{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:08:35Z","timestamp":1785089315085,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022506699"],"award-info":[{"award-number":["2022506699"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","advancesradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.adro.2024.101646","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T21:44:47Z","timestamp":1727473487000},"page":"101646","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dosimetric Evaluation of Hippocampus Sparing Intensity Modulated Radiation Therapy in Patients With Stage T1-T2 and Stage T3-T4 Nasopharyngeal Carcinoma"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9434-178X","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanghua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-5000","authenticated-orcid":false,"given":"Qichun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2024.101646_bib0001","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1200\/JCO.20.03237","article-title":"Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline","volume":"39","author":"Chen","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0002","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20130474","article-title":"Evaluation of hippocampus dose for patients undergoing intensity-modulated radiotherapy for nasopharyngeal carcinoma","volume":"87","author":"Khodayari","year":"2014","journal-title":"Br J Radiol"},{"key":"10.1016\/j.adro.2024.101646_bib0003","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/neuonc\/nos303","article-title":"Association between radiation dose to neuronal progenitor cell niches and temporal lobes and performance on neuropsychological testing in children: A prospective study","volume":"15","author":"Redmond","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0004","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1200\/JCO.2014.57.2909","article-title":"Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial","volume":"32","author":"Gondi","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1470-2045(11)70303-5","article-title":"Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): A phase 2 multi-institutional trial","volume":"13","author":"Lee","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0006","first-page":"267","article-title":"Committee on clinical staging of nasopharyngeal carcinoma in China. The consensus on the target's delineation for NPC among Chinese experts 2010","volume":"20","year":"2011","journal-title":"Chin J Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0007","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/COC.0b013e318178e4e8","article-title":"A radiation oncologist's guide to contouring the hippocampus","volume":"32","author":"Chera","year":"2009","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0008","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.radonc.2010.02.030","article-title":"Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: Safety profile for RTOG 0933","volume":"95","author":"Gondi","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0009","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijrobp.2005.09.028","article-title":"Conformity index: A review","volume":"64","author":"Feuvret","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101646_bib0010","doi-asserted-by":"crossref","first-page":"e90007","DOI":"10.1371\/journal.pone.0090007","article-title":"Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.adro.2024.101646_bib0011","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.rpor.2019.12.012","article-title":"Dosimetric impact on changes in target volumes during intensity-modulated radiotherapy for nasopharyngeal carcinoma","volume":"25","author":"Mnejja","year":"2020","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.adro.2024.101646_bib0012","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3892\/ol.2017.6199","article-title":"Dynamic MRI follow-up of radiation encephalopathy in the temporal lobe following nasopharyngeal carcinoma radiotherapy","volume":"14","author":"Zhou","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.adro.2024.101646_bib0013","first-page":"36","article-title":"Temporal lobe microstructural abnormalities in patients with nasopharyngeal carcinoma quantitatively evaluated by high-resolution DWI and DKI after concurrent chemoradiotherapy","volume":"21","author":"Wu","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0014","first-page":"477","article-title":"Changes in brain gray matter volume in nasopharyngeal carcinoma patients after radiotherapy in long-term follow-up","volume":"89","author":"Zhu","year":"2023","journal-title":"Braz J Orl"},{"key":"10.1016\/j.adro.2024.101646_bib0015","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1200\/JCO.2008.19.9109","article-title":"Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: Radiation Therapy Oncology Group phase II trial 0225","volume":"27","author":"Lee","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0016","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijrobp.2019.06.2540","article-title":"International guideline on dose prioritization and acceptance criteria in radiation therapy planning for nasopharyngeal carcinoma","volume":"105","author":"Lee","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101646_bib0017","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.radonc.2016.12.013","article-title":"Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study","volume":"122","author":"Pospisil","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0018","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ijrobp.2015.08.014","article-title":"A radiation-induced hippocampal vascular injury surrogate marker predicts late neurocognitive dysfunction","volume":"93","author":"Farjam","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101646_bib0019","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijrobp.2016.10.035","article-title":"Radiation dose-dependent hippocampal atrophy detected with longitudinal volumetric magnetic resonance imaging","volume":"97","author":"Seibert","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2024.101646_bib0020","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/hipo.22758","article-title":"Smaller hippocampal subfield volumes predict verbal associative memory in pediatric brain tumor survivors","volume":"27","author":"Decker","year":"2017","journal-title":"Hippocampus"},{"key":"10.1016\/j.adro.2024.101646_bib0021","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1148\/radiol.11101975","article-title":"Mild cognitive impairment: Baseline and longitudinal structural MR imaging measures improve predictive prognosis","volume":"259","author":"McEvoy","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.adro.2024.101646_bib0022","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuroimage.2015.10.065","article-title":"Integrating longitudinal information in hippocampal volume measurements for the early detection of Alzheimer's disease","volume":"125","author":"Chincarini","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.adro.2024.101646_bib0023","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1038\/s41598-017-03517-y","article-title":"The hippocampus sparing volume modulated arc therapy does not influence plan quality on locally advanced nasopharyngeal carcinoma patients","volume":"7","author":"Gu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.adro.2024.101646_bib0024","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3109\/02841869609083995","article-title":"Pathogenesis of irradiation-induced cognitive dysfunction","volume":"35","author":"Abayomi","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0025","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0306-4522(03)00199-4","article-title":"Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat","volume":"119","author":"Madsen","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.adro.2024.101646_bib0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1667\/RR3206","article-title":"Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis","volume":"162","author":"Raber","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.adro.2024.101646_bib0027","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A functional role for adult hippocampal neurogenesis in spatial pattern separation","volume":"325","author":"Clelland","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.adro.2024.101646_bib0028","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1158\/1078-0432.CCR-11-2903","article-title":"Molecular pathways: Radiation-induced cognitive impairment","volume":"19","author":"Greene-Schloesser","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.adro.2024.101646_bib0029","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/S1470-2045(18)30938-0","article-title":"Pharmacologic management of cognitive impairment induced by cancer therapy","volume":"20","author":"Karschnia","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2024.101646_bib0030","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1056\/NEJMra1716145","article-title":"Stem cells in the treatment of disease","volume":"380","author":"Blau","year":"2019","journal-title":"N Engl J Med"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109424002094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109424002094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T14:35:20Z","timestamp":1731681320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109424002094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2452109424002094"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2024.101646","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dosimetric Evaluation of Hippocampus Sparing Intensity Modulated Radiation Therapy in Patients With Stage T1-T2 and Stage T3-T4 Nasopharyngeal Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2024.101646","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101646"}}