{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:13:03Z","timestamp":1770984783942,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.adro.2025.101966","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:16:24Z","timestamp":1763828184000},"page":"101966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogel Spacer Insertion Prior to Stereotactic Body Radiation Therapy to the Prostate: A Comparative Study"],"prefix":"10.1016","volume":"11","author":[{"given":"Myroslav","family":"Lutsyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosef","family":"Landman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-3189","authenticated-orcid":false,"given":"Eyal","family":"Fenig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101966_bib0001","doi-asserted-by":"crossref","DOI":"10.1177\/1557988320927241","article-title":"Stereotactic body radiotherapy for prostate cancer","volume":"14","author":"Parikh","year":"2020","journal-title":"Am J Mens Health"},{"key":"10.1016\/j.adro.2025.101966_bib0002","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.radonc.2016.10.013","article-title":"Patient-reported quality of life after stereotactic body radiation therapy versus moderate hypofractionation for clinically localized prostate cancer","volume":"121","author":"Johnson","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0003","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijrobp.2018.05.040","article-title":"Multicenter trial of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer: Survival and toxicity endpoints","volume":"102","author":"Meier","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101966_bib0004","unstructured":"US Food and Drug Administration. Letter to Noel Rolon. 2015. Accessed December 2, 2020.https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf14\/DEN140030.pdf"},{"key":"10.1016\/j.adro.2025.101966_bib0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijrobp.2015.04.030","article-title":"Hydrogel spacer prospective multicenter randomized controlled pivotal trial: Dosimetric and clinical effects of perirectal spacer application in men undergoing prostate image guided intensity modulated radiation therapy","volume":"92","author":"Mariados","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101966_bib0006","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijrobp.2016.12.024","article-title":"Continued benefit to rectal separation for prostate radiation therapy: Final results of a phase III trial","volume":"97","author":"Hamstra","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2025.101966_bib0007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1470-2045(20)30639-2","article-title":"Considering benefit and risk before routinely recommending SpaceOAR","volume":"22","author":"Hall","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0008","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0140-6736(19)31131-6","article-title":"Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial","volume":"394","author":"Widmark","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101966_bib0009","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S1470-2045(19)30569-8","article-title":"Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): Acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial","volume":"20","author":"Brand","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13014-021-01834-1","article-title":"Phase II study of stereotactic body radiotherapy with hydrogel spacer for prostate cancer: Acute toxicity and propensity score-matched comparison","volume":"16","author":"Ogita","year":"2021","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0011","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.euo.2019.09.006","article-title":"Early tolerance and tumor control outcomes with high-dose ultrahypofractionated radiation therapy for prostate cancer","volume":"3","author":"Zelefsky","year":"2020","journal-title":"Eur Urol Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0012","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.urology.2023.09.016","article-title":"Real-world complications of the SpaceOAR hydrogel spacer: A review of the manufacturer and user facility device experience database","volume":"183","author":"Fernandez","year":"2024","journal-title":"Urology"},{"key":"10.1016\/j.adro.2025.101966_bib0013","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1089\/end.2019.0431","article-title":"Major complications and adverse events related to the injection of the SpaceOAR hydrogel system before radiotherapy for prostate cancer: Review of the manufacturer and user facility device experience database","volume":"33","author":"Aminsharifi","year":"2019","journal-title":"J Endourol"},{"key":"10.1016\/j.adro.2025.101966_bib0014","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2217\/fon-2017-0073","article-title":"Hydrogel spacers in prostate radiotherapy: A promising approach to decrease rectal toxicity","volume":"13","author":"Padmanabhan","year":"2017","journal-title":"Future Oncol"},{"key":"10.1016\/j.adro.2025.101966_bib0015","series-title":"Hydrogel Spacers for Patients With Prostate Cancer: A Review of Clinical Effectiveness and Cost-Effectiveness","author":"Chao","year":"2019"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425002532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109425002532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:23:47Z","timestamp":1770981827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109425002532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2452109425002532"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101966","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogel Spacer Insertion Prior to Stereotactic Body Radiation Therapy to the Prostate: A Comparative Study","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101966","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Rabin Medical Center. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101966"}}