{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:39:49Z","timestamp":1791686389363,"version":"4.3.4"},"reference-count":277,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370860"],"award-info":[{"award-number":["82370860"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YJ202412"],"award-info":[{"award-number":["YJ202412"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["WELBIO-CR-2022 S\\u201301"],"award-info":[{"award-number":["WELBIO-CR-2022 S\\u201301"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["24YFHZ0326"],"award-info":[{"award-number":["24YFHZ0326"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.addr.2025.115741","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:02:48Z","timestamp":1763827368000},"page":"115741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation"],"prefix":"10.1016","volume":"228","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Beloqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2025.115741_bb0005","doi-asserted-by":"crossref","unstructured":"F. Bray, M. Laversanne, H. Sung, J. Ferlay, R.L. Siegel, I. Soerjomataram, A. Jemal, Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J. Clin., 74 (2024) 229\u2013263.","DOI":"10.3322\/caac.21834"},{"key":"10.1016\/j.addr.2025.115741_bb0010","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/cas.16063","article-title":"Anti-angiogenesis in colorectal cancer therapy","volume":"115","author":"Yang","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.addr.2025.115741_bb0015","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/jama.2021.0106","article-title":"Diagnosis and treatment of metastatic colorectal Cancer: A review","volume":"325","author":"Biller","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.addr.2025.115741_bb0020","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.addr.2025.115741_bb0025","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.3389\/fimmu.2020.01624","article-title":"Colorectal Cancer immunotherapy: options and strategies","volume":"11","author":"Johdi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb0030","doi-asserted-by":"crossref","first-page":"15065","DOI":"10.1038\/nrdp.2015.65","article-title":"Colorectal cancer","volume":"1","author":"Kuipers","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.addr.2025.115741_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512204","article-title":"Photodynamic therapy for colorectal Cancer: An update and a look to the future","volume":"24","author":"Rodrigues","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb0040","doi-asserted-by":"crossref","first-page":"1050421","DOI":"10.3389\/fimmu.2022.1050421","article-title":"Photodynamic therapy improves the clinical efficacy of advanced colorectal cancer and recruits immune cells into the tumor immune microenvironment","volume":"13","author":"Gu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb0045","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1021\/acs.molpharmaceut.0c00451","article-title":"Efficient colorectal Cancer gene therapy with IL-15 mRNA Nanoformulation","volume":"17","author":"Lei","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2025.115741_bb0050","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1470-2045(25)00083-X","article-title":"Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-Centre, phase 1 trial","volume":"26","author":"Lou","year":"2025","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0055","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/NAN.0b013e31824237ce","article-title":"Intravenous therapy: a review of complications and economic considerations of peripheral access","volume":"35","author":"Dychter","year":"2012","journal-title":"J. Infus. Nurs."},{"key":"10.1016\/j.addr.2025.115741_bb0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s44222-022-00006-4","article-title":"Bioinspired oral delivery devices","volume":"1","author":"Zhang","year":"2023","journal-title":"Nat Rev Bioeng"},{"key":"10.1016\/j.addr.2025.115741_bb0065","article-title":"Current advances of nanomaterial-based Oral drug delivery for colorectal Cancer treatment","volume":"14","author":"Wang","year":"2024","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114076","article-title":"Clinical translation of advanced colonic drug delivery technologies","volume":"181","author":"Awad","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0075","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41577-021-00534-x","article-title":"The inflammatory pathogenesis of colorectal cancer","volume":"21","author":"Schmitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-024-07747-9","article-title":"The genomic landscape of 2,023 colorectal cancers","volume":"633","author":"Cornish","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115741_bb0085","first-page":"3089","article-title":"Photothermal therapy technology of metastatic colorectal cancer","volume":"12","author":"Chen","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.addr.2025.115741_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115117","article-title":"Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease","volume":"203","author":"Chen","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115130","article-title":"Nanocarriers transport across the gastrointestinal barriers: the contribution to oral bioavailability via blood circulation and lymphatic pathway","volume":"203","author":"Wang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0100","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jconrel.2020.04.006","article-title":"Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems","volume":"322","author":"Xu","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.670124","article-title":"Orally administrable therapeutic nanoparticles for the treatment of colorectal Cancer","volume":"9","author":"Ying","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb0110","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0115","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0120","first-page":"19","article-title":"Genetic alterations in colorectal cancer, Gastrointest","volume":"5","author":"Armaghany","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.addr.2025.115741_bb0125","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5217\/ir.2018.16.3.327","article-title":"Genetic and epigenetic alterations of colorectal cancer","volume":"16","author":"Hong","year":"2018","journal-title":"Intest Res"},{"key":"10.1016\/j.addr.2025.115741_bb0135","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1186\/s12967-025-06640-x","article-title":"The interplay between driver mutation and oxidative stress in colorectal cancer: from pathogenesis to therapeutics","volume":"23","author":"Huang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.critrevonc.2019.02.010","article-title":"Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer","volume":"137","author":"Gonzalez-Avila","year":"2019","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.addr.2025.115741_bb0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-024-01899-w","article-title":"Therapeutic advances of targeting receptor tyrosine kinases in cancer","volume":"9","author":"Tomuleasa","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0150","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic signaling pathways and anti-angiogenic therapy for cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0155","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: the expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.addr.2025.115741_bb0160","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb0165","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.3748\/wjg.v28.i32.4475","article-title":"Colon mucus in colorectal neoplasia and beyond","volume":"28","author":"Loktionov","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0170","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/s41588-022-01088-x","article-title":"Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer","volume":"54","author":"Becker","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.addr.2025.115741_bb0175","doi-asserted-by":"crossref","first-page":"1974795","DOI":"10.1080\/19490976.2021.1974795","article-title":"Mucins, gut microbiota, and postbiotics role in colorectal cancer","volume":"13","author":"Pothuraju","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.addr.2025.115741_bb0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40168-018-0451-2","article-title":"Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers","volume":"6","author":"Dai","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.addr.2025.115741_bb0185","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0190","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","article-title":"Intestinal short chain fatty acids and their link with diet and human health","volume":"7","author":"Rios-Covian","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115741_bb0195","first-page":"2617","article-title":"An insight into the intestinal web of mucosal immunity","volume":"9","author":"Yap","year":"2018","journal-title":"Microbiota, and Diet in Inflammation, Front Immunol"},{"key":"10.1016\/j.addr.2025.115741_bb0200","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/1146\/1\/012037","article-title":"Altered profile of gut microbiota and the level short chain fatty acids in colorectal cancer patients","volume":"1146","author":"Yusuf","year":"2019","journal-title":"J. Phys. Conf. Ser."},{"key":"10.1016\/j.addr.2025.115741_bb0205","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1136\/gutjnl-2019-318593","article-title":"Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: a matched case-control study","volume":"68","author":"Zhang","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.addr.2025.115741_bb0210","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0220","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-024-01953-7","article-title":"Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0225","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1200\/JCO.22.01690","article-title":"Treatment of metastatic colorectal Cancer: ASCO guideline","volume":"41","author":"Morris","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0230","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"E.G.C.E.a. clinicalguidelines@esmo.org, Metastatic colorectal cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2023","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0235","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41575-024-01025-9","article-title":"Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer","volume":"22","author":"Sievers","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166880","article-title":"Small-molecule drugs of colorectal cancer: current status and future directions","volume":"1870","author":"Yang","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.addr.2025.115741_bb0245","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.addr.2025.115741_bb0250","article-title":"The incidence and severity of patient-reported side effects of chemotherapy in routine clinical care: A prospective observational study","volume":"15","author":"Katta","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.addr.2025.115741_bb0255","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41416-020-0926-3","article-title":"How promising is phototherapy for cancer?","volume":"123","author":"Shi","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb0260","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0265","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1177\/15533506221083545","article-title":"Photodynamic therapy for colorectal Cancer: A systematic review of clinical research","volume":"29","author":"Guidolin","year":"2022","journal-title":"Surg. Innov."},{"key":"10.1016\/j.addr.2025.115741_bb0270","doi-asserted-by":"crossref","first-page":"2200342","DOI":"10.1002\/adtp.202200342","article-title":"Development of a clinically viable strategy for nanoparticle-based photodynamic therapy of colorectal Cancer","volume":"6","author":"Guidolin","year":"2023","journal-title":"Adv Ther-Germany"},{"key":"10.1016\/j.addr.2025.115741_bb0275","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-025-02140-y","article-title":"Phototherapy in cancer treatment: strategies and challenges","volume":"10","author":"Cai","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0280","doi-asserted-by":"crossref","first-page":"11353","DOI":"10.1021\/acsanm.1c01903","article-title":"Review of functionalized nanomaterials for Photothermal therapy of cancers","volume":"4","author":"Bian","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.addr.2025.115741_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21334","article-title":"Nanoparticles for imaging-guided photothermal therapy of colorectal cancer","volume":"9","author":"Farzam","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.addr.2025.115741_bb0290","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan4672","article-title":"Gene therapy comes of age","volume":"359","author":"Dunbar","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115741_bb0295","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303261","article-title":"Lipid nanoparticle (LNP) enables mRNA delivery for Cancer therapy","volume":"35","author":"Zong","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.addr.2025.115741_bb0300","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41565-024-01769-0","article-title":"Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR-Cas gene editing","volume":"19","author":"Zhao","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb0305","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrc1147","article-title":"Clinical development of gene therapy for colorectal cancer","volume":"3","author":"Kerr","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb0310","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1517\/14712598.3.5.779","article-title":"Gene therapy for colorectal cancer","volume":"3","author":"Kerr","year":"2003","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120375","article-title":"Gene therapy: comprehensive overview and therapeutic applications","volume":"294","author":"Sayed","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2025.115741_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111941","article-title":"Gene therapy targeting p53 and KRAS for colorectal Cancer treatment: A myth or the way forward?","volume":"22","author":"Hasbullah","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb0325","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jconrel.2009.10.027","article-title":"Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure","volume":"142","author":"Suzuki","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0330","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1001\/jamaoncol.2024.3891","article-title":"Chimeric antigen receptor T cells targeting CD19 and GCC in metastatic colorectal Cancer: A nonrandomized clinical trial","volume":"10","author":"Chen","year":"2024","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0335","doi-asserted-by":"crossref","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.addr.2025.115741_bb0340","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1200\/JCO-24-02081","article-title":"Chimeric antigen receptor-T cells in colorectal Cancer: pioneering new avenues in solid tumor immunotherapy","volume":"43","author":"Ouladan","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0345","doi-asserted-by":"crossref","first-page":"9761","DOI":"10.1021\/acs.nanolett.1c03708","article-title":"A duplex CRISPR-Cas9 ribonucleoprotein nanomedicine for colorectal Cancer gene therapy","volume":"21","author":"Wan","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2025.115741_bb0350","doi-asserted-by":"crossref","first-page":"10541","DOI":"10.1038\/s41598-017-10940-8","article-title":"Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment","volume":"7","author":"Yeku","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115741_bb0355","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3343\/alm.2023.0382","article-title":"Manufacturing cell and gene therapies: challenges in clinical translation","volume":"44","author":"Lee","year":"2024","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0360","first-page":"129","article-title":"Understanding compliance issues for daily self-injectable treatment in ambulatory care settings","volume":"2","author":"Brod","year":"2008","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.addr.2025.115741_bb0365","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11030129","article-title":"Challenges and recent Progress in Oral drug delivery Systems for Biopharmaceuticals","volume":"11","author":"Homayun","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107447","article-title":"5-fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future","volume":"206","author":"Vodenkova","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0375","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/sonc.2002.35524","article-title":"Oxaliplatin-related side effects: characteristics and management","volume":"29","author":"Cassidy","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0380","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2165\/00002018-200528050-00005","article-title":"Benefit-risk assessment of irinotecan in advanced colorectal cancer","volume":"28","author":"Glimelius","year":"2005","journal-title":"Drug Saf."},{"key":"10.1016\/j.addr.2025.115741_bb0385","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/annonc\/mdg100","article-title":"O. Arbeitsgemeinschaft Gastrointestinale, 5-fluorouracil plus leucovorin is an effective adjuvant chemotherapy in curatively resected stage III colon cancer: long-term follow-up results of the adjCCA-01 trial","volume":"14","author":"Arkenau","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0390","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/CAD.0b013e3282f945aa","article-title":"Capecitabine: an overview of the side effects and their management","volume":"19","author":"Saif","year":"2008","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.addr.2025.115741_bb0395","first-page":"837","article-title":"Prevention and management of adverse events related to regorafenib","volume":"22","author":"De Wit","year":"2014","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb0400","first-page":"85","article-title":"Adherence, dosing, and managing toxicities with Trifluridine\/Tipiracil (TAS-102)","volume":"16","author":"Lee","year":"2017","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb0405","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.3748\/wjg.v19.i31.5051","article-title":"Role of bevacizumab in colorectal cancer growth and its adverse effects: a review","volume":"19","author":"Pavlidis","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0410","first-page":"77","article-title":"Cetuximab in the management of colorectal cancer","volume":"1","author":"Lenz","year":"2007","journal-title":"Biologics"},{"key":"10.1016\/j.addr.2025.115741_bb0415","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1756283X13498660","article-title":"Panitumumab in the management of patients with KRAS wild-type metastatic colorectal cancer","volume":"7","author":"Hocking","year":"2014","journal-title":"Therap. Adv. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0420","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1470-2045(22)00197-8","article-title":"Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-label, phase 3 study","volume":"23","author":"Diaz","year":"2022","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0425","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008689","article-title":"Nivolumab plus Relatlimab in Patients with Previously Treated Microsatellite Instability-High\/Mismatch Repair-Deficient Metastatic Colorectal cancer: The Phase II CheckMate 142 Study","volume":"12","author":"Overman","year":"2024","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb0430","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.annonc.2022.06.008","article-title":"Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high\/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142","volume":"33","author":"Andre","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.addr.2025.115741_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020484","article-title":"Advances in Oral drug delivery systems: challenges and opportunities","volume":"15","author":"Lou","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb0440","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.maturitas.2014.12.017","article-title":"Diet and colorectal cancer","volume":"80","author":"Baena","year":"2015","journal-title":"Maturitas"},{"key":"10.1016\/j.addr.2025.115741_bb0445","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/j.gastro.2014.12.035","article-title":"Nutrients, foods, and colorectal cancer prevention","volume":"148","author":"Song","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2025.115741_bb0450","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.chom.2018.05.012","article-title":"The impact of dietary Fiber on gut microbiota in host health and disease","volume":"23","author":"Makki","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2025.115741_bb0455","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d6617","article-title":"Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies","volume":"343","author":"Aune","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.addr.2025.115741_bb0460","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/s41591-022-01965-2","article-title":"Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome","volume":"28","author":"Simpson","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0465","first-page":"1","volume":"239","author":"Greenwood-Van Meerveld","year":"2017","journal-title":"Gastrointestinal Physiology and Function, Handb. Exp. Pharmacol."},{"key":"10.1016\/j.addr.2025.115741_bb0470","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.3748\/wjg.v20.i22.6774","article-title":"Inflammatory colonic carcinogenesis: a review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis","volume":"20","author":"Scarpa","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015366","article-title":"The inflammatory microenvironment in colorectal neoplasia","volume":"6","author":"McLean","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.addr.2025.115741_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/biom12060784","article-title":"Nano-based approved Pharmaceuticals for Cancer Treatment: present and future challenges","volume":"12","author":"Rodriguez","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.addr.2025.115741_bb0485","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.2147\/IJN.S466490","article-title":"Research advances of lipid nanoparticles in the treatment of colorectal Cancer","volume":"19","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115741_bb0490","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jare.2021.11.008","article-title":"Polymeric nanocarriers: A promising tool for early diagnosis and efficient treatment of colorectal cancer","volume":"39","author":"Haider","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.addr.2025.115741_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2023.111877","article-title":"Hybrid lipid-polymer nanoplatform: A systematic review for targeted colorectal cancer therapy","volume":"186","author":"Dave","year":"2023","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.addr.2025.115741_bb0500","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.3748\/wjg.v28.i46.6497","article-title":"Nanotechnology for colorectal cancer detection and treatment","volume":"28","author":"Gogoi","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb0505","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jconrel.2022.12.029","article-title":"Colonic drug delivery: formulating the next generation of colon-targeted therapeutics","volume":"353","author":"McCoubrey","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0510","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020587","article-title":"A systematic overview of Eudragit((R)) based copolymer for smart healthcare","volume":"15","author":"Nikam","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113849","article-title":"Eudragit S100 coated nanodiamond-based nanoparticles as an oral chemo-photothermal delivery system for local treatment of colon cancer","volume":"237","author":"Su","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2025.115741_bb0520","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1021\/acsnano.2c09266","article-title":"Oral delivery of therapeutic antibodies with a Transmucosal polymeric carrier","volume":"17","author":"Zhu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101834","article-title":"Oral delivery of anti-PD-L1 antibody for cancer immunotherapy against orthotopic colorectal tumors","volume":"50","author":"Chen","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.addr.2025.115741_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117893","article-title":"Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy","volume":"261","author":"Narayan","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115741_bb0535","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ijbiomac.2021.12.189","article-title":"Fabrication of cellulose nanocrystals as potential anticancer drug delivery systems for colorectal cancer treatment","volume":"199","author":"Yusefi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115741_bb0540","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jconrel.2021.04.026","article-title":"Oral delivery of micro\/nanoparticulate systems based on natural polysaccharides for intestinal diseases therapy: challenges, advances and future perspectives","volume":"334","author":"Dos Santos","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0545","doi-asserted-by":"crossref","DOI":"10.3390\/foods13020188","article-title":"Development of pectin particles as a Colon-targeted marjoram phenolic compound delivery system","volume":"13","author":"Siles-Sanchez","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.addr.2025.115741_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119413","article-title":"Starch hydrogels as targeted colonic drug delivery vehicles","volume":"289","author":"Koev","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115741_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125952","article-title":"Oral colon-targeted responsive alginate\/hyaluronic acid-based hydrogel propels the application of infliximab in colitis","volume":"249","author":"Huai","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115741_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119351","article-title":"Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease","volume":"288","author":"Kulkarni","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.addr.2025.115741_bb0565","first-page":"115","article-title":"Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat","volume":"1","author":"Varshosaz","year":"2010","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.addr.2025.115741_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127672","article-title":"Chondroitin Sulphate: An emerging therapeutic multidimensional proteoglycan in colon cancer","volume":"254","author":"Mneimneh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115741_bb0575","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2174\/1567201817666200527133719","article-title":"Inulin as a delivery vehicle for targeting Colon-specific Cancer","volume":"17","author":"Chadha","year":"2020","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.addr.2025.115741_bb0580","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3109\/1061186X.2015.1128941","article-title":"Polysaccharide-based micro\/nanocarriers for oral colon-targeted drug delivery","volume":"24","author":"Zhang","year":"2016","journal-title":"J. Drug Target."},{"key":"10.1016\/j.addr.2025.115741_bb0585","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1208\/s12249-019-1589-3","article-title":"Guar gum Micro-particles for targeted co-delivery of doxorubicin and metformin HCL for improved specificity and efficacy against Colon Cancer","volume":"21","author":"Kang","year":"2020","journal-title":"In Vitro and In Vivo Studies, AAPS PharmSciTech"},{"key":"10.1016\/j.addr.2025.115741_bb0590","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202004529","article-title":"Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress Colon Cancer","volume":"32","author":"Zheng","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.addr.2025.115741_bb0595","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jconrel.2022.09.024","article-title":"Mucoadhesive carriers for oral drug delivery","volume":"351","author":"Kumar","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0600","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1773-2247(12)50046-8","article-title":"The role of chitosan as a mucoadhesive agent in mucosal drug delivery","volume":"22","author":"Sandri","year":"2012","journal-title":"J Drug Deliv Sci Tec"},{"key":"10.1016\/j.addr.2025.115741_bb0605","article-title":"Alginate particles as platform for drug delivery by the Oral route: state-of-the-art","volume":"2014","author":"Sosnik","year":"2014","journal-title":"ISRN Pharm"},{"key":"10.1016\/j.addr.2025.115741_bb0610","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.2147\/IJN.S124318","article-title":"Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery","volume":"12","author":"Bhandari","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115741_bb0615","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.7150\/thno.38081","article-title":"Orally deliverable Nanotherapeutics for the synergistic treatment of colitis-associated colorectal Cancer","volume":"9","author":"Han","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2025.115741_bb0620","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.7150\/thno.40318","article-title":"Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and curcumin for targeted colorectal cancer therapy","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2025.115741_bb0625","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb0630","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s12951-022-01539-x","article-title":"Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems","volume":"20","author":"Subramanian","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.addr.2025.115741_bb0635","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.addr.2017.08.010","article-title":"PEGylation for enhancing nanoparticle diffusion in mucus","volume":"124","author":"Huckaby","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0640","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpb.2017.12.017","article-title":"Mucus-penetrating solid lipid nanoparticles for the treatment of cystic fibrosis: proof of concept, challenges and pitfalls","volume":"124","author":"Nafee","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2025.115741_bb0645","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.actbio.2021.12.015","article-title":"Impact of PEGylation on an antibody-loaded nanoparticle-based drug delivery system for the treatment of inflammatory bowel disease","volume":"140","author":"Shrestha","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.addr.2025.115741_bb0650","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41551-024-01224-4","article-title":"Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria","volume":"8","author":"Chen","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.addr.2025.115741_bb0655","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/s41467-025-57045-9","article-title":"Bioactive nanomotor enabling efficient intestinal barrier penetration for colorectal cancer therapy","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb0660","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203466","article-title":"Oral Nanomotor-enabled mucus traverse and tumor penetration for targeted chemo-Sono-immunotherapy against Colon Cancer","volume":"18","author":"Cao","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.addr.2025.115741_bb0665","doi-asserted-by":"crossref","first-page":"17228","DOI":"10.1021\/acsnano.4c07866","article-title":"Acoustic-magnetic responsive Nanomotor augments Oral drug delivery by gastrointestinal site navigation and mucus layer penetration","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0670","doi-asserted-by":"crossref","first-page":"16701","DOI":"10.1021\/acsnano.4c01760","article-title":"Catalase-powered Nanobots for overcoming the mucus barrier","volume":"18","author":"Serra-Casablancas","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0675","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1021\/acsnano.3c11436","article-title":"An Oral nanomedicine elicits in situ vaccination effect against colorectal Cancer","volume":"18","author":"Zu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122530","article-title":"Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation","volume":"307","author":"Li","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb0685","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13205037","article-title":"Microenvironmental reactive oxygen species in colorectal Cancer: involved processes and therapeutic opportunities","volume":"13","author":"Sorolla","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113675","article-title":"Enzymatic absorption promoters for non-invasive peptide delivery","volume":"382","author":"Steiger","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0695","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.addr.2017.12.006","article-title":"Efficacy and safety concerns over the use of mucus modulating agents for drug delivery using nanoscale systems","volume":"124","author":"Chater","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0700","first-page":"573","article-title":"The intestinal barrier: a pivotal role in health, inflammation, and cancer, lancet","volume":"10","author":"Neurath","year":"2025","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb0705","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17040397","article-title":"Barriers and strategies for Oral peptide and protein therapeutics delivery: update on clinical advances","volume":"17","author":"Baral","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.104967","article-title":"Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems","volume":"137","author":"Boyd","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb0715","article-title":"Gastrointestinal permeation enhancers beyond sodium Caprate and SNAC - what is coming next?","volume":"11","author":"Bohley","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.addr.2025.115741_bb0720","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nantod.2014.04.008","article-title":"Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects","volume":"9","author":"Barua","year":"2014","journal-title":"Nano Today"},{"key":"10.1016\/j.addr.2025.115741_bb0725","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.addr.2016.06.005","article-title":"Intestinal permeation enhancers for oral peptide delivery","volume":"106","author":"Maher","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0730","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1361900","article-title":"Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system","volume":"5","author":"Danielsen","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.addr.2025.115741_bb0735","doi-asserted-by":"crossref","first-page":"14451","DOI":"10.3390\/molecules200814451","article-title":"Absorption-enhancing effects of bile salts","volume":"20","author":"Moghimipour","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.addr.2025.115741_bb0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113925","article-title":"Formulation strategies to improve the efficacy of intestinal permeation enhancers","volume":"177","author":"Maher","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0745","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17020238","article-title":"Advances in Oral biomacromolecule therapies for metabolic diseases","volume":"17","author":"Jiao","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb0750","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1021\/mp400282r","article-title":"Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin E succinate nanomicelles based on a mucus bioadhesion and penetration mechanism","volume":"10","author":"Lian","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.addr.2025.115741_bb0755","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118840","article-title":"Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel","volume":"573","author":"Wang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115741_bb0760","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110554","article-title":"Oral delivery of paclitaxel by polymeric micelles: A comparison of different block length on uptake, permeability and oral bioavailability","volume":"184","author":"Sze","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.addr.2025.115741_bb0765","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jconrel.2022.07.029","article-title":"Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce colorectal cancer","volume":"349","author":"Almeida","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0770","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nantod.2012.01.002","article-title":"Polymeric micelle stability","volume":"7","author":"Owen","year":"2012","journal-title":"Nano Today"},{"key":"10.1016\/j.addr.2025.115741_bb0775","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1021\/acsnano.9b06689","article-title":"Fluorinated chitosan to enhance Transmucosal delivery of Sonosensitizer-conjugated catalase for Sonodynamic bladder Cancer treatment post-intravesical instillation","volume":"14","author":"Li","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0780","article-title":"The protein Corona paradox: challenges in achieving true biomimetics in nanomedicines","volume":"10","author":"Mayordomo","year":"2025","journal-title":"Biomimetics (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb0785","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jconrel.2023.09.049","article-title":"The biomolecular gastrointestinal corona in oral drug delivery","volume":"363","author":"Aljabbari","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0790","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/med.21767","article-title":"Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles","volume":"41","author":"Zhang","year":"2020","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0795","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1080\/17425247.2022.2093854","article-title":"Protein corona: challenges and opportunities for targeted delivery of nanomedicines","volume":"19","author":"Jiang","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.addr.2025.115741_bb0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114356","article-title":"The effects of protein corona on in vivo fate of nanocarriers","volume":"186","author":"Xiao","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0805","doi-asserted-by":"crossref","first-page":"35310","DOI":"10.1021\/acsnano.4c11453","article-title":"Enhanced gut-to-liver Oral drug delivery via ligand-modified nanoparticles by attenuating protein Corona adsorption","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0810","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.1021\/acsnano.3c11315","article-title":"Protein coronas derived from mucus act as both spear and shield to regulate transferrin functionalized nanoparticle transcellular transport in enterocytes","volume":"18","author":"Yang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0815","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.apsb.2023.02.012","article-title":"Disease-specific protein corona formed in pathological intestine enhances the oral absorption of nanoparticles","volume":"13","author":"Wu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.addr.2025.115741_bb0820","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fbioe.2020.00166","article-title":"Recent advances in understanding the protein Corona of nanoparticles and in the formulation of \"stealthy\" nanomaterials","volume":"8","author":"Rampado","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb0825","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-024-01889-y","article-title":"Current advance of nanotechnology in diagnosis and treatment for malignant tumors","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115741_bb0830","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jconrel.2023.09.014","article-title":"Nano-enabled colorectal cancer therapy","volume":"362","author":"Pan","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0835","article-title":"Oral delivery of multicompartment nanomedicines for colorectal Cancer therapeutics: combining loco-regional delivery with cell-target specificity","volume":"3","author":"Akhter","year":"2020","journal-title":"Adv Ther-Germany"},{"key":"10.1016\/j.addr.2025.115741_bb0840","doi-asserted-by":"crossref","first-page":"17745","DOI":"10.1039\/C5NR04831A","article-title":"Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy","volume":"7","author":"Xiao","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2025.115741_bb0845","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2217\/nnm-2023-0096","article-title":"Hyaluronic acid oligosaccharide-modified zeolitic imidazolate framework-8 nanoparticles loaded with oxaliplatin as a targeted drug-delivery system for colorectal cancer therapy","volume":"18","author":"Li","year":"2023","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.addr.2025.115741_bb0850","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121440","article-title":"Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer","volume":"283","author":"Hou","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb0855","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10555-020-09898-3","article-title":"Expression and function of epithelial cell adhesion molecule EpCAM: where are we after 40 years?","volume":"39","author":"Gires","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.addr.2025.115741_bb0860","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114443","article-title":"Targeted EpCAM-binding for the development of potent and effective anticancer proteins","volume":"161","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.addr.2025.115741_bb0865","doi-asserted-by":"crossref","DOI":"10.3390\/cells13030245","article-title":"Update on targeted therapy and immunotherapy for metastatic colorectal Cancer","volume":"13","author":"Underwood","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.addr.2025.115741_bb0870","doi-asserted-by":"crossref","first-page":"14818","DOI":"10.1002\/jcp.28281","article-title":"Targeting siRNA in colorectal cancer therapy: nanotechnology comes into view","volume":"234","author":"Aghamiri","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.addr.2025.115741_bb0875","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/s41467-023-37020-y","article-title":"Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer","volume":"14","author":"Hu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103507","article-title":"Oral delivery of nucleic acid therapeutics: challenges, strategies, and opportunities","volume":"28","author":"Jiang","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.addr.2025.115741_bb0885","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1021\/acsnano.7b08499","article-title":"Silencing of intestinal glycoprotein CD98 by orally targeted nanoparticles enhances Chemosensitization of Colon Cancer","volume":"12","author":"Xiao","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0890","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/s41598-018-20632-6","article-title":"Oral delivery of siRNA lipid nanoparticles: fate in the GI tract","volume":"8","author":"Ball","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115741_bb0895","doi-asserted-by":"crossref","first-page":"eabn3917","DOI":"10.1126\/sciadv.abn3917","article-title":"Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115741_bb0900","doi-asserted-by":"crossref","first-page":"28212","DOI":"10.1021\/acsnano.4c08044","article-title":"Innovative Oral Nano\/gene delivery system based on engineered modified Saccharomyces cerevisiae for colorectal Cancer therapy","volume":"18","author":"Shen","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0905","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.2217\/nnm-2016-0194","article-title":"Targeted nanoparticles for colorectal cancer","volume":"11","author":"Cisterna","year":"2016","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.addr.2025.115741_bb0910","doi-asserted-by":"crossref","first-page":"7915","DOI":"10.1038\/s41467-023-43746-6","article-title":"Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb0915","doi-asserted-by":"crossref","first-page":"23497","DOI":"10.1021\/acsnano.4c07115","article-title":"Oral Saccharomyces cerevisiae-guided enzyme prodrug therapy combined with immunotherapy for the treatment of Orthotopic colorectal Cancer","volume":"18","author":"Qin","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0920","doi-asserted-by":"crossref","first-page":"eadm9561","DOI":"10.1126\/sciadv.adm9561","article-title":"Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer","volume":"10","author":"Fan","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115741_bb0925","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201700141","article-title":"ROS-responsive Polyprodrug nanoparticles for triggered drug delivery and effective Cancer therapy","volume":"29","author":"Xu","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.addr.2025.115741_bb0930","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.biomaterials.2018.12.032","article-title":"Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release","volume":"195","author":"Yin","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb0935","doi-asserted-by":"crossref","first-page":"2001853","DOI":"10.1002\/advs.202001853","article-title":"Polymeric nanoparticles with ROS-responsive prodrug and platinum Nanozyme for enhanced Chemophotodynamic therapy of Colon Cancer","volume":"7","author":"Hao","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.addr.2025.115741_bb0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121856","article-title":"Activating cGAS-STING pathway with ROS-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy","volume":"290","author":"Cao","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb0945","article-title":"ROS-responsive nanoparticles for oral delivery of luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment","volume":"14","author":"Tan","year":"2022","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.addr.2025.115741_bb0950","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jconrel.2019.10.054","article-title":"A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease","volume":"316","author":"Li","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb0955","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122274","article-title":"Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota","volume":"301","author":"Huang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb0960","doi-asserted-by":"crossref","first-page":"17287","DOI":"10.1021\/acsnano.4c14373","article-title":"Reactive oxygen species-responsive polymer drug delivery system targeted oxidative stressed Colon cells to ameliorate colitis","volume":"19","author":"Cai","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2025.115741_bb0965","article-title":"Microfluidized dextran microgels loaded with cisplatin\/SPION lipid Nanotherapeutics for local Colon Cancer treatment via Oral administration","volume":"11","author":"Lu","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.addr.2025.115741_bb0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125262","article-title":"Folic acid-targeted beta-lactoglobulin nanocarriers for enhanced delivery of 5-fluorouracil and sodium butyrate in colorectal cancer treatment","volume":"671","author":"Heydarian","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.addr.2025.115741_bb0975","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/ma8030832","article-title":"Eudragit S100 coated Citrus pectin nanoparticles for Colon targeting of 5-fluorouracil","volume":"8","author":"Subudhi","year":"2015","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb0980","first-page":"299","article-title":"Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles","volume":"11","author":"Desai","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115741_bb0985","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12911-025-03134-0","article-title":"Exploring doctors' perspectives on precision medicine and AI in colorectal cancer: opportunities and challenges for the doctor-patient relationship","volume":"25","author":"Ancillotti","year":"2025","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"10.1016\/j.addr.2025.115741_bb0990","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.213","article-title":"The challenge and opportunity of gut microbiota-targeted nanomedicine for colorectal cancer therapy","volume":"3","author":"Wei","year":"2024","journal-title":"Imeta"},{"key":"10.1016\/j.addr.2025.115741_bb0995","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jcis.2024.07.010","article-title":"Sono-promoted piezocatalysis and low-dose drug penetration for personalized therapy via tumor organoids","volume":"675","author":"Gong","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1000","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.2147\/IJN.S375229","article-title":"Current advances in chitosan nanoparticles based Oral drug delivery for colorectal Cancer treatment","volume":"17","author":"Choukaife","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.addr.2025.115741_bb1005","doi-asserted-by":"crossref","DOI":"10.1504\/IJBNN.2013.054515","article-title":"Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps","volume":"3","author":"Bergin","year":"2013","journal-title":"Int. J. Biomed. Nanosci. Nanotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb1010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.etap.2010.05.004","article-title":"Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles","volume":"30","author":"Park","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.addr.2025.115741_bb1015","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101834","article-title":"Oral delivery of anti-PD-L1 antibody for cancer immunotherapy against orthotopic colorectal tumors","volume":"50","author":"Chen","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.addr.2025.115741_bb1020","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14225685","article-title":"The role of the microbiome on the pathogenesis and treatment of colorectal Cancer","volume":"14","author":"Yu","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb1030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gastro\/gox031","article-title":"Dysbiosis of gut microbiota in promoting the development of colorectal cancer","volume":"6","author":"Zou","year":"2018","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.addr.2025.115741_bb1035","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e29495","article-title":"Gut microbiota and their derivatives in the progression of colorectal cancer: mechanisms of action, genome and epigenome contributions","volume":"10","author":"Ahmad","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.addr.2025.115741_bb1040","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217459","article-title":"Modulating the gut microbiota: A novel perspective in colorectal cancer treatment","volume":"612","author":"Bai","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.addr.2025.115741_bb1045","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2011.244","article-title":"Fecal microbiota transplantation and emerging applications","volume":"9","author":"Borody","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb1050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ebiom.2019.10.015","article-title":"Faecal microbiota transplantation, a promising way to treat colorectal cancer","volume":"49","author":"Ma","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.addr.2025.115741_bb1055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.104967","article-title":"Fecal microbiota transplantation: no longer cinderella in tumour immunotherapy","volume":"100","author":"Yang","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.addr.2025.115741_bb1060","doi-asserted-by":"crossref","first-page":"1126808","DOI":"10.3389\/fmicb.2023.1126808","article-title":"Fecal microbiota transplantation inhibits colorectal cancer progression: reversing intestinal microbial dysbiosis to enhance anti-cancer immune responses","volume":"14","author":"Yu","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115741_bb1065","article-title":"Fecal microbiota transplantation prevents intestinal injury, upregulation of toll-like receptors, and 5-fluorouracil\/Oxaliplatin-induced toxicity in colorectal Cancer","volume":"21","author":"Chang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115741_bb1075","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00262-022-03169-6","article-title":"Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors","volume":"71","author":"Shaikh","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.addr.2025.115741_bb1080","article-title":"Metagenomic and metabolomic analyses reveal synergistic effects of fecal microbiota transplantation and anti-PD-1 therapy on treating colorectal cancer","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb1085","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12020234","article-title":"The potential impact of probiotics on human health: An update on their health-promoting properties","volume":"12","author":"Maftei","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.addr.2025.115741_bb1090","doi-asserted-by":"crossref","first-page":"1216674","DOI":"10.3389\/fmicb.2023.1216674","article-title":"Probiotics: mechanism of action, health benefits and their application in food industries","volume":"14","author":"Latif","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115741_bb1095","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.3748\/wjg.v28.i27.3370","article-title":"Probiotics and postbiotics in colorectal cancer: prevention and complementary therapy","volume":"28","author":"Kvakova","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.addr.2025.115741_bb1100","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.7314\/APJCP.2015.16.9.3621","article-title":"Associations of probiotics with vitamin D and leptin receptors and their effects on Colon Cancer","volume":"16","author":"Ranji","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.addr.2025.115741_bb1105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10620-008-0363-2","article-title":"Estimation of the potential antitumor activity of microencapsulated Lactobacillus acidophilus yogurt formulation in the attenuation of tumorigenesis in Apc(Min\/+) mice","volume":"54","author":"Urbanska","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1110","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1136\/gutjnl-2020-323951","article-title":"Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis","volume":"71","author":"Sugimura","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.addr.2025.115741_bb1115","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.927277","article-title":"Recombinant Bifidobacterium longum carrying Endostatin protein alleviates dextran sodium sulfate-induced colitis and Colon Cancer in rats","volume":"13","author":"Bi","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.addr.2025.115741_bb1120","first-page":"857","article-title":"More protection of Lactobacillus acidophilus than Bifidobacterium bifidum probiotics on Azoxymethane-induced mouse Colon Cancer, probiotics Antimicrob","volume":"11","author":"Agah","year":"2019","journal-title":"Proteins"},{"key":"10.1016\/j.addr.2025.115741_bb1125","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2020.09.003","article-title":"Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting beta-galactosidase","volume":"160","author":"Li","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.addr.2025.115741_bb1130","first-page":"1111","article-title":"Muciniphila suppresses colorectal tumorigenesis by inducing TLR2\/NLRP3-mediated M1-like TAMs, Cancer","volume":"9","author":"Fan","year":"2021","journal-title":"Immunol. Res."},{"key":"10.1016\/j.addr.2025.115741_bb1135","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115741_bb1140","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115741_bb1145","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1136\/gutjnl-2023-329543","article-title":"Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1\/Kyn\/AHR axis","volume":"72","author":"Fong","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.addr.2025.115741_bb1150","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1186\/s12885-020-06904-3","article-title":"Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients","volume":"20","author":"Negarandeh","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb1155","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116895","article-title":"Probiotic supplementation attenuates the aggressiveness of chemically induced colorectal tumor in rats","volume":"237","author":"Genaro","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1160","first-page":"60","article-title":"Probiotic therapy (BIO-THREE) mitigates intestinal microbial imbalance and intestinal damage caused by Oxaliplatin, probiotics Antimicrob","volume":"14","author":"Yuan","year":"2022","journal-title":"Proteins"},{"key":"10.1016\/j.addr.2025.115741_bb1165","article-title":"Correction: amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model","volume":"10","author":"Yeung","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.addr.2025.115741_bb1170","article-title":"Postoperative probiotics administration attenuates gastrointestinal complications and gut microbiota Dysbiosis caused by chemotherapy in colorectal Cancer patients","volume":"15","author":"Huang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.addr.2025.115741_bb1175","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1039\/D0CS00152J","article-title":"Cell primitive-based biomimetic functional materials for enhanced cancer therapy","volume":"50","author":"Luo","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.addr.2025.115741_bb1180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122147","article-title":"A programmable oral bacterial hydrogel for controllable production and release of nanovaccine for tumor immunotherapy","volume":"299","author":"Zhang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.addr.2025.115741_bb1185","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.abc9113","article-title":"Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy","volume":"373","author":"Griffin","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115741_bb1190","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41586-021-04003-2","article-title":"Metabolic modulation of tumours with engineered bacteria for immunotherapy","volume":"598","author":"Canale","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115741_bb1195","doi-asserted-by":"crossref","unstructured":"C.R. Gurbatri, G.A. Radford, L. Vrbanac, J. Im, E.M. Thomas, C. Coker, S.R. Taylor, Y. Jang, A. Sivan, K. Rhee, A.A. Saleh, T. Chien, F. Zandkarimi, I. Lia, T.R.M. Lannagan, T. Wang, J.A. Wright, H. Kobayashi, J.Q. Ng, M. Lawrence, T. Sammour, M. Thomas, M. Lewis, L. Papanicolas, J. Perry, T. Fitzsimmons, P. Kaazan, A. Lim, A.M. Stavropoulos, D.A. Gouskos, J. Marker, C. Ostroff, G. Rogers, N. Arpaia, D.L. Worthley, S.L. Woods, T. Danino, Engineering tumor-colonizing E. coli Nissle 1917 For detection and treatment of colorectal neoplasia, Nat. Commun., 15 (2024) 646.","DOI":"10.1038\/s41467-024-44776-4"},{"key":"10.1016\/j.addr.2025.115741_bb1200","doi-asserted-by":"crossref","first-page":"2414994","DOI":"10.1002\/adfm.202414994","article-title":"An Oral Nanovaccine secreted by genetically engineered and ultrasound-responsive Bacteria for Colon Cancer immunotherapy","volume":"35","author":"Li","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.addr.2025.115741_bb1205","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The international scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb1210","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.7150\/thno.54476","article-title":"Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumor-bearing mice humanized with gut microbiota from patients with colorectal cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.addr.2025.115741_bb1215","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14302","article-title":"The potential role of prebiotics, probiotics, and synbiotics in adjuvant cancer therapy especially colorectal cancer","volume":"46","author":"Alam","year":"2022","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.addr.2025.115741_bb1220","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.aaz7015","article-title":"Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response","volume":"374","author":"Spencer","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.addr.2025.115741_bb1225","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/s41551-021-00749-2","article-title":"Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel","volume":"5","author":"Han","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.addr.2025.115741_bb1230","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1016\/j.cell.2021.09.019","article-title":"Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment","volume":"184","author":"Lam","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115741_bb1235","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1016\/j.apsb.2025.05.040","article-title":"Improved prebiotic-based \"shield\" equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota","volume":"15","author":"Wang","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.addr.2025.115741_bb1240","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature18930","article-title":"Synchronized cycles of bacterial lysis for in vivo delivery","volume":"536","author":"Din","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115741_bb1245","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41586-024-07182-w","article-title":"A distinct fusobacterium nucleatum clade dominates the colorectal cancer niche","volume":"628","author":"Zepeda-Rivera","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115741_bb1250","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41551-019-0423-2","article-title":"Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy","volume":"3","author":"Zheng","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.addr.2025.115741_bb1255","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.chom.2025.05.004","article-title":"Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity","volume":"33","author":"Ding","year":"2025","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.addr.2025.115741_bb1260","article-title":"Antimicrobial silver in medicinal and consumer applications: A patent review of the past decade (2007(\u2212)2017)","volume":"7","author":"Sim","year":"2018","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.addr.2025.115741_bb1265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137202","article-title":"Silver nanoparticles and their antibacterial applications","volume":"22","author":"Bruna","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.addr.2025.115741_bb1270","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13071000","article-title":"Antitumor activity against human colorectal adenocarcinoma of silver nanoparticles: influence of [ag]\/[PVP] ratio","volume":"13","author":"Cruz-Ramirez","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb1275","first-page":"740","article-title":"Characterization of biosynthesized silver nanoparticles using Lactobacillus rhamnosus GG and its in vitro assessment against colorectal Cancer cells, probiotics Antimicrob","volume":"12","author":"Aziz Mousavi","year":"2020","journal-title":"Proteins"},{"key":"10.1016\/j.addr.2025.115741_bb1280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140748","article-title":"Synthesis of magnetic bio-nanocomposite hydrogel beads based on sodium alginate and beta-cyclodextrin: potential pH-responsive oral delivery anticancer systems for colorectal cancer","volume":"305","author":"Tahmasebi","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.addr.2025.115741_bb1285","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s12668-021-00905-7","article-title":"Green synthesis, characterization and in vivo evaluation of White tea silver nanoparticles with 5-fluorouracil on colorectal Cancer","volume":"11","author":"David","year":"2021","journal-title":"BioNanoScience"},{"key":"10.1016\/j.addr.2025.115741_bb1290","doi-asserted-by":"crossref","first-page":"eaba1590","DOI":"10.1126\/sciadv.aba1590","article-title":"Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer","volume":"6","author":"Dong","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115741_bb1295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-023-00432-7","article-title":"Young-onset colorectal cancer","volume":"9","author":"Spaander","year":"2023","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.addr.2025.115741_bb1300","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156034","article-title":"Gut microbiome and colorectal cancer: from pathogenesis to treatment","volume":"271","author":"Lahouty","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.addr.2025.115741_bb1305","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1038\/s41467-022-31171-0","article-title":"Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb1310","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41565-023-01346-x","article-title":"Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis","volume":"18","author":"Cao","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb1315","doi-asserted-by":"crossref","first-page":"eabb1952","DOI":"10.1126\/sciadv.abb1952","article-title":"Bioinspired oral delivery of gut microbiota by self-coating with biofilms","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115741_bb1320","doi-asserted-by":"crossref","first-page":"7808","DOI":"10.1038\/s41467-022-35579-6","article-title":"Chemical reaction-mediated covalent localization of bacteria","volume":"13","author":"Luo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb1325","article-title":"Advances in polysaccharide-based Oral Colon-targeted delivery systems: the journey so far and the road ahead","volume":"15","author":"Ibrahim","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.addr.2025.115741_bb1330","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jconrel.2024.05.002","article-title":"Orally available dextran-aspirin nanomedicine modulates gut inflammation and microbiota homeostasis for primary colorectal cancer therapy","volume":"370","author":"Ma","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2025.115741_bb1335","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1038\/s41467-023-40439-y","article-title":"Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy","volume":"14","author":"Lang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115741_bb1340","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13081311","article-title":"Review: continuous manufacturing of small molecule solid Oral dosage forms","volume":"13","author":"Wahlich","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.addr.2025.115741_bb1345","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114220","article-title":"Personalised oral dosage forms using an ultra-compact tablet press at the point of care","volume":"197","author":"Krause","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.addr.2025.115741_bb1350","doi-asserted-by":"crossref","DOI":"10.3390\/gels10100620","article-title":"Engineering 3D printed gummies loaded with metformin for Paediatric use","volume":"10","author":"Santamaria","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.addr.2025.115741_bb1355","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41577-023-00973-8","article-title":"Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations","volume":"24","author":"Butterfield","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.addr.2025.115741_bb1360","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41575-019-0126-x","article-title":"Immunotherapy in colorectal cancer: rationale, challenges and potential","volume":"16","author":"Ganesh","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.addr.2025.115741_bb1365","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/s43018-022-00468-w","article-title":"The cGAS-STING pathway and cancer","volume":"3","author":"Samson","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb1370","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.addr.2025.115741_bb1375","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41587-021-01024-0","article-title":"Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors","volume":"40","author":"Abramson","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115741_bb1380","doi-asserted-by":"crossref","first-page":"eabk1792","DOI":"10.1126\/sciadv.abk1792","article-title":"Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery","volume":"8","author":"Chen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115741_bb1385","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41467-017-00144-z","article-title":"Triggerable tough hydrogels for gastric resident dosage forms","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:53:15Z","timestamp":1781167995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X25002261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":277,"alternative-id":["S0169409X25002261"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2025.115741","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2025.115741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115741"}}