{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:01:05Z","timestamp":1774036865044,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for the Development of Biotechnology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.advms.2020.05.001","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T05:29:54Z","timestamp":1589952594000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of the tumor necrosis factor superfamily member 11 gene polymorphism with bone mineral density and bone fracture frequency in patients with postmenopausal osteoporosis"],"prefix":"10.1016","volume":"65","author":[{"given":"Anna","family":"Wawrzyniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-107X","authenticated-orcid":false,"given":"Marzena","family":"Skrzypczak-Zielinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Krela-Kazmierczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Marszalek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalina","family":"Marcinkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliwia","family":"Zakerska-Banaszak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"Slomski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.advms.2020.05.001_bib1","first-page":"358","article-title":"Familial resemblance for bone mineral mass is expressed before puberty","volume":"83","author":"Ferrari","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.advms.2020.05.001_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.beem.2008.08.007","article-title":"Human genetics of osteoporosis","volume":"22","author":"Ferrari","year":"2008","journal-title":"Best Pract Res Clin Endocrinol Metabol"},{"key":"10.1016\/j.advms.2020.05.001_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/bmb\/ldu042","article-title":"The genetics of osteoporosis","volume":"113","author":"Clark","year":"2015","journal-title":"Br Med Bull"},{"key":"10.1016\/j.advms.2020.05.001_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/2359-3997000000178","article-title":"Genetics of osteoporosis: searching for candidate genes for bone fragility","volume":"60","author":"Rocha-Braz","year":"2016","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.advms.2020.05.001_bib5","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nrrheum.2016.118","article-title":"The genetics of bone mass and susceptibility to bone diseases","volume":"22","author":"Karasik","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.advms.2020.05.001_bib6","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","article-title":"Multiple genetic loci for bone mineral density and fractures","volume":"358","author":"Styrkarsdottir","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.advms.2020.05.001_bib7","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0140-6736(08)60599-1","article-title":"Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study","volume":"371","author":"Richards","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.advms.2020.05.001_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001372","article-title":"Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk","volume":"7","author":"Duncan","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.advms.2020.05.001_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"10.1016\/j.advms.2020.05.001_bib10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar2165","article-title":"Biology of RANK RANKL and osteoprotegerin","volume":"9","author":"Boyce","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.advms.2020.05.001_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12178-009-9046-7","article-title":"RANK RANKL and osteoprotegerin in bone biology and disease","volume":"2","author":"Wright","year":"2009","journal-title":"Curr Rev Musculoskelet Med"},{"key":"10.1016\/j.advms.2020.05.001_bib12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"15","author":"Eghbali-Fatourechi","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.advms.2020.05.001_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/1759720X18805759","article-title":"New and emerging concepts in the use of denosumab for the treatment of osteoporosis","volume":"10","author":"Lewiecki","year":"2018","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.advms.2020.05.001_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.maturitas.2006.03.004","article-title":"Association of TNFSF11 gene promoter polymorphisms with bone mineral density in postmenopausal women","volume":"20","author":"Mencej","year":"2006","journal-title":"Maturitas"},{"key":"10.1016\/j.advms.2020.05.001_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1677\/JME-08-0003","article-title":"Tumour necrosis factor superfamily member 11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in postmenopausal women with osteoporosis","volume":"40","author":"Mencej","year":"2008","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.advms.2020.05.001_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/EJE-09-0617","article-title":"Allelic variations of RANKL\/OPG signaling system are related to bone mineral density and in vivo gene expression","volume":"162","author":"Tak\u00e1cs","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.advms.2020.05.001_bib17","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S8756-3282(00)00381-1","article-title":"Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis","volume":"27","author":"Kanis","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.advms.2020.05.001_bib18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s001980050281","article-title":"An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation","volume":"11","author":"Kanis","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.advms.2020.05.001_bib19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF01623782","article-title":"Guidelines for diagnosis and management of osteoporosis. The European foundation for osteoporosis and bone disease","volume":"7","author":"Kanis","year":"1997","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.advms.2020.05.001_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.advms.2020.05.001_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1365.035","article-title":"Bone remodeling","volume":"1092","author":"Hadjidakis","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.advms.2020.05.001_bib22","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.18632\/oncotarget.2160","article-title":"Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL","volume":"5","author":"Schieferdecker","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.advms.2020.05.001_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/13697137.2017.1315088","article-title":"-643C>T RANKL gene polymorphism is associated with osteoporosis in Tunisian postmenopausal women","volume":"20","author":"Sassi","year":"2017","journal-title":"Climacteric"},{"key":"10.1016\/j.advms.2020.05.001_bib24","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00223-009-9255-5","article-title":"Association analyses of RANKL\/RANK\/OPG gene polymorphisms with FN compression strength index variation in Caucasians","volume":"85","author":"Dong","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.advms.2020.05.001_bib25","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.clinbiochem.2013.03.011","article-title":"Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women","volume":"46","author":"Shang","year":"2013","journal-title":"Clin Biochem"},{"key":"10.1016\/j.advms.2020.05.001_bib26","first-page":"350","article-title":"VDR and TNFSF11 polymorphisms are associated with osteoporosis in Thai patients","volume":"9","author":"Techapatiphandee","year":"2018","journal-title":"Biomed Rep"},{"key":"10.1016\/j.advms.2020.05.001_bib27","first-page":"415","article-title":"-643C\/T polymorphism of RANKL gene and its association with osteoporosis in postmenopausal women","volume":"6","author":"Boro\u0144","year":"2014","journal-title":"Ann Acad Med Siles"},{"key":"10.1016\/j.advms.2020.05.001_bib28","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/jbmr.3419","article-title":"Multiple functional variants at 13q14 risk locus for osteoporosis regulate RANKL expression through long-range super-enhancer","volume":"33","author":"Zhu","year":"2018","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.advms.2020.05.001_bib29","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s00198-018-4573-y","article-title":"Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density","volume":"29","author":"Mo","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.advms.2020.05.001_bib30","doi-asserted-by":"crossref","first-page":"6407257","DOI":"10.1155\/2018\/6407257","article-title":"Meta-analysis of genome-wide association studies identifies novel functional CpG-SNPs associated with bone mineral density at lumbar spine","volume":"2018","author":"Qiu","year":"2018","journal-title":"Int J Genomics"},{"key":"10.1016\/j.advms.2020.05.001_bib31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bone.2018.06.001","article-title":"Genome-wide association study of extreme high bone mass: contribution of common genetic variation to extreme BMD phenotypes and potential novel BMD-associated genes","volume":"114","author":"Gregson","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.advms.2020.05.001_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bone.2018.05.012","article-title":"Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions","volume":"113","author":"Meng","year":"2018","journal-title":"Bone"}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S189611262030016X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S189611262030016X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:41:46Z","timestamp":1761824506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S189611262030016X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S189611262030016X"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2020.05.001","relation":{},"ISSN":["1896-1126"],"issn-type":[{"value":"1896-1126","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the tumor necrosis factor superfamily member 11 gene polymorphism with bone mineral density and bone fracture frequency in patients with postmenopausal osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2020.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of Medical University of Bialystok.","name":"copyright","label":"Copyright"}]}}