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Channappa, Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays, ACS Chem Neurosci, 13 (2022) 1433-1445.","DOI":"10.1021\/acschemneuro.2c00076"},{"key":"10.1016\/j.addr.2023.115025_b0460","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/embor.2013.168","article-title":"Loss of iron triggers PINK1\/Parkin-independent mitophagy","volume":"14","author":"Allen","year":"2013","journal-title":"EMBO Rep"},{"key":"10.1016\/j.addr.2023.115025_b0465","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.2174\/138161210793292519","article-title":"Mitochondria-Targeted Antioxidant Peptides","volume":"16","author":"Rocha","year":"2010","journal-title":"Curr Pharm Design"},{"key":"10.1016\/j.addr.2023.115025_b0470","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2003266","article-title":"A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways","volume":"6","author":"Chae","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.addr.2023.115025_b0475","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1471-4159.2006.04018.x","article-title":"Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis","volume":"98","author":"Petri","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.addr.2023.115025_b0480","first-page":"2029","article-title":"First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics, Brit","volume":"171","author":"Szeto","year":"2014","journal-title":"J Pharmacol"},{"key":"10.1016\/j.addr.2023.115025_b0485","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","article-title":"Mitochondrial dynamics in neurodegeneration","volume":"23","author":"Itoh","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.addr.2023.115025_b0490","doi-asserted-by":"crossref","first-page":"14151","DOI":"10.1073\/pnas.1111314108","article-title":"The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections","volume":"108","author":"Kornmann","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.addr.2023.115025_b0495","volume":"4","author":"Manor","year":"2015","journal-title":"A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division, eLife"},{"key":"10.1016\/j.addr.2023.115025_b0500","doi-asserted-by":"crossref","unstructured":"S.C. 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Biol. Chem."},{"key":"10.1016\/j.addr.2023.115025_b0550","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1038\/ncomms4996","article-title":"ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS\/FTD-associated TDP-43","volume":"5","author":"Stoica","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2023.115025_b0555","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. 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Alzheimer's Disease Cooperative Study, Safety and efficacy of Edonerpic maleate for patients with mild to moderate Alzheimer disease: a phase 2 randomized clinical trial, JAMA Neurol., 76 (2019) 1330-1339.","DOI":"10.1001\/jamaneurol.2019.1868"},{"key":"10.1016\/j.addr.2023.115025_b0840","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/jm3007323","article-title":"Synthesis and biological evaluation of the 1-arylpyrazole class of sigma(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)","volume":"55","author":"Diaz","year":"2012","journal-title":"J. Med. 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