{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:29:22Z","timestamp":1786984162649,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","advancesradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.adro.2024.101632","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:21:03Z","timestamp":1727662863000},"page":"101632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rotationally Intensified Proton Lattice: A Novel Lattice Technique Using Spot-Scanning Proton Arc Therapy"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-1723","authenticated-orcid":false,"given":"Joseph S.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Mumaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey A.","family":"Loving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebin","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoda","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F.","family":"Loughery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Deraniyagala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muayad F.","family":"Almahariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanfeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-2640","authenticated-orcid":false,"given":"Thomas J.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2024.101632_bib0001","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ijrobp.2020.03.028","article-title":"Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy","volume":"107","author":"Griffin","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0002","article-title":"An international consensus on the design of prospective clinical-translational trials in spatially fractionated radiation therapy","volume":"7","author":"Mayr","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.radonc.2021.11.023","article-title":"Lite sabr m1: A phase I trial of lattice stereotactic body radiotherapy for large tumors","volume":"167","author":"Duriseti","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0004","article-title":"Spatially fractionated stereotactic body radiation therapy (lattice) for large tumors","volume":"6","author":"Duriseti","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0005","first-page":"68","article-title":"Improved outcome of treating locally advanced lung cancer with the use of lattice radiotherapy (lrt): a case report","volume":"9","author":"Amendola","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0006","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1667\/RADE-20-00038.1","article-title":"Spatially fractionated radiation therapy using lattice radiation in far-advanced bulky cervical cancer: a clinical and molecular imaging and outcome study","volume":"194","author":"Amendola","year":"2020","journal-title":"Radiat Res"},{"key":"10.1016\/j.adro.2024.101632_bib0007","first-page":"11","article-title":"Safety and efficacy of lattice radiotherapy in voluminous non-small cell lung cancer","author":"Amendola","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.adro.2024.101632_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1227-y","article-title":"Novel stereotactic body radiation therapy (sbrt)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (sbrt-pathy): Improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects","volume":"14","author":"Tubin","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0009","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.3390\/cancers14163909","article-title":"Impressive results after \"Metabolism-guided\" Lattice irradiation in patients submitted to palliative radiation therapy: preliminary results of lattice_01 multicenter study","volume":"14","author":"Ferini","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2024.101632_bib0010","article-title":"Spatially fractionated radiation therapy in sarcomas: A large single-institution experience","volume":"9","author":"Ahmed","year":"2024","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0011","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1667\/RR3819.1","article-title":"In vivo effects of lattice radiation therapy on local and distant lung cancer: potential role of immunomodulation","volume":"182","author":"Kanagavelu","year":"2014","journal-title":"Radiat Res"},{"key":"10.1016\/j.adro.2024.101632_bib0012","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijrobp.2019.01.073","article-title":"A current review of spatial fractionation: Back to the future?","volume":"104","author":"Billena","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0013","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3390\/ijms23063366","article-title":"Radiobiological and treatment-related aspects of spatially fractionated radiotherapy","volume":"23","author":"Moghaddasi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.adro.2024.101632_bib0014","article-title":"Combined high-dose lattice radiation therapy and immune checkpoint blockade for advanced bulky tumors: the concept and a case report","volume":"10","author":"Jiang","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0015","first-page":"e417","article-title":"High-dose radiation as a dramatic, immunological primer in locally advanced melanoma","volume":"7","author":"Mohiuddin","year":"2015","journal-title":"Cureus"},{"key":"10.1016\/j.adro.2024.101632_bib0016","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1016\/S1470-2045(14)70412-7","article-title":"Carbon ion radiotherapy in japan: an assessment of 20 years of clinical experience","volume":"16","author":"Kamada","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0017","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1038\/s41598-021-92942-1","article-title":"Impact of proton therapy on antitumor immune response","volume":"11","author":"Mirjolet","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.adro.2024.101632_bib0018","article-title":"On modern technical approaches of three-dimensional high-dose lattice radiotherapy (LRT)","volume":"2","author":"Wu","year":"2010","journal-title":"Cureus"},{"key":"10.1016\/j.adro.2024.101632_bib0019","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1667\/RADE-20-00066.1","article-title":"The technical and clinical implementation of lattice radiation therapy (lrt)","volume":"194","author":"Wu","year":"2020","journal-title":"Radiat Res"},{"key":"10.1016\/j.adro.2024.101632_bib0020","article-title":"Lattice radiation therapy in clinical practice: a systematic review","volume":"39","author":"Iori","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0021","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1016\/j.prro.2022.03.005","article-title":"A dosimetric comparison of lattice, brass, and proton grid therapy treatment plans","volume":"12","author":"Grams","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0022","doi-asserted-by":"crossref","first-page":"467","DOI":"10.21037\/atm-21-6631","article-title":"Feasibility of lattice radiotherapy using proton and carbon-ion pencil beam for sinonasal malignancy","volume":"10","author":"Yang","year":"2022","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.adro.2024.101632_bib0023","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1002\/mp.16572","article-title":"Lattice position optimization for lattice therapy","volume":"50","author":"Zhang","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0024","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ijrobp.2016.08.049","article-title":"Spot-scanning proton arc (sparc) therapy: The first robust and delivery-efficient spot-scanning proton arc therapy","volume":"96","author":"Ding","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13014-018-0981-6","article-title":"Improve dosimetric outcome in stage iii non-small-cell lung cancer treatment using spot-scanning proton arc (sparc) therapy","volume":"13","author":"Li","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0026","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13014-020-01676-3","article-title":"Feasibility study: spot-scanning proton arc therapy (sparc) for left-sided whole breast radiotherapy","volume":"15","author":"Chang","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0027","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/0284186X.2018.1555374","article-title":"Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy","volume":"58","author":"Ding","year":"2019","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13014-020-1476-9","article-title":"Improve the dosimetric outcome in bilateral head and neck cancer (hnc) treatment using spot-scanning proton arc (sparc) therapy: a feasibility study","volume":"15","author":"Liu","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0029","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/0284186X.2021.1892183","article-title":"Is proton beam therapy ready for single fraction spine sbrs?\u2014a feasibility study to use spot-scanning proton arc (sparc) therapy to improve the robustness and dosimetric plan quality","volume":"60","author":"Liu","year":"2021","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0030","article-title":"Lung stereotactic body radiotherapy (sbrt) using spot-scanning proton arc (sparc) therapy: a feasibility study","volume":"11","author":"Liu","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0031","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.radonc.2019.04.032","article-title":"The first prototype of spot-scanning proton arc treatment delivery","volume":"137","author":"Li","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0032","first-page":"68","article-title":"The first investigation of spot-scanning proton arc (sparc) delivery time and accuracy with different delivery tolerance window settings","author":"Liu","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.adro.2024.101632_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105609","article-title":"Treatment planning in arc proton therapy: Comparison of several optimization problem statements and their corresponding solvers","volume":"148","author":"Wuyckens","year":"2022","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.adro.2024.101632_bib0034","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2021.12.003","article-title":"Lite sabr m1: Planning design and dosimetric endpoints for a phase I trial of lattice sbrt","volume":"167","author":"Kavanaugh","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ijrobp.2023.08.061","article-title":"Dosimetric validation for prospective clinical trial of grid collimator-based spatially fractionated radiation therapy: dose metrics consistency and heterogeneous pattern reproducibility","volume":"118","author":"Zhang","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0036","doi-asserted-by":"crossref","DOI":"10.1118\/1.3469279","article-title":"Tu-d-202-01: Overview of the aapm tg 101","volume":"37","author":"Benedict","year":"2010","journal-title":"Med Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0037","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/0284186X.2020.1765415","article-title":"A novel energy sequence optimization algorithm for efficient spot-scanning proton arc (sparc) treatment delivery","volume":"59","author":"Liu","year":"2020","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0038","article-title":"Normal tissue integral dose as a result of prostate radiation therapy: A quantitative comparison between high-dose-rate brachytherapy and modern external beam radiation therapy techniques","volume":"8","author":"Grzywacz","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0039","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1002\/mp.16879","article-title":"Development of a standalone delivery sequence model for proton arc therapy","volume":"51","author":"Liu","year":"2024","journal-title":"Med Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0040","first-page":"67","article-title":"Building a precise machine-specific time structure of the spot and energy delivery model for a cyclotron-based proton therapy system","author":"Zhao","year":"2022","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.adro.2024.101632_bib0041","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13014-022-02055-w","article-title":"Developing an accurate model of spot-scanning treatment delivery time and sequence for a compact superconducting synchrocyclotron proton therapy system","volume":"17","author":"Zhao","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.adro.2023.101308","article-title":"Practice patterns of spatially fractionated radiation therapy: A clinical practice survey","author":"Mayr","year":"2024","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0043","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijrobp.2023.12.013","article-title":"Overview and recommendations for prospective multi-institutional spatially fractionated radiation therapy clinical trials","volume":"119","author":"Li","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0044","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/j.prro.2020.10.007","article-title":"Vmat grid therapy: a widely applicable planning approach","volume":"11","author":"Grams","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0045","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.3390\/cancers14174267","article-title":"An international consensus on the design of prospective clinical-translational trials in spatially fractionated radiation therapy for advanced gynecologic cancer","volume":"14","author":"Amendola","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2024.101632_bib0046","article-title":"Combining spatially fractionated radiation therapy (sfrt) and immunotherapy opens new rays of hope for enhancing therapeutic ratio","volume":"44","author":"Lu","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101632_bib0047","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002038","article-title":"Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?","volume":"9","author":"Demaria","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.adro.2024.101632_bib0048","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ijrobp.2020.09.041","article-title":"Reduction of lung metastases in a mouse osteosarcoma model treated with carbon ions and immune checkpoint inhibitors","volume":"109","author":"Helm","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101632_bib0049","doi-asserted-by":"crossref","first-page":"180","DOI":"10.21037\/tlcr.2018.03.28","article-title":"Proton beam therapy and immunotherapy: an emerging partnership for immune activation in non-small cell lung cancer","volume":"7","author":"Lee","year":"2018","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.adro.2024.101632_bib0050","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00066-023-02158-7","article-title":"High-let charged particles: Radiobiology and application for new approaches in radiotherapy","volume":"199","author":"Helm","year":"2023","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.adro.2024.101632_bib0051","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.ijrobp.2023.12.041","article-title":"Temporal evolution and diagnostic diversification of patients receiving proton therapy in the united states: A ten-year trend analysis (2012 to 2021) from the national association for proton therapy","volume":"119","author":"Hartsell","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109424001957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109424001957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:35:09Z","timestamp":1731663309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109424001957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2452109424001957"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2024.101632","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rotationally Intensified Proton Lattice: A Novel Lattice Technique Using Spot-Scanning Proton Arc Therapy","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2024.101632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101632"}}