{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:12:17Z","timestamp":1793473937749,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.adro.2023.101418","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T21:44:19Z","timestamp":1702158259000},"page":"101418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adjuvant Reirradiation With Proton Therapy in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-473X","authenticated-orcid":false,"given":"Kristin","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Elena","family":"Hotca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Dickstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Lehrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal K.","family":"Sindhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry T.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit","family":"Chhabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Misiukiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Roof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohemmed Nazir","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kirke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Urken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Posner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Genden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-7878","authenticated-orcid":false,"given":"Richard L.","family":"Bakst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2023.101418_bib0001","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hed.26548","article-title":"Treatment tolerability and outcomes in elderly patients with head and neck cancer","volume":"43","author":"Dickstein","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.adro.2023.101418_bib0002","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/CCO.0000000000000629","article-title":"Epidemiology of head and neck cancers: An update","volume":"32","author":"Aup\u00e9rin","year":"2020","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0003","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41571-019-0227-z","article-title":"The changing therapeutic landscape of head and neck cancer","volume":"16","author":"Cramer","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0004","unstructured":"National Comprehensive Cancer Network. Head and neck cancers (version 02.2022). Accessed December 5, 2022. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf"},{"key":"10.1016\/j.adro.2023.101418_bib0005","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.3390\/cancers13102371","article-title":"Recurrent\/metastatic squamous cell carcinoma of the head and neck: A big and intriguing challenge which may be resolved by integrated treatments combining locoregional and systemic therapies","volume":"13","author":"Ionna","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2023.101418_bib0006","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/jamaoto.2018.0993","article-title":"Incidence and risk of second primary malignant neoplasm after a first head and neck squamous cell carcinoma","volume":"144","author":"Adjei Boakye","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.adro.2023.101418_bib0007","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1159\/000513617","article-title":"Treatment modality and second primary tumors of the head and neck","volume":"83","author":"Ben Arie","year":"2021","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.adro.2023.101418_bib0008","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41698-019-0097-y","article-title":"Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy","volume":"3","author":"Ng","year":"2019","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0009","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.3390\/cancers13133173","article-title":"Re-Irradiation for head and neck cancer: Cumulative dose to organs at risk and late side effects","volume":"13","author":"Embring","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2023.101418_bib0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/hed.23542","article-title":"Recurrent and second primary squamous cell carcinoma of the head and neck: When and how to reirradiate","volume":"37","author":"Strojan","year":"2015","journal-title":"Head Neck"},{"key":"10.1016\/j.adro.2023.101418_bib0011","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hed.26898","article-title":"Salvage surgery for recurrent squamous cell carcinoma of the head and neck: Systematic review and meta-analysis","volume":"44","author":"Bulbul","year":"2022","journal-title":"Head Neck"},{"key":"10.1016\/j.adro.2023.101418_bib0012","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1177\/0194599818818443","article-title":"Salvage surgery for recurrence after radiotherapy for squamous cell carcinoma of the head and neck","volume":"160","author":"Elbers","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.adro.2023.101418_bib0013","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.oraloncology.2004.07.006","article-title":"A review on re-irradiation for recurrent and second primary head and neck cancer","volume":"41","author":"Kasperts","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103550","article-title":"Prognostic factors in salvage surgery for recurrent head and neck cancer: A systematic review and meta-analysis","volume":"169","author":"Lupato","year":"2022","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.adro.2023.101418_bib0015","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.ijrobp.2004.08.029","article-title":"Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy","volume":"61","author":"Milano","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0016","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brachy.2005.11.003","article-title":"Perioperative high-dose-rate brachytherapy (PHDRB) in previously irradiated head and neck cancer: Initial results of a phase I\/II reirradiation study","volume":"5","author":"Mart\u00ednez-Monge","year":"2006","journal-title":"Brachytherapy"},{"key":"10.1016\/j.adro.2023.101418_bib0017","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.radonc.2016.08.020","article-title":"Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial","volume":"121","author":"Eekers","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0018","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.50607","article-title":"Evaluation of proton therapy reirradiation for patients with recurrent head and neck squamous cell carcinoma","volume":"6","author":"Lee","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.adro.2023.101418_bib0019","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijrobp.2016.02.036","article-title":"Proton beam reirradiation for recurrent head and neck cancer: Multi-institutional report on feasibility and early outcomes","volume":"95","author":"Romesser","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijrobp.2016.03.053","article-title":"Reirradiation of head and neck cancers with proton therapy: outcomes and analyses","volume":"96","author":"Phan","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2017.08.005","article-title":"Systematic assessment of clinical outcomes and toxicities of proton radiotherapy for reirradiation","volume":"125","author":"Verma","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0022","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1200\/JCO.2014.55.3925","article-title":"Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: Long-term report of efficacy and toxicity","volume":"32","author":"Nguyen-Tan","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0023","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1200\/JCO.2012.43.6097","article-title":"Long-term results of RTOG 91-11: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer","volume":"31","author":"Forastiere","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.radonc.2021.04.011","article-title":"Impact of radiation-induced toxicities on quality of life of patients treated for head and neck cancer","volume":"160","author":"van der Laan","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0025","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ijrobp.2022.03.034","article-title":"Retreatment of recurrent or second primary head and neck cancer after prior radiation: Executive summary of the American Radium Society appropriate use criteria","volume":"113","author":"Ward","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0026","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.3390\/cancers13194912","article-title":"An updated review on head and neck cancer treatment with radiation therapy","volume":"13","author":"Anderson","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2023.101418_bib0027","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/hed.26490","article-title":"Systematic review of postoperative therapy for resected squamous cell carcinoma of the head and neck: Executive summary of the American Radium Society appropriate use criteria","volume":"43","author":"Margalit","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.adro.2023.101418_bib0028","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.oraloncology.2018.11.010","article-title":"High-risk pathological features at the time of salvage surgery predict poor survival after definitive therapy in patients with head and neck squamous cell carcinoma","volume":"88","author":"Haque","year":"2019","journal-title":"Oral Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0029","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and neck cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2023.101418_bib0030","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1200\/JCO.2007.15.0102","article-title":"Randomized trial of postoperative reirradiation combined with chemotherapy after salvage surgery compared with salvage surgery alone in head and neck carcinoma","volume":"26","author":"Janot","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0031","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.ijrobp.2012.05.008","article-title":"Long-term follow-up of the RTOG 9501\/intergroup phase III trial: Postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck","volume":"84","author":"Cooper","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0032","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/cncr.21768","article-title":"Results of postoperative reirradiation for recurrent or second primary head and neck carcinoma","volume":"106","author":"Kasperts","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2023.101418_bib0033","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/1097-0142(20010601)91:11<2071::AID-CNCR1234>3.0.CO;2-Z","article-title":"Full dose reirradiation combined with chemotherapy after salvage surgery in head and neck carcinoma","volume":"91","author":"De Crevoisier","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2023.101418_bib0034","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.ejso.2020.01.019","article-title":"Salvage surgery in head and neck cancer: Does it improve outcomes?","volume":"46","author":"Patil","year":"2020","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0035","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41598-020-79759-0","article-title":"A pre-operative prognostic score for the selection of patients for salvage surgery after recurrent head and neck squamous cell carcinomas","volume":"11","author":"Lupato","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.adro.2023.101418_bib0036","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1200\/JCO.2006.07.9194","article-title":"Phase II study of low-dose paclitaxel and cisplatin in combination with split-course concomitant twice-daily reirradiation in recurrent squamous cell carcinoma of the head and neck: Results of Radiation Therapy Oncology Group Protocol 9911","volume":"25","author":"Langer","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2023.101418_bib0037","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijrobp.2008.04.021","article-title":"IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes","volume":"73","author":"Sulman","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0038","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ijrobp.2006.12.055","article-title":"Salvage re-irradiation for recurrent head and neck cancer","volume":"68","author":"Lee","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2023.101418_bib0039","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.ijrobp.2007.04.057","article-title":"Intensity-modulated radiotherapy with concurrent chemotherapy for previously irradiated, recurrent head and neck cancer","volume":"69","author":"Biagioli","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109423002464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109423002464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:45:32Z","timestamp":1762530332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109423002464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S2452109423002464"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2023.101418","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjuvant Reirradiation With Proton Therapy in Head and Neck Squamous Cell Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2023.101418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101418"}}