{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:21:06Z","timestamp":1774376466456,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.advms.2016.04.003","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T10:32:55Z","timestamp":1462789975000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Myriocin treatment affects lipid metabolism in skeletal muscles of rats with streptozotocin-induced type 1 diabetes"],"prefix":"10.1016","volume":"62","author":[{"given":"Krzysztof","family":"Kurek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Garbowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika M.","family":"Ziembicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart\u0142omiej","family":"\u0141ukaszuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Rogowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Chabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"G\u00f3rski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"\u017bendzian-Piotrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.advms.2016.04.003_bib0465","series-title":"IDF Diabetes","author":"International Diabetes Federation","year":"2013"},{"key":"10.1016\/j.advms.2016.04.003_bib0240","author":"Organization WH"},{"key":"10.1016\/j.advms.2016.04.003_bib0470","series-title":"National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014","author":"Centers for Disease Control and Prevention","year":"2014"},{"key":"10.1016\/j.advms.2016.04.003_bib0250","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbalip.2009.09.014","article-title":"Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle","author":"Zhang","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.advms.2016.04.003_bib0255","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2337\/diabetes.51.1.7","article-title":"Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes","volume":"51","author":"McGarry","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.advms.2016.04.003_bib0260","doi-asserted-by":"publisher","first-page":"e85547","DOI":"10.1371\/journal.pone.0085547","article-title":"Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes","author":"Miklosz","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.advms.2016.04.003_bib0265","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1159\/000438584","article-title":"The role of PGC-1alpha in the development of insulin resistance in skeletal muscle \u2013 revisited","volume":"37","author":"Lukaszuk","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.advms.2016.04.003_bib0270","doi-asserted-by":"publisher","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.advms.2016.04.003_bib0275","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1096\/fj.03-1065fje","article-title":"Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT\/CD36","author":"Bonen","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.advms.2016.04.003_bib0280","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1159\/000373975","article-title":"Modest decrease in Pgc1alpha results in TAG accumulation but not in insulin resistance in L6 myotubes","author":"Lukaszuk","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.advms.2016.04.003_bib0285","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1301\/nr.2007.jun.S39-S46","article-title":"Lipid mediators of insulin resistance","volume":"65","author":"Holland","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1016\/j.advms.2016.04.003_bib0290","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1042\/bj3540359","article-title":"Ceramide dissociates 3\u2032-phosphoinositide production from pleckstrin homology domain translocation","volume":"354","author":"Stratford","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.advms.2016.04.003_bib0295","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1006\/mcne.1999.0813","article-title":"Inhibition of PKB\/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells","volume":"15","author":"Salinas","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.advms.2016.04.003_bib0300","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1006\/bbrc.2000.4248","article-title":"Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells","volume":"280","author":"Zinda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.advms.2016.04.003_bib0305","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.plipres.2005.11.002","article-title":"Ceramides in insulin resistance and lipotoxicity","volume":"45","author":"Summers","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0310","doi-asserted-by":"publisher","first-page":"30015","DOI":"10.1074\/jbc.M302548200","article-title":"Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis","volume":"278","author":"Kelpe","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.advms.2016.04.003_bib0315","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2337\/diabetes.52.3.726","article-title":"Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function","volume":"52","author":"Maedler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.advms.2016.04.003_bib0320","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0014-5793(95)00470-T","article-title":"Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta","volume":"367","author":"Sjoholm","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.advms.2016.04.003_bib0325","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.advms.2016.04.003_bib0475","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/908907","article-title":"Metabolism, physiological role, and clinical implications of sphingolipids in gastrointestinal tract","volume":"2013","author":"Kurek","year":"2013","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.advms.2016.04.003_bib0335","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1210\/er.2007-0025","article-title":"Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism","author":"Holland","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.advms.2016.04.003_bib0340","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S1388-1981(03)00059-3","article-title":"Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism","volume":"1632","author":"Hanada","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.advms.2016.04.003_bib0345","doi-asserted-by":"publisher","first-page":"208","DOI":"10.7164\/antibiotics.47.208","article-title":"Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite","volume":"47","author":"Fujita","year":"1994","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.advms.2016.04.003_bib0350","doi-asserted-by":"publisher","first-page":"10284","DOI":"10.1074\/jbc.M412348200","article-title":"Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice","volume":"280","author":"Hojjati","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.advms.2016.04.003_bib0355","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.phrs.2008.06.005","article-title":"Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice","volume":"58","author":"Park","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0360","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cmet.2007.01.002","article-title":"Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance","volume":"5","author":"Holland","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.advms.2016.04.003_bib0365","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.2337\/db09-1293","article-title":"Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption","volume":"59","author":"Ussher","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.advms.2016.04.003_bib0370","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/liv.12331","article-title":"Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease","volume":"34","author":"Kurek","year":"2014","journal-title":"Liver Int"},{"key":"10.1016\/j.advms.2016.04.003_bib0480","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/980815","article-title":"Inhibition of ceramide de novo synthesis with myriocin affects lipid metabolism in the liver of rats with streptozotocin-induced type 1 diabetes","volume":"2014","author":"Kurek","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.advms.2016.04.003_bib0380","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"10.1016\/j.advms.2016.04.003_bib0385","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1006\/abio.2002.5579","article-title":"Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase","author":"Min","year":"2002","journal-title":"Anal Biochem"},{"key":"10.1016\/j.advms.2016.04.003_bib0390","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S0076-6879(00)11077-8","article-title":"Sphingomyelinase assay using radiolabeled substrate","volume":"311","author":"Liu","year":"2000","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.advms.2016.04.003_bib0395","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/S0076-6879(00)11081-X","article-title":"Ceramidases","volume":"311","author":"Nikolova-Karakashian","year":"2000","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.advms.2016.04.003_bib0485","article-title":"Inhibition of ceramide de novo synthesis ameliorates diet induced skeletal muscles insulin resistance","volume":"2015","author":"Kurek","year":"2015","journal-title":"J Dia Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0405","doi-asserted-by":"publisher","first-page":"256707","DOI":"10.1155\/2012\/256707","article-title":"Animal models of diabetes mellitus for islet transplantation","volume":"2012","author":"Sakata","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0410","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1111\/j.1742-4658.2012.08575.x","article-title":"Ceramide profiles in the brain of rats with diabetes induced by streptozotocin","volume":"279","author":"Car","year":"2012","journal-title":"FEBS J"},{"key":"10.1016\/j.advms.2016.04.003_bib0415","doi-asserted-by":"publisher","first-page":"E211","DOI":"10.1152\/ajpendo.91014.2008","article-title":"Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome","volume":"297","author":"Yang","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.advms.2016.04.003_bib0420","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0029-1238322","article-title":"Effects of streptozotocin-induced diabetes and elevation of plasma FFA on ceramide metabolism in rat skeletal muscle","volume":"42","author":"Blachnio-Zabielska","year":"2010","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0425","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s00424-005-1509-0","article-title":"Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state","volume":"451","author":"van Loon","year":"2006","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.advms.2016.04.003_bib0430","doi-asserted-by":"publisher","first-page":"5159","DOI":"10.1210\/en.2003-0870","article-title":"Mini review: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome","volume":"144","author":"Unger","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.advms.2016.04.003_bib0435","doi-asserted-by":"publisher","first-page":"12583","DOI":"10.1074\/jbc.M611157200","article-title":"Key role for ceramides in mediating insulin resistance in human muscle cells","volume":"282","author":"Pickersgill","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.advms.2016.04.003_bib0440","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1172\/JCI30565","article-title":"Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance","volume":"117","author":"Liu","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.advms.2016.04.003_bib0445","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2013.01.041","article-title":"Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction","volume":"228","author":"Dekker","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.advms.2016.04.003_bib0450","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s11745-013-3769-3","article-title":"Fiber specific changes in sphingolipid metabolism in skeletal muscles of hyperthyroid rats","volume":"48","author":"Chabowski","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.advms.2016.04.003_bib0455","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1194\/jlr.M010595","article-title":"Circulating sphingolipid biomarkers in models of type 1 diabetes","volume":"52","author":"Fox","year":"2011","journal-title":"J Lipid Res"},{"key":"10.1016\/j.advms.2016.04.003_bib0460","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cmet.2014.09.015","article-title":"CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance","volume":"20","author":"Raichur","year":"2014","journal-title":"Cell Metab"}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S189611261630013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S189611261630013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T08:36:11Z","timestamp":1567845371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S189611261630013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S189611261630013X"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2016.04.003","relation":{},"ISSN":["1896-1126"],"issn-type":[{"value":"1896-1126","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myriocin treatment affects lipid metabolism in skeletal muscles of rats with streptozotocin-induced type 1 diabetes","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2016.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.","name":"copyright","label":"Copyright"}]}}