{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:54:33Z","timestamp":1788630873431,"version":"build-2803163510"},"reference-count":248,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advanced Drug Delivery Reviews"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.addr.2026.115782","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:22:40Z","timestamp":1769098960000},"page":"115782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Medicinal gases for treating central nervous system injuries"],"prefix":"10.1016","volume":"230","author":[{"given":"Rebecca I.","family":"Sienel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Plesnila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0005","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","volume":"23","year":"2024","journal-title":"Lancet Neurol"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0010","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s12264-022-00959-x","article-title":"Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery","volume":"38","author":"Gao","year":"2022","journal-title":"Neurosci Bull"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/bja\/aem131","article-title":"Pathophysiology of traumatic brain injury","volume":"99","author":"Werner","year":"2007","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0025","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrn1106","article-title":"Mechanisms, challenges and opportunities in stroke","volume":"4","author":"Lo","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuron.2015.05.019","article-title":"Dealing with danger in the CNS: The response of the immune system to injury","volume":"87","author":"Gadani","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.addr.2026.115782_bb0035","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fncel.2019.00528","article-title":"Traumatic brain injuries: pathophysiology and potential therapeutic targets","volume":"13","author":"Ng","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-020-01751-2","article-title":"Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-kappaB signaling pathway and pyroptosis after secondary spinal cord injury","volume":"17","author":"Liu","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-021-00605-6","article-title":"Pharmacological brain cytoprotection in acute ischaemic stroke - renewed hope in the reperfusion era","volume":"18","author":"Fisher","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0050","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sc.2012.137","article-title":"Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture","volume":"51","author":"Lammertse","year":"2013","journal-title":"Spinal Cord"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0060","article-title":"Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury","volume":"5","author":"Martin","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.addr.2026.115782_bb0065","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fimmu.2020.02021","article-title":"Anti-inflammatory and neuroprotective agents in clinical trials for CNS disease and injury: where do we go from here?","volume":"11","author":"Mallah","year":"2020","journal-title":"Front Immunol"},{"issue":"10046","key":"10.1016\/j.addr.2026.115782_bb0070","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(16)30513-X","article-title":"Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study","volume":"388","author":"Kalladka","year":"2016","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.addr.2026.115782_bb0075","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0080","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12264-020-00597-1","article-title":"Neuroprotective Effects of Molecular Hydrogen: A Critical Review","volume":"37","author":"Chen","year":"2021","journal-title":"Neurosci Bull"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0085","doi-asserted-by":"crossref","first-page":"26388","DOI":"10.31083\/JIN26388","article-title":"Effects of Xenon on the Developing Brain: Current Insights from Pre-clinical and Clinical Studies","volume":"24","author":"Shi","year":"2025","journal-title":"J Integr Neurosci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/10715762.2020.1862827","article-title":"Gasotransmitter signaling in energy homeostasis and metabolic disorders","volume":"55","author":"Ali","year":"2021","journal-title":"Free Radic Res"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.acthis.2008.11.004","article-title":"Nervous control of circulation--the role of gasotransmitters, NO, CO, and H2S","volume":"111","author":"Olson","year":"2009","journal-title":"Acta Histochem"},{"key":"10.1016\/j.addr.2026.115782_bb0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnmol.2011.00005","article-title":"Oxygen, a Key Factor Regulating Cell Behavior during Neurogenesis and Cerebral Diseases","volume":"4","author":"Zhang","year":"2011","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0105","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/jnc.15839","article-title":"Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO(2), and pO(2)","volume":"168","author":"DiNuzzo","year":"2024","journal-title":"J Neurochem"},{"issue":"17","key":"10.1016\/j.addr.2026.115782_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179191","article-title":"Hypoxia pathway proteins and their impact on the blood vasculature","volume":"22","author":"Rodriguez","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/jpm12111763","article-title":"Cerebral oxygen delivery and consumption in brain-injured patients","volume":"12","author":"Siwicka-Gieroba","year":"2022","journal-title":"J Pers Med"},{"key":"10.1016\/j.addr.2026.115782_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.729201","article-title":"Nitric oxide pathways in neurovascular coupling under normal and stress conditions in the brain: strategies to rescue aberrant coupling and improve cerebral blood flow","volume":"12","author":"Lourenco","year":"2021","journal-title":"Front Physiol"},{"issue":"15","key":"10.1016\/j.addr.2026.115782_bb0125","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/1381612811319150013","article-title":"Carbon Monoxide and the brain: time to rethink the dogma","volume":"19","author":"Hanafy","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.addr.2026.115782_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9049782","article-title":"Physiological importance of hydrogen sulfide: emerging potent neuroprotector and neuromodulator","volume":"2016","author":"Panthi","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.addr.2026.115782_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1225191","article-title":"The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature","volume":"17","author":"McGuigan","year":"2023","journal-title":"Front Neurosci"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/biom14030305","article-title":"Understanding the Pathophysiology of Ischemic Stroke: The Basis of Current Therapies and Opportunity for New Ones","volume":"14","author":"Salaudeen","year":"2024","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0145","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1570159X17666181227170053","article-title":"NLRP3 Inflammasome in the Pathophysiology of Hemorrhagic Stroke: A Review","volume":"17","author":"Luo","year":"2019","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.33549\/physiolres.934198","article-title":"Impact of perinatal hypoxia on the developing brain","volume":"69","author":"Piesova","year":"2020","journal-title":"Physiol Res"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009394","article-title":"Transport mechanisms at the malaria parasite-host cell interface","volume":"17","author":"Beck","year":"2021","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.addr.2026.115782_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121814","article-title":"Molecular mechanisms of ischemia and glutamate excitotoxicity","volume":"328","author":"Neves","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.addr.2026.115782_bb0165","article-title":"Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke","volume":"4","author":"Bath","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.addr.2026.115782_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.671908","article-title":"The role of mitochondrial dysfunction in vascular disease, tumorigenesis, and diabetes","volume":"8","author":"Zhunina","year":"2021","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.addr.2026.115782_bb0175","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41419-021-04379-z","article-title":"NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke","volume":"13","author":"Bellut","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.addr.2026.115782_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.addr.2026.115782_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112719","article-title":"Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs","volume":"148","author":"Zhu","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.addr.2026.115782_bb0195","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fnins.2019.00085","article-title":"Deciphering the iron side of stroke: neurodegeneration at the crossroads between iron dyshomeostasis, excitotoxicity, and ferroptosis","volume":"13","author":"DeGregorio-Rocasolano","year":"2019","journal-title":"Front Neurosci"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0200","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.addr.2026.115782_bb0205","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1172\/JCI133082","article-title":"Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury","volume":"130","author":"Niatsetskaya","year":"2020","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.addr.2026.115782_bb0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11910-022-01214-6","article-title":"Neurological Complications of Malaria","volume":"22","author":"Trivedi","year":"2022","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"7455","key":"10.1016\/j.addr.2026.115782_bb0215","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12975-016-0495-1","article-title":"Mechanisms of Axonal Damage and Repair after Central Nervous System Injury","volume":"8","author":"Egawa","year":"2017","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.addr.2026.115782_bb0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.expneurol.2013.12.024","article-title":"Functional regeneration beyond the glial scar","volume":"253","author":"Cregg","year":"2014","journal-title":"Exp Neurol"},{"issue":"47","key":"10.1016\/j.addr.2026.115782_bb0230","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.1523\/JNEUROSCI.3240-08.2008","article-title":"Inflammation regulates functional integration of neurons born in adult brain","volume":"28","author":"Jakubs","year":"2008","journal-title":"J Neurosci"},{"issue":"6582","key":"10.1016\/j.addr.2026.115782_bb0235","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm4459","article-title":"Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders","volume":"375","author":"Martin","year":"2022","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0240","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/cercor\/bhab294","article-title":"Human Cerebral Perfusion, Oxygen Consumption, and Lactate Production in Response to Hypoxic Exposure","volume":"32","author":"Vestergaard","year":"2022","journal-title":"Cereb Cortex"},{"issue":"10","key":"10.1016\/j.addr.2026.115782_bb0245","first-page":"2033","article-title":"Should stroke victims routinely receive supplemental oxygen?","volume":"30","author":"Ronning","year":"1999","journal-title":"A quasi-randomized controlled trial. Stroke"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0250","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000530004","article-title":"Normobaric Hyperoxia Combined with Endovascular Treatment in Patients with Acute Ischemic Stroke (OPENS-2) Trial: Protocol for a Prospective, Multicenter","volume":"53","author":"Li","year":"2024","journal-title":"Randomized Controlled Study. Cerebrovasc Dis"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0255","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2045-9912-1-22","article-title":"Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke","volume":"1","author":"Liu","year":"2011","journal-title":"Med Gas Res"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0260","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/STROKEAHA.114.008599","article-title":"Normobaric hyperoxia slows blood-brain barrier damage and expands the therapeutic time window for tissue-type plasminogen activator treatment in cerebral ischemia","volume":"46","author":"Liang","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2026.115782_bb0265","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fneur.2020.00050","article-title":"Advances in Normobaric Hyperoxia Brain Protection in Experimental Stroke","volume":"11","author":"Chen","year":"2020","journal-title":"Front Neurol"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/biom10091279","article-title":"An Extra Breath of Fresh Air: Hyperbaric Oxygenation as a Stroke Therapeutic","volume":"10","author":"Cozene","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0275","doi-asserted-by":"crossref","first-page":"21410","DOI":"10.1038\/s41598-024-72454-4","article-title":"ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice","volume":"14","author":"Guo","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0280","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12883-024-03555-w","article-title":"Efficacy and safety of hyperbaric oxygen therapy in acute ischaemic stroke: a systematic review and meta-analysis","volume":"24","author":"Li","year":"2024","journal-title":"BMC Neurol"},{"key":"10.1016\/j.addr.2026.115782_bb0285","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.928802","article-title":"The application and perspective of hyperbaric oxygen therapy in acute ischemic stroke: From the bench to a starter?","volume":"13","author":"Yan","year":"2022","journal-title":"Front Neurol"},{"issue":"8","key":"10.1016\/j.addr.2026.115782_bb0290","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuint.2003.10.004","article-title":"Hyperbaric oxygen treatment: the influence on the hippocampal superoxide dismutase and Na+,K+-ATPase activities in global cerebral ischemia-exposed rats","volume":"44","author":"Mrsi\u0107-Pelci\u0107","year":"2004","journal-title":"Neurochem Int"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0295","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s10753-018-0843-2","article-title":"Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-\u03baB\/MAPKs-CCL2\/CXCL1 Signaling Pathway in Cultured Astrocytes","volume":"41","author":"Liu","year":"2018","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0300","first-page":"185","article-title":"Neutrophil sequestration and the effect of hyperbaric oxygen in a rat model of temporary middle cerebral artery occlusion","volume":"27","author":"Atochin","year":"2000","journal-title":"Undersea Hyperb Med"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0305","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s11064-020-03219-4","article-title":"Hyperbaric Oxygen Preconditioning Protects Against Cerebral Ischemia\/Reperfusion Injury by Inhibiting Mitochondrial Apoptosis and Energy Metabolism Disturbance","volume":"46","author":"Wang","year":"2021","journal-title":"Neurochem Res"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0310","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1021\/acs.chemrestox.3c00259","article-title":"Molecular Hydrogen: Emerging Treatment for Stroke Management","volume":"36","author":"Kuo","year":"2023","journal-title":"Chem Res Toxicol"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126591","article-title":"Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?","volume":"23","author":"Pluta","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.addr.2026.115782_bb0320","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/s11064-019-02829-x","article-title":"UPLC-QTOF\/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic Stroke","volume":"44","author":"Chen","year":"2019","journal-title":"Neurochem Res"},{"issue":"14","key":"10.1016\/j.addr.2026.115782_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147884","article-title":"The Protective Role of Molecular Hydrogen in Ischemia\/Reperfusion Injury","volume":"25","author":"Kura","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1-2","key":"10.1016\/j.addr.2026.115782_bb0330","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s11481-022-10051-w","article-title":"Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4\/NF-\u03baB Inflammatory Pathway","volume":"18","author":"Yang","year":"2023","journal-title":"J Neuroimmune Pharmacol"},{"key":"10.1016\/j.addr.2026.115782_bb0335","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainres.2018.06.028","article-title":"Hydrogen exerts neuroprotective effects on OGD\/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1\/Parkin signaling pathway","volume":"1698","author":"Wu","year":"2018","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0340","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/2045-9912.359677","article-title":"Molecular hydrogen therapy for neurological diseases: a review of current evidence","volume":"13","author":"Ramanathan","year":"2023","journal-title":"Med Gas Res"},{"issue":"23","key":"10.1016\/j.addr.2026.115782_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28237785","article-title":"Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes","volume":"28","author":"Johnsen","year":"2023","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0350","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.012","article-title":"Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection","volume":"26","author":"Ono","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0355","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/2045-9912.215750","article-title":"The role of nitric oxide in stroke","volume":"7","author":"Chen","year":"2017","journal-title":"Med Gas Res"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0360","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2004.03.009","article-title":"Targeting eNOS for stroke protection","volume":"27","author":"Endres","year":"2004","journal-title":"Trends Neurosci"},{"issue":"23","key":"10.1016\/j.addr.2026.115782_bb0365","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1007\/s00018-015-2021-0","article-title":"Endothelial nitric oxide synthase in the microcirculation","volume":"72","author":"Shu","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"14","key":"10.1016\/j.addr.2026.115782_bb0370","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1523\/JNEUROSCI.19-14-05910.1999","article-title":"Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage","volume":"19","author":"Eliasson","year":"1999","journal-title":"J Neurosci"},{"issue":"3\u20134","key":"10.1016\/j.addr.2026.115782_bb0375","first-page":"401","article-title":"Nitric oxide and peroxynitrite interactions with mitochondria","volume":"383","author":"Radi","year":"2002","journal-title":"Biol Chem"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0380","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1161\/STROKEAHA.115.009647","article-title":"Effect of hyperacute administration (Within 6 Hours) of transdermal glyceryl trinitrate, a nitric oxide donor, on outcome after stroke: subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial","volume":"46","author":"Woodhouse","year":"2015","journal-title":"Stroke"},{"issue":"10175","key":"10.1016\/j.addr.2026.115782_bb0385","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0140-6736(19)30194-1","volume":"393","year":"2019","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0390","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/CIRCRESAHA.111.253419","article-title":"Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles","volume":"110","author":"Terpolilli","year":"2012","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0395","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/jcbfm.2012.12","article-title":"Nitric oxide: considerations for the treatment of ischemic stroke","volume":"32","author":"Terpolilli","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0400","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12974-023-02988-3","article-title":"Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke","volume":"20","author":"Sienel","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0405","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12974-018-1226-1","article-title":"Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption","volume":"15","author":"Wang","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0410","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/2045-9912.337993","article-title":"Devil or angel: two roles of carbon monoxide in stroke","volume":"12","author":"Li","year":"2022","journal-title":"Med Gas Res"},{"key":"10.1016\/j.addr.2026.115782_bb0415","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphys.2015.00033","article-title":"Carbon monoxide and mitochondria-modulation of cell metabolism, redox response and cell death","volume":"6","author":"Almeida","year":"2015","journal-title":"Front Physiol"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0420","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0425","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/STROKEAHA.110.607101","article-title":"Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia","volume":"42","author":"Wang","year":"2011","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0430","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/ALN.0b013e3181cea398","article-title":"Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia","volume":"112","author":"Banks","year":"2010","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0435","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/01.anes.0000287061.77674.71","article-title":"Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology","volume":"107","author":"Dickinson","year":"2007","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0440","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/2045-9912.241077","article-title":"Potential application value of xenon in stroke treatment","volume":"8","author":"Zhao","year":"2018","journal-title":"Med Gas Res"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0445","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ana.20547","article-title":"Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia","volume":"58","author":"Ma","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.addr.2026.115782_bb0450","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jad.2022.01.025","article-title":"Repetitive xenon treatment improves post-stroke sensorimotor and neuropsychiatric dysfunction","volume":"301","author":"Dandekar","year":"2022","journal-title":"J Affect Disord"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0455","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/jcbfm.2009.275","article-title":"Xenon is an inhibitor of tissue-plasminogen activator: adverse and beneficial effects in a rat model of thromboembolic stroke","volume":"30","author":"David","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0460","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bja.2022.04.016","article-title":"Neuroprotection by the noble gases argon and xenon as treatments for acquired brain injury: a preclinical systematic review and meta-analysis","volume":"129","author":"Liang","year":"2022","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0465","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.5114\/aoms.2017.65081","article-title":"The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications","volume":"13","author":"Ostrowski","year":"2017","journal-title":"Arch Med Sci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0470","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12028-014-0013-9","article-title":"Only very early oxygen therapy attenuates posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage","volume":"22","author":"Zhou","year":"2015","journal-title":"Neurocrit Care"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0475","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3892\/etm.2015.2539","article-title":"Effect of hyperbaric oxygen preconditioning on peri-hemorrhagic focal edema and aquaporin-4 expression","volume":"10","author":"Fang","year":"2015","journal-title":"Exp Ther Med"},{"issue":"10","key":"10.1016\/j.addr.2026.115782_bb0480","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/cns.13208","article-title":"Hyperbaric oxygen preconditioning attenuates brain injury after intracerebral hemorrhage by regulating microglia polarization in rats","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.addr.2026.115782_bb0485","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2015.08.011","article-title":"Hyperbaric oxygen preconditioning attenuates neuroinflammation after intracerebral hemorrhage in rats by regulating microglia characteristics","volume":"1627","author":"Yang","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.addr.2026.115782_bb0490","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/978-3-211-85578-2_60","article-title":"Hyperbaric oxygen preconditioning activates ribosomal protein S6 kinases and reduces brain swelling after intracerebral hemorrhage","volume":"102","author":"Qin","year":"2008","journal-title":"Acta Neurochir Suppl"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0495","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/STROKEAHA.116.015753","article-title":"Hyperbaric oxygen reduces infarction volume and hemorrhagic transformation through ATP\/NAD(+)\/Sirt1 pathway in hyperglycemic middle cerebral artery occlusion rats","volume":"48","author":"Hu","year":"2017","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0500","first-page":"93","article-title":"Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients - a retrospective analysis","volume":"38","author":"Hadanny","year":"2020","journal-title":"Restor Neurol Neurosci"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0505","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nm1577","article-title":"Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals","volume":"13","author":"Ohsawa","year":"2007","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0510","doi-asserted-by":"crossref","first-page":"12319","DOI":"10.1038\/s41598-020-69028-5","article-title":"Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after experimental subarachnoid hemorrhage","volume":"10","author":"Kumagai","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0515","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.12998\/wjcc.v10.i4.1311","article-title":"Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral hemorrhage: A case report and literature review","volume":"10","author":"Huang","year":"2022","journal-title":"World J Clin Cases"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0520","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1007\/s12035-015-9242-y","article-title":"Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-\u03baB Pathway and NLRP3 Inflammasome","volume":"53","author":"Shao","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.addr.2026.115782_bb0525","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainresbull.2018.07.006","article-title":"Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model","volume":"142","author":"Choi","year":"2018","journal-title":"Brain Res Bull"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0530","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/STROKEAHA.120.031260","article-title":"Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage","volume":"52","author":"Takeuchi","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2026.115782_bb0535","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fncel.2020.00210","article-title":"Hydrogen Sulfide Reduces Cognitive Impairment in Rats After Subarachnoid Hemorrhage by Ameliorating Neuroinflammation Mediated by the TLR4\/NF-\u03baB Pathway in Microglia","volume":"14","author":"Duan","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.addr.2026.115782_bb0540","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neulet.2016.04.018","article-title":"Hydrogen sulfide attenuates brain edema in early brain injury after subarachnoid hemorrhage in rats: Possible involvement of MMP-9 induced blood-brain barrier disruption and AQP4 expression","volume":"621","author":"Cao","year":"2016","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.addr.2026.115782_bb0545","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fncel.2019.00349","article-title":"Exogenous Hydrogen Sulfide Offers Neuroprotection on Intracerebral Hemorrhage Injury Through Modulating Endogenous H(2)S Metabolism in Mice","volume":"13","author":"Shan","year":"2019","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0550","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/bpa.12361","article-title":"Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage","volume":"27","author":"Li","year":"2017","journal-title":"Brain Pathol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0555","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/toxsci\/65.1.18","article-title":"Cytochrome Oxidase Inhibition Induced by Acute Hydrogen Sulfide Inhalation: Correlation with Tissue Sulfide Concentrations in the Rat Brain, Liver, Lung, and Nasal Epithelium","volume":"65","author":"Dorman","year":"2002","journal-title":"Toxicological Sci."},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0560","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1177\/0271678X15605848","article-title":"Nitric oxide inhalation reduces brain damage, prevents mortality, and improves neurological outcome after subarachnoid hemorrhage by resolving early pial microvasospasms","volume":"36","author":"Terpolilli","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0565","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/STROKEAHA.110.607200","article-title":"Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm","volume":"42","author":"Vellimana","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2026.115782_bb0570","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainres.2014.04.042","article-title":"Blood-brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation","volume":"1571","author":"Ding","year":"2014","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0575","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1007\/s12035-022-02788-5","article-title":"Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation","volume":"59","author":"Qu","year":"2022","journal-title":"Mol Neurobiol"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0580","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1177\/0271678X20973787","article-title":"Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice","volume":"41","author":"Lenz","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0585","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/rccm.200605-662OC","article-title":"Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats","volume":"176","author":"Auten","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0590","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/STROKEAHA.110.600569","article-title":"Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage","volume":"42","author":"Sheng","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2026.115782_bb0595","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.817072","article-title":"Inhaled Nitric Oxide Treatment for Aneurysmal SAH Patients With Delayed Cerebral Ischemia","volume":"13","author":"Fung","year":"2022","journal-title":"Front Neurol"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0600","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/CCM.0b013e31822f0d64","article-title":"CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke","volume":"40","author":"Yabluchanskiy","year":"2012","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0605","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1161\/STROKEAHA.116.016165","article-title":"Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice","volume":"48","author":"Schallner","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.addr.2026.115782_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108117","article-title":"Carbon monoxide attenuates vasospasm and improves neurobehavioral function after subarachnoid hemorrhage","volume":"676","author":"Kamat","year":"2019","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0615","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1172\/JCI78443","article-title":"Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1","volume":"125","author":"Schallner","year":"2015","journal-title":"J Clin Invest"},{"issue":"23","key":"10.1016\/j.addr.2026.115782_bb0620","article-title":"A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI","volume":"3","author":"Fredenburgh","year":"2018","journal-title":"Insight"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb0625","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1097\/CCM.0000000000001561","article-title":"Beneficial Properties of Argon After Experimental Subarachnoid Hemorrhage: Early Treatment Reduces Mortality and Influences Hippocampal Protein Expression","volume":"44","author":"Hollig","year":"2016","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0630","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/2045-9912.296039","article-title":"Argon treatment after experimental subarachnoid hemorrhage: evaluation of microglial activation and neuronal survival as a subanalysis of a randomized controlled animal trial","volume":"10","author":"Kremer","year":"2020","journal-title":"Med Gas Res"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0635","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12028-024-02090-3","article-title":"Effects of Argon in the Acute Phase of Subarachnoid Hemorrhage in an Endovascular Perforation Model in Rats","volume":"42","author":"Krenzlin","year":"2025","journal-title":"Neurocrit Care"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143887","article-title":"Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4","volume":"10","author":"Ulbrich","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.addr.2026.115782_bb0645","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1028688","article-title":"Noble gas and neuroprotection: From bench to bedside","volume":"13","author":"Yin","year":"2022","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0650","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12975-022-01021-8","article-title":"Heliox Preconditioning Exerts Neuroprotective Effects on Neonatal Ischemia\/Hypoxia Injury by Inhibiting Necroptosis Induced by Ca(2+) Elevation","volume":"14","author":"Zhong","year":"2023","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.addr.2026.115782_bb0655","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3389\/fneur.2017.00511","article-title":"Xenon Reduces Neuronal Hippocampal Damage and Alters the Pattern of Microglial Activation after Experimental Subarachnoid Hemorrhage: A Randomized Controlled Animal Trial","volume":"8","author":"Veldeman","year":"2017","journal-title":"Front Neurol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0660","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41598-017-18914-6","article-title":"Delivery of xenon-containing echogenic liposomes inhibits early brain injury following subarachnoid hemorrhage","volume":"8","author":"Miao","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0665","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.bja.2018.08.014","article-title":"Neuroprotective properties of xenon in different types of CNS injury","volume":"121","author":"Van Hese","year":"2018","journal-title":"Br J Anaesth"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0670","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/CCM.0000000000002619","article-title":"Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial","volume":"45","author":"Okonkwo","year":"2017","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0675","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/aas.14019","article-title":"Supplemental oxygen for traumatic brain injury: A systematic review","volume":"66","author":"Hansen","year":"2022","journal-title":"Acta Anaesthesiol Scand"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0680","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archsurg.2012.1560","article-title":"Association between early hyperoxia and worse outcomes after traumatic brain injury","volume":"147","author":"Brenner","year":"2012","journal-title":"Arch Surg"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0685","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3171\/jns.2004.101.3.0435","article-title":"Normobaric hyperoxia--induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study","volume":"101","author":"Tolias","year":"2004","journal-title":"J Neurosurg"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0690","article-title":"Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury","volume":"12","author":"Bennett","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0695","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3171\/2013.2.JNS121468","article-title":"A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury","volume":"118","author":"Rockswold","year":"2013","journal-title":"J Neurosurg"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0700","first-page":"1075","article-title":"Hyperbaric side effects in a traumatic brain injury randomized clinical trial","volume":"39","author":"Wolf","year":"2012","journal-title":"Undersea Hyperb Med"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0705","doi-asserted-by":"crossref","first-page":"217","DOI":"10.22462\/04.06.2020.7","article-title":"Middle-ear barotrauma after hyperbaric oxygen therapy: a five-year retrospective analysis on 2,610 patients","volume":"47","author":"Edinguele","year":"2020","journal-title":"Undersea Hyperb Med"},{"issue":"19","key":"10.1016\/j.addr.2026.115782_bb0710","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1089\/neu.2021.0053","article-title":"Inhalational Gases for Neuroprotection in Traumatic Brain Injury","volume":"38","author":"Shin","year":"2021","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.addr.2026.115782_bb0715","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.brainres.2010.07.038","article-title":"Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress","volume":"1354","author":"Ji","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.addr.2026.115782_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147053","article-title":"Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic brain injury","volume":"1748","author":"Zhao","year":"2020","journal-title":"Brain Res"},{"key":"10.1016\/j.addr.2026.115782_bb0725","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2018.03.024","article-title":"Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway","volume":"228","author":"Yuan","year":"2018","journal-title":"J Surg Res"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0730","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.brainresbull.2012.06.006","article-title":"Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury","volume":"88","author":"Hou","year":"2012","journal-title":"Brain Res Bull"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0735","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108034","article-title":"Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury","volume":"9","author":"Dohi","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0740","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3892\/etm.2021.11049","article-title":"Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS\/HO-1 signaling pathway after traumatic brain injury","volume":"23","author":"Hu","year":"2022","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.addr.2026.115782_bb0745","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1413904","article-title":"Effects of perioperative hydrogen inhalation on brain edema and prognosis in patients with glioma: a single-center, randomized controlled study","volume":"15","author":"Wu","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.addr.2026.115782_bb0750","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7301615","article-title":"Biologic Effect of Hydrogen Sulfide and Its Role in Traumatic Brain Injury","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0755","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087241","article-title":"Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0760","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jss.2013.03.067","article-title":"Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate-sensitive potassium channels and reduction of oxidative stress","volume":"184","author":"Jiang","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.addr.2026.115782_bb0765","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.expneurol.2014.10.017","article-title":"The role of the nitric oxide pathway in brain injury and its treatment--from bench to bedside","volume":"263","author":"Garry","year":"2015","journal-title":"Exp Neurol"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0770","first-page":"1427","article-title":"Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats","volume":"43","author":"Wada","year":"1998","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0775","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1750-3639.2004.tb00053.x","article-title":"Nitric oxide in traumatic brain injury","volume":"14","author":"Cherian","year":"2004","journal-title":"Brain Pathol"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0780","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1089\/neu.2009.0955","article-title":"Hemodynamic and histological effects of traumatic brain injury in eNOS-deficient mice","volume":"26","author":"Lundblad","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.addr.2026.115782_bb0785","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-031-14190-4_1","article-title":"Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury","volume":"1395","author":"Bragin","year":"2022","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0790","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3171\/jns.2003.99.2.0351","article-title":"Upregulation of neurogenesis and reduction in functional deficits following administration of DEtA\/NONOate, a nitric oxide donor, after traumatic brain injury in rats","volume":"99","author":"Lu","year":"2003","journal-title":"J Neurosurg"},{"issue":"25","key":"10.1016\/j.addr.2026.115782_bb0795","article-title":"Sustained release of nitric oxide-mediated angiogenesis and nerve repair by mussel-inspired adaptable microreservoirs for brain traumatic injury therapy","volume":"13","author":"Liu","year":"2024","journal-title":"Adv Healthc Mater"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0800","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/jcbfm.2012.176","article-title":"Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice","volume":"33","author":"Terpolilli","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"issue":"19","key":"10.1016\/j.addr.2026.115782_bb0805","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1089\/neu.2014.3344","article-title":"Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA)","volume":"31","author":"Stover","year":"2014","journal-title":"J Neurotrauma"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0810","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1089\/neu.2008.0853","article-title":"The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice","volume":"26","author":"Terpolilli","year":"2009","journal-title":"J Neurotrauma"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0815","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/bcp.13870","article-title":"Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers","volume":"85","author":"Ott","year":"2019","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb0820","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/nm.4188","article-title":"Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury","volume":"22","author":"Choi","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.addr.2026.115782_bb0825","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113683","article-title":"CORM-3 exerts a neuroprotective effect in a rodent model of traumatic brain injury via the bidirectional gut-brain interactions","volume":"341","author":"Zhang","year":"2021","journal-title":"Exp Neurol"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0830","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1177\/0271678X251314371","article-title":"A-kinase anchor protein 12 promotes oligodendrogenesis and cognitive recovery in carbon monoxide therapy for traumatic brain injury","volume":"45","author":"Choi","year":"2025","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0835","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0840","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/stem.2771","article-title":"A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter","volume":"36","author":"Maki","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.addr.2026.115782_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104784","article-title":"CORM-3 improves emotional changes induced by hemorrhagic shock via the inhibition of pyroptosis in the amygdala","volume":"139","author":"Zhang","year":"2020","journal-title":"Neurochem Int"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb0850","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s11010-024-05130-w","article-title":"Carbon monoxide-releasing molecule-3 ameliorates traumatic brain injury-induced cardiac dysfunctions via inhibition of pyroptosis and apoptosis","volume":"480","author":"Bai","year":"2025","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0855","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/ALN.0b013e3182a2a265","article-title":"Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site","volume":"119","author":"Harris","year":"2013","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0860","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bja.2019.07.010","article-title":"Noble gas neuroprotection: xenon and argon protect against hypoxic-ischaemic injury in rat hippocampus in vitro via distinct mechanisms","volume":"123","author":"Koziakova","year":"2019","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0865","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1186\/s13054-020-03373-9","article-title":"Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study","volume":"24","author":"Campos-Pires","year":"2020","journal-title":"Crit Care"},{"issue":"13-14","key":"10.1016\/j.addr.2026.115782_bb0870","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1089\/neu.2022.0468","article-title":"Brain Targeted Xenon Protects Cerebral Vasculature After Traumatic Brain Injury","volume":"40","author":"Shin","year":"2023","journal-title":"J Neurotrauma"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0875","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bja.2019.02.032","article-title":"Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice","volume":"123","author":"Campos-Pires","year":"2019","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0880","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/CCM.0000000000000624","article-title":"Xenon improves neurologic outcome and reduces secondary injury following trauma in an in vivo model of traumatic brain injury","volume":"43","author":"Campos-Pires","year":"2015","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0885","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/ALN.0000000000001873","article-title":"Effect of Xenon anesthesia compared to sevoflurane and total intravenous anesthesia for coronary artery bypass graft surgery on postoperative cardiac troponin release: an international, multicenter, phase 3, single-blinded, Randomized Noninferiority Trial","volume":"127","author":"Hofland","year":"2017","journal-title":"Anesthesiology"},{"issue":"23","key":"10.1016\/j.addr.2026.115782_bb0890","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312673","article-title":"Positive effects of argon inhalation after traumatic brain injury in rats","volume":"25","author":"Antonova","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0895","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1111\/jnc.13662","article-title":"Argon mediates protection by interleukin-8 suppression via a TLR2\/TLR4\/STAT3\/NF-\u03baB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia-reperfusion injury in rat retina in vivo","volume":"138","author":"Ulbrich","year":"2016","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0900","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bja.2020.08.027","article-title":"Efficacy of acute administration of inhaled argon on traumatic brain injury in mice","volume":"126","author":"Moro","year":"2021","journal-title":"Br J Anaesth"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0905","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s12028-020-01104-0","article-title":"Argon inhalation for 24 h after closed-head injury does not improve recovery, neuroinflammation, or neurologic outcome in mice","volume":"34","author":"Creed","year":"2021","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.addr.2026.115782_bb0910","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pediatrneurol.2018.02.009","article-title":"Xenon Combined With Hypothermia in Perinatal Hypoxic-Ischemic Encephalopathy: A Noble Gas, a Noble Mission","volume":"84","author":"Amer","year":"2018","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.addr.2026.115782_bb0915","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2020.09.030","article-title":"Attenuation of the mutual elevation of iron accumulation and oxidative stress may contribute to the neuroprotective and anti-seizure effects of xenon in neonatal hypoxia-induced seizures","volume":"161","author":"Zhang","year":"2020","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0920","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.STR.0000198867.31134.ac","article-title":"Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia","volume":"37","author":"Dingley","year":"2006","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb0925","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ana.22016","article-title":"Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs","volume":"68","author":"Chakkarapani","year":"2010","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0930","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ana.22387","article-title":"Xenon augmented hypothermia reduces early lactate\/N-acetylaspartate and cell death in perinatal asphyxia","volume":"70","author":"Faulkner","year":"2011","journal-title":"Ann Neurol"},{"issue":"8","key":"10.1016\/j.addr.2026.115782_bb0935","article-title":"Xenon as an adjuvant to therapeutic hypothermia in near-term and term newborns with hypoxic-ischaemic encephalopathy","volume":"8","author":"Ruegger","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0940","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/pr.2015.49","article-title":"Adding 5h delayed xenon to delayed hypothermia treatment improves long-term function in neonatal rats surviving to adulthood","volume":"77","author":"Liu","year":"2015","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb0945","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.2013-0787","article-title":"Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study","volume":"133","author":"Dingley","year":"2014","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0950","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(15)00347-6","article-title":"Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial","volume":"15","author":"Azzopardi","year":"2016","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb0955","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1213\/ANE.0000000000007223","article-title":"Xenon and argon as neuroprotective treatments for perinatal hypoxic-ischemic brain injury: a preclinical systematic review and meta-analysis","volume":"141","author":"Barros","year":"2025","journal-title":"Anesth Analg"},{"key":"10.1016\/j.addr.2026.115782_bb0960","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.nbd.2015.12.001","article-title":"Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia","volume":"87","author":"Broad","year":"2016","journal-title":"Neurobiol Dis"},{"issue":"18","key":"10.1016\/j.addr.2026.115782_bb0965","doi-asserted-by":"crossref","first-page":"25640","DOI":"10.18632\/oncotarget.8241","article-title":"Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of nuclear factor (erythroid-derived 2)-like 2","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb0970","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113575","article-title":"Neuroprotection by argon ventilation after perinatal asphyxia: a safety study in newborn piglets","volume":"9","author":"Alderliesten","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0975","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bja.2020.09.028","article-title":"Argon: a noble, but not inert, treatment for brain trauma?","volume":"126","author":"Edge","year":"2021","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.addr.2026.115782_bb0980","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105143","article-title":"Treatment with inhaled Argon: a systematic review of pre-clinical and clinical studies with meta-analysis on neuroprotective effect","volume":"103","author":"Merigo","year":"2024","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb0985","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1053\/j.semperi.2016.05.007","article-title":"Inhaled nitric oxide therapy for pulmonary disorders of the term and preterm infant","volume":"40","author":"Sokol","year":"2016","journal-title":"Semin Perinatol"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb0990","article-title":"Nitric oxide for respiratory failure in infants born at or near term","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"10.1016\/j.addr.2026.115782_bb0995","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199702273360902","article-title":"Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group","volume":"336","author":"Roberts","year":"1997","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb1000","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.clinthera.2010.04.023","article-title":"Efficacy of inhaled nitric oxide for hypoxic respiratory failure in term and late preterm infants by baseline severity of illness: a pooled analysis of three clinical trials","volume":"32","author":"Golombek","year":"2010","journal-title":"Clin Ther"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb1005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJM200002173420704","article-title":"Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group","volume":"342","author":"Clark","year":"2000","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.addr.2026.115782_bb1010","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1067\/mpd.2000.104826","article-title":"Neurodevelopmental follow-up of the neonatal inhaled nitric oxide study group (NINOS)","volume":"136","author":"Inhaled nitric oxide in term and near-term infants","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.addr.2026.115782_bb1015","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/949361","article-title":"Perinatal nitric oxide therapy prevents adverse effects of perinatal hypoxia on the adult pulmonary circulation","volume":"2014","author":"Peyter","year":"2014","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb1020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1161\/01.RES.76.2.215","article-title":"Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat","volume":"76","author":"Roberts","year":"1995","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb1025","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.RES.87.2.140","article-title":"Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups","volume":"87","author":"Roberts","year":"2000","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.addr.2026.115782_bb1030","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1164\/rccm.200503-384OC","article-title":"Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs","volume":"172","author":"Bland","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"Suppl. 2","key":"10.1016\/j.addr.2026.115782_bb1035","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/jp.2016.43","article-title":"The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy","volume":"36","author":"Lakshminrusimha","year":"2016","journal-title":"J Perinatol"},{"key":"10.1016\/j.addr.2026.115782_bb1040","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.redox.2017.03.011","article-title":"Oxygen and oxidative stress in the perinatal period","volume":"12","author":"Torres-Cuevas","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.addr.2026.115782_bb1045","article-title":"Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art","volume":"24","author":"Chakkarapani","year":"2025","journal-title":"Pediatr Res"},{"key":"10.1016\/j.addr.2026.115782_bb1050","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2007.12.039","article-title":"Mechanism of hyperbaric oxygen preconditioning in neonatal hypoxia-ischemia rat model","volume":"1196","author":"Li","year":"2008","journal-title":"Brain Res"},{"issue":"13","key":"10.1016\/j.addr.2026.115782_bb1055","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4103\/1673-5374.112859","article-title":"Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage","volume":"8","author":"Feng","year":"2013","journal-title":"Neural Regen Res"},{"issue":"12","key":"10.1016\/j.addr.2026.115782_bb1060","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1177\/0963689719883578","article-title":"HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3\/\u03b2-Catenin and BMP2 Signaling Pathways","volume":"28","author":"Chen","year":"2019","journal-title":"Cell Transplant"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb1065","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3109\/10715762.2015.1136411","article-title":"Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia brain damage by activating Nrf2 expression in vivo and in vitro","volume":"50","author":"Zhai","year":"2016","journal-title":"Free Radic Res"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb1070","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1590\/s0102-865020170040000002","article-title":"Effects of hyperbaric oxygen and nerve growth factor on the long-term neural behavior of neonatal rats with hypoxic ischemic brain damage","volume":"32","author":"Wei","year":"2017","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.addr.2026.115782_bb1075","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.707136","article-title":"Efficacy and Prognosis of Hyperbaric Oxygen as Adjuvant Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Meta-Analysis Study","volume":"10","author":"Gong","year":"2022","journal-title":"Front Pediatr"},{"issue":"7564","key":"10.1016\/j.addr.2026.115782_bb1080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/bmj.38776.731655.2F","article-title":"Clinical effectiveness of treatment with hyperbaric oxygen for neonatal hypoxic-ischaemic encephalopathy: systematic review of Chinese literature","volume":"333","author":"Liu","year":"2006","journal-title":"Bmj"},{"key":"10.1016\/j.addr.2026.115782_bb1085","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1386695","article-title":"Hyperbaric oxygen therapy for the treatment of hypoxic\/ischemic injury upon perinatal asphyxia-are we there yet?","volume":"15","author":"Mielecki","year":"2024","journal-title":"Front Neurol"},{"key":"10.1016\/j.addr.2026.115782_bb1090","series-title":"Evidence-Based Hyperbaric Medicine: Concepts and Clinical Application","first-page":"213","article-title":"Complications of Hyperbaric Oxygen Therapy: Oxygen Toxicity","author":"Lopa","year":"2025"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb1095","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.mehy.2011.06.003","article-title":"Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale","volume":"77","author":"Hawkes","year":"2011","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.addr.2026.115782_bb1100","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s12936-015-0946-2","article-title":"Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial","volume":"14","author":"Hawkes","year":"2015","journal-title":"Malar J"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb1105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027714","article-title":"Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria","volume":"6","author":"Serghides","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb1110","article-title":"Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial. Open Forum","volume":"2","author":"Mwanga-Amumpaire","year":"2015","journal-title":"Infect Dis"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb1115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191550","article-title":"Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial","volume":"13","author":"Bangirana","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb1120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.apjtm.2016.11.011","article-title":"The role of heme-oxygenase-1 in pathogenesis of cerebral malaria in the co-culture model of human brain microvascular endothelial cell and ITG Plasmodium falciparum-infected red blood cells","volume":"10","author":"Thongdee","year":"2017","journal-title":"Asian Pac J Trop Med"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb1125","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm1586","article-title":"Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria","volume":"13","author":"Pamplona","year":"2007","journal-title":"Nat Med"},{"issue":"37","key":"10.1016\/j.addr.2026.115782_bb1130","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1073\/pnas.0903419106","article-title":"Heme oxygenase-1 affords protection against noncerebral forms of severe malaria","volume":"106","author":"Seixas","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb1135","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1128\/AAC.05571-11","article-title":"A novel carbon monoxide-releasing molecule fully protects mice from severe malaria","volume":"56","author":"Pena","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb1140","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1128\/IAI.01404-15","article-title":"Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria","volume":"84","author":"Kayano","year":"2016","journal-title":"Infect Immun"},{"issue":"31","key":"10.1016\/j.addr.2026.115782_bb1145","doi-asserted-by":"crossref","first-page":"18999","DOI":"10.1074\/jbc.R115.642926","article-title":"CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era","volume":"290","author":"Wareham","year":"2015","journal-title":"J Biol Chem"},{"issue":"16","key":"10.1016\/j.addr.2026.115782_bb1150","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1161\/CIRCULATIONAHA.109.879338","article-title":"In vivo therapeutic gas delivery for neuroprotection with echogenic liposomes","volume":"122","author":"Britton","year":"2010","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.addr.2026.115782_bb1155","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/cns.12159","article-title":"Therapeutic time window and dose dependence of xenon delivered via echogenic liposomes for neuroprotection in stroke","volume":"19","author":"Peng","year":"2013","journal-title":"CNS Neurosci Ther"},{"issue":"8","key":"10.1016\/j.addr.2026.115782_bb1160","doi-asserted-by":"crossref","DOI":"10.3390\/biom13081256","article-title":"Enhanced Cerebroprotection of Xenon-Loaded Liposomes in Combination with rtPA Thrombolysis for Embolic Ischemic Stroke","volume":"13","author":"Peng","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.addr.2026.115782_bb1165","first-page":"155","article-title":"Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage","volume":"9","author":"Kim","year":"2014","journal-title":"Int J Nanomed."},{"key":"10.1016\/j.addr.2026.115782_bb1170","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jconrel.2015.04.027","article-title":"Therapeutic gas delivery via microbubbles and liposomes","volume":"209","author":"Fix","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.addr.2026.115782_bb1175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120798","article-title":"Modular synthesis of amphiphilic chitosan derivatives based on copper-free click reaction for drug delivery","volume":"605","author":"Tao","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.addr.2026.115782_bb1180","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H(2)S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb1185","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bcp.2015.09.014","article-title":"NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is gastrointestinal safe with all the classic therapeutic indications","volume":"98","author":"Kodela","year":"2015","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.addr.2026.115782_bb1190","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.133","article-title":"NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain","volume":"3","author":"Fonseca","year":"2015","journal-title":"Pharmacol Res Perspect"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb1195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224447","article-title":"Closed circuit xenon delivery for 72h in neonatal piglets following hypoxic insult using an ambient pressure automated control system: Development, technical evaluation and pulmonary effects","volume":"15","author":"Dingley","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.addr.2026.115782_bb1200","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1213\/ane.0b013e3181aa9550","article-title":"A closed-circuit neonatal xenon delivery system: a technical and practical neuroprotection feasibility study in newborn pigs","volume":"109","author":"Chakkarapani","year":"2009","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb1205","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1097\/00003246-199406000-00009","article-title":"Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension","volume":"22","author":"Wessel","year":"1994","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb1210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01728336","article-title":"Delivery and monitoring of inhaled nitric oxide","volume":"22","author":"Young","year":"1996","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.addr.2026.115782_bb1215","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction","volume":"83","author":"Frostell","year":"1991","journal-title":"Circulation"},{"issue":"8776","key":"10.1016\/j.addr.2026.115782_bb1220","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0140-6736(91)92033-X","article-title":"Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension","volume":"338","author":"Pepke-Zaba","year":"1991","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.addr.2026.115782_bb1225","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/STROKEAHA.107.499822","article-title":"Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia\/ischemia","volume":"39","author":"Hobbs","year":"2008","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.addr.2026.115782_bb1230","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/jama.2016.1933","article-title":"Effect of inhaled xenon on cerebral white matter damage in comatose survivors of out-of-hospital cardiac arrest: a randomized clinical trial","volume":"315","author":"Laitio","year":"2016","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.addr.2026.115782_bb1235","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/s13063-024-08231-5","article-title":"Early Hydrogen-Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial","volume":"25","author":"Lin","year":"2024","journal-title":"Trials"},{"key":"10.1016\/j.addr.2026.115782_bb1240","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101907","article-title":"Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial","volume":"58","author":"Tamura","year":"2023","journal-title":"EClinicalMed"}],"container-title":["Advanced Drug Delivery Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X26000165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169409X26000165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:36:24Z","timestamp":1782189384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169409X26000165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":248,"alternative-id":["S0169409X26000165"],"URL":"https:\/\/doi.org\/10.1016\/j.addr.2026.115782","relation":{},"ISSN":["0169-409X"],"issn-type":[{"value":"0169-409X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medicinal gases for treating central nervous system injuries","name":"articletitle","label":"Article Title"},{"value":"Advanced Drug Delivery Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.addr.2026.115782","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115782"}}