{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:45:06Z","timestamp":1777931106365,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K17138"],"award-info":[{"award-number":["19K17138"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.adro.2025.101760","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:57:02Z","timestamp":1745567822000},"page":"101760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phase 2 Trial of Stereotactic Body Radiation Therapy with Dose Escalation Using Simultaneous Integrated Boost for Spinal Metastases"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-3106","authenticated-orcid":false,"given":"Takamasa","family":"Mitsuyoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.\u202fK.","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Kokubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Inoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Nasada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Arizono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Imagumbai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kokubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101760_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007632-199001000-00001","article-title":"Spinal metastases: The obvious, the occult, and the impostors","volume":"15","author":"Wong","year":"1990","journal-title":"Spine"},{"key":"10.1016\/j.adro.2025.101760_bib0002","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.3390\/jcm13123590","article-title":"Comprehensive insights into metastasis-associated spinal cord compression: Pathophysiology, diagnosis, treatment, and prognosis: A state-of-the-art systematic review","volume":"13","author":"Vavourakis","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.adro.2025.101760_bib0003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.prro.2016.08.001","article-title":"Palliative radiation therapy for bone metastases: update of an ASTRO Evidence-Based Guideline","volume":"7","author":"Lutz","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0004","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.prro.2024.04.018","article-title":"External beam radiation therapy for palliation of symptomatic bone metastases: An ASTRO clinical practice guideline","volume":"14","author":"Alcorn","year":"2024","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713618","article-title":"Targeted therapy for cancers: From ongoing clinical trials to FDA-approved drugs","volume":"24","author":"Choi","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.adro.2025.101760_bib0006","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/cpt.1956","article-title":"Relationship between progression-free survival, objective response rate, and overall survival in clinical trials of PD-1\/PD-L1 immune checkpoint blockade: A meta-analysis","volume":"108","author":"Ye","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.adro.2025.101760_bib0007","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/jamaoncol.2019.5351","article-title":"Stereotactic ablative radiotherapy for the management of spinal metastases: A review","volume":"6","author":"Glicksman","year":"2020","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109966","article-title":"ESTRO clinical practice guideline: Stereotactic body radiotherapy for spine metastases","volume":"190","author":"Guckenberger","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0009","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1093\/neuonc\/noad225","article-title":"Stereotactic body radiation therapy for spinal metastases: A new standard of care","volume":"26","author":"Sacino","year":"2024","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109914","article-title":"Stereotactic body radiation therapy versus conventional external beam radiotherapy for spinal metastases: A systematic review and meta-analysis of randomized controlled trials","volume":"189","author":"Wong","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0011","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fonc.2019.00337","article-title":"Stereotactic body radiotherapy (SBRT) for Oligometastatic spine metastases: An overview","volume":"9","author":"Zeng","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0012","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.55409","article-title":"Stereotactic body and conventional radiotherapy for painful bone metastases: A systematic review and meta-analysis","volume":"7","author":"Bindels","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.adro.2025.101760_bib0013","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijrobp.2020.11.021","article-title":"Stereotactic body radiation therapy for spinal metastases: Tumor control probability analyses and recommended reporting standards","volume":"110","author":"Soltys","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101760_bib0014","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ijrobp.2022.09.076","article-title":"Dose-escalated 2-fraction spine stereotactic body radiation therapy: 28 Gy versus 24 Gy in 2 daily fractions","volume":"115","author":"Zeng","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101760_bib0015","doi-asserted-by":"crossref","first-page":"e597","DOI":"10.1016\/j.ijrobp.2012.03.009","article-title":"International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery","volume":"83","author":"Cox","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101760_bib0016","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2019.11.026","article-title":"International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT)","volume":"145","author":"Dunne","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0017","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijrobp.2019.09.038","article-title":"Spinal cord dose tolerance to stereotactic body radiation therapy","volume":"110","author":"Sahgal","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101760_bib0018","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.ijrobp.2015.03.037","article-title":"Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence","volume":"92","author":"Bishop","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101760_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110260","article-title":"Assessment of minimum target dose as a predictor of local failure after spine SBRT","volume":"195","author":"Kowalchuk","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0020","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A novel classification system for spinal instability in neoplastic disease: An evidence-based approach and expert consensus from the Spine Oncology Study Group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine"},{"key":"10.1016\/j.adro.2025.101760_bib0021","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3171\/2010.3.SPINE09459","article-title":"Reliability analysis of the epidural spinal cord compression scale","volume":"13","author":"Bilsky","year":"2010","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.adro.2025.101760_bib0022","doi-asserted-by":"crossref","first-page":"e595","DOI":"10.1016\/S1470-2045(15)00166-7","article-title":"Response assessment after stereotactic body radiotherapy for spinal metastasis: A report from the SPIne response assessment in Neuro-Oncology (SPINO) group","volume":"16","author":"Thibault","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0023","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.adro.2025.101760_bib0024","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.semradonc.2022.11.006","article-title":"Stereotactic body radiation therapy for spinal metastases: Benefits and limitations","volume":"33","author":"Guckenberger","year":"2023","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0025","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1016\/S1470-2045(13)70101-3","article-title":"Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases","volume":"14","author":"Sahgal","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0026","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/neuros\/nyx493","article-title":"Vertebral compression fracture after spine stereotactic body radiation therapy: A review of the pathophysiology and risk factors","volume":"83","author":"Faruqi","year":"2018","journal-title":"Neurosurgery"},{"key":"10.1016\/j.adro.2025.101760_bib0027","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jamaoncol.2021.7008","article-title":"Development and assessment of a predictive score for vertebral compression fracture after stereotactic body radiation therapy for spinal metastases","volume":"8","author":"Kowalchuk","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0028","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.prro.2022.08.010","article-title":"Safety and efficacy of dose-escalated radiation therapy with a simultaneous integrated boost for the treatment of spinal metastases","volume":"13","author":"Florez","year":"2023","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101760_bib0029","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2478\/raon-2022-0053","article-title":"Dose-escalated radiotherapy with simultaneous integrated boost for bone metastases in selected patients with assumed favourable prognosis","volume":"56","author":"Potkrajcic","year":"2022","journal-title":"Radiol Oncol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942500048X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942500048X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:23:17Z","timestamp":1762626197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245210942500048X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S245210942500048X"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101760","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase 2 Trial of Stereotactic Body Radiation Therapy with Dose Escalation Using Simultaneous Integrated Boost for Spinal Metastases","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101760"}}