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This study tested whether sleep duration and dysregulation of sleep\u2010wake patterns in late\u2010elementary school youth were prospectively associated with cigarette and alcohol use initiation and how sleep\u2010related changes in inhibitory control mediate these relationships. Average sleep duration at 4th grade predicted 6th grade cigarette but not alcohol use, however indirect effects were identified through 5th grade inhibitory control to both cigarette and alcohol use. Indirect effects were also identified through inhibitory control for relationships between 4th grade weekend bed\u2010time delay and 6th grade cigarette or alcohol use, and for relationships between 4th grade weekend wake\u2010time delay and 6th grade cigarette or alcohol use. Reductions in nightly sleep increased risk of cigarette use. 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