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Nanobiotechnol."},{"key":"10.1016\/j.addr.2026.115838_bb0515","doi-asserted-by":"crossref","first-page":"2411064","DOI":"10.1002\/adfm.202411064","article-title":"Defect engineering of biodegradable sulfide nanocage Sonozyme systems enables robust immunotherapy against metastatic cancers","volume":"34","author":"Cai","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.addr.2026.115838_bb0520","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1021\/acs.nanolett.4c03111","article-title":"Polysulfonium: unveiling a bioactive polymer to induce immunogenic cell death for anticancer therapy","volume":"24","author":"Lv","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2026.115838_bb0525","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41551-020-00675-9","article-title":"Prolonged activation of innate immune pathways by a polyvalent STING agonist","volume":"5","author":"Li","year":"2021","journal-title":"Nat. Biomed. 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J. Mol. Sci."},{"key":"10.1016\/j.addr.2026.115838_bb0560","doi-asserted-by":"crossref","first-page":"1103446","DOI":"10.3389\/fonc.2022.1103446","article-title":"Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours","volume":"12","author":"Ge","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.addr.2026.115838_bb0565","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2024.08.008","article-title":"Engineered bacterial membrane vesicle as safe and efficient nano-heaters to reprogram tumor microenvironment for enhanced immunotherapy","volume":"374","author":"Liu","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2026.115838_bb0570","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1021\/acschembio.4c00250","article-title":"Enhancing the anticancer activity of attenuated listeria monocytogenes by Cell Wall functionalization with \u201cclickable\u201d doxorubicin","volume":"19","author":"Lepori","year":"2024","journal-title":"ACS Chem. 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Control. Release"},{"key":"10.1016\/j.addr.2026.115838_bb0610","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1021\/acs.nanolett.4c01464","article-title":"Organic semiconducting sono-metallo-detonated immunobombs for ultrasensitized domestication of immunosuppressive cells","volume":"24","author":"Li","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.addr.2026.115838_bb0615","doi-asserted-by":"crossref","first-page":"23629","DOI":"10.1021\/acsnano.5c01678","article-title":"A metal-organic framework-based immune-regulating Nanocarrier depot for enhanced combination Cancer immunotherapy","volume":"19","author":"Wang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2026.115838_bb0620","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jconrel.2024.02.004","article-title":"Biomimetic nano-chelate diethyldithiocarbamate cu\/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy","volume":"368","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2026.115838_bb0625","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202506115","article-title":"Biomimetic manganese mineralized chemoimmunological microneedles priming cGAS-STING for robust cascade cancer therapy","volume":"21","author":"Zhang","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.addr.2026.115838_bb0630","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1038\/s41467-025-64023-8","article-title":"Micro-nano microbial fuel cell-driven bioelectrochemical tumor therapy","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.addr.2026.115838_bb0635","doi-asserted-by":"crossref","first-page":"1156239","DOI":"10.3389\/fimmu.2023.1156239","article-title":"Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.addr.2026.115838_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112951","article-title":"Manganese-mediated potentiation of antitumor immune responses by enhancing KLRG1+ macrophage function","volume":"141","author":"Ge","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.addr.2026.115838_bb0645","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1021\/acsnano.3c12745","article-title":"Tumor microenvironment-activatable nanosystem capable of overcoming multiple therapeutic obstacles for augmenting immuno\/metal-ion therapy","volume":"18","author":"Cheng","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2026.115838_bb0650","doi-asserted-by":"crossref","first-page":"21855","DOI":"10.1021\/acsnano.3c12375","article-title":"Enzyme-dynamic extracellular vesicles for Metalloimmunotherapy of malignant pleural effusions","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2026.115838_bb0655","article-title":"Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy","volume":"27","author":"Li","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.addr.2026.115838_bb0660","doi-asserted-by":"crossref","first-page":"30701","DOI":"10.1021\/acsnano.4c09902","article-title":"Spleen-targeted mRNA vaccine doped with manganese adjuvant for robust anticancer immunity in vivo","volume":"18","author":"Luo","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2026.115838_bb0665","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-065X.2007.00561.x","article-title":"Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity","volume":"220","author":"Fujii","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.addr.2026.115838_bb0670","doi-asserted-by":"crossref","first-page":"11126","DOI":"10.1039\/D4NR00847B","article-title":"A natural killer T cell nanoagonist-initiated immune cascade for hepatocellular carcinoma synergistic immunotherapy","volume":"16","author":"Luo","year":"2024","journal-title":"Nanoscale"},{"key":"10.1016\/j.addr.2026.115838_bb0675","doi-asserted-by":"crossref","first-page":"217908","DOI":"10.1016\/j.canlet.2025.217908","article-title":"The calcium homeostasis in tumor and the mechanism involving progression and metastasis","volume":"630","author":"Qin","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.addr.2026.115838_bb0680","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1021\/acsnano.4c00550","article-title":"Modulation of dendritic cell function via nanoparticle-induced cytosolic calcium changes","volume":"18","author":"Cao","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.addr.2026.115838_bb0685","doi-asserted-by":"crossref","first-page":"11986","DOI":"10.1021\/acsanm.5c01535","article-title":"In vitro evaluation of flame-made calcium phosphate nanoparticles for antigen delivery and Immunostimulation","volume":"8","author":"Maheshwari","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.addr.2026.115838_bb0690","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jconrel.2023.01.043","article-title":"Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy","volume":"354","author":"Jia","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.addr.2026.115838_bb0695","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.addr.2026.115838_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103755","article-title":"Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies","volume":"85","author":"Cui","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.addr.2026.115838_bb0705","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12951-023-01825-2","article-title":"Theranostic applications of selenium nanomedicines against lung cancer","volume":"21","author":"Liu","year":"2023","journal-title":"J. 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