{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:10:17Z","timestamp":1791976217355,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","advancesradonc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.adro.2025.101758","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T12:48:02Z","timestamp":1744375682000},"page":"101758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification and Dosimetric Impact of Normal Organ Motion During Adaptive Radiation Therapy Planning Using a 1.5 Tesla Magnetic Resonance\u2013Equipped Linear Accelerator (MR-Linac)"],"prefix":"10.1016","volume":"10","author":[{"given":"David","family":"Wittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjishnu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leou Ismael","family":"Banla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musaddiq","family":"Awan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eenas A.","family":"Omari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Straza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Allen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Erickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-6755","authenticated-orcid":false,"given":"William A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101758_bib0001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejca.2019.07.021","article-title":"The transformation of radiation oncology using real-time magnetic resonance guidance: A review","volume":"122","author":"Hall","year":"2019","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.adro.2025.101758_bib0002","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3322\/caac.21707","article-title":"Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians","volume":"72","author":"Hall","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.adro.2025.101758_bib0003","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.3390\/jcm11144044","article-title":"Towards accurate and precise image-guided radiotherapy: Clinical applications of the MR-Linac","volume":"11","author":"Randall","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.adro.2025.101758_bib0004","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13014-020-01524-4","article-title":"Medical physics challenges in clinical MR-guided radiotherapy","volume":"15","author":"Kurz","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13014-022-02021-6","article-title":"Dosimetric benefit of MR-guided online adaptive radiotherapy in different tumor entities: Liver, lung, abdominal lymph nodes, pancreas and prostate","volume":"17","author":"Nierer","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0006","article-title":"Initial clinical experience of stereotactic body radiation therapy (SBRT) for liver metastases, primary liver malignancy, and pancreatic cancer with 4D-MRI based online adaptation and real-time MRI monitoring using a 1.5 Tesla MR-Linac","volume":"15","author":"Hall","year":"2020","journal-title":"PLOS One"},{"key":"10.1016\/j.adro.2025.101758_bib0007","first-page":"72","article-title":"4D-MRI driven MR-guided online adaptive radiotherapy for abdominal stereotactic body radiation therapy on a high field MR-Linac: Implementation and initial clinical experience","volume":"23","author":"Paulson","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0008","first-page":"54","article-title":"Adaptive radiotherapy: The Elekta Unity MR-linac concept","volume":"18","author":"Winkel","year":"2019","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0009","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ijrobp.2020.10.021","article-title":"Adaptive radiation therapy (ART) strategies and technical considerations: A state of the art review from NRG oncology","volume":"109","author":"Glide-Hurst","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s13014-021-01916-0","article-title":"Intrafractional stability of MR-guided online adaptive SBRT for prostate cancer","volume":"16","author":"Schaule","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0011","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejmp.2020.07.027","article-title":"Assessment of online adaptive MR-guided stereotactic body radiotherapy of liver cancers","volume":"77","author":"Padgett","year":"2020","journal-title":"Phys Med"},{"key":"10.1016\/j.adro.2025.101758_bib0012","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1016\/j.prro.2018.08.010","article-title":"Dosimetric benefits and practical pitfalls of daily online adaptive MRI-guided stereotactic radiation therapy for pancreatic cancer","volume":"9","author":"El-Bared","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0013","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13014-021-01813-6","article-title":"Benefit of replanning in MR-guided online adaptive radiation therapy in the treatment of liver metastasis","volume":"16","author":"Mayinger","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0014","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.3390\/cancers14246041","article-title":"Dosimetric benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy of liver metastases","volume":"14","author":"Weykamp","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2025.101758_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tipsro.2020.06.001","article-title":"On-line adaptive MR guided radiotherapy for locally advanced pancreatic cancer: Clinical and dosimetric considerations","volume":"15","author":"Placidi","year":"2020","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0016","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tipsro.2022.08.005","article-title":"Impact of intrafraction changes in delivered dose of the day for prostate cancer patients treated with stereotactic body radiotherapy via MR-Linac","volume":"23","author":"Dang","year":"2022","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.radonc.2022.09.004","article-title":"Clinical application of a sub-fractionation workflow for intrafraction re-planning during prostate radiotherapy treatment on a 1.5 Tesla MR-Linac: A practical method to mitigate intrafraction motion","volume":"176","author":"Willigenburg","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0018","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejmp.2020.09.026","article-title":"Adaptive SBRT by 1.5 T MR-linac for prostate cancer: On the accuracy of dose delivery in view of the prolonged session time","volume":"80","author":"Ruggieri","year":"2020","journal-title":"Phys Med"},{"key":"10.1016\/j.adro.2025.101758_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2022.109441","article-title":"SBRT focal dose intensification using an MR-Linac adaptive planning for intermediate-risk prostate cancer: An analysis of the dosimetric impact of intra-fractional organ changes","volume":"179","author":"Brennan","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.31557\/APJCP.2019.20.1.229","article-title":"Application of aSi-kVCBCT for volume assessment and dose estimation: An offline adaptive study for prostate radiotherapy","volume":"20","author":"Gandhi","year":"2019","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.adro.2025.101758_bib0021","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1120\/jacmp.v17i6.6207","article-title":"Dosimetric and volumetric changes in the rectum and bladder in patients receiving CBCT-guided prostate IMRT: Analysis based on daily CBCT dose calculation","volume":"17","author":"Pearson","year":"2016","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0022","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijrobp.2018.06.002","article-title":"Role of daily plan adaptation in MR-guided stereotactic ablative radiation therapy for adrenal metastases","volume":"102","author":"Palacios","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0023","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijrobp.2009.04.046","article-title":"Interfraction and respiratory organ motion during conformal radiotherapy in gastric cancer","volume":"77","author":"Wysocka","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205917","article-title":"Variations of MRI-assessed peristaltic motions during radiation therapy","volume":"13","author":"Mostafaei","year":"2018","journal-title":"PLOS One"},{"key":"10.1016\/j.adro.2025.101758_bib0025","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ijrobp.2019.03.035","article-title":"Role of on-table plan adaptation in MR-guided ablative radiation therapy for central lung tumors","volume":"104","author":"Finazzi","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0026","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.ijrobp.2018.06.022","article-title":"In silico trial of MR-guided midtreatment adaptive planning for hypofractionated stereotactic radiation therapy in centrally located thoracic tumors","volume":"102","author":"Henke","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0027","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/1748-717X-9-192","article-title":"The analysis of respiration-induced pancreatic tumor motion based on reference measurement","volume":"9","author":"Knybel","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0028","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ijrobp.2016.07.011","article-title":"Head and neck margin reduction with adaptive radiation therapy: Robustness of treatment plans against anatomy changes","volume":"96","author":"van Kranen","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101758_bib0029","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13014-018-1000-7","article-title":"Optimization of treatment planning workflow and tumor coverage during daily adaptive magnetic resonance image guided radiation therapy (MR-IGRT) of pancreatic cancer","volume":"13","author":"Olberg","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0030","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1016\/j.prro.2019.07.018","article-title":"Australasian Gastrointestinal Trials Group (AGITG) and Trans-Tasman Radiation Oncology Group (TROG) guidelines for pancreatic stereotactic body radiation therapy (SBRT)","volume":"10","author":"Oar","year":"2020","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101758_bib0031","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00066-020-01603-1","article-title":"Definition and quality requirements for stereotactic radiotherapy: Consensus statement from the DEGRO\/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery","volume":"196","author":"Guckenberger","year":"2020","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.adro.2025.101758_bib0032","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/oxfordjournals.humrep.a136966","article-title":"An evaluation of semen analysis and in-vitro tests of sperm function in the prediction of the outcome of intrauterine AIH","volume":"4","author":"Bolton","year":"1989","journal-title":"Hum Reprod"},{"key":"10.1016\/j.adro.2025.101758_bib0033","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab37a9","article-title":"Intra-fraction motion prediction in MRI-guided radiation therapy using Markov processes","volume":"64","author":"Ali Mirzapour","year":"2019","journal-title":"Phys Med Biol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T09:14:18Z","timestamp":1747214058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109425000466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2452109425000466"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101758","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification and Dosimetric Impact of Normal Organ Motion During Adaptive Radiation Therapy Planning Using a 1.5 Tesla Magnetic Resonance\u2013Equipped Linear Accelerator (MR-Linac)","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101758"}}