{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:06:34Z","timestamp":1785557194395,"version":"3.56.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescence"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Puberty is a physiological event involving the attainment of reproductive capability and complete development of sexual and physical organs. Changing from childhood to adulthood is a complex process and is tightly controlled by interconnection pathways at the level of the hypothalamus which can be influenced by environmental, psychosocial, and endocrine factors. Although various mechanisms underlying the onset of normal puberty have been investigated in humans and animals, the exact molecular mechanisms thereof remain unclear. The aim of this review is to summarize the current state of knowledge and provide a synoptic overview about the physiology of puberty in adolescent boys and girls, and describe pathological disorders affecting its onset.<\/jats:p>","DOI":"10.1016\/j.adolescence.2018.12.007","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T14:20:40Z","timestamp":1547475640000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Physiology of puberty in boys and girls and pathological disorders affecting its onset"],"prefix":"10.1002","volume":"71","author":[{"given":"Mohammed F.","family":"Alotaibi","sequence":"first","affiliation":[{"name":"Department of Physiology College of Medicine King Saud University and King Khalid University Hospital P.O Box 2925 Riyadh 11461 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.131"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119172"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2009.01930.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510747"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.4.940"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053168"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70265-2"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2010.04.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900136"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2007.00145.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0541"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2013.18.4.183"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.815"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2013.00176.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199003000-00003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1375\/1369052042335278"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090099697"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8624.00159"},{"issue":"11","key":"e_1_2_12_20_1","first-page":"625","article-title":"Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age","volume":"51","author":"Elmlinger M.W.","year":"2005","journal-title":"Clinical Laboratory"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800485"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32505"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.01.038"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.38.1.42"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1305"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000120022.14101.11"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.98.2.201"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90423-Y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-3-458"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.03.006"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.347"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20626"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200008000-00020"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2188"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.258"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","unstructured":"J.M.Lee R.Wasserman N.Kaciroti A.Gebremariam J.Steffes S.Dowshen et al.Timing of puberty in overweight versus obese boys.Pediatrics2016 peds.2015\u20130164","DOI":"10.1542\/peds.2015-0164"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0022"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0136"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409330102"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272431698018001002"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.1.29"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.3.1074"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.12.002"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1569-09.2009"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v3i1.01"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3902"},{"issue":"6","key":"e_1_2_12_49_1","first-page":"240","article-title":"Testicular size: Assessment and clinical importance. Triangle","volume":"7","author":"Prader A.","year":"1966","journal-title":"The Sandoz Journal of Medical Science"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-27"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1100"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1693"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200208000-00003"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5740-08.2009"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372205"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803156"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118891"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8395"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu009"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2006.01417.x"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0488"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0323"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704114104"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.306"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111184"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.03.011"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.20106"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2001.0186"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.5.903"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1763"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2013.09.006"},{"issue":"1","key":"e_1_2_12_73_1","first-page":"61","article-title":"Testicular volume during adolescence: Cross sectional and longitudinal studies","volume":"29","author":"Zachmann M.","year":"1974","journal-title":"Helvetica Paediatrica Acta"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.06.005"}],"container-title":["Journal of Adolescence"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140197118302239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0140197118302239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.adolescence.2018.12.007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.adolescence.2018.12.007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.adolescence.2018.12.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T10:43:58Z","timestamp":1693133038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.adolescence.2018.12.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1016\/j.adolescence.2018.12.007"],"URL":"https:\/\/doi.org\/10.1016\/j.adolescence.2018.12.007","archive":["Portico"],"relation":{},"ISSN":["0140-1971","1095-9254"],"issn-type":[{"value":"0140-1971","type":"print"},{"value":"1095-9254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,14]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiology of puberty in boys and girls and pathological disorders affecting its onset","name":"articletitle","label":"Article Title"},{"value":"Journal of Adolescence","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adolescence.2018.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}