiming for a bull's-eye: targeting antifungals to fungi with dectin-decorated liposomes","volume":"17","author":"Meagher","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.addr.2023.115007_b0535","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2174\/2211738508666200910101923","article-title":"Strategies of drug delivery for deep fungal infection: a review","volume":"8","author":"Ma","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"10.1016\/j.addr.2023.115007_b0540","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0035-2016","article-title":"The fungal cell wall: structure, biosynthesis, and function","volume":"5","author":"Gow","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.addr.2023.115007_b0545","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0966-842X(03)00117-3","article-title":"Antifungal agents: mechanisms of action","volume":"11","author":"Odds","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0550","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/jac\/dkn216","article-title":"Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B","volume":"62","author":"Sandovsky-Losica","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0555","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/lam.13204","article-title":"Synergistic effect of nikkomycin Z with caspofungin and micafungin against Candida albicans and Candida parapsilosis biofilms","volume":"69","author":"Kov\u00e1cs","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0560","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01719-20","article-title":"The future of antifungal drug therapy: novel compounds and targets","volume":"65","author":"Mota Fernandes","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0565","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1093\/infdis\/jiu029","article-title":"Modeling nikkomycin Z dosing and pharmacology in murine pulmonary coccidioidomycosis preparatory to phase 2 clinical trials","volume":"209","author":"Shubitz","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0570","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1128\/AAC.00291-11","article-title":"In vitro activity of E1210, a novel antifungal, against clinically important yeasts and molds","volume":"55","author":"Miyazaki","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0575","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00523-18","article-title":"In vitro and In vivo evaluation of APX001A\/APX001 and other Gwt1 Inhibitors against Cryptococcus","volume":"62","author":"Shaw","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0580","article-title":"Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections","volume":"6","author":"Shaw","year":"2020","journal-title":"J. Fungi (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0585","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/jac\/dku549","article-title":"Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species","volume":"70","author":"Lamoth","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0590","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1128\/JCM.00618-09","article-title":"Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens","volume":"47","author":"Pfaller","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0595","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcp.2016.11.019","article-title":"Antifungals","volume":"133","author":"Campoy","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.addr.2023.115007_b0600","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cell.2020.02.001","article-title":"Targeting strategies for tissue-specific drug delivery","volume":"181","author":"Zhao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.addr.2023.115007_b0605","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.tim.2021.09.007","article-title":"RNA-based therapeutics to treat human fungal infections","volume":"30","author":"Bruch","year":"2022","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0610","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1086\/504492","article-title":"Pharmacology of systemic antifungal agents","volume":"43","author":"Ashley","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0615","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/mmy\/myab042","article-title":"Complexing amphotericin B with gold nanoparticles improves fungal clearance from the brains of mice infected with Cryptococcal neoformans","volume":"59","author":"Chintalacharuvu","year":"2021","journal-title":"Med. Mycol."},{"key":"10.1016\/j.addr.2023.115007_b0620","doi-asserted-by":"crossref","first-page":"10183","DOI":"10.1166\/jnn.2015.11694","article-title":"Bovine serum albumin nanoparticles containing amphotericin B: characterization, cytotoxicity and in vitro antifungal evaluation","volume":"15","author":"Casa","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.addr.2023.115007_b0625","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.addr.2023.115007_b0630","first-page":"358","article-title":"Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes","volume":"10","author":"Gupta","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115007_b0635","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3109\/10717544.2013.843610","article-title":"Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations","volume":"21","author":"El-Badry","year":"2014","journal-title":"Drug Deliv."},{"issue":"Suppl 4","key":"10.1016\/j.addr.2023.115007_b0640","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0507.2008.01606.x","article-title":"Epidemiological trends in skin mycoses worldwide","volume":"51","author":"Havlickova","year":"2008","journal-title":"Mycoses"},{"key":"10.1016\/j.addr.2023.115007_b0645","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4155\/tde-2016-0090","article-title":"High failure rate of transungal drug delivery: need for new strategies","volume":"8","author":"Tiwary","year":"2017","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2023.115007_b0650","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11046-016-0045-0","article-title":"New antifungal agents and new formulations against dermatophytes","volume":"182","author":"Gupta","year":"2017","journal-title":"Mycopathologia"},{"key":"10.1016\/j.addr.2023.115007_b0655","article-title":"SLN- and NLC-encapsulating antifungal agents: skin drug delivery and their unexplored potential for treating onychomycosis","author":"Gratieri","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.addr.2023.115007_b0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122122","article-title":"Gold nanoparticles for skin drug delivery","volume":"625","author":"Chen","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115007_b0665","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.colsurfb.2010.12.014","article-title":"Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids","volume":"83","author":"Xie","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2023.115007_b0670","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ejpb.2011.11.002","article-title":"Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA","volume":"80","author":"Yu","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115007_b0675","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1208\/s12249-009-9199-0","article-title":"Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery","volume":"10","author":"Bhalekar","year":"2009","journal-title":"AAPS PharmSciTech."},{"key":"10.1016\/j.addr.2023.115007_b0680","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.colsurfb.2016.03.013","article-title":"Time to overcome fluconazole resistant Candida isolates: solid lipid nanoparticles as a novel antifungal drug delivery system","volume":"142","author":"Moazeni","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2023.115007_b0685","doi-asserted-by":"crossref","first-page":"14566","DOI":"10.1038\/s41598-021-94012-y","article-title":"Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents","volume":"11","author":"Mussin","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2023.115007_b0690","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.addr.2023.115007_b0695","doi-asserted-by":"crossref","DOI":"10.3390\/ph13090248","article-title":"Current insights on antifungal therapy: novel nanotechnology approaches for drug delivery systems and new drugs from natural sources","volume":"13","author":"Sousa","year":"2020","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0700","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1007\/s00253-021-11296-w","article-title":"Antifungal activity of silver nanoparticles synthesized by iturin against Candida albicans in vitro and in vivo","volume":"105","author":"Zhou","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.addr.2023.115007_b0705","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12951-015-0147-8","article-title":"Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study","volume":"13","author":"Lara","year":"2015","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.addr.2023.115007_b0710","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and dysfunction of the blood-brain barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.addr.2023.115007_b0715","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1039\/C6CS00076B","article-title":"Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery","volume":"45","author":"Oller-Salvia","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.addr.2023.115007_b0720","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/mmy\/myx054","article-title":"Relationship between intracranial pressure and antifungal agents levels in the CSF of patients with cryptococcal meningitis","volume":"56","author":"Wirth","year":"2018","journal-title":"Med. Mycol."},{"key":"10.1016\/j.addr.2023.115007_b0725","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/10717544.2017.1346002","article-title":"Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood-brain barrier permeability","volume":"24","author":"Zhang","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2023.115007_b0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.119002","article-title":"Borneol and poly (ethylene glycol) dual modified BSA nanoparticles as an itraconazole vehicle for brain targeting","volume":"575","author":"Zhang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115007_b0735","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1163\/092050609X12457418779185","article-title":"Preparation and therapeutic efficacy of polysorbate-80-coated amphotericin B\/PLA-b-PEG nanoparticles","volume":"20","author":"Ren","year":"2009","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.addr.2023.115007_b0740","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/1061186X.2010.492523","article-title":"Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles","volume":"19","author":"Chen","year":"2011","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2023.115007_b0745","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3389\/fimmu.2018.01261","article-title":"The interaction of human pathogenic fungi with C-type lectin receptors","volume":"9","author":"Goyal","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2023.115007_b0750","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40694-021-00126-3","article-title":"DC-SIGN targets amphotericin B-loaded liposomes to diverse pathogenic fungi","volume":"8","author":"Ambati","year":"2021","journal-title":"Fungal Biol. Biotechnol."},{"key":"10.1016\/j.addr.2023.115007_b0755","doi-asserted-by":"crossref","unstructured":"S. Ambati, E.C. Ellis, T. Pham, Z.A. Lewis, X. Lin, R.B. Meagher, Antifungal liposomes directed by dectin-2 offer a promising therapeutic option for pulmonary aspergillosis, mBio, 12 (2021).","DOI":"10.1128\/mBio.00030-21"},{"key":"10.1016\/j.addr.2023.115007_b0760","doi-asserted-by":"crossref","unstructured":"S. Ambati, A.R. Ferarro, S.E. Kang, J. Lin, X. Lin, M. Momany, Z.A. Lewis, R.B. Meagher, Dectin-1-targeted antifungal liposomes exhibit enhanced efficacy, mSphere, 4 (2019).","DOI":"10.1128\/mSphere.00121-19"},{"key":"10.1016\/j.addr.2023.115007_b0765","doi-asserted-by":"crossref","first-page":"e0146721","DOI":"10.1128\/AAC.01467-21","article-title":"DectiSomes: glycan targeting of liposomal drugs improves the treatment of disseminated candidiasis","volume":"66","author":"Ambati","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2023.115007_b0770","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/EC.00399-06","article-title":"Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans","volume":"6","author":"Baker","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.addr.2023.115007_b0775","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-407677-8.00002-6","article-title":"Fungal cell wall organization and biosynthesis","volume":"81","author":"Free","year":"2013","journal-title":"Adv. Genet."},{"key":"10.1016\/j.addr.2023.115007_b0780","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1039\/D2BM01263D","article-title":"Calcofluor white-cholesteryl hydrogen succinate conjugate mediated liposomes for enhanced targeted delivery of voriconazole into Candida albicans","volume":"11","author":"Liu","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.addr.2023.115007_b0785","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1021\/acs.nanolett.8b02229","article-title":"Nanoparticles targeted against cryptococcal pneumonia by interactions between chitosan and its peptide ligand","volume":"18","author":"Tang","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2023.115007_b0790","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau5480","article-title":"Antimicrobial peptides: application informed by evolution","volume":"368","author":"Lazzaro","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.addr.2023.115007_b0795","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tifs.2021.01.005","article-title":"The structure-mechanism relationship and mode of actions of antimicrobial peptides: a review","volume":"109","author":"Li","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.addr.2023.115007_b0800","doi-asserted-by":"crossref","first-page":"2111344","DOI":"10.1002\/adfm.202111344","article-title":"Augmenting the precise targeting of antimicrobial peptides (AMPs) and AMP-based drug delivery via affinity-filtering strategy","volume":"32","author":"Tang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.addr.2023.115007_b0805","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1002\/med.21879","article-title":"Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug-resistant infections","volume":"42","author":"Zhu","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.addr.2023.115007_b0810","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415882","article-title":"Antimicrobial peptide octominin-encapsulated chitosan nanoparticles enhanced antifungal and antibacterial activities","volume":"23","author":"Jayathilaka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.addr.2023.115007_b0815","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019695","article-title":"Metabolism in fungal pathogenesis","volume":"4","author":"Ene","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.addr.2023.115007_b0820","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/mmi.13887","article-title":"Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi","volume":"107","author":"Ries","year":"2018","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0825","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0928-8244(03)00301-8","article-title":"Iron gathering by zoopathogenic fungi","volume":"40","author":"Howard","year":"2004","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.addr.2023.115007_b0830","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3201\/eid0503.990305","article-title":"Iron loading and disease surveillance","volume":"5","author":"Weinberg","year":"1999","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.addr.2023.115007_b0835","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1021\/acsnano.8b09681","article-title":"Oriented assembly of cell-mimicking nanoparticles via a molecular affinity strategy for targeted drug delivery","volume":"13","author":"Xie","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2023.115007_b0840","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes","volume":"99","author":"Wishart","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2023.115007_b0845","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.FUNK-0014-2016","article-title":"Fungi that infect humans","volume":"5","author":"K\u00f6hler","year":"2017","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.addr.2023.115007_b0850","article-title":"New Applications of photodynamic therapy in the management of candidiasis","volume":"7","author":"Rodr\u00edguez-Cerdeira","year":"2021","journal-title":"J. Fungi. (Basel)"},{"key":"10.1016\/j.addr.2023.115007_b0855","doi-asserted-by":"crossref","first-page":"15145","DOI":"10.1039\/C9CC08463K","article-title":"A lipase-responsive antifungal nanoplatform for synergistic photodynamic\/photothermal\/pharmaco-therapy of azole-resistant Candida albicans infections","volume":"55","author":"Yang","year":"2019","journal-title":"Chem. Commun. (Camb)"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X23003228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X23003228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:38:10Z","timestamp":1759210690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X23003228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":171,"alternative-id":["S0169409X23003228"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2023.115007","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Confronting antifungal resistance, tolerance, and persistence: Advances in drug target discovery and delivery systems","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2023.115007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115007"}}