{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:17:10Z","timestamp":1778890630665,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005081","name":"Beijing Council of Science and Technology","doi-asserted-by":"publisher","award":["KC2021-JX-0170-9"],"award-info":[{"award-number":["KC2021-JX-0170-9"]}],"id":[{"id":"10.13039\/501100005081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023ZD0502206"],"award-info":[{"award-number":["2023ZD0502206"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFC2404602"],"award-info":[{"award-number":["2022YFC2404602"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010098","name":"Shanghai Association for Science and Technology","doi-asserted-by":"publisher","award":["201409003000"],"award-info":[{"award-number":["201409003000"]}],"id":[{"id":"10.13039\/100010098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["23Y41900100"],"award-info":[{"award-number":["23Y41900100"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["22Y31900103"],"award-info":[{"award-number":["22Y31900103"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12023108"],"award-info":[{"award-number":["SHDC12023108"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752028"],"award-info":[{"award-number":["2024M752028"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009002","name":"Shanghai Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273278"],"award-info":[{"award-number":["82273278"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772654"],"award-info":[{"award-number":["81772654"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002630"],"award-info":[{"award-number":["82002630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373514"],"award-info":[{"award-number":["82373514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.adro.2025.101764","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T21:03:40Z","timestamp":1742331820000},"page":"101764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Active Microglia Alleviates Distal Edge of Proton Radiation-induced Neural Damage"],"prefix":"10.1016","volume":"10","author":[{"given":"Keman","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-5681","authenticated-orcid":false,"given":"Yingying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101764_bib0001","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1016\/S1470-2045(23)00184-5","article-title":"Global democratisation of proton radiotherapy","volume":"24","author":"Yan","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101764_bib0002","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ijrobp.2024.09.030","article-title":"Proton-based radiation therapy for skull base chondrosarcomas in children and adolescents: 40-year experience from the Massachusetts General Hospital","volume":"121","author":"Ioakeim-Ioannidou","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101764_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216268","article-title":"Particle radiotherapy in the era of radioimmunotherapy","volume":"567","author":"Zhou","year":"2023","journal-title":"Cancer Lett"},{"key":"10.1016\/j.adro.2025.101764_bib0004","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1158\/1078-0432.CCR-24-1215","article-title":"Decoding patient heterogeneity influencing radiation-induced brain necrosis","volume":"30","author":"Chamseddine","year":"2024","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.adro.2025.101764_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110421","article-title":"Secondary cancer risk in six anatomical sites when using PAT, IMPT, and VMAT\/IMRT radiotherapy","volume":"199","author":"Johnson","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101764_bib0006","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.radonc.2021.12.035","article-title":"Radiation induced contrast enhancement after proton beam therapy in patients with low grade glioma - how safe are protons?","volume":"167","author":"Harrabi","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101764_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2022.11.011","article-title":"Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients","volume":"178","author":"Eulitz","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101764_bib0008","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2020.03.012","article-title":"End-of-range radiobiological effect on rib fractures in patients receiving proton therapy for breast cancer","volume":"107","author":"Wang","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101764_bib0009","doi-asserted-by":"crossref","first-page":"8286","DOI":"10.3390\/ijms23158286","article-title":"Microglia as therapeutic target for radiation-induced brain injury","volume":"23","author":"Liu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.adro.2025.101764_bib0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12974-024-03198-1","article-title":"Repeated LPS induces training and tolerance of microglial responses across brain regions","volume":"21","author":"Kim","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.adro.2025.101764_bib0011","article-title":"Dynamic brain lipid profiles modulate microglial lipid droplet accumulation and inflammation under ischemic conditions in mice","volume":"11","author":"Wei","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.adro.2025.101764_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109698","article-title":"Asparagine endopeptidase deficiency mitigates radiation-induced brain injury by suppressing microglia-mediated neuronal senescence","volume":"27","author":"Qiu","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.adro.2025.101764_bib0013","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41386-023-01774-2","article-title":"Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice","volume":"49","author":"Qian","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.adro.2025.101764_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2023.102467","article-title":"Spinal cord injury-activated C\/EBP\u03b2-AEP axis mediates cognitive impairment through APP C586\/Tau N368 fragments spreading","volume":"227","author":"Wu","year":"2023","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.adro.2025.101764_bib0015","doi-asserted-by":"crossref","first-page":"17026","DOI":"10.1021\/acs.jmedchem.3c01804","article-title":"Discovery of orally available and brain penetrant AEP inhibitors","volume":"66","author":"Krummenacher","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.adro.2025.101764_bib0016","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1259\/0007-1285-62-740-679","article-title":"The linear-quadratic formula and progress in fractionated radiotherapy","volume":"62","author":"Fowler","year":"1989","journal-title":"Br J Radiol"},{"key":"10.1016\/j.adro.2025.101764_bib0017","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ijrobp.2022.02.020","article-title":"Neuroprotective effects of ultra-high dose rate FLASH Bragg peak proton irradiation","volume":"113","author":"Dokic","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101764_bib0018","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.ijrobp.2022.11.037","article-title":"Investigation of in-field and out-of-field radiation quality with microdosimetry and its impact on relative biological effectiveness in proton therapy","volume":"115","author":"Missiaggia","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101764_bib0019","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ijrobp.2016.09.042","article-title":"Proton treatment techniques for posterior fossa tumors: Consequences for linear energy transfer and dose-volume parameters for the brainstem and organs at risk","volume":"97","author":"Giantsoudi","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101764_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134987","article-title":"Molecular mechanism of Rolupram reducing neuroinflammation in noise induced tinnitus mice through TLR4\/NF kB\/NLRP3 protein\/caspase-1\/IL-1 \u03b2 signaling pathway","volume":"278","author":"Luo","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.adro.2025.101764_bib0021","article-title":"Microglia in radiation-induced brain injury: Cellular and molecular mechanisms and therapeutic potential","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.adro.2025.101764_bib0022","first-page":"300","article-title":"Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat","volume":"23","author":"Xu","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.adro.2025.101764_bib0023","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neuron.2022.12.009","article-title":"Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes","volume":"111","author":"Shi","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.adro.2025.101764_bib0024","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.it.2024.08.004","article-title":"Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine","volume":"45","author":"Summers","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.adro.2025.101764_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110117","article-title":"Proton therapy induces a local microglial neuroimmune response","volume":"193","author":"Voshart","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101764_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107699","article-title":"Radiation triggers a dynamic sequence of transient microglial alterations in juvenile brain","volume":"31","author":"Osman","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.adro.2025.101764_bib0027","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41408-024-01139-y","article-title":"Bispecific antibodies in the treatment of multiple myeloma","volume":"14","author":"Devasia","year":"2024","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.adro.2025.101764_bib0028","doi-asserted-by":"crossref","first-page":"8949","DOI":"10.3390\/ijms25168949","article-title":"Different strategies to overcome resistance to proteasome inhibitors-a summary 20 years after their introduction","volume":"25","author":"Tyrna","year":"2024","journal-title":"Int J Mol Sci"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:11Z","timestamp":1778889611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109425000521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2452109425000521"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101764","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting Active Microglia Alleviates Distal Edge of Proton Radiation-induced Neural Damage","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101764"}}