{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:13:37Z","timestamp":1792800817209,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.adro.2026.102069","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:53:32Z","timestamp":1782248012000},"page":"102069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Encouraging Local Control With Pediatric Spatially Fractionated Radiation Therapy"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-6310","authenticated-orcid":false,"given":"Roman O.","family":"Kowalchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia K.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hok Wan Chan","family":"Tseung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Schoettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Allen-Rhoades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea M.","family":"Self","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Grams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N.","family":"Laack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2026.102069_bib0001","article-title":"Spatially fractionated stereotactic body radiation therapy (Lattice) for large tumors","volume":"6","author":"Duriseti","year":"2021","journal-title":"Adv Radiat Oncol."},{"key":"10.1016\/j.adro.2026.102069_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110260","article-title":"Assessment of minimum target dose as a predictor of local failure after spine SBRT","volume":"195","author":"Kowalchuk","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0003","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/jamaoncol.2021.7008","article-title":"Development and assessment of a predictive score for vertebral compression fracture after stereotactic body radiation therapy for spinal metastases","volume":"8","author":"Kowalchuk","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0004","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jama.2010.261","article-title":"Stereotactic body radiation therapy for inoperable early stage lung cancer","volume":"303","author":"Timmerman","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.adro.2026.102069_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/418270","article-title":"Stereotactic body radiotherapy for metastatic and recurrent ewing sarcoma and osteosarcoma","volume":"2014","author":"Brown","year":"2014","journal-title":"Sarcoma"},{"key":"10.1016\/j.adro.2026.102069_bib0006","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/cncr.33306","article-title":"A multi-institutional phase 2 trial of stereotactic body radiotherapy in the treatment of bone metastases in pediatric and young adult patients with sarcoma","volume":"127","author":"Elledge","year":"2021","journal-title":"Cancer"},{"issue":"suppl 2","key":"10.1016\/j.adro.2026.102069_bib0007","article-title":"Osteosarcoma","volume":"68","author":"Eaton","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.adro.2026.102069_bib0008","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.radonc.2021.11.023","article-title":"LITE SABR M1: A phase I trial of Lattice stereotactic body radiotherapy for large tumors","volume":"167","author":"Duriseti","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0009","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad2ee8","article-title":"Automated target placement for VMAT lattice radiation therapy: Enhancing efficiency and consistency","volume":"69","author":"Deufel","year":"2024","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.adro.2026.102069_bib0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ejmp.2018.05.019","article-title":"Design and clinical use of a rotational phantom for dosimetric verification of IMRT\/VMAT treatments","volume":"50","author":"Grams","year":"2018","journal-title":"Physica Medica"},{"key":"10.1016\/j.adro.2026.102069_bib0011","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/j.prro.2020.10.007","article-title":"VMAT grid therapy: A widely applicable planning approach","volume":"11","author":"Grams","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0012","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1016\/j.prro.2022.03.005","article-title":"A dosimetric comparison of lattice, brass, and proton grid therapy treatment plans","volume":"12","author":"Grams","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0013","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.1016\/j.prro.2024.12.002","article-title":"Highs and lows of spatially fractionated radiation therapy: Dosimetry and clinical outcomes","volume":"15","author":"Owen","year":"2025","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0014","article-title":"Spatially fractionated radiation therapy in sarcomas: A large single-institution experience","volume":"9","author":"Ahmed","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0015","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S1470-2045(19)30825-3","article-title":"Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): A multicentre, single-arm, phase 2 trial","volume":"21","author":"Italiano","year":"2020","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.adro.2026.102069_bib0016","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1038\/s41598-025-87395-9","article-title":"Spatially fractionated minibeam radiation delivered at clinically feasible dose rates induces transient vascular permeability","volume":"15","author":"Fazzari","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.adro.2026.102069_bib0017","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s43018-022-00450-6","article-title":"A phase I\/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC","volume":"3","author":"Darragh","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.adro.2026.102069_bib0018","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ijrobp.2020.09.041","article-title":"Reduction of lung metastases in a mouse osteosarcoma model treated with carbon ions and immune checkpoint inhibitors","volume":"109","author":"Helm","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102069_bib0019","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ijrobp.2021.03.047","article-title":"Personalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR) in preclinical models enhances single-agent immune checkpoint blockade","volume":"110","author":"Moore","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"22S","key":"10.1016\/j.adro.2026.102069_bib20","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/BRS.0b013e3181b8b6f5","article-title":"Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?","volume":"34","author":"Gerszten","year":"2009","journal-title":"Spine"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942600076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245210942600076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:34:56Z","timestamp":1786707296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245210942600076X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S245210942600076X"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2026.102069","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Encouraging Local Control With Pediatric Spatially Fractionated Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2026.102069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"102069"}}