{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:20:46Z","timestamp":1774448446372,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.adro.2025.101948","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:21:36Z","timestamp":1763184096000},"page":"101948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Outcomes and Institutional Experience of Ultrahypofractionated Radiation Therapy in Patients With Breast Cancer"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8156-7889","authenticated-orcid":false,"suffix":"MD, FRCPC","given":"Hiba","family":"Othman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Aisling","family":"Barry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Anthony","family":"Fyles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Rodin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Ezra","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Fei-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Joelle","family":"Helou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Glicksman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, FRCPC","given":"Naghmeh","family":"Isfahanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Baskurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"PhD, MCCPM","given":"Tom","family":"Purdie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-6313","authenticated-orcid":false,"given":"Jennifer","family":"Croke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101948_bib0001","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/jnci\/88.22.1659","article-title":"Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: An update","volume":"88","author":"Clark","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2025.101948_bib0002","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer","volume":"347","author":"Fisher","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2025.101948_bib0003","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10 801 women in 17 randomised trials","volume":"378","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101948_bib0004","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1056\/NEJM199306033282202","article-title":"Radiotherapy after breast-preserving surgery in women with localized cancer of the breast","volume":"328","author":"Veronesi","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2025.101948_bib0005","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"371","author":"Bentzen","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101948_bib0006","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1245\/s10434-012-2546-5","article-title":"Cost comparison of radiation treatment options after lumpectomy for breast Cancer","volume":"19","author":"Greenup","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0007","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0008","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Murray Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101948_bib0009","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/94.15.1143","article-title":"Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer","volume":"94","author":"Whelan","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2025.101948_bib0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2025.101948_bib0011","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.clon.2022.02.009","article-title":"How low can you go? The radiobiology of hypofractionation","volume":"34","author":"Brand","year":"2022","journal-title":"Clin Oncol. (R Coll Radiol)"},{"key":"10.1016\/j.adro.2025.101948_bib0012","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1001\/jama.2014.16616","article-title":"Uptake and costs of hypofractionated vs conventional whole breast irradiation after breast conserving surgery in the United States, 2008\u20132013","volume":"312","author":"Bekelman","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2025.101948_bib0013","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/curroncol28010070","article-title":"Cost minimization analysis of hypofractionated radiotherapy","volume":"28","author":"Yaremko","year":"2021","journal-title":"Curr Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0014","series-title":"The Canadian Experience with Hypofractionation","first-page":"169","author":"Arsenault","year":"2016"},{"key":"10.1016\/j.adro.2025.101948_bib0015","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.radonc.2016.08.027","article-title":"Prolongation of overall treatment time as a cause of treatment failure in early breast cancer: An analysis of the UK START (Standardisation of Breast Radiotherapy) trials of radiotherapy fractionation","volume":"121","author":"Haviland","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0016","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-05-0321","article-title":"Translating research into clinical practice: Deliberations from the American Association for Cancer Research","volume":"11","author":"Hait","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.adro.2025.101948_bib0017","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.prro.2018.01.012","article-title":"Radiation therapy for the whole breast: Executive summary of an American Society for Radiation Oncology (ASTRO) evidence-based guideline","volume":"8","author":"Smith","year":"2018","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0018","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2004.04.059","article-title":"Long-term results of adjuvant hypofractionated radiotherapy for breast cancer in elderly patients","volume":"61","author":"Ortholan","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101948_bib0019","article-title":"Adoption of ultrahypofractionated radiation therapy in patients with breast cancer","volume":"7","author":"Corrigan","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0020","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.adro.2020.06.002","article-title":"Rapid adaptation of breast radiation therapy use during the coronavirus disease 2019 pandemic at a large academic cancer center in Canada","volume":"5","author":"Koch","year":"2020","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0021","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ijrobp.2014.06.056","article-title":"Automation and intensity modulated radiation therapy for individualized high-quality tangent breast treatment plans","volume":"90","author":"Purdie","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101948_bib0022","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/01621459.2016.1260466","article-title":"Balancing covariates via propensity score weighting","volume":"113","author":"Li","year":"2018","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.adro.2025.101948_bib0023","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1001\/jama.2020.7819","article-title":"Overlap weighting: A propensity score method that mimics attributes of a randomized clinical trial","volume":"323","author":"Thomas","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2025.101948_bib0024","unstructured":"Team RC. A language and environment for statistical computing. Vienna, Austria, 2023. Accessed August 21, 2025; https:\/\/www.R-project.org\/."},{"key":"10.1016\/j.adro.2025.101948_bib0025","unstructured":"Greifer N. WeightIt: Weighting for covariate balance in observational studies; 2024. Accessed August 21, 2025; https:\/\/CRAN.R-project.org\/package=WeightIt."},{"key":"10.1016\/j.adro.2025.101948_bib0026","unstructured":"Greifer N. Cobalt: Covariate balance tables and plots 2024. Accessed August 21, 2025; https:\/\/CRAN.R-project.org\/package=cobalt."},{"key":"10.1016\/j.adro.2025.101948_bib0027","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.breast.2022.12.008","article-title":"Implementation of 26 Gy in five fractions over 1 week adjuvant radiotherapy for breast cancer: Prospective report of acute skin toxicity and consideration of resource implications","volume":"67","author":"Nugent","year":"2023","journal-title":"Breast"},{"key":"10.1016\/j.adro.2025.101948_bib0028","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.3390\/biomedicines10102568","article-title":"Ultra-hypofractionation for whole-breast irradiation in early breast cancer: Interim analysis of a prospective study","volume":"10","author":"Sigaudi","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.adro.2025.101948_bib0029","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3390\/medicina58060745","article-title":"Ultra-hypofractionated vs. moderate fractionated whole breast three dimensional conformal radiotherapy during the COVID-19 pandemic","volume":"58","author":"Ivanov","year":"2022","journal-title":"Medicina"},{"key":"10.1016\/j.adro.2025.101948_bib0030","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2016.02.027","article-title":"Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial","volume":"120","author":"Brunt","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0031","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.radonc.2020.07.038","article-title":"Variation in the use of radiotherapy fractionation for breast cancer: Survival outcome and cost implications","volume":"152","author":"Batumalai","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101948_bib0032","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.clon.2020.03.006","article-title":"International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic","volume":"32","author":"Coles","year":"2020","journal-title":"Clin Oncol. (R Coll Radiol)."},{"key":"10.1016\/j.adro.2025.101948_bib0033","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0140-6736(22)01246-6","article-title":"Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3\u201307\/TROG 07.01): A randomised, factorial, multicentre, open-label, phase 3 study","volume":"400","author":"Chua","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101948_bib0034","first-page":"134","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) 92-04","volume":"31","author":"Jd","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425002350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425002350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:23:13Z","timestamp":1770981793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109425002350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2452109425002350"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101948","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Outcomes and Institutional Experience of Ultrahypofractionated Radiation Therapy in Patients With Breast Cancer","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101948"}}