{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:21:12Z","timestamp":1782933672900,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T00:00:00Z","timestamp":1488499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.adro.2017.03.001","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T01:25:36Z","timestamp":1489109136000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effects of vertebral-body-sparing proton craniospinal irradiation on the spine of young pediatric patients with medulloblastoma"],"prefix":"10.1016","volume":"2","author":[{"given":"Iain","family":"MacEwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Moretz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Loredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry D.","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2017.03.001_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s003810100496","article-title":"Epidemiology of central nervous system tumors in childhood and adolescence based on the new who classification","volume":"17","author":"Rickert","year":"2001","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.adro.2017.03.001_bib2","series-title":"Pediatric Radiation Oncology","first-page":"53","article-title":"Tumors of the posterior fossa and the spinal canal","author":"Halperin","year":"2011"},{"key":"10.1016\/j.adro.2017.03.001_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/neuonc\/nos267","article-title":"Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: Results of Children's Oncology Group trial a9961","volume":"15","author":"Packer","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ijrobp.2013.05.037","article-title":"Pediatric CSI: Are protons the only ethical approach?","volume":"87","author":"Johnstone","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijrobp.2013.05.036","article-title":"Protons for craniospinal radiation: Are clinical data important?","volume":"87","author":"Wolden","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1088\/0031-9155\/38\/10\/001","article-title":"Current developments in proton therapy: A review","volume":"38","author":"Bonnett","year":"1993","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.adro.2017.03.001_bib7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/sj.bjc.6602754","article-title":"Proton beam therapy","volume":"93","author":"Levin","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.adro.2017.03.001_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.radonc.2007.03.001","article-title":"Proton therapy - a systematic review of clinical effectiveness","volume":"83","author":"Olsen","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.semradonc.2006.04.008","article-title":"Radiation therapy with charged particles","volume":"16","author":"Schulz-Ertner","year":"2006","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2006.09.7816","article-title":"Particle radiation therapy using proton and heavier ion beams","volume":"25","author":"Schulz-Ertner","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1748-717X-7-116","article-title":"Comparison of therapeutic dosimetric data from passively scattered proton and photon craniospinal irradiations for medulloblastoma","volume":"7","author":"Howell","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib12","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ijrobp.2007.02.021","article-title":"Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation","volume":"68","author":"Krejcarek","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/02841860500218819","article-title":"Does electron and proton therapy reduce the risk of radiation induced cancer after spinal irradiation for childhood medulloblastoma? A comparative treatment planning study","volume":"44","author":"Mu","year":"2005","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/153303460600500202","article-title":"Clinical applications of proton radiation treatment at Loma Linda University: Review of a fifteen-year experience","volume":"5","author":"Slater","year":"2006","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.adro.2017.03.001_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0360-3016(92)90058-P","article-title":"The proton treatment center at Loma Linda University Medical Center: Rationale for and description of its development","volume":"22","author":"Slater","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0360-3016(03)01574-8","article-title":"Advantage of protons compared to conventional x-ray or imrt in the treatment of a pediatric patient with medulloblastoma","volume":"58","author":"St Clair","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ncponc0090","article-title":"Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors","volume":"1","author":"Yock","year":"2004","journal-title":"Nat Clin Pract Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijrobp.2013.01.014","article-title":"Proton beam craniospinal irradiation reduces acute toxicity for adults with medulloblastoma","volume":"86","author":"Brown","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib19","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0360-3016(01)02717-1","article-title":"Acute toxicity and treatment interruption related to electron and photon craniospinal irradiation in pediatric patients treated at the University of Texas MD Anderson Cancer Center","volume":"52","author":"Chang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib20","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/1097-0142(197903)43:3<1014::AID-CNCR2820430334>3.0.CO;2-9","article-title":"Medulloblastoma: Treatment results and effect on normal tissues","volume":"43","author":"Cumberlin","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2017.03.001_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mpo.2950250110","article-title":"Hematologic toxicity during craniospinal irradiation: The impact of prior chemotherapy","volume":"25","author":"Marks","year":"1995","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<348::AID-MPO4>3.0.CO;2-H","article-title":"Survival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old","volume":"28","author":"Kiltie","year":"1997","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib23","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1200\/JCO.2006.06.4980","article-title":"Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma","volume":"24","author":"Packer","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib24","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1210\/jc.2003-030619","article-title":"Adult height and adult sitting height in childhood medulloblastoma survivors","volume":"88","author":"Xu","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.adro.2017.03.001_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2106\/00004623-195032020-00019","article-title":"Radiation-induced scoliosis; a case report","volume":"32A","author":"Arkin","year":"1950","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.adro.2017.03.001_bib26","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2106\/00004623-195032020-00018","article-title":"Radiation scoliosis; an experimental study","volume":"32A","author":"Arkin","year":"1950","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.adro.2017.03.001_bib27","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.2214\/AJR.07.7145","article-title":"Radiographic evaluation of scoliosis: Review","volume":"194","author":"Malfair","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.adro.2017.03.001_bib28","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/59.5.637","article-title":"Irradiation effects of roentgen therapy on the growing spine","volume":"59","author":"Neuhauser","year":"1952","journal-title":"Radiology"},{"key":"10.1016\/j.adro.2017.03.001_bib29","first-page":"S209","article-title":"Scoliosis in children receiving craniospinal irradiation for medulloblastoma","volume":"62","author":"Paulino","year":"2015","journal-title":"Pediatric Blood & Cancer"},{"key":"10.1016\/j.adro.2017.03.001_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01956143","article-title":"Spinal deformity induced by radiotherapy for solid tumours in childhood: A long-term follow up study","volume":"152","author":"Makipernaa","year":"1993","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.adro.2017.03.001_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2106\/00004623-198163020-00002","article-title":"Spinal deformity in children treated for neuroblastoma","volume":"63","author":"Mayfield","year":"1981","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.adro.2017.03.001_bib32","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0360-3016(99)00534-9","article-title":"Late effects in children treated with radiation therapy for Wilms' tumor","volume":"46","author":"Paulino","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.03.001_bib33","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.mri.2014.03.005","article-title":"Proton density water fraction as a biomarker of bone marrow cellularity: Validation in ex\u00a0vivo spine specimens","volume":"32","author":"MacEwan","year":"2014","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.adro.2017.03.001_bib34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/00130404-200411000-00009","article-title":"Reducing toxicity from craniospinal irradiation: Using proton beams to treat medulloblastoma in young children","volume":"10","author":"Yuh","year":"2004","journal-title":"Cancer J"},{"key":"10.1016\/j.adro.2017.03.001_bib35","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1470-2045(15)00167-9","article-title":"Long-term toxic effects of proton radiotherapy for paediatric medulloblastoma: A phase 2 single-arm study","volume":"17","author":"Yock","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2017.03.001_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijrobp.2015.09.014","article-title":"Clinical outcomes among children with standard-risk medulloblastoma treated with proton and photon radiation therapy: A comparison of disease control and overall survival","volume":"94","author":"Eaton","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109417300416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109417300416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:34:48Z","timestamp":1762529688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109417300416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S2452109417300416"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2017.03.001","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of vertebral-body-sparing proton craniospinal irradiation on the spine of young pediatric patients with medulloblastoma","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2017.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 the Authors. Published by Elsevier Inc. on behalf of the American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}