{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:31:01Z","timestamp":1775910661529,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001794","name":"Pediatric Brain Tumor Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["P30CA014236"],"award-info":[{"award-number":["P30CA014236"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["P50CA190991"],"award-info":[{"award-number":["P50CA190991"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["U19CA264385"],"award-info":[{"award-number":["U19CA264385"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA256045"],"award-info":[{"award-number":["K08CA256045"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R38CA24520401"],"award-info":[{"award-number":["R38CA24520401"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.adro.2023.101320","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T21:40:37Z","timestamp":1689975637000},"page":"101320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Ataxia-Telangiectasia Mutated Variants on Radionecrosis and Local Control After Stereotactic Radiation Surgery for Non-Small Cell Lung Cancer Brain Metastases"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-8453","authenticated-orcid":false,"given":"Warren","family":"Floyd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Vaios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Shenker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hendrickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justus D.","family":"Adamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trey","family":"Mullikin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Kirkpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-9550","authenticated-orcid":false,"given":"Zachary J.","family":"Reitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2023.101320_bib0001","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/8.1.69","article-title":"Characterization of ATM gene mutations in 66 ataxia telangiectasia families","volume":"8","author":"Sandoval","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.adro.2023.101320_bib0002","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.it.2021.02.001","article-title":"ATM: Translating the DNA damage response to adaptive immunity","volume":"42","author":"Weitering","year":"2021","journal-title":"Trends Immunol"},{"key":"10.1016\/j.adro.2023.101320_bib0003","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cbf.3385","article-title":"Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy","volume":"37","author":"Liang","year":"2019","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.adro.2023.101320_bib0004","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.adro.2023.101320_bib0005","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio Cancer Genomics Portal: An open platform for exploring multidimensional cancer genomics data: Figure 1","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.adro.2023.101320_bib0006","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1158\/0008-5472.CAN-04-2727","article-title":"Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM","volume":"64","author":"Hickson","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.adro.2023.101320_bib0007","first-page":"S166","article-title":"ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: Retrospective analysis using next-generation sequencing data","volume":"10","author":"Yoon","year":"2022","journal-title":"Brain Tumor Res Treat"},{"key":"10.1016\/j.adro.2023.101320_bib0008","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4143\/crt.2020.1247","article-title":"Increased radiosensitivity of solid tumors harboring ATM and BRCA1\/2 mutations","volume":"54","author":"Kim","year":"2022","journal-title":"Cancer Res Treat"},{"key":"10.1016\/j.adro.2023.101320_bib0009","doi-asserted-by":"crossref","first-page":"S226","DOI":"10.1016\/j.ijrobp.2018.07.155","article-title":"Pathogenic mutations in ATM as determinants of local control in non-small cell lung cancers treated with radiation therapy","volume":"102","author":"Pitter","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101320_bib0010","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139333","article-title":"ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS\/STING activation","volume":"131","author":"Hu","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.adro.2023.101320_bib0011","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2018.07.034","article-title":"Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-\u03baB signaling after nuclear DNA damage","volume":"71","author":"Dunphy","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.adro.2023.101320_bib0012","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3389\/fonc.2020.00781","article-title":"Tumor primary site and histology subtypes role in radiotherapeutic management of brain metastases","volume":"10","author":"Khan","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2023.101320_bib0013","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/jnci\/djaa095","article-title":"Pathogenic ATM mutations in cancer and a genetic basis for radiotherapeutic efficacy","volume":"113","author":"Pitter","year":"2020","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2023.101320_bib0014","first-page":"36","article-title":"Targeted therapy for non-small cell lung cancer: Current standards and the promise of the future","volume":"4","author":"Chan","year":"2015","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.adro.2023.101320_bib0015","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/cncr.23533","article-title":"Prognostic significance ofataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer","volume":"112","author":"Xing","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2023.101320_bib0016","article-title":"Implementation of a molecular tumor registry to support the adoption of precision oncology within an academic medical center: The Duke University experience","volume":"5","author":"Green","year":"2021","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.adro.2023.101320_bib0017","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.adro.2017.09.002","article-title":"Single fraction stereotactic radiosurgery for multiple brain metastases","volume":"2","author":"Limon","year":"2017","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2023.101320_bib0018","series-title":"Image-Guided Hypofractionated Stereotactic Radiosurgery","first-page":"243","article-title":"Brain metastases image-guided hypofractionated radiation therapy: Rationale, approach, outcomes","author":"Usuki","year":"2016"},{"key":"10.1016\/j.adro.2023.101320_bib0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","article-title":"Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05","volume":"47","author":"Shaw","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101320_bib0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/2531021","article-title":"Sample-size formula for the proportional-hazards regression model","volume":"39","author":"Schoenfeld","year":"1983","journal-title":"Biometrics"},{"key":"10.1016\/j.adro.2023.101320_bib0021","unstructured":"Kohn MA, Senyak J. Sample size calculators [website]. UCSF CTSI. April 29, 2021. Available at: https:\/\/sample-size.net\/. Accessed February 10, 2022."},{"key":"10.1016\/j.adro.2023.101320_bib0022","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1200\/JCO.2005.03.145","article-title":"Current management of brain metastases, with a focus on systemic options","volume":"23","author":"Langer","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101320_bib0023","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142158","article-title":"Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models","volume":"131","author":"Deland","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.adro.2023.101320_bib0024","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.18632\/aging.103094","article-title":"ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy","volume":"12","author":"Mou","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.adro.2023.101320_bib0025","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1158\/1078-0432.CCR-18-1201","article-title":"Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays","volume":"24","author":"Coombs","year":"2018","journal-title":"Clin Cancer Res"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109423001483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109423001483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:43:46Z","timestamp":1762530226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109423001483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2452109423001483"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2023.101320","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Ataxia-Telangiectasia Mutated Variants on Radionecrosis and Local Control After Stereotactic Radiation Surgery for Non-Small Cell Lung Cancer Brain Metastases","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2023.101320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101320"}}