{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:35:23Z","timestamp":1792607723450,"version":"4.5.0"},"reference-count":378,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.addr.2023.115086","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T20:53:41Z","timestamp":1695243221000},"page":"115086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["Safety of surfactant excipients in oral drug formulations"],"prefix":"10.1016","volume":"202","author":[{"given":"Sam","family":"Maher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Geoghegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Brayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2023.115086_b0005","first-page":"279","article-title":"Is chronic detergent ingestion harmful to the gut?","volume":"41","author":"Mercurius-Taylor","year":"1984","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.addr.2023.115086_b0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5173(98)00345-7","article-title":"Surfactants in membrane solubilisation","volume":"177","author":"Jones","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-4157(75)90016-7","article-title":"Solubilization of membranes by detergents","volume":"415","author":"Helenius","year":"1975","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes"},{"key":"10.1016\/j.addr.2023.115086_b0020","first-page":"285","article-title":"Solubilization of phospholipids by detergents structural and kinetic aspects, biochimica et biophysica acta (BBA) - reviews on","volume":"737","author":"Lichtenberg","year":"1983","journal-title":"Biomembranes"},{"key":"10.1016\/j.addr.2023.115086_b0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.addr.2016.06.005","article-title":"Intestinal permeation enhancers for oral peptide delivery","volume":"106","author":"Maher","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2023.115086_b0030","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.autrev.2015.01.009","article-title":"Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease","volume":"14","author":"Lerner","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.addr.2023.115086_b0035","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fimmu.2017.00598","article-title":"Leaky gut as a danger signal for autoimmune diseases","volume":"8","author":"Mu","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2023.115086_b0040","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/ecco-jcc\/jjaa254","article-title":"Food additive emulsifiers and their impact on gut microbiome, permeability, and inflammation: mechanistic insights in inflammatory bowel disease","volume":"15","author":"Bancil","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.addr.2023.115086_b0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1158\/0008-5472.CAN-16-1359","article-title":"Dietary emulsifier-induced low-grade inflammation promotes colon carcinogenesis","volume":"77","author":"Viennois","year":"2017","journal-title":"Can. Res."},{"key":"10.1016\/j.addr.2023.115086_b0050","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.mehy.2011.01.030","article-title":"Synthetic surfactant food additives can cause intestinal barrier dysfunction","volume":"76","author":"Cs\u00e1ki","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.addr.2023.115086_b0055","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.mehy.2003.10.037","article-title":"Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?","volume":"63","author":"Ilback","year":"2004","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.addr.2023.115086_b0060","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/BF02915334","article-title":"A classification of biologic lipids based upon their interaction in aqueous systems","volume":"45","author":"Small","year":"1968","journal-title":"J. Am. Oil Chem. Soc."},{"key":"10.1016\/j.addr.2023.115086_b0065","first-page":"311","article-title":"Classification of surface-active agents by\u201c HLB\u201d","volume":"1","author":"Griffin","year":"1949","journal-title":"J. Soc. Cosmet. Chem."},{"key":"10.1016\/j.addr.2023.115086_b0070","unstructured":"T. Hargreaves, Surfactants in Action, in: T. Hargreaves (Ed.) In: Chemical Formulation: An Overview of Surfactant Based Chemical Preparations Used in Everyday Life, The Royal Society of Chemistry 2003, pp. P007-P012."},{"key":"10.1016\/j.addr.2023.115086_b0075","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s12325-018-0707-z","article-title":"Safety of polysorbate 80 in the oncology setting","volume":"35","author":"Schwartzberg","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.addr.2023.115086_b0080","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0149-2918(99)80053-8","article-title":"Adverse effects of benzalkonium chloride on the nasal mucosa: allergic rhinitis and rhinitis medicamentosa","volume":"21","author":"Graf","year":"1999","journal-title":"Clin. Ther."},{"key":"10.1016\/j.addr.2023.115086_b0085","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1365-2133.2010.09954.x","article-title":"Effect of aqueous cream BP on human stratum corneum in vivo","volume":"163","author":"Tsang","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.addr.2023.115086_b0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-4157(75)90016-7","article-title":"Solubilization of membranes by detergents","volume":"415","author":"Helenius","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2023.115086_b0095","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/mp500776a","article-title":"interaction with mixed micelles in the intestine attenuates the permeation enhancing potential of alkyl-maltosides","volume":"12","author":"Gradauer","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0100","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1016\/j.chroma.2009.09.026","article-title":"Rapid determination of surfactant critical micelle concentrations using pressure-driven flow with capillary electrophoresis instrumentation","volume":"1216","author":"Stanley","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.addr.2023.115086_b0105","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1271\/bbb.65.743","article-title":"Effects of medium-chain fatty acids on intracellular calcium levels and the cytoskeleton in human intestinal (Caco-2) cell monolayers","volume":"65","author":"Kimura","year":"2001","journal-title":"Biosci. Biotech. Bioch."},{"key":"10.1016\/j.addr.2023.115086_b0110","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0022-3565(25)12150-2","article-title":"Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers","volume":"275","author":"Lindmark","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2023.115086_b0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1208\/s12249-022-02211-1","article-title":"Non-ionic surfactants as a p-Glycoprotein(P-gp) efflux inhibitor for optimal drug delivery\u2014a concise outlook","volume":"23","author":"Rathod","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2023.115086_b0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/1756283X14550134","article-title":"New insights and challenges in microscopic colitis","volume":"8","author":"Ohlsson","year":"2015","journal-title":"Therap. Adv. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b0125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s11095-020-02963-0","article-title":"absorption-Enhancing mechanisms of capryol 90, a novel absorption enhancer, for improving the intestinal absorption of poorly absorbed drugs: contributions to trans- or Para-Cellular pathways","volume":"37","author":"Ukai","year":"2020","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0130","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/jps.2600810908","article-title":"epithelial transport of drugs in cell culture. VII: Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells","volume":"81","author":"Anderberg","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0135","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/jps.2600820412","article-title":"epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells","volume":"82","author":"Anderberg","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11095-007-9509-8","article-title":"Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer","volume":"25","author":"Narkar","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0145","first-page":"6","article-title":"Physicochemical properties of solutol HS 15 and its solubisates","volume":"1","author":"Ruchatz","year":"1998","journal-title":"BASF ExAct"},{"key":"10.1016\/j.addr.2023.115086_b0150","series-title":"Handbook of pharmaceutical excipients","author":"Rowe","year":"2009"},{"key":"10.1016\/j.addr.2023.115086_b0155","article-title":"Kolliphor\u00ae HS 15 - an enabler for parenteral and oral formulations","volume":"22","author":"Ali","year":"2019","journal-title":"Am. Pharm. Rev."},{"key":"10.1016\/j.addr.2023.115086_b0160","first-page":"G384","article-title":"Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion","volume":"261","author":"Kvietys","year":"1991","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jconrel.2019.08.008","article-title":"Labrasol\u00ae is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo rat studies","volume":"310","author":"McCartney","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b0170","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.chroma.2010.09.057","article-title":"Mixed-mode and reversed-phase liquid chromatography-tandem mass spectrometry methodologies to study composition and base hydrolysis of polysorbate 20 and 80","volume":"1218","author":"Hewitt","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.addr.2023.115086_b0175","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/jps.21190","article-title":"Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways","volume":"97","author":"Kerwin","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0180","unstructured":"Committee for Medicinal Products for Human Use (2018) Information for the package leaflet regarding polysorbates used as excipients in medicinal products for human use, European Medicines Agency, EMA\/CHMP\/190743\/2106."},{"key":"10.1016\/j.addr.2023.115086_b0185","unstructured":"Food And Drug Administration Inactive Ingredients database for approved drug products www.fda.gov\/Drugs\/InformationOnDrugs\/ucm113978.htm."},{"key":"10.1016\/j.addr.2023.115086_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2736(78)90368-1","article-title":"Action of surface-active substances on biological membranes. II. Hemolytic activity of nonionic surfactants, biochimica et biophysica Acta (BBA) -","volume":"507","author":"Zaslavsky","year":"1978","journal-title":"Biomembranes"},{"key":"10.1016\/j.addr.2023.115086_b0195","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1080\/17425247.2021.1942838","article-title":"Transient permeation enhancer\u00ae (TPE\u00ae) technology for oral delivery of octreotide: a technological evaluation","volume":"18","author":"Brayden","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2023.115086_b0200","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1023\/A:1016033702220","article-title":"the use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system","volume":"13","author":"Nerurkar","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0168-3659(03)00163-9","article-title":"Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines","volume":"90","author":"Lo","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1211\/0022357001773805","article-title":"Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells","volume":"52","author":"Dimitrijevic","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0215","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1248\/cpb.31.3255","article-title":"effect of pharmaceutical adjuvants on the rectal permeability of drugs. II. Effect of tween-type surfactants on the permeability of drugs in the rat rectum","volume":"31","author":"Nakanishi","year":"1983","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.addr.2023.115086_b0220","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jps.2600750414","article-title":"Contribution of calcium ion sequestration by polyoxyethylated nonionic surfactants to the enhanced colonic absorption of p-aminobenzoic acid","volume":"75","author":"Sakai","year":"1986","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0225","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1248\/bpb1978.8.661","article-title":"Effect of synthetic surfactants on drug absorption in the presence of a physiologic surfactant, sodium taurocholate, in rats","volume":"8","author":"Kimura","year":"1985","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2023.115086_b0230","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/0278-6915(84)90165-0","article-title":"Influence of surface-active food additives on the integrity and permeability of rat intestinal mucosa","volume":"22","author":"Tagesson","year":"1984","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.addr.2023.115086_b0235","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/1056-8719(94)00060-H","article-title":"Evaluation of mucosal damage of surfactants in rat jejunum and colon","volume":"33","author":"Oberle","year":"1995","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.addr.2023.115086_b0240","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0014-827X(98)00081-0","article-title":"Phospholipid-detergent systems: effects of polysorbates on the release of liposomal caffeine","volume":"53","author":"Fadda","year":"1998","journal-title":"Il Farmaco"},{"key":"10.1016\/j.addr.2023.115086_b0245","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejps.2005.07.002","article-title":"Permeabilisation and solubilisation of soybean phosphatidylcholine bilayer vesicles, as membrane models, by polysorbate, tween 80","volume":"26","author":"Sim\u00f5es","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0250","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1016\/S0021-9258(17)42842-0","article-title":"Detergent-induced solubilization of cytochrome c oxidase as detected in a novel reconstituted system","volume":"259","author":"Madden","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2023.115086_b0255","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1248\/cpb.33.3527","article-title":"Assessment of pharmaceutical excipient-induced gastrointestinal mucosal damage in rats in vivo by measuring the permeation of phenolsulfonphthalein","volume":"33","author":"Nakamura","year":"1985","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.addr.2023.115086_b0260","doi-asserted-by":"crossref","unstructured":"E.P.o.F. Additives, N.S.a.t. Food, Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives, EFSA Journal, 13 (2015) 4152.","DOI":"10.2903\/j.efsa.2015.4152"},{"key":"10.1016\/j.addr.2023.115086_b0265","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/toxsci\/kfq207","article-title":"Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies","volume":"117","author":"Thackaberry","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0270","unstructured":"NTP Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344\/N Rats and B6C3F1 Mice (Feed Studies), Natl Toxicol Program Tech Rep Ser, 415 (1992) 1-225."},{"key":"10.1016\/j.addr.2023.115086_b0275","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/jn\/60.3.367","article-title":"Nutritional studies on rats on diets containing high levels of partial ester emulsifiers: I. General plan and procedures; growth and food utilization","volume":"60","author":"Oser","year":"1956","journal-title":"J. Nutr."},{"key":"10.1016\/j.addr.2023.115086_b0280","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/toxsci\/kfu055","article-title":"Food emulsifier polysorbate 80 increases intestinal absorption of Di-(2-Ethylhexyl) phthalate in rats","volume":"139","author":"Lu","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115411","article-title":"Food emulsifier polysorbate 80 promotes the intestinal absorption of mono-2-ethylhexyl phthalate by disturbing intestinal barrier","volume":"414","author":"Zhu","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0290","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ejpb.2014.10.008","article-title":"A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells","volume":"88","author":"Brayden","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115086_b0295","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2018.02.202","article-title":"Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats","volume":"498","author":"Suyama","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.addr.2023.115086_b0300","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1136\/gut.2009.195370","article-title":"Translocation of crohn's disease escherichia coli across m-cells: contrasting effects of soluble plant fibres and emulsifiers","volume":"59","author":"Roberts","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b0305","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature14232","article-title":"Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome","volume":"519","author":"Chassaing","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.addr.2023.115086_b0310","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.3390\/nu12092827","article-title":"emulsifiers impact colonic length in mice and emulsifier restriction is feasible in people with crohn\u2019s disease","volume":"12","author":"Sandall","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2023.115086_b0315","doi-asserted-by":"crossref","first-page":"e14629","DOI":"10.14814\/phy2.14629","article-title":"Polysorbate 80-induced leaky gut impairs skeletal muscle metabolism in mice","volume":"8","author":"Nishimura","year":"2020","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.addr.2023.115086_b0320","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/gutjnl-2016-313099","article-title":"Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation","volume":"66","author":"Chassaing","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b0325","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.3389\/fmicb.2016.01878","article-title":"Effects of tween 80 on growth and biofilm formation in laboratory media","volume":"7","author":"Nielsen","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2023.115086_b0330","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1471-2180-12-217","article-title":"Polysorbate 80 and helicobacter pylori: a microbiological and ultrastructural study","volume":"12","author":"Figura","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.addr.2023.115086_b0335","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/19440049.2017.1311420","article-title":"Dietary exposures for the safety assessment of seven emulsifiers commonly added to foods in the united states and implications for safety","volume":"34","author":"Shah","year":"2017","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"10.1016\/j.addr.2023.115086_b0340","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/nbu.12408","article-title":"Food additives: Assessing the impact of exposure to permitted emulsifiers on bowel and metabolic health \u2013 introducing the FADiets study","volume":"44","author":"Partridge","year":"2019","journal-title":"Nutr. Bull."},{"key":"10.1016\/j.addr.2023.115086_b0345","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1038\/s41598-018-27957-2","article-title":"Acute exposure to commonly ingested emulsifiers alters intestinal mucus structure and transport properties","volume":"8","author":"Lock","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2023.115086_b0350","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1021\/la701081s","article-title":"Transport properties and aggregation phenomena of polyoxyethylene sorbitane monooleate (polysorbate 80) in pig gastrointestinal mucin and mucus","volume":"23","author":"Lafitte","year":"2007","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2023.115086_b0355","doi-asserted-by":"crossref","unstructured":"S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.-Y. Wang, R. Cone, J. Hanes, Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus, Proceedings of the National Academy of Sciences, 104 (2007) 1482-1487.","DOI":"10.1073\/pnas.0608611104"},{"key":"10.1016\/j.addr.2023.115086_b0360","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF02886387","article-title":"The effect of feeding large amounts of emulsifiers polyoxyethylene (20) sorbitan monostearate (tween 60) and sorbitan monostearate (span 60) to humans","volume":"21","author":"Waldstein","year":"1954","journal-title":"Am. J. Dig. Dis."},{"key":"10.1016\/j.addr.2023.115086_b0365","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejpb.2019.07.013","article-title":"intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations","volume":"142","author":"Dahlgren","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115086_b0370","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s11095-022-03312-z","article-title":"Lack of an effect of polysorbate 80 on intestinal drug permeability in humans","volume":"39","author":"Metry","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0375","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0380","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s40268-014-0041-0","article-title":"Differential effects of commercial-grade and purified poloxamer 188 on renal function","volume":"14","author":"Emanuele","year":"2014","journal-title":"Drugs R D"},{"key":"10.1016\/j.addr.2023.115086_b0385","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000208160","article-title":"Desaggregation of human red blood cells by various surface-active agents as related to changes of cell shape and hemolysis","volume":"53","author":"Gaehtgens","year":"1975","journal-title":"Acta Haematol."},{"key":"10.1016\/j.addr.2023.115086_b0390","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejpb.2011.04.010","article-title":"Effect of the non-ionic surfactant poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers","volume":"79","author":"Fischer","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115086_b0395","first-page":"200","article-title":"Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications, recent pat","volume":"6","author":"Moloughney","year":"2012","journal-title":"Biotechnol"},{"key":"10.1016\/j.addr.2023.115086_b0400","doi-asserted-by":"crossref","unstructured":"V.A. Feitosa, V.C.d. Almeida, B. Malheiros, R.D.d. Castro, L.R.S. Barbosa, N.N.P. Cerize, C.d.O. Rangel-Yagui, Polymeric micelles of pluronic F127 reduce hemolytic potential of amphiphilic drugs, Colloids and Surfaces B: Biointerfaces, 180 (2019) 177-185.","DOI":"10.1016\/j.colsurfb.2019.04.045"},{"key":"10.1016\/j.addr.2023.115086_b0405","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.2042-7158.1981.tb13759.x","article-title":"Non-ionic surfactants and gastric mucosal transport of paraquat","volume":"33","author":"Walters","year":"1981","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0410","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1208\/s12249-021-02019-5","article-title":"Formulation of gelucire\u00ae-based solid dispersions of atorvastatin calcium: in vitrodissolution and in vivo bioavailability study","volume":"22","author":"Aldosari","year":"2021","journal-title":", AAPS PharmSciTech"},{"issue":"Suppl 1","key":"10.1016\/j.addr.2023.115086_b0415","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.jdent.2018.11.005","article-title":"A randomised clinical study comparing the effect of steareth 30 and SLS containing toothpastes on oral epithelial integrity (desquamation)","volume":"80","author":"Green","year":"2019","journal-title":"J. Dent."},{"key":"10.1016\/j.addr.2023.115086_b0420","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/0748233793009001-210","article-title":"Oil-Soluble antioxidants in foods","volume":"9","author":"Papas","year":"1993","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.addr.2023.115086_b0425","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1208\/s12248-016-9996-9","article-title":"Development of a Non-Aqueous dispersion to improve intestinal epithelial flux of poorly permeable macromolecules","volume":"19","author":"Maher","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2023.115086_b0430","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3390\/pharmaceutics12050462","article-title":"Enhanced intestinal absorption of insulin by capryol 90, a novel absorption enhancer in rats: Implications in oral insulin delivery","volume":"12","author":"Ukai","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b0435","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/10915818809023137","article-title":"Final report on the safety assessment of cetearyl alcohol, cetyl alcohol, isostearyl alcohol, myristyl alcohol, and behenyl alcohol","volume":"7","author":"Elder","year":"1988","journal-title":"J. Am. Coll. Toxicol."},{"key":"10.1016\/j.addr.2023.115086_b0440","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.ecoenv.2008.07.012","article-title":"Human health risk assessment of long chain alcohols","volume":"72","author":"Veenstra","year":"2009","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.addr.2023.115086_b0445","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.2042-7158.1987.tb03123.x","article-title":"Effect of triglyceride on small intestinal absorption of cefoxitin in rats","volume":"39","author":"Yoshitomi","year":"1987","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0450","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.3748\/wjg.v18.i29.3814","article-title":"Impact of environmental and dietary factors on the course of inflammatory bowel disease","volume":"18","author":"Cabr\u00e9","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b0455","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","article-title":"Dietary lipids, gut microbiota and lipid metabolism","volume":"20","author":"Schoeler","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.addr.2023.115086_b0460","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jps.2600771007","article-title":"Absorption enhancement of rectally infused cefoxitin by medium chain monoglycerides in conscious rats","volume":"77","author":"Watanabe","year":"1988","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0465","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1248\/bpb1978.7.856","article-title":"Improvement of bioavailability of poorly absorbed drugs. I. Effect of medium chain glyceride base on the rectal absorption of cefmetazole sodium in rats","volume":"7","author":"Sekine","year":"1984","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2023.115086_b0470","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1248\/bpb1978.13.591","article-title":"Duration of absorption-enhancing effect of sodium octanoate, sodium hexanoate or glyceryl-1-monooctanoate on rectal absorption of gentamicin in rabbits","volume":"13","author":"Matsumoto","year":"1990","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.addr.2023.115086_b0475","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/ijms19041114","article-title":"Antibacterial free fatty acids and monoglycerides: biological activities, experimental testing, and therapeutic applications","volume":"19","author":"Yoon","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0480","article-title":"Glycerol monocaprylate modulates gut microbiota and increases Short-Chain fatty acids production without adverse effects on metabolism and inflammation","volume":"13","author":"Zhang","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2023.115086_b0485","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700547","article-title":"Antimicrobial Emulsifier-Glycerol monolaurate induces metabolic syndrome, gut microbiota dysbiosis, and systemic Low-Grade inflammation in Low-Fat diet fed mice","volume":"62","author":"Jiang","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.addr.2023.115086_b0490","doi-asserted-by":"crossref","first-page":"e1801417","DOI":"10.1002\/mnfr.201801417","article-title":"Glycerol-Monolaurate-Mediated attenuation of metabolic syndrome is associated with the modulation of gut microbiota in High-Fat-Diet-Fed mice","volume":"63","author":"Zhao","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.addr.2023.115086_b0495","doi-asserted-by":"crossref","DOI":"10.3390\/nu11091981","article-title":"High-dose glycerol monolaurate Up-Regulated beneficial indigenous microbiota without inducing metabolic dysfunction and systemic inflammation: New insights into its antimicrobial potential","volume":"11","author":"Mo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2023.115086_b0500","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00190-20","article-title":"Modulation of the gut microbiota during High-Dose glycerol Monolaurate-Mediated amelioration of obesity in mice fed a High-Fat diet","volume":"11","author":"Zhao","year":"2020","journal-title":"MBio"},{"key":"10.1016\/j.addr.2023.115086_b0505","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijpharm.2018.01.008","article-title":"Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae","volume":"539","author":"Maher","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0510","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ejps.2012.07.005","article-title":"Evaluation of cytotoxicity of surfactants used in self-micro emulsifying drug delivery systems and their effects on paracellular transport in Caco-2 cell monolayer","volume":"47","author":"Ujhelyi","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0515","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ejps.2005.01.001","article-title":"Effect of self-microemulsifying drug delivery systems containing labrasol on tight junctions in Caco-2 cells","volume":"24","author":"Sha","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0520","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jpba.2005.06.013","article-title":"in vitro studies of the hemolytic activity of microemulsions in human erythrocytes","volume":"39","author":"Aparicio","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.addr.2023.115086_b0525","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/10915810600961531","article-title":"Nonclinical vehicle use in studies by multiple routes in multiple species","volume":"25","author":"Gad","year":"2006","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.addr.2023.115086_b0530","doi-asserted-by":"crossref","first-page":"S266","DOI":"10.1016\/j.toxlet.2010.03.886","article-title":"toxic effects associated to the use of the delivery enhancer caprylocaproyl macrogol-8 glyceride (labrasol) in early toxicological studies in rats An activity of the Melius project","volume":"196","author":"Saavedra","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.addr.2023.115086_b0535","series-title":"Biological implications of surfactant presence in formulations, Surfactant systems: Their chemistry, pharmacy and biology","first-page":"388","author":"Attwood","year":"1983"},{"key":"10.1016\/j.addr.2023.115086_b0540","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1248\/bpb.27.418","article-title":"Studies on the intestinal absorption of low molecular weight heparin using saturated fatty acids and their derivatives as an absorption enhancer in rats","volume":"27","author":"Mori","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.addr.2023.115086_b0545","first-page":"319","article-title":"Lipid excipients peceol and gelucire 44\/14 decrease p-glycoprotein mediated efflux of rhodamine 123 partially due to modifying p-glycoprotein protein expression within Caco-2 cells","volume":"10","author":"Sachs-Barrable","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0550","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/jps.23458","article-title":"Kinetic analysis of the toxicity of pharmaceutical excipients cremophor EL and RH40 on endothelial and epithelial cells","volume":"102","author":"Kiss","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0555","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejps.2016.06.011","article-title":"Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system with Caco-2 cell model: cremophor EL as the surfactant","volume":"91","author":"Bu","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0560","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11095-017-2327-8","article-title":"Caco-2 cell conditions enabling studies of drug absorption from digestible Lipid-Based formulations","volume":"35","author":"Keemink","year":"2018","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0565","unstructured":"Committee for Veterinary Medicinal Products (1999) Polyoxyl castor oil Summary Report, European Medicines Agency, EMEA\/MRL\/614\/99."},{"key":"10.1016\/j.addr.2023.115086_b0570","doi-asserted-by":"crossref","unstructured":"1 Final Report on the Safety Assessment of Polysorbates 20, 21, 40, 60, 61, 65, 80, 81, and 85, Journal of the American College of Toxicology, 3 (1984) 1-82.","DOI":"10.3109\/10915818409021272"},{"key":"10.1016\/j.addr.2023.115086_b0575","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0959-8049(01)00171-X","article-title":"Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation","volume":"37","author":"Gelderblom","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.addr.2023.115086_b0580","first-page":"174","article-title":"The hidden culprit: a case of repeated anaphylaxis to cremophor, allergy asthma","volume":"8","author":"Kim","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.addr.2023.115086_b0585","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1345\/aph.19302","article-title":"Cyclosporine-induced anaphylaxis","volume":"34","author":"Kuiper","year":"2000","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.addr.2023.115086_b0590","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1200\/JCO.1990.8.7.1263","article-title":"Hypersensitivity reactions from taxol","volume":"8","author":"Weiss","year":"1990","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.addr.2023.115086_b0595","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/jnci\/90.4.300","article-title":"Complement activation by cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study","volume":"90","author":"Szebeni","year":"1998","journal-title":"J. Natl Cancer Inst."},{"key":"10.1016\/j.addr.2023.115086_b0600","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ejps.2011.09.016","article-title":"Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20","volume":"45","author":"Weiszh\u00e1r","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0605","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1208\/s12248-016-9928-8","article-title":"The effects of pharmaceutical excipients on gastrointestinal tract metabolic enzymes and transporters-an update","volume":"18","author":"Zhang","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2023.115086_b0610","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1021\/acs.molpharmaceut.0c00023","article-title":"Effect of common excipients on intestinal drug absorption in wistar rats","volume":"17","author":"Ruiz-Picazo","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0615","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/jps.21836","article-title":"Absorption barriers in the rat intestinal mucosa. 3: Effects of polyethoxylated solubilizing agents on drug permeation and metabolism","volume":"99","author":"Mudra","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0620","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.dmpk.2015.01.002","article-title":"Effects of cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects","volume":"30","author":"Tomaru","year":"2015","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.addr.2023.115086_b0625","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1365-2125.2002.01595.x","article-title":"Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL","volume":"53","author":"Martin-Facklam","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0630","first-page":"490","article-title":"Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in use for food for particular nutritional purposes","volume":"5","author":"E.F.S. Authority","year":"2007","journal-title":"EFSA J."},{"key":"10.1016\/j.addr.2023.115086_b0635","unstructured":"Food and Drug Administration (2002) Agenerase\u00ae capsules product information, NDA 21-007\/S-011 (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2002\/21007s11,21039s10lbl.pdf)."},{"key":"10.1016\/j.addr.2023.115086_b0640","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1023\/A:1015000503629","article-title":"Inhibition of p-glycoprotein by d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)","volume":"16","author":"Dintaman","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0645","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0928-0987(02)00055-6","article-title":"Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers","volume":"16","author":"Rege","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0650","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2005.11.005","article-title":"influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers","volume":"111","author":"Collnot","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b0655","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/mp060121r","article-title":"Mechanism of inhibition of p-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity","volume":"4","author":"Collnot","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0660","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejps.2005.04.003","article-title":"Enhanced oral paclitaxel absorption with vitamin E-TPGS: Effect on solubility and permeability in vitro, in situ and in vivo","volume":"25","author":"Varma","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0665","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1023\/A:1018939006780","article-title":"Vitamin E-TPGS increases absorption flux of an HIV protease inhibitor by enhancing its solubility and permeability","volume":"16","author":"Yu","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0670","first-page":"37","article-title":"Enhanced permeability of etoposide across everted sacs of rat small intestine by vitamin E-TPGS, iran","volume":"12","author":"Parsa","year":"2013","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0675","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1208\/ps040440","article-title":"An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on p-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine","volume":"4","author":"Johnson","year":"2002","journal-title":"AAPS PharmSci"},{"key":"10.1016\/j.addr.2023.115086_b0680","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1208\/s12249-011-9632-z","article-title":"Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats","volume":"12","author":"Chen","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2023.115086_b0685","doi-asserted-by":"crossref","unstructured":"G.D. Noudeh, P. Khazaeli, S. Mirzaei, F. Sharififar, S. Nasrollahosaiani, Determination of the toxicity effect of sorbitan esters surfactants group on biological membrane, (2009).","DOI":"10.3923\/jbs.2009.423.430"},{"key":"10.1016\/j.addr.2023.115086_b0690","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/pharmaceutics11050228","article-title":"Sex-dependence in the effect of pharmaceutical excipients: polyoxyethylated solubilising excipients increase oral drug bioavailability in male but not female rats","volume":"11","author":"Mai","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b0695","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/jphp.13072","article-title":"High-throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux-mediated transport","volume":"71","author":"Pollard","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0700","doi-asserted-by":"crossref","unstructured":"3 Final Report on the Safety Assessment of Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, Journal of the American College of Toxicology, 4 (1985) 65-121.","DOI":"10.3109\/10915818509078670"},{"key":"10.1016\/j.addr.2023.115086_b0705","doi-asserted-by":"crossref","unstructured":"E.Panel o.F. Additives, N.S.a.t. Food, A. Mortensen, F. Aguilar, R. Crebelli, A. Di Domenico, B. Dusemund, M.J. Frutos, P. Galtier, D. Gott, U. Gundert-Remy, J.-C. Leblanc, O. Lindtner, P. Moldeus, P. Mosesso, D. Parent-Massin, A. Oskarsson, I. Stankovic, I. Waalkens-Berendsen, R.A. Woutersen, M. Wright, M. Younes, P. Boon, D. Chrysafidis, R. G\u00fcrtler, P. Tobback, A. Altieri, A.M. Rincon, C. Lambr\u00e9, Re-evaluation of sorbitan monostearate (E 491), sorbitan tristearate (E 492), sorbitan monolaurate (E 493), sorbitan monooleate (E 494) and sorbitan monopalmitate (E 495) when used as food additives, EFSA Journal, 15 (2017) e04788.","DOI":"10.2903\/j.efsa.2017.4788"},{"key":"10.1016\/j.addr.2023.115086_b0710","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-5173(02)00347-2","article-title":"Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs","volume":"246","author":"Takahashi","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0715","doi-asserted-by":"crossref","unstructured":"Shaw D.J., (1992) The solid liquid interface, In: Introduction to Colloid and Surface Chemistry, Butterworth-Heinemann Ltd, p151-173.","DOI":"10.1016\/B978-0-08-050910-5.50010-4"},{"key":"10.1016\/j.addr.2023.115086_b0720","doi-asserted-by":"crossref","first-page":"110","DOI":"10.12788\/jhm.3124","article-title":"Things we do for no reason: Prescribing docusate for constipation in hospitalized adults","volume":"14","author":"Fakheri","year":"2019","journal-title":"J. Hosp. Med."},{"key":"10.1016\/j.addr.2023.115086_b0725","unstructured":"Comittee for Human Medicinal Products (2017) Sodium laurilsulfate used as an excipient, European Medicines Agency, EMA\/CHMP\/351898\/2014 corr. 1*."},{"key":"10.1016\/j.addr.2023.115086_b0730","unstructured":"US Food and Drug Administration, Sodium Lauryl Sulphate, Code of Federal Regulations Title 21, volume 3, Part 172 Food additives permitted for direct addition to food for human consumption, 21CFR172.822."},{"key":"10.1016\/j.addr.2023.115086_b0735","unstructured":"National Center for Biotechnology Information. \u201cPubChem Annotation Record for SODIUM LAURYL SULFATE, Source: Hazardous Substances Data Bank (HSDB)\u201d PubChem, https:\/\/pubchem.ncbi.nlm.nih.gov\/source\/hsdb\/1315#section=FIFRA-Requirements-(Complete). Accessed 14 July, 2021."},{"key":"10.1016\/j.addr.2023.115086_b0740","doi-asserted-by":"crossref","unstructured":"7 Final Report on the Safety Assessment of Sodium Lauryl Sulfate and Ammonium Lauryl Sulfate, Journal of the American College of Toxicology, 2 (1983) 127-181.","DOI":"10.3109\/10915818309142005"},{"key":"10.1016\/j.addr.2023.115086_b0745","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jps.3030370109","article-title":"Chronic oral toxicities of surface-active agents","volume":"37","author":"Fitzhugh","year":"1948","journal-title":"J. Am. Pharm. Assoc. Am. Pharm. Assoc."},{"key":"10.1016\/j.addr.2023.115086_b0750","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0041-008X(62)90050-9","article-title":"Toxicologic studies on sodium lauryl glyceryl ether sulfonate and sodium lauryl trioxyethylene sulfate","volume":"4","author":"Tusing","year":"1962","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0755","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.2042-7158.1998.tb03319.x","article-title":"Cytotoxicity of absorption enhancers in Caco-2 cell monolayers","volume":"50","author":"Sakai","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0760","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11010041","article-title":"Application of permeation enhancers in oral delivery of macromolecules: an update","volume":"11","author":"Maher","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b0765","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s11095-008-9542-2","article-title":"Mechanistic analysis of chemical permeation enhancers for oral drug delivery","volume":"25","author":"Whitehead","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0770","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/jps.20007","article-title":"Cytotoxicity evaluation of enzyme inhibitors and absorption enhancers in Caco-2 cells for oral delivery of salmon calcitonin","volume":"93","author":"Shah","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0775","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0378-5173(95)00041-G","article-title":"Sodium lauryl sulphate increases tiludronate paracellular transport using human epithelial caco-2 monolayers","volume":"123","author":"Boulenc","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0780","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/BF01638303","article-title":"Action of surface-active substances on biological membranes I. Effect of chemical modification of membranes on hemolysis of erythrocytes by sodium alkyl sulfates","volume":"256","author":"Ossipov","year":"1978","journal-title":"Colloid Polymer Sci."},{"key":"10.1016\/j.addr.2023.115086_b0785","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/jps.2600651011","article-title":"Interaction of sodium alkyl sulfates with everted rat small intestinal membrane","volume":"65","author":"Feldman","year":"1976","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0790","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1211\/0022357991776976","article-title":"Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-D-maltopyranoside","volume":"51","author":"Uchiyama","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0795","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.2042-7158.1979.tb13501.x","article-title":"Relative effects of different surfactants on intestinal absorption and the release of proteins and phospholipids from the tissue","volume":"31","author":"Whitmore","year":"1979","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0800","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1023\/A:1018984731584","article-title":"Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility","volume":"11","author":"Swenson","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0805","first-page":"1","article-title":"Absorption enhancers","volume":"7","author":"Muranishi","year":"1990","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.addr.2023.115086_b0810","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5173(98)00288-9","article-title":"The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations","volume":"176","author":"Baluom","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0815","doi-asserted-by":"crossref","unstructured":"K. Nakanishi, M. Masada, T. Nadai, Effect of pharmaceutical adjuvants on the rectal permeability of drugs. III. Effect of repeated administration and recovery of the permeability, Chem Pharm Bull (Tokyo), 31 (1983) 4161-4166.","DOI":"10.1248\/cpb.31.4161"},{"key":"10.1016\/j.addr.2023.115086_b0820","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12016-018-8713-0","article-title":"Irritant contact dermatitis","volume":"56","author":"Bains","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.addr.2023.115086_b0825","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.addr.2009.09.006","article-title":"Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic","volume":"61","author":"Maher","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2023.115086_b0830","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.xphs.2021.08.001","article-title":"An assessment of occasional bio-inequivalence for BCS1 and BCS3 drugs: what are the underlying reasons?","volume":"111","author":"Butler","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0835","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1021\/acs.molpharmaceut.7b00353","article-title":"Preclinical effect of absorption modifying excipients on rat intestinal transport of model compounds and the mucosal barrier marker (51)Cr-EDTA","volume":"14","author":"Dahlgren","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0840","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/pharmaceutics12030242","article-title":"Regional intestinal drug permeability and effects of permeation enhancers in rat","volume":"12","author":"Dahlgren","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b0845","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2018.05.029","article-title":"the effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs","volume":"547","author":"Dahlgren","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0850","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejpb.2018.09.001","article-title":"Time-dependent effects on small intestinal transport by absorption-modifying excipients","volume":"132","author":"Dahlgren","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115086_b0855","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.3390\/ijms21186771","article-title":"Prevention of rat intestinal injury with a drug combination of melatonin and misoprostol","volume":"21","author":"Dahlgren","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0860","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1529\/biophysj.105.077867","article-title":"Thermodynamics of lipid membrane solubilization by sodium dodecyl sulfate","volume":"90","author":"Keller","year":"2006","journal-title":"Biophys. J ."},{"key":"10.1016\/j.addr.2023.115086_b0865","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/abbi.1999.1267","article-title":"Solubilization of liposomes by sodium dodecyl sulfate: new mechanism based on the direct formation of mixed micelles","volume":"367","author":"L\u00f3pez","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.addr.2023.115086_b0870","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/jp108653e","article-title":"Observing the solubilization of lipid bilayers by detergents with optical microscopy of GUVs","volume":"115","author":"Sudbrack","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.addr.2023.115086_b0875","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2116\/analsci.28.345","article-title":"Anomalous solubilization behavior of dimyristoylphosphatidylcholine liposomes induced by sodium dodecyl sulfate micelles","volume":"28","author":"Igarashi","year":"2012","journal-title":"Anal. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0880","doi-asserted-by":"crossref","first-page":"11499","DOI":"10.1021\/acs.langmuir.0c01810","article-title":"the mechanism of vesicle solubilization by the detergent sodium dodecyl sulfate","volume":"36","author":"Juan-Col\u00e1s","year":"2020","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2023.115086_b0885","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/fsn3.2108","article-title":"Agar oligosaccharides ameliorate the intestinal inflammation of male drosophila melanogaster via modulating the microbiota, and immune and cell autophagy","volume":"9","author":"Ma","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.addr.2023.115086_b0890","unstructured":"E.F.S. Authority, Tolerable upper intake levels for vitamins and minerals, Scientific Committee on Food, (2006)."},{"key":"10.1016\/j.addr.2023.115086_b0895","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.toxrep.2017.10.003","article-title":"Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential","volume":"4","author":"Hobbs","year":"2017","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.addr.2023.115086_b0900","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1104\/pp.109.146282","article-title":"Soybean oil: genetic approaches for modification of functionality and total content","volume":"151","author":"Clemente","year":"2009","journal-title":"Plant Physiol."},{"key":"10.1016\/j.addr.2023.115086_b0905","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4314\/gmj.v50i3.11","article-title":"Coconut oil and palm oil's role in nutrition, health and national development: a review","volume":"50","author":"Boateng","year":"2016","journal-title":"Ghana Med. J."},{"key":"10.1016\/j.addr.2023.115086_b0910","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1208\/s12249-014-0076-0","article-title":"the role of caprylate ligand ion on the stabilization of human serum albumin","volume":"15","author":"Faroongsarng","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2023.115086_b0915","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.colsurfa.2008.10.026","article-title":"intramolecular and intermolecular ion\u2013dipole interactions in sodium lauryl ether sulfates (SLES) self-aggregation and mixed micellization with triton X-100","volume":"335","author":"Aoudia","year":"2009","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"10.1016\/j.addr.2023.115086_b0920","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5935\/0103-5053.20130031","article-title":"Time-resolved fluorescence quenching studies of sodium lauryl ether sulfate micelles","volume":"24","author":"Friedrich","year":"2013","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.addr.2023.115086_b0925","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1034\/j.1600-0536.2003.480105.x","article-title":"Profile of irritant patch testing with detergents: sodium lauryl sulfate, sodium laureth sulfate and alkyl polyglucoside","volume":"48","author":"L\u00f6ffler","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.addr.2023.115086_b0930","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1015930821648","article-title":"Site dependence of absorption-promoting actions of Laureth-9, na salicylate, na 2 EDTA, and aprotinin on rectal, nasal, and buccal insulin delivery","volume":"5","author":"Aungst","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b0935","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jps.2600640621","article-title":"Effect of surfactants on absorption through membranes IV: effects of dioctyl sodium sulfosuccinate on absorption of a poorly absorbable drug, phenolsulfonphthalein, in humans","volume":"64","author":"Khalafallah","year":"1975","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b0940","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/jphp.13021","article-title":"Self-emulsifying drug delivery systems and cationic surfactants: do they potentiate each other in cytotoxicity?","volume":"71","author":"Lam","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b0945","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/toxsci\/kfy045","article-title":"Effects of consumer antimicrobials benzalkonium chloride, benzethonium chloride, and chloroxylenol on colonic inflammation and Colitis-Associated Colon tumorigenesis in mice, toxicological sciences : an official journal of the society of","volume":"163","author":"Sanidad","year":"2018","journal-title":"Toxicology"},{"key":"10.1016\/j.addr.2023.115086_b0950","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/10915818909010524","article-title":"2 final report on the safety assessment of benzalkonium chloride","volume":"8","author":"Liebert","year":"1989","journal-title":"J. Am. Coll. Toxicol."},{"key":"10.1016\/j.addr.2023.115086_b0955","unstructured":"Committee for Human Medicinal Products (2017), Benzalkonium chloride used as an excipient, European Medicines Agency, EMA\/CHMP\/352187\/2012."},{"key":"10.1016\/j.addr.2023.115086_b0960","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0168-3659(92)90007-E","article-title":"A novel in vitro screen to discover agents which increase the absorption of molecules across the intestinal epithelium","volume":"21","author":"Schasteen","year":"1992","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b0965","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1159\/000354707","article-title":"Lecithin as a therapeutic agent in ulcerative colitis","volume":"31","author":"Stremmel","year":"2013","journal-title":"Dig. Dis."},{"key":"10.1016\/j.addr.2023.115086_b0970","doi-asserted-by":"crossref","unstructured":"E.P.o. Additives, P.o.S.u.i.A. Feed, Safety and efficacy of lecithins for all animal species, EFSA Journal, 14 (2016) e04561.","DOI":"10.2903\/j.efsa.2016.4561"},{"key":"10.1016\/j.addr.2023.115086_b0975","first-page":"e04742","article-title":"Re-evaluation of lecithins (E 322) as a food additive","volume":"15","author":"Mortensen","year":"2017","journal-title":"EFSA J."},{"key":"10.1016\/j.addr.2023.115086_b0980","doi-asserted-by":"crossref","unstructured":"K.F. Tiefenbacher, Chapter Three - Technology of Main Ingredients\u2014Sweeteners and Lipids, in: K.F. Tiefenbacher (Ed.) Wafer and Waffle, Academic Press2017, pp. 123-225.","DOI":"10.1016\/B978-0-12-809438-9.00003-X"},{"key":"10.1016\/j.addr.2023.115086_b0985","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1271\/bbb.66.730","article-title":"Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells","volume":"66","author":"Ishizuka","year":"2002","journal-title":"Biosci. Biotech. Bioch."},{"key":"10.1016\/j.addr.2023.115086_b0990","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0378-5173(94)00232-T","article-title":"Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines","volume":"114","author":"Hovgaard","year":"1995","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b0995","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/gut.26.4.369","article-title":"Lysophosphatidylcholine increases rat ileal permeability to macromolecules","volume":"26","author":"Tagesson","year":"1985","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1000","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3109\/00365528109181820","article-title":"Passage of molecules through the wall of the gastrointestinal tract","volume":"16","author":"Bolin","year":"1981","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1005","first-page":"G870","article-title":"Experimental gastritis: are the detergents on or in the mucosa?, american journal of Physiology-Gastrointestinal and liver","volume":"251","author":"Schweitzer","year":"1986","journal-title":"Physiology"},{"key":"10.1016\/j.addr.2023.115086_b1010","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.15.9.710","article-title":"Lysolecithin: a factor in the pathogenesis of gastric ulceration?","volume":"15","author":"Johnson","year":"1974","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejps.2017.07.008","article-title":"Review \u2013 An update on the use of oral phospholipid excipients","volume":"108","author":"van Hoogevest","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ejps.2006.04.016","article-title":"formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system","volume":"29","author":"Pouton","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1025","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.addr.2007.09.010","article-title":"Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective","volume":"60","author":"Chen","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2023.115086_b1030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3748\/wjg.v19.i2.299","article-title":"Lubiprostone induced ischemic colitis","volume":"19","author":"Sherid","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/17425247.2021.1825375","article-title":"intestinal permeation enhancers to improve oral bioavailability of macromolecules: reasons for low efficacy in humans","volume":"18","author":"Maher","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2023.115086_b1040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0169-409X(00)00063-6","article-title":"Oral delivery of salmon calcitonin","volume":"42","author":"Lee","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2023.115086_b1045","first-page":"313","article-title":"Formulation strategies to improve oral peptide delivery, pharmaceutical patent","volume":"3","author":"Maher","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.addr.2023.115086_b1050","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1023\/A:1012112219578","article-title":"Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate","volume":"14","author":"Lindmark","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1055","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.4155\/tde.11.132","article-title":"Oral delivery of macromolecules: rationale underpinning gastrointestinal permeation enhancement technology (GIPET)","volume":"2","author":"Walsh","year":"2011","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2023.115086_b1060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S2213-8587(18)30372-3","article-title":"Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial","volume":"7","author":"Halberg","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.addr.2023.115086_b1065","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jacc.2023.02.018","article-title":"Phase 2b randomized trial of the oral PCSK9 inhibitor MK-0616","volume":"81","author":"Ballantyne","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.addr.2023.115086_b1070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejps.2009.09.001","article-title":"Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in isolated rat and human colonic mucosae","volume":"38","author":"Maher","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4155\/tde.10.5","article-title":"Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate","volume":"1","author":"Wang","year":"2010","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.addr.2023.115086_b1080","article-title":"Formulation strategies to improve the efficacy of intestinal permeation enhancers","volume":"113925","author":"Maher","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2023.115086_b1085","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s11095-014-1303-9","article-title":"A novel suspension formulation enhances intestinal absorption of macromolecules Via transient and reversible transport mechanisms","volume":"31","author":"Tuvia","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1090","unstructured":"US20100105627A1 Chiasma Inc (2010)."},{"key":"10.1016\/j.addr.2023.115086_b1095","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1023\/A:1015992819290","article-title":"Enhancement of colonic drug absorption by the transcellular permeation route","volume":"5","author":"Tomita","year":"1988","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1100","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1210\/jc.2012-1179","article-title":"Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression","volume":"97","author":"Tuvia","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2023.115086_b1105","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1210\/jc.2014-4113","article-title":"Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial","volume":"100","author":"Melmed","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2023.115086_b1110","doi-asserted-by":"crossref","first-page":"A517","DOI":"10.1210\/jendso\/bvab048.1056","article-title":"A phase 3 large international noninferiority trial (MPOWERED): Assessing maintenance of response to oral octreotide capsules in comparison to injectable somatostatin receptor ligands","volume":"5","author":"Fleseriu","year":"2021","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.addr.2023.115086_b1115","doi-asserted-by":"crossref","DOI":"10.1208\/s12248-020-00490-9","article-title":"The effects of dose volume and excipient dose on luminal concentration and oral drug absorption","volume":"22","author":"Aungst","year":"2020","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2023.115086_b1120","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2036.2005.02683.x","article-title":"Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging","volume":"22","author":"Schiller","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2023.115086_b1125","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1021\/mp500210c","article-title":"Quantification of gastrointestinal liquid volumes and distribution following a 240 mL dose of water in the fasted state","volume":"11","author":"Mudie","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1130","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1023\/A:1018819012405","article-title":"Biopharmaceutical approaches for developing and assessing oral peptide delivery strategies and systems: in vitro permeability and in vivo oral absorption of salmon calcitonin","volume":"16","author":"Sinko","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/acs.molpharmaceut.1c00724","article-title":"Impact of intestinal concentration and colloidal structure on the Permeation-Enhancing efficiency of sodium caprate in the Rat","volume":"19","author":"Berg","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1140","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1016\/j.xphs.2016.02.026","article-title":"Effect of absorption behavior of solubilizers on drug dissolution in the gastrointestinal tract: Evaluation based on in vivo luminal Concentration-Time profile of cilostazol, a poorly soluble drug, and solubilizers","volume":"105","author":"Tanaka","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1145","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jps.20553","article-title":"intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir","volume":"95","author":"Brouwers","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1150","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/00365520600610451","article-title":"Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study","volume":"41","author":"Steingoetter","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1155","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s11095-012-0931-1","article-title":"Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: analysis of Intragastric fluid dynamics and drug absorption","volume":"30","author":"Yamashita","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1160","doi-asserted-by":"crossref","unstructured":"Which prophylactic aspirin?, Drug and Therapeutics Bulletin, 35 (1997) 7-8.","DOI":"10.1136\/dtb.1997.3517"},{"key":"10.1016\/j.addr.2023.115086_b1165","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar7047","article-title":"Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist","volume":"10","author":"Buckley","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2023.115086_b1170","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1021\/acs.molpharmaceut.2c00443","article-title":"In vivo mechanism of action of sodium caprate for improving the intestinal absorption of a GLP1\/GIP coagonist peptide","volume":"20","author":"Tran","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_bib1886","doi-asserted-by":"crossref","first-page":"124388","DOI":"10.1016\/j.ijbiomac.2023.124388","article-title":"Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer","volume":"240","author":"Naranjani","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.addr.2023.115086_b1175","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.27.8.886","article-title":"Transit of pharmaceutical dosage forms through the small intestine","volume":"27","author":"Davis","year":"1986","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpharm.2010.04.045","article-title":"the transit of dosage forms through the small intestine","volume":"395","author":"Yuen","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1185","series-title":"Controlled Release in oral Drug Delivery","first-page":"27","article-title":"the organization of the gut and the oral absorption of drugs: Anatomical, biological and physiological considerations in oral formulation development","author":"Wilson","year":"2011"},{"key":"10.1016\/j.addr.2023.115086_b1190","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1021\/mp100149j","article-title":"Physiological parameters for oral delivery and in vitro testing","volume":"7","author":"Mudie","year":"2010","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1195","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1111\/j.1600-6143.2012.04148.x","article-title":"What Is the normal small bowel length in humans?First Donor-Based cohort analysis","volume":"12","author":"Gondolesi","year":"2012","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.addr.2023.115086_b1200","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0016-5085(82)90314-6","article-title":"Relationship of motility to flow of contents in the human small intestine","volume":"82","author":"Kerlin","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1205","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1023\/A:1007596821702","article-title":"Regional differences in intestinal spreading and pH recovery and the impact on salmon calcitonin absorption in dogs","volume":"17","author":"Lee","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1210","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1023\/A:1018991713064","article-title":"Enhanced bioavailability of cefoxitin using palmitoylcarnitine. II. Use of directly compressed tablet formulations in the rat and dog","volume":"10","author":"Sutton","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1215","unstructured":"F.S. Commission, Evaluation Report of Food Additives Polysorbates(Polysorbates 20, 60, 65 and 80), 2012."},{"key":"10.1016\/j.addr.2023.115086_b1220","first-page":"377","article-title":"intermediary metabolism of certain polyoxyethylene derivatives in man. I. Recovery of the polyoxyethylene moiety from urine and faces following ingestion of polyoxyethylene (40) mono-stearate","volume":"103","author":"Culver","year":"1951","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2023.115086_b1225","series-title":"Introduction to Colloid and Surface Chemistry","first-page":"64","article-title":"Liquid-gas and liquid-liquid interfaces","author":"Shaw","year":"1992"},{"key":"10.1016\/j.addr.2023.115086_b1230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.18433\/jpps30347","article-title":"Understanding the role of sodium lauryl sulfate on the biorelevant solubility of a combination of poorly Water-Soluble drugs using high throughput experimentation and mechanistic absorption modeling","volume":"22","author":"Bahr","year":"2019","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1235","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11743-013-1449-1","article-title":"Counter-ion effect on micellization of ionic surfactants: a comprehensive understanding with two representatives, sodium dodecyl sulfate (SDS) and Dodecyltrimethylammonium Bromide (DTAB)","volume":"16","author":"Naskar","year":"2013","journal-title":"J. Surfactant Deterg."},{"key":"10.1016\/j.addr.2023.115086_b1240","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijpharm.2018.07.057","article-title":"Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport","volume":"549","author":"Dahlgren","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1245","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1023\/A:1018909210879","article-title":"Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route","volume":"10","author":"Anderberg","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1250","article-title":"the in vivo effect of transcellular permeation enhancers on the intestinal permeability of two peptide drugs enalaprilat and hexarelin","volume":"12","author":"Dahlgren","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b1255","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10863-010-9310-y","article-title":"Influence of the albumin concentration and temperature on the lysis of human erythrocytes by sodium dodecyl sulfate","volume":"42","author":"Fonseca","year":"2010","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.addr.2023.115086_b1260","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0005-2795(79)90088-6","article-title":"Precipitation of egg white proteins below their isoelectric points by sodium dodecyl sulphate and temperature","volume":"579","author":"Hegg","year":"1979","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.addr.2023.115086_b1265","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1023\/B:PHAM.0000012162.52419.b3","article-title":"Effect of sodium lauryl sulfate in dissolution media on dissolution of hard gelatin capsule shells","volume":"21","author":"Zhao","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1270","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/jps.21118","article-title":"Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers","volume":"97","author":"Tippin","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1275","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1021\/acs.molpharmaceut.0c00668","article-title":"Influence of bile composition on membrane incorporation of transient permeability enhancers","volume":"17","author":"Hossain","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/pr10010029","article-title":"Explicit-pH coarse-grained molecular dynamics simulations enable insights into restructuring of intestinal colloidal aggregates with permeation enhancers","volume":"10","author":"Hossain","year":"2022","journal-title":"Processes"},{"key":"10.1016\/j.addr.2023.115086_b1285","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.xphs.2018.02.012","article-title":"Labrasol(\u00ae) and salts of Medium-Chain fatty acids can be combined in low concentrations to increase the permeability of a macromolecule marker across isolated Rat intestinal mucosae","volume":"107","author":"Heade","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1290","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1021\/la020672y","article-title":"Effect of premicellar aggregation on the pKa of fatty acid soap solutions","volume":"19","author":"Kanicky","year":"2003","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2023.115086_b1295","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1208\/s12249-018-1289-4","article-title":"Aggregation behavior of medium chain fatty acids studied by Coarse-Grained molecular dynamics simulation","volume":"20","author":"Hossain","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2023.115086_b1300","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/acs.molpharmaceut.1c00689","article-title":"In Silico-Based experiments on mechanistic interactions between several intestinal permeation enhancers with a lipid bilayer model","volume":"19","author":"Kneiszl","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1305","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/jn\/119.8.1100","article-title":"interaction of bile acids, phospholipids, cholesterol and triglyceride with dietary fibers in the small intestine of rats","volume":"119","author":"Ebihara","year":"1989","journal-title":"J. Nutr."},{"key":"10.1016\/j.addr.2023.115086_b1310","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1039\/c0fo00080a","article-title":"Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides","volume":"1","author":"Gunness","year":"2010","journal-title":"Food Funct."},{"key":"10.1016\/j.addr.2023.115086_b1315","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082193","article-title":"Differentiation of adsorptive and viscous effects of dietary fibres on bile acid release by means of in vitro digestion and dialysis","volume":"19","author":"Naumann","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1320","doi-asserted-by":"crossref","first-page":"R938","DOI":"10.1016\/j.cub.2021.06.093","article-title":"Mucus","volume":"31","author":"McShane","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.addr.2023.115086_b1325","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1371\/journal.pbio.0040276","article-title":"Disruption-induced mucus secretion: repair and protection","volume":"4","author":"Miyake","year":"2006","journal-title":"PLoS Biol."},{"key":"10.1016\/j.addr.2023.115086_b1330","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5173(01)00897-3","article-title":"Simulated intestinal fluid as transport medium in the Caco-2 cell culture model","volume":"232","author":"Ingels","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1335","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejps.2007.08.002","article-title":"Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms","volume":"32","author":"Lind","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1340","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejps.2018.02.032","article-title":"Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium","volume":"118","author":"Birch","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1345","first-page":"G921","article-title":"Adaptive cytoprotection in the small intestine: role of mucus","volume":"264","author":"Cepinskas","year":"1993","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b1350","first-page":"G1067","article-title":"Epidermal growth factor attenuates jejunal mucosal injury induced by oleic acid: role of mucus","volume":"267","author":"Ishikawa","year":"1994","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b1355","article-title":"The role and function of mucins and its relationship to inflammatory bowel disease","volume":"9","author":"Kang","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.addr.2023.115086_b1360","first-page":"543","article-title":"Modulating intestinal mucus barrier for nanoparticles penetration by surfactants","volume":"14","author":"Zhang","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1365","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1023\/A:1010607127822","article-title":"Effect of bile salts on colonic mucus secretion in isolated vascularly perfused rat colon","volume":"46","author":"Barcelo","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1370","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF01395507","article-title":"Dose-related effects of chenodeoxycholic acid in the rabbit colon","volume":"25","author":"Camilleri","year":"1980","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1375","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1136\/gutjnl-2018-317571","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","volume":"68","author":"van der Post","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1380","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1023\/A:1026449527891","article-title":"Synchronized release of sulpiride and sodium decanoate from HPMC matrices: a rational approach to enhance sulpiride absorption in the rat intestine","volume":"17","author":"Baluom","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1385","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2125.1989.tb05337.x","article-title":"Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers","volume":"27","author":"Van Hoogdalem","year":"1989","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b1390","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1021\/acsomega.0c05532","article-title":"The impact of micelle formation on surfactant adsorption-desorption","volume":"6","author":"Groenendijk","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.addr.2023.115086_b1395","unstructured":"US Food and Drug Administration, Polysorbate 80, Code of Federal Regulations Title 21, volume 3, Part 172 Food additives permitted for direct addition to food for human consumption, 21CFR172.840."},{"key":"10.1016\/j.addr.2023.115086_b1400","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/jps.2600600412","article-title":"Effects of interaction with surfactants, adsorbents, and other substances on the permeation of chlorpromazine through a dimethyl polysiloxane membrane","volume":"60","author":"Nakano","year":"1971","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1405","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1211\/jpp.60.12.0003","article-title":"Physicochemical interactions between drugs and superdisintegrants","volume":"60","author":"Frans\u00e9n","year":"2008","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b1410","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1023\/A:1016084824877","article-title":"Excipient interaction with cetylpyridinium chloride activity in tablet based lozenges","volume":"13","author":"Richards","year":"1996","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1415","first-page":"G498","article-title":"intestinal absorption of sodium dodecyl sulfate in the rodent: evidence for paracellular absorption","volume":"272","author":"Amelsberg","year":"1997","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b1420","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s40262-019-00772-2","article-title":"the effect of food intake on the pharmacokinetics of oral basal insulin: a randomised crossover trial in healthy male subjects","volume":"58","author":"Halberg","year":"2019","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.addr.2023.115086_b1425","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijpharm.2015.12.043","article-title":"absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs including peptide and protein drugs in rats","volume":"499","author":"Alama","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1430","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1023\/A:1015840921203","article-title":"Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate","volume":"8","author":"Sawada","year":"1991","journal-title":"Pharm. Res."},{"key":"10.1016\/j.addr.2023.115086_b1435","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11110565","article-title":"Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and In vivo studies","volume":"11","author":"McCartney","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b1440","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejps.2012.08.010","article-title":"Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers","volume":"47","author":"Petersen","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1445","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/10611860400020191","article-title":"Tetradecylmaltoside (TDM) enhances in vitro and in vivo intestinal absorption of enoxaparin, a low molecular weight heparin","volume":"13","author":"Yang","year":"2005","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2023.115086_b1450","first-page":"32","article-title":"Permeability enhancing effects of the alkylglycoside, octylglucoside, on insulin permeation across epithelial membrane in vitro","volume":"9","author":"Tirumalasetty","year":"2006","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1455","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/cs0970385","article-title":"interleukin-8 stimulates the migration of human colonic epithelial cells in vitro","volume":"97","author":"Wilson","year":"1999","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.addr.2023.115086_b1460","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/gut.38.2.216","article-title":"increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease","volume":"38","author":"Daig","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1465","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejpb.2015.05.013","article-title":"Sodium caprate-induced increases in intestinal permeability and epithelial damage are prevented by misoprostol","volume":"94","author":"Brayden","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2023.115086_b1470","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jconrel.2013.05.002","article-title":"A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine","volume":"172","author":"Gupta","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b1475","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0022-3565(24)37802-4","article-title":"Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells","volume":"287","author":"Duizer","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.addr.2023.115086_b1480","first-page":"237","article-title":"Rapid barrier restitution in an in vitro model of intestinal epithelial injury","volume":"60","author":"Moore","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2023.115086_b1485","first-page":"G62","article-title":"Restitution of barrier and transport function of porcine colon after acute mucosal injury","volume":"255","author":"Argenzio","year":"1988","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b1490","doi-asserted-by":"crossref","first-page":"G967","DOI":"10.1152\/ajpgi.00532.2002","article-title":"PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum","volume":"285","author":"Gookin","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2023.115086_b1495","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3109\/00365529709011204","article-title":"Effect of growth factors on epithelial restitution of human colonic mucosa in vitro","volume":"32","author":"Riegler","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1500","first-page":"72","article-title":"Morphologic and functional effects of bile salt on the porcine colon during injury and repair","volume":"60","author":"Henrikson","year":"1989","journal-title":"Lab. Invest."},{"key":"10.1016\/j.addr.2023.115086_b1505","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1023\/A:1026295014525","article-title":"Diversity of restitution after deoxycholic acid-induced small intestinal mucosal injury in the rat","volume":"48","author":"Masuda","year":"2003","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1510","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijpharm.2003.11.013","article-title":"in situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer","volume":"271","author":"Rama Prasad","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1515","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijpharm.2006.02.053","article-title":"Synergistic absorption enhancement of salmon calcitonin and reversible mucosal injury by applying a mucolytic agent and a non-ionic surfactant","volume":"316","author":"Takatsuka","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1520","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1517\/17425247.3.5.685","article-title":"Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET\u2122","volume":"3","author":"Leonard","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2023.115086_b1525","unstructured":"K.C. Fein, J.P. Gleeson, K. Cochran, N.G. Lamson, R. Doerfler, J.R. Melamed, K.A. Whitehead, Long-term daily oral administration of intestinal permeation enhancers is safe and effective in mice, Bioengineering & Translational Medicine, n\/a e10342."},{"key":"10.1016\/j.addr.2023.115086_b1530","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/flgastro-2013-100316","article-title":"Drug-induced gastrointestinal disorders","volume":"5","author":"Philpott","year":"2014","journal-title":"Frontline Gastroenterol"},{"key":"10.1016\/j.addr.2023.115086_b1535","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1517\/14740338.5.4.585","article-title":"Drug-induced side effects affecting the gastrointestinal tract","volume":"5","author":"Leong","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.addr.2023.115086_b1540","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s40268-016-0171-7","article-title":"Drug exposure and the risk of microscopic colitis: A critical update","volume":"17","author":"Lucendo","year":"2017","journal-title":"Drugs R D"},{"key":"10.1016\/j.addr.2023.115086_b1545","unstructured":"E. Faerber, R. Wagner, D. Prasa, B. Plenert, S. Stoletzki, U. Stedtler, M. Hermanns-Clausen, Gastrointestinal symptoms after oral ingestion of cleaners and cosmetic products containing surfactant: results from a prospective multicentre study in Germany, CLINICAL TOXICOLOGY, INFORMA HEALTHCARE 52 VANDERBILT AVE, NEW YORK, NY 10017 USA, 2012, pp. 337-337."},{"key":"10.1016\/j.addr.2023.115086_b1550","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1900\/RDS.2014.11.202","article-title":"Adverse effects of GLP-1 receptor agonists","volume":"11","author":"Filippatos","year":"2014","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.addr.2023.115086_b1555","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1053\/j.gastro.2005.03.020","article-title":"A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy","volume":"128","author":"Maiden","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1560","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1542-3565(04)00603-2","article-title":"Visible small-intestinal mucosal injury in chronic NSAID users","volume":"3","author":"Graham","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2023.115086_b1565","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.43.4.506","article-title":"intestinal permeability and inflammation in patients on NSAIDs","volume":"43","author":"Sigthorsson","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1570","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3748\/wjg.v19.i6.889","article-title":"Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy","volume":"19","author":"Racz","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1575","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1542\/peds.91.5.927","article-title":"The mystery ingredients: sweeteners, flavorings, dyes, and preservatives in analgesic\/antipyretic, antihistamine\/decongestant, cough and cold, antidiarrheal, and liquid theophylline preparations","volume":"91","author":"Kumar","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.addr.2023.115086_b1580","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103402","article-title":"The role of carrageenan in inflammatory bowel diseases and allergic reactions: Where do We stand?","volume":"13","author":"Borsani","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2023.115086_b1585","doi-asserted-by":"crossref","unstructured":"E.F.S. Authority, EFSA's activities on emerging risks in 2014, EFSA Supporting Publications, 12 (2015) 838E.","DOI":"10.2903\/sp.efsa.2015.EN-838"},{"key":"10.1016\/j.addr.2023.115086_b1590","doi-asserted-by":"crossref","unstructured":"E.F.S. Authority, A. Afonso, R. Garcia Matas, A. Maggiore, C. Merten, A. Yin, T. Robinson, EFSA's activities on emerging risks in 2018, EFSA Supporting Publications, 16 (2019) 1704E.","DOI":"10.2903\/sp.efsa.2019.EN-1704"},{"key":"10.1016\/j.addr.2023.115086_b1595","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1600","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1097\/MIB.0000000000000110","article-title":"Partial enteral nutrition with a crohn's disease exclusion diet is effective for induction of remission in children and young adults with crohn's disease","volume":"20","author":"Sigall-Boneh","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.addr.2023.115086_b1605","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.12.002","article-title":"Treatment of active crohn\u2019s disease with an ordinary food-based diet that replicates exclusive enteral nutrition","volume":"156","author":"Svolos","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1610","doi-asserted-by":"crossref","unstructured":"A. Levine, E. Wine, A. Assa, R.S. Boneh, R. Shaoul, M. Kori, S. Cohen, S. Peleg, H. Shamaly, A. On, Crohn\u2019s disease exclusion diet plus partial enteral nutrition induces sustained remission in a randomized controlled trial, Gastroenterology, 157 (2019) 440-450. e448.","DOI":"10.1053\/j.gastro.2019.04.021"},{"key":"10.1016\/j.addr.2023.115086_b1615","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S1461-5347(00)00302-3","article-title":"Enhancing paracellular permeability by modulating epithelial tight junctions","volume":"3","author":"Ward","year":"2000","journal-title":"Pharm. Sci. Technol. Today"},{"key":"10.1016\/j.addr.2023.115086_b1620","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yrtph.2011.02.010","article-title":"Excipients in medicinal products used in gastroenterology as a possible cause of side effects","volume":"60","author":"Ursino","year":"2011","journal-title":"Regul. Toxicol. Pharm."},{"key":"10.1016\/j.addr.2023.115086_b1625","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/jbm.a.36324","article-title":"Alternative foaming agents for topical treatment of ulcerative colitis","volume":"106","author":"Asama","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.addr.2023.115086_b1630","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2036.2006.02743.x","article-title":"budesonide foam versus budesonide enema in active ulcerative proctitis and proctosigmoiditis","volume":"23","author":"Gross","year":"2006","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2023.115086_b1635","article-title":"intestinal mucosal wound healing and barrier integrity in IBD-Crosstalk and trafficking of cellular players","volume":"8","author":"Sommer","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.addr.2023.115086_b1640","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/bmj.282.6258.91","volume":"282","author":"Aspirin and the stomach","year":"1981","journal-title":"Br. Med. J. (Clin. Res. Ed)"},{"key":"10.1016\/j.addr.2023.115086_b1645","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.3892\/ol.2020.11817","article-title":"Effects of aspirin on the gastrointestinal tract: Pros vs. cons","volume":"20","author":"Li","year":"2020","journal-title":"Oncol. Lett."},{"issue":"Suppl 1","key":"10.1016\/j.addr.2023.115086_b1650","doi-asserted-by":"crossref","first-page":"50s","DOI":"10.1016\/S0248-8663(00)88725-1","article-title":"Digestive complications of aspirin","volume":"21","author":"Hochain","year":"2000","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.addr.2023.115086_b1655","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijcard.2010.10.027","article-title":"Prevalence and clinical impact of upper gastrointestinal symptoms in subjects treated with low dose aspirin: the UGLA survey","volume":"156","author":"Cayla","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.addr.2023.115086_b1660","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","article-title":"Peptic ulcer disease","volume":"374","author":"Malfertheiner","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2023.115086_b1665","doi-asserted-by":"crossref","first-page":"G927","DOI":"10.1152\/ajpgi.00236.2012","article-title":"Acetyl salicylic acid induces damage to intestinal epithelial cells by oxidation-related modifications of ZO-1","volume":"303","author":"Fukui","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2023.115086_b1670","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0002-9343(89)90344-6","article-title":"Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage","volume":"86","author":"Schoen","year":"1989","journal-title":"Am. J. Med."},{"key":"10.1016\/j.addr.2023.115086_b1675","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/0016-5085(89)90506-4","article-title":"Effect of barrier-breaking agents on intracellular pH and epithelial membrane resistances: studies in isolated necturus antral mucosa exposed to luminal acid","volume":"96","author":"Kiviluoto","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1680","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/00365517609054490","article-title":"Salicylate- and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach","volume":"36","author":"Jorgensen","year":"1976","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.addr.2023.115086_b1685","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1211\/jpp.58.10.0001","article-title":"NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes","volume":"58","author":"Lichtenberger","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b1690","doi-asserted-by":"crossref","first-page":"13572","DOI":"10.1021\/jp405364c","article-title":"Motion and interaction of aspirin crystals at aqueous-air interfaces","volume":"117","author":"B\u00e1ns\u00e1gi","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.addr.2023.115086_b1695","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.gastro.2004.04.003","article-title":"The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice","volume":"127","author":"Darling","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1700","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nm0295-154","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury","volume":"1","author":"Lichtenberger","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2023.115086_b1705","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1152\/physrev.00004.2008","article-title":"Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?","volume":"88","author":"Wallace","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2023.115086_b1710","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0016-5085(89)80056-3","article-title":"Aspirin-induced gastric mucosal injury: lessons learned from animal models","volume":"96","author":"Kauffman","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1715","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000201260","article-title":"Indomethacin interferes with epidermal growth factor binding and proliferative response of gastric KATO III cells","volume":"56","author":"Fujiwara","year":"1995","journal-title":"Digestion"},{"key":"10.1016\/j.addr.2023.115086_b1720","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0016-5085(70)80031-2","article-title":"Gastric mucosal blood flow following damage by ethanol, acetic acid, or aspirin","volume":"58","author":"Augur","year":"1970","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1725","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/0016-5085(87)90444-6","article-title":"Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation","volume":"93","author":"Kitahora","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2023.115086_b1730","doi-asserted-by":"crossref","unstructured":"J.L. Wallace, G.W. McKnight, The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin, Gastroenterology, 99 (1990) 295-304.","DOI":"10.1016\/0016-5085(90)91009-U"},{"key":"10.1016\/j.addr.2023.115086_b1735","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-9560-2-1","article-title":"The antithrombotic profile of aspirin. Aspirin resistance, or simply failure?","volume":"2","author":"Altman","year":"2004","journal-title":"Thromb. J."},{"key":"10.1016\/j.addr.2023.115086_b1740","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10555-017-9675-z","article-title":"Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention","volume":"36","author":"Ornelas","year":"2017","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.addr.2023.115086_b1745","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1073\/pnas.90.24.11693","article-title":"Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase","volume":"90","author":"Mitchell","year":"1993","journal-title":"PNAS"},{"key":"10.1016\/j.addr.2023.115086_b1750","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1073\/pnas.1933204100","article-title":"interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa","volume":"100","author":"Fiorucci","year":"2003","journal-title":"PNAS"},{"key":"10.1016\/j.addr.2023.115086_b1755","first-page":"672","article-title":"Inhibition of polymorphonuclear leukocyte adherence by prostacyclin","volume":"95","author":"Boxer","year":"1980","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.addr.2023.115086_b1760","doi-asserted-by":"crossref","first-page":"JC4","DOI":"10.7326\/ACPJ202101190-004","article-title":"Daily aspirin for primary prevention increased risk for major GI bleeding in healthy older adults","volume":"174","author":"Hirsch","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.addr.2023.115086_b1765","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.STR.16.1.1","article-title":"Progress review: the relationship between dose of aspirin, side-effects and antithrombotic effectiveness","volume":"16","author":"Hirsh","year":"1985","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2023.115086_b1770","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1365-2036.1997.00247.x","article-title":"Aspirin causes rapid up-regulation of cyclo-oxygenase-2 expression in the stomach of rats","volume":"11","author":"Davies","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.addr.2023.115086_b1775","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12024-009-9127-3","article-title":"Death of a toddler due to ingestion of sulfuric acid at a clandestine home methamphetamine laboratory","volume":"5","author":"Burge","year":"2009","journal-title":"Forensic Sci. Med. Pathol."},{"key":"10.1016\/j.addr.2023.115086_b1780","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/gut.2.2.110","article-title":"the turnover and shedding of epithelial cells. I. the turnover in the gastro-intestinal tract","volume":"2","author":"Creamer","year":"1961","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1785","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1152\/physrev.1956.36.2.255","article-title":"Renewal of cell populations","volume":"36","author":"Leblond","year":"1956","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.addr.2023.115086_b1790","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/pharmaceutics11070339","article-title":"Transmucosal absorption enhancers in the drug delivery field","volume":"11","author":"Maher","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2023.115086_b1795","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1111\/j.1572-0241.1999.01444.x","article-title":"intestinal permeability test as a predictor of clinical course in crohn's disease","volume":"94","author":"D'Inc\u00e0","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1800","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.addr.2023.115086_b1805","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.addr.2023.115086_b1810","first-page":"641","article-title":"Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications, expert rev","volume":"12","author":"Ponziani","year":"2018","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2023.115086_b1815","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.crohns.2013.01.004","article-title":"Hypothesis: Increased consumption of emulsifiers as an explanation for the rising incidence of crohn's disease","volume":"7","author":"Roberts","year":"2013","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.addr.2023.115086_b1820","doi-asserted-by":"crossref","first-page":"G851","DOI":"10.1152\/ajpgi.2000.279.5.G851","article-title":"Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells","volume":"279","author":"Nusrat","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2023.115086_b1825","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.nu.15.070195.000343","article-title":"Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium","volume":"15","author":"Ballard","year":"1995","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.addr.2023.115086_b1830","first-page":"G965","article-title":"Ethanol modulation of intestinal epithelial tight junction barrier","volume":"276","author":"Ma","year":"1999","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.addr.2023.115086_b1835","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1014053306343","article-title":"Effects of capsaicin on human intestinal cell line Caco-2","volume":"36","author":"Isoda","year":"2001","journal-title":"Cytotechnology"},{"key":"10.1016\/j.addr.2023.115086_b1840","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","article-title":"Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines","volume":"41","author":"Drago","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.addr.2023.115086_b1845","doi-asserted-by":"crossref","DOI":"10.3390\/nu9050500","article-title":"Macronutrient intake and risk of crohn's disease: systematic review and dose-response meta-analysis of epidemiological studies","volume":"9","author":"Zeng","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2023.115086_b1850","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fshw.2019.04.001","article-title":"Who will carry out the tests that would be necessary for proper safety evaluation of food emulsifiers?","volume":"8","author":"Cs\u00e1ki","year":"2019","journal-title":"Food Sci. Human Wellness"},{"key":"10.1016\/j.addr.2023.115086_b1855","first-page":"e06585","article-title":"Safety assessment of titanium dioxide (E171) as a food additive","volume":"19","author":"Younes","year":"2021","journal-title":"EFSA J."},{"key":"10.1016\/j.addr.2023.115086_b1860","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2018.08.032","article-title":"Oral peptide delivery: Translational challenges due to physiological effects","volume":"287","author":"Tyagi","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2023.115086_b1865","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/jps.24365","article-title":"animal farm: Considerations in animal gastrointestinal physiology and relevance to drug delivery in humans","volume":"104","author":"Hatton","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1870","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/bdd.2510160502","article-title":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals","volume":"16","author":"Kararli","year":"1995","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.addr.2023.115086_b1875","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2023.115086_b1880","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejps.2014.09.004","article-title":"Interactions between active pharmaceutical ingredients and excipients affecting bioavailability: Impact on bioequivalence","volume":"65","author":"Garc\u00eda-Arieta","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2023.115086_b1885","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jps.24643","article-title":"Effect of common excipients on the oral drug absorption of biopharmaceutics classification system Class 3 drugs cimetidine and acyclovir","volume":"105","author":"Vaithianathan","year":"2016","journal-title":"J. Pharm. Sci."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X23004015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X23004015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:35:43Z","timestamp":1759210543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X23004015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":378,"alternative-id":["S0169409X23004015"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2023.115086","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of surfactant excipients in oral drug formulations","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2023.115086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115086"}}