{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:26:18Z","timestamp":1777901178193,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22zf0127008"],"award-info":[{"award-number":["JP22zf0127008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23zf0127008"],"award-info":[{"award-number":["JP23zf0127008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018326","name":"Suntory Foundation for Life Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03596"],"award-info":[{"award-number":["JP21H03596"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008608","name":"Sumitomo Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007533","name":"Kobayashi Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001009","name":"Bristol-Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.adro.2025.101987","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T16:07:48Z","timestamp":1766678868000},"page":"101987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Esophageal Cancer Cells Exhibit Heterogeneity in DNA Double-Strand Break Repair and G2\/M Checkpoint Arrest Associated With Cell Viability After Ionizing Radiation"],"prefix":"10.1016","volume":"11","author":[{"given":"Kohei","family":"Tateno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Haruna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Isono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Yokobori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2025.101987_bib0001","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0140-6736(24)02226-8","article-title":"Oesophageal cancer","volume":"404","author":"Yang","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101987_bib0002","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.3748\/wjg.v19.i34.5598","article-title":"Epidemiology of esophageal cancer","volume":"19","author":"Zhang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.adro.2025.101987_bib0003","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41416-021-01485-9","article-title":"Advances in the curative management of oesophageal cancer","volume":"126","author":"Bolger","year":"2022","journal-title":"Br J Cancer"},{"key":"10.1016\/j.adro.2025.101987_bib0004","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.apsb.2021.03.008","article-title":"Advances and challenges in the treatment of esophageal cancer","volume":"11","author":"He","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.adro.2025.101987_bib0005","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/cac2.12457","article-title":"Worldwide trends in esophageal cancer survival, by sub-site, morphology, and sex: An analysis of 696,974 adults diagnosed in 60 countries during 2000-2014 (CONCORD-3)","volume":"43","author":"Matz","year":"2023","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.adro.2025.101987_bib0006","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41392-021-00648-7","article-title":"DNA damage repair: Historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.adro.2025.101987_bib0007","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1056\/NEJMoa2111380","article-title":"Nivolumab combination therapy in advanced esophageal squamous-cell carcinoma","volume":"386","author":"Doki","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2025.101987_bib0008","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(21)01234-4","article-title":"Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): A randomised, placebo-controlled, phase 3 study","volume":"398","author":"Sun","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2025.101987_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103466","article-title":"Biomarkers for the prediction of esophageal cancer neoadjuvant chemoradiotherapy response: A systemic review","volume":"167","author":"Li","year":"2021","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.adro.2025.101987_bib0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.adro.2025.101987_bib0011","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.3390\/cancers14061522","article-title":"Toward targeted therapies in oesophageal cancers: An overview","volume":"14","author":"Bregni","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.adro.2025.101987_bib0012","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clon.2013.06.007","article-title":"Biological consequences of radiation-induced DNA damage: Relevance to radiotherapy","volume":"25","author":"Lomax","year":"2013","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.adro.2025.101987_bib0013","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13073-025-01488-8","article-title":"DNA repair and the contribution to chemotherapy resistance","volume":"17","author":"Nesic","year":"2025","journal-title":"Genome Med"},{"key":"10.1016\/j.adro.2025.101987_bib0014","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1158\/2159-8290.CD-12-0189","article-title":"Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma","volume":"2","author":"Agrawal","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.adro.2025.101987_bib0015","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/cdd.2017.169","article-title":"How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.adro.2025.101987_bib0016","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/s41467-017-01883-9","article-title":"DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells","volume":"8","author":"Sato","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.adro.2025.101987_bib0017","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1038\/s41388-019-0733-6","article-title":"Base excision repair regulates PD-L1 expression in cancer cells","volume":"38","author":"Permata","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.adro.2025.101987_bib0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tox.2005.04.015","article-title":"Cisplatin-mediated DNA double-strand breaks in replicating but not in quiescent cells of the yeast Saccharomyces cerevisiae","volume":"212","author":"Frankenberg-Schwager","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.adro.2025.101987_bib0019","first-page":"51","article-title":"Regulation of repair pathway choice at two-ended DNA double-strand breaks","volume":"803-805","author":"Shibata","year":"2017","journal-title":"Mutat Res"},{"key":"10.1016\/j.adro.2025.101987_bib0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.clon.2014.02.004","article-title":"DNA double-strand break repair in a cellular context","volume":"26","author":"Shibata","year":"2014","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.adro.2025.101987_bib0021","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/emboj.2011.27","article-title":"Factors determining DNA double-strand break repair pathway choice in G2 phase","volume":"30","author":"Shibata","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.adro.2025.101987_bib0022","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2013.11.003","article-title":"DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities","volume":"53","author":"Shibata","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.adro.2025.101987_bib0023","doi-asserted-by":"crossref","first-page":"10298","DOI":"10.1093\/nar\/gkt802","article-title":"Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection","volume":"41","author":"Kakarougkas","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.adro.2025.101987_bib0024","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.celrep.2016.12.042","article-title":"BRCA1 directs the repair pathway to homologous recombination by promoting 53BP1 dephosphorylation","volume":"18","author":"Isono","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.adro.2025.101987_bib0025","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nature09399","article-title":"Purified human BRCA2 stimulates RAD51-mediated recombination","volume":"467","author":"Jensen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.adro.2025.101987_bib0026","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nature03404","article-title":"CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair","volume":"434","author":"Esashi","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.adro.2025.101987_bib0027","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nrm2851","article-title":"Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis","volume":"11","author":"Moynahan","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.adro.2025.101987_bib0028","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.biochem.77.061306.125255","article-title":"Mechanism of eukaryotic homologous recombination","volume":"77","author":"San Filippo","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.adro.2025.101987_bib0029","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3390\/genes12091370","article-title":"ATM's role in the repair of DNA double-strand breaks","volume":"12","author":"Shibata","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.adro.2025.101987_bib0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ncb1337","article-title":"ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks","volume":"8","author":"Jazayeri","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.adro.2025.101987_bib0031","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/MCB.01644-09","article-title":"Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)\/M checkpoint arrest","volume":"30","author":"Shibata","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.adro.2025.101987_bib0032","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: The trinity at the heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.adro.2025.101987_bib0033","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/erm.2020.3","article-title":"DNA damage checkpoint kinases in cancer","volume":"22","author":"Smith","year":"2020","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.adro.2025.101987_bib0034","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C","article-title":"Characterization of 21 newly established esophageal cancer cell lines","volume":"69","author":"Shimada","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2025.101987_bib0035","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4161\/cc.9.4.10764","article-title":"gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization","volume":"9","author":"L\u00f6brich","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.adro.2025.101987_bib0036","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.asr.2008.10.011","article-title":"\u03b3-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin","volume":"43","author":"Redon","year":"2009","journal-title":"Adv Space Res"},{"key":"10.1016\/j.adro.2025.101987_bib0037","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.adro.2025.101987_bib0038","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.adro.2025.101987_bib0039","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.adro.2025.101987_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11428","article-title":"A genetic basis for the variation in the vulnerability of cancer to DNA damage","volume":"7","author":"Yard","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.adro.2025.101987_bib0041","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.adro.2025.101987_bib0042","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1038\/emboj.2009.276","article-title":"ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2","volume":"28","author":"Beucher","year":"2009","journal-title":"Embo J"},{"key":"10.1016\/j.adro.2025.101987_bib0043","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10409238.2011.575764","article-title":"Understanding the limitations of radiation-induced cell cycle checkpoints","volume":"46","author":"Deckbar","year":"2011","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.adro.2025.101987_bib0044","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115121","article-title":"Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe","volume":"9","author":"Amornwichet","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.adro.2025.101987_bib0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41392-020-00323-3","article-title":"Advances in targeted therapy for esophageal cancer","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.adro.2025.101987_bib0046","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/2159-8290.CD-16-0860","article-title":"Targeting DNA repair in cancer: beyond PARP inhibitors","volume":"7","author":"Brown","year":"2017","journal-title":"Cancer Discov"},{"key":"10.1016\/j.adro.2025.101987_bib0047","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","article-title":"Targeting DNA damage response pathways in cancer","volume":"23","author":"Groelly","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.adro.2025.101987_bib0048","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/SLA.0000000000003975","article-title":"RAD51 expression as a biomarker to predict efficacy of preoperative therapy and survival for esophageal squamous cell carcinoma: A large-cohort observational study (KSCC1307)","volume":"275","author":"Saeki","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.adro.2025.101987_bib0049","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/ijc.35310","article-title":"Exploration of histone protein \u03b3-H2AX as a prognostic factor in soft tissue sarcomas and its association with biological behavior, immune cell environment and survival in leiomyosarcoma","volume":"156","author":"Simon","year":"2024","journal-title":"Int J Cancer"},{"key":"10.1016\/j.adro.2025.101987_bib0050","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1158\/1078-0432.CCR-22-3335","article-title":"RAD51 foci as a biomarker predictive of platinum chemotherapy response in ovarian cancer","volume":"29","author":"Compadre","year":"2023","journal-title":"Clin Cancer Res"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942500274X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942500274X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:53:58Z","timestamp":1777632838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245210942500274X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S245210942500274X"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2025.101987","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Esophageal Cancer Cells Exhibit Heterogeneity in DNA Double-Strand Break Repair and G2\/M Checkpoint Arrest Associated With Cell Viability After Ionizing Radiation","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2025.101987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101987"}}