{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:20:37Z","timestamp":1790238037363,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.adro.2023.101259","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T17:34:01Z","timestamp":1683048841000},"page":"101259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cancer Control, Toxicity, and Secondary Malignancy Risks of Proton Radiation Therapy for Stage I-IIB Testicular Seminoma"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-9195","authenticated-orcid":false,"given":"Russell","family":"Maxwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Vaughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Christodouleas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2023.101259_bib0001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41572-018-0029-0","article-title":"Testicular cancer","volume":"4","author":"Cheng","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.adro.2023.101259_bib0002","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1200\/JCO.1999.17.4.1146","article-title":"Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial","volume":"17","author":"Foss\u00e5","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0003","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1200\/JCO.2003.06.065","article-title":"Radiotherapy for stages IIA\/B testicular seminoma: Final report of a prospective multicenter clinical trial","volume":"21","author":"Classen","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0004","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1038\/sj.bjc.6601867","article-title":"Para-aortic irradiation for stage I testicular seminoma: Results of a prospective study in 675 patients","volume":"90","author":"Classen","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.adro.2023.101259_bib0005","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1200\/JCO.2005.08.003","article-title":"Randomized trial of 30 versus 20 Gy in the adjuvant treatment of stage I testicular seminoma: A report on Medical Research Council Trial TE18, European Organisation for the Research and Treatment of Cancer Trial 30942 (ISRCTN18525328)","volume":"23","author":"Jones","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0006","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(05)66984-X","article-title":"Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: A randomised trial","volume":"366","author":"Oliver","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2023.101259_bib0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/COC.0b013e3182354b9e","article-title":"Improving the therapeutic ratio by using proton therapy in patients with stage I or II seminoma","volume":"36","author":"Hoppe","year":"2013","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0360-3016(03)00073-7","article-title":"Radiation-induced second cancers: The impact of 3D-CRT and IMRT","volume":"56","author":"Hall","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101259_bib0009","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.hoc.2019.08.006","article-title":"Proton therapy","volume":"33","author":"LaRiviere","year":"2019","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.adro.2023.101259_bib0010","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.ijrobp.2004.12.040","article-title":"Estimation of radiation-induced cancer from three-dimensional dose distributions: Concept of organ equivalent dose","volume":"61","author":"Schneider","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101259_bib0011","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00411-005-0016-1","article-title":"Radiation risk estimates after radiotherapy: Application of the organ equivalent dose concept to plateau dose-response relationships","volume":"44","author":"Schneider","year":"2005","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.adro.2023.101259_bib0012","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/0284186X.2017.1324207","article-title":"A review of dosimetric and toxicity modeling of proton versus photon craniospinal irradiation for pediatrics medulloblastoma","volume":"56","author":"Ho","year":"2017","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0013","doi-asserted-by":"crossref","first-page":"11","DOI":"10.14338\/IJPT-20-00018.1","article-title":"Outcomes and toxicities of proton and photon radiation therapy for testicular seminoma","volume":"7","author":"Pasalic","year":"2020","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.adro.2023.101259_bib0014","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijrobp.2010.11.021","article-title":"Predicted rates of secondary malignancies from proton versus photon radiation therapy for stage I seminoma","volume":"82","author":"Simone","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101259_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.radonc.2012.01.012","article-title":"Adjuvant radiation therapy for early stage seminoma: Proton versus photon planning comparison and modeling of second cancer risk","volume":"103","author":"Efstathiou","year":"2012","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0016","doi-asserted-by":"crossref","first-page":"50","DOI":"10.14338\/IJPT-18-00001.1","article-title":"Proton therapy for stage IIA-B seminoma: A new standard of care for treating retroperitoneal nodes","volume":"5","author":"Choo","year":"2018","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.adro.2023.101259_bib0017","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/0284186X.2011.564650","article-title":"Bone marrow-sparing intensity-modulated radiation therapy for stage I seminoma","volume":"50","author":"Zilli","year":"2011","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0018","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.bjc.6601558","article-title":"Increased mortality rates in young and middle-aged patients with malignant germ cell tumours","volume":"90","author":"Foss\u00e5","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.adro.2023.101259_bib0019","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1200\/JCO.2004.05.205","article-title":"Mortality after cure of testicular seminoma","volume":"22","author":"Zagars","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101259_bib0020","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/jnci\/dji278","article-title":"Second cancers among 40,576 testicular cancer patients: Focus on long-term survivors","volume":"97","author":"Travis","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2023.101259_bib0021","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ijrobp.2007.10.007","article-title":"Effect of radiotherapy volume and dose on secondary cancer risk in stage I testicular seminoma","volume":"70","author":"Zwahlen","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942300088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942300088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:44:14Z","timestamp":1762530254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245210942300088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S245210942300088X"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2023.101259","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer Control, Toxicity, and Secondary Malignancy Risks of Proton Radiation Therapy for Stage I-IIB Testicular Seminoma","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2023.101259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101259"}}