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Mesgari-Abbasi, TGF-\u03b21 receptor blockade attenuates unilateral ureteral obstruction-induced renal fibrosis in C57BL\/6 mice through attenuating Smad and MAPK pathways J Mol Histol 53 2022 691 698.","DOI":"10.1007\/s10735-022-10078-6"},{"key":"10.1016\/j.addr.2024.115317_b1065","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3892\/ijmm.2020.4594","article-title":"Promotion of liver regeneration and anti-fibrotic effects of the TGF-\u03b2 receptor kinase inhibitor galunisertib in CCl4-treated mice","volume":"46","author":"Masuda","year":"2020","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.addr.2024.115317_b1070","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s00204-018-2231-y","article-title":"Galunisertib modifies the liver fibrotic composition in the Abcb4Ko mouse model","volume":"92","author":"Hammad","year":"2018","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.addr.2024.115317_b1075","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/jpm12111812","article-title":"Therapeutic effect of polymeric nanomicelles formulation of LY2157299-Galunisertib on CCl4-induced liver fibrosis in rats","volume":"12","author":"Panzarini","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.addr.2024.115317_b1080","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.7150\/thno.52102","article-title":"Inhibition of TGF\u03b21 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2024.115317_b1085","doi-asserted-by":"crossref","first-page":"40491","DOI":"10.1021\/acsami.2c05352","article-title":"Galunisertib-loaded gelatin methacryloyl hydrogel microneedle patch for cardiac repair after myocardial infarction","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. 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