{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:08:00Z","timestamp":1789124880485,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["advancesradonc.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Radiation Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.adro.2026.102135","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:26:50Z","timestamp":1789122410000},"page":"102135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation Therapy for Sialorrhea in Patients With Amyotrophic Lateral Sclerosis: A Case Series and Critical Review"],"prefix":"10.1016","volume":"11","author":[{"given":"Ella","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2204-1230","authenticated-orcid":false,"given":"Patrick","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Shamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huned S.","family":"Patwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly L.","family":"Johung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.adro.2026.102135_bib0001","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.adro.2026.102135_bib0002","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41576-023-00592-y","article-title":"Amyotrophic lateral sclerosis: Translating genetic discoveries into therapies","volume":"24","author":"Ak\u00e7imen","year":"2023","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.adro.2026.102135_bib0003","first-page":"647","article-title":"Pathophysiology, clinical heterogeneity, and therapeutic advances in amyotrophic lateral sclerosis: A comprehensive review of molecular mechanisms, diagnostic challenges, and multidisciplinary management strategies","volume":"15","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2025","journal-title":"Life (Basel)"},{"key":"10.1016\/j.adro.2026.102135_bib0004","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/21678421.2023.2165947","article-title":"Epidemiology and economic burden of amyotrophic lateral sclerosis in the United States: A literature review","volume":"24","author":"Berry","year":"2023","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.adro.2026.102135_bib0005","first-page":"19","article-title":"Sialorrhea in patients with ALS: Current treatment options","volume":"9","author":"Garuti","year":"2019","journal-title":"Degener Neurol Neuromuscul Dis"},{"key":"10.1016\/j.adro.2026.102135_bib0006","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ijrobp.2022.04.029","article-title":"The use of low-dose radiation therapy in osteoarthritis: A review","volume":"114","author":"Dove","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102135_bib0007","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s42466-022-00224-6","article-title":"ALSFRS-R-SE: An adapted, annotated, and self-explanatory version of the revised amyotrophic lateral sclerosis functional rating scale","volume":"4","author":"Maier","year":"2022","journal-title":"Neurol Res Pract"},{"key":"10.1016\/j.adro.2026.102135_bib0008","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0360-3016(98)00153-9","article-title":"The role of radiation therapy in the management of sialorrhea","volume":"41","author":"Borg","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102135_bib0009","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.canrad.2013.01.010","article-title":"Salivary glands radiotherapy to reduce sialorrhea in amyotrophic lateral sclerosis: Dose and energy","volume":"17","author":"Bourry","year":"2013","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.adro.2026.102135_bib0010","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1468-1331.2007.01983.x","article-title":"Radiotherapy reduces sialorrhea in amyotrophic lateral sclerosis","volume":"14","author":"Neppelberg","year":"2007","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.adro.2026.102135_bib0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jns.2011.06.016","article-title":"Unilateral parotid electron beam radiotherapy as palliative treatment for sialorrhea in amyotrophic lateral sclerosis","volume":"308","author":"Kasarskis","year":"2011","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.adro.2026.102135_bib0012","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/jpm.2010.0308","article-title":"Comparison of radiotherapy types in the treatment of sialorrhea in amyotrophic lateral sclerosis","volume":"14","author":"Guy","year":"2011","journal-title":"J Palliat Med"},{"key":"10.1016\/j.adro.2026.102135_bib0013","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ijrobp.2013.11.230","article-title":"Radiation therapy for hypersalivation: A prospective study in 50 amyotrophic lateral sclerosis patients","volume":"88","author":"Assouline","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102135_bib0014","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.58.8.1308","article-title":"Results of radiotherapy for drooling in amyotrophic lateral sclerosis","volume":"58","author":"Stalpers","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.adro.2026.102135_bib0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0022-510X(01)00631-1","article-title":"External radiation of the parotid glands significantly reduces drooling in patients with motor neurone disease with bulbar paresis","volume":"191","author":"Andersen","year":"2001","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.adro.2026.102135_bib0016","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2310\/7070.2001.19779","article-title":"Use of radiotherapy for control of sialorrhea in patients with amyotrophic lateral sclerosis","volume":"30","author":"Harriman","year":"2001","journal-title":"J Otolaryngol"},{"key":"10.1016\/j.adro.2026.102135_bib0017","first-page":"57","article-title":"Variation in worldwide incidence of amyotrophic lateral sclerosis: A meta-analysis","volume":"46","author":"Marin","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.adro.2026.102135_bib0018","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.15585\/mmwr.mm6746a1","article-title":"Prevalence of amyotrophic lateral sclerosis - United States, 2015","volume":"67","author":"Mehta","year":"2018","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.adro.2026.102135_bib0019","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00415-021-10928-5","article-title":"A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: Identifying exposures determining higher ALS risk","volume":"269","author":"Re","year":"2022","journal-title":"J Neurol"},{"key":"10.1016\/j.adro.2026.102135_bib0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: A conspiracy of genes, environment and time","volume":"9","author":"Al-Chalabi","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.adro.2026.102135_bib0021","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1212\/WNL.0000000000005996","article-title":"The multistep hypothesis of ALS revisited: The role of genetic mutations","volume":"91","author":"Chi\u00f2","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.adro.2026.102135_bib0022","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","article-title":"Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.adro.2026.102135_bib0023","article-title":"Treatment for sialorrhea (excessive saliva) in people with motor neuron disease\/amyotrophic lateral sclerosis","volume":"5","author":"James","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.adro.2026.102135_bib0024","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","article-title":"Amyotrophic lateral sclerosis","volume":"344","author":"Rowland","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.adro.2026.102135_bib0025","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp.2010.235952","article-title":"Phenotypic heterogeneity of amyotrophic lateral sclerosis: A population based study","volume":"82","author":"Chi\u00f2","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.adro.2026.102135_bib0026","article-title":"Treatment for sialorrhea (excessive saliva) in people with motor neuron disease\/amyotrophic lateral sclerosis","volume":"5","author":"Young","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.adro.2026.102135_bib0027","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4187\/respcare.02856","article-title":"A review of options for treating sialorrhea in amyotrophic lateral sclerosis","volume":"60","author":"Banfi","year":"2015","journal-title":"Respir Care"},{"key":"10.1016\/j.adro.2026.102135_bib0028","series-title":"StatPearls","first-page":"1","article-title":"Anatomy, head and neck, salivary glands","author":"Ghannam","year":"2025"},{"key":"10.1016\/j.adro.2026.102135_bib0029","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1212\/WNL.53.5.1059","article-title":"Nutritional status is a prognostic factor for survival in ALS patients","volume":"53","author":"Desport","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.adro.2026.102135_bib0030","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/WNL.0b013e3181bc01a4","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.adro.2026.102135_bib0031","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/jnnp.2008.149708","article-title":"Cause of death and clinical grading criteria in a cohort of amyotrophic lateral sclerosis cases undergoing autopsy from the Scottish Motor Neurone Disease Register","volume":"80","author":"Kurian","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.adro.2026.102135_bib0032","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4187\/respcare.07005","article-title":"The oral secretion scale and prognostic factors for survival in subjects with amyotrophic lateral sclerosis","volume":"65","author":"Cazzolli","year":"2020","journal-title":"Respir Care"},{"key":"10.1016\/j.adro.2026.102135_bib0033","article-title":"Symptomatic treatments for amyotrophic lateral sclerosis\/motor neuron disease","volume":"1","author":"Ng","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.adro.2026.102135_bib0034","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/21678421.2012.735238","article-title":"Validation of robust tools to measure sialorrhea in amyotrophic lateral sclerosis: A study in a large French cohort","volume":"14","author":"Abdelnour-Mallet","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.adro.2026.102135_bib0035","article-title":"European Academy of Neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European Reference Network for Neuromuscular Diseases (ERN EURO-NMD)","volume":"31","author":"Van Damme","year":"2024","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.adro.2026.102135_bib0036","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0885-3924(03)00323-3","article-title":"Quality of life and psychosocial issues in ventilated patients with amyotrophic lateral sclerosis and their caregivers","volume":"26","author":"Kaub-Wittemer","year":"2003","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.adro.2026.102135_bib0037","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1212\/01.wnl.0000233840.41688.df","article-title":"Caregiver time use in ALS","volume":"67","author":"Chi\u00f2","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.adro.2026.102135_bib0038","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-050185","article-title":"Caregiver burden and associated factors among primary caregivers of patients with ALS in home care: A cross-sectional survey study","volume":"11","author":"Tang","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.adro.2026.102135_bib0039","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tripleo.2005.08.018","article-title":"Drooling of saliva: A review of the etiology and management options","volume":"101","author":"Meningaud","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.adro.2026.102135_bib0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.oraloncology.2016.12.031","article-title":"Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis","volume":"66","author":"Mercadante","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.adro.2026.102135_bib0041","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.oraloncology.2007.02.006","article-title":"A structured review and theme analysis of papers published on 'quality of life' in head and neck cancer: 2000-2005","volume":"43","author":"Rogers","year":"2007","journal-title":"Oral Oncol"},{"key":"10.1016\/j.adro.2026.102135_bib0042","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.ijrobp.2010.05.048","article-title":"Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig","volume":"78","author":"Xu","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.adro.2026.102135_bib0043","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1038\/sj.mt.6300296","article-title":"Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands","volume":"15","author":"Cotrim","year":"2007","journal-title":"Mol Ther"},{"key":"10.1016\/j.adro.2026.102135_bib0044","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/jrr\/rru019","article-title":"Classification of radiation effects for dose limitation purposes: History, current situation and future prospects","volume":"55","author":"Hamada","year":"2014","journal-title":"J Radiat Res"},{"key":"10.1016\/j.adro.2026.102135_bib0045","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/mds.21752","article-title":"Radiotherapy to the salivary glands as treatment of sialorrhea in patients with parkinsonism","volume":"22","author":"Postma","year":"2007","journal-title":"Mov Disord"},{"key":"10.1016\/j.adro.2026.102135_bib0046","article-title":"Using intensity modulated radiation therapy for the treatment of sialorrhea in amyotrophic lateral sclerosis","volume":"8","author":"Ati","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.adro.2026.102135_bib0047","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.amjoto.2015.02.017","article-title":"IMRT for head and neck cancer: Cost implications","volume":"37","author":"Razfar","year":"2016","journal-title":"Am J Otolaryngol"}],"container-title":["Advances in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109426001429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452109426001429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:27:25Z","timestamp":1789122445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452109426001429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2452109426001429"],"URL":"https:\/\/doi.org\/10.1016\/j.adro.2026.102135","relation":{},"ISSN":["2452-1094"],"issn-type":[{"value":"2452-1094","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation Therapy for Sialorrhea in Patients With Amyotrophic Lateral Sclerosis: A Case Series and Critical Review","name":"articletitle","label":"Article Title"},{"value":"Advances in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.adro.2026.102135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology.","name":"copyright","label":"Copyright"}],"article-number":"102135"}}