{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:10:50Z","timestamp":1790701850056,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.adro.2019.01.005","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T07:30:13Z","timestamp":1548574213000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer"],"prefix":"10.1016","volume":"4","author":[{"given":"Michael D.","family":"Schad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil W.","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishni","family":"Wijesooriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.","family":"Showalter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2019.01.005_bib1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13014-015-0540-3","article-title":"Favorable outcomes in locally advanced and node positive prostate cancer patients treated with combined pelvic imrt and androgen deprivation therapy","volume":"10","author":"Lilleby","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2019.01.005_bib2","series-title":"Androgen deprivation therapy and high dose radiotherapy with or without whole-pelvic radiotherapy in unfavorable intermediate or favorable high risk prostate cancer: A phase III randomized trial (RTOG 0924)","year":"2009"},{"key":"10.1016\/j.adro.2019.01.005_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.critrevonc.2018.01.003","article-title":"A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors","volume":"123","author":"Venkatesulu","year":"2018","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.adro.2019.01.005_bib4","first-page":"3541","article-title":"Prognostic value of severe lymphopenia during pelvic concurrent chemoradiotherapy in cervical cancer","volume":"36","author":"Cho","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1016\/j.adro.2019.01.005_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317734303","article-title":"Prognostic implication of simultaneous anemia and lymphopenia during concurrent chemoradiotherapy in cervical squamous cell carcinoma","volume":"39","author":"Cho","year":"2017","journal-title":"Tumour Biol"},{"key":"10.1016\/j.adro.2019.01.005_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/COC.0b013e3182940ff9","article-title":"The association between chemoradiation-related lymphopenia and clinical outcomes in patients with locally advanced pancreatic adenocarcinoma","volume":"38","author":"Wild","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.adro.2019.01.005_bib7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijrobp.2015.11.026","article-title":"Lymphocyte-sparing effect of stereotactic body radiation therapy in patients with unresectable pancreatic cancer","volume":"94","author":"Wild","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2019.01.005_bib8","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1158\/1078-0432.CCR-17-1323","article-title":"Higher absolute lymphocyte counts predict lower mortality from early-stage triple-negative breast cancer","volume":"24","author":"Afghahi","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.adro.2019.01.005_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4143\/crt.2016.595","article-title":"The prognostic value of treatment-related lymphopenia in nasopharyngeal carcinoma patients","volume":"50","author":"Liu","year":"2018","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.adro.2019.01.005_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/07357907.2013.767342","article-title":"Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer","volume":"31","author":"Campian","year":"2013","journal-title":"Cancer Invest"},{"key":"10.1016\/j.adro.2019.01.005_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ijrobp.2014.04.025","article-title":"Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes","volume":"89","author":"Tang","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2019.01.005_bib12","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.6004\/jnccn.2015.0151","article-title":"Survival in patients with severe lymphopenia following treatment with radiation and chemotherapy for newly diagnosed solid tumors","volume":"13","author":"Grossman","year":"2015","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.adro.2019.01.005_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.radonc.2017.11.028","article-title":"Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy","volume":"128","author":"Shiraishi","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2019.01.005_bib14","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.ijrobp.2015.04.005","article-title":"Clinical and dosimetric predictors of acute severe lymphopenia during radiation therapy and concurrent temozolomide for high-grade glioma","volume":"92","author":"Huang","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2019.01.005_bib15","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1515\/raon-2016-0050","article-title":"Dosimetric predictors of treatment-related lymphopenia induced by palliative radiotherapy: Predictive ability of dose-volume parameters based on body surface contour","volume":"51","author":"Saito","year":"2016","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.adro.2019.01.005_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ijrobp.2017.02.029","article-title":"In reply to Yazici et\u00a0al","volume":"98","author":"Chadha","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2019.01.005_bib17","first-page":"359","article-title":"Changes in natural killer cell activity by external radiotherapy and\/or brachytherapy","volume":"9","author":"Yamazaki","year":"2002","journal-title":"Oncol Rep"},{"key":"10.1016\/j.adro.2019.01.005_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/07357907.2012.762780","article-title":"The etiology of treatment-related lymphopenia in patients with malignant gliomas: Modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells","volume":"31","author":"Yovino","year":"2013","journal-title":"Cancer Invest"},{"key":"10.1016\/j.adro.2019.01.005_bib19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2307\/3577549","article-title":"Radiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in\u00a0vitro colony formation assay","volume":"123","author":"Nakamura","year":"1990","journal-title":"Radiat Res"},{"key":"10.1016\/j.adro.2019.01.005_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijrobp.2018.01.069","article-title":"Effect of radiation treatment volume reduction on lymphopenia in patients receiving chemoradiotherapy for glioblastoma","volume":"101","author":"Rudra","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2019.01.005_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1001\/archsurg.1970.01340260018003","article-title":"Radiation-induced lymphocyte-immune deficiency: A factor in the increased visceral metastases and decreased hormonal responsiveness of breast cancer","volume":"101","author":"Meyer","year":"1970","journal-title":"Arch Surg"},{"key":"10.1016\/j.adro.2019.01.005_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1567-5769(03)00013-4","article-title":"Long-term immune dysfunction after radiotherapy to the head and neck area","volume":"3","author":"Verastegui","year":"2003","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.adro.2019.01.005_bib23","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI108532","article-title":"Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease","volume":"58","author":"Fuks","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.adro.2019.01.005_bib24","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/0959-8049(92)90079-H","article-title":"Changes of lymphocyte subsets after local irradiation for early stage breast cancer and seminoma testis: Long-term increase of activated (HLA-DR+) T cells and decrease of \u201cnaive\u201d (CD4-CD45R) T lymphocytes","volume":"28A","author":"De Ruysscher","year":"1992","journal-title":"Eur J Cancer"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109419300065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109419300065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:36:47Z","timestamp":1762529807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109419300065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S2452109419300065"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2019.01.005","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2019.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}]}}