{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:41:22Z","timestamp":1792716082880,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.adro.2025.101802","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:32:21Z","timestamp":1745926341000},"page":"101802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study"],"prefix":"10.1016","volume":"10","author":[{"given":"Giuseppe","family":"Cardaci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Baxi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-0940","authenticated-orcid":false,"given":"Cody","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Mulholland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Sathekge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kgomotso","family":"Mokoala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Heuschkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Tietze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siroos","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Dahlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101802_bib0001","article-title":"The incidence and clinical analysis of non-melanoma skin cancer","volume":"11","author":"Ci\u0105\u017cy\u0144ska","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.adro.2025.101802_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108226","volume":"181","author":"Pega","year":"2023","journal-title":"Environ Int"},{"key":"10.1016\/j.adro.2025.101802_bib0003","author":"Organization","year":"2017","journal-title":"Radiation: Ultraviolet (UV) radiation and skin cancer"},{"key":"10.1016\/j.adro.2025.101802_bib0004","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3390\/diagnostics13040793","article-title":"Management of non-melanoma skin cancer: radiologists challenging and risk assessment","volume":"13","author":"Russo","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.adro.2025.101802_bib0005","doi-asserted-by":"crossref","DOI":"10.17061\/phrp3212203","article-title":"Keratinocyte cancer incidence in Australia: A review of population-based incidence trends and estimates of lifetime risk","volume":"32","author":"Olsen","year":"2022","journal-title":"Public Health Res. Pract"},{"key":"10.1016\/j.adro.2025.101802_bib0006","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1186\/s12885-022-09940-3","article-title":"Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25\u2009years","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.adro.2025.101802_bib0007","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/MOO.0000000000000960","article-title":"Head and neck nonmelanoma skin cancers: Surgical management and debated issues","volume":"32","author":"Rampinelli","year":"2024","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.adro.2025.101802_bib0008","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/ajd.12205","article-title":"Quality of life in non-melanoma skin cancer","volume":"56","author":"Gaulin","year":"2015","journal-title":"Australas J Dermatol"},{"key":"10.1016\/j.adro.2025.101802_bib0009","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jamadermatol.2014.3307","article-title":"Timing of subsequent new tumors in patients who present with basal cell carcinoma or cutaneous squamous cell carcinoma","volume":"151","author":"Wehner","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.adro.2025.101802_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012622","article-title":"The use of retinoids for the prevention and treatment of skin cancers: An updated review","volume":"23","author":"Ramchatesingh","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.adro.2025.101802_bib0011","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3390\/cancers15092408","article-title":"The role of radiation therapy in the treatment of non-melanoma skin cancer","volume":"15","author":"Yosefof","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.adro.2025.101802_bib0012","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/healthcare5040082","article-title":"Updates on the management of non-melanoma skin cancer (NMSC)","volume":"5","author":"Fahradyan","year":"2017","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.adro.2025.101802_bib0013","doi-asserted-by":"crossref","first-page":"f6153","DOI":"10.1136\/bmj.f6153","article-title":"Interventions for non-metastatic squamous cell carcinoma of the skin: Systematic review and pooled analysis of observational studies","volume":"347","author":"Lansbury","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.adro.2025.101802_bib0014","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00259-020-05088-z","article-title":"High dose brachytherapy with non sealed 188Re (rhenium) resin in patients with non-melanoma skin cancers (NMSCs): Single center preliminary results","volume":"48","author":"Castellucci","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.adro.2025.101802_bib0015","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/09546634.2020.1793890","article-title":"Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: A long-term retrospective study","volume":"33","author":"Cipriani","year":"2022","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.adro.2025.101802_bib0016","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/RLU.0000000000004824","article-title":"Topical 188Re ionizing radiation therapy exerts high efficacy in curing nonmelanoma skin cancer","volume":"48","author":"Tietze","year":"2023","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.adro.2025.101802_bib0017","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1365-2230.2008.02852.x","article-title":"Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma","volume":"33","author":"Sedda","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.adro.2025.101802_bib0018","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.2967\/jnumed.124.267988","article-title":"Effectiveness and patient experiences of rhenium skin cancer therapy for nonmelanoma skin cancer: Interim results from the EPIC-skin study","volume":"65","author":"Baxi","year":"2024","journal-title":"J Nucl Med"},{"key":"10.1016\/j.adro.2025.101802_bib0019","unstructured":"Hamby DM, Mangini CD, Caffrey JA, Tang M. VARSKIN 5: A Computer Code for Skin Contamination Dosimetry. 2014, Retrieved December 18, 2024. (NUREG\/CR-6918, Rev. 2.)."},{"key":"10.1016\/j.adro.2025.101802_bib0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2025.101802_bib0021","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/MLG.0b013e31802e2d88","article-title":"The skin cancer index: Clinical responsiveness and predictors of quality of life","volume":"117","author":"Rhee","year":"2007","journal-title":"Laryngoscope"},{"key":"10.1016\/j.adro.2025.101802_bib0022","unstructured":"National Cancer Institute. Common terminology criteria for adverse events (CTCAE) version 5.0; 2017.https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf#:\u223c:text=Grade%20refers%20to%20the%20severity%20of%20the%20AE.,clinical%20or%20diagnostic%20observations%20only%3B%20intervention%20not%20indicated."},{"key":"10.1016\/j.adro.2025.101802_bib0023","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2025.101802_bib0024","first-page":"65","article-title":"The International Conference on Harmonization Good Clinical Practice guideline","volume":"6","author":"Dixon","year":"1998","journal-title":"Qual Assur San Diego Calif"},{"issue":"suppl 3","key":"10.1016\/j.adro.2025.101802_bib0025","first-page":"S45","article-title":"Surgical treatment of nonmelanoma skin cancer in older adult veterans","volume":"39","author":"Coady-Fariborzian","year":"2022","journal-title":"Fed Pract"},{"key":"10.1016\/j.adro.2025.101802_bib0026","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11864-021-00826-3","article-title":"Neoadjuvant therapy for non-melanoma skin cancer: Updated therapeutic approaches for basal, squamous, and Merkel cell carcinoma","volume":"22","author":"Zelin","year":"2021","journal-title":"Curr TreatOptions Oncol"},{"key":"10.1016\/j.adro.2025.101802_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005082","article-title":"Update in the treatment of non-melanoma skin cancers: The use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma","volume":"10","author":"Ascierto","year":"2022","journal-title":"J Immunother Cancer"},{"issue":"5","key":"10.1016\/j.adro.2025.101802_bib0028","doi-asserted-by":"crossref","DOI":"10.1111\/dth.12515","article-title":"Noninvasive treatment of keloid using customized Re-188 skin patch","volume":"30","author":"Bhusari","year":"2017","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.adro.2025.101802_bib0029","first-page":"115","article-title":"Dermo beta brachytherapy with 188Re in extramammary Paget\u2019s disease","volume":"149","author":"Carrozzo","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1016\/j.adro.2025.101802_bib0030","first-page":"9560","article-title":"Cutaneous squamous cell carcinoma of the lip successfully treated with rhenium-188 brachytherapy","volume":"15","author":"Sabbadini","year":"2023","journal-title":"Dermatol Rep"},{"key":"10.1016\/j.adro.2025.101802_bib0031","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3390\/healthcare12090921","article-title":"Patient-orientated evaluation of treatment of non-melanoma skin cancer with rhenium-188 compared to surgery","volume":"12","author":"Kr\u00f6nert","year":"2024","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.adro.2025.101802_bib0032","doi-asserted-by":"crossref","first-page":"533","DOI":"10.5114\/jcb.2016.64112","article-title":"Non-melanoma skin cancer treated with high-dose-rate brachytherapy: A review of literature","volume":"8","author":"Delishaj","year":"2016","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.adro.2025.101802_bib0033","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jaad.2005.07.045","article-title":"Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas","volume":"53","author":"Schulte","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.adro.2025.101802_bib0034","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2017.77.0941","article-title":"Postoperative concurrent chemoradiotherapy versus postoperative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: The randomized phase III TROG 05.01 trial","volume":"36","author":"Porceddu","year":"2018","journal-title":"J Clin Oncol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425000892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:23:16Z","timestamp":1762626196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109425000892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2452109425000892"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101802","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy, Safety, and Patient Reported Outcomes of Rhenium-Skin Cancer Therapy for Non-Melanoma Skin Cancer: 1-Year Results from the EPIC-Skin Study","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101802"}}