{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:16:54Z","timestamp":1778890614697,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007322","name":"Fox Chase Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009395","name":"CancerCare Manitoba Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008275","name":"University of Florida Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006710","name":"Wayne State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030675","name":"Loyola Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008891","name":"Loma Linda University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017302","name":"Barbara Ann Karmanos Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG1CA189867"],"award-info":[{"award-number":["UG1CA189867"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Z99 CA999999"],"award-info":[{"award-number":["Z99 CA999999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020768","name":"University of Utah Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020768","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018047","name":"NRG Oncology Foundation Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017062","name":"Johns Hopkins Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008980","name":"Medical College of Wisconsin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015770","name":"Greenville Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.adro.2026.102022","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:17:33Z","timestamp":1773159453000},"page":"102022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of p27 With Prostate Cancer Outcomes: A Secondary Analysis of NRG\/RTOG 8610 and 9202"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2120-1939","authenticated-orcid":false,"given":"Krishnan R.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Pugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffry P.","family":"Simko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Zietman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelangelo","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Paul","family":"D\u2019Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Currey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Dicker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley J.","family":"Stish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric M.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler P.","family":"Robin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dominello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Efstathiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Daniel","family":"Grass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaker H.","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phuoc T.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Loda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2026.102022_bib0001","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1200\/JCO.2014.55.1192","article-title":"Long-term follow-up of a large active surveillance cohort of patients with prostate cancer","volume":"33","author":"Klotz","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0002","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa1011967","article-title":"Radical prostatectomy versus watchful waiting in early prostate cancer","volume":"364","author":"Bill-Axelson","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2026.102022_bib0003","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/jama.299.3.289","article-title":"Androgen suppression and radiation vs radiation alone for prostate cancer: a randomized trial","volume":"299","author":"D\u2019Amico","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2026.102022_bib0004","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1012348","article-title":"Radiotherapy and short-term androgen deprivation for localized prostate cancer","volume":"365","author":"Jones","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2026.102022_bib0005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(21)02437-5","article-title":"Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol","volume":"399","author":"Attard","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2026.102022_bib0006","series-title":"AJCC cancer staging manual","author":"Amin","year":"2017"},{"key":"10.1016\/j.adro.2026.102022_bib0007","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1200\/JCO.2002.03.061","article-title":"Determinants of prostate cancer-specific survival after radiation therapy for patients with clinically localized prostate cancer","volume":"20","author":"D'Amico","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0008","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1200\/JCO.2017.74.2940","article-title":"Development and validation of a novel integrated clinical-genomic risk group classification for localized prostate cancer","volume":"36","author":"Spratt","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0009","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41746-022-00613-w","article-title":"Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials","volume":"5","author":"Esteva","year":"2022","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.adro.2026.102022_bib0010","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1002\/cncr.34790","article-title":"A novel prostate cancer subtyping classifier based on luminal and basal phenotypes","volume":"129","author":"Weiner","year":"2023","journal-title":"Cancer"},{"key":"10.1016\/j.adro.2026.102022_bib0011","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1470-2045(10)70295-3","article-title":"Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study","volume":"12","author":"Cuzick","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0012","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00432-022-04135-6","article-title":"Cyclins and cyclin-dependent kinases: from biology to tumorigenesis and therapeutic opportunities","volume":"149","author":"Zabihi","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0013","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/mend.15.5.0640","article-title":"Androgen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27","volume":"15","author":"Waltregny","year":"2001","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.adro.2026.102022_bib0014","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2011.06.033","article-title":"The AR-dependent cell cycle: mechanisms and cancer relevance","volume":"352","author":"Schiewer","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.adro.2026.102022_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162806","article-title":"p27Kip1 is required to mediate a G1 cell cycle arrest downstream of ATM following genotoxic stress","volume":"11","author":"Cassimere","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.adro.2026.102022_bib0016","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/emboj\/18.6.1571","article-title":"The p21(Cip1) and p27(Kip1) CDK \u2018inhibitors\u2019 are essential activators of cyclin D-dependent kinases in murine fibroblasts","volume":"18","author":"Cheng","year":"1999","journal-title":"Embo J"},{"key":"10.1016\/j.adro.2026.102022_bib0017","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1083\/jcb.153.5.917","article-title":"Cyclin-dependent kinase inhibitor P27Kip1 is required for mouse mammary gland morphogenesis and function","volume":"153","author":"Muraoka","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1016\/j.adro.2026.102022_bib0018","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0022-5347(01)63776-5","article-title":"Low p27 expression predicts poor disease-free survival in patients with prostate cancer","volume":"159","author":"Yang","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.adro.2026.102022_bib0019","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/01.ju.0000054004.08958.f3","article-title":"Preoperative p27 status is an independent predictor of prostate-specific antigen failure following radical prostatectomy","volume":"169","author":"Freedland","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.adro.2026.102022_bib0020","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/jnci\/90.12.916","article-title":"Association of p27Kipl levels with recurrence and survival in patients with stage C prostate carcinoma","volume":"90","author":"Cote","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.adro.2026.102022_bib0021","first-page":"542","article-title":"Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma","volume":"58","author":"Tsihlias","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.adro.2026.102022_bib0022","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1200\/JCO.2007.13.9881","article-title":"Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: long-term results of RTOG 8610","volume":"26","author":"Roach","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0023","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1200\/JCO.2003.11.023","article-title":"Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: the Radiation Therapy Oncology Group Protocol 92-02","volume":"21","author":"Hanks","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0024","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2006.04.029","article-title":"Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference","volume":"65","author":"Roach","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102022_bib0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.adro.2026.102022_bib0026","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/pros.24036","article-title":"miR-196a-mediated downregulation of p27kip1 protein promotes prostate cancer proliferation and relates to biochemical recurrence after radical prostatectomy","volume":"80","author":"Zhan","year":"2020","journal-title":"Prostate"},{"key":"10.1016\/j.adro.2026.102022_bib0027","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0022-5347(05)00151-5","article-title":"Biological correlates of p27 compartmental expression in prostate cancer","volume":"175","author":"Li","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.adro.2026.102022_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-5751-11-2","article-title":"Lack of prognostic significance of p16 and p27 after radical prostatectomy in hormone-na\u00efve prostate cancer","volume":"11","author":"Vlachostergios","year":"2012","journal-title":"J Negative Results Biomed"},{"key":"10.1016\/j.adro.2026.102022_bib0029","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1158\/0008-5472.CAN-19-3663","article-title":"p27 as a transcriptional regulator: new roles in development and cancer","volume":"80","author":"Razavipour","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.adro.2026.102022_bib0030","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3892\/ol.2015.3726","article-title":"p27Kip1 expression as a prognostic marker for squamous cell carcinoma of the head and neck","volume":"10","author":"De Almeida","year":"2015","journal-title":"Oncology Lett"},{"key":"10.1016\/j.adro.2026.102022_bib0031","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4048\/jbc.2024.0107","article-title":"p27 cell cycle inhibitor and survival in luminal-type breast cancer: gene ontology, machine learning, and drug screening analysis","volume":"27","author":"Park","year":"2024","journal-title":"J Breast Cancer"},{"key":"10.1016\/j.adro.2026.102022_bib0032","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc2347","article-title":"The CDK inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy","volume":"8","author":"Chu","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.adro.2026.102022_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144351","article-title":"The clinicopathological and prognostic significance of P27kip in hepatocellular carcinoma patients: a systemic review and meta-analysis","volume":"734","author":"Luo","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.adro.2026.102022_bib0034","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nm0297-231","article-title":"Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas","volume":"3","author":"Loda","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.adro.2026.102022_bib0035","article-title":"Prognostic value of an immunohistochemical signature in patients with bladder cancer undergoing radical cystectomy","volume":"11","author":"Wu","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.adro.2026.102022_bib0036","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.21873\/anticanres.11245","article-title":"Cyclins A, B, E and p27 in endometrial endometrioid adenocarcinoma","volume":"36","author":"Santala","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1016\/j.adro.2026.102022_bib0037","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I","article-title":"Regulation of the CDK inhibitor p27 and its deregulation in cancer","volume":"183","author":"Slingerland","year":"2000","journal-title":"J Cell Physiol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109426000291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109426000291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:27Z","timestamp":1778889627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109426000291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2452109426000291"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2026.102022","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association of p27 With Prostate Cancer Outcomes: A Secondary Analysis of NRG\/RTOG 8610 and 9202","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2026.102022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"102022"}}