{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:44:30Z","timestamp":1787841870772,"version":"build-2784847793"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.adro.2017.05.008","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T17:27:11Z","timestamp":1497115631000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity"],"prefix":"10.1016","volume":"2","author":[{"given":"Rachel B.","family":"Jimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Mahadevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Niemierko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvan","family":"Rajakesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils D.","family":"Arvold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A.","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2017.05.008_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11060-004-8093-6","article-title":"Brain metastases: Epidemiology and pathophysiology","volume":"75","author":"Gavrilovic","year":"2005","journal-title":"J Neurooncol"},{"key":"10.1016\/j.adro.2017.05.008_bib2","series-title":"Cancer: Principles and Practice of Oncology","first-page":"1700","article-title":"Neoplasms of the central nervous system","author":"Mehta","year":"2011"},{"key":"10.1016\/j.adro.2017.05.008_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0360-3016(80)90195-9","article-title":"The palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group","volume":"6","author":"Borgelt","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib4","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1001\/jama.280.17.1485","article-title":"Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial","volume":"280","author":"Patchell","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2017.05.008_bib5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","article-title":"Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952-26001 study","volume":"29","author":"Kocher","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib6","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1001\/jama.295.21.2483","article-title":"Stereotactic radiosurgery plus whole-brain radiation therapy versus stereotactic radiosurgery alone for treatment of brain metastases: A randomized controlled trial","volume":"295","author":"Aoyama","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2017.05.008_bib7","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1200\/JCO.2006.09.2536","article-title":"Regression after whole-brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function","volume":"25","author":"Li","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib8","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1200\/JCO.1994.12.3.627","article-title":"Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy","volume":"12","author":"Crossen","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa035091","article-title":"Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia","volume":"349","author":"Pui","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2017.05.008_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1200\/JCO.2010.29.6053","article-title":"Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: Neurocognitive and quality-of-life analysis","volume":"29","author":"Sun","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib11","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0360-3016(95)02106-X","article-title":"Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: Initial report of radiation therapy oncology group protocol (90-05)","volume":"34","author":"Shaw","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib12","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0140-6736(04)16250-8","article-title":"Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial","volume":"363","author":"Andrews","year":"2004","journal-title":"Lancet"},{"issue":"3 Suppl","key":"10.1016\/j.adro.2017.05.008_bib13","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ijrobp.2009.08.078","article-title":"Radiation associated brainstem injury","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1 Suppl","key":"10.1016\/j.adro.2017.05.008_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000098784","article-title":"Radiation sensitivity of visual and oculomotor pathways","volume":"64","author":"Leber","year":"1995","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.adro.2017.05.008_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0360-3016(03)00014-2","article-title":"Hypofractionated stereotactic radiotherapy alone without whole brain irradiation for patients with solitary and oligo brain metastasis using noninvasive fixation of the skull","volume":"56","author":"Aoyama","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib16","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/cncr.24082","article-title":"Hypofractionated stereotactic radiotherapy for the treatment of brain metastases","volume":"115","author":"Kwon","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2017.05.008_bib17","doi-asserted-by":"crossref","first-page":"e0163304","DOI":"10.1371\/journal.pone.0163304","article-title":"Fractionated stereotactic gamma knife radiosurgery for large brain metastases: A retrospective, single center study","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.adro.2017.05.008_bib18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13014-016-0653-3","article-title":"Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection","volume":"11","author":"Navarria","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11060-014-1388-3","article-title":"Fractionated stereotactic radiosurgery for patients with brain metastases","volume":"117","author":"Minniti","year":"2014","journal-title":"J Neurooncol"},{"key":"10.1016\/j.adro.2017.05.008_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2006.08.024","article-title":"Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: Results and toxicity","volume":"81","author":"Ernst-Stecken","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib21","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1200\/JCO.1990.8.7.1277","article-title":"Response criteria for phase II studies of supratentorial malignant glioma","volume":"8","author":"Macdonald","year":"1990","journal-title":"J Cli Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib22","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.ijrobp.2011.05.034","article-title":"Compatibility of the linear-quadratic formalism and biologically effective dose concept to high-dose-per-fraction irradiation in a murine tumor","volume":"81","author":"Otsuka","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/jrr\/rrt138","article-title":"Applicability of the linear-quadratic model to single and fractionated radiotherapy schedules: An experimental study","volume":"55","author":"Miyakawa","year":"2013","journal-title":"J Radiat Res"},{"key":"10.1016\/j.adro.2017.05.008_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2013.08.027","article-title":"Use of the LQ model with large fraction sizes results in underestimation of isoeffect doses","volume":"109","author":"Sheu","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib25","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3109\/0284186X.2012.728292","article-title":"The impact of fractionation in SBRT: Analysis with the linear quadratic model and the universal survival curve model","volume":"52","author":"Wennberg","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2007.10.059","article-title":"Universal survival curve and single fraction equivalent dose: Useful tools in understanding potency of ablative radiotherapy","volume":"70","author":"Park","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7785\/tcrt.2012.500306","article-title":"A comparative analysis of radiobiological models for cell surviving fractions at high doses","volume":"12","author":"Andisheh","year":"2013","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.adro.2017.05.008_bib28","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/ijo.2013.1857","article-title":"Cell survival and radiosensitization: Modulation of the linear and quadratic parameters of the LQ model (review)","volume":"42","author":"Franken","year":"2013","journal-title":"Int J Oncol"},{"key":"10.1016\/j.adro.2017.05.008_bib29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijrobp.2013.07.022","article-title":"The tumor radiobiology of SRS and SBRT: Are more than the 5 Rs involved?","volume":"88","author":"Brown","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2017.05.008_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11060-007-9458-4","article-title":"Gamma knife radiosurgery for brainstem metastases: The UCSF experience","volume":"86","author":"Kased","year":"2008","journal-title":"J Neurooncol"},{"key":"10.1016\/j.adro.2017.05.008_bib31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s11060-010-0514-0","article-title":"Linear accelerator-based stereotactic radiosurgeryfor brainstem metastases: The Dana-Farber\/Brigham and Women\u2019s Cancer Center experience","volume":"104","author":"Kelly","year":"2011","journal-title":"J Neurooncol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109417300982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109417300982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:35:16Z","timestamp":1762529716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109417300982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S2452109417300982"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2017.05.008","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2017.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 the Authors. Published by Elsevier Inc. on behalf of the American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}