{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:52:45Z","timestamp":1761623565534,"version":"build-2065373602"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":3168,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Actas Dermo-Sifiliogr\u00e1ficas (English Edition)"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.adengl.2011.04.006","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T07:27:29Z","timestamp":1333006049000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic and Histologic Characteristics of Cutaneous Melanoma in Patients With Melanocortin-1 Receptor Polymorphisms"],"prefix":"10.1016","volume":"103","author":[{"given":"J.A.","family":"Avil\u00e9s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"L\u00e1zaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ibarrola-Villava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adengl.2011.04.006_bib0005","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0001-7310(05)73105-7","article-title":"Epidemiolog\u00eda del melanoma en Espa\u00f1a","volume":"96","author":"S\u00e1enz","year":"2005","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.adengl.2011.04.006_bib0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00008390-199311000-00002","article-title":"How much melanoma is caused by sun exposure?","volume":"3","author":"Armstrong","year":"1993","journal-title":"Melanoma Res"},{"key":"10.1016\/j.adengl.2011.04.006_bib0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0001-7310(06)73390-7","article-title":"Predisposici\u00f3n gen\u00e9tica en el melanoma cut\u00e1neo","volume":"97","author":"Avil\u00e9s","year":"2006","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.adengl.2011.04.006_bib0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-1119(01)00694-1","article-title":"Human pigmentation genes: identification, structure and consequences of polymorphic variation","volume":"277","author":"Sturm","year":"2001","journal-title":"Gene"},{"key":"10.1016\/j.adengl.2011.04.006_bib0025","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.peptides.2004.11.021","article-title":"The relation between melanocortin 1 receptor (MC1R) variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation","volume":"26","author":"Wong","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.adengl.2011.04.006_bib0030","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/ijc.22074","article-title":"Melanocortin 1 receptor variants and skin cancer risk","volume":"119","author":"Han","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.adengl.2011.04.006_bib0035","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/hmg\/ddi219","article-title":"Altered cell surface expression of human MC1R variant receptor alleles associated with red hair and skin cancer risk","volume":"14","author":"Beaumont","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.adengl.2011.04.006_bib0040","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.0022-202X.2004.23444.x","article-title":"Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair","volume":"123","author":"Ringholm","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0045","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.peptides.2004.11.031","article-title":"Activation of the cAMP pathway by variant human MC1R alleles expressed in HEK and melanoma cells","volume":"26","author":"Newton","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.adengl.2011.04.006_bib0050","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1002\/cncr.24994","article-title":"Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?","volume":"116","author":"Kanetsky","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.adengl.2011.04.006_bib0055","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1086\/319500","article-title":"Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair","volume":"68","author":"Bastiaens","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.adengl.2011.04.006_bib0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1523-1747.1998.00252.x","article-title":"Melanocortin 1 receptor variants in an Irish population","volume":"111","author":"Smith","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0065","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ng1195-328","article-title":"Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans","volume":"11","author":"Valverde","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.adengl.2011.04.006_bib0070","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1136\/jmg.2003.011536","article-title":"Melanocortin 1 receptor (MC1R) gene variants may increase the risk of melanoma in France independently of clinical risk factors and UV exposure","volume":"41","author":"Matichard","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.adengl.2011.04.006_bib0075","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1038\/sj.jid.5700292","article-title":"Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk Southern European population","volume":"126","author":"Stratigos","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0080","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1755-148X.2008.00526.x","article-title":"MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters","volume":"22","author":"H\u00f6iom","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.adengl.2011.04.006_bib0085","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/CMR.0b013e32833b159d","article-title":"Influence of loss of function MC1R variants in genetic susceptibility of familial melanoma in Spain","volume":"20","author":"de Torre","year":"2010","journal-title":"Melanoma Res"},{"key":"10.1016\/j.adengl.2011.04.006_bib0090","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/carcin\/bgm084","article-title":"MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population","volume":"28","author":"Fernandez","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.adengl.2011.04.006_bib0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0001-7310(09)70536-8","article-title":"Perfil cl\u00ednico y epidemiol\u00f3gico de los pacientes con melanoma cut\u00e1neo seg\u00fan el grado de exposici\u00f3n solar de la localizaci\u00f3n del melanoma","volume":"100","author":"Nagore","year":"2009","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.adengl.2011.04.006_bib0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ad.2009.07.005","article-title":"Pero\u2026\u00bfhubo alguna vez una clasificaci\u00f3n de Clark de los melanomas?","volume":"101","author":"S\u00e1nchez Yus","year":"2010","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.adengl.2011.04.006_bib0105","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/archderm.144.10.1375","article-title":"Three roots of melanoma","volume":"144","author":"Zalaudek","year":"2008","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0110","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1001\/archderm.142.12.1551","article-title":"Rate of growth in melanomas","volume":"142","author":"Liu","year":"2006","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-148X.2009.00647.x","article-title":"Dormancy of metastatic melanoma","volume":"23","author":"Ossowski","year":"2010","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.adengl.2011.04.006_bib0120","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/humu.9150","article-title":"Identification of four novel melanocortin 1 receptor (MC1R) gene variants in a Mediterranean population","volume":"21","author":"Fargnoli","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.adengl.2011.04.006_bib0125","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1600-0625.2009.00846.x","article-title":"Pigmentation-related genes and their implication in malignant melanoma susceptibility","volume":"18","author":"Fernandez","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.adengl.2011.04.006_bib0130","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/ijc.24548","article-title":"Melanocortin receptor 1 variants and melanoma risk: a study of 2 European populations","volume":"125","author":"Scherer","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.adengl.2011.04.006_bib0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1157\/13090479","article-title":"Epidemiolog\u00eda y supervivencia del melanoma cut\u00e1neo en Espa\u00f1a: estudio de 552 casos (1994\u20132003)","volume":"206","author":"Avil\u00e9s","year":"2006","journal-title":"Rev Clin Esp"}],"container-title":["Actas Dermo-Sifiliogr\u00e1ficas (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1578219012000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1578219012000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:48:11Z","timestamp":1761623291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1578219012000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1578219012000455"],"URL":"https:\/\/doi.org\/10.1016\/j.adengl.2011.04.006","relation":{},"ISSN":["1578-2190"],"issn-type":[{"type":"print","value":"1578-2190"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic and Histologic Characteristics of Cutaneous Melanoma in Patients With Melanocortin-1 Receptor Polymorphisms","name":"articletitle","label":"Article Title"},{"value":"Actas Dermo-Sifiliogr\u00e1ficas (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adengl.2011.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ad.2011.04.009","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Espa\u00f1a, S.L. and AEDV.","name":"copyright","label":"Copyright"}]}}