{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T07:30:48Z","timestamp":1787902248391,"version":"build-2784847793"},"reference-count":97,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Medical Sciences"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.advms.2020.08.002","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T03:03:32Z","timestamp":1598670212000},"page":"415-423","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease"],"prefix":"10.1016","volume":"65","author":[{"given":"Justyna","family":"Komorowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"W\u0105troba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Szukiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12126","article-title":"The aging population: demographics and the biology of aging","volume":"72","author":"Kanasi","year":"2016","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.advms.2020.08.002_bib2","author":"Tanna"},{"issue":"8","key":"10.1016\/j.advms.2020.08.002_bib3","first-page":"501","article-title":"Properties and molecular mechanisms of resveratrol","volume":"70","author":"Yang","year":"2015","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib4","first-page":"83","article-title":"Resveratrol, pterostilbene, and dementia","volume":"44","author":"Lange","year":"2017","journal-title":"BioFactors Special Issue: Resveratrol and Pterostilbene."},{"key":"10.1016\/j.advms.2020.08.002_bib5","first-page":"549850","article-title":"Isolation and characterization of some phytochemicals from Indian traditional plants","author":"Srivastava","year":"2012","journal-title":"Biotechnol Res Int"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib6","first-page":"1","article-title":"Trans-resveratrol and grape disease resistance. a dynamical study by high-resolution laser-based techniques","volume":"131","author":"Montero","year":"2013","journal-title":"Plant Physiol"},{"issue":"5A","key":"10.1016\/j.advms.2020.08.002_bib7","first-page":"2783","article-title":"Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies","volume":"24","author":"Aggarwal","year":"2004","journal-title":"Anticancer Res"},{"issue":"12","key":"10.1016\/j.advms.2020.08.002_bib8","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/j.1365-2621.2009.02077.x","article-title":"Polyphenols: food sources, properties and applications","volume":"44","author":"El Gharras","year":"2009","journal-title":"Int J Food Sci Technol"},{"issue":"11","key":"10.1016\/j.advms.2020.08.002_bib9","first-page":"3337","article-title":"Agric J. Plant foods and herbal sources of resveratrol","volume":"50","author":"Burns","year":"2002","journal-title":"ACS Publications"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.medici.2016.03.003","article-title":"Multiplicity of effects and health benefits of resveratrol","volume":"52","author":"Kur\u0161vietien\u0117","year":"2016","journal-title":"Medicina."},{"issue":"17","key":"10.1016\/j.advms.2020.08.002_bib11","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.2174\/1568026616666160204121431","article-title":"Resveratrol as a potential therapeutic candidate for the treatment and management of Alzheimer's disease","volume":"16","author":"Braidy","year":"2016","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mi.6.1.7","article-title":"Resveratrol in cardioprotection a therapeutic promise of alternative medicine","volume":"6","author":"Das","year":"2006","journal-title":"Mol Interv"},{"issue":"4","key":"10.1016\/j.advms.2020.08.002_bib13","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3945\/an.115.011627","article-title":"Resveratrol: how much wine do you have to drink to stay healthy?","volume":"7","author":"Weiskirchen","year":"2016","journal-title":"Advances Nutrition."},{"issue":"1\u20132","key":"10.1016\/j.advms.2020.08.002_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-014-2316-8","article-title":"Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells","volume":"402","author":"Morris","year":"2015","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1016\/j.advms.2020.08.002_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bcp.2004.05.008","article-title":"Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes","volume":"68","author":"Piver","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"22\u201324","key":"10.1016\/j.advms.2020.08.002_bib16","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1016\/j.phytochem.2007.09.014","article-title":"Nutraceuticals: facts and fiction","volume":"68","author":"Esp\u00edn","year":"2007","journal-title":"Phytochemistry"},{"issue":"12","key":"10.1016\/j.advms.2020.08.002_bib17","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.3390\/nu2121231","article-title":"Chemistry and biochemistry of dietary polyphenols","volume":"2","author":"Tsao","year":"2010","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.advms.2020.08.002_bib18","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bcp.2010.06.027","article-title":"Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite","volume":"80","author":"Holthoff","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"12","key":"10.1016\/j.advms.2020.08.002_bib19","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1211\/jpp.59.12.0010","article-title":"Antioxidant properties of phenols","volume":"59","author":"Foti","year":"2010","journal-title":"J Pharm Pharmacol"},{"issue":"24","key":"10.1016\/j.advms.2020.08.002_bib20","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1021\/jf048794e","article-title":"Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure","volume":"52","author":"Caruso","year":"2004","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbrc.2018.04.223","article-title":"Resveratrol induces dynamic changes to the microglia transcriptome, inhibiting inflammatory pathways and protecting against microglia-mediated photoreceptor apoptosis","volume":"501","author":"Wiedemann","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro- inflammation and induces adaptive immunity in Alzheimer's disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J Neuroinflammation"},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib23","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3390\/nu10060731","article-title":"Targeting histone deacetylases with natural and synthetic agents. An emerging anticancer strategy","volume":"10","author":"Singh","year":"2018","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.advms.2020.08.002_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/annotation\/5b9a8614-1009-40ca-b90b-db817fe445c9","article-title":"Resveratrol as a pan-HDAC inhibitor alters the acetylation status of jistone proteins in human-derived hepatoblastoma cells","volume":"8","author":"Venturelli","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.advms.2020.08.002_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41698-017-0038-6","article-title":"The therapeutic potential of resveratrol: a review of clinical trials","volume":"1","author":"Berman","year":"2017","journal-title":"NPJ Precis Oncol"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/21623945.2018.1469942","article-title":"The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans","volume":"7","author":"Most","year":"2018","journal-title":"J Adipocyte."},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib27","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.bbadis.2014.11.012","article-title":"Resveratrol and obesity: can resveratrol relieve metabolic disturbances?","volume":"1852","author":"Ligt","year":"2015","journal-title":"Biochim Biophys Acta (BBA) - Mol Basis Dis"},{"issue":"4","key":"10.1016\/j.advms.2020.08.002_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan","volume":"13","author":"Houtkooper","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.advms.2020.08.002_bib29","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1194\/jlr.M014647","article-title":"SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL","volume":"52","author":"Chakrabarti","year":"2011","journal-title":"J Lipid Res"},{"issue":"13","key":"10.1016\/j.advms.2020.08.002_bib30","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes Dev"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib31","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1096\/fj.11-195172","article-title":"Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding","volume":"26","author":"Purushotham","year":"2012","journal-title":"FASEB J."},{"issue":"44","key":"10.1016\/j.advms.2020.08.002_bib32","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"Ponugoti","year":"2010","journal-title":"J Biol Chem"},{"issue":"28","key":"10.1016\/j.advms.2020.08.002_bib33","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1073\/pnas.0802917105","article-title":"Sirt1 protects against high-fat diet-induced metabolic damage","volume":"105","author":"Pfluger","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"issue":"61","key":"10.1016\/j.advms.2020.08.002_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fct.2013.03.038","article-title":"Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties","volume":"2013","author":"Kasiotis","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"17","key":"10.1016\/j.advms.2020.08.002_bib36","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M500655200","article-title":"Substrate-specific activation of sirtuins by resveratrol","volume":"280","author":"Kaeberlein","year":"2005","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.advms.2020.08.002_bib37","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of human SIRT1 activation by resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J Biol Chem"},{"issue":"6124","key":"10.1016\/j.advms.2020.08.002_bib38","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1231097","article-title":"Evidence for a common mechanism of SIRT1 regulation by allosteric activators","volume":"339","author":"Hubbard","year":"2013","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib39","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2010.06.009","article-title":"Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis","volume":"12","author":"Kim","year":"2010","journal-title":"Cell Metabol"},{"issue":"7259","key":"10.1016\/j.advms.2020.08.002_bib40","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nature08360","article-title":"CBP\/p300-mediated acetylation of histone H3 on lysine 56","volume":"460","author":"Das","year":"2009","journal-title":"Nature"},{"issue":"7259","key":"10.1016\/j.advms.2020.08.002_bib41","first-page":"1164","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"460","author":"Herranz","year":"2009","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib42","first-page":"22","article-title":"Sirtuins, metabolism, and cancer","volume":"21","author":"Martinez-Pastor","year":"2012","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses b-amyloid production by activating the a-secretase gene ADAM10","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1523\/JNEUROSCI.3442-11.2012","article-title":"SIRT1 protects against a-synuclein aggregation by activating molecular chaperones","volume":"32","author":"Donmez","year":"2012","journal-title":"J Neurosci"},{"issue":"11","key":"10.1016\/j.advms.2020.08.002_bib45","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/jnr.22725","article-title":"Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling","volume":"89","author":"Guo","year":"2011","journal-title":"J Neurosci Res"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway","volume":"18","author":"Jeong","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets","volume":"18","author":"Jiang","year":"2011","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib48","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","article-title":"Acetylation of tau inhibits its degradation and contributes to tauopathy","volume":"67","author":"Min","year":"2010","journal-title":"Neuron"},{"issue":"29","key":"10.1016\/j.advms.2020.08.002_bib49","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1523\/JNEUROSCI.0027-10.2010","article-title":"SIRT1 is essential for normal cognitive function and synaptic plasticity","volume":"30","author":"Michan","year":"2010","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/156652410791065282","article-title":"Systemic DNA-damage response and metabolic syndrome as a premalignant state","volume":"10","author":"Erol","year":"2010","journal-title":"Curr Mol Med"},{"issue":"3\u20134","key":"10.1016\/j.advms.2020.08.002_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/1947601913483767","article-title":"The diversity of histone versus non-histone sirtuin substrates","volume":"4","author":"Martinez-Redondo","year":"2013","journal-title":"Genes Cancer."},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib52","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10522-013-9478-8","article-title":"SIRT6, a protein with many faces","volume":"14","author":"Gertler","year":"2013","journal-title":"Biogerontology"},{"issue":"11","key":"10.1016\/j.advms.2020.08.002_bib53","first-page":"7899","article-title":"Cardioprotective effect of resveratrol on atherogenic diet-fed rats","volume":"7","author":"Meng","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib54","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/09637486.2015.1077796","article-title":"Resveratrol and anti-atherogenic effects","volume":"66","author":"Riccioni","year":"2015","journal-title":"Int J Food Sci Nutr"},{"issue":"5","key":"10.1016\/j.advms.2020.08.002_bib55","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3892\/etm.2017.4180","article-title":"Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8\/A9 and VSMCs contractility in a rat model","volume":"13","author":"Wici\u0144ski","year":"2017","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib56","first-page":"1","article-title":"Antiplatelet activity of synthetic and natural resveratrol in red wine","volume":"17","author":"Bertelli","year":"1995","journal-title":"Drugs Exp Clin Res"},{"issue":"9","key":"10.1016\/j.advms.2020.08.002_bib57","doi-asserted-by":"crossref","first-page":"596","DOI":"10.7556\/jaoa.2018.133","article-title":"Resveratrol's potential in the adjunctive management of cardiovascular disease, obesity, diabetes, alzheimer disease, and cancer","volume":"118","author":"Kulashekar","year":"2018","journal-title":"J Am Osteopath Assoc"},{"key":"10.1016\/j.advms.2020.08.002_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jnutbio.2018.02.007","article-title":"Resveratrol improves glucose uptake in insulin-resistant adipocytes via Sirt1","volume":"55","author":"Chen","year":"2018","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.advms.2020.08.002_bib59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biopha.2018.03.050","article-title":"Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model","volume":"102","author":"Rehman","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"10.1016\/j.advms.2020.08.002_bib60","first-page":"602","article-title":"Effects of exercise and resveratrol on retinol binding protein 4, blood glucose and insulin sensitivity in aged obese rats","volume":"46","author":"Cui","year":"2017","journal-title":"Wei Sheng Yan Jiu"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib61","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/13813455.2018.1441872","article-title":"Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease","volume":"125","author":"Hajighasem","year":"2019","journal-title":"Arch Physiol Biochem"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib62","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.dld.2014.11.015","article-title":"Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial","volume":"47","author":"Chen","year":"2015","journal-title":"Dig Liver Di"},{"issue":"4","key":"10.1016\/j.advms.2020.08.002_bib63","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jalz.2016.03.001","article-title":"Alzheimer's disease facts and figures","volume":"12","author":"Gaugler","year":"2016","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.advms.2020.08.002_bib64","doi-asserted-by":"crossref","first-page":"15056","DOI":"10.1038\/nrdp.2015.56","article-title":"Alzheimer's disease","volume":"1","author":"Masters","year":"2015","journal-title":"Nat Rev Dis Primers."},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40142-014-0034-x","article-title":"Late-onset Alzheimer's disease genes and the potentially implicated pathways","volume":"2","author":"Rosenthal","year":"2014","journal-title":"Curr Genet Med Rep"},{"key":"10.1016\/j.advms.2020.08.002_bib66","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2147\/CIA.S51571","article-title":"The genetics of Alzheimer's disease","volume":"9","author":"Bagyinszky","year":"2014","journal-title":"Clin Interv Aging"},{"issue":"Suppl 2","key":"10.1016\/j.advms.2020.08.002_bib67","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J Neurochem"},{"key":"10.1016\/j.advms.2020.08.002_bib68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-94-007-5416-4_14","article-title":"Alzheimer's disease","volume":"65","author":"De-Paula","year":"2012","journal-title":"Subcell Biochem"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib69","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/bmc-2016-0029","article-title":"Alzheimer's disease as an inflammatory disease","volume":"8","author":"Bol\u00f3s","year":"2017","journal-title":"Biomol Concepts"},{"key":"10.1016\/j.advms.2020.08.002_bib70","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5604\/17322693.1029530","article-title":"Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. from molecular mechanisms to therapeutic strategies","volume":"67","author":"Karpi\u0144ska","year":"2013","journal-title":"Postepy Hig Med Dosw"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib71","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-141506","article-title":"Anti-inflammatory drugs and risk of Alzheimer's disease: an updated systematic review and meta-analysis","volume":"44","author":"Wang","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.advms.2020.08.002_bib72","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5604\/17322693.1029530","article-title":"Oxidative stress and natural antioxidant mechanisms: the role in neurodegeneration. From molecular mechanisms to therapeutic strategies","volume":"67","author":"Karpi\u0144ska","year":"2013","journal-title":"Postepy Hig Med Dosw"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib73","first-page":"151","article-title":"The effects of resveratrol on oxidant\/antioxidant systems and their cofactors in rats","volume":"22","author":"Kavas","year":"2013","journal-title":"Adv Clin Exp Med"},{"issue":"5","key":"10.1016\/j.advms.2020.08.002_bib74","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/mnfr.200400098","article-title":"Resveratrol: preventing properties against vascular alterations and ageing","volume":"49","author":"Delmas","year":"2005","journal-title":"Mol Nutr Food Res"},{"issue":"1\u20132","key":"10.1016\/j.advms.2020.08.002_bib75","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mrrev.2007.08.004","article-title":"Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?","volume":"658","author":"Saiko","year":"2008","journal-title":"Mutation Res"},{"issue":"16","key":"10.1016\/j.advms.2020.08.002_bib76","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double- blind, placebo- controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.advms.2020.08.002_bib77","first-page":"9","article-title":"Resveratrol and amyloid-beta: mechanistic insights","volume":"14","author":"Jia","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib78","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1567205012666150204130009","article-title":"Resveratrol protects \u03b2 amyloid-induced oxidative damage and memory associated proteins in H19-7 hippocampal neuronal cells","volume":"12","author":"Rege","year":"2015","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib79","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/biof.1063","article-title":"Curcumin and neurodegenerative diseases","volume":"39","author":"Monroy","year":"2013","journal-title":"Biofactors"},{"issue":"10","key":"10.1016\/j.advms.2020.08.002_bib80","first-page":"9","article-title":"Resveratrol and amyloid-beta: mechanistic insights","volume":"14","author":"Jia","year":"2017","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib81","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00204-016-1784-x","article-title":"Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells","volume":"91","author":"Deus","year":"2017","journal-title":"Arch Toxicol"},{"issue":"11","key":"10.1016\/j.advms.2020.08.002_bib82","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4172\/2155-9880.1000216","article-title":"The sirtuin system: the holy grail of resveratrol?","volume":"3","author":"Mohar","year":"2012","journal-title":"J Clin Exp Cardiolog"},{"key":"10.1016\/j.advms.2020.08.002_bib83","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1101\/sqb.2007.72.024","article-title":"Sirtuins in aging and disease","volume":"72","author":"Guarente","year":"2007","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1016\/j.advms.2020.08.002_bib84","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1038\/npjamd.2016.17","article-title":"It takes two to tango: NAD+ and sirtuins in aging\/longevity control","volume":"2","author":"Imai","year":"2016","journal-title":"NPJ Aging Mech Dis"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib85","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.advms.2015.09.003","article-title":"The role of sirtuins in aging and age-related diseases","volume":"61","author":"Watroba","year":"2016","journal-title":"Adv Med Sci"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib86","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.advms.2020.08.002_bib87","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s11064-016-2110-y","article-title":"Sirtuins and their roles in brain aging and neurodegenerative disorders","volume":"42","author":"J\u0119\u015bko","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.advms.2020.08.002_bib88","first-page":"5","article-title":"Sirtuins in neurodegenerative diseases: an update on potential mechanisms","volume":"53","author":"Min","year":"2013","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"10.1016\/j.advms.2020.08.002_bib89","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s12035-018-1157-y","article-title":"Resveratrol induces brain resilience against alzheimer neurodegeneration through proteostasis enhancement","volume":"56","author":"Corpas","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.advms.2020.08.002_bib90","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.neuroscience.2018.03.047","article-title":"Effect of resveratrol on the inflammation in cultured astrocytes and microglia induced by a\u03b21-42","volume":"379","author":"Zhao","year":"2018","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib91","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/molecules23010196","article-title":"Dietary total prenylflavonoids from the fruits of Psoralea corylifolia L. Prevents age-related cognitive deficits and down-regulates Alzheimer's markers in SAMP8 mice","volume":"23","author":"Chen","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.advms.2020.08.002_bib92","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2741\/4650","article-title":"Biophysical interaction of resveratrol with sirtuin pathway: significance in Alzheimer's disease","volume":"23","author":"Mohan","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.advms.2020.08.002_bib93","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbr.2017.10.032","article-title":"Resveratrol promotes hUC-MSCs engraftment and neural repair in a mouse model of Alzheimer's disease","volume":"339","author":"Wang","year":"2018","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.advms.2020.08.002_bib94","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2017.10.021","article-title":"Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease","volume":"282","author":"Wang","year":"2018","journal-title":"Toxicol Lett."},{"issue":"6","key":"10.1016\/j.advms.2020.08.002_bib95","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/ijms20061381","article-title":"Progress to improve oral bioavailability and beneficial effects of resveratrol","volume":"20","author":"Chimento","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.advms.2020.08.002_bib96","series-title":"Resveratrol - adding life to years, not adding years to life","article-title":"Novel drug delivery systems of resveratrol to bioavailability and therapeutic effects","volume":"vol. 6","author":"Devi","year":"2019"},{"issue":"1","key":"10.1016\/j.advms.2020.08.002_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.08.014","article-title":"Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders","volume":"232","author":"Pasinetti","year":"2011","journal-title":"Exp. NeuroFl."}],"container-title":["Advances in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112620300341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1896112620300341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:41:27Z","timestamp":1761824487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1896112620300341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1896112620300341"],"URL":"https:\/\/doi.org\/10.1016\/j.advms.2020.08.002","relation":{},"ISSN":["1896-1126"],"issn-type":[{"value":"1896-1126","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review of beneficial effects of resveratrol in neurodegenerative diseases such as Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Advances in Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.advms.2020.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}