{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:15:37Z","timestamp":1780107337576,"version":"3.54.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.adro.2022.101034","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T13:14:29Z","timestamp":1666790069000},"page":"101034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Online Adaptive Radiation Therapy and Opportunity Cost"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-2485","authenticated-orcid":false,"given":"Kyra N.","family":"McComas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Yock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleb","family":"Darrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2022.101034_bib0001","series-title":"Grainger & Allison's Diagnostic Radiology","article-title":"Imaging for radiotherapy planning: Adaptive radiotherapy","author":"Hoskin","year":"2021"},{"key":"10.1016\/j.adro.2022.101034_bib0002","doi-asserted-by":"crossref","DOI":"10.1088\/0031-9155\/42\/1\/008","article-title":"Adaptive radiation therapy","volume":"42","author":"Yan","year":"1997","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.adro.2022.101034_bib0003","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ijrobp.2020.10.021","article-title":"Adaptive radiation therapy (ART) strategies and technical considerations: A state of the ART review from NRG Oncology","volume":"109","author":"Glide-Hurst","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0004","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1118\/1.3215532","article-title":"An on-line replanning method for head and neck adaptive radiotherapy","volume":"36","author":"Ahunbay","year":"2009","journal-title":"Med Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0005","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.radonc.2017.11.032","article-title":"Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of the abdomen","volume":"126","author":"Henke","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2022.101034_bib0006","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/j.prro.2018.08.010","article-title":"Dosimetric benefits and practical pitfalls of daily online adaptive MRI-guided stereotactic radiation therapy for pancreatic cancer","volume":"9","author":"El-Bared","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2022.101034_bib0007","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.radonc.2011.08.027","article-title":"Development of an online adaptive solution to account for inter- and intra-fractional variations","volume":"100","author":"Li","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2022.101034_bib0008","doi-asserted-by":"crossref","first-page":"e423","DOI":"10.1016\/j.ijrobp.2011.12.073","article-title":"Characterization and management of interfractional anatomic changes for pancreatic cancer radiotherapy","volume":"83","author":"Liu","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0009","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejmp.2020.07.027","article-title":"Assessment of online adaptive MR-guided stereotactic body radiotherapy of liver cancers","volume":"77","author":"Padgett","year":"2020","journal-title":"Physica Medica"},{"key":"10.1016\/j.adro.2022.101034_bib0010","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2004.09.045","article-title":"An automatic CT-guided adaptive radiation therapy technique by online modification of multileaf collimator leaf positions for prostate cancer","volume":"62","author":"Court","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0011","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.ijrobp.2009.10.013","article-title":"Online adaptive replanning method for prostate radiotherapy","volume":"77","author":"Ahunbay","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0012","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.ijrobp.2004.11.033","article-title":"Use of deformed intensity distributions for on-line modification of image-guided IMRT to account for interfractional anatomic changes","volume":"61","author":"Mohan","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0013","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ijrobp.2014.06.046","article-title":"Clinical implementation of an online adaptive plan-of-the-day protocol for nonrigid motion management in locally advanced cervical cancer IMRT","volume":"90","author":"Heijkoop","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0014","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/acm2.13425","article-title":"Initial analysis of the dosimetric benefit and clinical resource cost of CBCT-based online adaptive radiotherapy for patients with cancers of the cervix or rectum","volume":"22","author":"Yock","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0015","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.canrad.2020.10.002","article-title":"Plan of the day adaptive radiotherapy for bladder cancer: Dosimetric and clinical results","volume":"25","author":"Cabaill\u00e9","year":"2021","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.adro.2022.101034_bib0016","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.adro.2018.10.003","article-title":"Stereotactic MR-Guided Online Adaptive Radiation Therapy (SMART) for ultracentral thorax malignancies: Results of a phase 1 trial","volume":"4","author":"Henke","year":"2018","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2022.101034_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.564857","article-title":"Cone-beam-CT guided adaptive radiotherapy for locally advanced non-small cell lung cancer enables quality assurance and superior sparing of healthy lung","volume":"10","author":"Hoegen","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2022.101034_bib0018","article-title":"Making on-line adaptive radiotherapy possible using artificial intelligence and machine learning for efficient daily re-planning","volume":"8","author":"Archambault","year":"2020","journal-title":"Med Phys Int J"},{"key":"10.1016\/j.adro.2022.101034_bib0019","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1016\/j.ijrobp.2020.07.658","article-title":"Adaptive radiotherapy can be applied routinely, using an artificial intelligence solution, to treat prostate cancer patients","volume":"108","author":"van Dieren","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0020","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.ijrobp.2009.04.047","article-title":"Adaptive replanning strategies accounting for shrinkage in head and neck IMRT","volume":"75","author":"Wu","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2022.101034_bib0021","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/02841860600936369","article-title":"Individualized image guided iso-NTCP based liver cancer SBRT","volume":"45","author":"Dawson","year":"2006","journal-title":"Acta Oncologica"},{"key":"10.1016\/j.adro.2022.101034_bib0022","doi-asserted-by":"crossref","first-page":"e974","DOI":"10.1200\/OP.21.00644","article-title":"Estimating the practice-level and national cost burden of treatment-related prior authorization for academic radiation oncology practices","volume":"18","author":"Bingham","year":"2022","journal-title":"JCO Oncol Pract"},{"key":"10.1016\/j.adro.2022.101034_bib0023","first-page":"131","article-title":"Time-driven activity-based costing","volume":"82","author":"Kaplan","year":"2004","journal-title":"Harv Bus Rev"},{"key":"10.1016\/j.adro.2022.101034_bib0024","article-title":"The big idea: How to solve the cost crisis in health care","volume":"89","author":"Kaplan","year":"2011","journal-title":"Harv Bus Rev"},{"key":"10.1016\/j.adro.2022.101034_bib0025","doi-asserted-by":"crossref","unstructured":"Kim H, Lee P, Tree AC, et al. Adaptive radiation therapy physician guidelines: recommendations from an expert users\u2019 panel [e-pub ahead of print]. Pract Radiat Oncol. https:\/\/doi.org\/10.1016\/j.prro.2022.05.007, accessed June 16, 2022.","DOI":"10.1016\/j.prro.2022.05.007"},{"issue":"3 Suppl","key":"10.1016\/j.adro.2022.101034_bib0026","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.ijrobp.2009.02.090","article-title":"Radiation dose\u2013volume effects of the urinary bladder","volume":"76","author":"Viswanathan","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109422001403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109422001403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:43:36Z","timestamp":1762530216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109422001403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S2452109422001403"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2022.101034","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Online Adaptive Radiation Therapy and Opportunity Cost","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2022.101034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101034"}}