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The current study explores ways in which maternal depression, family factors, and adolescent sex interact. Data were from a cross\u2010sectional study of 176 mother\u2013daughter dyads, including a subset of mothers with HIV. Logistic regression analyses revealed that among mothers who were not current marijuana users, more maternal depressive symptoms was associated with daughters' engagement in sexual intercourse. Neither parent\u2010child conflict nor parental involvement significantly mediated the relationship between maternal depressive symptoms and adolescent sex. 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