{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:59:45Z","timestamp":1790935185211,"version":"4.1.0"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["812865"],"award-info":[{"award-number":["812865"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.addr.2025.115766","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:11:47Z","timestamp":1766247107000},"page":"115766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Genetic engineering approaches in stem and somatic cells for the generation of insulin-producing \u03b2-cells"],"prefix":"10.1016","volume":"230","author":[{"given":"Abiramy","family":"Jeyagaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Schenke-Layland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.addr.2025.115766_bb0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/d41586-024-04160-0","article-title":"Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson\u2019s disease could soon be here","volume":"637","author":"Abbott","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0015","unstructured":"Williams, R. & Colagiuri, S. IDF Diabetes Atlas - Ninth Edition. http:\/\/www.diabetesatlas.org (2019)."},{"key":"10.1016\/j.addr.2025.115766_bb0020","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.2337\/dc14-S081","volume":"37","author":"Diagnosis and Classification of Diabetes Mellitus","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.addr.2025.115766_bb0025","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1210\/jc.2013-1589","article-title":"Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry","volume":"98","author":"Weinstock","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0030","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/ds18-0091","article-title":"A clinical overview of insulin pump therapy for the management of diabetes: Past, present, and future of intensive therapy","volume":"32","author":"Berget","year":"2019","journal-title":"Diabetes Spectr."},{"key":"10.1016\/j.addr.2025.115766_bb0035","series-title":"Pancreas and islet transplantation in diabetes mellitus","author":"Robertson","year":"2019"},{"key":"10.1016\/j.addr.2025.115766_bb0040","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.transproceed.2004.04.050","article-title":"Development of a novel digestion chamber for human and porcine islet isolation","volume":"36","author":"Gray","year":"2004","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.addr.2025.115766_bb0045","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrendo.2016.178","article-title":"Clinical pancreatic islet transplantation","volume":"13","author":"Shapiro","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.addr.2025.115766_bb0050","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0055","doi-asserted-by":"crossref","first-page":"9451492","DOI":"10.1155\/2016\/9451492","article-title":"Pluripotent Stem Cells: Current Understanding and Future Directions","volume":"2016","author":"Romito","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.addr.2025.115766_bb0060","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.stem.2007.11.013","article-title":"The First Direct Reprogramming of Adult Human Fibroblasts","volume":"1","author":"Wilmut","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nbt1374","article-title":"Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts","volume":"26","author":"Nakagawa","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0070","doi-asserted-by":"crossref","unstructured":"Yu, J. et al. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science (80-. ). 318, 1917\u20131920 (2007).","DOI":"10.1126\/science.1151526"},{"key":"10.1016\/j.addr.2025.115766_bb0075","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCRESAHA.118.313425","article-title":"Not All Stem Cells Are Created Equal","volume":"123","author":"Johnston","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.addr.2025.115766_bb0080","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm.3653","article-title":"Preparing the ground for tissue regeneration: from mechanism to therapy","volume":"20","author":"Forbes","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0085","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s11892-012-0292-5","article-title":"Potential of Pluripotent Stem Cells for Diabetes Therapy","volume":"12","author":"Schroeder","year":"2012","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114481","article-title":"Type 1 diabetes and engineering enhanced islet transplantation","volume":"189","author":"Jeyagaran","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.addr.2025.115766_bb0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s13287-022-02977-y","article-title":"Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges","volume":"13","author":"Silva","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109084","article-title":"Cell therapy research for Diabetes: Pancreatic \u03b2 cell differentiation from pluripotent stem cells","volume":"181","author":"Nihad","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.addr.2025.115766_bb0105","article-title":"Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells","volume":"99","author":"Sui","year":"2018","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.addr.2025.115766_bb0110","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","article-title":"Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells","volume":"32","author":"Rezania","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of Functional Human Pancreatic \u03b2 Cells In Vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0120","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41556-018-0271-4","article-title":"Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived beta cells","volume":"21","author":"Nair","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0125","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1038\/s41467-021-23525-x","article-title":"Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional beta cells","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115766_bb0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1900\/RDS.2014.11.19","article-title":"In vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors","volume":"11","author":"Chmielowiec","year":"2014","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.addr.2025.115766_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107623","article-title":"Glucose response by stem cell-derived beta cells in vitro is inhibited by a bottleneck in glycolysis","volume":"31","author":"Davis","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cmet.2007.02.008","article-title":"Mitochondrial GTP regulates glucose-stimulated insulin secretion","volume":"5","author":"Kibbey","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nbt.2141","article-title":"Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3","volume":"30","author":"Blum","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0150","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1101\/gad.294389.116","article-title":"All mixed up- defining roles for \u03b2-cell subtypes in mature islets","volume":"31","author":"Liu","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2025.115766_bb0155","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41587-022-01219-z","article-title":"Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells","volume":"40","author":"Balboa","year":"2022","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.addr.2025.115766_bb0160","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41586-019-1168-5","article-title":"Charting cellular identity during human in vitro beta-cell differentiation","volume":"569","author":"Veres","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0165","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1073\/pnas.1400709111","article-title":"Differentiated human stem cells resemble fetal, not adult, \u03b2 cells","volume":"111","author":"Hrvatin","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2025.115766_bb0170","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1530\/JOE-17-0516","article-title":"Mechanisms of \u03b2-cell dedifferentiation in diabetes: recent findings and future research directions","volume":"236","author":"Bensellam","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.addr.2025.115766_bb0175","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devcel.2007.06.001","article-title":"A Multipotent Progenitor Domain Guides Pancreatic Organogenesis","volume":"13","author":"Zhou","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0185","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/s41467-022-29588-8","article-title":"Generation of human islet cell type-specific identity genesets","volume":"13","author":"van Gurp","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115766_bb0190","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dvdy.10460","article-title":"Gene regulatory factors in pancreatic development","volume":"229","author":"Jensen","year":"2004","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.addr.2025.115766_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1091757","article-title":"PDX1 is the cornerstone of pancreatic \u03b2-cell functions and identity","volume":"9","author":"Ebrahim","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.addr.2025.115766_bb0200","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13287-017-0694-z","article-title":"PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration","volume":"8","author":"Zhu","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0205","article-title":"The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.addr.2025.115766_bb0210","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1242\/dev.120063","article-title":"Human pancreas development","volume":"142","author":"Jennings","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.addr.2025.115766_bb0215","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.2337\/db12-1479","article-title":"Development of the Human Pancreas From Foregut to Endocrine Commitment","volume":"62","author":"Jennings","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0220","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.mod.2011.12.004","article-title":"Fate maps of ventral and dorsal pancreatic progenitor cells in early somite stage mouse embryos","volume":"128","author":"Miki","year":"2012","journal-title":"Mech. Dev."},{"key":"10.1016\/j.addr.2025.115766_bb0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molmet.2018.01.011","article-title":"Genome-wide analysis of PDX1 target genes in human pancreatic progenitors","volume":"9","author":"Wang","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0230","doi-asserted-by":"crossref","first-page":"S320","DOI":"10.2337\/diabetes.51.2007.S320","article-title":"Regulation of pdx-1 Gene Expression","volume":"51","author":"Melloul","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0235","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1101\/gad.12.11.1705","article-title":"Notochord repression of endodermal Sonic hedgehog permits pancreas development","volume":"12","author":"Hebrok","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2025.115766_bb0240","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.devcel.2010.05.015","article-title":"Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors","volume":"18","author":"Schaffer","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0245","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ydbio.2008.01.011","article-title":"Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells","volume":"316","author":"Burlison","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0250","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1172\/JCI37028","article-title":"The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice","volume":"119","author":"Oliver-Krasinski","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2025.115766_bb0255","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","article-title":"Expression of neurogenin3 reveals an islet cell precursor population in the pancreas","volume":"127","author":"Schwitzgebel","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.addr.2025.115766_bb0260","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0012-1606(72)90083-8","article-title":"An ultrastructural analysis of the developing embryonic pancreas","volume":"29","author":"Pictet","year":"1972","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0265","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1002\/dvdy.21740","article-title":"Biphasic Ngn3 expression in the developing pancreas","volume":"237","author":"Villasenor","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.addr.2025.115766_bb0270","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.devcel.2007.02.010","article-title":"Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types","volume":"12","author":"Johansson","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0275","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2025.115766_bb0280","doi-asserted-by":"crossref","unstructured":"Sander, M. et al. Homeobox gene Nkx6. 1 lies downstream of Nkx2. 2 in the major pathway of \u03b2-cell formation in the pancreas. Development 127, 5533\u20135540 (2000).","DOI":"10.1242\/dev.127.24.5533"},{"key":"10.1016\/j.addr.2025.115766_bb0285","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/386399a0","article-title":"The Pax4 gene is essential for differentiation of insulin-producing \u03b2-cells in the mammalian pancreas","volume":"386","author":"Beatriz Sosa-Pineda","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0290","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1242\/dev.01870","article-title":"The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas","volume":"132","author":"Collombat","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.addr.2025.115766_bb0295","doi-asserted-by":"crossref","first-page":"8272","DOI":"10.1128\/MCB.19.12.8272","article-title":"Paired-Homeodomain Transcription Factor PAX4 Acts as a Transcriptional Repressor in Early Pancreatic Development","volume":"19","author":"Smith","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0300","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/386399a0","article-title":"The Pax4 gene is essential for differentiation of insulin-producing \u03b2 cells in the mammalian pancreas","volume":"386","author":"Sosa-Pineda","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0305","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1074\/jbc.M210801200","article-title":"The Islet \u0946 Cell-enriched RIPE3b1\/Maf Transcription Factor Regulates pdx-1 Expression","volume":"278","author":"Samaras","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2025.115766_bb0310","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ydbio.2006.02.028","article-title":"A switch from MafB to MafA expression accompanies differentiation to pancreatic \u03b2-cells","volume":"293","author":"Nishimura","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0315","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ydbio.2009.06.029","article-title":"Expression of MafA in pancreatic progenitors is detrimental for pancreatic development","volume":"333","author":"Nishimura","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0320","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ydbio.2008.10.024","article-title":"Developmental biology of the pancreas: A comprehensive review","volume":"326","author":"Gittes","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0325","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1128\/MCB.25.12.4969-4976.2005","article-title":"MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion","volume":"25","author":"Zhang","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0330","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00125-010-2026-z","article-title":"Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells","volume":"54","author":"Aguayo-Mazzucato","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2025.115766_bb0335","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ydbio.2013.10.024","article-title":"Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA","volume":"385","author":"Hu He","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024058","article-title":"Pdx1 and Ngn3 Overexpression Enhances Pancreatic Differentiation of Mouse ES Cell-Derived Endoderm Population","volume":"6","author":"Kubo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0345","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12967-016-1097-0","article-title":"Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors","volume":"14","author":"Walczak","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0350","first-page":"874","article-title":"PAX4 promotes PDX1-induced differentiation of mesenchymal stem cells into insulin-secreting cells","volume":"9","author":"Xu","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.addr.2025.115766_bb0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134677","article-title":"Adult Human Biliary Tree Stem Cells Differentiate to \u03b2-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide","volume":"10","author":"Cardinale","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0360","doi-asserted-by":"crossref","first-page":"30208","DOI":"10.1074\/jbc.M204202200","article-title":"Efficiency of Protein Transduction Is Cell Type-dependent and Is Enhanced by Dextran Sulfate","volume":"277","author":"Mai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2025.115766_bb0365","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1038\/ncomms11247","article-title":"A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells","volume":"7","author":"Saxena","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115766_bb0370","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jbiotec.2017.07.018","article-title":"Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network","volume":"259","author":"Saxena","year":"2017","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0375","doi-asserted-by":"crossref","first-page":"13608","DOI":"10.1038\/s41598-024-64346-4","article-title":"Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA","volume":"14","author":"Jeyagaran","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0380","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40139-015-0068-0","article-title":"Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes","volume":"3","author":"Cavelti-Weder","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082424","article-title":"Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA","volume":"8","author":"Akinci","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/STJ-200003","article-title":"Transdifferentiation Meets Next-generation Biotechnologies","volume":"4","author":"Ke","year":"2022","journal-title":"StemJ"},{"key":"10.1016\/j.addr.2025.115766_bb0395","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI66514","article-title":"Epigenomic plasticity enables human pancreatic \u03b1 to \u03b2 cell reprogramming","volume":"123","author":"Bramswig","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2025.115766_bb0400","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.2337\/db12-1001","article-title":"Conversion of mature human beta-cells into glucagon-producing alpha-cells","volume":"62","author":"Spijker","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0405","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1101\/gad.16875711","article-title":"Context-specific \u03b1-to-\u03b2-cell reprogramming by forced Pdx1 expression","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2025.115766_bb0410","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4161\/isl.1.3.9779","article-title":"Expression and function of Set7\/9 in pancreatic islets","volume":"1","author":"Ogihara","year":"2009","journal-title":"Islets"},{"key":"10.1016\/j.addr.2025.115766_bb0415","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2337\/db08-1150","article-title":"Methyltransferase Set7\/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes","volume":"58","author":"Deering","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0420","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2009.05.035","article-title":"The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into \u03b1 and Subsequently \u03b2 Cells","volume":"138","author":"Collombat","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0425","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2007.12.015","article-title":"\u03b2 Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas","volume":"132","author":"Xu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0430","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.2337\/db12-1256","article-title":"Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing \u03b2-like cells","volume":"62","author":"Lima","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156204","article-title":"Generation of Functional Beta-Like Cells from Human Exocrine Pancreas","volume":"11","author":"Lima","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0440","doi-asserted-by":"crossref","unstructured":"Akinci, E., Banga, A., Greder, L. V., Dutton, J. R. & Slack, J. M. W. Reprogramming of pancreatic exocrine cells towards a beta (\u03b2) cell character using Pdx1, Ngn3 and MafA. Biochem. J. 442, 539\u2013550 (2012).","DOI":"10.1042\/BJ20111678"},{"key":"10.1016\/j.addr.2025.115766_bb0445","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035626","article-title":"Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas","volume":"12","author":"Ruzittu","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0450","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1201701109","article-title":"In vivo reprogramming of Sox9 + cells in the liver to insulin-secreting ducts","volume":"109","author":"Banga","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.addr.2025.115766_bb0455","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"Ferber","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0460","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.devcel.2009.01.012","article-title":"Neurogenin3 Is Sufficient for Transdetermination of Hepatic Progenitor Cells into Neo-Islets In Vivo but Not Transdifferentiation of Hepatocytes","volume":"16","author":"Yechoor","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0465","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.mt.6300032","article-title":"Adenovirus Transduction is Required for the Correction of Diabetes Using Pdx-1 or Neurogenin-3 in the Liver","volume":"15","author":"Wang","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0470","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1530\/JOE-12-0033","article-title":"In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic \u03b2 cells","volume":"214","author":"Cim","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.addr.2025.115766_bb0475","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.celrep.2014.02.013","article-title":"De novo formation of insulin-producing \u2018neo-\u03b2 cell islets\u2019 from intestinal crypts","volume":"6","author":"Chen","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0480","first-page":"139","article-title":"Reprogrammed Stomach Tissue as a Renewable Source of Functional \u03b2 Cells for Blood Glucose Regulation","volume":"176","author":"Ariyachet","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0485","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.devcel.2009.02.010","article-title":"Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2","volume":"16","author":"Gao","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0490","doi-asserted-by":"crossref","unstructured":"Talchai, C., Xuan, S., Kitamura, T., DePinho, R. A. & Accili, D. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat. Genet. 44, 406\u201312, S1 (2012).","DOI":"10.1038\/ng.2215"},{"key":"10.1016\/j.addr.2025.115766_bb0495","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1210\/en.2004-0051","article-title":"Minireview: Development and Differentiation of Gut Endocrine Cells","volume":"145","author":"Schonhoff","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.addr.2025.115766_bb0500","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1038\/ncomms5242","article-title":"FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures","volume":"5","author":"Bouchi","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2025.115766_bb0505","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.scr.2013.02.005","article-title":"Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming","volume":"11","author":"Hickey","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.addr.2025.115766_bb0510","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41556-023-01130-y","article-title":"Stomach-derived human insulin-secreting organoids restore glucose homeostasis","volume":"25","author":"Huang","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-023-04627-2","article-title":"Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors","volume":"6","author":"Fontcuberta-PiSunyer","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0520","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.stem.2023.04.002","article-title":"Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes","volume":"30","author":"Hogrebe","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0525","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1016\/j.cell.2024.09.004","article-title":"Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient","volume":"187","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0530","doi-asserted-by":"crossref","unstructured":"Reichman, T. W. et al. Stem Cell\u2013Derived, Fully Differentiated Islets for Type 1 Diabetes. N. Engl. J. Med. (2025) doi:https:\/\/doi.org\/10.1056\/NEJMoa2506549.","DOI":"10.1056\/NEJMoa2506549"},{"key":"10.1016\/j.addr.2025.115766_bb0535","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41586-022-04593-5","article-title":"Chemical reprogramming of human somatic cells to pluripotent stem cells","volume":"605","author":"Guan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.addr.2025.115766_bb0540","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41591-021-01645-7","article-title":"Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates","volume":"28","author":"Du","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0545","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s42255-022-00713-7","article-title":"Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets","volume":"5","author":"Liang","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0550","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0555","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.2337\/dc21-2688","article-title":"Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: The CIT-08 Study","volume":"45","author":"Rickels","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.addr.2025.115766_bb0560","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2503822","article-title":"Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression","author":"Carlsson","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0565","unstructured":"Sana Biotechnology Inc. Sana Biotechnology Announces Publication in New England Journal of Medicine of Groundbreaking Clinical Data from Transplantation Without Immunosuppression of Hypoimmune-Modified, Insulin- Producing Islet Cells in Patient with Type 1 Diabetes. (2025)."},{"key":"10.1016\/j.addr.2025.115766_bb0570","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adg5794","article-title":"Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice","volume":"15","author":"Hu","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0575","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.stem.2024.02.001","article-title":"Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate","volume":"31","author":"Hu","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0580","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/labinvest.2010.124","article-title":"Quantitative analysis of cell composition and purity of human pancreatic islet preparations","volume":"90","author":"Pisania","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.addr.2025.115766_bb0585","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/s41591-024-03478-6","article-title":"Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies","volume":"31","author":"Jadlowsky","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0590","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41587-023-01784-x","article-title":"Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques","volume":"42","author":"Hu","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0595","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41587-019-0016-3","article-title":"Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients","volume":"37","author":"Deuse","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.addr.2025.115766_bb0600","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2014.00241","article-title":"Suicide genes: monitoring cells in patients with a safety switch","volume":"5","author":"Eissenberg","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.addr.2025.115766_bb0605","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jcyt.2024.03.484","article-title":"Synthetic biology approaches for enhancing safety and specificity of CAR-T cell therapies for solid cancers","volume":"26","author":"Russell","year":"2024","journal-title":"Cytotherapy"},{"key":"10.1016\/j.addr.2025.115766_bb0610","unstructured":"Genprex. Genprex Collaborators Present Positive Preclinical Research on Diabetes Gene Therapy at the 2025 American Diabetes Association 85th Scientific. https:\/\/www.genprex.com\/2025\/06\/24\/genprex-collaborators-present-positive-preclinical-research-on-diabetes-gene-therapy-at-the-2025-american-diabetes-association-85th-scientific-sessions\/ (2025)."},{"key":"10.1016\/j.addr.2025.115766_bb0615","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2014.183","article-title":"Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and\/or cell-tagging dyes","volume":"9","author":"Xiao","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.addr.2025.115766_bb0620","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.stem.2017.11.020","article-title":"Endogenous reprogramming of alpha cells into beta cells, induced by viral gene therapy, reverses autoimmune diabetes","volume":"22","author":"Xiao","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.addr.2025.115766_bb0625","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-021-00487-6","article-title":"Viral vector platforms within the gene therapy landscape","volume":"6","author":"Bulcha","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0630","doi-asserted-by":"crossref","DOI":"10.3390\/v13081526","article-title":"Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases","volume":"13","author":"Poletti","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.addr.2025.115766_bb0635","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.bbamcr.2017.04.017","article-title":"Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences","volume":"1864","author":"Cie\u015blar-Pobuda","year":"2017","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res."},{"key":"10.1016\/j.addr.2025.115766_bb0640","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/brv.12349","article-title":"Pathways governing development of stem cell-derived pancreatic \u03b2 cells: lessons from embryogenesis","volume":"93","author":"Al-Khawaga","year":"2018","journal-title":"Biol. Rev."},{"key":"10.1016\/j.addr.2025.115766_bb0645","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ydbio.2005.10.001","article-title":"Endodermal expression of Nkx6 genes depends differentially on Pdx1","volume":"288","author":"Pedersen","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0650","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s13287-020-01977-0","article-title":"NKX6.1 transcription factor: a crucial regulator of pancreatic \u03b2 cell development, identity, and proliferation","volume":"11","author":"Aigha","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003274","article-title":"Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity","volume":"9","author":"Schaffer","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.addr.2025.115766_bb0660","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.celrep.2013.08.010","article-title":"Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells","volume":"4","author":"Taylor","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0665","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1083\/jcb.200405148","article-title":"The diabetes-linked transcription factor PAX4 promotes \u03b2-cell proliferation and survival in rat and human islets","volume":"167","author":"Brun","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0670","doi-asserted-by":"crossref","first-page":"15672","DOI":"10.1038\/srep15672","article-title":"PAX4 Defines an Expandable \u03b2-Cell Subpopulation in the Adult Pancreatic Islet","volume":"5","author":"Lorenzo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.addr.2025.115766_bb0675","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molmet.2014.01.010","article-title":"Islet cell plasticity and regeneration","volume":"3","author":"Migliorini","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0680","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/mt.2015.181","article-title":"PAX4 Gene Transfer Induces \u03b1-to-\u03b2 Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.addr.2025.115766_bb0685","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s125-002-8249-9","article-title":"The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6","volume":"45","author":"Ritz-Laser","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.addr.2025.115766_bb0690","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1172\/JCI88015","article-title":"PAX6 maintains \u03b2 cell identity by repressing genes of alternative islet cell types","volume":"127","author":"Swisa","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2025.115766_bb0695","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ydbio.2004.01.040","article-title":"Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes","volume":"269","author":"Ashery-Padan","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.addr.2025.115766_bb0700","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1074\/jbc.M117.784629","article-title":"The transcription factor Pax6 is required for pancreatic \u03b2 cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice","volume":"292","author":"Mitchell","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.addr.2025.115766_bb0705","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1101\/gad.269003","article-title":"Opposing actions of Arx and Pax4 in endocrine pancreas development","volume":"17","author":"Collombat","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.addr.2025.115766_bb0710","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144100","article-title":"The Role of ARX in Human Pancreatic Endocrine Specification","volume":"10","author":"Gage","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0715","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2337\/db10-0573","article-title":"Production of Functional Glucagon-Secreting \u03b1-Cells From Human Embryonic Stem Cells","volume":"60","author":"Rezania","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.addr.2025.115766_bb0720","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cmet.2017.01.009","article-title":"Converting Adult Pancreatic Islet \u03b1 Cells into \u03b2 Cells by Targeting Both Dnmt1 and Arx","volume":"25","author":"Chakravarthy","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.addr.2025.115766_bb0725","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.diff.2010.05.003","article-title":"Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation","volume":"80","author":"Itoh","year":"2010","journal-title":"Differentiation"},{"key":"10.1016\/j.addr.2025.115766_bb0730","article-title":"Pancreatic \u03b1-Cell Specific Deletion of Mouse Arx Leads to \u03b1-Cell Identity Loss","volume":"8","author":"Wilcox","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2025.115766_bb0735","doi-asserted-by":"crossref","first-page":"1134478","DOI":"10.3389\/fendo.2023.1134478","article-title":"EpiCRISPR targeted methylation of Arx gene initiates transient switch of mouse pancreatic alpha to insulin-producing cells","volume":"Lausanne). 14","author":"\u0110or\u0111evi\u0107","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.addr.2025.115766_bb0740","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI29115","article-title":"Embryonic endocrine pancreas and mature \u03b2 cells acquire \u03b1 and PP cell phenotypes upon Arx misexpression","volume":"117","author":"Collombat","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.addr.2025.115766_bb0745","first-page":"67","article-title":"State-of-the-art human gene therapy: part I. Gene delivery technologies","volume":"18","author":"Wang","year":"2014","journal-title":"Discov. Med."},{"key":"10.1016\/j.addr.2025.115766_bb0750","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gendis.2017.04.001","article-title":"Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine","volume":"4","author":"Lee","year":"2017","journal-title":"Genes Dis."},{"key":"10.1016\/j.addr.2025.115766_bb0755","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1038\/s41467-022-29646-1","article-title":"Human pancreatic microenvironment promotes beta-cell differentiation via non-canonical WNT5A\/JNK and BMP signaling","volume":"13","author":"Chmielowiec","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X25002510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:31:50Z","timestamp":1782189110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X25002510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":151,"alternative-id":["S0169409X25002510"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2025.115766","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic engineering approaches in stem and somatic cells for the generation of insulin-producing \u03b2-cells","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2025.115766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115766"}}