{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:27:00Z","timestamp":1792895220586,"version":"4.5.0"},"reference-count":316,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","award":["2022-CF-EMCR-004-25,314"],"award-info":[{"award-number":["2022-CF-EMCR-004-25,314"]}],"id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.addr.2025.115720","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:12:34Z","timestamp":1760512354000},"page":"115720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Microbiome-active drug delivery systems (MADDS): Leveraging microbial stimuli for controlled drug release"],"prefix":"10.1016","volume":"227","author":[{"given":"Srinivas","family":"Kamath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Ariaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer","family":"Abdelhafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarnab","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.addr.2025.115720_bb0005","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb0010","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1080\/17425247.2023.2233900","article-title":"Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery","volume":"20","author":"Kamath","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"issue":"7402","key":"10.1016\/j.addr.2025.115720_bb0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Microbiome Project, Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115720_bb0020","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2025-335077","article-title":"Translational strategies for oral delivery of faecal microbiota transplantation","author":"Kamath","year":"2025","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.addr.2025.115720_bb0025","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-023-01619-w","article-title":"Drug-microbiota interactions: an emerging priority for precision medicine","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.addr.2025.115720_bb0030","article-title":"Gut microbiome interactions with drug metabolism, efficacy and toxicity","volume":"179","author":"Wilson","year":"2016","journal-title":"Translational research : the journal of laboratory and clinical medicine"},{"issue":"Suppl. 4","key":"10.1016\/j.addr.2025.115720_bb0035","first-page":"8","article-title":"Spatial and temporal variability of the human microbiota","volume":"18","author":"Parfrey","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.addr.2025.115720_bb0040","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101986R","article-title":"Pharmacomicrobiomics: influence of gut microbiota on drug and xenobiotic metabolism","volume":"36","author":"Dikeocha","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.addr.2025.115720_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ph14121211","article-title":"Exploiting the metabolism of the gut microbiome as a vehicle for targeted drug delivery to the Colon","volume":"14","author":"Bakshi","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.addr.2025.115720_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103606","article-title":"Microbiota-sensitive drug delivery systems based on natural polysaccharides for colon targeting","volume":"28","author":"Azehaf","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2025.115720_bb0055","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.chembiol.2015.08.005","article-title":"Structure and inhibition of microbiome beta-Glucuronidases essential to the alleviation of Cancer drug toxicity","volume":"22","author":"Wallace","year":"2015","journal-title":"Chem. Biol."},{"key":"10.1016\/j.addr.2025.115720_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s40643-018-0206-8","article-title":"Azoreductase: a key player of xenobiotic metabolism","volume":"5","author":"Misal","year":"2018","journal-title":"Bioresour. Bioprocess."},{"key":"10.1016\/j.addr.2025.115720_bb0065","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/acs.molpharmaceut.6b01155","article-title":"Impact of gut microbiota-mediated bile acid metabolism on the Solubilization capacity of bile salt micelles and drug solubility","volume":"14","author":"Enright","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1124\/dmd.122.000898","article-title":"Gut microbiome-wide search for bacterial Azoreductases reveals potentially uncharacterized Azoreductases encoded in the human gut microbiome","volume":"51","author":"Braccia","year":"2023","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.addr.2025.115720_bb0075","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/s41598-018-36069-w","article-title":"Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases","volume":"9","author":"Biernat","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115720_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.07.001","article-title":"The role of gut microbial \u03b2-glucuronidase in drug disposition and development","volume":"27","author":"Gao","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2025.115720_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.07.001","article-title":"The role of gut microbial beta-glucuronidase in drug disposition and development","volume":"27","author":"Gao","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2025.115720_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fsysb.2022.951403","article-title":"A complete guide to human microbiomes: body niches, transmission, development, dysbiosis, and restoration","volume":"2","author":"Reynoso-Garcia","year":"2022","journal-title":"Front Syst Biol"},{"key":"10.1016\/j.addr.2025.115720_bb0095","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/1462-2920.13659","article-title":"Microbial nutrient niches in the gut","volume":"19","author":"Pereira","year":"2017","journal-title":"Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.addr.2025.115720_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.addr.2025.115720_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.657986","article-title":"The origin of niches and species in the bacterial world","volume":"12","author":"Baquero","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0110","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/jam.15640","article-title":"Nanocarriers for combating biofilms: advantages and challenges","volume":"133","author":"Zhang","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0115","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.7150\/thno.67296","article-title":"Recent advances in nanotechnology for eradicating bacterial biofilm","volume":"12","author":"Sahli","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2025.115720_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fbiom.2022.916985","article-title":"Controlled release of therapeutics from enzyme-responsive biomaterials","volume":"1","author":"Minehan","year":"2022","journal-title":"Frontiers in Biomaterials Science"},{"key":"10.1016\/j.addr.2025.115720_bb0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12934-022-01799-0","article-title":"Engineered probiotics","volume":"21","author":"Ma","year":"2022","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.addr.2025.115720_bb0130","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1521-6918(03)00072-6","article-title":"Genetically engineered probiotics","volume":"17","author":"Steidler","year":"2003","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115720_bb0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.copbio.2020.02.016","article-title":"Engineering probiotics for therapeutic applications: recent examples and translational outlook","volume":"65","author":"Aggarwal","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084421","article-title":"Enzyme-responsive hydrogels as potential drug delivery systems-state of knowledge and future prospects","volume":"23","author":"Sobczak","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0145","doi-asserted-by":"crossref","first-page":"1272754","DOI":"10.3389\/fmicb.2023.1272754","article-title":"Comparing technology and regulatory landscape of probiotics as food, dietary supplements and live biotherapeutics","volume":"14","author":"Spacova","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phanu.2024.100423","article-title":"A comprehensive review of probiotic claims regulations: updates from Asia-Pacific, United States, and Europe","volume":"30","author":"Garg","year":"2024","journal-title":"Pharmanutrition"},{"key":"10.1016\/j.addr.2025.115720_bb0155","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s41565-024-01754-7","article-title":"A translational framework to DELIVER nanomedicines to the clinic","volume":"19","author":"Joyce","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260433","article-title":"Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: a study protocol","volume":"16","author":"Nath","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115720_bb0165","article-title":"Resilience of the oral microbiome","volume":"86","author":"Wade","year":"2000","journal-title":"Periodontology"},{"issue":"86","key":"10.1016\/j.addr.2025.115720_bb0170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/prd.12365","article-title":"Resilience of the oral microbiome","volume":"2000","author":"Wade","year":"2021","journal-title":"Periodontol"},{"key":"10.1016\/j.addr.2025.115720_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3934\/microbiol.2018.1.42","article-title":"Oral microbiome and health","volume":"4","author":"Sharma","year":"2018","journal-title":"AIMS Microbiol"},{"key":"10.1016\/j.addr.2025.115720_bb0180","first-page":"1335","article-title":"The oralome and its dysbiosis: new insights into oral microbiome-host interactions, Comput Struct","volume":"19","author":"Radaic","year":"2021","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.addr.2025.115720_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11050217","article-title":"Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities","volume":"11","author":"Leyva-Gomez","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115720_bb0190","doi-asserted-by":"crossref","first-page":"S296","DOI":"10.1093\/infdis\/jiaa676","article-title":"Connecting the dots: translating the vaginal microbiome into a drug","volume":"223","author":"Lagenaur","year":"2021","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.addr.2025.115720_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108732","article-title":"Interactions between microbiome and lungs: paving new paths for microbiome based bio-engineered drug delivery systems in chronic respiratory diseases","volume":"310","author":"Chellappan","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.addr.2025.115720_bb0200","doi-asserted-by":"crossref","first-page":"98","DOI":"10.12788\/j.sder.0087","article-title":"The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease","volume":"33","author":"Grice","year":"2014","journal-title":"Semin. Cutan. Med. Surg."},{"key":"10.1016\/j.addr.2025.115720_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11092307","article-title":"Oral microbiota: the influences and interactions of saliva, IgA, and dietary factors in health and disease","volume":"11","author":"Nagakubo","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb0210","doi-asserted-by":"crossref","first-page":"1723975","DOI":"10.1080\/20002297.2020.1723975","article-title":"The salivary microbiota in health and disease","volume":"12","author":"Belstrom","year":"2020","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/jphp.12313","article-title":"Mucoadhesive polymers-based film as a carrier system for sublingual delivery of glutathione","volume":"67","author":"Chen","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.addr.2025.115720_bb0220","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.2147\/CCID.S378470","article-title":"Augmented glutathione absorption from Oral mucosa and its effect on skin pigmentation: a clinical review","volume":"15","author":"Sharma","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.addr.2025.115720_bb0225","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5056\/jnm19240","article-title":"Exploring esophageal microbiomes in esophageal diseases: a systematic review","volume":"26","author":"Park","year":"2020","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.addr.2025.115720_bb0230","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11938-018-0171-5","article-title":"Emerging insights into the esophageal microbiome","volume":"16","author":"May","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"10.1016\/j.addr.2025.115720_bb0235","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cophys.2021.04.003","article-title":"Interactions between H. pylori and the gastric microbiome: impact on gastric homeostasis and disease","volume":"21","author":"Serrano","year":"2021","journal-title":"Curr. Opin. Physio."},{"key":"10.1016\/j.addr.2025.115720_bb0240","first-page":"255","article-title":"The human gastric microbiota: is it time to rethink the pathogenesis of stomach diseases?, united European","volume":"3","author":"Nardone","year":"2015","journal-title":"Gastroenterol. J."},{"key":"10.1016\/j.addr.2025.115720_bb0245","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1080\/17425247.2023.2223937","article-title":"The impact of common pharmaceutical excipients on the gut microbiota","volume":"20","author":"Subramaniam","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2025.115720_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17425255.2024.2407616","article-title":"A critical need for 'gut neutrality': mitigating adverse drug-microbiome interactions","volume":"21","author":"Kamath","year":"2025","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.addr.2025.115720_bb0255","first-page":"432","article-title":"Pharmacomicrobiomics: a novel route towards personalized medicine?, protein","volume":"9","author":"Doestzada","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115720_bb0260","first-page":"33","article-title":"The structure and function of the human small intestinal microbiota: current understanding and future directions, cell Mol","volume":"9","author":"Kastl","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115720_bb0265","doi-asserted-by":"crossref","first-page":"19929","DOI":"10.1038\/s41598-021-99379-6","article-title":"Comparing the gut microbiome along the gastrointestinal tract of three sympatric species of wild rodents","volume":"11","author":"Anders","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115720_bb0270","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/1471-0528.14390","article-title":"Why do lactobacilli dominate the human vaginal microbiota?","volume":"124","author":"Witkin","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.addr.2025.115720_bb0275","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12941-020-0347-4","article-title":"Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review","volume":"19","author":"Kalia","year":"2020","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.addr.2025.115720_bb0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12934-020-01464-4","article-title":"Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health","volume":"19","author":"Chee","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.addr.2025.115720_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2025.114831","article-title":"Advancements in drug delivery systems for women's reproductive health: vaginal microbiome as a target for innovative drug delivery systems","volume":"215","author":"Bassey","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2025.115720_bb0290","doi-asserted-by":"crossref","first-page":"1005537","DOI":"10.3389\/fonc.2022.1005537","article-title":"Increased diversity of a cervical microbiome associates with cervical cancer","volume":"12","author":"Zeber-Lubecka","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.addr.2025.115720_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010222","article-title":"The role of the Cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical Cancer","volume":"21","author":"Curty","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0300","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1208\/s12248-017-0054-z","article-title":"Challenges and future prospects for the delivery of biologics: Oral mucosal, pulmonary, and transdermal routes","volume":"19","author":"Morales","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.addr.2025.115720_bb0305","doi-asserted-by":"crossref","first-page":"2470379","DOI":"10.1080\/09546634.2025.2470379","article-title":"The effects of topical antimicrobial-corticosteroid combination therapy in comparison to topical steroids alone on the skin microbiome of patients with atopic dermatitis","volume":"36","author":"Tingting","year":"2025","journal-title":"J. Dermatolog. Treat."},{"key":"10.1016\/j.addr.2025.115720_bb0310","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02945-19","article-title":"Universal Dermal Microbiome in Human Skin","volume":"11","author":"Bay","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.addr.2025.115720_bb0315","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41522-020-0130-5","article-title":"Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds","volume":"6","author":"Verbanic","year":"2020","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb0320","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1089\/wound.2012.0397","article-title":"The wound microbiome: modern approaches to examining the role of microorganisms in impaired chronic wound healing","volume":"3","author":"Misic","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.addr.2025.115720_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094629","article-title":"Host-microbiome crosstalk in chronic wound healing","volume":"25","author":"Mihai","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15102426","article-title":"Matrix-mediated delivery of silver nanoparticles for prevention of Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation in chronic rhinosinusitis","volume":"15","author":"Yathavan","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115720_bb0335","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.cell.2025.01.017","article-title":"Engineered commensals for targeted nose-to-brain drug delivery","volume":"188","author":"Shen","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115720_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10071405","article-title":"Nasal microbiota, olfactory health, neurological disorders and aging-a review","volume":"10","author":"Thangaleela","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb0345","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.tins.2022.08.003","article-title":"The microbiome-nose-brain axis in health and disease","volume":"45","author":"Lazarini","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.addr.2025.115720_bb0350","doi-asserted-by":"crossref","DOI":"10.1177\/2152656720911605","article-title":"The microbiome of the nose-friend or foe?","volume":"11","author":"Dimitri-Pinheiro","year":"2020","journal-title":"Allergy Rhinol (Providence)"},{"key":"10.1016\/j.addr.2025.115720_bb0355","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fped.2019.00393","article-title":"Lower airway microbiota","volume":"7","author":"Pulvirenti","year":"2019","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.addr.2025.115720_bb0360","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41392-023-01722-y","article-title":"Lung microbiome: new insights into the pathogenesis of respiratory diseases","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115720_bb0365","doi-asserted-by":"crossref","first-page":"8361","DOI":"10.1038\/s41467-024-52713-8","article-title":"Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illness","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb0370","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40413-015-0074-z","article-title":"The microbiome of the human lower airways: a next generation sequencing perspective","volume":"8","author":"Aho","year":"2015","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.addr.2025.115720_bb0375","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11884-016-0345-8","article-title":"The bladder is not sterile: history and current discoveries on the urinary microbiome","volume":"11","author":"Thomas-White","year":"2016","journal-title":"Curr. Bladder Dysfunct. Rep."},{"key":"10.1016\/j.addr.2025.115720_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127010","article-title":"The urinary microbiome and biological therapeutics: novel therapies for urinary tract infections","volume":"259","author":"Kenneally","year":"2022","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb0385","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8071033","article-title":"Current evidence on the ocular surface microbiota and related diseases","volume":"8","author":"Petrillo","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb0390","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/ICL.0000000000001077","article-title":"The conjunctival microbiome and dry eye: what we know and controversies","volume":"50","author":"Shih","year":"2024","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.addr.2025.115720_bb0395","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/APO.0000000000000330","article-title":"Ocular surface microbiome in health and disease","volume":"9","author":"Gomes","year":"2020","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"10.1016\/j.addr.2025.115720_bb0400","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1097\/MAO.0000000000003031","article-title":"Microbiome of the healthy external Auditory Canal","volume":"42","author":"Sjovall","year":"2021","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.addr.2025.115720_bb0405","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5021\/ad.22.153","article-title":"Analysis of the microbiome of the ear canal in Normal individuals and patients with chronic otitis externa","volume":"34","author":"Lee","year":"2022","journal-title":"Ann. Dermatol."},{"key":"10.1016\/j.addr.2025.115720_bb0410","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262806","article-title":"The adult microbiome of healthy and otitis patients: definition of the core healthy and diseased ear microbiomes","volume":"17","author":"Burton","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115720_bb0415","doi-asserted-by":"crossref","first-page":"goab046","DOI":"10.1093\/gastro\/goab046","article-title":"Microbiome therapeutics: exploring the present scenario and challenges","volume":"10","author":"Yadav","year":"2022","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.addr.2025.115720_bb0420","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2049-2618-1-24","article-title":"Opportunities and challenges for gut microbiome studies in the Indian population","volume":"1","author":"Shetty","year":"2013","journal-title":"Microbiome"},{"key":"10.1016\/j.addr.2025.115720_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2016.04.032","article-title":"Microbiome therapeutics \u2013 advances and challenges","volume":"105","author":"Mimee","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb0430","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4161\/gmic.27915","article-title":"Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics","volume":"5","author":"Haiser","year":"2014","journal-title":"Gut Microbes"},{"key":"10.1016\/j.addr.2025.115720_bb0435","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/19490976.2015.1024918","article-title":"Type 2 diabetes and gut microbiome: at the intersection of known and unknown","volume":"6","author":"Upadhyaya","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.addr.2025.115720_bb0440","doi-asserted-by":"crossref","DOI":"10.1111\/apm.13225","article-title":"The human microbiome in disease and pathology","volume":"130","author":"Manos","year":"2022","journal-title":"Apmis"},{"key":"10.1016\/j.addr.2025.115720_bb0445","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073464","article-title":"Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets","volume":"23","author":"Santana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2015.10.005","article-title":"Dysbiotic gut microbiome: a key element of Crohn's disease","volume":"43","author":"\u00d8yri","year":"2015","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.addr.2025.115720_bb0455","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3389\/fmicb.2016.01936","article-title":"Lactobacilli dominance and vaginal pH: why is the human vaginal microbiome unique?","volume":"7","author":"Miller","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0460","doi-asserted-by":"crossref","first-page":"1153894","DOI":"10.3389\/fcimb.2023.1153894","article-title":"Use of probiotic lactobacilli in the treatment of vaginal infections: in vitro and in vivo investigations","volume":"13","author":"Liu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0465","article-title":"The female vaginal microbiome in health and bacterial vaginosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.addr.2025.115720_bb0470","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-023-01072-w","article-title":"The updates and implications of cutaneous microbiota in acne","volume":"13","author":"Huang","year":"2023","journal-title":"Cell & Bioscience"},{"key":"10.1016\/j.addr.2025.115720_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120347","article-title":"Application of inulin\/Eudragit RS in 5-ASA pellet coating with tuned, sustained-release feature in an animal model of ulcerative colitis","volume":"597","author":"Shahdadi Sardou","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0480","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/s12951-024-02724-w","article-title":"Sustained release of 5-aminosalicylic acid from azoreductase-responsive polymeric prodrugs for prolonged colon-targeted colitis therapy","volume":"22","author":"Tang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb0485","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1039\/C5TB02054A","article-title":"Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms","volume":"4","author":"Zhou","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.addr.2025.115720_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401289","article-title":"Redox-responsive hydrogels loaded with an antibacterial peptide as controlled drug delivery for healing infectious wounds","volume":"13","author":"Cherri","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.addr.2025.115720_bb0495","article-title":"Reactive oxygen species sensitive nanomicelles promote the antifungal activity of ketoconazole against Candida albicans in vulvovaginal candidiasis - PubMed","volume":"243","author":"H. Y, P. H, W. R, X. J, C. M, W. Y, S. B","year":"2024","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.addr.2025.115720_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/S0378-5173(02)00172-2","article-title":"5-fluorouracil encapsulated alginate beads for the treatment of breast cancer","volume":"242","author":"Ar\u0131ca","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0505","doi-asserted-by":"crossref","DOI":"10.1021\/acsnano.2c04232","article-title":"Designer Liposomic Nanocarriers are effective biofilm eradicators","volume":"16","author":"Kluzek","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115720_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105960","article-title":"Antibacterial, antifungal, and anti-biofilm effects of sulfamethoxazole-complexes against pulmonary infection agents","volume":"175","author":"Siqueira","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.addr.2025.115720_bb0515","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1039\/C8NR05784B","article-title":"Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery","volume":"11","author":"Sims","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2025.115720_bb0520","doi-asserted-by":"crossref","DOI":"10.1021\/jacs.4c12945","article-title":"Selective biofilm inhibition through mucin-inspired engineering of silk Glycopolymers","volume":"146","author":"Werlang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.addr.2025.115720_bb0525","article-title":"Engineered probiotic for the inhibition of Salmonella via Tetrathionate-induced production of Microcin H47","volume":"4","author":"Palmer","year":"2017","journal-title":"ACS infectious diseases"},{"key":"10.1016\/j.addr.2025.115720_bb0530","article-title":"Engineered vaginal lactobacillus strain for mucosal delivery of the human immunodeficiency virus inhibitor cyanovirin-N - PubMed","volume":"50","author":"L. X, L. LA, S. DA, E. KP, F.-P. CL, L. Y, T. D, R. SS, H. DH, P. TP, L. PP, X. Q","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.addr.2025.115720_bb0535","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.chom.2024.09.004","article-title":"Rapid design of bacteriophage cocktails to suppress the burden and virulence of gut-resident carbapenem-resistant Klebsiella pneumoniae","volume":"32","author":"Rotman","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2025.115720_bb0540","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/mmi.12697","article-title":"Biofilm formation by Bacillus subtilis: new insights into regulatory strategies and assembly mechanisms","volume":"93","author":"Cairns","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0545","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1039\/C7SC00472A","article-title":"Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers","volume":"8","author":"Renoux","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0550","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.1038\/npjbiofilms.2016.3","article-title":"The gut microbiota: a major player in the toxicity of environmental pollutants?","volume":"2","author":"Claus","year":"2016","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/biom14121638","article-title":"Enzymatic regulation of the gut microbiota: mechanisms and implications for host health","volume":"14","author":"Jiang","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.addr.2025.115720_bb0560","first-page":"390","article-title":"Toxicomicrobiomics: the human microbiome vs","volume":"11","author":"Abdelsalam","year":"2020","journal-title":"Pharmaceutical, Dietary, and Environmental Xenobiotics, Front Pharmacol"},{"key":"10.1016\/j.addr.2025.115720_bb0565","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-12-S7-A10","article-title":"PharmacoMicrobiomics or how bugs modulate drugs: an educational initiative to explore the effects of human microbiome on drugs","volume":"12","author":"Aziz","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.addr.2025.115720_bb0570","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00253-024-13016-6","article-title":"Xanthan: enzymatic degradation and novel perspectives of applications","volume":"108","author":"Berezina","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb0575","article-title":"Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites","volume":"8","author":"Kedir","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.addr.2025.115720_bb0580","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1002\/jps.24103","article-title":"On the colonic bacterial metabolism of azo-bonded prodrugsof 5-aminosalicylic acid","volume":"103","author":"Sousa","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0585","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1586\/ecp.12.2","article-title":"Mesalamine in the treatment and maintenance of remission of ulcerative colitis","volume":"5","author":"Ham","year":"2012","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2025.115720_bb0590","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-020-00057-7","article-title":"Recent advances in mesalamine colonic delivery systems","volume":"6","author":"Bayan","year":"2020","journal-title":"Future Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.addr.2025.115720_bb0595","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00048.2011","article-title":"Functional analysis of colonic bacterial metabolism: relevant to health?","volume":"302","author":"Hamer","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.addr.2025.115720_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106115","article-title":"Inhibition of gut microbial beta-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis","volume":"177","author":"Cheng","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb0605","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0076-6879(05)00015-7","article-title":"Glucuronidase deconjugation in inflammation","volume":"400","author":"Shimoi","year":"2005","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.addr.2025.115720_bb0610","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00204-015-1593-7","article-title":"Inflammation-associated extracellular beta-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene","volume":"90","author":"Shi","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.addr.2025.115720_bb0615","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1007\/BF02220454","article-title":"Bacterial enzymes used for colon-specific drug delivery are decreased in active Crohn's disease","volume":"40","author":"Carrette","year":"1995","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0620","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.3390\/ijms25094834","article-title":"The Role of Prebiotics in Modulating Gut Microbiota: Implications for Human Health","volume":"25","author":"Yoo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0625","first-page":"10","article-title":"Probiotics and prebiotics in intestinal health and disease: from biology to the clinic","volume":"16","author":"Sanders","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115720_bb0630","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094834","article-title":"The role of prebiotics in modulating gut microbiota: implications for human health","volume":"25","author":"Yoo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0635","series-title":"The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review - PubMed, Advances in nutrition (Bethesda, Md.)","volume":"13","author":"Rl","year":"2022"},{"key":"10.1016\/j.addr.2025.115720_bb0640","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10096-019-03721-w","article-title":"The effects of inulin on gut microbial composition: a systematic review of evidence from human studies","volume":"39","author":"Le Bastard","year":"2020","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.addr.2025.115720_bb0645","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/advances\/nmab119","article-title":"The prebiotic potential of inulin-type Fructans: a systematic review","volume":"13","author":"Hughes","year":"2022","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.addr.2025.115720_bb0650","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: the international scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115720_bb0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.129131","article-title":"Inulin: unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics","volume":"259","author":"Akram","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115720_bb0660","first-page":"855","volume":"14","author":"Afinjuomo","year":"2021","journal-title":"Inulin and Its Application in Drug Delivery, Pharmaceuticals"},{"key":"10.1016\/j.addr.2025.115720_bb0665","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.carbpol.2015.08.022","article-title":"Inulin, a flexible oligosaccharide. II: review of its pharmaceutical applications","volume":"134","author":"Mensink","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115720_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119861","article-title":"Combination of inulin and beta-cyclodextrin properties for colon delivery of hydrophobic drugs","volume":"589","author":"Catenacci","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0675","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.2147\/IJN.S390102","article-title":"Advancement in therapeutic intervention of prebiotic-based nanoparticles for colonic diseases","volume":"17","author":"Ren","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115720_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2021.102532","article-title":"Colorectal cancer: a comprehensive review based on the novel drug delivery systems approach and its management","volume":"63","author":"Hani","year":"2021","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.addr.2025.115720_bb0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120074","article-title":"Recent advances in oral delivery of bioactive molecules: focus on prebiotic carbohydrates as vehicle matrices","volume":"298","author":"Falsafi","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115720_bb0690","doi-asserted-by":"crossref","first-page":"2003542","DOI":"10.1002\/advs.202003542","article-title":"Gut microbiota: influence on carcinogenesis and modulation strategies by drug delivery systems to improve Cancer therapy","volume":"8","author":"Zhu","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.addr.2025.115720_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-816808-0.00008-1","article-title":"Pectin as oral colon-specific nano- and microparticulate drug carriers","author":"Zainudin","year":"2020","journal-title":"Polymer Science and Innovative Applications"},{"key":"10.1016\/j.addr.2025.115720_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2021.04.009","article-title":"Applying probiotics and prebiotics in new delivery formats \u2013 is the clinical evidence transferable?","volume":"112","author":"Cunningham","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.addr.2025.115720_bb0705","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118530","article-title":"Colon-targeted drug delivery of polysaccharide-based nanocarriers for synergistic treatment of inflammatory bowel disease: a review","volume":"272","author":"Cui","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115720_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125873","article-title":"Synbiotic formulations with microbial biofilm, animal derived (casein, collagen, chitosan) and plant derived (starch, cellulose, alginate) prebiotic polymers: a review","volume":"248","author":"Chauhan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115720_bb0715","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/gt.2008.67","article-title":"Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease","volume":"15","author":"Bhavsar","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.addr.2025.115720_bb0720","doi-asserted-by":"crossref","first-page":"2403914","DOI":"10.1002\/adfm.202403914","article-title":"Inulin-Lipid Core\u2013Shell Microcapsules Target the Gut Microbiota and Mimic the Pharmaceutical Food Effect for Improved Oral Antipsychotic Delivery","volume":"34","author":"Meola","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.addr.2025.115720_bb0725","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2016.08.002","article-title":"Gut microbiome interactions with drug metabolism, efficacy, and toxicity","volume":"179","author":"Wilson","year":"2017","journal-title":"Transl. Res."},{"key":"10.1016\/j.addr.2025.115720_bb0730","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41467-024-48661-y","article-title":"Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy","volume":"15","author":"Shen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb0735","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/17512433.2018.1414598","article-title":"The role of gut microbiota in the modulation of drug action: a focus on some clinically significant issues","volume":"11","author":"Curro","year":"2018","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.addr.2025.115720_bb0740","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41591-023-02217-7","article-title":"Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease","volume":"29","author":"Mehta","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115720_bb0745","article-title":"The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis","volume":"5","author":"Lima","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.addr.2025.115720_bb0750","volume":"28","author":"Dang","year":"2025","journal-title":"Gut microbiome signatures predict 5-ASA efficacy in ulcerative colitis, iScience"},{"key":"10.1016\/j.addr.2025.115720_bb0755","article-title":"Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals - PubMed","volume":"19","author":"B. S, S. TV, D. J, K. J, P. R","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.addr.2025.115720_bb0760","doi-asserted-by":"crossref","DOI":"10.1016\/j.cdev.2021.203712","article-title":"At the right time in the right place: how do luminal gradients position the microbiota along the gut?","volume":"168","author":"Chikina","year":"2021","journal-title":"Cells & Development"},{"key":"10.1016\/j.addr.2025.115720_bb0765","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005364","article-title":"Two dynamic regimes in the human gut microbiome","volume":"13","author":"Gibbons","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.addr.2025.115720_bb0770","article-title":"Metabolism characteristics of lactic acid Bacteria and the expanding applications in food industry","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb0775","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/19490976.2017.1290756","article-title":"Dietary fiber and prebiotics and the gastrointestinal microbiota","volume":"8","author":"Holscher","year":"2017","journal-title":"Gut Microbes"},{"key":"10.1016\/j.addr.2025.115720_bb0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105420","article-title":"The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis","volume":"165","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb0785","article-title":"Vaginal pH and Microbicidal lactic acid when lactobacilli dominate the microbiota","volume":"8","author":"O'Hanlon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115720_bb0790","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129664","article-title":"Multi-omics study of sulfur metabolism affecting functional microbial community succession during aerobic solid-state fermentation","volume":"387","author":"Zhang","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.addr.2025.115720_bb0795","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijpharm.2019.01.022","article-title":"A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems","volume":"558","author":"Shahdadi Sardo","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0800","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3109\/10717544.2014.940091","article-title":"Stimuli-responsive hydrogels in drug delivery and tissue engineering","volume":"23","author":"Sood","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2025.115720_bb0805","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/pharmaceutics17020226","article-title":"pH-dependent drug delivery Systems for Ulcerative Colitis Treatment","volume":"17","author":"Gvozdeva","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115720_bb0810","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.drudis.2020.06.011","article-title":"pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems","volume":"25","author":"Broesder","year":"2020","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2025.115720_bb0815","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.705583","article-title":"The capacity to produce hydrogen sulfide (H2S) via cysteine degradation is ubiquitous in the human gut microbiome","volume":"12","author":"Braccia","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0820","first-page":"1260","article-title":"Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities, nature","volume":"4","author":"Wolfson","year":"2022","journal-title":"Metabolism"},{"key":"10.1016\/j.addr.2025.115720_bb0825","doi-asserted-by":"crossref","first-page":"eabp9960","DOI":"10.1126\/science.abp9960","article-title":"The microbiome and gut homeostasis","volume":"377","author":"Lee","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115720_bb0830","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1387903","article-title":"Gut redox and microbiome: charting the roadmap to T-cell regulation","volume":"15","author":"Prasad","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2025.115720_bb0835","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.carbpol.2017.12.021","article-title":"Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases","volume":"189","author":"Sun","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115720_bb0840","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/btm2.10014","article-title":"ROS-responsive drug delivery systems","volume":"1","author":"Liang","year":"2016","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.addr.2025.115720_bb0845","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.3390\/biomedicines11051388","article-title":"The influence of gut microbiota on oxidative stress and the immune system","volume":"11","author":"Kunst","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.addr.2025.115720_bb0850","first-page":"2403","article-title":"Oxidative stress and DNA damage: implications in inflammatory bowel disease","volume":"21","author":"Pereira","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.addr.2025.115720_bb0855","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1126579","article-title":"Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis","volume":"10","author":"Ashique","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.addr.2025.115720_bb0860","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12935-023-03095-2","article-title":"Microbiome modulation in inflammatory diseases: Progress to microbiome genetic engineering","volume":"23","author":"Mousavinasab","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.addr.2025.115720_bb0865","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiac038","article-title":"The impact of environmental pH on the gut microbiota community structure and short chain fatty acid production","volume":"98","author":"Firrman","year":"2022","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.addr.2025.115720_bb0870","article-title":"A dual pH and microbiota-triggered coating (Phloral\u2122) for fail-safe colonic drug release - PubMed","volume":"583","author":"V. F, F. AC, F. HM, B. R, B. AW","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb0875","article-title":"An oral pH-activated \"nano-bomb\" carrier combined with berberine by regulating gene silencing and gut microbiota for site-specific treatment of ulcerative colitis - PubMed","volume":"10","author":"Y. M, Y. C, Z. Y, Y. X, M. Y, Z. Y, C. Y, X. Q, T. K, Z. M","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0880","doi-asserted-by":"crossref","first-page":"1083330","DOI":"10.3389\/fmicb.2023.1083330","article-title":"Amoxicillin-docosahexaenoic acid encapsulated chitosan-alginate nanoparticles as a delivery system with enhanced biocidal activities against helicobacter pylori and improved ulcer healing","volume":"14","author":"Khoshnood","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb0885","doi-asserted-by":"crossref","DOI":"10.1021\/nn507170s","article-title":"pH-activated nanoparticles for controlled topical delivery of Farnesol to disrupt Oral biofilm virulence","volume":"9","author":"Horev","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115720_bb0890","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10856-018-6166-x","article-title":"In situ-forming and pH-responsive hydrogel based on chitosan for vaginal delivery of therapeutic agents","volume":"29","author":"Jalalvandi","year":"2018","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.addr.2025.115720_bb0895","article-title":"Whey protein\/polysaccharide-stabilized emulsions: effect of polymer type and pH on release and topical delivery of salicylic acid - PubMed","volume":"15","author":"C. J, O. A, d.P. J","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2025.115720_bb0900","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1038\/s41598-022-12431-x","article-title":"Mapping microbiome-redox spectrum and evaluating microbial-redox index in chronic gastritis","volume":"12","author":"Panigrahi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115720_bb0905","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3109\/10715762.2013.833331","article-title":"Redox signaling mediated by the gut microbiota","volume":"47","author":"Neish","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.addr.2025.115720_bb0910","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137340","article-title":"Regulation of gut microbiome with redox responsible bacterial cellulose hydrogel for precision chemo-radiotherapy of intestinal cancer","volume":"446","author":"Shi","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.addr.2025.115720_bb0915","doi-asserted-by":"crossref","first-page":"4535194","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.addr.2025.115720_bb0920","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/092986712799828283","article-title":"Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications","volume":"19","author":"Jones","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.addr.2025.115720_bb0925","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109737","article-title":"Mitochondria, the gut microbiome and ROS","volume":"75","author":"Ballard","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.addr.2025.115720_bb0930","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmat2859","article-title":"Orally delivered thioketal nanoparticles loaded with TNF-\u03b1\u2013siRNA target inflammation and inhibit gene expression in the intestines","volume":"9","author":"Wilson","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.addr.2025.115720_bb0935","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jconrel.2019.10.054","article-title":"A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease","volume":"316","author":"Li","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106856","article-title":"ROS-responsive thioketal nanoparticles delivering system for targeted ulcerative colitis therapy with potent HDAC6 inhibitor, tubastatin a","volume":"201","author":"Shrestha","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0945","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2019.11.001","article-title":"Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1\/Th17 differentiation","volume":"316","author":"Regmi","year":"2019","journal-title":"J. Control. Release"},{"issue":"15","key":"10.1016\/j.addr.2025.115720_bb0950","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1039\/D5MH00114E","article-title":"Reactive Oxygen Species-Responsive Prodrug Nanomicelle-Functionalized Lactobacillus rhamnosus Probiotics for Amplified Therapy of Ulcerative Colitis","volume":"12","author":"Zhang","year":"2025","journal-title":"Materials Horizons"},{"key":"10.1016\/j.addr.2025.115720_bb0955","first-page":"457","article-title":"Reactive oxygen species-scavenging hollow MnO2 nanozymes as carriers to deliver budesonide for synergistic inflammatory bowel disease therapy, biomaterials","volume":"10","author":"Qiu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115720_bb0960","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1039\/C6NR00791K","article-title":"Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications","volume":"8","author":"J\u00e4ger","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2025.115720_bb0965","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jconrel.2023.05.007","article-title":"Wielding the double-edged sword: redox drug delivery systems for inflammatory bowel disease","volume":"358","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb0970","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/ijms26020575","article-title":"Advancing inflammatory bowel disease treatment by targeting the innate immune system and precision drug delivery","volume":"26","author":"Kiilerich","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0975","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1039\/D4TB02868F","article-title":"Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery","volume":"13","author":"Wan","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.addr.2025.115720_bb0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2022.06.024","article-title":"ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment","volume":"148","author":"Muhammad","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2025.115720_bb0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135157","article-title":"Development of ROS-sensitive capofungin hydrogel by crosslinking chitosan with four-arm polyethylene glycol derivative for treatment of vulvovaginal candidiasis","volume":"279","author":"Pan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115720_bb0990","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tips.2019.04.006","article-title":"Deciphering the Chemical Lexicon of Host\u2013Gut Microbiota Interactions","volume":"40","author":"Nicolas","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb0995","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.4049\/jimmunol.2100528","article-title":"Small Molecule Metabolites at the Host\u2013Microbiota Interface","volume":"207","author":"Bishai","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.addr.2025.115720_bb1000","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mib.2013.07.002","article-title":"Colonic bacterial metabolites and human health","volume":"16","author":"Russell","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1005","doi-asserted-by":"crossref","first-page":"eaag2770","DOI":"10.1126\/science.aag2770","article-title":"Chemical transformation of xenobiotics by the human gut microbiota","volume":"356","author":"Koppel","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115720_bb1010","first-page":"136","article-title":"Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior","volume":"20","author":"Dumas","year":"2017","journal-title":"Obesity, and Impaired Glucose Tolerance, Cell Reports"},{"key":"10.1016\/j.addr.2025.115720_bb1015","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1038\/s41467-019-10927-1","article-title":"Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences","volume":"10","author":"Mallick","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb1020","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-micro-060221-012134","article-title":"Genome-scale metabolic modeling of the human microbiome in the era of personalized medicine","volume":"75","author":"Heinken","year":"2021","journal-title":"Ann. Rev. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1025","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201900319","article-title":"Biosensing in smart engineered probiotics","volume":"15","author":"Rottinghaus","year":"2020","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.addr.2025.115720_bb1030","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1021\/acssynbio.2c00314","article-title":"Intestinal engineered probiotics as living therapeutics: chassis selection, Colonization Enhancement, Gene Circuit Design, and Biocontainment","volume":"11","author":"Huang","year":"2022","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.addr.2025.115720_bb1035","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.chom.2022.12.004","article-title":"Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice","volume":"31","author":"Zou","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2025.115720_bb1040","article-title":"Engineered probiotic for the inhibition of Salmonella via Tetrathionate-induced production of Microcin H47, ACS","volume":"4","author":"Palmer","year":"2017","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.addr.2025.115720_bb1045","doi-asserted-by":"crossref","first-page":"923","DOI":"10.15252\/msb.20167416","article-title":"Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation","volume":"13","author":"Daeffler","year":"2017","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.addr.2025.115720_bb1050","doi-asserted-by":"crossref","DOI":"10.1016\/j.engmic.2024.100167","article-title":"Genetically engineered bacteria as inflammatory bowel disease therapeutics","volume":"4","author":"Zou","year":"2024","journal-title":"Eng Microbiol"},{"key":"10.1016\/j.addr.2025.115720_bb1055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13036-023-00379-z","article-title":"Engineered live bacteria as disease detection and diagnosis tools","volume":"17","author":"Tanniche","year":"2023","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.addr.2025.115720_bb1060","doi-asserted-by":"crossref","first-page":"1267378","DOI":"10.3389\/fbioe.2023.1267378","article-title":"Systems and synthetic biology-driven engineering of live bacterial therapeutics","volume":"11","author":"Kim","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb1065","doi-asserted-by":"crossref","first-page":"1088153","DOI":"10.3389\/fmicb.2022.1088153","article-title":"Hydrogen sulfide-sensitive chitosan-SS-levofloxacin micelles with a high drug content: facile synthesis and targeted Salmonella infection therapy","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1070","first-page":"1739","article-title":"Pneumolysin-responsive liposomal platform for selective treatment of Streptococcus pneumoniae, drug Deliv","volume":"15","author":"Watt","year":"2025","journal-title":"Transl. Res."},{"key":"10.1016\/j.addr.2025.115720_bb1075","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1021\/acsmacrolett.2c00699","article-title":"Design of Quorum Sensing Inhibitor-Polymer Conjugates to penetrate Pseudomonas aeruginosa biofilms","volume":"12","author":"Soukarieh","year":"2023","journal-title":"ACS Macro Lett."},{"key":"10.1016\/j.addr.2025.115720_bb1080","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127173","article-title":"Quorum quenching: a drug discovery approach against Pseudomonas aeruginosa","volume":"264","author":"Rather","year":"2022","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb1085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12964-023-01154-9","article-title":"It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy","volume":"21","author":"Naga","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.addr.2025.115720_bb1090","first-page":"100","article-title":"Molecular communication for quorum sensing inspired cooperative drug delivery, Ieee transactions on molecular biological and multi-scale","volume":"9","author":"Fang","year":"2023","journal-title":"Communications"},{"key":"10.1016\/j.addr.2025.115720_bb1095","series-title":"Inflammatory Microenvironment-Responsive Hydrogels Enclosed with Quorum Sensing Inhibitor for Treating Post-Traumatic Osteomyelitis - PubMed, Advanced Science (Weinheim, Baden-Wurttemberg, Germany)","volume":"vol. 11","author":"Z. W, L. H, Z. W, H. J, Z. Y, H. H, S. L, X. J, X. F","year":"2024"},{"key":"10.1016\/j.addr.2025.115720_bb1100","article-title":"A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms - PubMed","volume":"578","author":"Hmhn","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb1105","article-title":"Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1110","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.969326","article-title":"Biofilm aggregates and the host airway-microbial interface","volume":"12","author":"Hall-Stoodley","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.addr.2021.04.005","article-title":"Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms","volume":"174","author":"Birk","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb1120","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.2147\/IJN.S146195","article-title":"Nanotechnology-based drug delivery systems for control of microbial biofilms: a review","volume":"13","author":"Dos Santos Ramos","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115720_bb1125","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1021\/acs.biomac.1c00082","article-title":"Antibody-conjugated Nanocarriers for targeted antibiotic delivery: application in the treatment of bacterial biofilms","volume":"22","author":"Le","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.addr.2025.115720_bb1130","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acsmacrolett.9b00142","article-title":"Phosphorylcholine-based polymer encapsulated chitosan nanoparticles enhance the penetration of antimicrobials in a staphylococcal biofilm","volume":"8","author":"Cao","year":"2019","journal-title":"ACS Macro Lett."},{"key":"10.1016\/j.addr.2025.115720_bb1135","doi-asserted-by":"crossref","first-page":"10019","DOI":"10.1021\/acsnano.2c12151","article-title":"Inhibiting quorum sensing by active targeted pH-sensitive nanoparticles for enhanced antibiotic therapy of biofilm-associated bacterial infections","volume":"17","author":"Chen","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115720_bb1140","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/mi.2008.5","article-title":"Mucins in the mucosal barrier to infection","volume":"1","author":"Linden","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.addr.2025.115720_bb1145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2022.12.012","article-title":"Thiolated pectin-chitosan composites: potential mucoadhesive drug delivery system with selective cytotoxicity towards colorectal cancer","volume":"225","author":"Leonard","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115720_bb1150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejps.2017.01.008","article-title":"Thiolated polymers as mucoadhesive drug delivery systems","volume":"100","author":"Duggan","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1155","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.progpolymsci.2014.07.010","article-title":"Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review","volume":"39","author":"Sosnik","year":"2014","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1160","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/17425247.2023.2181331","article-title":"Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations","volume":"20","author":"Kulkarni","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2025.115720_bb1165","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1039\/D4TB00134F","article-title":"Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces","volume":"12","author":"Oh","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.addr.2025.115720_bb1170","doi-asserted-by":"crossref","first-page":"1137947","DOI":"10.3389\/fcimb.2023.1137947","article-title":"Understanding bacterial biofilms: from definition to treatment strategies","volume":"13","author":"Zhao","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1175","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jconrel.2023.01.003","article-title":"Smart delivery systems for microbial biofilm therapy: dissecting design, drug release and toxicological features","volume":"354","author":"Sousa","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb1180","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3934\/microbiol.2022019","article-title":"Biofilms: formation, drug resistance and alternatives to conventional approaches","volume":"8","author":"Mirghani","year":"2022","journal-title":"AIMS Microbiol"},{"key":"10.1016\/j.addr.2025.115720_bb1185","doi-asserted-by":"crossref","DOI":"10.1016\/j.tim.2020.03.016","article-title":"Biofilm Matrixome: extracellular components in structured microbial communities","volume":"28","author":"Karygianni","year":"2020","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1190","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15112582","article-title":"Nanotechnology-based drug delivery systems to control bacterial-biofilm-associated lung infections","volume":"15","author":"Guo","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115720_bb1195","article-title":"Advanced Nanotechnological approaches for biofilm prevention and control","volume":"14","author":"Ferraz","year":"2024","journal-title":"Appl. Sci. Basel"},{"key":"10.1016\/j.addr.2025.115720_bb1200","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41522-023-00427-y","article-title":"Strategy to combat biofilms: a focus on biofilm dispersal enzymes","volume":"9","author":"Wang","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb1205","article-title":"Designer Liposomic Nanocarriers are effective biofilm eradicators - PubMed","volume":"16","author":"K. M, O.-S. Y, D. T, M. MI, A. O, R. C, G. M, G. R, K. J","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115720_bb1210","first-page":"2831","article-title":"Bacteria-responsive biopolymer-coated nanoparticles for biofilm penetration and eradication, biomaterials","volume":"10","author":"Wang","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115720_bb1215","doi-asserted-by":"crossref","DOI":"10.3390\/ph16121671","article-title":"Bioactive-loaded hydrogels based on bacterial Nanocellulose, chitosan, and Poloxamer for rebalancing vaginal microbiota","volume":"16","author":"Moraru","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.addr.2025.115720_bb1220","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jconrel.2019.02.039","article-title":"Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of helicobacter pylori biofilm","volume":"300","author":"Li","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb1225","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","volume":"17","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2025.115720_bb1230","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.690600","article-title":"Hypoxia: the \"invisible pusher\" of gut microbiota","volume":"12","author":"Han","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115720_bb1235","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2025.115720_bb1240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/nu7010045","article-title":"Understanding how commensal obligate anaerobic bacteria regulate immune functions in the large intestine","volume":"7","author":"Maier","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2025.115720_bb1245","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1074\/jbc.REV120.011188","article-title":"Oxygen battle in the gut: hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine","volume":"295","author":"Singhal","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2025.115720_bb1250","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.biomaterials.2013.11.022","article-title":"Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery","volume":"35","author":"Thambi","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115720_bb1255","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1039\/C8CS00304A","article-title":"Hypoxia-targeted drug delivery","volume":"48","author":"Sharma","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb1260","first-page":"925","article-title":"Hypoxia-responsive host-guest drug delivery system, accounts of","volume":"4","author":"Hu","year":"2023","journal-title":"Mater. Res."},{"key":"10.1016\/j.addr.2025.115720_bb1265","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jconrel.2021.11.034","article-title":"Hypoxia-sensitive drug delivery to tumors","volume":"341","author":"Filipczak","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb1270","doi-asserted-by":"crossref","first-page":"12452","DOI":"10.1021\/acsanm.4c00826","article-title":"Hypoxia-responsive Nanomicelle based on 2-Nitroimidazole for tumor treatment through chemotherapy and modulation of the tumor redox microenvironment","volume":"7","author":"Zhu","year":"2024","journal-title":"Acs Appl. Nano Mater."},{"key":"10.1016\/j.addr.2025.115720_bb1275","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jconrel.2022.03.041","article-title":"Triggered azobenzene-based prodrugs and drug delivery systems","volume":"345","author":"Zhu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115720_bb1280","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202400635","article-title":"Recent advances of light\/hypoxia-responsive Azobenzene in nanomedicine design","volume":"25","author":"Zhao","year":"2024","journal-title":"Chembiochem"},{"key":"10.1016\/j.addr.2025.115720_bb1285","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.actbio.2018.10.029","article-title":"Nitroimidazole derivative incorporated liposomes for hypoxia-triggered drug delivery and enhanced therapeutic efficacy in patient-derived tumor xenografts","volume":"83","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2025.115720_bb1290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2023.129484","article-title":"Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole","volume":"95","author":"Tsuji","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.addr.2025.115720_bb1295","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1021\/acs.langmuir.1c03334","article-title":"Naphthalimide-based azo-functionalized supramolecular vesicle in hypoxia-responsive drug delivery","volume":"38","author":"Sarkar","year":"2022","journal-title":"Langmuir"},{"key":"10.1016\/j.addr.2025.115720_bb1300","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1021\/acs.molpharmaceut.0c00754","article-title":"Hypoxia-responsive, polymeric Nanocarriers for targeted drug delivery to estrogen receptor-positive breast Cancer cell spheroids","volume":"17","author":"Mamnoon","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2025.115720_bb1305","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.actbio.2020.07.061","article-title":"Azo-inserted responsive hybrid liposomes for hypoxia-specific drug delivery","volume":"115","author":"Long","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2025.115720_bb1310","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/10717544.2021.2021324","article-title":"Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy","volume":"29","author":"Liu","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.addr.2025.115720_bb1315","article-title":"Tailoring polymeric nanocarriers for hypoxia-specific drug release: insights into design and applications in clinics","volume":"496","author":"Joy","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.addr.2025.115720_bb1320","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1038\/s41467-022-33920-7","article-title":"Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb1325","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104854","article-title":"Biofilm-state probiotics: advanced alternatives to traditional probiotics","volume":"156","author":"Yao","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.addr.2025.115720_bb1330","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms4030035","article-title":"Biofilm forming Lactobacillus: new challenges for the development of probiotics","volume":"4","author":"Salas-Jara","year":"2016","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb1335","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/microbiolres12040068","article-title":"Probiotics as therapeutic tools against pathogenic biofilms: have we found the perfect weapon?","volume":"12","author":"Meroni","year":"2021","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb1340","doi-asserted-by":"crossref","first-page":"2126274","DOI":"10.1080\/19490976.2022.2126274","article-title":"Biofilm-based delivery approaches and specific enrichment strategies of probiotics in the human gut","volume":"14","author":"Gao","year":"2022","journal-title":"Gut Microbes"},{"key":"10.1016\/j.addr.2025.115720_bb1345","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9010027","article-title":"The use of probiotics to fight biofilms in medical devices: a systematic review and Meta-analysis","volume":"9","author":"Carvalho","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb1350","doi-asserted-by":"crossref","first-page":"eabb1952","DOI":"10.1126\/sciadv.abb1952","article-title":"Bioinspired oral delivery of gut microbiota by self-coating with biofilms","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115720_bb1355","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/nu13030918","article-title":"Lactobacillus reuteri in its biofilm state improves protection from experimental necrotizing enterocolitis","volume":"13","author":"Al-Hadidi","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2025.115720_bb1360","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41522-020-00159-3","article-title":"Intestinal release of biofilm-like microcolonies encased in calcium-pectinate beads increases probiotic properties of Lacticaseibacillus paracasei","volume":"6","author":"Heumann","year":"2020","journal-title":"npj Biofilms and Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb1365","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1007\/s11661-008-9603-5","article-title":"Clays, nanoclays, and montmorillonite minerals","volume":"39","author":"Uddin","year":"2008","journal-title":"Metall. Mater. Trans. A"},{"key":"10.1016\/j.addr.2025.115720_bb1370","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/S1479050507002128","article-title":"Effects of smectite clay on biofilm formation by microorganisms","volume":"3","author":"Alimova","year":"2006","journal-title":"Biofilms"},{"key":"10.1016\/j.addr.2025.115720_bb1375","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108706","article-title":"Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy","volume":"34","author":"Han","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.addr.2025.115720_bb1380","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jcis.2007.03.062","article-title":"Modeling the acid\u2013base surface chemistry of montmorillonite","volume":"312","author":"Bourg","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1385","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clay.2004.01.001","article-title":"Colloidal behavior of aqueous montmorillonite suspensions: the specific role of pH in the presence of indifferent electrolytes","volume":"27","author":"Tombacz","year":"2004","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1390","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118462","article-title":"Exfoliated bentonite\/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration","volume":"272","author":"Kim","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115720_bb1395","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41467-025-56498-2","article-title":"Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites","volume":"16","author":"Teng","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb1400","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2025.01.017","article-title":"Engineered commensals for targeted nose-to-brain drug delivery","volume":"vol. 188","author":"Shen","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115720_bb1405","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40168-021-01026-9","article-title":"Assessment of the microbiome during bacteriophage therapy in combination with systemic antibiotics to treat a case of staphylococcal device infection","volume":"9","author":"Mu","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.addr.2025.115720_bb1410","article-title":"Phage therapy with a focus on the human microbiota","volume":"8","author":"Divya Ganeshan","year":"2019","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.addr.2025.115720_bb1415","article-title":"Phage therapy: targeting intestinal bacterial microbiota for the treatment of liver diseases","volume":"5","author":"Fujiki","year":"2023","journal-title":"JHEP Rep"},{"key":"10.1016\/j.addr.2025.115720_bb1420","doi-asserted-by":"crossref","DOI":"10.1016\/j.amolm.2023.100029","article-title":"Gut microbiome associated dysbiosis: limited regimens and expanding horizons of phage therapy","volume":"2","author":"Singha","year":"2023","journal-title":"Aspects of Molecular Medicine"},{"key":"10.1016\/j.addr.2025.115720_bb1425","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cmi.2022.08.027","article-title":"Microbiome-phage interactions in inflammatory bowel disease","volume":"29","author":"Federici","year":"2023","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.addr.2025.115720_bb1430","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119622","article-title":"Restoration of dysbiotic human gut microbiome for homeostasis","volume":"278","author":"Dixit","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1435","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1016\/j.cell.2022.07.003","article-title":"Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation","volume":"185","author":"Federici","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115720_bb1440","first-page":"986","article-title":"Bacteriophages as nanocarriers for targeted drug delivery and enhanced therapeutic effects, materials","volume":"5","author":"Emencheta","year":"2024","journal-title":"Advances"},{"key":"10.1016\/j.addr.2025.115720_bb1445","series-title":"Progress in Molecular Biology and Translational Science, Academic Press","first-page":"191","article-title":"Chapter nine - phage for drug delivery vehicles","author":"Kumar","year":"2023"},{"issue":"5","key":"10.1016\/j.addr.2025.115720_bb1450","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3390\/bioengineering12050469","article-title":"Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities","volume":"12","author":"Venkataraman","year":"2025","journal-title":"Bioengineering"},{"key":"10.1016\/j.addr.2025.115720_bb1455","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12951-024-02576-4","article-title":"Phage-based delivery systems: engineering, applications, and challenges in nanomedicines","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.addr.2025.115720_bb1460","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.addr.2016.03.003","article-title":"Bacteriophages and phage-inspired nanocarriers for targeted delivery of therapeutic cargos","volume":"106","author":"Karimi","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb1465","first-page":"404","article-title":"Help, hope and hype: ethical considerations of human microbiome research and applications, protein","volume":"9","author":"Ma","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115720_bb1470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/6657515","article-title":"Current regulation and initial considerations for successful development and commercialization of microbiome therapies","volume":"2023","author":"Thanush","year":"2023","journal-title":"Advanced Gut & Microbiome Research"},{"key":"10.1016\/j.addr.2025.115720_bb1475","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41522-025-00683-0","article-title":"The regulatory framework for microbiome-based therapies: insights into European regulatory developments","volume":"11","author":"Rodriguez","year":"2025","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb1480","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114400","article-title":"Microbiome as an immune regulator in health, disease, and therapeutics","volume":"188","author":"Juarez","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115720_bb1485","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/apt.17049","article-title":"Review article: the future of microbiome-based therapeutics","volume":"56","author":"Gulliver","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"Suppl. 1","key":"10.1016\/j.addr.2025.115720_bb1490","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2010.05441.x","article-title":"Probiotics: from bench to market","volume":"1212","author":"Klein","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.addr.2025.115720_bb1495","first-page":"519","article-title":"Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment","volume":"40","author":"Turner","year":"2023","journal-title":"ALTEX"},{"key":"10.1016\/j.addr.2025.115720_bb1500","article-title":"Regulation, risk and safety of Faecal microbiota transplant, infection prevention","volume":"2","author":"Merrick","year":"2020","journal-title":"Practice"},{"key":"10.1016\/j.addr.2025.115720_bb1505","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s40168-024-01991-x","article-title":"Microbiome testing in Europe: navigating analytical, ethical and regulatory challenges","volume":"12","author":"Rodriguez","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.addr.2025.115720_bb1510","first-page":"583","article-title":"The lancet gastroenterology, direct-to-consumer microbiome testing needs regulation, lancet","volume":"9","author":"H.","year":"2024","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115720_bb1515","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2023.127336","article-title":"In vitro models to study human gut-microbiota interactions: applications, advances, and limitations","volume":"270","author":"Qi","year":"2023","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.addr.2025.115720_bb1520","doi-asserted-by":"crossref","DOI":"10.1093\/femsle\/fnaa097","article-title":"Intestinal fermentation in vitro models to study food-induced gut microbiota shift: an updated review","volume":"367","author":"Nissen","year":"2020","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.addr.2025.115720_bb1525","article-title":"In vitro models for investigating intestinal host-pathogen interactions","volume":"11","author":"McCoy","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.addr.2025.115720_bb1530","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1038\/s41467-019-12087-8","article-title":"An in vitro model maintaining taxon-specific functional activities of the gut microbiome","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115720_bb1535","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2021.05.028","article-title":"In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: a systematic review","volume":"335","author":"Fedi","year":"2021","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.addr.2025.115720_bb1540","doi-asserted-by":"crossref","DOI":"10.1007\/s42242-022-00210-6","article-title":"Designs and methodologies to recreate in vitro human gut microbiota models","volume":"6","author":"Biagini","year":"2022","journal-title":"Bio-Des. Manuf."},{"key":"10.1016\/j.addr.2025.115720_bb1545","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.actbio.2025.04.025","article-title":"A smart capsule with a bacteria- and pH-triggered enteric polymer coating for targeted colonic microbiome sampling","volume":"199","author":"Sarnaik","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2025.115720_bb1550","doi-asserted-by":"crossref","DOI":"10.1016\/j.afres.2022.100248","article-title":"A comprehensive review on microencapsulation of probiotics: technology, carriers and current trends","volume":"3","author":"Vivek","year":"2023","journal-title":"Appl. Food Res."},{"key":"10.1016\/j.addr.2025.115720_bb1555","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2021.108199","article-title":"Methodological advances and challenges in probiotic bacteria production: ongoing strategies and future perspectives","volume":"176","author":"Hathi","year":"2021","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.addr.2025.115720_bb1560","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7030083","article-title":"The production and delivery of probiotics: A Review of a Practical Approach","volume":"7","author":"Fenster","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115720_bb1565","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1038\/s41598-023-29637-2","article-title":"Effect of in vitro cultivation on human gut microbiota composition using 16S rDNA amplicon sequencing and metabolomics approach","volume":"13","author":"Srednicka","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115720_bb1570","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41522-022-00275-2","article-title":"Inter-species metabolic interactions in an in-vitro minimal human gut microbiome of Core Bacteria","volume":"8","author":"Shetty","year":"2022","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.addr.2025.115720_bb1575","article-title":"In vitro human gut microbiota fermentation models: opportunities, challenges, and pitfalls, microbiome","volume":"2","author":"Isenring","year":"2023","journal-title":"Research Reports"},{"key":"10.1016\/j.addr.2025.115720_bb1580","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.828359","article-title":"Frontiers | development of an in vitro model of human gut microbiota for screening the reciprocal interactions with antibiotics, drugs, and xenobiotics","volume":"13","author":"El Houari","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:59:00Z","timestamp":1780549140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X25002054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":316,"alternative-id":["S0169409X25002054"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2025.115720","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiome-active drug delivery systems (MADDS): Leveraging microbial stimuli for controlled drug release","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2025.115720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115720"}}